A kind of heating paste and preparation process thereof

Abstract

The present invention relates to the technical field of heating cream production, and in particular to a heating cream and a preparation process thereof. The heating cream comprises the following raw materials: 55-65 parts by weight of water, 5-10 parts by weight of glycerol, 3-8 parts by weight of propylene glycol, 2-4 parts by weight of ginger root extract phospholipid nanoparticles, 2-4 parts by weight of cinnamon extract, 1-3 parts by weight of polyethylene glycol, 2-5 parts by weight of PEG-40 hydrogenated castor oil, 2-5 parts by weight of hydrogenated polyisobutene, 0.5-1.5 parts by weight of carbomer, 0.5-1 parts by weight of triethanolamine, 0.5-1 parts by weight of phenoxyethanol, 0.5-1 parts by weight of chitosan, 0.1-0.5 parts by weight of essence, 0.1-0.5 parts by weight of vanillyl butyl ether, 0.5-1 parts by weight of ethylhexylglycerol, and 0.5-1 parts by weight of pepper seed oil. The present invention is designed to promote the release of active ingredients such as gingerol by enzymatic hydrolysis of ginger root extract through protease, thereby enhancing the heating performance of the heating cream; and utilize phospholipid nano-loads to hydrolyze the ginger root extract to reduce the oxidation of ingredients such as gingerol and maintain the heating effect.

Description

Technical Field

[0001] The invention relates to the technical field of heating paste production, in particular to a heating paste and a preparation process thereof. Background Art

[0002] Heating cream improves local blood circulation by generating mild heat, accelerates blood flow, makes the skin and muscles feel warm, thereby relieving discomfort caused by cold and helping to reduce muscle pain and joint inflammation. However, despite the many benefits of heating cream, its potential safety issues cannot be ignored. For example, some ingredients in heating cream may cause allergic reactions to sensitive skin, including uncomfortable symptoms such as skin redness, itching and even pain. In addition, if the temperature of the heating cream is not properly controlled, it may also cause local skin overheating, causing minor burns or discomfort, affecting user experience and treatment effects. In view of this, we propose a heating cream and its preparation process. Summary of the invention

[0003] The object of the present invention is to provide a heating paste and a preparation process thereof to solve the problems raised in the above background technology.

[0004] To achieve the above object, the present invention provides a heating cream, comprising the following components: 55-65 parts by weight of water, 5-10 parts by weight of glycerin, 3-8 parts by weight of propylene glycol, 2-4 parts by weight of ginger root extract phospholipid nanoparticles, 2-4 parts by weight of cinnamon extract, 1-3 parts by weight of polyethylene glycol, 2-5 parts by weight of PEG-40 hydrogenated castor oil, 2-5 parts by weight of hydrogenated polyisobutene, 0.5-1.5 parts by weight of carbomer, 0.5-1 parts by weight of triethanolamine, 0.5-1 parts by weight of phenoxyethanol, 0.5-1 parts by weight of chitosan, 0.1-0.5 parts by weight of essence, 0.1-0.5 parts by weight of vanillyl butyl ether, 0.5-1 parts by weight of ethylhexylglycerol, and 0.5-1 parts by weight of pepper seed oil;

[0005] Among them, ginger root extract phospholipid nanoparticles are prepared by enzymatically hydrolyzing ginger root extract with protease and then loading it with phospholipids at nanoscale;

[0006] The protease is any one of papain, bromelain or trypsin.

[0007] Preferably, the ginger root extract phospholipid nanoparticles are prepared as follows:

[0008] S1.1. Weigh the following raw materials in parts by weight respectively: 10-15 parts by weight of ginger root extract, 50-60 parts by weight of phosphate buffer solution, 0.5-2.5 parts by weight of protease, 5-10 parts by weight of phospholipids, 2-5 parts by weight of cholesterol, and 10-20 parts by weight of ethanol;

[0009] S1.2, dissolving the ginger root extract in a phosphate buffer solution with a pH of 5.0-7.0, stirring with a magnetic stirrer at a speed of 100-200 rpm for 15-30 min at room temperature to obtain a ginger root extract solution with a concentration of 0.02-0.03 g / mL;

[0010] S1.3, adding protease to the ginger root extract solution and placing it in a constant temperature oscillator for enzymatic hydrolysis reaction;

[0011] S1.4, heating the reaction system in S1.3 to 85-90°C, maintaining the temperature for 5-10 minutes, and then centrifuging to obtain an enzymatically hydrolyzed ginger root extract;

[0012] The active ingredients in ginger root are often wrapped in structures such as cell walls. Proteases can hydrolyze the cell wall components of ginger root cells, such as cellulose, hemicellulose and pectin, to loosen the cell structure, which helps release the active ingredients in ginger root, such as gingerol, thereby enhancing the heating function of ginger root extract. Proteases can specifically hydrolyze peptide bonds in proteins and break them down into smaller peptides or amino acids (ginger root extracts may contain some proteins or peptides related to heating function), making it easier for them to exert heating effects.

[0013] Enzymatic hydrolysis can decompose macromolecules into smaller molecules. For the active ingredients in ginger root extract, smaller molecules are more easily absorbed and utilized by the human body. It can also improve the solubility of the active ingredients in ginger root extract, thereby improving its transmission and effect in the body. Protease itself may have a certain impact on the physiological process of the human body, thereby indirectly promoting the heating function of ginger root extract.

[0014] S1.5, dissolving phospholipids and cholesterol in 95-100% ethanol to form a phospholipid solution with a concentration of 0.5-1 g / mL; dissolving the enzymatically hydrolyzed ginger root extract in deionized water to form an aqueous phase solution;

[0015] S1.6, adding the phospholipid solution to the aqueous phase solution, and stirring vigorously using a magnetic stirrer to form a uniform primary emulsion;

[0016] S1.7, subjecting the primary emulsion to ultrasonic treatment to obtain ginger root extract phospholipid nanoparticles with a particle size of 20-80 mm;

[0017] Phospholipid nanocarriers can encapsulate the active ingredients in the ginger root extract after enzymatic hydrolysis to prevent them from being directly exposed to the external environment, and can prevent the active ingredients (such as gingerol) from being destroyed by factors, thereby improving their stability; phospholipid nanocarriers can form a barrier to prevent oxygen from contacting the easily oxidizable ingredients in the ginger root extract (such as gingerol and zingerone), thereby reducing the occurrence of oxidation reactions and maintaining the stability of its heating function;

[0018] Phospholipid nanocarriers have good biocompatibility and can interact with cell membranes to promote the absorption of active ingredients in ginger root extract, improve the bioavailability of active ingredients, and control the release rate and time of active ingredients so that they can act at a specific location or time. They can concentrate the release of ginger root extract in local areas to enhance the local heating effect.

[0019] Preferably, in S1.3, the constant temperature oscillator speed is set to 200-400 rpm, the temperature is set to 55-65° C., and the reaction time is 2-4 h.

[0020] Preferably, in S1.4, the centrifugal treatment is performed by a centrifuge, and the centrifugal speed of the centrifuge is set to 3000-5000 rpm, and the centrifugal time is 15-20 min.

[0021] Preferably, in S1.6, the stirring speed of the magnetic stirrer is 1000-2000 rpm, the stirring temperature is 40-60°C, and the stirring time is 5-10 min.

[0022] Preferably, the ultrasonic treatment time is 5-10 minutes, and the ultrasonic power is set to 200-300W.

[0023] On the other hand, the present invention provides a preparation process of a heating paste, which is used to prepare the heating paste, comprising the following steps:

[0024] S1. Weigh the following raw materials in parts by weight respectively: 55-65 parts by weight of water, 5-10 parts by weight of glycerol, 3-8 parts by weight of propylene glycol, 2-4 parts by weight of ginger root extract phospholipid nanoparticles, 2-4 parts by weight of cinnamon extract, 1-3 parts by weight of polyethylene glycol, 2-5 parts by weight of PEG-40 hydrogenated castor oil, 2-5 parts by weight of hydrogenated polyisobutene, 0.5-1.5 parts by weight of carbomer, 0.5-1 parts by weight of triethanolamine, 0.5-1 parts by weight of phenoxyethanol, 0.5-1 parts by weight of chitosan, 0.1-0.5 parts by weight of essence, 0.1-0.5 parts by weight of vanillyl butyl ether, 0.5-1 parts by weight of ethylhexylglycerol, and 0.5-1 parts by weight of pepper seed oil;

[0025] S2, mixing the cinnamon extract and PEG-40 hydrogenated castor oil and stirring them evenly to obtain a cinnamon extract emulsion with a concentration of 0.02-0.04 g / mL;

[0026] Cinnamaldehyde in cinnamon extract can activate temperature receptors on the skin, especially TRPV1 (transient receptor potential vanilloid subtype 1), which is an ion channel sensitive to heat and spicy stimulation. When these receptors are activated, they send signals to the brain, making people feel warm or hot, which can enhance the heating effect of the heating cream. The ingredients in cinnamon (cinnamic acid, cinnamyl alcohol, etc.) can also dilate blood vessels and increase blood flow, which not only helps to increase local temperature, but also accelerates the absorption and diffusion of drug ingredients, further enhancing the effect of the heating cream.

