Biomedical preparation production mixing device and use method thereof

Abstract

The invention discloses a biological medicine preparation production mixing device and a using method thereof, belongs to the field of medicine production devices, and can solve the problems that in the background technology, an existing mixing device can only conduct simple mixing, and after mixing, medicine needs to be taken according to the gram number of medicine, so that the operation is inconvenient. And due to multiple processes, bacteria are easily bred when medicines are in contact with air and operators for a long time, and time and labor are wasted. The method comprises the steps that S1, different agents are placed in a storage barrel, a feeding pump is powered on, and the agents are pumped out and enter an inner sleeve; s2, electrifying a motor, and driving the medicament to move and fill the inner sleeve through a spiral blade; s3, an electric telescopic rod I is electrified, so that the medicament powder slides into a communicating pipe and then slides into a collecting funnel to fall into a pressing hole; and S4, tabletting is conducted on the second electric telescopic rod.

Description

Technical Field

[0001] The invention belongs to the field of pharmaceutical production devices, in particular to a biopharmaceutical preparation production mixing device and a use method thereof. Background Art

[0002] After biopharmaceuticals are extracted, they need to be mixed into various medicines and then made into tablets. Existing mixing devices can only perform simple mixing. After mixing, they need to be separated according to the grams of the medicines. The many steps will cause the medicines to be in contact with the air and operators for a long time, which is easy to breed bacteria, and it is time-consuming and labor-intensive. Summary of the invention

[0003] The purpose of the present invention is to solve the above problems existing in the prior art and to provide a biopharmaceutical preparation production mixing device and a method of using the same.

[0004] To achieve the above purpose, the present invention adopts the following technical solutions:

[0005] A mixing device for producing biopharmaceutical preparations, comprising: a box assembly, a mixing device, an adjusting device and a tablet-making device, wherein the mixing device and the adjusting device are fixed inside the box assembly, and the mixing device and the adjusting device are provided in plurality, wherein the plurality of mixing devices and the plurality of adjusting devices are staggered up and down, and one adjusting device is fixedly connected between every two mixing devices, and the tablet-making device is fixed inside the box assembly, and the tablet-making device is located below the adjusting device at the lowest end.

[0006] The box assembly includes: a box, a material storage barrel and a feeding pump. The upper end of the box is fixed with a material storage barrel, and the material storage barrels are arranged in plurality. The lower end of each material storage barrel is fixedly connected to a feeding pump.

[0007] The plurality of mixing devices all include: an outer sleeve, an outer sleeve hole, an inner sleeve assembly and a vibration device. The outer sleeve is provided with a plurality of outer sleeve holes penetrating along its length direction. The inner sleeve assembly slides into the outer sleeve. The outer sleeve of the mixing device at the uppermost end is provided with a plurality of outer sleeve holes opening downward. A vibration device is fixed above the outer sleeve of the mixing device at the uppermost end. One end of the outer sleeve is fixedly connected to the inner wall of the box body.

[0008] The inner sleeve assembly comprises: an inner sleeve, an inner sleeve hole, a feed port, a shaft bracket, a rotating shaft, a spiral blade, a baffle, a motor and an electric telescopic rod. The inner sleeve slides into the outer sleeve, and the inner sleeve is provided with a plurality of inner sleeve holes penetrating along its length direction. The plurality of inner sleeve holes correspond to the plurality of outer sleeve holes one by one. The upper end of the inner sleeve is provided with a feed port, a shaft bracket is fixed inside the outer sleeve hole, one end of the rotating shaft rotates in the shaft bracket, a spiral blade is fixed on the shaft bracket, a baffle is vertically fixed inside the inner sleeve, a motor is fixed inside the inner sleeve, the rotating shaft seal rotates through the baffle and is fixedly connected to the motor output shaft, a fixed end of the electric telescopic rod is fixedly connected to the inner wall of the other end of the box body, and the feed port is fixedly connected to the discharge end of the feeding pump through a feeding pipe.

