Lily and polygonatum odoratum beverage and preparation method thereof

Abstract

The invention relates to a lily and polygonatum odoratum beverage and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine health drinks, the active ingredients are prepared from 12 g of lily, 12 g of polygonatum odoratum, 10 g of raspberry, 10 g of polygonatum sibiricum, 10 g of sharpleaf galangal fruit, 9 g of dahurian angelica root, 6 g of dried orange peel, 6 g of Lily and polygonatum odoratum in the formula can jointly tonify qi, nourish yin and moisten the lung, and can effectively relieve discomfort such as weakness and dry mouth; the raspberry, the rhizoma polygonati and the fructus alpiniae oxyphyllae can jointly tonify the kidney, warm the spleen and moisten the lung, and have a good treatment effect on yellow urine of patients with diabetes mellitus and nephropathy; angelica dahurica, pericarpium citri reticulatae, sophora flower bud and radix puerariae can tonify spleen and reduce phlegm, regulate blood sugar and blood fat, and relieve liver-kidney yin deficiency syndrome and other conditions of early diabetic patients. The lily and polygonatum odoratum beverage has the effects of simultaneously tonifying the lung, spleen and kidney without stagnation in the whole formula, and regulating cold and heat when the medicine is warm and cool. Through comprehensive conditioning of the beverage, clinical symptoms can be relieved, liver-kidney yin deficiency syndromes and other symptoms of early diabetic patients can be relieved, and the beverage has the effect of reducing blood sugar and blood fat.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine health-care beverages, and in particular relates to a lily and polygonatum odoratum beverage and a preparation method thereof. Background Art

[0002] Diabetes is one of the most common chronic diseases. With the improvement of quality of life, activities have decreased, obesity has increased, and the prevalence of diabetes has also increased. According to the statistics of the International Dairy Federation in 2019, there are currently 463 million people suffering from diabetes worldwide, of which 116 million are in China. Studies have shown that the overall standardized prevalence of diabetes in adults in my country is 12.8%, and the prevalence of prediabetes is as high as 35.7%. Therefore, the prevention and treatment of diabetes has become one of the major research topics in the world.

[0003] According to Chinese medicine, diabetes belongs to the category of "Xiao Ke" in Chinese medicine. Its pathogenesis is due to improper diet, emotional disorders, congenital deficiency, spleen and stomach weakness, and spleen and stomach dysfunction, which leads to qi and yin deficiency, turbid yin failure to descend, and dampness and turbidity coagulation. Qi and yin deficiency syndrome accounts for more than 40% of all syndromes and is the basic pathogenesis of type 2 diabetes. The main clinical manifestations are polydipsia, polyphagia, polyuria, and weight loss. If the disease is not treated in time, it will cause disorders in sugar, lipid and protein metabolism, and complications such as liver and kidney damage.

[0004] At present, conventional hypoglycemic drugs are not very effective in controlling blood sugar in patients, and have many adverse reactions. Traditional medicine has significant advantages in treating diabetes mellitus. Therefore, under the guidance of the basic theories of traditional Chinese medicine, research on effective, low-toxic and convenient prescriptions for the treatment of diabetes has important clinical application value. Summary of the invention

[0005] The technical problem to be solved by the present invention is to provide a lily and polygonatum odoratum beverage and a preparation method thereof, which is prepared according to the principle of monarch, minister, assistant and envoy formulation, has the effects of invigorating qi and promoting body fluid, nourishing the kidney and replenishing essence, can effectively alleviate the symptoms of diabetic patients, such as improving blurred vision, reducing urine foam, lowering blood sugar and blood lipids, etc., and has good therapeutic efficacy on diabetes mellitus or type 2 diabetes.

[0006] In order to achieve the above object, the technical solution adopted by the present invention is:

[0007] A lily and polygonatum odoratum beverage, wherein the effective ingredients are prepared from the following Chinese medicinal raw materials by weight:

[0008] Lily 10-15g; Polygonatum odoratum 10-15g; Raspberry 8-12g;

[0009] Polygonatum 8-12g; Alpinia oxyphylla 8-12g; Angelica dahurica 8-10g;

[0010] Tangerine peel 5-7g; Sophora japonica seeds 5-7g; Pueraria root 8-10g.

[0011] In the formula of Lily and Polygonatum, lily is sweet and cold, nourishes yin and moistens the lungs, and calms the mind; Polygonatum is sweet, slightly cold, and flat, which has the effects of invigorating qi and strengthening the spleen, promoting fluid and moistening the lungs. The main ingredients of this recipe are lily and Polygonatum, which can nourish qi, nourish yin and moisten the lungs, and can effectively relieve discomfort such as fatigue and dry mouth.

