Acne-removing Chinese medicine composition and application thereof

Abstract

The invention provides an anti-acne Chinese medicine composition and its application, and relates to the technical field of traditional Chinese medicine. The anti-acne Chinese medicine composition includes the following raw material components by weight: 45-71 parts of Paris polyphylla, 15-25 parts of mulberry leaves, 15-25 parts of safflower, 26-38 parts of honeysuckle, 15-26 parts of frangipani, 26-38 parts of scutellaria, 33-50 parts of phellodendron, 46-73 parts of green tea, 60-90 parts of salvia miltiorrhiza, 49-78 parts of notoginseng powder, 28-40 parts of pearl powder, and 30-45 parts of mint leaves. Through the reasonable combination of Paris polyphylla + safflower, salvia miltiorrhiza + phellodendron, pearl powder + notoginseng powder, mulberry leaves + safflower, external application on the affected part can effectively dissolve hair follicle keratin, make acne and closed acne fall off automatically without damaging normal skin, repair acne scars, and the effective rate is more than 95%. With the special ball-shaped bottle sealed packaging design, it is easy to apply and use, and can be effectively used to treat acne.

Description

Technical Field

[0001] The invention belongs to the field of traditional Chinese medicine, and specifically relates to an acne-removing traditional Chinese medicine composition and application thereof. Background Art

[0002] Acne, also known as pimples, is divided into non-inflammatory lesions (blackheads, whiteheads) and inflammatory lesions (inflammatory papules, pustules, nodules, cysts). Different types of acne and different degrees of acne have different treatment methods. After the acne is cured, the secondary lesions left behind include red acne marks, dark brown / brown acne marks, and acne scars (including acne pits and scars protruding from the skin surface). The treatment of acne is currently mainly based on Western medicine, but Western medicine has greater side effects and is prone to cause other diseases.

[0003] Chinese medicine for treating acne, such as China invention patent publication number CN105381096A discloses a medicine for treating acne caused by heat toxins, which is mainly made of the following raw materials in weight proportions: 6-10 parts of coptis root, 8-10 parts of scutellaria, 12-18 parts of phellodendron, 8-12 parts of mint, 8-12 parts of mulberry leaves, 6-10 parts of cicada shells, 12-18 parts of wild chrysanthemum, 12-18 parts of honeysuckle, 8-12 parts of dandelion, 6-10 parts of salvia miltiorrhiza, 8-12 parts of moutan bark, 6-10 parts of red peony root, 8-12 parts of rhubarb, and 4-6 parts of licorice. 15 kinds of natural Chinese medicines are selected for scientific compatibility, the formula is simple, and the synergistic effect of each raw material medicine plays the effect of clearing away heat and detoxifying, promoting blood circulation and removing blood stasis, with quick effect, treating both the symptoms and the root cause, and no toxic side effects, and the preparation method is simple, easy to take, and low cost. The effective rate reaches more than 97.5%. However, the drug is an oral preparation, which has the disadvantage of a large dosage and certain side effects. Chinese invention patent publication number CN109303835A discloses a Chinese herbal wine tincture for external use to treat acne. Seven-leafed flos strychnifolia, rhubarb, honeysuckle, jasmine, scutellaria, phellodendron, sophora flavescens, green tea, salvia miltiorrhiza, part A of Panax notoginseng powder, pearl powder and mint leaves are sealed and soaked in white rice wine, taken out, filtered, seven-leafed flos strychnifolia pollen, salvia miltiorrhiza powder, green tea powder and part B of Panax notoginseng powder are added to the filtrate, and then canned, sealed, soaked, taken out, filtered, pure water is added to the filtrate and mixed, so as to obtain a Chinese herbal wine tincture for external use to treat acne, which can effectively penetrate the stratum corneum, dissolve hair follicle oil keratin plugs, astringe suppurative acne, make acne and closed comedones fall off automatically when washing the face without damaging normal skin, thereby repairing acne scars, but the effect of the above-mentioned drugs needs to be further improved. Summary of the invention

[0004] The present invention aims to develop an acne-removing composition that can be used externally and has a good acne-removing effect in view of the problems existing in the prior art. By rationally combining Paris polyphylla + safflower, Salvia miltiorrhiza + Phellodendron amurense, pearl powder + Panax notoginseng powder, and mulberry leaf + safflower, applying externally on the affected area can effectively dissolve the keratin of the hair follicles, so that acne and closed acne fall off automatically without damaging normal skin, and repair acne scars. In addition, the composition is designed with a special ball-shaped bottle for sealing and packaging, is easy to apply and use, and can be effectively used to treat acne.