[0027] S3, mixing ginger root extract phospholipid nanoparticles with cinnamon extract emulsion, and preparing nanofibers by electrospinning, wherein the voltage of the electrospinning machine is set to 10-30 kV, the flow rate is set to 0.1-1 mL / h, and the distance from the spinneret to the receiver is set to 10-30 cm;

[0028] The nanofibers are collected on a receiver to form a nanofiber membrane, and then dried. The drying temperature is set to 30-60°C and the drying time is 1-3h.

[0029] The dried nanofiber membrane was cut into small pieces and added into water, and then dispersed into a suspension using ultrasound. The power of the ultrasound was set at 100-1000W and the treatment time was set at 0.5-1h.

[0030] Adding polyethylene glycol to the suspension, and homogenizing using a homogenizer at 40-50° C. and a speed of 10000-15000 rpm for 10-15 minutes to form a composite emulsion;

[0031] Gingerol and other ingredients in ginger root extract phospholipid nanoparticles also bind to TRPV1 channels on the skin surface and activate these receptors. Activated TRPV1 channels lead to calcium ion influx, triggering the release of neurotransmitters at nerve endings, sending warming signals to the brain. Cinnamaldehyde and gingerol activate TRPV1 channels on vascular smooth muscle cells, causing vasodilation, which increases local blood flow, raises local temperature, and enhances the heating effect. The composite emulsion of cinnamon extract and ginger root extract wrapped in phospholipid nanoparticles penetrates the stratum corneum of the skin through its good lipophilicity and hydrophilicity. The warming effect further promotes the penetration of phospholipid nanoparticles, allowing the drug to reach the site of action more effectively.

[0032] S4, mixing water, glycerin and propylene glycol, heating and stirring with a magnetic stirrer, and after stirring evenly, adding carbomer at 0.1-0.2 parts by weight per minute, stirring at a speed of 200-400 rpm for 30-60 minutes to allow the carbomer to swell completely;

[0033] S5, stirring hydrogenated polyisobutene, pepper seed oil, triethanolamine, phenoxyethanol, ethylhexylglycerin, chitosan, flavor and vanillyl butyl ether with a magnetic stirrer at 40-50° C. and at a speed of 200-300 rpm for 15-30 min to obtain a mixed solution;

[0034] S6, adding the composite emulsion in S3 to S4, stirring with a magnetic stirrer at 40-50°C and 600-800 rpm for 15-30 min; then adding the mixed solution in S5 and continuing stirring;

[0035] S7. Finally, use a homogenizer to homogenize 3-5 times at a pressure of 20-50 MPa to obtain a heating paste.

[0036] Preferably, in S2, the stirring temperature of the magnetic stirrer is 40-50°C, the stirring speed is 1000-2000rpm, and the stirring time is 10-15min.

[0037] Preferably, in S4, the stirring temperature of the magnetic stirrer is 40-50°C, the stirring speed is 200-300 rpm, and the stirring time is 10-15 min.

[0038] Preferably, in S6, continuous stirring is performed using a magnetic stirrer, the stirring temperature is 40-50°C, the stirring speed is 1000-1500 rpm, and the stirring time is 10-20 min.

[0039] Compared with the prior art, the present invention has the following beneficial effects:

[0040] 1. In the heating cream and its preparation process, protease is used to enzymatically hydrolyze the ginger root extract. Since the active ingredients in the ginger root (such as gingerol, etc.) are often wrapped in structures such as cell walls, the protease can hydrolyze the cell wall components of the ginger root cells, which is conducive to the release of active ingredients such as gingerol, thereby enhancing the heating function of the ginger root extract; the phospholipid nanocarrier can form a barrier to prevent oxygen from contacting the easily oxidized components in the ginger root extract (such as gingerol and zingerone), reduce the occurrence of oxidation reactions, maintain the stability of its heating function, and can also allow the ginger root extract to be concentratedly released in a local area to enhance the local heating effect.

[0041] 2. Cinnamon extract is added to the heating cream and its preparation process because cinnamaldehyde in cinnamon extract can activate the temperature receptors on the skin, especially TRPV1 (transient receptor potential vanilloid subtype 1), which is an ion channel sensitive to heat and spicy stimulation. When these receptors are activated, they send signals to the brain, making people feel warm or hot, which can enhance the heating effect of the heating cream. The ingredients in cinnamon (cinnamic acid, cinnamyl alcohol, etc.) can also dilate blood vessels and increase blood flow, which not only helps to increase local temperature, but also accelerates the absorption and diffusion of drug ingredients, further enhancing the effect of the heating cream. DETAILED DESCRIPTION

[0042] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0043] The heating cream of the present invention comprises the following raw materials: 55-65 parts by weight of water, 5-10 parts by weight of glycerol, 3-8 parts by weight of propylene glycol, 2-4 parts by weight of ginger root extract phospholipid nanoparticles, 2-4 parts by weight of cinnamon extract, 1-3 parts by weight of polyethylene glycol, 2-5 parts by weight of PEG-40 hydrogenated castor oil, 2-5 parts by weight of hydrogenated polyisobutene, 0.5-1.5 parts by weight of carbomer, 0.5-1 parts by weight of triethanolamine, 0.5-1 parts by weight of phenoxyethanol, 0.5-1 parts by weight of chitosan, 0.1-0.5 parts by weight of essence, 0.1-0.5 parts by weight of vanillyl butyl ether, 0.5-1 parts by weight of ethylhexylglycerol, and 0.5-1 parts by weight of pepper seed oil;

[0044] Among them, ginger root extract phospholipid nanoparticles are prepared by enzymatically hydrolyzing ginger root extract with protease and then loading it with phospholipids at nanoscale;

[0045] A preferred protease is papain.

[0046] Embodiment 1: A process for preparing a heating paste, comprising the following steps:

[0047] S1. Weigh the following raw materials in parts by weight respectively: 60 parts by weight of water, 8 parts by weight of glycerol, 6 parts by weight of propylene glycol, 3 parts by weight of ginger root extract phospholipid nanoparticles, 3 parts by weight of cinnamon extract, 2 parts by weight of polyethylene glycol, 3 parts by weight of PEG-40 hydrogenated castor oil, 3 parts by weight of hydrogenated polyisobutene, 1 part by weight of carbomer, 0.8 parts by weight of triethanolamine, 0.8 parts by weight of phenoxyethanol, 1 part by weight of chitosan, 0.3 parts by weight of essence, 0.3 parts by weight of vanillyl butyl ether, 0.8 parts by weight of ethylhexylglycerol, and 0.8 parts by weight of pepper seed oil;

[0048] S2, mixing the cinnamon extract with PEG-40 hydrogenated castor oil, stirring with a magnetic stirrer, the stirring temperature is 45° C., the stirring speed is 1500 rpm, and the stirring time is 15 min to obtain a cinnamon extract emulsion with a concentration of 0.03 g / mL;

[0049] S3, mixing ginger root extract phospholipid nanoparticles with cinnamon extract emulsion, and preparing nanofibers by electrospinning, wherein the voltage of the electrospinning machine is set to 20 kV, the flow rate is set to 0.5 mL / h, and the distance from the spinneret to the receiver is set to 20 cm;

[0050] The nanofibers were collected on a receiver to form a nanofiber membrane, and then dried at a temperature of 50°C for 3 hours.

[0051] The dried nanofiber membrane was cut into small pieces and added into water, and then dispersed into a suspension using ultrasound. The power of the ultrasound was set at 500 W and the treatment time was set at 1 h.

[0052] Add polyethylene glycol to the suspension, and homogenize using a homogenizer at 45°C and 12000 rpm for 10 min to form a composite emulsion;

[0053] S4, mixing water, glycerin and propylene glycol, heating and stirring with a magnetic stirrer, the stirring temperature is 45°C, the stirring speed is 300 rpm, and the stirring time is 15 min; after stirring evenly, adding carbomer at 0.1 parts by weight per minute, stirring at a speed of 300 rpm for 40 min to allow the carbomer to swell completely;

[0054] S5, stirring hydrogenated polyisobutene, pepper seed oil, triethanolamine, phenoxyethanol, ethylhexylglycerin, chitosan, flavor and vanillyl butyl ether with a magnetic stirrer at 45° C. and 300 rpm for 20 min to obtain a mixed solution;

[0055] S6, adding the composite emulsion in S3 to S4, stirring with a magnetic stirrer at 40°C and 800 rpm for 20 min; then adding the mixed solution in S5, stirring continuously with a magnetic stirrer, the stirring temperature is 40°C, the stirring speed is 1200 rpm, and the stirring time is 20 min;

[0056] S7. Finally, use a homogenizer to homogenize 4 times at a pressure of 25 MPa to obtain a heating paste.

[0057] The ginger root extract phospholipid nanoparticles were prepared as follows:

[0058] S1.1. Weigh the following raw materials in parts by weight: 12 parts by weight of ginger root extract, 55 parts by weight of phosphate buffer solution, 1.2 parts by weight of papain, 8 parts by weight of phospholipids, 3 parts by weight of cholesterol, and 15 parts by weight of ethanol;

[0059] S1.2, dissolving the ginger root extract in phosphate buffer (pH 6.0), stirring with a magnetic stirrer at 200 rpm for 15 min at room temperature to obtain a ginger root extract solution with a concentration of 0.024 g / mL;

[0060] S1.3, the papain was added to the ginger root extract solution in a constant temperature oscillator, the constant temperature oscillator at a speed of 200rpm, the temperature was 55 ℃, the enzymatic reaction, the reaction time was 4h;

[0061] S1.4, heating the reaction system of S1.3 to 90°C, maintaining the temperature for 8 minutes, and then centrifuging at a speed of 3000 rpm for 15 minutes to obtain an enzymatically hydrolyzed ginger root extract;

[0062] S1.5, dissolving phospholipids and cholesterol in 95% ethanol to form a phospholipid solution with a concentration of 0.8 g / mL; dissolving the enzymatically hydrolyzed ginger root extract in deionized water to form an aqueous phase solution;

[0063] S1.6, adding the phospholipid solution to the aqueous phase solution, stirring vigorously with a stirrer at a speed of 1200 rpm and a temperature of 50°C for 10 min to form a uniform primary emulsion;

[0064] S1.7. The primary emulsion was subjected to ultrasonic treatment at a power of 200 W for 5 min to obtain ginger root extract phospholipid nanoparticles with a particle size of 60 mm.

