Traditional Chinese medicine compound extract for improving oral environment as well as preparation method and application of traditional Chinese medicine compound extract

Abstract

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine compound extract for improving oral environment and a preparation method and application thereof, and the traditional Chinese medicine compound extract comprises the following components in parts by weight: 10-15 parts of radix puerariae, 6-10 parts of coptis chinensis, 10-15 parts of honeysuckle, 10-15 parts of gallnut, 10-15 parts of scutellaria baicalensis, 10-15 parts of dandelion, 10-15 parts of wild chrysanthemum flower, 6-10 parts of raw liquorice, 10-15 parts of radix angelicae and 15-20 parts of asarum. The traditional Chinese medicine compound extract disclosed by the invention is green, natural and free of any chemical product, and by adopting a compound decoction extraction mode, the traditional Chinese medicine compound extract disclosed by the invention can more effectively enable medicines to exert the effects of monarch, minister, assistant and guide in a compound so as to achieve the effect of enhancing the effect.

Description

Technical Field

[0001] The invention relates to the field of traditional Chinese medicine, and in particular to a traditional Chinese medicine composite extract for improving oral environment and a preparation method thereof. Background Art

[0002] Dental and oral problems have always been common problems that plague people's oral health. There are a large number of bacteria in the oral cavity. Some studies have shown that this part is the part with the most types of flora in the whole body and is closely related to the intestinal flora. Under normal circumstances, the human oral cavity is in a state of ecological balance, but under bad eating habits, bad living habits, physical factors and disease conditions, the oral flora can be unbalanced, resulting in changes in the abundance and diversity of the flora, and some strains multiplying in large numbers. This leads to symptoms such as loose teeth, bad breath, oral discomfort, bad breath, increased plaque, swollen and bleeding gums, increased tartar, sticky mouth, and thick tongue coating. Adaptive drug treatment is carried out for these problems, and local oral treatment such as periodontal cleaning, removal of plaque and tartar, prevention and treatment of caries, and treatment of periodontal diseases are carried out at the same time. Proper use of oral care products in daily life is an effective way to protect and improve the oral cavity and teeth.

[0003] Traditional Chinese medicine theory uses a compound prescription of monarch, minister, assistant and envoy as a common treatment method. The effect produced by the appropriate combination of drugs is not just a simple superposition, but a compound synergy and balanced coordination, which can eliminate evil and strengthen the body at the same time, ensuring the balance of yin and yang in the body. The theory of this compound has been proven by many scholars, and its effect is stronger than the use of a single extract. Summary of the invention

[0004] In order to solve the problems of the prior art, the present invention provides a traditional Chinese medicine composite extract for improving the oral environment, and a preparation method and application thereof.

[0005] To achieve the above object, the present invention proposes the following scheme:

[0006] According to one aspect of an embodiment of the present invention, a Chinese herbal composite extract for improving the oral environment is provided, wherein the Chinese herbal composite extract comprises the following components in parts by weight: 10-15 parts of Pueraria root, 6-10 parts of Coptis chinensis, 10-15 parts of Honeysuckle, 10-15 parts of Galla chinensis, 10-15 parts of Scutellaria baicalensis, 10-15 parts of Taraxacum mongolicum, 10-15 parts of Chrysanthemum indicum, 6-10 parts of raw licorice, 10-15 parts of Angelica dahurica, and 15-20 parts of Asarum.

[0007] According to another aspect of an embodiment of the present invention, a method for preparing a composite extract of traditional Chinese medicine for improving oral environment is provided, comprising the steps of:

[0008] (1) Grinding the component raw materials, soaking them in deionized water of 8 to 10 times the volume, boiling them under pressure, and filtering them through a sieve to obtain a drug solution a;

[0009] (2) adding 2 to 6 times the volume of deionized water to the residue in step (1), continuing to boil under pressure, and filtering through a sieve to obtain a drug solution b;

[0010] (3) mixing the drug solution a and the drug solution b, concentrating them, and obtaining a filtrate c after centrifugation and filtration;

[0011] (4) drying the filtrate c in step (3) to form a Chinese medicine composite extract.

[0012] Furthermore, the soaking time in step (1) is 8 to 15 hours, and the pressurization pressure is 1.05 Kp to 1.10 Kp;

[0013] The boiling time in step (1) and step (2) is 1.5 hours, and the sieve is 100 mesh;

[0014] The centrifugation parameters in step (3) are 300 rpm, the centrifugation time is 15 minutes, and the filtration is performed using a 1 / 110 mm diameter qualitative filter paper.

