A decolorization device with dynamic temperature regulation and its application in raw material drug production

Abstract

The invention relates to the technical field of raw material decolorization, and in particular to a decolorization device with dynamic temperature regulation and application thereof in raw material medicine production; the device comprises: a base frame; a decolorization module, wherein the decolorization module is fixedly arranged on the base frame in a vertical state; the decolorization module is provided with a plurality of decolorization cylinders capable of providing different decolorization temperatures and the plurality of decolorization cylinders are sequentially connected and arranged; a stirring module, wherein the stirring module is rotatably arranged in the decolorization module; the stirring module is provided with a stirring shaft and a stirring unit coaxially fixedly arranged outside the stirring shaft and a sealing unit capable of continuously blocking a conduction channel between two adjacent decolorization cylinders; a dynamic heating module is coaxially fixedly arranged outside the decolorization module; the device can not only efficiently adsorb pigments in a medicinal solution but also flexibly regulate the heating temperature of the medicinal solution according to decolorization requirements during the decolorization process.

Description

Technical Field

[0001] The invention relates to the technical field of raw material decolorization, and in particular to a decolorization device with dynamic temperature regulation and application thereof in raw material medicine production. Background Art

[0002] In the production process of APIs, decolorization is an essential process, especially in the production of fine chemicals, food additives and pharmaceutical APIs. Its purpose is to remove pigments, impurities and by-products in the product, thereby improving the purity and appearance quality of the product. At present, the commonly used decolorization methods mostly use adsorbents (such as activated carbon) to separate pigments and impurities, usually combined with heating to enhance the adsorption effect. However, in this type of method, different types of APIs have great differences in their tolerance to temperature. If there is a lack of precise temperature control during the decolorization process, excessively high temperatures can easily lead to degradation or inactivation of heat-sensitive components, ultimately resulting in a decline in product quality and even affecting production output.

[0003] For example, the Chinese patent CN216497607U applies for an activated carbon decolorization device for the synthesis of pharmaceutical intermediates. The device continuously adjusts the position of the sleeve containing activated carbon so that the liquid medicine is in continuous contact with the activated carbon during the stirring process to achieve the purpose of decolorization. Although this device can achieve a certain degree of pigment adsorption, it has many limitations. For example, at room temperature, the adsorption speed is slow, especially for macromolecular pigments. In addition, since the activated carbon is fixed in the sleeve, its contact area is limited, and the device needs to frequently drive the sleeve to enhance the adsorption effect, resulting in a long decolorization cycle.

[0004] In order to improve the decolorization efficiency, some equipment will also use a fixed temperature heating method for the drug solution, but this method lacks flexibility and is difficult to adapt to different production stages or changes in the characteristics of the API. Heating at a fixed temperature is not only difficult to achieve real-time temperature control, but may also cause uneven decolorization and even cause changes in the chemical properties of the API, affecting the stability of product quality. Furthermore, long-term high-temperature treatment will cause the adsorbent to gradually lose its adsorption capacity, resulting in an increase in the frequency of replacement, which in turn increases production costs and increases the complexity of equipment maintenance. Summary of the invention

[0005] In view of the above problems, a decolorization equipment with dynamic temperature control is provided. By proposing a device that can not only efficiently adsorb drugs but also realize the flexible conversion of drugs at different temperatures in different decolorization stages, the technical problems that the existing decolorization equipment has large limitations, cannot fully adsorb the pigments in the drug solution and cannot realize flexible temperature control in the heating-assisted decolorization stage are solved.

[0006] In order to solve the problems of the prior art, the present invention provides a decolorization device with dynamic temperature control, characterized in that it includes: a base frame; a decolorization module, which is fixedly arranged on the base frame in a vertical state; the decolorization module is provided with a plurality of decolorization cylinders that can provide different decolorization temperatures and the plurality of decolorization cylinders are connected in sequence; a stirring module, which is rotatably arranged in the decolorization module, and is used to stir the liquid in the decolorization module; the stirring module is provided with a stirring shaft and a stirring unit coaxially fixedly arranged outside the stirring shaft and a sealing unit capable of continuously blocking the conduction channel between two adjacent groups of decolorization cylinders; the stirring unit and the sealing unit are both provided in multiple groups and are arranged one by one with the plurality of groups of decolorization cylinders; a filtering module is detachably arranged at the stirring end of the stirring module; and a dynamic heating module is coaxially fixedly arranged outside the decolorization module.

[0007] Preferably, the decolorization module also includes a conduction bin capable of connecting multiple groups of decolorization cylinders in series, wherein the multiple groups of decolorization cylinders are respectively an upper decolorization cylinder, a middle decolorization cylinder and a lower decolorization cylinder; the feed port and the discharge port of the conduction bin are respectively connected to the liquid outlet and the liquid inlet of the adjacent upper and lower decolorization cylinders; and heat insulation layers are respectively provided between the upper decolorization cylinder, the middle decolorization cylinder and the lower decolorization cylinder, and the heat insulation layers are used to block the conduction of heat energy between adjacent decolorization cylinders.

[0008] Preferably, the stirring module also includes a driving rod, a rotating driving element and a lifting element; the driving rod is coaxially slidably arranged in the stirring shaft; the stirring shaft is a hollow cylindrical rod body with openings at both ends and the side wall is also radially provided with an oblong through hole; the rotating driving element is vertically fixed on the top of the decolorization module through a first mounting frame and is transmission-connected to the driving end of the stirring shaft; the lifting element is vertically fixed on one side of the decolorization module, and the lifting end is fixedly connected to the top of the driving rod through a connecting frame.