[0005] One of the purposes of the present invention is to provide an acne-removing Chinese medicine composition, which comprises the following raw material components by weight: 45-71 parts of Paris polyphylla, 15-25 parts of mulberry leaves, 15-25 parts of safflower, 26-38 parts of honeysuckle, 15-26 parts of jasmine flowers, 26-38 parts of scutellaria baicalensis, 33-50 parts of phellodendron, 46-73 parts of green tea, 60-90 parts of salvia miltiorrhiza, 49-78 parts of notoginseng powder, 28-40 parts of pearl powder and 30-45 parts of mint leaves.

[0006] Preferably, the following components are included by weight: 50-65 parts of Paris polyphylla, 15-20 parts of mulberry leaves, 20-25 parts of safflower, 30-35 parts of honeysuckle, 18-22 parts of jasmine flowers, 30-35 parts of scutellaria baicalensis, 35-45 parts of phellodendron amurense, 50-65 parts of green tea, 70-85 parts of salvia miltiorrhiza, 55-65 parts of notoginseng powder, 30-36 parts of pearl powder, and 35-45 parts of mint leaves.

[0007] Preferably, the following components are included by weight: 55 parts of Paris polyphylla, 18 parts of mulberry leaves, 22 parts of safflower, 32 parts of honeysuckle, 20 parts of jasmine flowers, 33 parts of scutellaria baicalensis, 33 parts of phellodendron amurense, 60 parts of green tea, 80 parts of salvia miltiorrhiza, 60 parts of notoginseng powder, 35 parts of pearl powder, and 40 parts of mint leaves.

[0008] Preferably, the weight ratio of Paris polyphylla to Carthamus tinctorius is 2-3:1-2.

[0009] Preferably, the weight ratio of Salvia miltiorrhiza to Phellodendron chinense is 1-3:1-3.

[0010] Preferably, the weight ratio of the pearl powder to the notoginseng powder is 1:1-2.

[0011] Preferably, the weight ratio of mulberry leaves to safflower is 1-2:1-2.

[0012] Preferably, the anti-acne Chinese medicine composition further comprises a pharmaceutically acceptable excipient.

[0013] Preferably, the dosage form of the acne-removing Chinese medicine composition is selected from powders, solutions, tinctures, lotions, ointments, oils, gels, coatings or liniments.

[0014] Preferably, the anti-acne Chinese medicine composition is prepared by the following steps:

[0015] (1) Pretreatment: grind 30-45 parts of Paris polyphylla, 15-25 parts of mulberry leaves, 15-25 parts of safflower, 26-38 parts of honeysuckle, 15-26 parts of jasmine flowers, 26-38 parts of scutellaria baicalensis, 33-50 parts of phellodendron amurense, 16-28 parts of green tea, 30-45 parts of salvia miltiorrhiza, and 30-45 parts of peppermint leaves into 10-30 meshes to obtain component A; grind the remaining Paris polyphylla, salvia miltiorrhiza, and green tea into 80-100 meshes to obtain component B;

[0016] (2) soaking component A, 33-50 parts of Panax notoginseng powder and 28-40 parts of pearl powder in 6-10 times the weight of double-distilled rice wine for three months, sealing the mixture and filtering to obtain extract A;

[0017] (3) Add component B and the remaining Panax notoginseng powder to the extract A, seal and soak for one month, filter, add 2-3 times the weight of the extract of pure water to the filtrate, shake well, and obtain the product.

[0018] Preferably, the degree of double-distilled rice wine is 40°-60°.