[0015] According to another aspect of the embodiments of the present invention, a use of a composite extract of traditional Chinese medicine for improving oral environment as an additive in an oral care product is provided.

[0016] Furthermore, the oral care products include toothpaste, mouthwash, instant powder, and compressed tablets.

[0017] Furthermore, the Chinese medicine composite extract is suitable for mixing with sodium alginate, olive oil, CaCl 2 , and chitosan are used to wrap the calcium alginate microsphere preparation.

[0018] The main ingredients of the invention are all traditional Chinese medicinal materials, which are compounded under the guidance of traditional Chinese medicine theory, are green and natural, and do not contain any chemical products.

[0019] The Chinese medicine compound extract of the present invention changes the previous method of extracting and mixing single medicines separately. Under the guidance of traditional Chinese medicine theory, the compound decoction extraction method is adopted, which can more effectively enable the medicines to play the role of monarch, minister, assistant and envoy in the compound and achieve the effect of enhancing the effect.

[0020] The Chinese medicine composite extract of the present invention can be prepared in the form of calcium alginate microspheres as required. The preparation mainly consists of sodium alginate, olive oil, CaCl 2The main purpose of the preparation form composed of microspheres and chitosan is to improve the surface morphology of microspheres, control the drug release rate, reduce the sudden release of drugs, alleviate the unpleasant taste of Chinese medicine preparations when they stay in the mouth, and at the same time, allow the ingredients that naturally enter the digestive system to remain in the stomach for a longer period of time and play their role. It is suitable for use in oral instant powders, toothpastes and other products. DETAILED DESCRIPTION

[0021] The following will clearly and completely describe the concept of the present invention and the technical effects produced in combination with the embodiments, so as to fully understand the purpose, characteristics and effects of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, other embodiments obtained by technicians in this field without creative work are all within the scope of protection of the present invention. The test methods used in the embodiments are all conventional methods unless otherwise specified; the materials, reagents, etc. used, unless otherwise specified, can all be reagents and materials obtained from commercial channels.

[0022] Example 1

[0023] A traditional Chinese medicine composite extract for improving oral environment, comprising the following components in parts by weight:

[0024] 10 parts of Puerariae Radix, 6 parts of Coptidis Rhizoma, 10 parts of Flos Lonicerae, 10 parts of Galla Chinensis, 10 parts of Baical Scutellariae, 10 parts of Herba Taraxaci, 10 parts of Flos Chrysanthemi Indici, 6 parts of Radix Glycyrrhizae, 10 parts of Radix Angelicae Dahuricae, and 15 parts of Herba Asari.

[0025] A method for preparing a traditional Chinese medicine composite extract for improving oral environment, comprising the following steps:

[0026] (1) The above Chinese medicine raw materials were ground, added into 8 times the volume of deionized water and soaked for 8 hours, heated and boiled for 1.5 hours under a pressure of 1.05Kp, and then filtered through a 100# sieve to obtain a liquid medicine a.

[0027] (2) Add deionized water twice the volume of the residue to the residue in step (1), continue to boil under pressure for 1.5 hours, and then filter out the solution through a 100# sieve to obtain solution b.

[0028] (3) The drug solutions a and b were combined and concentrated to obtain a 1:10 liquid, which was centrifuged at 300 rpm for 15 minutes and then passed through a No. 1 filter paper (1 / 110 mm diameter qualitative filter paper) to obtain a filtrate c.

[0029] (4) The filtrate c is concentrated, dried or freeze-dried to form a Chinese medicine composite extract.

[0030] Example 2

[0031] A traditional Chinese medicine composite extract for improving oral environment, comprising the following components in parts by weight:

[0032] 13 parts of kudzu root, 8 parts of coptis root, 13 parts of honeysuckle, 13 parts of gallnut, 13 parts of scutellaria, 13 parts of dandelions, 13 parts of wild chrysanthemum, 8 parts of raw liquorice, 13 parts of the white angelica, and 18 parts of asarum.

[0033] A method for preparing a traditional Chinese medicine composite extract for improving oral environment, comprising the following steps:

[0034] (1) The above Chinese medicine raw materials were ground, added into 9 times the volume of deionized water and soaked for 10 hours, heated and boiled for 1.5 hours under a pressure of 1.05Kp, and then filtered through a 100# sieve to obtain a liquid medicine a.

[0035] (2) Add deionized water in an amount of 4 times the volume of the residue to the residue in step (1), continue to boil under pressure for 1.5 hours, and then filter out the solution through a 100# sieve to obtain solution b.