[0009] Preferably, the stirring unit includes a guiding element, a stirring portion and a traction element; the guiding element is coaxially fixedly arranged outside the stirring shaft; the stirring portion is slidably arranged at the guiding end of the guiding element and can slide back and forth along the guiding direction of the guiding element; the filtering module is detachably arranged on the stirring portion; the traction element is horizontally fixedly arranged on one side of the guiding element, and one end of the traction element is fixedly connected to the guiding element and the other end is fixedly connected to the stirring portion; the traction element is used to continuously pull the stirring portion close to the stirring shaft.

[0010] Preferably, the stirring part is composed of a sliding member and a rectangular frame vertically arranged under the sliding member; the top surface of the rectangular frame is also provided with a receiving groove for storing activated carbon and a slot penetrating through one side of the rectangular frame.

[0011] Preferably, the stirring module also includes a third guide rod and a scraper capable of sliding back and forth along the long side of the rectangular frame. The third guide rod is vertically fixed to one side of the driving rod and the rod portion of the third guide rod is slidably matched with the scraper. The third guide rod is used to guide and drive the scraper to move.

[0012] Preferably, the sealing unit includes a sealing plate, a rotating frame, a spring, a fixed plate and a one-way driving element; a sealing plate, wherein the sealing plate is coaxially rotatably arranged outside the stirring shaft through the rotating frame, and the sealing plate is arranged in multiple groups along the circumferential direction of the axis of the rotating frame; a fixed plate, wherein the fixed plate is vertically arranged on the rotating frame and is arranged close to the edge of the rotating frame; a one-way driving element, wherein the one-way driving element is coaxially fixedly arranged outside the stirring shaft and is located above the rotating frame; a spring, wherein the spring is coaxially fixedly arranged outside the stirring shaft, and both ends of the spring are respectively abutted against adjacent surfaces of the rotating frame and the one-way driving element; wherein the one-way driving element is provided with a driving plate that can be flipped one-way.

[0013] Preferably, the filter module is a stainless steel screen.

[0014] Preferably, the dynamic heating module includes an outer guide cylinder, a heating module and a linear drive; the outer guide cylinder is coaxially fixed outside the decolorization module; the heating module is coaxially slidably arranged inside the outer guide cylinder; and the linear drive is vertically fixed on one side of the outer guide cylinder and the driving end is fixedly connected to the heating module.

[0015] The invention discloses an application of a decolorizing device with dynamic temperature adjustment in the production of raw materials, which is applied to a decolorizing device with dynamic temperature adjustment, and comprises the following steps:

[0016] S1: dissolve the drug to be decolorized in a solvent, add an appropriate amount of activated carbon and stir to ensure full dissolution, so as to form a uniform drug solution; then pour the drug solution into the upper decolorization cylinder, immediately connect the power supply and start the rotary drive element, so that the stirring shaft drives the stirring unit to rotate, and fully stir the drug solution in the upper decolorization cylinder;

[0017] S2: While the liquid medicine is being decolorized, the dynamic heating module heats the upper decolorization cylinder, thereby increasing the liquid medicine temperature in the upper decolorization cylinder to improve the adsorption capacity of the activated carbon, so that the pigment in the liquid medicine is efficiently adsorbed by the activated carbon under heating and stirring;

[0018] S3: When the liquid medicine in the upper decolorization cylinder reaches the expected decolorization effect, the sealing unit is adjusted by controlling the reverse movement of the stirring shaft, thereby opening the conduction channel of the conduction chamber, so that the liquid medicine automatically flows into the middle decolorization cylinder or the lower decolorization cylinder; in this process, the heat insulation layer is used to avoid heat conduction, ensuring that the temperature in each decolorization cylinder is independently controlled; the dynamic heating module then heats the liquid medicine in the middle decolorization cylinder or the lower decolorization cylinder, so that it continues to decolorize under the new temperature environment;

[0019] S4: After the decolorization is completed, the driving rod is driven by the lifting element to move, driving the scraper to scrape the activated carbon adsorbed on the surface of the filter module from bottom to top into the containing tank, so as to separate the solid and liquid, remove most of the activated carbon in the liquid medicine, and finally open the discharge port of the lower decolorization cylinder to discharge the liquid medicine.

[0020] Compared with the prior art, the present invention has the following beneficial effects:

[0021] 1. Compared with the traditional equipment that uses only a single temperature for decolorization, the present invention introduces a multi-stage heating structure, which can flexibly conduct the liquid medicine between the upper decolorization cylinder, the middle decolorization cylinder or the lower decolorization cylinder; it realizes the treatment of the liquid medicine in different temperature environments, making the decolorization process more flexible, and can accurately adjust the temperature according to actual needs, avoiding the degradation or inactivation of heat-sensitive components caused by high temperature;

[0022] 2. The present invention adopts an independent heating module, which can heat different decolorization cylinders separately, thereby ensuring the efficient adsorption capacity of activated carbon; through this segmented heating and dynamic temperature adjustment, the liquid medicine can better remove impurities and pigments during the decolorization process, enhance the decolorization effect, and improve the product purity;

[0023] 3. The present invention improves the adsorption effect of activated carbon while uniformly stirring the drug solution through the coordination of the stirring module and the filtering module, and realizes the separate collection of activated carbon by cooperating with the scraper after decolorization, which greatly reduces the subsequent filtering cycle of activated carbon, realizes the effect of efficient decolorization of the drug solution and effective control of activated carbon at the same time. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 It is a three-dimensional diagram of a decolorization device with dynamic temperature adjustment;

[0025] Figure 2 It is a side view of a decolorization device with dynamic temperature adjustment;

[0026] Figure 3 yes Figure 2 A cross-sectional view at AA of FIG.

