Composition with anti-inflammatory, blood oxygen content increasing, cancer cell growth inhibiting and tumor treatment side effects alleviation and its application

Abstract

The invention discloses a composition with the functions of anti-inflammatory, increasing blood oxygen content, inhibiting cancer cell growth and alleviating the side effects of tumor treatment, specifically comprising: tangerine peel, ginseng, cinnamon bark, ergothioneine, houttuynia cordata, kelp, dandelion, turmeric, epigallocatechin gallate, naringin, chitosan oligosaccharide, zinc gluconate and taurine. The composition provided by the invention integrates the treatment concept of "softening and dispersing nodules" of traditional medicine and "evidence-based treatment" of modern medicine, and the raw materials are scientifically compatible and synergistic, and jointly play the functions of anti-inflammatory, improving body immunity and improving the blood oxygen content level of the lesion site, etc., and has the advantages of better inhibiting the growth of cancer cells, inhibiting the expression of hypoxia-inducible factor HIF, alleviating the side effects of tumor treatment, etc., and is safe and efficient, and has broad application prospects.

Description

Technical Field

[0001] The present invention relates to the field of medicine and food homology and compound preparations, and in particular to a composition having the functions of anti-inflammation, increasing blood oxygen content, inhibiting cancer cell growth and alleviating side effects of tumor treatment and its application. Background Art

[0002] Gastric cancer refers to a malignant tumor originating from the epithelial cells of the gastric mucosa. As a common malignant tumor, gastric cancer seriously affects the life, health and quality of life of patients. Although modern medicine has made significant progress in surgery, radiotherapy, chemotherapy, targeted therapy and immunotherapy, these treatments are often accompanied by serious side effects and adverse reactions, and may also lead to the development of drug resistance. Therefore, how to reduce toxicity and increase efficacy and improve efficacy is an important issue in the current research on comprehensive treatment of malignant tumors.

[0003] As a more gentle and effective treatment option, Chinese medicine has a long history in the treatment of gastric cancer. Traditional medicine believes that gastric cancer belongs to the categories of "dysphagia", "regurgitation", "lumps", and "epigastric pain". The stomach is the "sea of ​​water and grain", and the spleen is the source of Qi and blood. If the stomach fails to harmonize and descend, and the spleen fails to ascend, then the water and grain cannot be transformed into essence, and the internal aggregation will produce phlegm and dampness, which will hinder the Qi movement, cause Qi stagnation and blood stasis, and the phlegm and blood stasis will form a mass. In other words, the occurrence of gastric cancer is closely related to the deficiency of vital energy and the retention of phlegm and blood stasis. Therefore, a Chinese medicine composition that can play the role of "balancing the middle state, softening and dispersing nodules" is expected to become an important means of preventing and treating gastric cancer.

[0004] In addition, studies have shown that pro-inflammatory factors can induce the degeneration and abnormal differentiation of gastric epithelial cells, thereby stimulating the proliferation of cancer cells, and are a "barometer" of tumor progression. At the same time, increased levels of pro-inflammatory factors are often considered an important sign of inflammation. Therefore, reducing the level of pro-inflammatory factors to exert anti-inflammatory effects is also an important means of treating gastric cancer.

[0005] With the continuous progress of modern medicine, the prevention and treatment of tumors has gradually shifted to the intervention and regulation of the tumor microenvironment. Hypoxia is the most important feature of the tumor microenvironment. During the progression of cancer, tumor cells proliferate rapidly, the tumor vascular system is abnormal, and the vascular network cannot be quickly established, leading to the emergence of a hypoxic state in the microenvironment. In a hypoxic microenvironment, tumor cells can regulate the activation of hypoxia inducible factor (HIF), and the overexpression of HIF is closely related to the activation of downstream target genes, especially growth factors and invasion and metastasis-related genes. Therefore, increasing the blood oxygen concentration at the tumor site and improving the poor blood perfusion environment inside the tumor are of great significance for inhibiting the activation of the transcription factor HIF and solving a series of problems caused by the hypoxic microenvironment.

