Multi-channel pulse ablation device

Abstract

The invention provides a multi-channel pulse ablation device, relates to the technical field of medical treatment and is applied to a lung focus tissue channel, and the outer diameter of the pulse ablation device is smaller than the inner diameter of the lung focus tissue channel. The pulse ablation device comprises a multi-cavity tube, an adjusting assembly, at least two sets of ablation catheter assemblies and flexible electrodes corresponding to the ablation catheter assemblies. The multi-cavity tube is used for accommodating at least two groups of ablation catheter components, the adjusting component is connected with each group of ablation catheter components, and the ablation catheter components are connected with the flexible electrode; the at least two sets of ablation catheter assemblies can move in the axial direction of the multi-cavity tube, and the adjusting assembly is used for adjusting the position of each set of ablation catheter assembly so as to adjust the position of the flexible electrode. Thus, the at least two sets of ablation catheter assemblies and the corresponding flexible electrodes can ablate the target focus tissue channel at the same time, the operation time is shortened, the treatment efficiency is improved, meanwhile, the process that the catheter needs to be repeatedly inserted and adjusted is avoided, and repeated damage to patient tissue is reduced.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a multi-channel pulse ablation device. Background Art

[0002] Irreversible electroporation (IRE) is a tissue ablation technique that is widely used to treat a variety of natural cavity diseases, such as thyroid diseases, urinary system diseases, esophageal diseases, intestinal diseases, chronic obstructive pulmonary disease, lung cancer, liver cancer, and kidney cancer. Compared with traditional ablation techniques, IRE inactivates tissues through ablation at the cellular level without destroying tissue structure and protein activity, and can precisely control the ablation range. IRE generates almost no heat during the ablation process, avoiding the heat sink effect, having little impact on surrounding blood vessels, and reducing surgical time and infection risk.

[0003] Although IRE technology has significant advantages, existing pulse ablation devices still have many limitations in actual clinical applications. Existing pulse ablation devices require multiple ablations during treatment, resulting in low efficiency. In addition, existing pulse ablation devices generally rely on endoscopic bending for operation and positioning. Since the lesions are mostly located in complex anatomical structures, the positioning of pulse ablation devices in branches or deep lesions is often not accurate enough, increasing the difficulty of surgery and the risk of failure. Summary of the invention

[0004] The purpose of the present invention is to address the deficiencies of the prior art and provide a multi-channel pulse ablation device. This pulse ablation device adopts a multi-channel structure, which can simultaneously deliver multiple ablation electrodes and each ablation electrode can be independently positioned, thereby achieving simultaneous ablation of multiple electrodes and improving ablation efficiency and ablation effect.

[0005] The present invention provides a multi-channel pulse ablation device, which is applied to a lung lesion tissue channel. The outer diameter of the pulse ablation device is smaller than the inner diameter of the lung lesion tissue channel. The pulse ablation device comprises a multi-lumen tube, an adjustment component, at least two groups of ablation catheter components and flexible electrodes corresponding to each group of ablation catheter components.

[0006] The multi-lumen tube is used to accommodate the at least two groups of ablation catheter assemblies, the adjustment assembly is connected to each group of the ablation catheter assemblies, and the ablation catheter assemblies are connected to the flexible electrodes;

[0007] The at least two groups of ablation catheter assemblies are capable of moving along the axial direction of the multi-lumen tube, and the adjustment assembly is used to adjust the position of each group of ablation catheter assemblies to adjust the position of the flexible electrode.

[0008] In a possible implementation manner, the pulse ablation device further includes a bending adjustment member and a bending adjustment valve;

[0009] The bending adjusting member is disposed between the multi-lumen tube and the at least two groups of ablation catheter components, and the bending adjusting member is connected to the bending adjusting valve;

[0010] The bending regulating valve can adjust the curvature of the bending regulating member to adjust the curvature of the at least two groups of ablation catheter assemblies.

[0011] In a possible implementation, the ablation catheter assembly includes a guide inner core and a handle assembly;

[0012] The guide inner core is arranged between the flexible electrode and the handle assembly, the handle assembly is transmission-connected to the proximal end of the guide inner core, and the distal end of the guide inner core is elastically connected to the flexible electrode.

[0013] In a possible implementation manner, the rigidity of the distal end of the guide inner core is smaller than the rigidity of the proximal end of the guide inner core.

[0014] In a possible implementation manner, the ablation catheter assembly further includes a navigation wire, and the guide inner core is a hollow structure, and the guide inner core is used to accommodate the navigation wire.