[0027] Figure 4 yes Figure 3 A partial enlarged view of point B;

[0028] Figure 5 It is a top view of a decolorization device with dynamic temperature adjustment;

[0029] Figure 6 yes Figure 5 A three-dimensional cross-sectional view of the section at CC;

[0030] Figure 7 yes Figure 6 A partial enlarged view of point D;

[0031] Figure 8 yes Figure 6 A local enlarged view of point E;

[0032] Fig. 9 It is a partially exploded three-dimensional diagram of the structure of a dynamic temperature-adjusting decolorization device without a base frame and a dynamic heating module;

[0033] Fig.10 yes Fig. 9 A partial enlarged view of point F.

[0034] The numbers in the figure are: 1, base frame; 2, decolorization module; 21, decolorization cylinder; 211, upper decolorization cylinder; 212, middle decolorization cylinder; 213, lower decolorization cylinder; 22, conduction chamber; 23, heat insulation layer; 3, stirring module; 31, stirring shaft; 32, stirring unit; 321, guiding element; 322, stirring part; 3221, sliding member; 3222, rectangular frame; 3223, containing groove; 3224, slot; 323, pulling element; 33, sealing unit; 331, sealing plate; 332, rotating frame; 33 3. Spring; 334. Fixed plate; 335. One-way driving element; 3351. Driving plate; 3352. Fixed ring; 3353. Rotating ring; 3354. Limiting plate; 3355. Torsion spring; 34. Driving rod; 341. Oblong through hole; 35. Rotating driving element; 36. Lifting element; 37. Third guide rod; 38. Scraper; 39. Guide frame; 4. Filter module; 41. Stainless steel screen; 5. Dynamic heating module; 51. External guide cylinder; 52. Heating module; 53. Linear drive. DETAILED DESCRIPTION

[0035] In order to further understand the features, technical means, specific objectives and functions of the present invention, the present invention is further described in detail below in conjunction with the accompanying drawings and specific implementation methods.

[0036] See also Figures 1 to 10As shown: a decolorization device with dynamic temperature adjustment, comprising: a base frame 1; a decolorization module 2, the decolorization module 2 is fixedly arranged on the base frame 1 in a vertical state; the decolorization module 2 is provided with a plurality of decolorization cylinders 21 that can provide different decolorization temperatures and the plurality of decolorization cylinders 21 are connected in sequence; a stirring module 3, the stirring module 3 is rotatably arranged in the decolorization module 2, and the stirring module 3 is used to stir the liquid in the decolorization module 2; the stirring module 3 is provided with a stirring shaft 31 and a stirring unit 32 coaxially fixedly arranged outside the stirring shaft 31 and a sealing unit 33 that can continuously block the conduction channel between two adjacent decolorization cylinders 21; the stirring unit 32 and the sealing unit 33 are both provided with a plurality of groups and are arranged one by one with the plurality of decolorization cylinders 21; the filtering module 4 is detachably arranged at the stirring end of the stirring module 3; the dynamic heating module 5 is coaxially fixedly arranged outside the decolorization module 2.

[0037] In a non-working state, the sealing unit 33 is always in close contact with the inner wall of the decolorizing cylinder 21, thereby effectively blocking the conduction channel between two adjacent decolorizing cylinders 21 to prevent the liquid medicine from leaking or conducting prematurely under unexpected circumstances.

[0038] When drug decolorization is required, the drug or compound is first dissolved in a suitable solvent, such as water or an organic solvent, and an appropriate amount of activated carbon is added for full stirring to ensure that the drug is completely dissolved and a uniform liquid is formed and mixed with the activated carbon. Subsequently, the liquid medicine is injected into the decolorization cylinder 21 at the top of the decolorization module 2. After the liquid medicine enters the decolorization cylinder 21, the stirring module 3 is driven to act, the stirring shaft 31 is driven to rotate, and then the stirring unit 32 and the filtering module 4 are driven to rotate clockwise to achieve the coordinated treatment of liquid medicine stirring and pigment adsorption. At this time, the dynamic heating module 5 heats the decolorization cylinder 21 synchronously, so that the liquid medicine is heated to a preset temperature, thereby enhancing the adsorption efficiency of the activated carbon, until the pigment in the liquid medicine is fully adsorbed. The liquid medicine introduced into the decolorization cylinder 21 each time is 80% of the volume of the decolorization cylinder 21.

[0039] When the heating environment of the liquid medicine needs to be changed to continue the treatment, the stirring shaft 31 is driven counterclockwise, and the stirring unit 32 drives the sealing unit 33 to move, thereby opening the conduction channel between the adjacent decolorizing cylinders 21. At this time, the liquid medicine in the top decolorizing cylinder 21 automatically flows into the decolorizing cylinder 21 with different temperature arranged below under the action of gravity, realizing the operation of quickly changing the decolorizing temperature and optimizing the overall decolorizing process.

[0040] Through the series structure of the dynamic heating module 5 and multiple groups of decolorization cylinders 21, combined with the controllable opening of the sealing unit 33, the temperature conversion during the decolorization process is faster and more flexible, thereby improving the decolorization efficiency while maintaining the purity of the drug solution and the chemical stability of the drug, effectively avoiding the problems of uniformity and insufficient adsorption efficiency under fixed temperature treatment.