[0065] Embodiment 2: A process for preparing a heating paste, comprising the following steps:

[0066] S1. Weigh the following raw materials in parts by weight respectively: 60 parts by weight of water, 8 parts by weight of glycerol, 6 parts by weight of propylene glycol, 3 parts by weight of ginger root extract phospholipid nanoparticles, 3 parts by weight of cinnamon extract, 2 parts by weight of polyethylene glycol, 3 parts by weight of PEG-40 hydrogenated castor oil, 3 parts by weight of hydrogenated polyisobutene, 1 part by weight of carbomer, 0.8 parts by weight of triethanolamine, 0.8 parts by weight of phenoxyethanol, 1 part by weight of chitosan, 0.3 parts by weight of essence, 0.3 parts by weight of vanillyl butyl ether, 0.8 parts by weight of ethylhexylglycerol, and 0.8 parts by weight of pepper seed oil;

[0067] S2, mixing the cinnamon extract with PEG-40 hydrogenated castor oil, stirring with a magnetic stirrer, the stirring temperature is 45° C., the stirring speed is 1500 rpm, and the stirring time is 15 min to obtain a cinnamon extract emulsion with a concentration of 0.03 g / mL;

[0068] S3, mixing ginger root extract phospholipid nanoparticles with cinnamon extract emulsion, and preparing nanofibers by electrospinning, wherein the voltage of the electrospinning machine is set to 20 kV, the flow rate is set to 0.5 mL / h, and the distance from the spinneret to the receiver is set to 20 cm;

[0069] The nanofibers were collected on a receiver to form a nanofiber membrane, and then dried at a temperature of 50°C for 3 hours.

[0070] The dried nanofiber membrane was cut into small pieces and added into water, and then dispersed into a suspension using ultrasound. The power of the ultrasound was set at 500 W and the treatment time was set at 1 h.

[0071] Add polyethylene glycol to the suspension, and homogenize using a homogenizer at 45°C and 12000 rpm for 10 min to form a composite emulsion;

[0072] S4, mixing water, glycerin and propylene glycol, heating and stirring with a magnetic stirrer, the stirring temperature is 45°C, the stirring speed is 300 rpm, and the stirring time is 15 min; after stirring evenly, adding carbomer at 0.1 parts by weight per minute, stirring at a speed of 300 rpm for 40 min to allow the carbomer to swell completely;

[0073] S5, stirring hydrogenated polyisobutene, pepper seed oil, triethanolamine, phenoxyethanol, ethylhexylglycerin, chitosan, flavor and vanillyl butyl ether with a magnetic stirrer at 45° C. and 300 rpm for 20 min to obtain a mixed solution;

[0074] S6, adding the composite emulsion in S3 to S4, stirring with a magnetic stirrer at 40°C and 800 rpm for 20 min; then adding the mixed solution in S5, stirring continuously with a magnetic stirrer, the stirring temperature is 40°C, the stirring speed is 1200 rpm, and the stirring time is 20 min;

[0075] S7. Finally, use a homogenizer to homogenize 4 times at a pressure of 25 MPa to obtain a heating paste.

[0076] The ginger root extract phospholipid nanoparticles were prepared as follows:

[0077] S1.1. Weigh the following raw materials in parts by weight: 12 parts by weight of ginger root extract, 55 parts by weight of phosphate buffer solution, 1.44 parts by weight of papain, 8 parts by weight of phospholipids, 3 parts by weight of cholesterol, and 15 parts by weight of ethanol;

[0078] S1.2, dissolving the ginger root extract in phosphate buffer (pH 6.0), stirring with a magnetic stirrer at 200 rpm for 15 min at room temperature to obtain a ginger root extract solution with a concentration of 0.024 g / mL;

[0079] S1.3, the papain was added to the ginger root extract solution in a constant temperature oscillator, the constant temperature oscillator at a speed of 200rpm, the temperature was 55 ℃, the enzymatic reaction, the reaction time was 4h;

[0080] S1.4, heating the reaction system of S1.3 to 90°C, maintaining the temperature for 8 minutes, and then centrifuging at a speed of 3000 rpm for 15 minutes to obtain an enzymatically hydrolyzed ginger root extract;

[0081] S1.5, dissolving phospholipids and cholesterol in 95% ethanol to form a phospholipid solution with a concentration of 0.8 g / mL; dissolving the enzymatically hydrolyzed ginger root extract in deionized water to form an aqueous phase solution;

[0082] S1.6, adding the phospholipid solution to the aqueous phase solution, stirring vigorously with a stirrer at a speed of 1200 rpm and a temperature of 50°C for 10 min to form a uniform primary emulsion;

[0083] S1.7. The primary emulsion was subjected to ultrasonic treatment at a power of 200 W for 5 min to obtain ginger root extract phospholipid nanoparticles with a particle size of 60 mm.

[0084] Embodiment 3: A process for preparing a heating paste, comprising the following steps:

[0085] S1. Weigh the following raw materials in parts by weight respectively: 60 parts by weight of water, 8 parts by weight of glycerol, 6 parts by weight of propylene glycol, 3 parts by weight of ginger root extract phospholipid nanoparticles, 3 parts by weight of cinnamon extract, 2 parts by weight of polyethylene glycol, 3 parts by weight of PEG-40 hydrogenated castor oil, 3 parts by weight of hydrogenated polyisobutene, 1 part by weight of carbomer, 0.8 parts by weight of triethanolamine, 0.8 parts by weight of phenoxyethanol, 1 part by weight of chitosan, 0.3 parts by weight of essence, 0.3 parts by weight of vanillyl butyl ether, 0.8 parts by weight of ethylhexylglycerol, and 0.8 parts by weight of pepper seed oil;

[0086] S2, mixing the cinnamon extract with PEG-40 hydrogenated castor oil, stirring with a magnetic stirrer, the stirring temperature is 45° C., the stirring speed is 1500 rpm, and the stirring time is 15 min to obtain a cinnamon extract emulsion with a concentration of 0.03 g / mL;

[0087] S3, mixing ginger root extract phospholipid nanoparticles with cinnamon extract emulsion, and preparing nanofibers by electrospinning, wherein the voltage of the electrospinning machine is set to 20 kV, the flow rate is set to 0.5 mL / h, and the distance from the spinneret to the receiver is set to 20 cm;

[0088] The nanofibers were collected on a receiver to form a nanofiber membrane, and then dried at a temperature of 50°C for 3 hours.

[0089] The dried nanofiber membrane was cut into small pieces and added into water, and then dispersed into a suspension using ultrasound. The power of the ultrasound was set at 500 W and the treatment time was set at 1 h.

[0090] Add polyethylene glycol to the suspension, and homogenize using a homogenizer at 45°C and 12000 rpm for 10 min to form a composite emulsion;

[0091] S4, mixing water, glycerin and propylene glycol, heating and stirring with a magnetic stirrer, the stirring temperature is 45°C, the stirring speed is 300 rpm, and the stirring time is 15 min; after stirring evenly, adding carbomer at 0.1 parts by weight per minute, stirring at a speed of 300 rpm for 40 min to allow the carbomer to swell completely;

[0092] S5, stirring hydrogenated polyisobutene, pepper seed oil, triethanolamine, phenoxyethanol, ethylhexylglycerin, chitosan, flavor and vanillyl butyl ether with a magnetic stirrer at 45° C. and 300 rpm for 20 min to obtain a mixed solution;

[0093] S6, adding the composite emulsion in S3 to S4, stirring with a magnetic stirrer at 40°C and 800 rpm for 20 min; then adding the mixed solution in S5, stirring continuously with a magnetic stirrer, the stirring temperature is 40°C, the stirring speed is 1200 rpm, and the stirring time is 20 min;

[0094] S7. Finally, use a homogenizer to homogenize 4 times at a pressure of 25 MPa to obtain a heating paste.