[0006] Traditional Chinese medicine has some shortcomings, such as slow efficacy and unsatisfactory effects. In order to improve the shortcomings of traditional Chinese medicine in treatment, it is necessary to combine modern medical research and development ideas to develop more effective compound compositions. Summary of the invention

[0007] In view of this, in order to overcome the defects of the prior art, the present invention has developed a composition that has anti-inflammatory, increases blood oxygen content, inhibits cancer cell growth and alleviates the side effects of tumor treatment. The composition can regulate the pH and oxygen microenvironment in the patient's body, has specificity and multiple targets, exerts a synergistic effect of 1+1>2, and can reduce the side effects produced during the treatment process.

[0008] The composition is composed of the following raw materials in parts by weight: 10-35 parts of ginseng, 10-30 parts of cinnamon bark, 5-20 parts of tangerine peel, 10-30 parts of houttuynia cordata, 5-15 parts of kelp, 10-30 parts of dandelion, 5-20 parts of turmeric, 0.01-0.03 parts of ergothioneine, 0.05-0.2 parts of epigallocatechin gallate, 0.1-0.8 parts of naringin, 0.1-0.5 parts of chitosan oligosaccharide, 0.01-0.03 parts of zinc gluconate and 0.5-1.5 parts of taurine.

[0009] Furthermore, the composition is composed of the following raw materials in parts by weight: 20-35 parts of ginseng, 10-25 parts of cinnamon, 10-20 parts of tangerine peel, 20-30 parts of houttuynia cordata, 10-15 parts of kelp, 20-30 parts of dandelion, 10-20 parts of turmeric, 0.01-0.03 parts of ergothioneine, 0.08-0.2 parts of epigallocatechin gallate, 0.3-0.8 parts of naringin, 0.2-0.5 parts of chitosan oligosaccharide, 0.01-0.03 parts of zinc gluconate, and 0.8-1.5 parts of taurine.

[0010] Furthermore, the composition is composed of the following raw materials in parts by weight: 20-30 parts of ginseng, 10-20 parts of cinnamon, 10-15 parts of tangerine peel, 20-25 parts of houttuynia cordata, 10-15 parts of kelp, 20-25 parts of dandelion, 10-20 parts of turmeric, 0.02-0.03 parts of ergothioneine, 0.1-0.2 parts of epigallocatechin gallate, 0.5-0.8 parts of naringin, 0.3-0.5 parts of chitosan oligosaccharide, 0.02-0.03 parts of zinc gluconate, and 1-1.5 parts of taurine.

[0011] Further preferably, in order to better improve the effect of the composition, the composition may also be added with active ingredients such as vitamin B6, vitamin B12, and folic acid.

[0012] Another object of the present invention is to provide a composite preparation of a composition having the effects of anti-inflammation, increasing blood oxygen content, inhibiting cancer cell growth and alleviating the side effects of tumor treatment, characterized in that the raw materials include the composition.

[0013] Furthermore, the compound preparation also includes conventionally acceptable excipients.

[0014] Further preferably, the compound preparation also includes food or pharmaceutically acceptable excipients.

[0015] Furthermore, the auxiliary materials include one or more of the following: diluents, wetting agents, lubricants, binders, disintegrants, inclusion agents, flavoring agents, sustained-release agents, dispersants, plasticizers and opacifiers.

[0016] Furthermore, the composite preparation is in the form of granules, pills, powders, drop pills, tablets, capsules or oral liquid preparations.

[0017] The present invention also provides a preparation method of the composition, which is characterized by comprising the steps of crushing ginseng, cinnamon bark, dried orange peel, houttuynia cordata, kelp, dandelion and turmeric respectively, extracting and combining them through a conventional extraction process to prepare an extract fine powder mixture, and then adding ergothioneine, epigallocatechin gallate, naringin, chitosan oligosaccharide, zinc gluconate and taurine to mix and prepare the composition.

[0018] Furthermore, the extraction process comprises adding 5 to 15 times the weight of the raw material of water for heating extraction, repeating the extraction 2 to 3 times, removing the filter residue, combining the filtrate, concentrating and drying the powder.

[0019] The present invention also provides the use of the composition or the composite preparation in preparing a preparation having the effects of anti-inflammation, increasing blood oxygen content, inhibiting cancer cell growth and alleviating the side effects of tumor treatment.

