Depression-resolving and nerve-calming formula for treating insomnia and relieving anxiety and preparation method thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicine compounds, and provides a depression-resolving and nerve-calming formula for treating insomnia and relieving anxiety and a preparation method thereof, the depression-resolving and nerve-calming formula comprises the following raw materials: 10-30 parts of radix curcumae, 8-24 parts of radix asparagi, 5-15 parts of flos albiziae, 2-6 parts of cortex cinnamomi, 1-3 parts of semen ziziphi spinosae, 1-3 parts of magnetite and 1-3 parts of amber; the depression-resolving and nerve-soothing compound prescription can effectively improve the physical conditions such as eating, hair color and weight of rats with insomnia; the sleep latency period of rats with insomnia is shortened, the sleep duration is prolonged, and the in-vivo 5-HT level is adjusted, so that an exact treatment effect on insomnia is achieved; for a depression rat model, the total activity distance of depression rats can be effectively increased, and the autonomous swimming time and the tail suspension struggling time are prolonged.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine compound prescriptions, and in particular is a prescription for relieving depression and calming the nerves for treating insomnia and relieving anxiety, and a preparation method thereof. Background Art

[0002] Insomnia refers to a type of disease in which the patient is still dissatisfied with the quality and duration of sleep despite having suitable sleeping conditions, and is accompanied by daytime social dysfunction. With the increasing social pressure, insomnia has become a common and frequently occurring clinical disease. Insomnia can increase the risk of developing Alzheimer's disease, hypertension, depression, etc. Western medicine mainly uses benzodiazepines and non-benzodiazepines for treatment, which have the advantages of rapid onset and short half-life, but are often accompanied by adverse reactions such as headache, dizziness, abdominal pain, diarrhea, and drowsiness, and long-term use can lead to addiction, drug resistance, and dependence.

[0003] Depressive disorder is one of the most common mental disorders, which seriously endangers human health. According to the WHO Global Burden of Disease study, depressive disorder accounts for 10% of disability caused by non-infectious diseases. The core symptoms are low mood, lack of interest and loss of pleasure. Traditional Chinese medicine believes that depression is a disease caused by emotional distress and mental stimulation, which leads to worry and qi stagnation, and qi stagnation. Over time, it turns into heat and fire, disturbing the mind. Insomnia aggravates depression, and conversely, depressed patients are often accompanied by insomnia symptoms. The two form a vicious cycle. Therefore, it is urgent to develop sedatives with few side effects and significant therapeutic effects.

[0004] Therefore, those skilled in the art have proposed a prescription for relieving depression and calming the mind for treating insomnia and relieving anxiety and a preparation method thereof to solve the problems raised by the background technology. Summary of the invention

[0005] In order to solve the above technical problems, the present invention provides a depression-relieving and mind-calming prescription for treating insomnia and relieving anxiety and a preparation method thereof, so as to solve the problems existing in the prior art.

[0006] A prescription for relieving depression and calming the mind for treating insomnia and alleviating anxiety comprises the following raw materials by weight: 10-30 parts of turmeric, 8-24 parts of asparagus cochinchinensis, 5-15 parts of julibrissin flowers, 2-6 parts of cinnamon bark, 1-3 parts of spiny jujube seeds, 1-3 parts of magnetite and 1-3 parts of amber.

[0007] Preferably, the above-mentioned Chinese herbal compound composition for treating insomnia is made of the following raw materials in parts by weight: 20 parts of Curcuma aromatica, 16 parts of Asparagus cochinchinensis, 10 parts of Albizzia julibrissin, 4 parts of Cinnamon bark, 2 parts of Ziziphus jujuba seeds, 2 parts of Magnetite, and 2 parts of Amber.

[0008] A method for preparing a prescription for treating insomnia and relieving anxiety using the above formula:

[0009] Step 1, taking Curcuma aromatica, Asparagus cochinchinensis, Albizzia julibrissin, Cinnamon bark, Semen jujuba, Magnetite, and Amber according to weight proportions;

[0010] Step 2: add 10 to 20 times the weight of the medicinal material in water and boil or reflux extract with ethanol for 1 to 3 times, each time for 0.5 to 2 hours;

[0011] Step 3: Combine the extracts and concentrate them to obtain an extract, which is the prescription for relieving depression and calming the mind.