[0095] The ginger root extract phospholipid nanoparticles were prepared as follows:

[0096] S1.1. Weigh the following raw materials in parts by weight: 12 parts by weight of ginger root extract, 55 parts by weight of phosphate buffer solution, 1.8 parts by weight of papain, 8 parts by weight of phospholipids, 3 parts by weight of cholesterol, and 15 parts by weight of ethanol;

[0097] S1.2, dissolving the ginger root extract in phosphate buffer (pH 6.0), stirring with a magnetic stirrer at 200 rpm for 15 min at room temperature to obtain a ginger root extract solution with a concentration of 0.024 g / mL;

[0098] S1.3, the papain was added to the ginger root extract solution in a constant temperature oscillator, the constant temperature oscillator at a speed of 200rpm, the temperature was 55 ℃, the enzymatic reaction, the reaction time was 4h;

[0099] S1.4, heating the reaction system of S1.3 to 90°C, maintaining the temperature for 8 minutes, and then centrifuging at a speed of 3000 rpm for 15 minutes to obtain an enzymatically hydrolyzed ginger root extract;

[0100] S1.5, dissolving phospholipids and cholesterol in 95% ethanol to form a phospholipid solution with a concentration of 0.8 g / mL; dissolving the enzymatically hydrolyzed ginger root extract in deionized water to form an aqueous phase solution;

[0101] S1.6, adding the phospholipid solution to the aqueous phase solution, stirring vigorously with a stirrer at a speed of 1200 rpm and a temperature of 50°C for 10 min to form a uniform primary emulsion;

[0102] S1.7. The primary emulsion was subjected to ultrasonic treatment at a power of 200 W for 5 min to obtain ginger root extract phospholipid nanoparticles with a particle size of 60 mm.

[0103] Embodiment 4: A process for preparing a heating paste, comprising the following steps:

[0104] S1. Weigh the following raw materials in parts by weight respectively: 60 parts by weight of water, 8 parts by weight of glycerol, 6 parts by weight of propylene glycol, 3 parts by weight of ginger root extract phospholipid nanoparticles, 3 parts by weight of cinnamon extract, 2 parts by weight of polyethylene glycol, 3 parts by weight of PEG-40 hydrogenated castor oil, 3 parts by weight of hydrogenated polyisobutene, 1 part by weight of carbomer, 0.8 parts by weight of triethanolamine, 0.8 parts by weight of phenoxyethanol, 1 part by weight of chitosan, 0.3 parts by weight of essence, 0.3 parts by weight of vanillyl butyl ether, 0.8 parts by weight of ethylhexylglycerol, and 0.8 parts by weight of pepper seed oil;

[0105] S2, mixing the cinnamon extract with PEG-40 hydrogenated castor oil, stirring with a magnetic stirrer, the stirring temperature is 45° C., the stirring speed is 1500 rpm, and the stirring time is 15 min to obtain a cinnamon extract emulsion with a concentration of 0.03 g / mL;

[0106] S3, mixing ginger root extract phospholipid nanoparticles with cinnamon extract emulsion, and preparing nanofibers by electrospinning, wherein the voltage of the electrospinning machine is set to 20 kV, the flow rate is set to 0.5 mL / h, and the distance from the spinneret to the receiver is set to 20 cm;

[0107] The nanofibers were collected on a receiver to form a nanofiber membrane, and then dried at a temperature of 50°C for 3 hours.

[0108] The dried nanofiber membrane was cut into small pieces and added into water, and then dispersed into a suspension using ultrasound. The power of the ultrasound was set at 500 W and the treatment time was set at 1 h.

[0109] Add polyethylene glycol to the suspension, and homogenize using a homogenizer at 45°C and 12000 rpm for 10 min to form a composite emulsion;

[0110] S4, mixing water, glycerin and propylene glycol, heating and stirring with a magnetic stirrer, the stirring temperature is 45°C, the stirring speed is 300 rpm, and the stirring time is 15 min; after stirring evenly, adding carbomer at 0.1 parts by weight per minute, stirring at a speed of 300 rpm for 40 min to allow the carbomer to swell completely;

[0111] S5, stirring hydrogenated polyisobutene, pepper seed oil, triethanolamine, phenoxyethanol, ethylhexylglycerin, chitosan, flavor and vanillyl butyl ether with a magnetic stirrer at 45° C. and 300 rpm for 20 min to obtain a mixed solution;

[0112] S6, adding the composite emulsion in S3 to S4, stirring with a magnetic stirrer at 40°C and 800 rpm for 20 min; then adding the mixed solution in S5, stirring continuously with a magnetic stirrer, the stirring temperature is 40°C, the stirring speed is 1200 rpm, and the stirring time is 20 min;

[0113] S7. Finally, use a homogenizer to homogenize 4 times at a pressure of 25 MPa to obtain a heating paste.

[0114] The ginger root extract phospholipid nanoparticles were prepared as follows:

[0115] S1.1. Weigh the following raw materials in parts by weight: 10 parts by weight of ginger root extract, 55 parts by weight of phosphate buffer solution, 1.2 parts by weight of papain, 8 parts by weight of phospholipids, 3 parts by weight of cholesterol, and 15 parts by weight of ethanol;

[0116] S1.2, dissolving the ginger root extract in phosphate buffer (pH 6.0), stirring with a magnetic stirrer at 200 rpm for 15 min at room temperature to obtain a ginger root extract solution with a concentration of 0.02 g / mL;

[0117] S1.3, the papain was added to the ginger root extract solution in a constant temperature oscillator, the constant temperature oscillator at a speed of 200rpm, the temperature was 55 ℃, the enzymatic reaction, the reaction time was 4h;

[0118] S1.4, heating the reaction system of S1.3 to 90°C, maintaining the temperature for 8 minutes, and then centrifuging at a speed of 3000 rpm for 15 minutes to obtain an enzymatically hydrolyzed ginger root extract;

[0119] S1.5, dissolving phospholipids and cholesterol in 95% ethanol to form a phospholipid solution with a concentration of 0.8 g / mL; dissolving the enzymatically hydrolyzed ginger root extract in deionized water to form an aqueous phase solution;

[0120] S1.6, adding the phospholipid solution to the aqueous phase solution, stirring vigorously with a stirrer at a speed of 1200 rpm and a temperature of 50°C for 10 min to form a uniform primary emulsion;

[0121] S1.7. The primary emulsion was subjected to ultrasonic treatment at a power of 200 W for 5 min to obtain ginger root extract phospholipid nanoparticles with a particle size of 60 mm.

[0122] Embodiment 5: A process for preparing a heating paste, comprising the following steps:

[0123] S1. Weigh the following raw materials in parts by weight respectively: 60 parts by weight of water, 8 parts by weight of glycerol, 6 parts by weight of propylene glycol, 3 parts by weight of ginger root extract phospholipid nanoparticles, 3 parts by weight of cinnamon extract, 2 parts by weight of polyethylene glycol, 3 parts by weight of PEG-40 hydrogenated castor oil, 3 parts by weight of hydrogenated polyisobutene, 1 part by weight of carbomer, 0.8 parts by weight of triethanolamine, 0.8 parts by weight of phenoxyethanol, 1 part by weight of chitosan, 0.3 parts by weight of essence, 0.3 parts by weight of vanillyl butyl ether, 0.8 parts by weight of ethylhexylglycerol, and 0.8 parts by weight of pepper seed oil;

[0124] S2, mixing the cinnamon extract with PEG-40 hydrogenated castor oil, stirring with a magnetic stirrer, the stirring temperature is 45° C., the stirring speed is 1500 rpm, and the stirring time is 15 min to obtain a cinnamon extract emulsion with a concentration of 0.03 g / mL;

[0125] S3, mixing ginger root extract phospholipid nanoparticles with cinnamon extract emulsion, and preparing nanofibers by electrospinning, wherein the voltage of the electrospinning machine is set to 20 kV, the flow rate is set to 0.5 mL / h, and the distance from the spinneret to the receiver is set to 20 cm;

[0126] The nanofibers were collected on a receiver to form a nanofiber membrane, and then dried at a temperature of 50°C for 3 hours.

[0127] The dried nanofiber membrane was cut into small pieces and added into water, and then dispersed into a suspension using ultrasound. The power of the ultrasound was set at 500 W and the treatment time was set at 1 h.

[0128] Add polyethylene glycol to the suspension, and homogenize using a homogenizer at 45°C and 12000 rpm for 10 min to form a composite emulsion;

[0129] S4, mixing water, glycerin and propylene glycol, heating and stirring with a magnetic stirrer, the stirring temperature is 45°C, the stirring speed is 300 rpm, and the stirring time is 15 min; after stirring evenly, adding carbomer at 0.1 parts by weight per minute, stirring at a speed of 300 rpm for 40 min to allow the carbomer to swell completely;

[0130] S5, stirring hydrogenated polyisobutene, pepper seed oil, triethanolamine, phenoxyethanol, ethylhexylglycerin, chitosan, flavor and vanillyl butyl ether with a magnetic stirrer at 45° C. and 300 rpm for 20 min to obtain a mixed solution;

[0131] S6, adding the composite emulsion in S3 to S4, stirring with a magnetic stirrer at 40°C and 800 rpm for 20 min; then adding the mixed solution in S5, stirring continuously with a magnetic stirrer, the stirring temperature is 40°C, the stirring speed is 1200 rpm, and the stirring time is 20 min;

[0132] S7. Finally, use a homogenizer to homogenize 4 times at a pressure of 25 MPa to obtain a heating paste.