[0041] See also Figure 3 and Figure 4 As shown: the decolorization module 2 also includes a conduction bin 22 capable of connecting multiple groups of decolorization cylinders 21 in series, wherein the multiple groups of decolorization cylinders 21 are respectively an upper decolorization cylinder 211, a middle decolorization cylinder 212 and a lower decolorization cylinder 213; the feed inlet and the discharge outlet of the conduction bin 22 are respectively connected to the liquid outlet and the liquid inlet of the adjacent upper and lower decolorization cylinders; and heat insulation layers 23 are respectively provided between the upper decolorization cylinder 211, the middle decolorization cylinder 212 and the lower decolorization cylinder 213, and the heat insulation layers 23 are used to block the heat energy conduction between adjacent decolorization cylinders 21.

[0042] By using the conduction chamber 22 to connect the upper decolorization cylinder 211, the middle decolorization cylinder 212 and the lower decolorization cylinder 213 in series, and arranging a heat insulation layer 23 that can effectively isolate heat therebetween, not only the orderly connection between the upper decolorization cylinder 211, the middle decolorization cylinder 212 and the lower decolorization cylinder 213 is achieved, but also each decolorization cylinder 21 is effectively separated independently to prevent heat from being conducted between the decolorization cylinders 21. Such a design avoids temperature instability caused by heat conduction, ensures that each decolorization cylinder 21 can maintain a preset heating temperature, and thus achieves precise decolorization treatment under different temperature conditions. The conduction space formed inside the conduction chamber 22 constitutes a conduction channel for the transmission of the liquid medicine between the decolorization cylinders 21, ensuring the smooth conduction of the liquid medicine.

[0043] By providing a heat insulating layer 23 between the upper decolorizing cylinder 211, the middle decolorizing cylinder 212 and the lower decolorizing cylinder 213, the problem of temperature interference is effectively avoided, so that each decolorizing cylinder 21 maintains an independent heating environment. This not only improves the decolorizing efficiency and effect, but also ensures that the liquid medicine can be processed stably and evenly in different decolorizing cylinders 21, thereby avoiding the problem of unstable decolorizing quality caused by uneven temperature, and improving the stability and controllability of the overall production process.

[0044] See also Figure 3 and Figure 7 As shown: the stirring module 3 also includes a driving rod 34, a rotating driving element 35 and a lifting element 36; the driving rod 34, the driving rod 34 is coaxially slidably arranged in the stirring shaft 31; the stirring shaft 31, the stirring shaft 31 is a hollow cylindrical rod body with openings at both ends and the side wall is also radially provided with an oblong through hole 341; the rotating driving element 35 is vertically fixedly arranged on the top of the decolorization module 2 through a first mounting frame and is transmission-connected to the driving end of the stirring shaft 31; the lifting element 36 is vertically fixedly arranged on one side of the decolorization module 2, and the lifting end is fixedly connected to the top of the driving rod 34 through a connecting frame.

[0045] When it is necessary to drive the stirring shaft 31 to rotate so as to synchronously drive the stirring unit 32 to stir the liquid medicine in the upper decolorizing cylinder 211, firstly connect the external power supply to start the rotating driving element 35. The rotating driving element 35 drives the stirring shaft 31 to rotate by rotating its output shaft, thereby driving the stirring shaft 31 and the stirring unit 32 to rotate synchronously in turn. Through this rotating action, it is ensured that the liquid medicine in the upper decolorizing cylinder 211 is fully stirred, so that the pigment in the liquid medicine can fully contact with the activated carbon and be effectively adsorbed, thereby improving the decolorization efficiency.

[0046] The rotary drive element 35 is composed of a servo motor, a driving wheel coaxially fixedly mounted on the driving shaft of the servo motor, and a driven wheel coaxially fixedly mounted on the transmission end of the stirring shaft 31. The servo motor is vertically fixedly mounted on the top of the decolorization module 2 through a first mounting frame to ensure stable driving performance and operating accuracy.

[0047] The synchronous driving of the stirring shaft 31 and the stirring unit 32 can ensure efficient and uniform stirring of the liquid medicine in the upper decolorizing cylinder 211. Combined with the adsorption effect of activated carbon, the adsorption efficiency of the decolorization process and the purity of the liquid medicine are improved, and the problem of pigment residue or incomplete decolorization caused by uneven stirring is avoided, thereby significantly enhancing the overall effect and stability of the decolorization process.

[0048] The lifting element 36 is composed of an electric push rod, a rotating ring and a connecting frame; the connecting frame is rotatably connected to the top of the driving rod 34 through the rotating ring, and the other end of the connecting frame is fixedly connected to the driving end of the electric push rod. When the driving rod 34 needs to be driven axially, it is only necessary to connect an external power supply to drive the output shaft of the electric push rod to extend.

[0049] See also Figure 7 and Fig. 9 As shown: the stirring unit 32 includes a guiding element 321, a stirring portion 322 and a pulling element 323; the guiding element 321, the guiding element 321 is coaxially fixedly arranged outside the stirring shaft 31; the stirring portion 322, the stirring portion 322 is slidably arranged at the guiding end of the guiding element 321 and can slide back and forth along the guiding direction of the guiding element 321; the filtering module 4 is detachably arranged on the stirring portion 322; the pulling element 323, the pulling element 323 is horizontally fixedly arranged on one side of the guiding element 321, and one end of the pulling element 323 is fixedly connected to the guiding element 321, and the other end is fixedly connected to the stirring portion 322; the pulling element 323 is used to continuously pull the stirring portion 322 close to the stirring shaft 31.