[0012] Preferably, the decoction or ethanol reflux extraction in step 2 is specifically as follows: first, decoct over high heat until boiling, then keep it slightly boiling over low heat for 1.5-2.0 hours, and pour it out through gauze to filter to obtain the first filtrate; add water to the residue, then decoct over high heat until boiling, then keep it slightly boiling over low heat for 25-35 minutes, and pour it out through gauze to filter to obtain the second filtrate.

[0013] Compared with the prior art, the present invention has the following beneficial effects:

[0014] The invention provides a depression-relieving and tranquilizing prescription and a preparation method thereof. The depression-relieving and tranquilizing prescription compound of the invention can effectively improve the physical conditions of insomnia rats such as eating, coat color, and body weight; shorten the sleep latency of insomnia rats, prolong the sleep duration, and regulate the 5-HT level in the body, thereby playing a definite therapeutic effect on insomnia; and for a depression rat model, can effectively increase the total activity distance of the depression rats, prolong the autonomous swimming time and the tail suspension struggling time; therefore, the depression-relieving and tranquilizing prescription of the invention can relieve anxiety and treat insomnia, and the medication is safe and reliable. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 It is a comparative schematic diagram of the 5-HT content in the hypothalamus of each group of rats in the present invention. DETAILED DESCRIPTION

[0016] The following embodiments of the present invention are described in further detail in conjunction with the accompanying drawings and examples. The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention.

[0017] The invention provides a prescription for relieving depression and calming the mind for treating insomnia and alleviating anxiety. The prescription comprises the following raw materials by weight: 10-30 parts of turmeric, 8-24 parts of asparagus cochinchinensis, 5-15 parts of julibrissin flowers, 2-6 parts of cinnamon bark, 1-3 parts of spiny jujube seeds, 1-3 parts of magnetite and 1-3 parts of amber.

[0018] Embodiment 1: A prescription for treating insomnia and relieving anxiety, comprising the following raw materials by weight: 10 parts of Curcuma aromatica, 8 parts of Asparagus cochinchinensis, 5 parts of Albizzia julibrissin, 2 parts of Cinnamon bark, 1 part of Ziziphus jujuba seeds, 1 part of Magnetite, and 1 part of Amber.

[0019] A method for preparing a prescription for treating insomnia and relieving anxiety using the above formula:

[0020] Step 1, taking Curcuma aromatica, Asparagus cochinchinensis, Albizzia julibrissin, Cinnamon bark, Semen jujuba, Magnetite, and Amber according to weight proportions;

[0021] Step 2, adding 10 to 20 times the weight of the medicinal material in water and decocting or ethanol reflux extraction for 1 to 3 times, each time for 0.5 to 2 hours; the decoction or ethanol reflux extraction in the step 2 is specifically as follows: first decocting to boiling over high heat, then keeping it slightly boiling for 1.5-2.0 hours over low heat, pouring it out through gauze to filter to obtain the first filtrate; adding water to the residue, decocting again over high heat to boiling, keeping it slightly boiling for 25-35 minutes over low heat, pouring it out through gauze to filter to obtain the second filtrate;

[0022] Step 3: Combine the extracts and concentrate them to obtain an extract, which is the prescription for relieving depression and calming the mind.

[0023] Embodiment 2: This embodiment is basically the same as the previous embodiment, except that, a prescription for relieving depression and calming the mind for treating insomnia and relieving anxiety comprises the following raw materials by weight: 20 parts of Curcuma aromatica, 16 parts of Asparagus cochinchinensis, 10 parts of Albizzia julibrissin, 4 parts of Cinnamon bark, 2 parts of Ziziphus jujuba seeds, 2 parts of Magnetite, and 2 parts of Amber.

[0024] Example 3: This example is basically the same as the previous example, except that a prescription for treating insomnia and relieving anxiety, comprising the following raw materials by weight: 30 parts of Curcuma aromatica, 24 parts of Asparagus cochinchinensis, 15 parts of Albizzia julibrissin, 6 parts of Cinnamon bark, 3 parts of Ziziphus jujuba seeds, 3 parts of Magnetite, and 3 parts of Amber.

[0025] From the above, it can be seen that this method obtains the following beneficial effects:

[0026] 1) The Jieyu Anshen formula of the present invention can effectively improve the physical conditions of insomnia rats such as eating, coat color, and body weight; shorten the sleep latency of insomnia rats, prolong the sleep duration, and regulate the 5-HT level in the body, thereby playing a definite therapeutic effect on insomnia.