[0133] The ginger root extract phospholipid nanoparticles were prepared as follows:

[0134] S1.1. Weigh the following raw materials in parts by weight: 12 parts by weight of ginger root extract, 55 parts by weight of phosphate buffer solution, 1.44 parts by weight of papain, 5 parts by weight of phospholipids, 3 parts by weight of cholesterol, and 15 parts by weight of ethanol;

[0135] S1.2, dissolving the ginger root extract in phosphate buffer (pH 6.0), stirring with a magnetic stirrer at 200 rpm for 15 min at room temperature to obtain a ginger root extract solution with a concentration of 0.024 g / mL;

[0136] S1.3, the papain was added to the ginger root extract solution in a constant temperature oscillator, the constant temperature oscillator at a speed of 200rpm, the temperature was 55 ℃, the enzymatic reaction, the reaction time was 4h;

[0137] S1.4, heating the reaction system of S1.3 to 90°C, maintaining the temperature for 8 minutes, and then centrifuging at a speed of 3000 rpm for 15 minutes to obtain an enzymatically hydrolyzed ginger root extract;

[0138] S1.5, dissolving phospholipids and cholesterol in 95% ethanol to form a phospholipid solution with a concentration of 0.5 g / mL; dissolving the enzymatically hydrolyzed ginger root extract in deionized water to form an aqueous phase solution;

[0139] S1.6, adding the phospholipid solution to the aqueous phase solution, stirring vigorously with a stirrer at a speed of 1200 rpm and a temperature of 50°C for 10 min to form a uniform primary emulsion;

[0140] S1.7. The primary emulsion was subjected to ultrasonic treatment at a power of 200 W for 5 min to obtain ginger root extract phospholipid nanoparticles with a particle size of 60 mm.

[0141] Embodiment 6: A process for preparing a heating paste, comprising the following steps:

[0142] S1. Weigh the following raw materials in parts by weight respectively: 60 parts by weight of water, 8 parts by weight of glycerol, 6 parts by weight of propylene glycol, 3 parts by weight of ginger root extract phospholipid nanoparticles, 2 parts by weight of cinnamon extract, 2 parts by weight of polyethylene glycol, 3 parts by weight of PEG-40 hydrogenated castor oil, 3 parts by weight of hydrogenated polyisobutene, 1 part by weight of carbomer, 0.8 parts by weight of triethanolamine, 0.8 parts by weight of phenoxyethanol, 1 part by weight of chitosan, 0.3 parts by weight of essence, 0.3 parts by weight of vanillyl butyl ether, 0.8 parts by weight of ethylhexylglycerin, and 0.8 parts by weight of pepper seed oil;

[0143] S2, mixing the cinnamon extract with PEG-40 hydrogenated castor oil, stirring with a magnetic stirrer, the stirring temperature is 45° C., the stirring speed is 1500 rpm, and the stirring time is 15 min to obtain a cinnamon extract emulsion with a concentration of 0.02 g / mL;

[0144] S3, mixing ginger root extract phospholipid nanoparticles with cinnamon extract emulsion, and preparing nanofibers by electrospinning, wherein the voltage of the electrospinning machine is set to 20 kV, the flow rate is set to 0.5 mL / h, and the distance from the spinneret to the receiver is set to 20 cm;

[0145] The nanofibers were collected on a receiver to form a nanofiber membrane, and then dried at a temperature of 50°C for 3 hours.

[0146] The dried nanofiber membrane was cut into small pieces and added into water, and then dispersed into a suspension using ultrasound. The power of the ultrasound was set at 500 W and the treatment time was set at 1 h.

[0147] Add polyethylene glycol to the suspension, and homogenize using a homogenizer at 45°C and 12000 rpm for 10 min to form a composite emulsion;

[0148] S4, mixing water, glycerin and propylene glycol, heating and stirring with a magnetic stirrer, the stirring temperature is 45°C, the stirring speed is 300 rpm, and the stirring time is 15 min; after stirring evenly, adding carbomer at 0.1 parts by weight per minute, stirring at a speed of 300 rpm for 40 min to allow the carbomer to swell completely;

[0149] S5, stirring hydrogenated polyisobutene, pepper seed oil, triethanolamine, phenoxyethanol, ethylhexylglycerin, chitosan, flavor and vanillyl butyl ether with a magnetic stirrer at 45° C. and 300 rpm for 20 min to obtain a mixed solution;

[0150] S6, adding the composite emulsion in S3 to S4, stirring with a magnetic stirrer at 40°C and 800 rpm for 20 min; then adding the mixed solution in S5, stirring continuously with a magnetic stirrer, the stirring temperature is 40°C, the stirring speed is 1200 rpm, and the stirring time is 20 min;

[0151] S7. Finally, use a homogenizer to homogenize 4 times at a pressure of 25 MPa to obtain a heating paste.

[0152] The ginger root extract phospholipid nanoparticles were prepared as follows:

[0153] S1.1. Weigh the following raw materials in parts by weight: 12 parts by weight of ginger root extract, 55 parts by weight of phosphate buffer solution, 1.44 parts by weight of papain, 8 parts by weight of phospholipids, 3 parts by weight of cholesterol, and 15 parts by weight of ethanol;

[0154] S1.2, dissolving the ginger root extract in phosphate buffer (pH 6.0), stirring with a magnetic stirrer at 200 rpm for 15 min at room temperature to obtain a ginger root extract solution with a concentration of 0.024 g / mL;

[0155] S1.3, the papain was added to the ginger root extract solution in a constant temperature oscillator, the constant temperature oscillator at a speed of 200rpm, the temperature was 55 ℃, the enzymatic reaction, the reaction time was 4h;

[0156] S1.4, heating the reaction system of S1.3 to 90°C, maintaining the temperature for 8 minutes, and then centrifuging at a speed of 3000 rpm for 15 minutes to obtain an enzymatically hydrolyzed ginger root extract;

[0157] S1.5, dissolving phospholipids and cholesterol in 95% ethanol to form a phospholipid solution with a concentration of 0.8 g / mL; dissolving the enzymatically hydrolyzed ginger root extract in deionized water to form an aqueous phase solution;

[0158] S1.6, adding the phospholipid solution to the aqueous phase solution, stirring vigorously with a stirrer at a speed of 1200 rpm and a temperature of 50°C for 10 min to form a uniform primary emulsion;

[0159] S1.7. The primary emulsion was subjected to ultrasonic treatment at a power of 200 W for 5 min to obtain ginger root extract phospholipid nanoparticles with a particle size of 60 mm.

[0160] Embodiment 7: A process for preparing a heating paste, comprising the following steps:

[0161] S1. Weigh the following raw materials in parts by weight respectively: 60 parts by weight of water, 8 parts by weight of glycerol, 6 parts by weight of propylene glycol, 3 parts by weight of ginger root extract phospholipid nanoparticles, 3 parts by weight of cinnamon extract, 2 parts by weight of polyethylene glycol, 3 parts by weight of PEG-40 hydrogenated castor oil, 3 parts by weight of hydrogenated polyisobutene, 1 part by weight of carbomer, 0.8 parts by weight of triethanolamine, 0.8 parts by weight of phenoxyethanol, 1 part by weight of chitosan, 0.3 parts by weight of essence, 0.3 parts by weight of vanillyl butyl ether, 0.8 parts by weight of ethylhexylglycerol, and 0.8 parts by weight of pepper seed oil;

[0162] S2, mixing the cinnamon extract with PEG-40 hydrogenated castor oil, stirring with a magnetic stirrer, the stirring temperature is 45° C., the stirring speed is 1500 rpm, and the stirring time is 15 min to obtain a cinnamon extract emulsion with a concentration of 0.03 g / mL;

[0163] S3, mixing ginger root extract phospholipid nanoparticles with cinnamon extract emulsion, and preparing nanofibers by electrospinning, wherein the voltage of the electrospinning machine is set to 20 kV, the flow rate is set to 0.5 mL / h, and the distance from the spinneret to the receiver is set to 20 cm;

[0164] The nanofibers were collected on a receiver to form a nanofiber membrane, and then dried at a temperature of 50°C for 3 hours.

[0165] The dried nanofiber membrane was cut into small pieces and added into water, and then dispersed into a suspension using ultrasound. The power of the ultrasound was set at 500 W and the treatment time was set at 1 h.

[0166] Add polyethylene glycol to the suspension, and homogenize using a homogenizer at 45°C and 12000 rpm for 10 min to form a composite emulsion;

[0167] S4, mixing water, glycerin and propylene glycol, heating and stirring with a magnetic stirrer, the stirring temperature is 45°C, the stirring speed is 300 rpm, and the stirring time is 15 min; after stirring evenly, adding carbomer at 0.1 parts by weight per minute, stirring at a speed of 300 rpm for 40 min to allow the carbomer to swell completely;

[0168] S5, stirring hydrogenated polyisobutene, pepper seed oil, triethanolamine, phenoxyethanol, ethylhexylglycerin, chitosan, flavor and vanillyl butyl ether with a magnetic stirrer at 45° C. and 300 rpm for 20 min to obtain a mixed solution;

[0169] S6, adding the composite emulsion in S3 to S4, stirring with a magnetic stirrer at 40°C and 800 rpm for 20 min; then adding the mixed solution in S5, stirring continuously with a magnetic stirrer, the stirring temperature is 40°C, the stirring speed is 1200 rpm, and the stirring time is 20 min;

[0170] S7. Finally, use a homogenizer to homogenize 4 times at a pressure of 25 MPa to obtain a heating paste.

