Traditional Chinese veterinary medicine composition for preventing and treating respiratory diseases of newborn calves in northern cold regions

Abstract

The invention discloses a traditional Chinese veterinary medicine composition for preventing and treating respiratory diseases of newborn calves in northern cold regions, and belongs to the technical field of traditional Chinese veterinary medicines. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 16-24 parts of cassia twig, 16-24 parts of raw radix paeoniae alba, 8-12 parts of honeysuckle, 8-12 parts of dandelion, 8-12 parts of burdock, 8-12 parts of divaricate saposhnikovia root, 3-7 parts of honey and 3-7 parts of liquorice. The traditional Chinese veterinary medicine composition prepared in the embodiment 1 is used for feeding newborn calves to prevent respiratory diseases, and the morbidity can be reduced by 40%. When the traditional Chinese veterinary medicine composition is used for treating respiratory diseases of newborn calves, compared with a treatment group independently using ceftiofur sodium, the cure rate is improved by 13.6%, and the cure time is shortened by 36.24 h.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese veterinary medicines, in particular to a traditional Chinese veterinary medicine composition for preventing and treating respiratory diseases of newborn calves in northern cold regions. Background Art

[0002] Calf respiratory disease (BRD) is one of the common diseases in animal husbandry. It not only increases the culling rate of calves, affects the daily weight gain of calves, causes slow growth, and increases breeding costs, but also affects the growth of the rearing period and prolongs the time it takes for beef cattle to be put on the market.

[0003] The biological characteristics of cattle make them more inclined to conceal their own symptoms. In the wild, calves will conceal the external manifestations of the disease to avoid attracting the attention of predators. This instinct is still transmitted to existing cattle herds, so many breeders find that the calves are sick when the disease is already very serious. When clinical symptoms appear, it often has caused varying degrees of lung damage. In addition, respiratory diseases are highly contagious. Subclinically infected animals can spread to more susceptible animals before they are discovered, causing large-scale outbreaks of the disease. Therefore, it is urgent to provide a solution that can prevent and treat respiratory diseases in newborn calves. Summary of the invention

[0004] The purpose of the present invention is to provide a Chinese veterinary medicine composition for preventing and treating respiratory diseases in newborn calves in cold northern regions to solve the problems of the above-mentioned prior art. The northern region is cold and dry, and respiratory diseases are prevalent. In particular, newborn calves have weak lung qi and their functions of spreading and descending have not yet been fully established, making them the most susceptible. To prevent and control respiratory diseases, enhancing the barrier function of the upper respiratory tract is one of the most effective preventive measures. The present composition has the effects of both enhancing the barrier defense of the upper respiratory tract and clearing respiratory symptoms caused by external and internal evil.

[0005] To achieve the above object, the present invention provides the following solutions:

[0006] One of the technical solutions of the present invention is a Chinese veterinary medicine composition for preventing and treating respiratory diseases of newborn calves in cold northern regions, which is prepared from the following components in parts by weight: 16-24 parts of cassia twig, 16-24 parts of raw white peony root, 8-12 parts of honeysuckle, 8-12 parts of dandelion, 8-12 parts of burdock fruit, 8-12 parts of siler, 3-7 parts of honey and 3-7 parts of liquorice.

[0007] The second technical solution of the present invention is a method for preparing the Chinese veterinary drug composition, comprising the following steps:

[0008] (1) Weigh cinnamon twig, white peony root, honeysuckle, dandelion, burdock fruit, siler and liquorice according to a certain proportion, and mix and grind them;

[0009] (2) adding water to the crushed medicinal material to soak, then boiling to perform the first extraction, filtering, and obtaining an extract and medicinal residue;

[0010] (3) adding water to the residue, boiling for a second extraction, and filtering to obtain a second extract;

[0011] (4) The extracts 1 and 2 are combined, honey is added, and the mixture is concentrated to obtain the Chinese veterinary medicine composition.

[0012] The third technical solution of the present invention is a pharmaceutical preparation for preventing and treating respiratory diseases of newborn calves in cold northern regions, comprising the Chinese veterinary medicine composition.