[0019] In certain embodiments, after soaking the above Chinese herbal medicine combination, the medicinal wine stock solution is purified, and 25-35 parts of pure water are added. The product only needs to be applied externally to the affected area to effectively dissolve the keratin of the hair follicles, causing acne and closed comedones to fall off automatically without damaging normal skin, thereby repairing acne scars. The product is also designed with a special roll-on bottle for sealed packaging, making it easy to apply and use.

[0020] The second purpose of the present invention relates to the use of the above-mentioned acne-removing Chinese medicine composition in the preparation of medicines for treating acne and acne skin diseases.

[0021] Preferably, the specific method of application is: the anti-acne Chinese herbal composition is used in a special roll-on bottle, and the anti-acne Chinese herbal composition is applied to the affected area, which can effectively dissolve the keratin of hair follicles, causing acne and closed comedones to fall off automatically without damaging normal skin, thereby repairing acne scars.

[0022] Compared with the prior art, the present invention has the following beneficial effects: (1) The external acne-removing composition obtained by quadruple compounding of Paris polyphylla and safflower, Salvia miltiorrhiza and Phellodendron amurense, pearl powder and Panax notoginseng powder, mulberry leaf and safflower can be applied to the affected area to effectively dissolve the keratin of the hair follicles, so that acne and closed comedones fall off automatically without damaging normal skin, and can repair acne scars, with an efficacy of more than 95%; (2) The raw materials in the present invention are all of natural plant origin, do not contain preservatives, additives, whitening agents and Western medicine ingredients, are non-irritating and non-allergic to the skin, are easy to use, have significant acne-removing and acne-treating effects, and have practical economic and clinical value; (3) It avoids the toxic and side effects caused by long-term oral administration of Chinese medicine by patients, has good safety, and is an innovation in the use of Chinese medicine for external acne removal; (4) It avoids the influence of daily phototherapy, electrotherapy and other physical therapies on patients' work and life, and has good compliance; (5) With the special ball-shaped bottle sealed packaging design, it is easy to apply and use. DETAILED DESCRIPTION

[0023] The following non-limiting examples can enable those skilled in the art to more fully understand the present invention, but do not limit the present invention in any way. The following content is merely an exemplary description of the scope of the present invention, and those skilled in the art can make various changes and modifications to the present invention based on the disclosed content, which should also fall within the scope of the present invention.

[0024] Embodiment 1:

[0025] The acne-removing Chinese medicine composition comprises the following raw material components by weight: 45 parts of Paris polyphylla, 15 parts of mulberry leaves, 15 parts of safflower, 26 parts of honeysuckle, 15 parts of jasmine flowers, 26 parts of scutellaria baicalensis, 33 parts of phellodendron amurense, 46 parts of green tea, 60 parts of salvia miltiorrhiza, 49 parts of notoginseng powder, 28 parts of pearl powder, and 30 parts of mint leaves.

[0026] The preparation process is as follows: (1) pretreatment: grind 30 parts of Paris polyphylla, 15 parts of mulberry leaves, 15 parts of safflower, 26 parts of honeysuckle, 15 parts of jasmine flowers, 26 parts of scutellaria baicalensis, 33 parts of phellodendron amurense, 16 parts of green tea, 30 parts of salvia miltiorrhiza, and 30 parts of peppermint leaves into 10 meshes to obtain component A; grind 15 parts of Paris polyphylla, 30 parts of salvia miltiorrhiza, and 30 parts of green tea into 80 meshes to obtain component B;

[0027] (2) Component A, 33 parts of Panax notoginseng powder and 28 parts of pearl powder were soaked and sealed in 8 times the weight of 50° double-distilled rice wine for three months, and then filtered to obtain extract A;

[0028] (3) Add component B and 16 parts of Panax notoginseng powder to extract A, seal and soak for one month, filter, add 2 times the weight of the extract to the filtrate, shake well, and obtain the product.