[0009] The regulating device includes: a fixed column, a connecting pipe and a regulating valve. The fixed column is horizontally fixed in the box body. A plurality of connecting pipes are fixed on the fixed column. A regulating valve is provided on each connecting pipe. The plurality of outer sleeve holes provided in the upper and lower mixing devices are fixedly connected through the connecting pipe.

[0010] The film-making device comprises: a shell, a collecting funnel, a fixed plate, an inclined bottom hole, a pressure hole, a limit plate, a limit plate hole, a spring, a fixed bracket and an electric telescopic rod. The shell is fixed inside the box, and a plurality of the collecting funnels are fixedly connected to the top surface of the box. The plurality of collecting funnels correspond to and are fixedly connected to the plurality of connecting pipes of the adjusting device at the bottom. The shell is fixed inside the fixed plate, and a plurality of the inclined bottom holes are arranged on the fixed plate. The plurality of the inclined bottom holes are respectively located below the plurality of the collecting funnels. The fixed plate is provided with a plurality of penetrating pressure holes, and each of the pressure holes is divided into The spring is connected to the fixing plate of the fixing plate, and the fixing plate is connected to the fixing plate of the fixing plate. The fixing plate ...

[0011] A method for using a mixing device for producing a biopharmaceutical preparation, the method comprising the following steps:

[0012] S1: Place different reagents in the storage barrels respectively, power on the feeding pump to pump the reagents into the inner casing;

[0013] S2: Power on the motor to drive the medicine to move through the spiral blades and fill the inner sleeve;

[0014] S3: Turn on the electric telescopic rod to make the medicine powder slide into the connecting pipe, and then slide into the collecting funnel and fall into the pressure hole;

[0015] S4: Press the electric telescopic rod 2.

[0016] Compared with the prior art, the present invention has the following beneficial effects:

[0017] The present invention provides a mixing device for the production of biopharmaceutical preparations, which can solve the problem raised in the background technology that the existing mixing device can only perform simple mixing, and after mixing, it needs to be separated according to the grams of the medicine, and the many processes will cause the medicine to be in contact with the air and operators for a long time, which is easy to breed bacteria and time-consuming and labor-intensive. The device can also control the content of the medicines when separating, and can simultaneously produce tablets with different contents of medicine components. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is a schematic diagram of the overall structure.

[0019] Figure 2 is a schematic diagram of the structure of the mixing device;

[0020] Figure 3 1. It is a schematic diagram of the structure of the inner sleeve assembly;

[0021] Figure 4 It is a partial enlarged view of the inner sleeve assembly;

[0022] Figure 5 is a schematic diagram of the structure of the regulating device;

[0023] Figure 6 It is a schematic diagram of the structure of the film-making device;

[0024] Figure 7 It is a partial enlarged view of the film-making device. DETAILED DESCRIPTION

[0025] The technical solution of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0026] A mixing device for producing biopharmaceutical preparations, comprising: a box assembly 1, a mixing device 2, an adjusting device 3 and a tableting device 4, wherein the mixing device 2 and the adjusting device 3 are fixed inside the box assembly 1, and the mixing device 2 and the adjusting device 3 are provided in plurality, and the plurality of the mixing devices 2 and the plurality of the adjusting devices 3 are staggered up and down, and one adjusting device 3 is fixedly connected between every two of the mixing devices 2, and the tableting device 4 is fixed inside the box assembly 1, and the tableting device 4 is located below the adjusting device 3 at the lowest end.

[0027] The box assembly 1 includes: a box 1-1, a material storage barrel 1-2 and a feeding pump 1-3. The material storage barrel 1-2 is fixed to the upper end of the box 1-1. The material storage barrel 1-2 is arranged in plurality, and each of the material storage barrels 1-2 is fixedly connected to a feeding pump 1-3 at the lower end.