[0013] Based on the above technical solution, the present invention has the following technical effects:

[0014] The present invention improves the traditional Yupingfeng powder, removes raw astragalus, adds cinnamon twig and raw white peony root, strengthens the lung qi deficiency improvement effect, avoids the symptoms from recurring, and preferably improves the situation of lung qi deficiency in newborn calves, reconciles the Yingwei, consolidates the Wei qi, invigorates the qi and strengthens the spleen, strengthens the body and consolidates the exterior, and forms a solid upper respiratory tract barrier effect. At the same time, with the heat-clearing and detoxifying medicine honeysuckle, dandelion, heat-clearing and throat-relief burdock fruit, honey, it is necessary to enter the lung meridian, and liquorice and the middle relieve urgency, reconcile all medicines, further remove the epidemic toxins caused by the deficiency of lung qi, and enhance the ability of the whole respiratory tract to resist external adverse factors. For the poor ventilation of the cowshed in the north in winter, the air is turbid, and the gasification disorder causes the qi disorder, and causes respiratory diseases. The Chinese veterinary medicine composition prepared by the embodiment of the present invention 1 is fed to newborn calves for preventing respiratory diseases, and the incidence rate can be reduced by 40%. The Chinese veterinary medicine composition was used to treat respiratory diseases in newborn calves. Compared with the group treated with ceftiofur sodium alone, the cure rate was increased by 13.6% and the cure time was reduced by 36.24 hours. DETAILED DESCRIPTION

[0015] Now, various exemplary embodiments of the present invention are described in detail. The methods in the examples are conventional methods unless otherwise specified, and the reagents used are conventional commercially available reagents or reagents prepared by conventional methods unless otherwise specified. This detailed description should not be considered as a limitation of the present invention, but should be understood as a more detailed description of certain aspects, features and embodiments of the present invention.

[0016] It should be understood that the terms described in the present invention are only for describing a particular embodiment and are not intended to limit the present invention. In addition, for the numerical range in the present invention, it should be understood that each intermediate value between the upper and lower limits of the scope is also specifically disclosed. The intermediate value in any stated value or stated range, and each smaller range between any other stated value or intermediate value in the described range is also included in the present invention. The upper and lower limits of these smaller ranges can be independently included or excluded in the scope.

[0017] Unless otherwise indicated, all technical and scientific terms used herein have the same meanings as those generally understood by those skilled in the art. Although the present invention describes only preferred methods and materials, any methods and materials similar or equivalent to those described herein may also be used in the implementation or testing of the present invention. All documents mentioned in this specification are incorporated by reference to disclose and describe the methods and / or materials associated with the documents. In the event of a conflict with any incorporated document, the content of this specification shall prevail.

[0018] It will be apparent to those skilled in the art that various modifications and variations may be made to the specific embodiments of the present invention description without departing from the scope or spirit of the present invention. Other embodiments derived from the present invention description will be apparent to the skilled artisan. The present invention description and examples are exemplary only.

[0019] The words “include,” “including,” “have,” “contain,” etc. used in this document are open-ended terms, meaning including but not limited to.

[0020] The technical solutions described in the present invention, unless otherwise specified, are all conventional solutions in the art, and the reagents or raw materials used, unless otherwise specified, are purchased from commercial channels or have been disclosed.

[0021] The embodiment of the present invention provides a Chinese veterinary medicine composition for preventing and treating respiratory diseases of newborn calves in cold northern regions. The composition is prepared from the following components in parts by weight: 16 to 24 parts of cassia twig, 16 to 24 parts of raw white peony root, 8 to 12 parts of honeysuckle, 8 to 12 parts of dandelion, 8 to 12 parts of burdock fruit, 8 to 12 parts of siler, 3 to 7 parts of honey and 3 to 7 parts of liquorice.

