Quick-acting anti-alcoholism composition and preparation method thereof

Abstract

The invention provides a quick-acting anti-alcoholism composition and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine compositions. The quick-acting anti-alcoholism composition disclosed by the invention is prepared from the following components in parts by weight: 35-45 parts of a silibinin extract, 5-15 parts of a curcumin extract, 5-15 parts of a radix puerariae extract, 1-5 parts of piperine and 1-5 parts of corn oligopeptide. The biocompatibility and the absorption speed are increased by combining and proportioning the effective substances and preparing the nano-liposome, so that the aim of quickly dispelling the effects of alcohol is fulfilled.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a quick-acting alcohol-relieving composition and a preparation method thereof. Background Art

[0002] Alcohol is a common food in people's daily life, but excessive drinking is harmful to human health. The hazards of excessive drinking mainly include damage to the nerves, damage to the digestive system, and damage to the liver, etc., which poses a great threat to physical health.

[0003] In society, there is a situation where a large amount of alcohol is consumed in a short period of time, and the sequelae of drunkenness that last for many days seriously affect life and work. With the enhancement of health awareness, more and more people begin to pay attention to health care after drinking, which also brings huge commercial value to the hangover beverage market. With the improvement of people's living standards and the enhancement of health awareness, the hangover beverage market shows a rapid growth trend, the competition pattern of the hangover market is constantly optimized, and consumers' demand for hangover beverages is also changing. Not only do they require hangover beverages to effectively relieve the symptoms of drunkenness, but they also hope that they can bring certain health effects to the body. The hangover beverage market has broad prospects. At present, products for hangover usually have a slow effect, need to be taken for a long time, and are mainly aimed at patients who drink alcohol for a long time.

[0004] Therefore, there is an urgent need for a fast-acting hangover sobering product to help heavy drinkers in a short period of time to rapidly metabolize ethanol. Summary of the invention

[0005] In view of this, the object of the present invention is to provide a fast-acting hangover-relieving composition, which is quickly absorbed and effective, and can significantly reduce the time of drunkenness.

[0006] In order to achieve the above object, the present invention provides the following technical solutions:

[0007] The present invention provides a quick-acting hangover-relieving composition, which is prepared from the following raw materials in parts by weight:

[0008] 35-45 parts of silybin extract, 5-15 parts of curcumin extract, 5-15 parts of kudzu root extract, 1-5 parts of piperine, and 1-5 parts of corn oligopeptide.

[0009] Silybin extract is a compound extracted from the milk thistle plant. It is believed to protect liver cell membranes and improve liver function. Silybin can effectively decompose alcohol, speed up alcohol metabolism out of the body, relieve alcohol damage to the liver, reduce gastrointestinal discomfort symptoms such as nausea and vomiting caused by drunkenness, help sober up and prevent hangovers. Curcumin extract and kudzu root extract can help speed up the decomposition of alcohol, thereby reducing the burden on the body after drinking and relieving various discomforts after drunkenness. Corn oligopeptides are small molecule peptides that are easily absorbed by the human body and contain a variety of amino acids related to alcohol metabolism. Corn oligopeptides can stimulate the alcohol decomposition enzymes in the liver to achieve the effect of decomposing alcohol and help protect the stomach and liver.

[0010] Preferably, the raw material further comprises 0.01-0.05 parts of trace elements; the trace elements are one or more of zinc ions, iron ions, magnesium ions, selenium ions, copper ions, and manganese ions.

[0011] Preferably, the raw material also includes 0.01-0.05 parts of vitamins; the vitamins are one or more of vitamin C, vitamin A, vitamin D, vitamin E, vitamin B6, vitamin B12, thiamine, and riboflavin.