[0020] The composite composition of the present invention has been subjected to toxic and side effect experiments, and the results show that it has no significant effect on the experimental rats and is highly safe. In addition, previous experiments on gastric cancer cells have shown that the anti-cancer effects of using a combination of Chinese medicinal raw materials or a combination of monomeric active ingredients alone at the same dose, and a combination of adjusting the weight ratio of raw materials are not ideal, while the composite of the present application shows a good synergistic effect in the anti-cancer cell test.

[0021] The functions of each raw material component are briefly described as follows:

[0022] Ginseng is sweet and warm in nature. It can greatly replenish vital energy, restore pulse and strengthen deficiency, nourish spleen and lung, promote body fluid and nourish blood, calm nerves and improve intelligence. It can be used to strengthen the body, improve immunity, reduce the toxic side effects of radiotherapy and chemotherapy, and improve the quality of life of patients.

[0023] Cinnamon is spicy and warm in nature. It cures all diseases, nourishes the spirit, and improves complexion. It has the effects of warming the middle and dispersing cold, helping yang and consolidating deficiency, and can promote blood circulation and improve blood oxygen supply to various parts of the body.

[0024] Turmeric tastes pungent and bitter, and is warm in nature. It has the effects of promoting blood circulation, promoting qi, and relieving pain. It can be used to treat chest and flank pain, chest obstruction, heartache and other symptoms caused by qi stagnation and blood stasis. Modern studies have shown that its main active ingredient, curcumin, has multiple pharmacological effects in the fight against gastric cancer, including inhibiting cell proliferation, inducing cell apoptosis, regulating signal pathways, and inhibiting tumor angiogenesis.

[0025] Huajuhong tastes pungent, bitter and warm. It has the effects of regulating qi and resolving phlegm, drying dampness and strengthening the spleen. It can be used to treat symptoms such as epigastric pain and fullness caused by spleen and stomach qi stagnation and internal obstruction of phlegm and dampness.

[0026] Houttuynia cordata tastes pungent, slightly cold and slightly bitter. It has the effects of clearing away heat and detoxifying, eliminating carbuncles and draining pus, and promoting diuresis and relieving stranguria, and can alleviate the symptoms of heat and toxicity caused by tumors.

[0027] Dandelion is cold in nature and sweet in taste. It enters the liver and stomach meridians. It has the effects of clearing away heat and detoxifying, reducing swelling and dispersing nodules, and promoting diuresis and relieving stranguria.

[0028] Kelp tastes salty and is cold in nature. It enters the liver, stomach, and kidney meridians. It has the effects of eliminating phlegm, softening and dispersing nodules, promoting diuresis and reducing swelling, and preventing and fighting cancer.

[0029] Ergothioneine is a multifunctional cell physiological protective agent, with the functions of scavenging free radicals, maintaining the normal growth of cells, cellular immunity, radiation resistance and anti-aging, especially playing an important role in anti-oxidation and energy regulation. The ergothioneine used in the present application can be obtained by extracting from natural organisms such as Pleurotus eryngii and Agaricus bisporus, or by chemical synthesis and fermentation.

[0030] Epigallocatechin gallate (EGCG) is an important active ingredient in green tea, ginkgo and emblica. EGCG has the functions of preventing and treating various diseases such as cancer and enhancing immunity.

[0031] Chitosan oligosaccharides are made from chitin by chemical or enzymatic methods. As a natural alkaline polysaccharide, they have high water solubility, antioxidant, anti-inflammatory, anti-tumor, and immunomodulatory activities.

[0032] Naringin is a flavonoid compound with anti-inflammatory, antioxidant and anti-cancer properties. Naringin can fight gastric cancer through multiple mechanisms, including blocking the cell cycle, inducing programmed cell death, anti-tumor and inhibiting angiogenesis.

[0033] Zinc gluconate may play an auxiliary role by supporting the immune system and promoting the normal function of cells. Zinc can activate different types of immune cells and stimulate immune cells to secrete a variety of cytokines, thereby protecting the immune function.

[0034] Taurine is a sulfur-containing non-protein amino acid that plays a variety of important biological functions in the human body, including promoting the development and function of the nervous system, maintaining the health of the cardiovascular system, enhancing the body's immunity, and improving anti-cancer efficacy.