[0028] The plurality of mixing devices 2 all include: an outer sleeve 2-1, an outer sleeve hole 2-2, an inner sleeve assembly 2-3 and a vibration device 2-4. The outer sleeve 2-1 is provided with a plurality of outer sleeve holes 2-2 penetrating along its length direction. The inner sleeve assembly 2-3 slides into the outer sleeve 2-1. The outer sleeve 2-1 of the mixing device 2 at the uppermost end is provided with a plurality of outer sleeve holes 2-2 openings facing downward. A vibration device 2-4 is fixed above the outer sleeve 2-1 of the mixing device 2 at the uppermost end. One end of the outer sleeve 2-1 is fixedly connected to the inner wall of the box body 1-1.

[0029] The inner sleeve assembly 2-3 includes: an inner sleeve 2-3-1, an inner sleeve hole 2-3-2, a feed port 2-3-3, an axis support 2-3-4, a rotating shaft 2-3-5, a spiral blade 2-3-6, a baffle 2-3-7, a motor 2-3-8 and an electric telescopic rod 2-3-9. The inner sleeve 2-3-1 slides into the outer sleeve 2-1. The inner sleeve 2-3-1 is provided with a plurality of inner sleeve holes 2-3-2 penetrating along its length direction. The plurality of inner sleeve holes 2-3-2 correspond to the plurality of outer sleeve holes 2-2 one by one. The upper end of the inner sleeve 2-3-1 is provided with a feed port 2-3-3. The outer sleeve hole A shaft bracket 2-3-4 is fixed inside 2-2, one end of the rotating shaft 2-3-5 rotates in the shaft bracket 2-3-4, a spiral blade 2-3-6 is fixed on the shaft bracket 2-3-4, a baffle 2-3-7 is vertically fixed inside the inner sleeve 2-3-1, a motor 2-3-8 is fixed inside the inner sleeve 2-3-1, the rotating shaft 2-3-5 rotates in a sealed manner through the baffle 2-3-7 and is fixedly connected to the output shaft of the motor 2-3-8, the fixed end of the electric telescopic rod 2-3-9 is fixedly connected to the inner wall of the other end of the box body 1-1, and the feed port 2-3-3 is fixedly connected to the discharge end of the feed pump 1-3 through the feed pipe.

[0030] The regulating device 3 includes: a fixed column 3-1, a connecting pipe 3-2 and a regulating valve 3-3. The fixed column 3-1 is horizontally fixed in the box body 1-1. A plurality of connecting pipes 3-2 are fixed on the fixed column 3-1. Each connecting pipe 3-2 is provided with a regulating valve 3-3. The plurality of outer sleeve holes 2-2 provided in the upper and lower mixing devices 2 are fixedly connected through the connecting pipe 3-2.

[0031] The film-making device 4 includes: an outer shell 4-1, a collecting funnel 4-2, a fixed plate 4-3, an inclined bottom hole 4-4, a pressure hole 4-5, a limit plate 4-6, a limit plate hole 4-7, a spring 4-8, a fixed bracket 4-9 and an electric telescopic rod 4-10. The outer shell 4-1 is fixed inside the box body 1-1, and a plurality of the collecting funnels 4-2 are fixedly connected to the top surface of the box body 1-1. The plurality of collecting funnels 4-2 correspond to and are fixedly connected to the plurality of connecting pipes 3-2 of the lowermost adjusting device 3. The outer shell 4-1 is fixed inside the fixed plate 4-3, and a plurality of the inclined bottom holes 4-4 are arranged on the fixed plate 4-3. The plurality of the inclined bottom holes 4-4 are respectively located below the plurality of the collecting funnels 4-2. The fixed plate 4-3 is provided with a plurality of penetrating pressure holes 4-5, and each of the pressure holes 4-5 are respectively connected to one of the inclined bottom holes 4-4, and the shell 4-1 is internally slidably connected with a limit plate 4-6, and the limit plate 4-6 is provided with a plurality of limit plate holes 4-7, and the plurality of limit plate holes 4-7 correspond one to one with the plurality of pressure holes 4-5. One end of the spring 4-8 is fixed in the fixed plate 4-3, and the other end of the spring 4-8 is fixedly connected to the limit plate 4-6. A fixed bracket 4-9 is fixed on the fixed plate 4-3, and an electric telescopic rod 4-10 is fixed at the lower end of the fixed bracket 4-9. A pressure plate is provided at the movable end of the electric telescopic rod 4-10, and the pressure plate is provided in the pressure hole 4-5. The fixed bracket 4-9 and the electric telescopic rod 4-10 are both provided in plurality, and the plurality of fixed brackets 4-9 and the electric telescopic rod 4-10 correspond one to one with the plurality of pressure holes 4-5, respectively.