[0029] Embodiment 2:

[0030] The acne-removing Chinese medicine composition comprises the following raw material components by weight: 71 parts of Paris polyphylla, 25 parts of mulberry leaves, 25 parts of safflower, 38 parts of honeysuckle, 26 parts of jasmine flowers, 38 parts of scutellaria baicalensis, 50 parts of phellodendron amurense, 73 parts of green tea, 90 parts of salvia miltiorrhiza, 78 parts of notoginseng powder, 40 parts of pearl powder, and 45 parts of mint leaves.

[0031] The preparation process is as follows: (1) pretreatment: grind 45 parts of Paris polyphylla, 25 parts of mulberry leaves, 25 parts of safflower, 38 parts of honeysuckle, 26 parts of jasmine flowers, 38 parts of scutellaria baicalensis, 50 parts of phellodendron, 28 parts of green tea, 45 parts of salvia miltiorrhiza, and 45 parts of peppermint leaves into 30 meshes to obtain component A; grind 26 parts of Paris polyphylla, 45 parts of salvia miltiorrhiza, and 45 parts of green tea into 100 meshes to obtain component B;

[0032] (2) Component A, 50 parts of Panax notoginseng powder and 40 parts of pearl powder were soaked and sealed in 8 times the weight of 50° double-distilled rice wine for three months, and then filtered to obtain extract A;

[0033] (3) Add component B and 28 parts of Panax notoginseng powder to extract A, seal and soak for one month, filter, add 3 times the weight of the extract of purified water to the filtrate, shake well, and obtain the product.

[0034] Embodiment 3:

[0035] The acne-removing Chinese medicine composition comprises the following raw material components by weight: 55 parts of Paris polyphylla, 18 parts of mulberry leaves, 22 parts of safflower, 32 parts of honeysuckle, 20 parts of jasmine flowers, 33 parts of scutellaria baicalensis, 33 parts of phellodendron amurense, 60 parts of green tea, 80 parts of salvia miltiorrhiza, 60 parts of notoginseng powder, 35 parts of pearl powder, and 40 parts of mint leaves.

[0036] The preparation process is as follows: (1) pretreatment: grind 35 parts of Paris polyphylla, 18 parts of mulberry leaves, 22 parts of safflower, 32 parts of honeysuckle, 20 parts of jasmine flowers, 33 parts of scutellaria, 33 parts of phellodendron, 20 parts of green tea, 40 parts of salvia miltiorrhiza, and 40 parts of peppermint leaves into 20 meshes to obtain component A; grind 20 parts of Paris polyphylla, 40 parts of salvia miltiorrhiza, and 40 parts of green tea into 90 meshes to obtain component B;

[0037] (2) Component A, 40 parts of Panax notoginseng powder and 35 parts of pearl powder were soaked and sealed in 8 parts by weight of 50° double-distilled rice wine for three months, and then filtered to obtain extract A;

[0038] (3) Add component B and 20 parts of Panax notoginseng powder to extract A, seal and soak for one month, filter, add 3 times the weight of the extract of purified water to the filtrate, shake well, and obtain the product.

[0039] Comparative Example 1:

[0040] The acne-removing Chinese medicine composition comprises the following raw material components by weight: 77 parts of Paris polyphylla, 18 parts of mulberry leaves, 32 parts of honeysuckle, 20 parts of jasmine flowers, 33 parts of scutellaria baicalensis, 33 parts of phellodendron amurense, 60 parts of green tea, 80 parts of salvia miltiorrhiza, 60 parts of notoginseng powder, 35 parts of pearl powder, and 40 parts of mint leaves.

[0041] The preparation process is as follows: (1) pretreatment: grind 49 parts of Paris polyphylla, 18 parts of mulberry leaves, 32 parts of honeysuckle, 20 parts of jasmine flowers, 33 parts of scutellaria baicalensis, 33 parts of phellodendron amurense, 20 parts of green tea, 40 parts of salvia miltiorrhiza, and 40 parts of peppermint leaves into 20 meshes to obtain component A; grind 28 parts of Paris polyphylla, 40 parts of salvia miltiorrhiza, and 40 parts of green tea into 90 meshes to obtain component B;

[0042] (2) Component A, 40 parts of Panax notoginseng powder and 35 parts of pearl powder were soaked and sealed in 8 parts by weight of 50° double-distilled rice wine for three months, and then filtered to obtain extract A;

[0043] (3) Add component B and 20 parts of Panax notoginseng powder to extract A, seal and soak for one month, filter, add 3 times the weight of the extract of purified water to the filtrate, shake well, and obtain the product.