[0035] Vitamin B6 can improve human immunity and participate in various biochemical reactions such as amino acid, glucose, lipid and DNA metabolism as a coenzyme, affecting DNA synthesis, phosphorylation and repair. Vitamin B12 plays a key role in maintaining the normal function of the brain and nervous system and blood flow formation. Folic acid plays an important role as a carrier in nucleotide synthesis and methylation reaction of one-carbon groups. Modern studies have shown that folic acid supplementation can effectively reverse the progression of chronic atrophic gastritis and reduce the incidence of gastric cancer.

[0036] The invention has the following beneficial effects: gastric cancer belongs to the syndrome of deficiency in the root and excess in the superficial. The deficiency in the root is spleen and kidney deficiency, which is manifested as congenital deficiency of kidney essence and acquired deficiency of spleen and stomach qi. Therefore, cinnamon is used to warm kidney essence and ginseng is used to strengthen spleen and replenish qi to strengthen the body and cure the root. Excess in the superficial is cancer cell invasion. Cancer toxins invade the stomach to block the movement of qi, blood and body fluids, which will inevitably cause the three evils of poison, blood stasis and phlegm to gather in the stomach. Houttuynia cordata and dandelion are used to clear away heat and detoxify, kelp softens and disperses nodules, and tangerine peel and turmeric are used to dry dampness and resolve phlegm, promote blood circulation and remove blood stasis. The prescription is used together to achieve the effects of tonifying spleen and kidney, softening and dispersing nodules, clearing heat and resolving phlegm, so as to restore the positive energy, eliminate cancer toxins, clear heat and resolve phlegm turbidity. With the development of medicine, cancer treatment has entered a diversified comprehensive treatment stage. In order to better improve the therapeutic effect of the composition, the present invention combines modern medical concepts to add ergothioneine, epigallocatechin gallate, naringin, chitosan oligosaccharides, zinc gluconate, and taurine to improve the anti-inflammatory, anti-tumor, and immune regulation effects of the complex, combines natural active ingredients with traditional Chinese medicine, and multiple targets and multiple links jointly play a more comprehensive and complex role in the fields of anti-inflammation, increasing blood oxygen content, inhibiting cancer cell growth, and alleviating side effects of tumor treatment. BRIEF DESCRIPTION OF THE DRAWINGS

[0037] Figure 1 Comparison of tumor inhibition effects in rats of each group.

[0038] Figure 2 Comparison of serum inflammatory factor levels in rats of each group.

[0039] Figure 3 Comparison of immune indicators of rats in each group. Figure 3 A in the figure is the expression level of IgG, Figure 3 B in the figure is the expression level of IgM. Figure 3 C in the figure is the expression level of IgA.

[0040] Figure 4 Comparison of HIF-1ɑ and VEGF expression in gastric tumor tissues of each group. Figure 4A in the table is the expression level of HIF-1ɑ, Figure 4 B in the figure is the expression level of VEGF.

[0041] Note: Compared with the blank control group, * P<0.05, △ P<0.01; compared with the model control group, # P<0.05. DETAILED DESCRIPTION

[0042] The present invention is described clearly and completely below in conjunction with specific embodiments, but the present invention is not limited thereto. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in the field without creative work are within the scope of protection of the present invention.

[0043] Embodiment 1: A composition having anti-inflammatory, blood oxygen content increasing, cancer cell growth inhibiting and tumor treatment side effect alleviating properties, characterized in that the composition is composed of the following raw materials in parts by weight: 35 parts of ginseng, 30 parts of cinnamon, 20 parts of tangerine peel, 30 parts of houttuynia cordata, 15 parts of kelp, 30 parts of dandelion, 20 parts of turmeric, 0.03 parts of ergothioneine, 0.2 parts of epigallocatechin gallate, 0.8 parts of naringin, 0.5 parts of chitosan oligosaccharide, 0.03 parts of zinc gluconate and 1.5 parts of taurine.