[0012] In the formula of Lily and Polygonatum, raspberry is sweet, sour and warm, and has the effects of nourishing the kidney, consolidating essence, reducing urine, nourishing the liver and improving eyesight; Polygonatum is sweet and flat, and has the effects of nourishing qi and yin, strengthening the spleen, moistening the lungs, and nourishing the kidneys, and nourishing the lungs, spleen and kidneys; Alpinia oxyphylla is pungent and warm, and has the effects of warming the kidney, consolidating essence, reducing urine, warming the spleen, stopping diarrhea and controlling saliva. This formula uses raspberry, Polygonatum and Alpinia oxyphylla to nourish the kidney, warm the spleen and moisten the lungs, and has a therapeutic effect on yellow urine with foam in patients with diabetic nephropathy.

[0013] In the formula of Lily and Polygonatum odoratum beverage, the adjuvants are: Angelica dahurica, Tangerine peel, Sophora japonica seeds and Pueraria root. Angelica dahurica is pungent and warm, and has the effect of dispersing external evils and clearing filth and turbidity; Tangerine peel is pungent and warm, and has the effect of strengthening the spleen and resolving phlegm, and the spleen is healthy and can be transported and transformed, so that the medicines can be nourished without stagnation; Sophora japonica seeds are cool in nature, and have the effect of restraining the pungent and warm nature of the above-mentioned medicines, and can also be used for health care and regulating blood sugar and blood lipids; Pueraria root can clear the body and quench thirst, and can help the main medicine produce body fluids. In addition, because the tonic medicines in the formula are transformed into fine substances through the transportation and transformation of the spleen, the fine substances can be raised through the lifting and lifting qi of Pueraria root, which can avoid the situation of "clear qi in the lower part, causing diarrhea", and it is an adjuvant medicine.

[0014] It can be known from the above explanation that the lily and polygonatum beverage formula proposed in the present invention contains lily and polygonatum, which can work together to nourish qi, nourish yin and moisten the lungs, and can effectively relieve discomfort such as fatigue and dry mouth; the raw materials contain raspberry, polygonatum and alpinia oxyphylla, which can work together to nourish the kidney, warm the spleen and moisten the lungs, and have a good therapeutic effect on yellow and foamy urine in patients with diabetes and kidney disease; the raw materials contain angelica dahurica, tangerine peel, sophora japonica seed and kudzu root, which can strengthen the spleen and resolve phlegm, regulate blood sugar and blood lipids, and relieve symptoms of liver and kidney yin deficiency in patients with early diabetes.

[0015] The present invention prepares the lily and polygonatum odoratum beverage by preparing the above raw materials according to the principle of monarch, minister, assistant and envoy formulation, and makes the lily and polygonatum odoratum beverage have the effect of nourishing the lung, spleen and kidney without stagnation, and the medicinal properties are both warm and cool, and the cold and heat are balanced. Through the comprehensive conditioning of the beverage, clinical symptoms can be alleviated, the symptoms of liver and kidney yin deficiency and the like in early diabetic patients can be alleviated, and the blood sugar and blood lipids can be reduced.

[0016] As a preferred technical solution of the lily and polygonatum beverage of the present invention, its effective ingredients are prepared from the following weights of Chinese medicinal raw materials:

[0017] Lily 12g; Polygonatum odoratum 12g; Raspberry 10g;

[0018] Polygonatum sibiricum 10g; Alpinia oxyphylla 10g; Angelica dahurica 9g;

[0019] Tangerine peel 6g; Sophora japonica seeds 6g; Pueraria root 9g.

[0020] At the same time, the present invention also proposes a preparation method of a lily and polygonatum beverage, the steps of which are as follows:

[0021] 1) Soak lily, polygonatum, raspberry, polygonatum, alpinia oxyphylla, angelica dahurica, tangerine peel, sophora japonica and kudzu root in water for 60-90 minutes;

[0022] 2) After soaking, remove the liquid, add 2 to 4 times the weight of the raw material, and heat and boil for 90 to 120 minutes;

[0023] 3) After decoction, the decoction liquid is filtered to obtain the decoction liquid, and the decoction liquid is mixed with auxiliary materials according to a preset ratio to prepare a lily and polygonatum solid or liquid beverage.