[0032] A method for using a mixing device for producing a biopharmaceutical preparation, the method comprising the following steps:

[0033] S1: Place different medicines in the storage barrel 1-2 respectively, and energize the feeding pump 1-3 to pump the medicines into the inner sleeve 2-3-1;

[0034] S2: The motor 2-3-8 is powered on to drive the medicine to move through the spiral blade 2-3-6 and fill the inner sleeve 2-3-1;

[0035] S3: Power on the electric telescopic rod 2-3-9 to make the medicine powder slide into the connecting pipe 3-2, and then slide into the collecting funnel 4-2 and fall into the pressure hole 4-5;

[0036] S4: Press the electric telescopic rod 24-10.

[0037] The working principle of the present invention is:

[0038] In the initial state of the device, the outer sleeve hole 2-2 and the inner sleeve hole 2-3-2 are arranged alternately, the pressure hole 4-5 and the limit plate hole 4-7 are arranged alternately, and different medicines are placed in the storage barrel 1-2 respectively. The device is connected to an external power supply, and the feeding pump 1-3 is powered on to extract the medicine inside the storage barrel 1-2 and enter the inner sleeve 2-3-1 through the feeding pipe and the feed port 2-3-3. The baffle 2-3-7 plays a role in protecting the motor 2-3-8. The motor 2-3-8 is powered on to drive the spiral blade 2-3-1 through the rotating shaft 2-3-5. 6 rotates, the spiral blade 2-3-6 rotates to drive the medicine to move to the right and fill the inner sleeve 2-3-1. Multiple mixing devices 2 are set to fill medicines with different components at the same time. The electric telescopic rod 2-3-9 set in the multiple inner sleeve assemblies 2-3 is energized and extended to drive the inner sleeve 2-3-1 to slide into the outer sleeve 2-1 until the outer sleeve hole 2-2 coincides with the inner sleeve hole 2-3-2, and the medicine powder slides into the connecting pipe 3-2, and then slides into the collecting funnel 4-2 through the connecting pipe 3-2 at the bottom, and then the electric telescopic rod 2-3 -9 is powered on to reset, thereby driving the inner sleeve 2-3-1 to reset so that the inner sleeve hole 2-3-2 is misaligned with the outer sleeve hole 2-2, and the spiral blade 2-3-6 rotates to continue filling, completing a mixing of the medicines. The regulating valve 3-3 on the connecting pipe 3-2 can be controlled separately to control the amount of medicines passing through the connecting pipe 3-2, thereby making tablets with different contents of medicine ingredients at the same time. The vibration device 2-4 is powered on to generate vibration, which can assist the medicines in sliding down and prevent the medicines from agglomerating and affecting the sliding down. The medicines slide to the inclined bottom through the collecting funnel 4-2. The medicine is pressed into the hole 4-4, and then slides from the inclined bottom hole 4-4 to the connected pressure hole 4-5. The electric telescopic rod 2 4-10 is energized and extended through the pressure plate to squeeze the medicine. The medicine can be pressed into a sheet by cooperating with the limit plate 4-6. After the pressing is completed, the electric telescopic rod 2 4-10 is controlled to reset, and the limit plate 4-6 is pushed inward to make the limit plate hole 4-7 coincide with the pressure hole 4-5. At the same time, the spring 4-8 is compressed. At this time, the tablets slide down and can be collected. After the collection is completed, the limit plate 4-6 is released, and the limit plate 4-6 is reset by the action of the spring 4-8 for the next pressing. The above method can solve the problem raised in the background technology: the existing mixing device can only perform simple mixing, and after mixing, it needs to be divided according to the gram weight of the medicine. The many processes will cause the medicine to be in contact with the air and the operator for a long time, which is easy to breed bacteria and time-consuming and labor-intensive.