[0044] Comparative Example 2:

[0045] The acne-removing Chinese medicine composition comprises the following raw material components by weight: 18 parts of mulberry leaves, 77 parts of safflower, 32 parts of honeysuckle, 20 parts of jasmine flowers, 33 parts of scutellaria baicalensis, 33 parts of phellodendron chinense, 60 parts of green tea, 80 parts of salvia miltiorrhiza, 60 parts of notoginseng powder, 35 parts of pearl powder, and 40 parts of mint leaves.

[0046] The preparation process is as follows: (1) pretreatment: 18 parts of mulberry leaves, 77 parts of safflower, 32 parts of honeysuckle, 20 parts of jasmine flowers, 33 parts of scutellaria, 33 parts of phellodendron, 20 parts of green tea, 40 parts of salvia miltiorrhiza, and 40 parts of mint leaves are crushed into 20 meshes to obtain component A; 40 parts of salvia miltiorrhiza and 40 parts of green tea are crushed into 90 meshes to obtain component B;

[0047] (2) Component A, 40 parts of Panax notoginseng powder and 35 parts of pearl powder were soaked and sealed in 8 parts by weight of 50° double-distilled rice wine for three months, and then filtered to obtain extract A;

[0048] (3) Add component B and 20 parts of Panax notoginseng powder to extract A, seal and soak for one month, filter, add 3 times the weight of the extract of purified water to the filtrate, shake well, and obtain the product.

[0049] Comparative Example 3:

[0050] The acne-removing Chinese medicine composition comprises the following raw material components by weight: 55 parts of Paris polyphylla, 40 parts of safflower, 32 parts of honeysuckle, 20 parts of jasmine flowers, 33 parts of scutellaria baicalensis, 33 parts of phellodendron amurense, 60 parts of green tea, 80 parts of salvia miltiorrhiza, 60 parts of notoginseng powder, 35 parts of pearl powder, and 40 parts of mint leaves.

[0051] The preparation process is as follows: (1) pretreatment: grind 35 parts of Paris polyphylla, 40 parts of safflower, 32 parts of honeysuckle, 20 parts of jasmine flower, 33 parts of scutellaria, 33 parts of phellodendron, 20 parts of green tea, 40 parts of salvia miltiorrhiza, and 40 parts of peppermint leaves into 20 meshes to obtain component A; grind 20 parts of Paris polyphylla, 40 parts of salvia miltiorrhiza, and 40 parts of green tea into 90 meshes to obtain component B;

[0052] (2) Component A, 40 parts of Panax notoginseng powder and 35 parts of pearl powder were soaked and sealed in 8 parts by weight of 50° double-distilled rice wine for three months, and then filtered to obtain extract A;

[0053] (3) Add component B and 20 parts of Panax notoginseng powder to extract A, seal and soak for one month, filter, add 3 times the weight of the extract of purified water to the filtrate, shake well, and obtain the product.

[0054] Comparative Example 4:

[0055] The acne-removing Chinese medicine composition comprises the following raw material components by weight: 55 parts of Paris polyphylla, 40 parts of mulberry leaves, 32 parts of honeysuckle, 20 parts of Jasmine flowers, 33 parts of Scutellaria baicalensis, 33 parts of Phellodendron amurense, 60 parts of green tea, 80 parts of Salvia miltiorrhiza, 60 parts of Panax notoginseng powder, 35 parts of pearl powder, and 40 parts of mint leaves.