[0036] (3) The drug solutions a and b were combined and concentrated to obtain a 1:10 liquid, which was centrifuged at 300 rpm for 15 minutes and then passed through a No. 1 filter paper (1 / 110 mm diameter qualitative filter paper) to obtain a filtrate c.

[0037] (4) The filtrate c is concentrated, dried or freeze-dried to form a Chinese medicine composite extract.

[0038] Example 3

[0039] A traditional Chinese medicine composite extract for improving oral environment, comprising the following components in parts by weight:

[0040] 15 parts of Puerariae Radix, 10 parts of Coptidis Rhizoma, 15 parts of Flos Lonicerae, 15 parts of Galla Chinensis, 15 parts of Baical Scutellariae, 15 parts of Herba Taraxaci, 15 parts of Flos Chrysanthemi Indici, 10 parts of Radix Glycyrrhizae, 15 parts of Radix Angelicae Dahuricae, 20 parts of Herba Asari.

[0041] A method for preparing a traditional Chinese medicine composite extract for improving oral environment, comprising the following steps:

[0042] (1) The above Chinese medicinal materials were ground, added into 10 times the volume of deionized water and soaked for 15 hours, heated and boiled for 1.5 hours under a pressure of 1.10Kp, and then filtered through a 100# sieve to obtain a medicinal solution a.

[0043] (2) Add deionized water in an amount of 6 times the volume of the residue to the residue in step (1), continue to boil under pressure for 1.5 hours, and then filter out the solution through a 100# sieve to obtain solution b.

[0044] (3) The drug solutions a and b were combined and concentrated to obtain a 1:10 liquid, which was centrifuged at 300 rpm for 15 minutes and then passed through a No. 1 filter paper (1 / 110 mm diameter qualitative filter paper) to obtain a filtrate c.

[0045] (4) The filtrate c is concentrated, dried or freeze-dried to form a Chinese medicine composite extract.

[0046] The Chinese medicine extract of the present invention is derived from kudzu root, coptis root, honeysuckle, gallnut, scutellaria, dandelion, wild chrysanthemum and raw liquorice. The effective components of kudzu root are isoflavone compounds, etc., which have the effects of anti-oxidation, promoting osteoblast proliferation, differentiation and mineralization, and can make osteoclast cavitation change, thereby reducing the area of ​​bone resorption pits, and have the effects of anti-oxidation, anti-inflammatory, immune regulation, and promoting wound healing. The effective components of coptis root extract are berberine, ethyl gallate, etc., which have the effects of antibacterial, anti-inflammatory, analgesic, inhibiting inflammatory tissue hyperplasia and granuloma formation, and can promote the proliferation of fibroblasts and the synthesis of collagen. Berberine has an inhibitory effect on Staphylococcus aureus, beta-hemolytic streptococcus, etc., and has 120 targets for Helicobacter pylori. The effective ingredients of the Chinese gallnut extract include tannin, gallic acid, methyl gallate, ethyl gallate, etc., which can inhibit the growth and metabolism of caries-causing bacteria, inhibit the demineralization of tooth hard tissues and promote remineralization, have a good anti-caries effect, and have a significant inhibitory effect on viscose actinomycetes, Candida albicans, Porphyromonas gingivalis, Candida albicans, Streptococcus mutans, etc., and significantly improve symptoms such as bad breath. The honeysuckle extract is rich in effective ingredients such as honeysuckle flavonoids and honeysuckle glycosides, which have a good killing and inhibitory effect on Staphylococcus aureus, hemolytic Streptococcus and various viruses, and can effectively eliminate symptoms such as oral ulcers, bitter mouth and dry mouth. Dandelion and wild chrysanthemum have the effect of clearing heat and detoxifying. The main ingredients of honeysuckle glycosides, isoliquiritigenin, taraxacinol, taraxasterol, wild chrysanthemum ketone, wild chrysanthemum lactone and other effective ingredients have good killing or inhibitory effects on various fungi such as Staphylococcus aureus and hemolytic streptococci, and can effectively improve the flora environment in the oral cavity. The effective ingredients of Scutellaria baicalensis extract are baicalin and baicalein, which have different degrees of inhibitory effects on Gram-negative bacteria, have a protective function on periodontal ligament cells, and can prevent oral fungal infections. The target points of Scutellaria baicalensis for Helicobacter pylori can reach 106. Raw licorice clears heat and detoxifies, and plays a harmonizing role in the prescription. Its main ingredients such as glycyrrhizin and glycyrrhetinic acid have a good soothing effect on the oral mucosa and improve oral ulcers. Angelica dahurica can treat periodontal disease by regulating pro-inflammatory mediators and improving the proliferation of gingival epithelial tissue, and has the potential to treat periodontitis. Asarum can upregulate the expression of heme oxygenase-1 (HO-1) and inhibit the NF-κB pathway to exert anti-inflammatory effects and protect gums.