[0044] The preparation method of the composition comprises the following steps: respectively taking ginseng, cinnamon bark, dried tangerine peel, houttuynia cordata, kelp, dandelion and turmeric according to the amount, crushing them, respectively adding cold water equivalent to 8 times the amount of the medicinal materials to soak for 1 hour, boiling for 30 minutes, filtering to obtain the filtrate, adding 5 times the amount of water to continue decocting for 25 minutes, filtering, combining the filtrate, concentrating the decoction by using a rotary evaporator, drying and crushing to obtain an extract powder, mixing the extract powder, and then adding corresponding amounts of ergothioneine, epigallocatechin gallate, naringin, chitosan oligosaccharide, zinc gluconate and taurine to mix and prepare the composition.

[0045] Embodiment 2: A composition having anti-inflammatory, blood oxygen content increasing, cancer cell growth inhibiting and tumor treatment side effect alleviating properties, characterized in that the composition is composed of the following raw materials in parts by weight: 25 parts of ginseng, 15 parts of cinnamon, 12 parts of tangerine peel, 20 parts of houttuynia cordata, 10 parts of kelp, 25 parts of dandelion, 15 parts of turmeric, 0.03 parts of ergothioneine, 0.1 parts of epigallocatechin gallate, 0.6 parts of naringin, 0.5 parts of chitosan oligosaccharide, 0.03 parts of zinc gluconate and 1.2 parts of taurine.

[0046] The preparation method of the composition comprises the following steps: taking ginseng, cinnamon bark, dried tangerine peel, houttuynia cordata, kelp, dandelion and turmeric respectively according to the amount, crushing them, adding cold water equivalent to 10 times the amount of the medicinal materials respectively, soaking them for 0.5 hours, boiling them for 45 minutes, filtering and collecting the filtrate, adding 5 times the amount of water and continuing to decoct for 20 minutes, filtering, combining the filtrate, concentrating the decoction by using a rotary evaporator, drying and crushing the decoction to obtain an extract powder, mixing the extract powder, and then adding corresponding amounts of ergothioneine, epigallocatechin gallate, naringin, chitosan oligosaccharide, zinc gluconate and taurine to mix and prepare the composition.

[0047] Embodiment 3: A composition having anti-inflammatory, blood oxygen content increasing, cancer cell growth inhibiting and tumor treatment side effect alleviating properties, characterized in that the composition is composed of the following raw materials in parts by weight: 30 parts of ginseng, 20 parts of cinnamon, 15 parts of tangerine peel, 25 parts of houttuynia cordata, 15 parts of kelp, 25 parts of dandelion, 20 parts of turmeric, 0.03 parts of ergothioneine, 0.2 parts of epigallocatechin gallate, 0.8 parts of naringin, 0.5 parts of chitosan oligosaccharide, 0.03 parts of zinc gluconate and 1.5 parts of taurine.

[0048] The preparation steps are the same as in Example 1.

[0049] Embodiment 4: A composition having anti-inflammatory, blood oxygen content increasing, cancer cell growth inhibiting and tumor treatment side effect alleviating properties, characterized in that the composition is composed of the following raw materials in parts by weight: 20 parts of ginseng, 10 parts of cinnamon, 10 parts of tangerine peel, 20 parts of houttuynia, 10 parts of kelp, 20 parts of dandelion, 10 parts of turmeric, 0.02 parts of ergothioneine, 0.1 parts of epigallocatechin gallate, 0.5 parts of naringin, 0.3 parts of chitosan oligosaccharide, 0.02 parts of zinc gluconate and 1 part of taurine.

[0050] The preparation steps are the same as in Example 1.

[0051] Embodiment 5: A composition having anti-inflammatory, blood oxygen content increasing, cancer cell growth inhibiting and tumor treatment side effect alleviating properties, characterized in that the composition is composed of the following raw materials in parts by weight: 10 parts of ginseng, 10 parts of cinnamon, 5 parts of tangerine peel, 10 parts of houttuynia cordata, 5 parts of kelp, 10 parts of dandelion, 5 parts of turmeric, 0.01 parts of ergothioneine, 0.05 parts of epigallocatechin gallate, 0.1 parts of naringin, 0.1 parts of chitosan oligosaccharide, 0.01 parts of zinc gluconate and 0.5 parts of taurine.

[0052] The preparation steps are the same as in Example 1.