[0056] The preparation process is as follows: (1) pretreatment: grind 35 parts of Paris polyphylla, 40 parts of mulberry leaves, 32 parts of honeysuckle, 20 parts of jasmine flowers, 33 parts of scutellaria baicalensis, 33 parts of phellodendron amurense, 20 parts of green tea, 40 parts of salvia miltiorrhiza, and 40 parts of peppermint leaves into 20 meshes to obtain component A; grind 20 parts of Paris polyphylla, 40 parts of salvia miltiorrhiza, and 40 parts of green tea into 90 meshes to obtain component B;

[0057] (2) Component A, 40 parts of Panax notoginseng powder and 35 parts of pearl powder were soaked and sealed in 8 parts by weight of 50° double-distilled rice wine for three months, and then filtered to obtain extract A;

[0058] (3) Add component B and 20 parts of Panax notoginseng powder to extract A, seal and soak for one month, filter, add 3 times the weight of the extract of purified water to the filtrate, shake well, and obtain the product.

[0059] Comparative Example 5:

[0060] The acne-removing Chinese medicine composition comprises the following raw material components by weight: 55 parts of Paris polyphylla, 18 parts of mulberry leaves, 22 parts of safflower, 32 parts of honeysuckle, 20 parts of jasmine flowers, 33 parts of scutellaria baicalensis, 33 parts of phellodendron amurense, 60 parts of green tea, 80 parts of salvia miltiorrhiza, 95 parts of Panax notoginseng powder, and 40 parts of mint leaves.

[0061] The preparation process is as follows: (1) pretreatment: grind 35 parts of Paris polyphylla, 18 parts of mulberry leaves, 22 parts of safflower, 32 parts of honeysuckle, 20 parts of jasmine flowers, 33 parts of scutellaria, 33 parts of phellodendron, 20 parts of green tea, 40 parts of salvia miltiorrhiza, and 40 parts of peppermint leaves into 20 meshes to obtain component A; grind 20 parts of Paris polyphylla, 40 parts of salvia miltiorrhiza, and 40 parts of green tea into 90 meshes to obtain component B;

[0062] (2) Component A and 63.3 parts of Panax notoginseng powder were soaked in 8 parts by weight of 50° double-distilled rice wine, sealed for three months, and filtered to obtain extract A;

[0063] (3) Add component B and 31.7 parts of Panax notoginseng powder to extract A, seal and soak for one month, filter, add 3 times the weight of the extract in purified water to the filtrate, shake well, and obtain the product.

[0064] Comparative Example 6:

[0065] The acne-removing Chinese medicinal composition comprises the following raw material components by weight: 55 parts of Paris polyphylla, 18 parts of mulberry leaves, 22 parts of safflower, 32 parts of honeysuckle, 20 parts of jasmine flowers, 33 parts of scutellaria baicalensis, 33 parts of phellodendron amurense, 60 parts of green tea, 80 parts of salvia miltiorrhiza, 95 parts of pearl powder and 40 parts of mint leaves.

[0066] The preparation process is as follows: (1) pretreatment: grind 35 parts of Paris polyphylla, 18 parts of mulberry leaves, 22 parts of safflower, 32 parts of honeysuckle, 20 parts of jasmine flowers, 33 parts of scutellaria, 33 parts of phellodendron, 20 parts of green tea, 40 parts of salvia miltiorrhiza, and 40 parts of peppermint leaves into 20 meshes to obtain component A; grind 20 parts of Paris polyphylla, 40 parts of salvia miltiorrhiza, and 40 parts of green tea into 90 meshes to obtain component B;

[0067] (2) soaking component A and 95 parts of pearl powder in 8 parts by weight of 50° double-distilled rice wine, sealing the mixture for three months, and filtering the mixture to obtain extract A;

[0068] (3) Add component B to extract A, seal and soak for one month, filter, add 3 times the weight of the extract in purified water to the filtrate, shake well, and obtain the product.

[0069] Test Example 1:

[0070] Treatment effect on acne

[0071] 1. Case selection criteria

[0072] The clinical manifestations of acne are papules, pustules, nodules, cysts and scars on the face, accompanied by greasy facial skin. Those with the above symptoms are selected as cases.