[0050] The traction element 323 is specifically a tension spring, one end of which is fixedly connected to the guide element 321 and the other end is fixedly connected to the stirring part 322; the guide element 321 is composed of a fixing member and a first guide rod and a second guide rod vertically arranged on the side wall of the fixing member; the tension spring is coaxially sleeved and installed outside the first guide rod; when it is necessary to stir the liquid medicine in the upper decolorization cylinder 211 so that it is fully in contact with the activated carbon and achieves efficient decolorization, first connect an external power supply to start the rotating drive element 35. After the rotating drive element 35 is started, it drives the stirring shaft 31 to rotate, and the stirring shaft 31 further drives the stirring unit 32 to move, so as to achieve uniform stirring of the liquid medicine in the upper decolorization cylinder 211. In order to improve the coverage and effect of stirring, when the stirring shaft 31 rotates at a higher speed, the stirring part 322 overcomes the limitation of the traction element 323 under the action of centrifugal force and slides to the far end, changing the stirring position, and ensuring that the liquid medicine is evenly mixed in the entire decolorization cylinder 21. This can optimize the contact efficiency between activated carbon and the drug solution and promote the rapid adsorption and decolorization of the pigment in the drug solution.

[0051] When the driving speed of the stirring shaft 31 decreases, the stirring portion 322 returns to the initial position close to the stirring shaft 31 under the action of the traction element 323. By intermittently adjusting the rotation speed of the stirring shaft 31, stirring of the liquid medicine at different positions and sufficient mixing of the activated carbon can be achieved.

[0052] The stirring device can realize dynamic adjustment and stirring of the drug solution in the decolorization cylinder 21, so that the drug solution and the activated carbon are fully mixed, which significantly improves the decolorization efficiency and uniformity. This solution avoids the problem of incomplete decolorization due to incomplete stirring coverage, and ensures that the drug solutions at different depths and positions can be fully stirred by adjusting the stirring speed, thereby improving the decolorization quality and overall process stability of drug production.

[0053] See also Fig. 9 As shown: the stirring part 322 is composed of a sliding member 3221 and a rectangular frame 3222 vertically arranged under the sliding member 3221; the top surface of the rectangular frame 3222 is also provided with a receiving groove 3223 capable of storing activated carbon and a slot 3224 penetrating through one side of the rectangular frame 3222.

[0054] The filter module 4 is detachably arranged in the slot 3224 , thereby cooperating with the rectangular frame 3222 to form a stirring portion 322 capable of stirring the medicinal liquid; the sliding member 3221 is slidably matched with the guide element 321 , thereby achieving the effect of being able to slide freely along the guiding direction of the guide element 321 .

[0055] See also Fig. 9As shown: the stirring module 3 also includes a third guide rod 37 and a scraper 38 that can slide back and forth along the long side direction of the rectangular frame 3222, the third guide rod 37 is vertically fixed to one side of the driving rod 34 and the rod portion of the third guide rod 37 is slidably matched with the scraper 38, and the third guide rod 37 is used to guide and drive the scraper 38 to move.

[0056] The surface of the rectangular frame 3222 is also fixed with a guide frame 39 that can guide the scraper 38 to slide; in the process of driving the stirring shaft 31 to rotate and using the stirring unit 32 to stir the liquid medicine, the filter module 4 will rotate synchronously with the stirring unit 32, so that it can continuously intercept the activated carbon in the liquid medicine, so that the activated carbon is evenly attached to the surface of the filter module 4. This design can effectively increase the contact area between the activated carbon and the liquid medicine, thereby enhancing the adsorption efficiency of the pigment in the liquid medicine until the pigment is completely removed. In order to reduce the long filtration cycle in the subsequent filtration link, when a large amount of activated carbon is adsorbed on the surface of the filter module 4, it is only necessary to connect the external power supply to drive the lifting element 36 to work. The lifting element 36 drives the driving rod 34 to move axially upward in the stirring shaft 31, and synchronously drives the third guide rod 37, so that the scraper 38 is driven by the third guide rod 37 to move upward from the bottom of the rectangular frame 3222, and the activated carbon attached to the surface of the filter module 4 is scraped into the receiving groove 3223 at the top of the rectangular frame 3222. When the stirring shaft 31 is in a non-driving state, the third guide rod 37 is used to guide the scraper 38 to slide radially and always be in the starting position. In this way, partial automatic collection of activated carbon is achieved, effectively reducing the time and complexity of subsequent filtration.

[0057] This design improves the adsorption efficiency of activated carbon during the decolorization process through the synchronous interception and filtration module 4, and realizes the automatic collection of activated carbon through the cooperation of the scraper 38 and the receiving tank 3223, which significantly shortens the processing cycle of the subsequent filtration step, simplifies the operation process, and improves the overall decolorization efficiency and production stability.