[0024] In one embodiment of the present invention, the decoction liquid and auxiliary materials are mixed uniformly according to the following weight ratios, dried and powdered to obtain a solid beverage of lily and polygonatum odoratum: 45-50% of decoction liquid, 5-10% of pectin, and 40-50% of maltodextrin. The decoction liquid can be thickened by pectin and maltodextrin, and can be seasoned to a certain extent to meet the drinking needs of patients.

[0025] In another embodiment of the present invention, the decoction liquid and the auxiliary materials are mixed and homogenized according to the following weight ratio to obtain a lily and polygonatum liquid beverage: 40-50% of the decoction liquid, 5% of the apple cider vinegar and sugar mixture, and 45-55% of purified water. The decoction liquid and purified water are mixed in approximately equal weight percentages to effectively maintain the health care effect of the lily and polygonatum beverage, and the beverage is seasoned by mixing the apple cider vinegar and sugar auxiliary materials, so that the beverage can meet the drinking needs of patients. DETAILED DESCRIPTION

[0026] The lily and polygonatum odoratum beverage of the present invention is further described in detail below in conjunction with the embodiments.

[0027] Example 1

[0028] Preparation of Lily and Polygonatum odoratum solid drink:

[0029] 1) Soak 15g lily, 15g polygonatum, 8g raspberry, 8g polygonatum, 12g alpinia oxyphylla, 8g angelica dahurica, 7g tangerine peel, 5g sophora japonica seed and 10g kudzu root in 200g water for 60min.

[0030] 2) After soaking, remove the liquid, add 260g of pure water, and heat and boil for 100 minutes.

[0031] 3) After decoction, filter to obtain the decoction liquid, mix the decoction liquid and auxiliary materials in the following weight proportion, and dry and powder: decoction liquid 100g, pectin 10g, maltodextrin 90g.

[0032] 4) Obtain 200g of lily and polygonatum solid drink, pack it into 20 bags, 10g per bag as a single dose, and take it with warm water.

[0033] Example 2

[0034] Preparation of Lily and Polygonatum odoratum liquid beverage:

[0035] 1) Soak 12g of lily, 12g of polygonatum, 10g of raspberry, 10g of polygonatum, 10g of alpinia oxyphylla, 9g of angelica dahurica, 6g of tangerine peel, 6g of sophora japonica seed and 9g of kudzu root in 200g of water for 80min.

[0036] 2) After soaking, remove the liquid, add 250g of pure water, and heat and boil for 120 minutes.

[0037] 3) After decoction, filter to obtain the decoction liquid, and mix the decoction liquid and auxiliary materials in the following weight proportions: 100g decoction liquid, 4g apple vinegar, 6g sugar, and 90g purified water.

[0038] 4) Obtain 200 g of lily and polygonatum odoratum liquid beverage, pack it into 20 bottles, 10 g per bottle as a single serving amount, and drink directly.

[0039] Example 3

[0040] Efficacy observation

[0041] The clinical efficacy of the drug was observed in 8 patients with early diabetes, once in the morning and once in the evening. Before treatment, all 8 patients had obvious symptoms of dry mouth, bitter taste, polydipsia, polyuria, polyphagia, weight loss, fatigue, and poor blood sugar control. After 4 weeks of treatment, 4 patients reported significant improvement in blurred vision, 4 patients reported significant reduction in urine foam, and 8 patients' fatigue and blood sugar levels improved.

[0042] For example, medical records: 1. Li, male, 57 years old, first diagnosed on May 25, 2021. Chief complaint: "blood sugar has been elevated for more than 18 years". The patient has recently had dry mouth and thirst, accompanied by fatigue, blurred vision, occasional nausea and vomiting, large urine volume, and foamy urine. Biochemical medium set: total protein 62.1g / L, albumin 38.9g / L, asparagine aminotransferase 11U / L, creatinine 80.7umol / L, uric acid 441umol / L, fasting glucose 9.51mmol / L, triglycerides 1.93mmol / L, cystatin C1.19mg / L, C-reactive protein 1.54mg / L. Urinalysis: urine protein 1+, urine glucose 3+, urine specific gravity ≥1.030. Glucose 2 hours after meal 20.59mmol / L. Glycated hemoglobin 9.76%. Blood routine monocyte count 0.66×10 9 / L. Western medicine diagnosis: type 2 diabetes. Traditional Chinese medicine diagnosis: diabetes mellitus (Qi Yin deficiency with blood stasis). Traditional Chinese medicine treatment: tonifying Qi and nourishing Yin, promoting blood circulation and removing blood stasis. Baihe Yuzhuyin granules (solid beverage prepared in Example 1) were given, 2 doses per day, taken in the morning and evening. The patient was also advised to adjust his diet and daily life and avoid excessive fatigue.