[0027] 2) For the depression rat model, the present invention can effectively increase the total distance of the depressed rats' activities, prolong the autonomous swimming time and the tail suspension struggling time, showing a significant anti-depression effect.

[0028] 3) The prescription for relieving depression and calming the mind of the present invention is safe and reliable, and achieves the effect of calming the mind and calming the mind through a natural Chinese herbal medicine formula, avoiding the common adverse reactions and dependence problems in the treatment of insomnia and depression with Western medicine.

[0029] 4) The preparation method of the present invention is simple and easy to implement, suitable for industrial production, and conducive to promotion and application.

[0030] Furthermore, the beneficial effects of Example 1 to Example 3 are compared to obtain the following table:

[0031] Example Improve insomnia effect Anxiety relief effect Embodiment 1 Lower Lower Embodiment 2 Higher Higher Embodiment 3 Medium to high Medium to high

[0032] It can be seen from the above table that the effect of the second embodiment is the optimal solution of the present embodiment.

[0033] The embodiments of the present invention are further described in detail below with reference to the accompanying drawings and tables.

[0034] As shown in Table 1, compared with the blank group, the immobility time of the rats in the model group was significantly reduced; compared with the model group, the immobility time of the rats in each drug-treated group was significantly increased, indicating that the Jieyu Anshen recipe has a sedative and hypnotic effect.

[0035] Table 1. Comparison of open field changes in rats in each group ( n=10)

[0036]

[0037] Note: Compared with the blank control group, ## P<0.01; compared with the model group, ** P<0.01.

[0038] After drug administration, the sleep latency and sleep duration of the five groups of rats were compared, and the differences were statistically significant after analysis of variance (P<0.05); further pairwise comparison showed that the sleep latency of the rats in the model group was longer than that in the blank group (P<0.05), and the sleep duration was shorter than that in the blank group (P<0.05); the sleep latency of the rats in the Jieyu Anshen Fang group and the diazepam group was shorter than that in the model group, and the sleep duration was longer than that in the model group.

[0039] Table 2. Comparison of sleep latency and duration in rats of each group ( n=10)

[0040]

[0041] Note: Compared with the blank control group, # P<0.05, ## P<0.01; compared with the model group, * P<0.05, ** P<0.01.

[0042] The comparison of 5-HT content in the hypothalamus of rats in the blank group, model group, diazepam group and Jieyu Anshen group was statistically significant (P<0.05) after variance analysis. Further pairwise comparison showed that the 5-HT content in the hypothalamus of rats in the model group was lower than that in the blank group; the 5-HT content in the hypothalamus of rats in the diazepam group and Jieyu Anshen group was higher than that in the model group. Figure 1 ;

[0043] Figure 1 Comparison of 5-HT content in the hypothalamus of rats in each group; compared with the blank control group, ###P<0.001; compared with the model group, *** P<0.001.

[0044] The body weight of depression model rats was significantly lower than that of the blank group. After 21 days of administration, the Jieyu Anshen recipe significantly increased the body weight of rats.

[0045] Table 3. Body weight measurement results of rats in each group ( n=10)

[0046]

[0047]

[0048] Note: Compared with the blank control group, # P<0.05; compared with the model group, * P<0.05, ** P<0.01.

[0049] As shown in Tables 4, 5 and 6, before the experiment (day 0), there were no significant differences in the immobility time in the forced swim test (FST), the center residence time in the open field test (OFT) and the tail suspension (TST) of the rats (P>0.05); on the 7th day of the experiment, the immobility time of the FST and TST of the rats in the model group was significantly prolonged compared with the control group, and the center residence time of the OFT was reduced (P<0.01); compared with the model group, the immobility time of the FST and TST of the rats in the Jieyu Anshen prescription group and the fluoxetine group was shortened, and the center residence time of the OFT was increased, among which the high-dose Jieyu Anshen prescription group had a more significant effect on improving the depressive behavior of the rats (P<0.01).

[0050] Table 4. Comparison of open field changes in rats in each group ( n=10)

[0051]

[0052] Note: Compared with the blank control group, ## P<0.01; compared with the model group, ** P<0.01.

[0053] Table 5. Comparison of immobility time in the tail suspension test in rats of each group ( n=10)

[0054]

[0055]

[0056] Note: Compared with the blank control group, ## P<0.01; compared with the model group, ** P<0.01.

[0057] Table 6. Comparison of immobility time in the forced swimming test among rats in each group ( n=10)

[0058]

[0059] Note: Compared with the blank control group, ## P<0.01; compared with the model group, ** P<0.01.