[0058] See also Figure 4 , Fig. 9 and Fig.10As shown in the figure: the sealing unit 33 includes a sealing plate 331, a rotating frame 332, a spring 333, a fixed plate 334 and a one-way driving element 335; the sealing plate 331, the sealing plate 331 is coaxially rotatably arranged outside the stirring shaft 31 through the rotating frame 332, and the sealing plate 331 is arranged in multiple groups along the circumferential direction of the axis of the rotating frame 332; the fixed plate 334, the fixed plate 334 is vertically arranged on the rotating frame 332 and arranged close to the edge of the rotating frame 332; the one-way driving element 335, the one-way driving element 335 is coaxially fixedly arranged outside the stirring shaft 31 and located above the rotating frame 332; the spring 333, the spring 333 is coaxially fixedly arranged outside the stirring shaft 31, and the two ends of the spring 333 are respectively in contact with the adjacent surfaces of the rotating frame 332 and the one-way driving element 335; wherein the one-way driving element 335 is provided with a driving plate 3351 that can be flipped unidirectionally.

[0059] In the non-working state, the rotating frame 332 keeps applying pressure to the sealing ring under the continuous support of the spring 333, thereby ensuring that the sealing plate 331 can tightly close the conduction channel between the upper and lower adjacent groups of decolorization cylinders 21, providing a reliable sealing effect to prevent leakage or cross contamination of the liquid medicine.

[0060] The one-way driving element 335 also includes a fixed ring 3352 and a rotating ring 3353 coaxially rotatably arranged under the fixed ring 3352. The driving plate 3351 is rotatably arranged on one side of the fixed ring 3352 through a torsion spring 3355. A limiting plate 3354 is also vertically arranged on the side wall of the fixed ring 3352. Under the action of the torsion spring 3355, the driving plate 3351 is always in contact with the limiting plate 3354.

[0061] When the stirring shaft 31 rotates clockwise driven by the rotating driving element 35 , the driving plate 3351 in the one-way driving element 335 will contact the fixing plate 334 and avoid the limiting plate 3354 under the action of torque, ensuring normal rotation without triggering the rotating frame 332 to move.

[0062] When the rotating frame 332 needs to rotate to expose the inlet of the conducting bin 22, the stirring shaft 31 only needs to rotate counterclockwise by rotating the driving element 35. At this time, the driving plate 3351 cannot be turned over due to the blockage of the limiting plate 3354, and the rotational force applied by the driving plate 3351 is transmitted to the fixing plate 334, causing the rotating frame 332 to rotate. As the rotating frame 332 rotates, the entrance of the conduction chamber 22 is exposed, so that the medicine liquid can flow from the upper decolorization cylinder 211 into the next decolorization cylinder 21 such as the middle decolorization cylinder 212 or further into the lower decolorization cylinder 213 for conduction, thereby realizing the step-by-step conduction and decolorization treatment of the medicine liquid in different temperature environments; further, in order to ensure that the angle of each rotation of the rotating frame 332 is consistent, when the feed port of the conduction chamber 22 needs to be opened, the stirring shaft 31 will first rotate to a preset angle under the drive of the rotating drive element 35, thereby ensuring that the drive of the driving plate 3351 is always consistent, and the driving plates 3351 in the middle decolorization cylinder 212 and the lower decolorization cylinder 213 have a directional deviation from the starting angle of the driving plate 3351 in the upper decolorization cylinder 211, thereby ensuring that when the discharge port of the upper decolorization cylinder 211 is opened, the discharge ports in the middle decolorization cylinder 212 and the lower decolorization cylinder 213 will not be opened synchronously.

[0063] This structure achieves precise control of the conduction channel of the decolorization cylinder 21 through a bidirectional driving mechanism, and realizes flexible sealing and opening in different states of clockwise and counterclockwise rotation, ensuring the safe and efficient transmission of the drug solution in a multi-stage decolorization environment, helping to optimize the decolorization effect and improve production stability.

[0064] See also Figure 8 As shown: the filtering module 4 is a stainless steel screen 41.

[0065] The filtering module 4 is not limited to the stainless steel mesh 41 and may also be a microporous filter membrane, so as to enable the water source to pass through while effectively filtering the activated carbon, thereby achieving the effect of continuous filtering of the activated carbon.

[0066] See also Figure 2 , Figure 3 and Figure 5 As shown: the dynamic heating module 5 includes an outer guide cylinder 51, a heating module 52 and a linear drive 53; the outer guide cylinder 51, the outer guide cylinder 51 is coaxially fixedly arranged outside the decolorization module 2; the heating module 52, the heating module 52 is coaxially slidably arranged in the outer guide cylinder 51; the linear drive 53, the linear drive 53 is vertically fixedly arranged on one side of the outer guide cylinder 51 and the driving end is fixedly connected to the heating module 52.

[0067] The linear drive 53 is specifically a ball screw.

[0068] The outer guide cylinder 51 is composed of an outer cylinder body and an inner cylinder body of different diameters, which are coaxially arranged and form an annular conduction channel therebetween; the heating module 52 is arranged in the annular conduction channel to heat the decolorizing cylinder 21 by heat conduction. The heating module 52 includes a shell and a heating wire assembly wound in the shell, and an electromagnetic induction coil can also be used as a heating device to achieve efficient temperature regulation and uniform heating.

[0069] When it is necessary to heat the upper bleaching cylinder 211, the middle bleaching cylinder 212 or the lower bleaching cylinder 213 respectively, it is only necessary to connect an external power supply to start the linear drive 53, so that the heating module 52 moves axially along the annular conduction channel and is positioned to the specified heating position. The heating module 52 can perform independent heating operations on different bleaching cylinders 21 through its movable design to meet different temperature requirements during the bleaching process. The starting heating position is usually set at the upper bleaching cylinder 211, and can be extended to the middle bleaching cylinder 212 or the lower bleaching cylinder 213 through sequential adjustment to ensure flexible adjustment of temperature control in the bleaching process.