[0073] 2. Diagnostic criteria: Anyone with papules, pustules, nodules, cysts and scars on the face, accompanied by oily facial skin, can be diagnosed as an acne patient.

[0074] 3. Treatment options

[0075] The compositions of the above-mentioned Examples 1-3 and Comparative Examples 1-6 were placed in a roll-on bottle. Patients diagnosed with acne were treated with the preparations of Examples 1-3 and Comparative Examples 1-6 of the present invention. After cleaning the affected area with warm water, the composition of the present invention was applied to the affected area, left for 30 minutes and then washed off. The composition was used once in the morning and evening every day, and the efficacy was statistically analyzed for 3 months.

[0076] 4. Efficacy evaluation criteria

[0077] A. Developed based on the "Guidelines for Clinical Research of New Chinese Medicines for the Treatment of Acne Vulgaris·Efficacy Determination Criteria" published by China Medical Science and Technology Press in 2002.

[0078] Cure: Skin lesion regression rate ≥ 95%, only pigmentation remains, and no new lesions appear;

[0079] Effective: Skin lesion regression rate ≥50%, new lesions still appear;

[0080] Ineffective: Skin lesion regression rate is less than 50%, the skin lesions are not reduced enough, or even increase.

[0081] B. Pillsburg grading system is divided into 4 grades according to the degree of inflammatory lesions and deep lesions:

[0082] Grade Ⅰ (mild), the main skin lesions are blackheads, scattered or multiple. Inflammatory papules are scattered. The total number of lesions is 10-30;

[0083] Grade II (moderate): the main skin lesions are comedones, with a moderate number of papules and potential pustules, with a total number of 31-50 lesions, limited to the face;

[0084] Grade III (severe): the main skin lesions are deep inflammatory papules and pustules, with a total number of 51-100 lesions and less than 3 nodules, occurring on the face, neck, chest and back;

[0085] Grade IV (severe-clustered): the main skin lesions are deep inflammatory papules and pustules, with a total number of more than 100 lesions, more than 3 nodules or cysts, easy to form scars, and occur on the upper body;

[0086] 5. Statistical analysis

[0087] According to the above-mentioned efficacy evaluation standard A, after each group of patients used the composition of the present invention for 90 days, the statistical results are shown in Table 1.

[0088] Table 1: Effect data of Examples 1-3 and Comparative Examples 1-6 of the present invention

[0089]

[0090] According to the above experimental results, the effective rates of the compounds in Examples 1-3 of the present invention on acne are all above 95%, which are significantly higher than those in Comparative Examples 1-6.

[0091] According to the above classification method B, the number of patients in each group is shown in Table 2. The statistical results are shown in Table 3 after 90 days of using the composition of the present invention on the confirmed patients.

[0092] Table 2: Number of patients in each group at different levels

[0093]

[0094] The composition of the present invention was used on the confirmed patients, and after 90 days, the statistical results were as follows:

[0095] Table 3: Statistics of treatment effects in each group

[0096]

[0097] Note: Comparison of skin lesion index before and after treatment at each level with that before treatment, *P<0.05, **P<0.01.

[0098] During the treatment process of all patients, no adverse reactions were found when using the composition, indicating that the composition is safe to use, has good compliance, and has stable and reliable efficacy.

[0099] Typical Cases

[0100] (1) Duan, female, 18 years old, student, had many acne on her face for half a year, with flushed skin, dense blackheads and cysts, especially on the forehead and cheeks. She had tried various methods for treatment, but the results were not satisfactory and the acne recurred repeatedly. After using the composition of Example 3 of the present invention for one month, the facial acne cysts and inflammation subsided, the blackheads disappeared, and only pigmentation remained on the skin. After continuing to use it for two months, the recurring acne was completely cured. No recurrence was found after one year of follow-up.

[0101] (2) Zhang, male, 23 years old, office worker, had acne on his face for more than three years. His face was shiny and oily, his hair follicles were dilated, seborrhea was obvious, accompanied by nodules, and multiple lesions were also seen on his neck, chest, and back. After using the composition of Example 2 of the present invention for one month, he felt that his face was less oily, the acne subsided, and the nodules were reduced. After continuing to use it for two months, he was cured. No recurrence was found during the six-month follow-up.