[0060] The warm turmeric in the prescription is cold in nature and pungent and bitter in taste. It enters the liver, gallbladder, zinc and lung meridians. It has the effects of promoting blood circulation and relieving pain, promoting qi and relieving depression, clearing the heart and cooling blood, and promoting bile and relieving jaundice. It can not only promote blood circulation, remove blood stasis and relieve pain, but also relieve liver qi and relieve depression. The warm turmeric is pungent, dispersing, bitter and cold in nature, and can clear the heart, relieve depression and open the mind. "Ben Cao Meng Quan" records: "Wen turmeric is light and upward in nature, and has a special effect in treating depression." "Yao Long Xiao Pin" records: "Wen turmeric opens the depression of the heart and liver, and treats insomnia and pain." Therefore, this prescription uses warm turmeric as the main medicine.

[0061] Asparagus cochinchinensis is cold in nature and sweet and bitter in taste. It enters the lung and kidney meridians. It has the effects of nourishing yin and moistening dryness, clearing the lungs and producing body fluids. The "Compendium of Materia Medica" records: "Asparagus cochinchinensis nourishes the upper source of water and connects to the kidneys, and treats cough, asthma, insomnia and all other symptoms of yin deficiency. This product can nourish kidney yin and reduce virtual fire."

[0062] The flower of Albizzia is warm in nature and bitter and pungent in taste. It enters the heart and sweet meridians. It has the effect of relieving depression and calming the mind. The "Chinese Materia Medica" records: "The flower of Albizzia relieves depression and calms the mind, regulates qi and stimulates appetite. It is used to treat depression, insomnia, chest tightness and poor appetite." It is good at relieving liver depression, soothing the heart and calming the mind. It is suitable for emotional frustration, anger and depression caused by restlessness, irritability, depression and insomnia.

[0063] Cinnamon is hot in nature and pungent and sweet in taste. It enters the kidney, spleen, heart and liver meridians. It has the effects of replenishing fire and yang, dispelling cold and relieving pain, warming the meridians, and guiding fire back to the origin. "Compendium of Materia Medica" records: "Cinnamon replenishes the deficiency of the life gate fire, guides the rootless fire to descend and return to the origin, and treats chronic cold, insomnia and dreaminess."

[0064] The Chinese date seed is mild in nature, sweet and sour in taste. It enters the liver, gallbladder and heart meridians. It has the effects of nourishing the heart and liver, calming the mind and nerves, astringing sweat and promoting body fluid. "Compendium of Materia Medica" records: "Chinese date seed enters the liver to store the soul and calm the mind, and is used to treat timidity and insomnia."

[0065] This product can nourish the heart yin, benefit the liver blood and calm the mind and soothe the nerves. It is an important medicine for nourishing the heart and soothing the nerves.

[0066] Magnet is cold and salty. It enters the heart, liver and kidney meridians. It has the effects of calming the nerves, calming the liver and suppressing yang, improving hearing and eyesight, and relieving asthma. "Compendium of Materia Medica" records: "Magnet can calm and nourish the true yin, nourish the kidney and benefit the essence, clear the ears and improve eyesight, and treat weakness, epilepsy and insomnia." This product is heavy and sinking, enters the heart meridian, and can calm the nerves and calm the nerves. It can clear the fire of the heart and liver, protect the true yin, calm the floating yang, and stabilize the mind.

[0067] Amber is mild in nature and sweet in taste. It enters the heart, liver and bladder meridians. It has the effects of calming the nerves, promoting blood circulation and removing blood stasis, and promoting diuresis and relieving stranguria. This product is heavy in quality and is good at calming the nerves and treating anxiety, palpitations, insomnia, forgetfulness and other symptoms.

[0068] The whole formula can calm the mind, relieve liver depression, and absorb kidney qi. It harmonizes water and fire, clears and replenishes, and takes into account both the symptoms and the root causes. It can calm the nerves and relieve depression, nourish blood and relieve restlessness, so that the mind can be calmed and sleep can be peaceful. The compound formula of Jieyu Anshen can effectively improve the physical conditions of insomnia and depression rats, such as eating, coat color, and weight; shorten the sleep latency of insomnia rats, prolong the sleep duration, and regulate the level of 5-HT in the body, thereby playing a definite therapeutic role on insomnia. For the depressed rat model, it can effectively increase the center residence time of depressed rats, prolong the autonomous swimming time and the tail suspension struggle time.