[0012] The present invention also provides a method for preparing the above-mentioned quick-acting hangover-relieving composition, comprising the following steps:

[0013] S1. Weigh the raw materials according to the weight parts;

[0014] S2. The silybin extract, curcumin extract, kudzu root extract, piperine, and surfactant were dissolved in deionized water and then ultrasonically dispersed to obtain a mixed solution A;

[0015] S3. dissolving trimyristin in ethanol to obtain a mixed solution B;

[0016] S4. Injecting the mixed solution A and the mixed solution B as the water phase and the oil phase into the microchannel to merge and obtain nanoliposomes;

[0017] S5. The nanoliposomes and corn oligopeptides are mixed evenly and then vacuum-freeze-dried to obtain a fast-acting hangover-relief composition. The present invention can form a liposome inclusion compound by encapsulating the effective substance inside the liposome. The inclusion compound has good biocompatibility and targeting, and can improve the bioavailability and absorption rate of silybin; at the same time, nanoparticles are prepared through microchannels to improve their solubility and large gastrointestinal contact area to provide bioavailability, thereby achieving rapid absorption by the human body and improving the hangover-relief rate.

[0018] Preferably, the surfactant in S2 is one or more of Tween 80, Span 80, Tween 60, Span 60, and Tween 20.

[0019] Preferably, the power of ultrasonic dispersion in S2 is 200-300w, and the time is 5-15min.

[0020] Preferably, the concentration of the mixed solution B in S3 is 10-50 mg / mL.

[0021] Preferably, the water phase flow rate in S4 is 5-10 mL / h, and the oil phase flow rate is 10-20 mL / h.

[0022] Preferably, the composition can be prepared into a drink, tablets, or granules.

[0023] Contains at least the following beneficial technical effects:

[0024] The alcohol sobering composition prepared by the invention has reasonable raw material composition and proportion, has obvious alcohol sobering function, and can shorten the drunkenness time by more than 60% as proved by experiments. DETAILED DESCRIPTION

[0025] The technical solution of the present invention is further described below.

[0026] Unless otherwise defined, technical or scientific terms used in the present invention shall have the common meanings understood by one having ordinary skills in the field to which the present invention belongs.

[0027] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above and that the present invention can be implemented in other specific forms without departing from the gist or essential features of the present invention. Therefore, the embodiments should be considered exemplary and non-restrictive in all respects, and the scope of the present invention is defined by the appended claims rather than the above description, and it is intended that all changes falling within the meaning and scope of the equivalent elements of the claims be included in the present invention.

[0028] In addition, it should be understood that although this specification is described according to the implementation modes, not every implementation mode includes only one independent technical solution. This description of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment can also be appropriately combined to form other implementation modes that can be understood by those skilled in the art. These other implementation modes are also covered within the protection scope of the present invention.

[0029] It should also be understood that the specific embodiments described above are only used to explain the present invention, and the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field, within the technical scope disclosed by the present invention, can make equivalent replacements or changes based on the technical solutions and inventive concepts of the present invention, which should be covered by the protection scope of the present invention / invention.

[0030] The raw materials used in the following examples are all commercially available.

[0031] Example 1

[0032] This embodiment provides a method for preparing a quick-acting hangover-relieving composition, and the steps are as follows:

[0033] S1. Weigh 40 parts of silybin extract, 10 parts of curcumin extract, 10 parts of kudzu root extract, 3 parts of piperine, 3 parts of corn oligopeptide, 0.02 parts of zinc ion, and 0.02 parts of vitamin C by weight;

[0034] S2. The silybin extract, curcumin extract, kudzu root extract, piperine and Tween 60 were dissolved in deionized water and then dispersed by ultrasonic to obtain a mixed solution A; wherein the deionized water was twice the total mass of the silybin extract, curcumin extract, kudzu root extract and piperine; the amount of Tween 60 was 0.5wt%; the power of ultrasonic dispersion was 250w, and the time was 10min;

[0035] S3. dissolving trimyristin in ethanol to obtain a 20 mg / mL mixed solution B;

[0036] S4. Injecting mixed solution A and mixed solution B into the microchannel as the water phase and the oil phase respectively to merge to obtain nanoliposomes; wherein the water phase flow rate is 6 mL / h, and the oil phase flow rate is 12 mL / h;

[0037] S5. The nanoliposomes are mixed evenly with corn oligopeptides, zinc ions and vitamin C, and then vacuum freeze-dried to obtain a fast-acting alcohol-relief composition.