[0171] The ginger root extract phospholipid nanoparticles were prepared as follows:

[0172] S1.1. Weigh the following raw materials in parts by weight: 12 parts by weight of ginger root extract, 50 parts by weight of phosphate buffer solution, 1.44 parts by weight of papain, 8 parts by weight of phospholipids, 3 parts by weight of cholesterol, and 10 parts by weight of ethanol;

[0173] S1.2, dissolving the ginger root extract in phosphate buffer (pH 6.0), stirring with a magnetic stirrer at 200 rpm for 15 min at room temperature to obtain a ginger root extract solution with a concentration of 0.03 g / mL;

[0174] S1.3, the papain was added to the ginger root extract solution in a constant temperature oscillator, the constant temperature oscillator at a speed of 200rpm, the temperature was 55 ℃, the enzymatic reaction, the reaction time was 4h;

[0175] S1.4, heating the reaction system of S1.3 to 90°C, maintaining the temperature for 8 minutes, and then centrifuging at a speed of 3000 rpm for 15 minutes to obtain an enzymatically hydrolyzed ginger root extract;

[0176] S1.5, dissolving phospholipids and cholesterol in 95% ethanol to form a phospholipid solution with a concentration of 1.0 g / mL; dissolving the enzymatically hydrolyzed ginger root extract in deionized water to form an aqueous phase solution;

[0177] S1.6, adding the phospholipid solution to the aqueous phase solution, stirring vigorously with a stirrer at a speed of 1200 rpm and a temperature of 50°C for 10 min to form a uniform primary emulsion;

[0178] S1.7. The primary emulsion was subjected to ultrasonic treatment at a power of 200 W for 5 min to obtain ginger root extract phospholipid nanoparticles with a particle size of 60 mm.

[0179] Embodiment 8: A process for preparing a heating paste, comprising the following steps:

[0180] S1. Weigh the following raw materials in parts by weight respectively: 60 parts by weight of water, 8 parts by weight of glycerol, 6 parts by weight of propylene glycol, 2 parts by weight of ginger root extract phospholipid nanoparticles, 3 parts by weight of cinnamon extract, 2 parts by weight of polyethylene glycol, 3 parts by weight of PEG-40 hydrogenated castor oil, 3 parts by weight of hydrogenated polyisobutene, 1 part by weight of carbomer, 0.8 parts by weight of triethanolamine, 0.8 parts by weight of phenoxyethanol, 1 part by weight of chitosan, 0.3 parts by weight of essence, 0.3 parts by weight of vanillyl butyl ether, 0.8 parts by weight of ethylhexylglycerol, and 0.8 parts by weight of pepper seed oil;

[0181] S2, mixing the cinnamon extract with PEG-40 hydrogenated castor oil, stirring with a magnetic stirrer, the stirring temperature is 45° C., the stirring speed is 1500 rpm, and the stirring time is 15 min to obtain a cinnamon extract emulsion with a concentration of 0.03 g / mL;

[0182] S3, mixing ginger root extract phospholipid nanoparticles with cinnamon extract emulsion, and preparing nanofibers by electrospinning, wherein the voltage of the electrospinning machine is set to 20 kV, the flow rate is set to 0.5 mL / h, and the distance from the spinneret to the receiver is set to 20 cm;

[0183] The nanofibers were collected on a receiver to form a nanofiber membrane, and then dried at a temperature of 50°C for 3 hours.

[0184] The dried nanofiber membrane was cut into small pieces and added into water, and then dispersed into a suspension using ultrasound. The power of the ultrasound was set at 500 W and the treatment time was set at 1 h.

[0185] Add polyethylene glycol to the suspension, and homogenize using a homogenizer at 45°C and 12000 rpm for 10 min to form a composite emulsion;

[0186] S4, mixing water, glycerin and propylene glycol, heating and stirring with a magnetic stirrer, the stirring temperature is 45°C, the stirring speed is 300 rpm, and the stirring time is 15 min; after stirring evenly, adding carbomer at 0.1 parts by weight per minute, stirring at a speed of 300 rpm for 40 min to allow the carbomer to swell completely;

[0187] S5, stirring hydrogenated polyisobutene, pepper seed oil, triethanolamine, phenoxyethanol, ethylhexylglycerin, chitosan, flavor and vanillyl butyl ether with a magnetic stirrer at 45° C. and 300 rpm for 20 min to obtain a mixed solution;

[0188] S6, adding the composite emulsion in S3 to S4, stirring with a magnetic stirrer at 40°C and 800 rpm for 20 min; then adding the mixed solution in S5, stirring continuously with a magnetic stirrer, the stirring temperature is 40°C, the stirring speed is 1200 rpm, and the stirring time is 20 min;

[0189] S7. Finally, use a homogenizer to homogenize 4 times at a pressure of 25 MPa to obtain a heating paste.

[0190] The ginger root extract phospholipid nanoparticles were prepared as follows:

[0191] S1.1. Weigh the following raw materials in parts by weight: 12 parts by weight of ginger root extract, 55 parts by weight of phosphate buffer solution, 1.44 parts by weight of papain, 8 parts by weight of phospholipids, 3 parts by weight of cholesterol, and 15 parts by weight of ethanol;

[0192] S1.2, dissolving the ginger root extract in phosphate buffer (pH 6.0), stirring with a magnetic stirrer at 200 rpm for 15 min at room temperature to obtain a ginger root extract solution with a concentration of 0.024 g / mL;

[0193] S1.3, the papain was added to the ginger root extract solution in a constant temperature oscillator, the constant temperature oscillator at a speed of 200rpm, the temperature was 55 ℃, the enzymatic reaction, the reaction time was 4h;

[0194] S1.4, heating the reaction system of S1.3 to 90°C, maintaining the temperature for 8 minutes, and then centrifuging at a speed of 3000 rpm for 15 minutes to obtain an enzymatically hydrolyzed ginger root extract;

[0195] S1.5, dissolving phospholipids and cholesterol in 95% ethanol to form a phospholipid solution with a concentration of 0.8 g / mL; dissolving the enzymatically hydrolyzed ginger root extract in deionized water to form an aqueous phase solution;

[0196] S1.6, adding the phospholipid solution to the aqueous phase solution, stirring vigorously with a stirrer at a speed of 1200 rpm and a temperature of 50°C for 10 min to form a uniform primary emulsion;

[0197] S1.7. The primary emulsion was subjected to ultrasonic treatment at a power of 200 W for 5 min to obtain ginger root extract phospholipid nanoparticles with a particle size of 60 mm.

[0198] Embodiment 9: A process for preparing a heating paste, comprising the following steps:

[0199] S1. Weigh the following raw materials in parts by weight respectively: 60 parts by weight of water, 8 parts by weight of glycerol, 6 parts by weight of propylene glycol, 3 parts by weight of ginger root extract phospholipid nanoparticles, 2 parts by weight of cinnamon extract, 2 parts by weight of polyethylene glycol, 3 parts by weight of PEG-40 hydrogenated castor oil, 3 parts by weight of hydrogenated polyisobutene, 1 part by weight of carbomer, 0.8 parts by weight of triethanolamine, 0.8 parts by weight of phenoxyethanol, 1 part by weight of chitosan, 0.3 parts by weight of essence, 0.3 parts by weight of vanillyl butyl ether, 0.8 parts by weight of ethylhexylglycerin, and 0.8 parts by weight of pepper seed oil;

[0200] S2, mixing the cinnamon extract with PEG-40 hydrogenated castor oil, stirring with a magnetic stirrer, the stirring temperature is 45° C., the stirring speed is 1500 rpm, and the stirring time is 15 min to obtain a cinnamon extract emulsion with a concentration of 0.02 g / mL;

[0201] S3, mixing ginger root extract phospholipid nanoparticles with cinnamon extract emulsion, and preparing nanofibers by electrospinning, wherein the voltage of the electrospinning machine is set to 20 kV, the flow rate is set to 0.5 mL / h, and the distance from the spinneret to the receiver is set to 20 cm;

[0202] The nanofibers were collected on a receiver to form a nanofiber membrane, and then dried at a temperature of 50°C for 3 hours.

[0203] The dried nanofiber membrane was cut into small pieces and added into water, and then dispersed into a suspension using ultrasound. The power of the ultrasound was set at 500 W and the treatment time was set at 1 h.

[0204] Add polyethylene glycol to the suspension, and homogenize using a homogenizer at 45°C and 12000 rpm for 10 min to form a composite emulsion;

[0205] S4, mixing water, glycerin and propylene glycol, heating and stirring with a magnetic stirrer, the stirring temperature is 45°C, the stirring speed is 300 rpm, and the stirring time is 15 min; after stirring evenly, adding carbomer at 0.1 parts by weight per minute, stirring at a speed of 300 rpm for 40 min to allow the carbomer to swell completely;

[0206] S5, stirring hydrogenated polyisobutene, pepper seed oil, triethanolamine, phenoxyethanol, ethylhexylglycerin, chitosan, flavor and vanillyl butyl ether with a magnetic stirrer at 45° C. and 300 rpm for 20 min to obtain a mixed solution;

[0207] S6, adding the composite emulsion in S3 to S4, stirring with a magnetic stirrer at 40°C and 800 rpm for 20 min; then adding the mixed solution in S5, stirring continuously with a magnetic stirrer, the stirring temperature is 40°C, the stirring speed is 1200 rpm, and the stirring time is 20 min;

[0208] S7. Finally, use a homogenizer to homogenize 4 times at a pressure of 25 MPa to obtain a heating paste.