[0043] Re-examination on August 24, 2021. The patient's symptoms of dry mouth, thirst, fatigue, and blurred vision have improved significantly. The biochemical test showed fasting glucose of 6.74mmol / L and homocysteine ​​of 16.4umol / L. Glycated hemoglobin was 7.77%. Urinalysis: urine protein 1+, urine glucose 3+. No abnormalities were found in the blood routine test.

[0044] Medical records: 2. Wang, male, 47 years old, first diagnosed on June 20, 2021. The main complaint was that blood sugar had increased for more than 6 years, with soreness of waist and knees, frequent urination with a small amount of foam, mild edema of lower limbs, dry mouth and lips first, thirst for cold drinks, hot in the five hearts, occasional tinnitus, dry skin and local itching, good appetite and sleep, normal bowel movements. The tongue was dull with ecchymosis, thin and less fur, and fine and astringent pulse. The outpatient fasting blood sugar was 10.6mmol / L. Glycated hemoglobin HbA1c 8.1%. Urine albumin (++), 24h urine protein quantification 2.4g, urine microalbumin 68.0mg / L, urine albumin / urine creatinine 79.10mg / gC.

[0045] The western medicine diagnosis is: type 2 diabetes. The traditional Chinese medicine diagnosis is: diabetes mellitus (spleen and kidney yin deficiency with blood stasis syndrome). The traditional Chinese medicine treatment is: nourishing yin and strengthening the kidney, promoting blood circulation and removing blood stasis. Give Baihe Yuzhuyin oral liquid (liquid drink prepared in Example 2), 2 bottles per day, divided into morning and evening. At the same time, give metformin hydrochloride 0.5g bid. Gliclazide 10mg tid orally. During the medication period, the patient is advised to eat less radish, mung beans and strong tea, and fasting raw and cold food, animal offal and seafood products. Pay attention to avoiding wind and cold and clearing emotions in daily life.

[0046] Follow-up visit on September 25, 2021. After taking the medicine, the patient came back for a follow-up visit, and his fasting blood sugar was controlled at 9mmol / L, the edema of both lower limbs was significantly reduced, and the foam in urine was reduced.

[0047] The above contents are merely examples and explanations of the concept of the present invention. The technicians in this technical field may make various modifications or additions to the specific embodiments described or replace them in a similar manner. As long as they do not deviate from the concept of the invention or exceed the scope defined by the claims, they should all fall within the protection scope of the present invention.

Claims

1. A lily and polygonatum beverage, characterized in that: The active ingredients are prepared from the following Chinese medicinal raw materials by weight: Lily 10-15g; Polygonatum odoratum 10-15g; Raspberry 8-12g; Polygonatum 8-12g; Alpinia oxyphylla 8-12g; Angelica dahurica 8-10g; Tangerine peel 5-7g; Sophora japonica seeds 5-7g; Pueraria root 8-10g.

2. The lily and polygonatum odoratum beverage according to claim 1, characterized in that: The active ingredients are prepared from the following Chinese medicinal raw materials by weight: Lily 12g; Polygonatum odoratum 12g; Raspberry 10g; Polygonatum sibiricum 10g; Alpinia oxyphylla 10g; Angelica dahurica 9g; Tangerine peel 6g; Sophora japonica seeds 6g; Pueraria root 9g.

3. A method for preparing the lily and polygonatum odoratum beverage as claimed in claim 1 or 2, characterized in that: Here are the steps: 1) Soak lily, polygonatum, raspberry, polygonatum, alpinia oxyphylla, angelica dahurica, tangerine peel, sophora japonica and kudzu root in water for 60-90 minutes; 2) After soaking, remove the liquid, add 2 to 4 times the weight of the raw material, and heat and boil for 90 to 120 minutes; 3) After decoction, the decoction liquid is obtained by filtering, and the decoction liquid is mixed with auxiliary materials according to a preset ratio to prepare a solid or liquid beverage of lily and polygonatum odoratum.

4. The method according to claim 3, characterized in that The decoction and auxiliary materials are mixed evenly according to the following weight ratio, dried and powdered to obtain a lily and polygonatum solid beverage: Decoction 45-50%, pectin 5-10%, maltodextrin 40-50%.

5. The method according to claim 3, characterized in that The decoction and auxiliary materials are mixed and homogenized in the following weight proportions to obtain a lily and polygonatum liquid beverage: Decoction 40-50%, apple cider vinegar and sugar mixture 5%, purified water 45-55%.