[0070] The combined design of the annular conduction channel and the heating module 52 realizes efficient heating and temperature management of the decolorization cylinder 21. The movable heating module 52 structure enables the device to flexibly provide different heating temperatures for multiple decolorization cylinders 21, which helps to improve the decolorization efficiency of the liquid medicine and maintain the stability of the active ingredients, thereby optimizing the entire decolorization process.

[0071] The invention discloses an application of a decolorizing device with dynamic temperature adjustment in the production of raw materials, which is applied to a decolorizing device with dynamic temperature adjustment, and comprises the following steps:

[0072] S1: dissolving the drug to be decolorized in a solvent, adding an appropriate amount of activated carbon and stirring to ensure full dissolution, so as to form a uniform drug solution; then pouring the drug solution into the upper decolorization cylinder 211, immediately connecting the power supply and starting the rotating drive element 35, so that the stirring shaft 31 drives the stirring unit 32 to rotate, and fully stirring the drug solution in the upper decolorization cylinder 211;

[0073] S2: While the liquid medicine is being decolorized, the dynamic heating module 5 is operated to heat the upper decolorization cylinder 211, thereby increasing the temperature of the liquid medicine in the upper decolorization cylinder 211 to improve the adsorption capacity of the activated carbon, so that the pigment in the liquid medicine is efficiently adsorbed by the activated carbon under heating and stirring;

[0074] S3: When the liquid medicine in the upper decolorizing cylinder 211 reaches the expected decolorizing effect, the sealing unit 33 is adjusted by controlling the reverse movement of the stirring shaft 31, thereby opening the conduction channel of the conduction chamber 22, so that the liquid medicine automatically flows into the middle decolorizing cylinder 212 or the lower decolorizing cylinder 213; in this process, the heat insulation layer 23 is used to avoid heat conduction, ensuring that the temperature in each decolorizing cylinder 21 is independently controlled; the dynamic heating module 5 then heats the liquid medicine in the middle decolorizing cylinder 212 or the lower decolorizing cylinder 213, so that it continues to decolorize under the new temperature environment;

[0075] S4: After the decolorization is completed, the driving rod 34 is driven by the lifting element 36 to move, driving the scraper 38 to scrape the activated carbon adsorbed on the surface of the filter module 4 from bottom to top into the receiving tank 3223, so as to separate the solid and liquid and remove most of the activated carbon in the liquid medicine. Finally, the discharge port of the lower decolorization cylinder 213 is opened to discharge the liquid medicine.

[0076] The present invention can not only efficiently adsorb the pigment in the drug solution but also flexibly adjust the heating temperature of the drug solution according to the decolorization requirements during the decolorization process.

[0077] The above embodiments only express one or several implementation modes of the present invention, and the description thereof is relatively specific and detailed, but it cannot be understood as limiting the protection of the present invention. It should be pointed out that, for a person of ordinary skill in the art, several variations and improvements can be made without departing from the concept of the present invention, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the attached claims.