[0069] Application Example 1: Protective effect of Jieyu Anshen prescription on insomnia rats

[0070] 1) Preparation of Jieyu Anshen prescription: take 200g of Wenyu Jin, 160g of Asparagus cochinchinensis, 100g of Albizzia julibrissin, 40g of Cinnamon bark, 20g of Ziziphus jujuba seeds, 20g of Magnetite, and 20g of Amber, add 10 times the amount of water and soak overnight, take out the next day, let stand at room temperature for 1.5-2.5h, first decocted, boil over high heat first, keep it slightly boiling over low heat for 1.5-2.0h, pour it out through gauze and filter to obtain the first filtrate; add water to the residue, boil over high heat until boiling, keep it slightly boiling over low heat for 25-35min, pour it out through gauze and filter to obtain the second filtrate; combine the two filtrates, use a rotary evaporator, and concentrate under reduced pressure at 60°C to an extract state to obtain the Jieyu Anshen prescription.

[0071] 2) Preparation of insomnia model: The 4-chlorophenylalanine (DL-4-chlorophenylalanine, PCPA) insomnia model is the most commonly used pharmacological model of inducing sleep disorders to evaluate the sedative and hypnotic effects of drugs. Forty SD rats were intraperitoneally injected with PCPA solution (400 mg / kg) between 8:00 and 9:30 every day for 4 consecutive days. Another 10 rats were taken as the control group. Blood was collected from the eye sockets on the third day of modeling, and 6 rats were randomly selected from each group. The blood samples were kept at 4°C for 30 min and centrifuged at 3500 r / min for 10 min to obtain serum samples. The 5-HT levels in the serum of normal rats and rats after modeling were determined according to the instructions of the ELISA kit. The 5-HT level in the serum of the model rats was significantly lower than that of the normal rats (P < 0.001), indicating that the PCPA rat insomnia model was successfully prepared.

[0072] 3) Grouping and drug administration After modeling, the rats were randomly divided into a blank group, a model group, a positive drug diazepam (2 mg / kg) group, and a low-dose and high-dose (5, 10 g / kg) Jieyu Anshen recipe group, with 10 rats in each group. Each drug group was administered with the corresponding drug (20 mL / kg) at 8:00-9:00 every day, and the blank group and the model group were intragastrically administered with an equal volume of normal saline, once a day, for 7 consecutive days.

[0073] 4) Sleep latency and sleep duration in the sodium pentobarbital synergistic sleep experiment: One hour after the end of drug administration on the 7th day of the experiment, rats were intraperitoneally injected with sodium pentobarbital solution at a concentration of 40 mg / kg, and the sleep latency and sleep duration were recorded based on whether the righting reflex disappeared for more than 30 seconds.

[0074] 5) Open field test: The open field test was conducted on the third day after drug administration. The rats were placed in the central area for testing 30 minutes after drug administration. The test lasted for 6 minutes. The first 1 minute was the adaptation period, and the immobility time of the rats was recorded within 5 minutes.

[0075] 6) Rat sampling: serum samples were collected from rats in each group, and the 5-HT level in the serum of rats in each group was determined according to the instructions of the ELISA kit.

[0076] Application Example 2: Protective Effect of Jieyu Anshen Recipe on Depressed Rats

[0077] 1) Preparation of Jieyu Anshen prescription: take 200g of Wenyu Jin, 160g of Asparagus cochinchinensis, 100g of Albizzia julibrissin, 40g of Cinnamon bark, 20g of Ziziphus jujuba seeds, 20g of Magnetite, and 20g of Amber, add 10 times the amount of water and soak overnight, take out the next day, let stand at room temperature for 1.5-2.5h, first decocted, boil over high heat first, keep it slightly boiling over low heat for 1.5-2.0h, pour it out through gauze and filter to obtain the first filtrate; add water to the residue, boil over high heat until boiling, keep it slightly boiling over low heat for 25-35min, pour it out through gauze and filter to obtain the second filtrate; combine the two filtrates, use a rotary evaporator, and concentrate under reduced pressure at 60°C to an extract state to obtain the Jieyu Anshen prescription.