[0102] Finally, it should be noted that the above content is only used to illustrate the technical solution of the present invention, rather than to limit the scope of protection of the present invention. Simple modifications or equivalent substitutions of the technical solution of the present invention by ordinary technicians in this field do not deviate from the essence and scope of the technical solution of the present invention.

Claims

1. An anti-acne Chinese medicine composition, characterized in that: The acne-removing Chinese medicine composition is prepared from the following raw materials by weight: 45-71 parts of Paris polyphylla, 15-25 parts of mulberry leaves, 15-25 parts of safflower, 26-38 parts of honeysuckle, 15-26 parts of frangipani, 26-38 parts of scutellaria, 33-50 parts of phellodendron, 46-73 parts of green tea, 60-90 parts of salvia miltiorrhiza, 49-78 parts of notoginseng powder, 28-40 parts of pearl powder, and 30-45 parts of mint leaves; wherein The weight ratio of Paris polyphylla to Carthamus tinctorius is 2-3:1-2; The weight ratio of Danshen to Phellodendron chinense is 1-3:1-3; The weight ratio of the pearl powder to the notoginseng powder is 1:1-2; The weight ratio of the mulberry leaves to the safflower is 1-2:1-2.

2. The acne-removing Chinese medicinal composition according to claim 1, characterized in that: The acne-removing Chinese medicinal composition is prepared from the following raw materials by weight: 50-65 parts of Paris polyphylla, 15-20 parts of mulberry leaves, 20-25 parts of safflower, 30-35 parts of honeysuckle, 18-22 parts of jasmine flowers, 30-35 parts of scutellaria baicalensis, 35-45 parts of phellodendron amurense, 50-65 parts of green tea, 70-85 parts of salvia miltiorrhiza, 55-65 parts of notoginseng powder, 30-36 parts of pearl powder and 35-45 parts of mint leaves.

3. The acne-removing Chinese medicine composition according to claim 1, characterized in that: The acne-removing Chinese medicine composition is prepared from the following raw materials by weight: 55 parts of Paris polyphylla, 18 parts of mulberry leaves, 22 parts of safflower, 32 parts of honeysuckle, 20 parts of jasmine flowers, 33 parts of scutellaria baicalensis, 33 parts of phellodendron amurense, 60 parts of green tea, 80 parts of salvia miltiorrhiza, 60 parts of notoginseng powder, 35 parts of pearl powder, and 40 parts of mint leaves.

4. The acne-removing Chinese medicinal composition according to any one of claims 1 to 3, characterized in that: The acne-removing Chinese medicinal composition also includes pharmaceutically acceptable excipients.

5. The acne-removing Chinese medicinal composition according to claim 1, characterized in that: The anti-acne Chinese medicine composition is prepared by the following steps: (1) Pretreatment: grind 30-45 parts of Paris polyphylla, 15-25 parts of mulberry leaves, 15-25 parts of safflower, 26-38 parts of honeysuckle, 15-26 parts of jasmine flowers, 26-38 parts of scutellaria baicalensis, 33-50 parts of phellodendron amurense, 16-28 parts of green tea, 30-45 parts of salvia miltiorrhiza, and 30-45 parts of peppermint leaves into 10-30 meshes to obtain component A; grind the remaining Paris polyphylla, salvia miltiorrhiza, and green tea into 80-100 meshes to obtain component B; (2) soaking component A, 33-50 parts of Panax notoginseng powder and 28-40 parts of pearl powder in 6-10 times the weight of double-distilled rice wine for three months, sealing the mixture and filtering to obtain extract A; (3) Add component B and the remaining Panax notoginseng powder to the extract A, seal and soak for one month, filter, add 2-3 times the weight of the extract of pure water to the filtrate, shake well, and obtain the product.

6. Use of the anti-acne Chinese medicinal composition according to any one of claims 1 to 5 in the preparation of a drug for treating acne.

Images