[0047] The Chinese medicinal compound extract for improving the oral microenvironment and helping to strengthen teeth of the present invention can be used as an additive in oral care products, such as toothpaste, mouthwash, instant powder, compressed tablets, and the like.

[0048] The Chinese medicine composite extract of the present invention can play a role in strengthening teeth. The Chinese medicine composite extract of the present invention can be mixed with sodium alginate, olive oil, CaCl 2 , chitosan, etc. to form calcium alginate microsphere preparations.

[0049] The main ingredients of the invention are all traditional Chinese medicinal materials, which are compounded under the guidance of traditional Chinese medicine theory, are green and natural, and do not contain any chemical products.

[0050] The Chinese medicine compound extract of the present invention changes the previous method of extracting and mixing single medicines separately. Under the guidance of traditional Chinese medicine theory, the compound decoction extraction method is adopted, which can more effectively enable the medicines to play the role of monarch, minister, assistant and envoy in the compound and achieve the effect of enhancing the effect.

[0051] The Chinese medicine composite extract of the present invention can be prepared in the form of calcium alginate microspheres as required. The preparation mainly consists of sodium alginate, olive oil, CaCl 2 The main purpose of the preparation form composed of microspheres and chitosan is to improve the surface morphology of microspheres, control the drug release rate, reduce the sudden release of drugs, alleviate the unpleasant taste of Chinese medicine preparations when they stay in the mouth, and at the same time, allow the ingredients that naturally enter the digestive system to remain in the stomach for a longer period of time and play their role. It is suitable for use in oral instant powders, toothpastes and other products.

[0052] Based on the above, the present invention proposes the following technical solutions:

[0053] 1. A Chinese medicine composite extract for improving oral environment, wherein the Chinese medicine composite extract comprises the following components in parts by weight: 10-15 parts of Pueraria root, 6-10 parts of Coptis chinensis, 10-15 parts of Honeysuckle, 10-15 parts of Galla chinensis, 10-15 parts of Scutellaria baicalensis, 10-15 parts of Taraxacum mongolicum, 10-15 parts of Chrysanthemum indicum, 6-10 parts of raw Licorice, 10-15 parts of Angelica dahurica, and 15-20 parts of Asarum.

[0054] 2. The Chinese herbal compound extract according to 1, wherein:

[0055] The Chinese medicine composite extract comprises the following components in parts by weight: 10 parts of kudzu root, 6 parts of coptis root, 10 parts of honeysuckle, 10 parts of gallnut, 10 parts of scutellaria, 10 parts of dandelion, 10 parts of wild chrysanthemum, 6 parts of raw licorice, 10 parts of angelica dahurica, and 15 parts of asarum.

[0056] 3. The Chinese medicine composite extract according to 1, wherein:

[0057] The Chinese medicine composite extract comprises the following components in parts by weight: 13 parts of kudzu root, 8 parts of coptis root, 13 parts of honeysuckle, 13 parts of gallnut, 13 parts of scutellaria, 13 parts of dandelion, 13 parts of wild chrysanthemum, 8 parts of raw licorice, 13 parts of angelica dahurica, and 18 parts of asarum.

[0058] 4. The Chinese herbal compound extract according to item 1, wherein:

[0059] The Chinese medicine composite extract comprises the following components in parts by weight: 15 parts of kudzu root, 10 parts of coptis root, 15 parts of honeysuckle, 15 parts of gallnut, 15 parts of scutellaria, 15 parts of dandelion, 15 parts of wild chrysanthemum, 10 parts of raw licorice, 15 parts of angelica dahurica, and 20 parts of asarum.

[0060] 5. A method for preparing the composite extract of traditional Chinese medicine according to 1, comprising the steps of:

[0061] (1) Grinding the component raw materials, soaking them in deionized water of 8 to 10 times the volume, boiling them under pressure, and filtering them through a sieve to obtain a drug solution a;

[0062] (2) adding 2 to 6 times the volume of deionized water to the residue in step (1), continuing to boil under pressure, and filtering through a sieve to obtain a drug solution b;

[0063] (3) mixing the drug solution a and the drug solution b, concentrating them, and obtaining a filtrate c after centrifugation and filtration;

[0064] (4) drying the filtrate c in step (3) to form a Chinese medicine composite extract.