[0209] The ginger root extract phospholipid nanoparticles were prepared as follows:

[0210] S1.1. Weigh the following raw materials in parts by weight: 12 parts by weight of ginger root extract, 55 parts by weight of phosphate buffer solution, 1.44 parts by weight of papain, 8 parts by weight of phospholipids, 3 parts by weight of cholesterol, and 15 parts by weight of ethanol;

[0211] S1.2, dissolving the ginger root extract in phosphate buffer (pH 6.0), stirring with a magnetic stirrer at 200 rpm for 15 min at room temperature to obtain a ginger root extract solution with a concentration of 0.024 g / mL;

[0212] S1.3, the papain was added to the ginger root extract solution in a constant temperature oscillator, the constant temperature oscillator at a speed of 200rpm, the temperature was 55 ℃, the enzymatic reaction, the reaction time was 4h;

[0213] S1.4, heating the reaction system of S1.3 to 90°C, maintaining the temperature for 8 minutes, and then centrifuging at a speed of 3000 rpm for 15 minutes to obtain an enzymatically hydrolyzed ginger root extract;

[0214] S1.5, dissolving phospholipids and cholesterol in 95% ethanol to form a phospholipid solution with a concentration of 0.8 g / mL; dissolving the enzymatically hydrolyzed ginger root extract in deionized water to form an aqueous phase solution;

[0215] S1.6, adding the phospholipid solution to the aqueous phase solution, stirring vigorously with a stirrer at a speed of 1200 rpm and a temperature of 50°C for 10 min to form a uniform primary emulsion;

[0216] S1.7. The primary emulsion was subjected to ultrasonic treatment at a power of 200 W for 5 min to obtain ginger root extract phospholipid nanoparticles with a particle size of 60 mm.

[0217] Embodiment 10: A process for preparing a heating paste, comprising the following steps:

[0218] S1. Weigh the following raw materials in parts by weight respectively: 55 parts by weight of water, 5 parts by weight of glycerol, 3 parts by weight of propylene glycol, 3 parts by weight of ginger root extract phospholipid nanoparticles, 3 parts by weight of cinnamon extract, 1 part by weight of polyethylene glycol, 2 parts by weight of PEG-40 hydrogenated castor oil, 2 parts by weight of hydrogenated polyisobutene, 0.5 parts by weight of carbomer, 0.5 parts by weight of triethanolamine, 0.5 parts by weight of phenoxyethanol, 0.5 parts by weight of chitosan, 0.1 parts by weight of essence, 0.1 parts by weight of vanillyl butyl ether, 0.5 parts by weight of ethylhexylglycerin, and 0.5 parts by weight of pepper seed oil;

[0219] S2, mixing the cinnamon extract with PEG-40 hydrogenated castor oil, stirring with a magnetic stirrer, the stirring temperature is 45° C., the stirring speed is 1500 rpm, and the stirring time is 15 min, to obtain a cinnamon extract emulsion with a concentration of 0.04 g / mL;

[0220] S3, mixing ginger root extract phospholipid nanoparticles with cinnamon extract emulsion, and preparing nanofibers by electrospinning, wherein the voltage of the electrospinning machine is set to 20 kV, the flow rate is set to 0.5 mL / h, and the distance from the spinneret to the receiver is set to 20 cm;

[0221] The nanofibers were collected on a receiver to form a nanofiber membrane, and then dried at a temperature of 50°C for 3 hours.

[0222] The dried nanofiber membrane was cut into small pieces and added into water, and then dispersed into a suspension using ultrasound. The power of the ultrasound was set at 500 W and the treatment time was set at 1 h.

[0223] Add polyethylene glycol to the suspension, and homogenize using a homogenizer at 45°C and 12000 rpm for 10 min to form a composite emulsion;

[0224] S4, mixing water, glycerin and propylene glycol, heating and stirring with a magnetic stirrer, the stirring temperature is 45°C, the stirring speed is 300 rpm, and the stirring time is 15 min; after stirring evenly, adding carbomer at 0.1 parts by weight per minute, stirring at a speed of 300 rpm for 40 min to allow the carbomer to swell completely;

[0225] S5, stirring hydrogenated polyisobutene, pepper seed oil, triethanolamine, phenoxyethanol, ethylhexylglycerin, chitosan, flavor and vanillyl butyl ether with a magnetic stirrer at 45° C. and 300 rpm for 20 min to obtain a mixed solution;

[0226] S6, adding the composite emulsion in S3 to S4, stirring with a magnetic stirrer at 40°C and 800 rpm for 20 min; then adding the mixed solution in S5, stirring continuously with a magnetic stirrer, the stirring temperature is 40°C, the stirring speed is 1200 rpm, and the stirring time is 20 min;

[0227] S7. Finally, use a homogenizer to homogenize 4 times at a pressure of 25 MPa to obtain a heating paste.

[0228] The ginger root extract phospholipid nanoparticles were prepared as follows:

[0229] S1.1. Weigh the following raw materials in parts by weight: 12 parts by weight of ginger root extract, 55 parts by weight of phosphate buffer solution, 1.44 parts by weight of papain, 8 parts by weight of phospholipids, 3 parts by weight of cholesterol, and 15 parts by weight of ethanol;

[0230] S1.2, dissolving the ginger root extract in phosphate buffer (pH 6.0), stirring with a magnetic stirrer at 200 rpm for 15 min at room temperature to obtain a ginger root extract solution with a concentration of 0.024 g / mL;

[0231] S1.3, the papain was added to the ginger root extract solution in a constant temperature oscillator, the constant temperature oscillator at a speed of 200rpm, the temperature was 55 ℃, the enzymatic reaction, the reaction time was 4h;

[0232] S1.4, heating the reaction system of S1.3 to 90°C, maintaining the temperature for 8 minutes, and then centrifuging at a speed of 3000 rpm for 15 minutes to obtain an enzymatically hydrolyzed ginger root extract;

[0233] S1.5, dissolving phospholipids and cholesterol in 95% ethanol to form a phospholipid solution with a concentration of 0.8 g / mL; dissolving the enzymatically hydrolyzed ginger root extract in deionized water to form an aqueous phase solution;

[0234] S1.6, adding the phospholipid solution to the aqueous phase solution, stirring vigorously with a stirrer at a speed of 1200 rpm and a temperature of 50°C for 10 min to form a uniform primary emulsion;

[0235] S1.7. The primary emulsion was subjected to ultrasonic treatment at a power of 200 W for 5 min to obtain ginger root extract phospholipid nanoparticles with a particle size of 60 mm. Comparative Example 1

[0236] The method of Example 2 was used without using ginger root extract phospholipid nanoparticles. Comparative Example 2

[0237] The method of Example 2 was used to remove phospholipids from the ginger root extract phospholipid nanoparticles. Comparative Example 3

[0238] The method of Example 2 is adopted to remove the cinnamon extract in the heating ointment.

[0239] The present invention prepares a fever-inducing ointment using ginger root extract phospholipid nanoparticles, wherein the performance test of the fever-inducing ointment is as follows:

[0240] Heating temperature: Apply an appropriate amount of heating cream evenly to the inside of the wrist or other sensitive but not fragile skin parts, avoiding direct contact with wounds or damaged skin. Before applying the heating cream, measure the skin temperature of the area as a baseline value. At regular intervals (such as every 5 minutes), use an infrared skin thermometer to measure the skin temperature of the application area and record it.

[0241] Duration: Apply an appropriate amount of heating cream evenly to the inside of the wrist or other sensitive but not fragile skin parts, avoiding direct contact with wounds or damaged skin. Before applying the heating cream, measure the skin temperature of the area as the baseline value. At regular intervals (such as every 5 minutes), use an infrared skin thermometer to measure the skin temperature of the application area and record it. Continue to record the temperature until the skin temperature of the application area returns to the baseline value or close to the baseline value. The time recorded is the duration of the heating cream.

[0242] According to the above standards, the heating pastes prepared in the above Examples 1-10 and Comparative Examples 1-3 were tested, and the obtained data are shown in Table 1:

[0243] Table 1 Performance data of the heating paste of Examples 1-10 and Comparative Examples 1-3

[0244]

[0245] It can be seen from Examples 1-4, Example 8, Example 7 and Comparative Example 1 that when the mass ratio of ginger root extract to protease gradually increases, the heating temperature and duration of the heating cream gradually increase, but when the mass ratio of ginger root extract to protease reaches a certain value, the heating temperature and duration of the heating cream significantly decrease. It can be seen that by adjusting the mass ratio of ginger root extract to protease, the heating temperature and duration of the heating cream can be regulated. As the ratio of protease increases, the heating temperature and duration of the heating cream are improved, but excessive increase may reduce the heating temperature and duration of the heating cream;

[0246] Specifically, the active ingredients in ginger root extract (such as gingerol, zingerone, etc.) are usually wrapped in the cell wall. Proteases can hydrolyze the protein components in the cell wall and destroy the cell wall structure, thereby promoting the release of active ingredients. More active ingredients are released, which can enhance the heating effect of the heating cream, allowing it to quickly reach the ideal heating temperature in a short time, and can also make the heating effect more uniform and reduce local overheating or overcooling.

[0247] During the protease hydrolysis process, large molecular proteins and polysaccharides will be broken down into small molecules, which are more easily absorbed by the skin, thereby improving the bioavailability of active ingredients (such as gingerol, zingiberone, etc.). Small molecular active ingredients can more easily penetrate the surface of the skin and enter the deep tissues, exerting better heating and therapeutic effects, so that the heating effect can penetrate deeper into the muscles and joints, providing a deeper sense of warmth.