[0039] It will be apparent to those skilled in the art that the invention is not limited to the details of the exemplary embodiments described above and that the invention can be implemented in other forms without departing from the spirit or essential features of the invention. Therefore, the embodiments should be considered in all respects as exemplary and non-limiting, and the scope of the invention is defined by the appended claims rather than the foregoing description, and it is intended that all variations within the meaning and range of equivalents of the claims be included in the invention. Any reference numeral in a claim should not be considered as limiting the claim to which it relates.

[0040] In addition, it should be understood that although the present specification is described according to implementation modes, not every implementation mode contains only one independent technical solution. This description of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment may also be appropriately combined to form other implementation modes that can be understood by those skilled in the art.

Claims

1. A mixing device for producing biopharmaceutical preparations, characterized in that: include: A box assembly (1), a mixing device (2), an adjusting device (3) and a tablet-making device (4); the mixing device (2) and the adjusting device (3) are fixed inside the box assembly (1); the mixing device (2) and the adjusting device (3) are arranged in plurality; the plurality of mixing devices (2) and the plurality of adjusting devices (3) are arranged in an alternating manner up and down; one adjusting device (3) is fixedly connected between every two mixing devices (2); the tablet-making device (4) is fixed inside the box assembly (1); the tablet-making device (4) is located below the adjusting device (3) at the lowest end.

2. A biopharmaceutical preparation production mixing device according to claim 1, characterized in that: The box assembly (1) comprises: a box (1-1), a material storage barrel (1-2) and a feeding pump (1-3); a material storage barrel (1-2) is fixed to the upper end of the box (1-1); a plurality of material storage barrels (1-2) are provided, and a feeding pump (1-3) is fixedly connected to the lower end of each material storage barrel (1-2).

3. A biopharmaceutical preparation production mixing device according to claim 2, characterized in that: The plurality of mixing devices (2) each comprise: an outer sleeve (2-1), an outer sleeve hole (2-2), an inner sleeve assembly (2-3) and a vibration device (2-4); the outer sleeve (2-1) is provided with a plurality of outer sleeve holes (2-2) penetrating along its length direction; the inner sleeve assembly (2-3) slides into the outer sleeve (2-1); the plurality of outer sleeve holes (2-2) provided on the outer sleeve (2-1) of the mixing device (2) at the top end are opened downward; a vibration device (2-4) is fixed above the outer sleeve (2-1) of the mixing device (2) at the top end; and one end of the outer sleeve (2-1) is fixedly connected to the inner wall of the box body (1-1).

4. A biopharmaceutical preparation production mixing device according to claim 3, characterized in that: The inner sleeve assembly (2-3) comprises: an inner sleeve (2-3-1), an inner sleeve hole (2-3-2), a feed port (2-3-3), a shaft support (2-3-4), a rotating shaft (2-3-5), a spiral blade (2-3-6), a baffle (2-3-7), a motor (2-3-8) and an electric telescopic rod (2-3-9); the inner sleeve (2-3-1) is slidably inserted into the outer sleeve (2-1); the inner sleeve (2-3-1) is provided with a plurality of inner sleeve holes (2-3-2) penetrating along its length direction; the plurality of inner sleeve holes (2-3-2) correspond to the plurality of outer sleeve holes (2-2) one by one; the upper end of the inner sleeve (2-3-1) is provided with a feed port (2-3-3); the outer sleeve A shaft support (2-3-4) is fixed inside the hole (2-2); one end of the rotating shaft (2-3-5) rotates inside the shaft support (2-3-4); a spiral blade (2-3-6) is fixed on the shaft support (2-3-4); a baffle (2-3-7) is vertically fixed inside the inner sleeve (2-3-1); a motor (2-3-8) is fixed inside the inner sleeve (2-3-1); the rotating shaft (2-3-5) rotates in a sealed manner through the baffle (2-3-7) and is fixedly connected to the output shaft of the motor (2-3-8); a fixed end of the electric telescopic rod (2-3-9) is fixedly connected to the inner wall of the other end of the box body (1-1); and the feed port (2-3-3) is fixedly connected to the discharge end of the feed pump (1-3) through a feed pipe.