[0022] In some specific embodiments, the following components are included in parts by weight: 20 parts of cinnamon twig, 20 parts of raw white peony root, 10 parts of honeysuckle, 10 parts of dandelion, 10 parts of burdock fruit, 10 parts of siler, 5 parts of honey and 5 parts of licorice.

[0023] The present invention also provides a method for preparing the Chinese veterinary drug composition, comprising the following steps:

[0024] (1) Weigh cinnamon twig, white peony root, honeysuckle, dandelion, burdock fruit, siler and liquorice according to a certain proportion, and mix and grind them;

[0025] (2) adding water to the crushed medicinal material to soak, then boiling to perform the first extraction, filtering, and obtaining an extract and medicinal residue;

[0026] (3) adding water to the residue, boiling for a second extraction, and filtering to obtain a second extract;

[0027] (4) The extracts 1 and 2 are combined, honey is added, and the mixture is concentrated to obtain the Chinese veterinary medicine composition.

[0028] In some specific embodiments, the conditions for the first extraction are: the weight ratio of the medicinal material to water is 1:(8-12), the soaking time is 2-4 hours, and the extraction time is 1-3 hours.

[0029] In some specific embodiments, the conditions for the second extraction are: the weight ratio of the medicinal residue to water is 1:(6-10), and the extraction time is 1-3 hours.

[0030] In some specific embodiments, the concentration method is: concentrating under the conditions of a pressure of -0.03 to -0.08 MPa and a temperature of 60 to 80°C, and concentrating to a relative density of 1.08 to 1.25 at 20-30°C.

[0031] The embodiment of the present invention also provides a pharmaceutical preparation for preventing and treating respiratory diseases of newborn calves in northern cold regions, comprising the Chinese veterinary medicine composition.

[0032] In some specific embodiments, a pharmaceutically acceptable excipient is also included.

[0033] When calves suffer from respiratory diseases, there are six common clinical manifestations: coughing, fever, lethargy, increased nasal discharge, loss of appetite and increased eye discharge. These are very important indicators that can identify whether cattle have respiratory diseases and the degree of infection.

[0034] Example 1

[0035] The Chinese veterinary medicine composition comprises the following components in parts by weight: 20 parts of cassia twig, 20 parts of raw white peony root, 10 parts of honeysuckle, 10 parts of dandelion, 10 parts of burdock fruit, 10 parts of siler, 5 parts of honey and 5 parts of liquorice.

[0036] The preparation method is:

[0037] (1) Weigh cinnamon twig, white peony root, honeysuckle, dandelion, burdock fruit, siler and liquorice according to a certain proportion, and mix and grind them;

[0038] (2) adding 10 times the weight of water to the crushed medicinal material and soaking it for 3 hours, then boiling it for the first extraction, the extraction time is 2 hours, filtering, and obtaining an extract solution and a medicinal residue;

[0039] (3) adding 8 times the weight of water to the residue, boiling and performing a second extraction for 2 hours, filtering to obtain extract 2;

[0040] (4) Combine the extracts 1 and 2, add honey, and concentrate at a pressure of -0.05 MPa and a temperature of 70° C. until the relative density at room temperature is 1.2, thereby obtaining the Chinese veterinary medicine composition.

[0041] Example 2

[0042] The Chinese veterinary medicine composition comprises the following components in parts by weight: 16 parts of cassia twig, 16 parts of raw white peony root, 12 parts of honeysuckle, 12 parts of dandelion, 8 parts of burdock fruit, 8 parts of siler, 7 parts of honey and 7 parts of liquorice.

[0043] The preparation method is:

[0044] (1) Weigh cinnamon twig, white peony root, honeysuckle, dandelion, burdock fruit, siler and liquorice according to a certain proportion, and mix and grind them;

[0045] (2) adding 10 times the weight of water to the crushed medicinal material and soaking it for 3 hours, then boiling it for the first extraction, the extraction time is 2 hours, filtering, and obtaining an extract solution and a medicinal residue;

[0046] (3) adding 8 times the weight of water to the residue, boiling and performing a second extraction for 2 hours, filtering to obtain extract 2;

[0047] (4) Combine the extracts 1 and 2, add honey, and concentrate at a pressure of -0.05 MPa and a temperature of 70° C. until the relative density at room temperature is 1.2, thereby obtaining the Chinese veterinary medicine composition.