[0078] 2) Preparation of depression model: The rat depression model was established by chronic unpredictable mild stress (CUMS) stimulation combined with solitary housing. In addition to the normal feeding of 10 rats in the normal group, 30 rats in each group were given the following 7 different stimulations every day: electric shock to the sole of the foot for 1 minute, swimming in 4℃ ice water for 5 minutes, tail suspension for 3 minutes, tail clamping for 1 minute, fasting for 24 hours, water deprivation for 24 hours, and light exposure at night for 12 hours (each stimulation was applied once a day during the stress period, and each type was randomly applied 4 times to make it impossible to predict the type and time of the next stress). This lasted for 6 weeks. Each rat was placed in a separate cage and covered with an opaque baffle to establish a solitary housing environment. After the preparation of the depression model similar to that of humans was completed, except for the normal group, the remaining 40 rats were divided into a model group, a Jieyu Anshen recipe low-dose and high-dose (5, 10 g / kg) group, and a positive drug fluoxetine hydrochloride group by random number table method according to body weight, with 10 rats in each group, and Jieyu Anshen recipe (5 g / kg), Jieyu Anshen recipe (10 g / kg), and fluoxetine hydrochloride solution (3.17 mg / kg) were given by gavage to the corresponding groups respectively; the gavage experiment was conducted once a day for 22 days, and then the open field test, tail suspension test, forced swimming test and other animal behavior research experiments were used to observe and evaluate the rats in each group.

[0079] 3) Open field test: The open field test was conducted on the third day after drug administration. The rats were placed in the central area for testing 30 minutes after drug administration. The test lasted for 6 minutes. The first 1 minute was the adaptation period, and the immobility time of the rats was recorded within 5 minutes.

[0080] 4) Forced swimming test: Add water (temperature (20±2)℃) to an uncovered transparent glass bucket with a water depth of about 30cm. Place each experimental rat independently, stably and as upright as possible into the water. Record the rat's autonomous swimming time within 5 minutes using a camera and behavioral analysis software. Use partitions to separate the glass buckets. After each experimental rat completes the experiment, change the water and wipe it dry.

[0081] 5) Tail suspension test: Isolate the rats with polystyrene foam partitions, wrap medical viscose tape around the end of the rat's tail about 1 / 3 and fix it on the tail suspension instrument so that it is hanging upside down. Use the tail suspension instrument and camera to observe and record the rat's struggling time within 5 minutes.

[0082] The embodiments of the present invention are provided for the purpose of illustration and description. Although the embodiments of the present invention have been shown and described above, it can be understood that the above embodiments are exemplary and cannot be understood as limitations of the present invention. Ordinary technicians in this field can change, modify, replace and modify the above embodiments within the scope of the present invention.

Claims

1. A prescription for treating insomnia and relieving anxiety, characterized by: The invention comprises the following raw materials: 10-30 parts of turmeric, 8-24 parts of asparagus cochinchinensis, 5-15 parts of julibrissin flowers, 2-6 parts of cinnamon bark, 1-3 parts of spiny jujube seeds, 1-3 parts of magnetite and 1-3 parts of amber.

2. A prescription for treating insomnia and relieving anxiety as claimed in claim 1, characterized in that: The preferred weight proportions are: 20 parts of Curcuma aromatica, 16 parts of Asparagus cochinchinensis, 10 parts of Flos Albiziae, 4 parts of Cinnamon bark, 2 parts of Semen Ziziphi Spinosae, 2 parts of Magnetite, and 2 parts of Amber.

3. A method for preparing a prescription for treating insomnia and relieving anxiety according to any one of claims 1 or 2, characterized in that: include: S1. Take Curcuma aromatica, Asparagus cochinchinensis, Albizzia julibrissin, Cinnamon bark, Semen jujuba, Magnetite and Amber by weight; S2, add 10 to 20 times the weight of the medicinal material in water and boil or reflux extract with ethanol for 1 to 3 times, each time for 0.5 to 2 hours; S3. Combine the extracts and concentrate to obtain an extract.

4. A method for preparing a prescription for treating insomnia and relieving anxiety as claimed in claim 3, characterized in that: The decoction or ethanol reflux extraction in step S2 is specifically as follows: firstly decoct to boiling over high heat, then keep it slightly boiling over low heat for 1.5-2.0 hours, and then pour it out through gauze to filter to obtain the first filtrate; add water to the residue, then decoct to boiling over high heat, then keep it slightly boiling over low heat for 25-35 minutes, and then pour it out through gauze to filter to obtain the second filtrate.

5. Use of the Jieyu Anshen prescription for treating insomnia and relieving anxiety as claimed in any one of claims 1 or 2 in the preparation of a drug for treating insomnia or relieving anxiety.

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