[0065] 6. The method according to 5, wherein:

[0066] The soaking time in step (1) is 8 to 15 hours, and the pressurization pressure is 1.05 Kp to 1.10 Kp;

[0067] The boiling time in step (1) and step (2) is 1.5 hours, and the sieve is 100 mesh;

[0068] The centrifugation parameters in step (3) are 300 rpm, the centrifugation time is 15 minutes, and the filtration is performed using a 1 / 110 mm diameter qualitative filter paper.

[0069] 7. Use of a Chinese herbal compound extract for improving oral environment as described in 1 as an additive in oral care products.

[0070] 8. The use according to 7, wherein the oral care product comprises toothpaste, mouthwash, instant powder, and compressed tablet.

[0071] 9. The use according to item 7, wherein the Chinese herbal compound extract is suitable for mixing with sodium alginate, olive oil, CaCl 2 , and chitosan are used to wrap the calcium alginate microsphere preparation.

[0072] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes may be made to the embodiments and combinations of elements may be made without departing from the principles and spirit of the invention, the scope of the invention being defined by the appended claims and their equivalents.

Claims

1. A Chinese herbal compound extract for improving oral environment, wherein: The traditional Chinese medicine composite extract comprises the following components in parts by weight: 10-15 parts of kudzu root, 6-10 parts of coptis root, 10-15 parts of honeysuckle, 10-15 parts of gallnut, 10-15 parts of scutellaria, 10-15 parts of dandelion, 10-15 parts of wild chrysanthemum, 6-10 parts of raw licorice, 10-15 parts of angelica dahurica, and 15-20 parts of asarum.

2. The Chinese medicine composite extract according to claim 1, wherein: The Chinese medicine composite extract comprises the following components in parts by weight: 10 parts of kudzu root, 6 parts of coptis root, 10 parts of honeysuckle, 10 parts of gallnut, 10 parts of scutellaria, 10 parts of dandelion, 10 parts of wild chrysanthemum, 6 parts of raw licorice, 10 parts of angelica dahurica, and 15 parts of asarum.

3. The Chinese medicine composite extract according to claim 1, wherein: The Chinese medicine composite extract comprises the following components in parts by weight: 13 parts of kudzu root, 8 parts of coptis root, 13 parts of honeysuckle, 13 parts of gallnut, 13 parts of scutellaria, 13 parts of dandelion, 13 parts of wild chrysanthemum, 8 parts of raw licorice, 13 parts of angelica dahurica, and 18 parts of asarum.

4. The Chinese medicine composite extract according to claim 1, wherein: The Chinese medicine composite extract comprises the following components in parts by weight: 15 parts of Puerariae Radix, 10 parts of Coptidis Rhizoma, 15 parts of Flos Lonicerae, 15 parts of Galla Chinensis, 15 parts of Baical Scutellariae, 15 parts of Herba Taraxaci, 15 parts of Flos Chrysanthemi Indici, 10 parts of Radix Glycyrrhizae, 15 parts of Radix Angelicae Dahuricae, 20 parts of Herba Asari.

5. A method for preparing the Chinese medicine composite extract according to claim 1, comprising the steps of: (1) Grinding the component raw materials, soaking them in deionized water of 8 to 10 times the volume, boiling them under pressure, and filtering them through a sieve to obtain a drug solution a; (2) adding 2 to 6 times the volume of deionized water to the residue in step (1), continuing to boil under pressure, and filtering through a sieve to obtain a drug solution b; (3) mixing the drug solution a and the drug solution b, concentrating them, and obtaining a filtrate c after centrifugation and filtration; (4) drying the filtrate c in step (3) to form a Chinese medicine composite extract.

6. The method according to claim 5, wherein: The soaking time in step (1) is 8 to 15 hours, and the pressurization pressure is 1.05 Kp to 1.10 Kp; The boiling time in step (1) and step (2) is 1.5 hours, and the sieve is 100 mesh; The centrifugation parameters in step (3) are 300 rpm, the centrifugation time is 15 minutes, and the filtration is performed using a 1 / 110 mm diameter qualitative filter paper.

7. Use of the Chinese herbal compound extract for improving oral environment according to claim 1 as an additive in oral care products.

8. The use according to claim 7, wherein: The oral care products include toothpaste, mouthwash, instant powder and compressed tablets.

9. The use according to claim 7, wherein: The traditional Chinese medicine composite extract is suitable for being packaged with sodium alginate, olive oil, CaCl2 and chitosan to form a calcium alginate microsphere preparation.