5. A biopharmaceutical preparation production mixing device according to claim 4, characterized in that: The regulating device (3) comprises: a fixed column (3-1), a connecting pipe (3-2) and a regulating valve (3-3); the fixed column (3-1) is horizontally fixed in the box body (1-1); a plurality of connecting pipes (3-2) are fixed on the fixed column (3-1); each connecting pipe (3-2) is provided with a regulating valve (3-3); and a plurality of outer sleeve holes (2-2) provided on the upper and lower mixing devices (2) are fixedly connected via the connecting pipe (3-2).

6. A biopharmaceutical preparation production mixing device according to claim 5, characterized in that: The film-making device (4) comprises: a shell (4-1), a collecting funnel (4-2), a fixing plate (4-3), an inclined bottom hole (4-4), a pressing hole (4-5), a limit plate (4-6), a limit plate hole (4-7), a spring (4-8), a fixing bracket (4-9) and an electric telescopic rod (4-10). The shell (4-1) is fixed inside the box (1-1), and a plurality of the collecting funnels (4-2) are fixedly connected to the top surface of the box (1-1). The collecting funnels (4-2) correspond to the multiple communicating tubes (3-2) of the regulating device (3) at the bottom one by one and are fixedly connected. A fixing plate (4-3) is fixed inside the shell (4-1). The fixing plate (4-3) is provided with multiple oblique bottom holes (4-4). The multiple oblique bottom holes (4-4) are respectively located below the multiple collecting funnels (4-2). The fixing plate (4-3) is provided with multiple penetrating pressure holes (4-5). Each of the pressure holes (4-5) is provided with a pressure hole (4-5). The pressure holes (4-5) are respectively connected to one of the inclined bottom holes (4-4); a limiting plate (4-6) is slidably connected inside the housing (4-1); a plurality of limiting plate holes (4-7) are provided on the limiting plate (4-6); the plurality of limiting plate holes (4-7) correspond to the plurality of pressure holes (4-5) in a one-to-one manner; one end of the spring (4-8) is fixed in the fixing plate (4-3); the other end of the spring (4-8) is fixedly connected to the limiting plate (4-6); the fixing A fixed bracket (4-9) is fixed on the fixed plate (4-3), an electric telescopic rod 2 (4-10) is fixed at the lower end of the fixed bracket (4-9), a pressing plate is arranged at the movable end of the electric telescopic rod 2 (4-10), and the pressing plate is arranged in the pressing hole (4-5), the fixed bracket (4-9) and the electric telescopic rod 2 (4-10) are both arranged in plurality, and the plurality of fixed brackets (4-9) and the electric telescopic rod 2 (4-10) respectively correspond to the plurality of pressing holes (4-5) one by one.

7. A method for using the biopharmaceutical preparation production mixing device according to claim 6, characterized in that: The method comprises the following steps: S1: placing different medicines in the storage barrel (1-2) respectively, and energizing the feeding pump (1-3) to pump the medicines into the inner sleeve (2-3-1); S2: The motor (2-3-8) is energized to drive the medicine to move through the spiral blade (2-3-6) and fill the inner sleeve (2-3-1); S3: Power is supplied to the electric telescopic rod (2-3-9) to make the medicine powder slide into the connecting pipe (3-2), then slide into the collecting funnel (4-2) and fall into the pressure hole (4-5); S4: Press the electric telescopic rod 2 (4-10) into sheets.

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