[0048] Example 3

[0049] The Chinese veterinary medicine composition comprises the following components in parts by weight: 24 parts of cassia twig, 24 parts of raw white peony root, 8 parts of honeysuckle, 8 parts of dandelion, 12 parts of burdock fruit, 12 parts of siler, 5 parts of honey and 3 parts of liquorice.

[0050] The preparation method is:

[0051] (1) Weigh cinnamon twig, white peony root, honeysuckle, dandelion, burdock fruit, siler and liquorice according to a certain proportion, and mix and grind them;

[0052] (2) adding 10 times the weight of water to the crushed medicinal material and soaking it for 3 hours, then boiling it for the first extraction, the extraction time is 2 hours, filtering, and obtaining an extract solution and a medicinal residue;

[0053] (3) adding 8 times the weight of water to the residue, boiling and performing a second extraction for 2 hours, filtering to obtain extract 2;

[0054] (4) Combine the extracts 1 and 2, add honey, and concentrate at a pressure of -0.05 MPa and a temperature of 70° C. until the relative density at room temperature is 1.2, thereby obtaining the Chinese veterinary medicine composition.

[0055] Effect example

[0056] The experiment was conducted at a cattle farm of Fuyida Animal Husbandry Co., Ltd. in Yushu City, Jilin Province. The experiment was chosen to be carried out in early December, with a test period of 30 days and repeated three times.

[0057] In each experiment, 40 newborn calves with the same birth time and the same health status were selected and randomly divided into a control group and an experimental group, and numbered, with 20 calves in each group. The control group was fed with normal feed, and the experimental group was supplemented with the Chinese veterinary medicine composition prepared in Example 1 (20 g / head, taken every other day) for prevention on the basis of the control group, and the experimental period was 30 days.

[0058] When calves suffer from respiratory diseases, there are six common clinical manifestations: cough, fever, lethargy, increased nasal secretions, loss of appetite and increased eye secretions. The presence of any two of these symptoms is used as the diagnostic standard for respiratory diseases.

[0059] If the calves showed respiratory disease symptoms during the experiment, the control group was treated with veterinary ceftiofur sodium injection at a dosage of 5 mg / kg. The experimental group took the Chinese veterinary drug composition prepared in Example 1 (40 g / head / day) on the basis of the control group, and resumed the preventive dosage after recovery.

[0060] During the experiment, the basal diets of each group were exactly the same, and drinking water was free. The incidence, cure rate, and cure time of respiratory diseases in the two groups of calves during the experiment were calculated. The results are shown in Table 1.

[0061] Table 1

[0062] Total number of heads Number of sick heads Prevalence Number of cured heads Cure rate Average healing time Experimental Group 60 17 28.3％ 16 94.1％ 96.44h Control group 60 41 68.3％ 33 80.5％ 132.68h

[0063] As shown in Table 1, the Chinese veterinary medicine composition prepared in Example 1 of the present invention is used to feed newborn calves for preventing respiratory diseases, and the incidence rate can be reduced by 40%. Compared with the group treated with ceftiofur sodium alone, the Chinese veterinary medicine composition is used to treat respiratory diseases in newborn calves, and the cure rate is increased by 13.6%, and the cure time is reduced by 36.24h.

[0064] In the north, the temperature is low in late autumn, early spring and winter, with a large temperature difference and dry air. In addition, the lungs are delicate organs that prefer warm and humid environments and hate cold and dryness. At the same time, the lung qi of newborn calves is still relatively weak, and they are very susceptible to respiratory diseases at this time. The upper respiratory tract is the gateway to the respiratory tract, and the use of prescriptions to consolidate the surface has a better preventive effect. Because the lung qi is weak and is affected by external evil, the cold evil directly attacks the lungs, causing the qi to become weak, and the epidemic toxins take the opportunity to invade. The surface is not solid, and the external evil is not eliminated, then lung symptoms occur.