[0248] It can be seen from Example 2 and Example 5 combined with Comparative Example 2 that when the phospholipids in the ginger root extract phospholipid nanoparticles are removed, the heating temperature and duration of the heating cream are significantly reduced;

[0249] Phospholipids themselves have a certain degree of thermal stability and can promote the generation of heat under certain conditions. Phospholipid molecules can form liposome structures, which help to retain and release heat. When phospholipids are removed from nanoparticles, this structural advantage is lost, resulting in a weakened heating effect. Ginger root extract after enzymatic hydrolysis can be combined with phospholipid nanocarriers to form stable nanoparticles, further protecting active ingredients (such as gingerol, zingerone, etc.) from the influence of the external environment, and can be better dispersed and stabilized, thereby improving their bioavailability.

[0250] And taking Example 2 as the best example, and combining Example 6, Example 9 and Comparative Example 3, it can be seen that when the cinnamon extract in the heating cream is removed, the heating temperature and duration of the heating cream are significantly reduced;

[0251] The active ingredients in cinnamon extract, especially cinnamaldehyde, cause vasodilation by activating receptors on vascular smooth muscle cells; this increases local blood flow, allowing more blood to flow to the skin surface, thereby increasing local temperature. The increased blood flow not only increases the temperature, but also accelerates the absorption and diffusion of other drug ingredients, enhancing the efficacy of the heating cream; in addition, the ingredients in cinnamon extract can increase the metabolic rate of local tissues, further enhancing the heating effect; after removing the cinnamon extract, the lack of effective vasodilators leads to a decrease in local blood flow, which directly affects the increase in local temperature and significantly weakens the heating effect. Due to the decrease in blood flow, the absorption and diffusion of other drug ingredients will also slow down, further reducing the overall effect of the heating cream.

[0252] Furthermore, ginger root contains ingredients such as gingerol, which can stimulate blood circulation and produce a sense of warmth; cinnamon is rich in compounds such as cinnamaldehyde, which also has the effect of promoting local blood circulation; when they are present in the heating cream in a specific form (such as phospholipid nanoparticles and emulsions), they can enhance the ability of active ingredients to pass through the skin barrier, thereby making the heating effect more obvious. The combination of the two produces an additive or complementary effect due to their physiological effects under different mechanisms, thereby enhancing the performance of the heating cream.

[0253] The above shows and describes the basic principles, main features and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited by the above embodiments. The above embodiments and descriptions are only preferred examples of the present invention and are not intended to limit the present invention. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, which fall within the scope of the present invention. The scope of protection of the present invention is defined by the attached claims and their equivalents.

Claims

1. A heating cream, characterized in that: The invention comprises the following raw materials: 55-65 parts by weight of water, 5-10 parts by weight of glycerin, 3-8 parts by weight of propylene glycol, 2-4 parts by weight of ginger root extract phospholipid nanoparticles, 2-4 parts by weight of cinnamon extract, 1-3 parts by weight of polyethylene glycol, 2-5 parts by weight of PEG-40 hydrogenated castor oil, 2-5 parts by weight of hydrogenated polyisobutene, 0.5-1.5 parts by weight of carbomer, 0.5-1 parts by weight of triethanolamine, 0.5-1 parts by weight of phenoxyethanol, 0.5-1 parts by weight of chitosan, 0.1-0.5 parts by weight of essence, 0.1-0.5 parts by weight of vanillyl butyl ether, 0.5-1 parts by weight of ethylhexylglycerol and 0.5-1 parts by weight of pepper seed oil; Among them, ginger root extract phospholipid nanoparticles are prepared by enzymatically hydrolyzing ginger root extract with protease and then loading it with phospholipids at nanoscale; The protease is any one of papain, bromelain or trypsin; The preparation method of the ginger root extract phospholipid nanoparticles is as follows: S1.

1. Weigh the following raw materials in parts by weight respectively: 10-15 parts by weight of ginger root extract, 50-60 parts by weight of phosphate buffer solution, 0.5-2.5 parts by weight of protease, 5-10 parts by weight of phospholipids, 2-5 parts by weight of cholesterol, and 10-20 parts by weight of ethanol; S1.2, dissolving the ginger root extract in a phosphate buffer solution with a pH of 5.0-7.0, stirring with a magnetic stirrer at a speed of 100-200 rpm for 15-30 min at room temperature to obtain a ginger root extract solution with a concentration of 0.02-0.03 g / mL; S1.3, adding protease to the ginger root extract solution and placing it in a constant temperature oscillator for enzymatic hydrolysis reaction; S1.4, heating the reaction system in S1.3 to 85-90°C, maintaining the temperature for 5-10 minutes, and then centrifuging to obtain an enzymatically hydrolyzed ginger root extract; S1.5, dissolving phospholipids and cholesterol in 95-100% ethanol to form a phospholipid solution with a concentration of 0.5-1 g / mL; dissolving the enzymatically hydrolyzed ginger root extract in deionized water to form an aqueous phase solution; S1.6, adding the phospholipid solution to the aqueous phase solution, and vigorously stirring using a magnetic stirrer to form a uniform primary emulsion; S1.

7. Ultrasonic treatment is performed on the primary emulsion to obtain ginger root extract phospholipid nanoparticles with a particle size of 20-80 mm.

2. The heat-generating paste according to claim 1, characterized in that: In S1.3, the speed of the thermostatic oscillator is set to 200-400 rpm, the temperature is set to 55-65° C., and the reaction time is 2-4 h.

3. The heat-generating paste according to claim 1, characterized in that: In S1.4, the centrifugal treatment is performed by a centrifuge, and the centrifugal speed of the centrifuge is set to 3000-5000 rpm, and the centrifugal time is 15-20 min.

4. The heat-generating paste according to claim 1, characterized in that: In S1.6, the stirring speed of the magnetic stirrer is 1000-2000 rpm, the stirring temperature is 40-60° C., and the stirring time is 5-10 min.

5. The heat-generating paste according to claim 1, characterized in that: In the S1.7, the ultrasonic treatment time is 5-10 minutes, and the ultrasonic power is set to 200-300W.

6. A process for preparing a heating paste, used for preparing the heating paste according to any one of claims 1 to 5, characterized in that: The preparation process is as follows; S1. Weigh the following raw materials in parts by weight respectively: 55-65 parts by weight of water, 5-10 parts by weight of glycerol, 3-8 parts by weight of propylene glycol, 2-4 parts by weight of ginger root extract phospholipid nanoparticles, 2-4 parts by weight of cinnamon extract, 1-3 parts by weight of polyethylene glycol, 2-5 parts by weight of PEG-40 hydrogenated castor oil, 2-5 parts by weight of hydrogenated polyisobutene, 0.5-1.5 parts by weight of carbomer, 0.5-1 parts by weight of triethanolamine, 0.5-1 parts by weight of phenoxyethanol, 0.5-1 parts by weight of chitosan, 0.1-0.5 parts by weight of essence, 0.1-0.5 parts by weight of vanillyl butyl ether, 0.5-1 parts by weight of ethylhexylglycerol, and 0.5-1 parts by weight of pepper seed oil; S2, mixing the cinnamon extract and PEG-40 hydrogenated castor oil and stirring them evenly to obtain a cinnamon extract emulsion with a concentration of 0.02-0.04 g / mL; S3, mixing ginger root extract phospholipid nanoparticles with cinnamon extract emulsion, and preparing nanofibers by electrospinning, wherein the voltage of the electrospinning machine is set to 10-30 kV, the flow rate is set to 0.1-1 mL / h, and the distance from the spinneret to the receiver is set to 10-30 cm; The nanofibers are collected on a receiver to form a nanofiber membrane, and then dried. The drying temperature is set to 30-60°C and the drying time is 1-3h. The dried nanofiber membrane was cut into small pieces and added into water, and then dispersed into a suspension using ultrasound. The power of the ultrasound was set at 100-1000W and the treatment time was set at 0.5-1h. Adding polyethylene glycol to the suspension, and homogenizing using a homogenizer at 40-50° C. and a speed of 10000-15000 rpm for 10-15 minutes to form a composite emulsion; S4, mixing water, glycerin and propylene glycol, heating and stirring with a magnetic stirrer, and after stirring evenly, adding carbomer at 0.1-0.2 parts by weight per minute, stirring at a speed of 200-400 rpm for 30-60 minutes to allow the carbomer to swell completely; S5, stirring hydrogenated polyisobutene, pepper seed oil, triethanolamine, phenoxyethanol, ethylhexylglycerin, chitosan, flavor and vanillyl butyl ether with a magnetic stirrer at 40-50° C. and at a speed of 200-300 rpm for 15-30 min to obtain a mixed solution; S6, adding the composite emulsion in S3 to S4, stirring with a magnetic stirrer at 40-50°C and 600-800 rpm for 15-30 min; then adding the mixed solution in S5 and continuing stirring; S7. Finally, use a homogenizer to homogenize 3-5 times at a pressure of 20-50 MPa to obtain a heating paste.

7. The preparation process of the heating paste according to claim 6, characterized in that: In S2, the stirring temperature of the magnetic stirrer is 40-50°C, the stirring speed is 1000-2000rpm, and the stirring time is 10-15min.

8. The preparation process of the heating paste according to claim 6, characterized in that: In S4, the stirring temperature of the magnetic stirrer is 40-50°C, the stirring speed is 200-300 rpm, and the stirring time is 10-15 min.

9. The preparation process of the heating paste according to claim 6, characterized in that: In S6, stirring is continued with a magnetic stirrer, the stirring temperature is 40-50° C., the stirring speed is 1000-1500 rpm, and the stirring time is 10-20 min.

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