Claims

1. A decolorization device with dynamic temperature adjustment, characterized in that: include: A base frame (1); a decolorization module (2), the decolorization module (2) being fixedly arranged on the base frame (1) in a vertical state; the decolorization module (2) being provided with a plurality of groups of decolorization cylinders (21) capable of providing different decolorization temperatures, and the plurality of groups of decolorization cylinders (21) being arranged in sequence and in communication with each other; a stirring module (3), the stirring module (3) being rotatably arranged in the decolorization module (2), and being used for stirring the liquid medicine in the decolorization module (2); the stirring module (3) being provided with a stirring shaft (31), a stirring unit (32) coaxially fixedly arranged outside the stirring shaft (31), and a sealing unit (33) capable of continuously blocking the conduction channel between two adjacent groups of decolorization cylinders (21); the stirring unit (3 2) and the sealing unit (33) are provided with a plurality of groups and are arranged one-to-one with the plurality of groups of decolorizing cylinders (21); the filtering module (4) is detachably arranged at the stirring end of the stirring module (3); the dynamic heating module (5) is coaxially fixedly arranged outside the decolorizing module (2); the stirring module (3) further comprises a driving rod (34), a rotating driving element (35) and a lifting element (36); the driving rod (34), the driving rod (34) being coaxially slidably arranged inside the stirring shaft (31); the stirring shaft (31), the stirring shaft (31) being a hollow cylindrical rod body with openings at both ends and a side wall having an oblong through hole (341) radially opened; the rotating driving element (35) being vertically fixedly arranged on the top of the decolorizing module (2) through a first mounting frame The stirring shaft (31) is connected to the driving end of the stirring shaft (31); the lifting element (36) is fixedly arranged on one side of the decolorizing module (2) in a vertical state, and the lifting end is fixedly connected to the top of the driving rod (34) through a connecting frame; the stirring unit (32) comprises a guiding element (321), a stirring portion (322) and a pulling element (323); the guiding element (321) is fixedly arranged coaxially outside the stirring shaft (31); the stirring portion (322) is slidably arranged on the guiding end of the guiding element (321) and can reciprocate along the guiding direction of the guiding element (321); the filtering module (4) is detachably arranged on the stirring portion (322). ; a traction element (323), wherein the traction element (323) is horizontally fixedly arranged on one side of the guide element (321), and one end of the traction element (323) is fixedly connected to the guide element (321), and the other end is fixedly connected to the stirring portion (322); the traction element (323) is used to continuously pull the stirring portion (322) close to the stirring shaft (31); the stirring portion (322) is composed of a sliding member (3221) and a rectangular frame (3222) vertically arranged under the sliding member (3221); the top surface of the rectangular frame (3222) is also provided with a receiving groove (3223) capable of storing activated carbon, and a slot (3224) penetrating through one side of the rectangular frame (3222);The stirring module (3) further comprises a third guide rod (37) and a scraper (38) capable of sliding back and forth along the long side direction of the rectangular frame (3222); the third guide rod (37) is vertically fixed to one side of the driving rod (34) and the rod portion of the third guide rod (37) is slidably matched with the scraper (38); the third guide rod (37) is used to guide and drive the scraper (38) to move; the sealing unit (33) comprises a sealing plate (331), a rotating frame (332), a spring (333), a fixed plate (334) and a one-way driving element (335); the sealing plate (331) is coaxially rotatably arranged outside the stirring shaft (31) through the rotating frame (332); the sealing plate (331) is arranged outside the stirring shaft (31) through the rotating frame (332); the sealing plate (331) is arranged outside the stirring shaft (31) through the rotating frame (332); the sealing plate (331) is coaxially rotatably arranged outside the stirring shaft (31) 31) are arranged along the axis of the rotating frame (332) in a plurality of groups; a fixed plate (334), the fixed plate (334) is arranged vertically on the rotating frame (332) and is arranged close to the edge of the rotating frame (332); a one-way driving element (335), the one-way driving element (335) is coaxially fixedly arranged outside the stirring shaft (31) and is located above the rotating frame (332); a spring (333), the spring (333) is coaxially fixedly arranged outside the stirring shaft (31), and the two ends of the spring (333) are respectively in contact with the adjacent surfaces of the rotating frame (332) and the one-way driving element (335); wherein the one-way driving element (335) is provided with a driving plate (3351) that can be flipped in one direction. ; 2. A decolorization device with dynamic temperature adjustment according to claim 1, characterized in that: The decolorization module (2) further comprises a conduction bin (22) capable of connecting a plurality of groups of decolorization cylinders (21) in series, wherein the plurality of groups of decolorization cylinders (21) are respectively an upper decolorization cylinder (211), a middle decolorization cylinder (212) and a lower decolorization cylinder (213); the conduction bin (22), wherein the feed inlet and the discharge outlet of the conduction bin (22) are respectively connected to the liquid outlet and the liquid inlet of the upper and lower decolorization cylinders; and heat insulation layers (23) are respectively provided between the upper decolorization cylinder (211), the middle decolorization cylinder (212) and the lower decolorization cylinder (213), wherein the heat insulation layers (23) are used to block the conduction of heat energy between adjacent decolorization cylinders (21).

3. A decolorization device with dynamic temperature adjustment according to claim 2, characterized in that: The filter module (4) is a stainless steel screen (41).

4. A decolorization device with dynamic temperature adjustment according to claim 3, characterized in that: The dynamic heating module (5) comprises an outer guide cylinder (51), a heating module (52) and a linear drive (53); the outer guide cylinder (51), the outer guide cylinder (51) being coaxially fixedly arranged outside the decolorization module (2); the heating module (52), the heating module (52) being coaxially slidably arranged inside the outer guide cylinder (51); and the linear drive (53), the linear drive (53) being fixedly arranged on one side of the outer guide cylinder (51) in a vertical state and having a driving end fixedly connected to the heating module (52).

5. Application of a dynamic temperature-adjustable decolorization device in the production of bulk drugs, applied to a dynamic temperature-adjustable decolorization device as described in any one of claims 2 to 4, characterized in that: The following steps are involved: S1: dissolving the drug to be decolorized in a solvent, adding an appropriate amount of activated carbon and stirring to ensure full dissolution, so as to form a uniform drug solution; then pouring the drug solution into the upper decolorization cylinder (211), immediately connecting a power source and starting the rotating drive element (35), so that the stirring shaft (31) drives the stirring unit (32) to rotate, and fully stirring the drug solution in the upper decolorization cylinder (211); S2: while the liquid medicine is being decolorized, the dynamic heating module (5) is actuated to heat the upper decolorization cylinder (211), thereby increasing the temperature of the liquid medicine in the upper decolorization cylinder (211) to improve the adsorption capacity of the activated carbon, so that the pigment in the liquid medicine is efficiently adsorbed by the activated carbon under heating and stirring; S3: When the liquid medicine in the upper decolorizing cylinder (211) reaches the expected decolorizing effect, the sealing unit (33) is adjusted by controlling the reverse movement of the stirring shaft (31), thereby opening the conduction channel of the conduction chamber (22), so that the liquid medicine automatically flows into the middle decolorizing cylinder (212) or the lower decolorizing cylinder (213); in this process, the heat insulation layer (23) is used to avoid heat conduction, ensuring that the temperature in each decolorizing cylinder (21) is independently controlled; the dynamic heating module (5) then heats the liquid medicine in the middle decolorizing cylinder (212) or the lower decolorizing cylinder (213), so that it continues to decolorize under the new temperature environment; S4: After the decolorization is completed, the driving rod (34) is driven by the lifting element (36) to move, thereby driving the scraper (38) to scrape the activated carbon adsorbed on the surface of the filter module (4) from bottom to top into the receiving tank (3223), thereby performing solid-liquid separation and removing most of the activated carbon in the liquid medicine. Finally, the discharge port of the lower decolorization cylinder (213) is opened to discharge the liquid medicine.

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