[0065] Yupingfeng powder is composed of astragalus, atractylodes and saposhnikovia, and has the effects of invigorating qi, consolidating the exterior, and stopping sweating. It is clinically used for the card of infirm exterior defense caused by spleen and lung qi deficiency. The present invention improves traditional Yupingfeng powder, removes raw astragalus, adds cassia twig and raw white peony root, strengthens the lung qi deficiency and improves the effect, avoids repeated symptoms, and will preferably improve the situation of lung qi deficiency in newborn calves, reconcile the Yingwei, consolidate the Wei qi, invigorate qi and strengthen the spleen, strengthen the body and consolidate the exterior, and form a solid upper respiratory tract barrier effect. At the same time, with the heat-clearing and detoxifying medicine honeysuckle, dandelion, heat-clearing and relieving throat burdock, honey, it is necessary to enter the lung meridian, and liquorice and the middle relieve urgency, reconcile all medicines, further remove the epidemic toxins caused by the deficiency of lung qi, and enhance the ability of the whole respiratory tract to resist external adverse factors. For poor ventilation in the cowshed in the north in winter, turbid air, gasification disorder, cause qi disorder, and cause respiratory diseases.

[0066] Obviously, the above embodiments of the present invention are merely examples for clearly illustrating the present invention, and are not intended to limit the implementation methods of the present invention. For ordinary technical users in the relevant field, other different forms of changes or modifications can be made on the basis of the above description. It is not necessary and impossible to list all the implementation methods here. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the protection scope of the claims of the present invention.

Claims

1. A Chinese veterinary medicine composition for preventing and treating respiratory diseases of newborn calves in cold northern regions, characterized in that: The invention is prepared from the following components in parts by weight: 16-24 parts of cassia twig, 16-24 parts of raw white peony root, 8-12 parts of honeysuckle, 8-12 parts of dandelion, 8-12 parts of burdock fruit, 8-12 parts of siler, 3-7 parts of honey and 3-7 parts of liquorice.

2. The Chinese veterinary medicine composition according to claim 1, characterized in that: The invention comprises the following components in parts by weight: 20 parts of cassia twig, 20 parts of raw white peony root, 10 parts of honeysuckle, 10 parts of dandelion, 10 parts of burdock fruit, 10 parts of siler, 5 parts of honey and 5 parts of liquorice.

3. The method for preparing the Chinese veterinary drug composition according to claim 1 or 2, characterized in that: The following steps are involved: (1) Weigh cinnamon twig, white peony root, honeysuckle, dandelion, burdock fruit, siler and liquorice according to a certain proportion, and mix and grind them; (2) adding water to the crushed medicinal material to soak, then boiling to perform the first extraction, filtering, and obtaining an extract and medicinal residue; (3) adding water to the residue, boiling for a second extraction, and filtering to obtain a second extract; (4) The extracts 1 and 2 are combined, honey is added, and the mixture is concentrated to obtain the Chinese veterinary medicine composition.

4. The preparation method according to claim 3 is characterized in that the conditions for the first extraction are: the weight ratio of medicinal materials to water is 1:(8-12), the soaking time is 2-4 hours, and the extraction time is 1-3 hours.

5. The preparation method according to claim 3, characterized in that the conditions for the second extraction are: the weight ratio of the medicinal residue to water is 1:(6-10), and the extraction time is 1-3 hours.

6. The preparation method according to claim 3 is characterized in that the concentration method is: concentrating under the conditions of a pressure of -0.03 to -0.08 MPa and a temperature of 60 to 80°C, and concentrating to a relative density of 1.08 to 1.25 at 20 to 30°C.

7. A pharmaceutical preparation for preventing and treating respiratory diseases in newborn calves in cold northern regions, characterized in that: Including the Chinese veterinary medicine composition as claimed in claim 1 or 2.

8. The pharmaceutical preparation according to claim 7, characterized in that Pharmaceutically acceptable excipients are also included.