[0053] Test example: Experimental test of the effect of the compound composition of the present application

[0054] The animal experiment of the present invention uses SPF grade male rats weighing 180-220g, free access to food and water, and the experiment is conducted after adaptive feeding for 1 week. Other reagent raw materials are conventional products that can be purchased commercially. The human BGC823 gastric cancer cell line was selected and subcultured to prepare a living cell suspension. 0.8mL of human gastric cancer cell suspension was subcutaneously inoculated near the inner groin of the rat, and the number of cells inoculated per rat was 5×10 6 , and a gastric cancer rat model was made. The gastric cancer rats with successful modeling were randomly divided into a blank group, a model group, an embodiment 1 group, an embodiment 2 group, and an embodiment 3 group, with 10 rats in each group. The embodiment group was gavaged at a dose of 80 mg / kg every day, and the blank group and the model group were gavaged with an equal dose of normal saline. After gavage for 21 days in each group of rats, they were anesthetized and killed to obtain serum and gastric tumor tissue for the following experimental detection.

[0055] (1) Tumor weight and growth inhibition rate: The abdominal cavity of the rats was opened under a sterile environment, and the pylorus and cardia of the rats were ligated with surgical thread. The whole stomach was cut out between the two ligatures and rinsed with PBS solution to absorb excess water. The stomach was placed on filter paper to expose the tumor site and the tumor weight was recorded by weighing.

[0056] Table 1 Comparison of tumor inhibition effects in rats of each group (MEAN±SD, n=10)

[0057]

[0058] The results are shown in Table 1 and Figure 1 As shown, the results show that compared with the model control group, under the intervention of the compound composition of the present application, the tumor weight of the rats in Examples 1-3 was significantly reduced, and the difference in rat tumor weight compared with the model control group was statistically significant (P<0.05). It can be seen that under the combined effect of the raw material components of the formula, the composition of the present application can effectively inhibit the growth of tumor cells, thereby achieving the purpose of treating gastric cancer.

[0059] (2) Enzyme-linked immunosorbent assay for serum inflammatory factors: Rat serum was collected and the serum inflammatory factors IL-6 and IL-10 were determined using enzyme-linked immunosorbent assay.

[0060] Table 2 Comparison of serum inflammatory factor levels in rats of each group (MEAN±SD, n=10)

[0061]

[0062] IL-10 and IL-6 are key cytokines of inflammatory response, and changes in their levels can reflect the inflammatory state in the body. In the development of gastric cancer, inflammatory response is a key factor. The results are shown in Table 2 and Figure 2The results showed that the inflammatory factors in the model group gastric cancer rats were significantly higher than those in the blank group, indicating that the model was successfully established. Compared with the model group, the IL-6 and IL-10 levels in the compound composition example group were significantly lower than those in the model group, indicating that the composition can reduce the inflammatory response of gastric cancer rats and has a good anti-inflammatory effect.

[0063] (3) Immunoglobulin IgG, IgM and IgA levels were detected by immunoturbidimetry:

[0064] Table 3 Comparison of immune indexes of rats in each group (MEAN±SD, n=10)

[0065]

[0066] The results are shown in Table 3 and Figure 3 It can be seen that the immune indexes of the rats in the tumor-bearing model group were significantly lower than those in the blank group. Compared with the model group, the immune indexes of the embodiment group were significantly higher than those of the model group, indicating that the immune system is responding to the treatment and producing more antibodies, thereby regulating the body's immune function of gastric cancer rats. The improvement of immune indexes also proves the effectiveness of the compound composition in improving immune function, thereby reducing the side effects of treatment and improving the quality of life.

[0067] (4) Immunoblotting was used to detect the expression levels of VEGF and HIF-1α proteins in rat gastric tumor tissues.

[0068] Table 4 Comparison of HIF-1ɑ and VEGF expression in gastric tumor tissues of each group (MEAN±SD, n=10)

[0069]

[0070] Overexpression of hypoxia-inducible factor-1α (HIF-1α) is an important factor affecting tumor cell proliferation. VEGF can induce mitosis of vascular endothelial cells, directly stimulate angiogenesis and induce increased vascular permeability. The results are shown in Table 4 and Figure 4 As shown, compared with the model group, the example group can significantly downregulate the expression of HIF-1α and VEGF, which may be related to the fact that the active ingredients contained in the composition can increase the oxygen saturation of the body, that is, by increasing the oxygen concentration to improve the hypoxic microenvironment inside the tumor and thus change the abnormal angiogenesis, it plays a role in inhibiting the formation of tumor blood vessels. The above results show that taking the composition can increase the blood oxygen concentration of gastric cancer rats, thereby improving the tumor microenvironment and better enhancing the treatment effect.