[0038] Example 2

[0039] This embodiment provides a method for preparing a quick-acting hangover-relieving composition, and the steps are as follows:

[0040] S1. Weigh 35 parts of silybin extract, 5 parts of curcumin extract, 5 parts of kudzu root extract, 1 part of piperine, 1 part of corn oligopeptide, 0.01 parts of zinc ion, 0.01 parts of magnesium ion, 0.01 parts of selenium ion, and 0.02 parts of vitamin C by weight;

[0041] S2. The silybin extract, curcumin extract, kudzu root extract, piperine and Tween 60 were dissolved in deionized water and then dispersed by ultrasonic to obtain a mixed solution A; wherein the deionized water was 1 times the total mass of the silybin extract, curcumin extract, kudzu root extract and piperine; the amount of Tween 60 was 0.5wt%; the power of ultrasonic dispersion was 200w and the time was 5min;

[0042] S3. dissolving trimyristin in ethanol to obtain a 30 mg / mL mixed solution B;

[0043] S4. Injecting mixed solution A and mixed solution B into the microchannel as the water phase and the oil phase respectively to merge to obtain nanoliposomes; wherein the water phase flow rate is 5 mL / h, and the oil phase flow rate is 15 mL / h;

[0044] S5. Evenly mix the nanoliposomes with corn oligopeptides, zinc ions, magnesium ions, selenium ions and vitamin C, and then perform vacuum freeze-drying to obtain a fast-acting alcohol-relief composition.

[0045] Example 3

[0046] This embodiment provides a method for preparing a quick-acting hangover-relieving composition, and the steps are as follows:

[0047] S1. Weigh 45 parts of silybin extract, 15 parts of curcumin extract, 15 parts of kudzu root extract, 5 parts of piperine, 5 parts of corn oligopeptide, 0.02 parts of zinc ion, 0.01 parts of vitamin C, 0.01 parts of vitamin D, 0.01 parts of vitamin E, and 0.01 parts of vitamin B6 by weight;

[0048] S2. Silybin extract, curcumin extract, kudzu root extract, piperine and Tween 60 were dissolved in deionized water and then dispersed by ultrasonic to obtain a mixed solution A; wherein the deionized water was 3 times the total mass of silybin extract, curcumin extract, kudzu root extract and piperine; the amount of Tween 60 was 0.5wt%; the power of ultrasonic dispersion was 300w, and the time was 15min;

[0049] S3. dissolving trimyristin in ethanol to obtain 50 mg / mL mixed solution B;

[0050] S4. Injecting mixed solution A and mixed solution B into the microchannel as the water phase and the oil phase respectively to merge to obtain nanoliposomes; wherein the water phase flow rate is 10 mL / h, and the oil phase flow rate is 15 mL / h;

[0051] S5. The nanoliposomes are mixed evenly with corn oligopeptides, zinc ions, vitamin C, vitamin D, vitamin E and vitamin B6, and then vacuum freeze-dried to obtain a fast-acting alcohol-relief composition.

[0052] Comparative Example 1

[0053] Weigh 40 parts of silybin extract, 10 parts of curcumin extract, 10 parts of kudzu root extract, 3 parts of piperine, 3 parts of corn oligopeptide, 0.02 parts of zinc ion, and 0.02 parts of vitamin C by weight;

[0054] The above raw materials are mixed evenly to obtain a hangover-relieving composition.

[0055] Experimental Example 1

[0056] The quick-acting hangover-relief compositions prepared in Examples 1-3 and Comparative Examples 1-3 were used on drunken mice, and the hangover-relief time of the mice was counted.