[0071] Although the embodiments of the present invention are disclosed for illustrative purposes, those skilled in the art will appreciate that various substitutions, changes, deletions, additions and modifications are possible without departing from the spirit and scope of the present invention and the appended claims. Therefore, the scope of the present invention is not limited to the contents disclosed in the embodiments.

Claims

1. A composition for inhibiting the growth of gastric cancer cells and treating gastric cancer, characterized in that: The composition is composed of the following raw materials in parts by weight: 10-35 parts of ginseng, 10-30 parts of cinnamon bark, 5-20 parts of tangerine peel, 10-30 parts of houttuynia cordata, 5-15 parts of kelp, 10-30 parts of dandelion, 5-20 parts of turmeric, 0.01-0.03 parts of ergothioneine, 0.05-0.2 parts of epigallocatechin gallate, 0.1-0.8 parts of naringin, 0.1-0.5 parts of chitosan oligosaccharide, 0.01-0.03 parts of zinc gluconate and 0.5-1.5 parts of taurine.

2. The composition according to claim 1, characterized in that The composition is composed of the following raw materials in parts by weight: 20-35 parts of ginseng, 10-25 parts of cinnamon bark, 10-20 parts of tangerine peel, 20-30 parts of houttuynia cordata, 10-15 parts of kelp, 20-30 parts of dandelion, 10-20 parts of turmeric, 0.01-0.03 parts of ergothioneine, 0.08-0.2 parts of epigallocatechin gallate, 0.3-0.8 parts of naringin, 0.2-0.5 parts of chitosan oligosaccharide, 0.01-0.03 parts of zinc gluconate and 0.8-1.5 parts of taurine.

3. The composition according to claim 1 or 2, characterized in that The composition is composed of the following raw materials in parts by weight: 20-30 parts of ginseng, 10-20 parts of cinnamon bark, 10-15 parts of tangerine peel, 20-25 parts of houttuynia cordata, 10-15 parts of kelp, 20-25 parts of dandelion, 10-20 parts of turmeric, 0.02-0.03 parts of ergothioneine, 0.1-0.2 parts of epigallocatechin gallate, 0.5-0.8 parts of naringin, 0.3-0.5 parts of chitosan oligosaccharide, 0.02-0.03 parts of zinc gluconate and 1-1.5 parts of taurine.

4. A composite preparation for inhibiting the growth of gastric cancer cells and treating gastric cancer, characterized in that: The raw material comprises the composition according to any one of claims 1 to 3.

5. The composite formulation according to claim 4, characterized in that The compound formulation also includes conventionally acceptable excipients.

6. The composite formulation according to claim 5, characterized in that The auxiliary materials include one or more of the following: diluents, wetting agents, lubricants, binders, disintegrants, inclusion agents, flavoring agents, sustained-release agents, dispersants, plasticizers and opacifiers.

7. The composite formulation according to claim 5 or 6, characterized in that: The compound preparation is in the form of granules, pills, powders, tablets, capsules or oral liquid preparations.

8. A method for preparing the composition according to any one of claims 1 to 3, characterized in that: The invention comprises the steps of crushing ginseng, cinnamon bark, dried orange peel, houttuynia cordata, kelp, dandelion and turmeric respectively, extracting and combining them through conventional extraction process to prepare a mixture of extract fine powder, and then adding ergothioneine, epigallocatechin gallate, naringin, chitosan oligosaccharide, zinc gluconate and taurine to mix the mixture.

9. The preparation method according to claim 8, characterized in that: The extraction process comprises adding 5 to 15 times the weight of the raw material of water for heating extraction, repeating the extraction 2 to 3 times, removing the filter residue, combining the filtrate, concentrating and drying, and crushing.

10. Use of the composition according to any one of claims 1 to 3 or the composite preparation according to any one of claims 4 to 7 in the preparation of a preparation for inhibiting the growth of gastric cancer cells or treating gastric cancer.

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