[0057] 50 female mice weighing 20-30 g were randomly divided into a control group, Example 1-3 groups and Comparative Example 1 group with 10 mice in each group. The mice were fasted for 10 hours before the experiment. According to the weight of the mice, each group was gavaged with 53% ethanol (30 ml / kg); 30 minutes later, the mice in each group were given the drug at the same time;

[0058] The blank group was given distilled water, the Example 1-3 groups were given the compositions prepared in Examples 1-3 respectively; the Comparative Example 1 was given the composition prepared in Comparative Example 1; the dosage was calculated based on the body weight of the mice, 3 g / kg.

[0059] The activities of mice in each group after drinking were observed. Unsteady crawling, closed eyes and motionless with limbs facing upward were considered as indicators of drunkenness (loss of righting reflex), and free movement and good spirits were considered as indicators of not being drunk. The duration of drunkenness was calculated. The results are shown in Table 1.

[0060] Table 1

[0061] Group Average drunkenness time (min) Control group 143.8 Example 1 32.6 Example 2 38.2 Example 3 44.5 Comparative Example 1 72.4

[0062] As shown in Table 1, the compositions obtained in Examples 1-3 of the present invention can significantly shorten the time of drunkenness, shorten the time of drunkenness by more than 70%, and have the function of rapid sobering up. Although the effective substances in Comparative Example 1 are the same, they have not been coated with liposomes, have poor environmental tolerance, and have a slow absorption rate, resulting in a slow sobering up rate.

[0063] Experimental Example 2

[0064] The composition prepared in Example 1 of the present invention was distributed to people who might drink a lot of alcohol, and feedback on the rapid sobering up was received after waiting for 3 months. The feedback results are shown in Table 2.

[0065] Table 2

[0066] category Number of people Slightly effective 2 Clearly effective 23 invalid 1 No feedback 5

[0067] The above description is only the preferred embodiment of the present application and is not intended to limit the present application. For those skilled in the art, the present application may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A quick-acting hangover-relieving composition, characterized in that: Prepared from the following raw materials in parts by weight: 35-45 parts of silybin extract, 5-15 parts of curcumin extract, 5-15 parts of kudzu root extract, 1-5 parts of piperine, and 1-5 parts of corn oligopeptide.

2. The quick-acting hangover-relieving composition according to claim 1, characterized in that: The raw materials also include 0.01-0.05 parts of trace elements; the trace elements are one or more of zinc ions, iron ions, magnesium ions, selenium ions, copper ions, and manganese ions.

3. The quick-acting hangover-relieving composition according to claim 2, characterized in that: The raw materials also include 0.01-0.05 parts of vitamins; the vitamins are one or more of vitamin C, vitamin A, vitamin D, vitamin E, vitamin B6, vitamin B12, thiamine, and riboflavin.

4. The method for preparing the quick-acting hangover-relieving composition according to claim 3, characterized in that: The following steps are involved: S1. Weigh the raw materials according to the weight parts; S2. The silybin extract, curcumin extract, kudzu root extract, piperine, and surfactant were dissolved in deionized water and then ultrasonically dispersed to obtain a mixed solution A; S3. dissolving trimyristin in ethanol to obtain a mixed solution B; S4. Injecting the mixed solution A and the mixed solution B as the water phase and the oil phase into the microchannel to merge and obtain nanoliposomes; S5. The nanoliposomes and corn oligopeptides are mixed evenly and then vacuum-freeze-dried to obtain a fast-acting alcohol-relief composition.

5. The preparation method according to claim 4, characterized in that: The surfactant in S2 is one or more of Tween 80, Span 80, Tween 60, Span 60, and Tween 20.

6. The preparation method according to claim 4, characterized in that: The power of ultrasonic dispersion in S2 is 200-300w, and the time is 5-15min.

7. The preparation method according to claim 4, characterized in that: The concentration of the mixed solution B in S3 is 10-50 mg / mL.

8. The preparation method according to claim 4, characterized in that: The water phase flow rate in S4 is 5-10 mL / h, and the oil phase flow rate is 10-20 mL / h.

9. The quick-acting hangover-relieving composition according to claim 1, characterized in that: The composition can be prepared into a drink, tablets or granules.