[0015] In a possible implementation manner, the ablation catheter assembly includes an information collecting device, wherein the information collecting device is connected to the flexible electrode, and the information collecting device is used to obtain position information of the flexible electrode and / or morphological data of the flexible electrode.

[0016] In a possible implementation, the ablation catheter assembly further includes a pulse cable and a pulse connector, wherein the distal end of the pulse cable is connected to the flexible electrode, the proximal end of the pulse cable is disposed in the pulse connector, and the pulse cable is connected to the pulse ablation system via the pulse connector.

[0017] In a possible implementation manner, the adjustment component includes an adjustment switch, a transmission mechanism and a fine-tuning knob, the fine-tuning knob is connected to the adjustment switch through the transmission mechanism, and the adjustment switch is used to switch the adjustment mode of the ablation catheter assembly;

[0018] In the coarse adjustment mode, the ablation catheter assembly can reciprocate in the multi-lumen tube along the axial direction of the multi-lumen tube;

[0019] In the fine-tuning mode, the fine-tuning knob can drive the ablation catheter assembly to reciprocate along the axial direction of the multi-lumen tube through the transmission mechanism.

[0020] In a possible implementation manner, the rigidity of the distal end of the multi-lumen tube is smaller than the rigidity of the proximal end of the multi-lumen tube.

[0021] In a possible implementation manner, the outer diameter of the multi-lumen tube is 1 mm-4 mm.

[0022] The present application provides a multi-channel pulse ablation device, which has the following beneficial effects:

[0023] The present application provides a multi-channel pulse ablation device, which relates to the field of medical technology and is applied to lung lesion tissue channels. The outer diameter of the pulse ablation device is smaller than the inner diameter of the lung lesion tissue channels. The pulse ablation device includes a multi-lumen tube, an adjustment component, at least two groups of ablation catheter components and flexible electrodes corresponding to each group of ablation catheter components; the multi-lumen tube is used to accommodate at least two groups of ablation catheter components, the adjustment component is connected to each group of ablation catheter components, and the ablation catheter components are connected to the flexible electrodes; at least two groups of ablation catheter components can move along the axial direction of the multi-lumen tube, and the adjustment component is used to adjust the position of each group of ablation catheter components to adjust the position of the flexible electrodes. In this way, at least two groups of ablation catheter components and corresponding flexible electrodes can simultaneously ablate the target lesion tissue channels, reduce operation time, improve treatment efficiency, and avoid the need for repeated insertion and adjustment of catheters, reducing repeated damage to patient tissues. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the following briefly introduces the drawings required for use in the description of the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0025] Figure 1 This is a schematic structural diagram of a multi-channel pulse ablation device according to an embodiment of the present application;

[0026] Figure 2 This is a schematic structural diagram of a first ablation catheter assembly according to an embodiment of the present application;

[0027] Figure 3 This is a schematic diagram of the structure of the flexible electrode according to an embodiment of the present application;

[0028] Figure 4 This is a schematic structural diagram of the guide inner core of an embodiment of the present application;

[0029] Figure 5 This is a schematic diagram of the structure of the adjustment component of an embodiment of the present application;

[0030] Figure 6 It is a cross-sectional view of a multi-channel pulse ablation device according to an embodiment of the present application.

[0031] The following is a supplementary description of the attached drawings:

[0032] 1. First ablation catheter assembly; 11. Flexible electrode; 12. Guide inner core; 121. Distal end of guide inner core; 13. Information collection device; 14. Fixing piece; 15. Pulse cable; 16. First ablation catheter; 2. Second ablation catheter assembly; 3. Multi-lumen tube; 4. Bending adjustment piece; 41. Bending adjustment valve body; 42. Bending adjustment valve stem; 5. Adjustment assembly; 51. Adjustment switch; 52. Fine-tuning knob; 6. Handle assembly; 61. First handle; 7. Connector assembly. DETAILED DESCRIPTION

[0033] In order to enable those skilled in the art to better understand the present application, the technical solutions in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of this application.

[0034] The term "one embodiment" or "embodiment" as used herein refers to a specific feature, structure or characteristic that may be included in at least one implementation of the present application. In the description of the present application, it should be understood that the orientation or positional relationship indicated by the terms "upper", "lower", "top", "bottom", etc. is based on the orientation or positional relationship shown in the accompanying drawings, which is only for the convenience of describing the present application and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation of the present application. In addition, the terms "first" and "second" are used only for descriptive purposes, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, the features defined as "first" and "second" may include one or more of the features explicitly or implicitly. Moreover, the terms "first", "second", etc. are used to distinguish similar objects, and are not necessarily used to describe a specific order or sequence. It should be understood that the data used in this way can be interchangeable where appropriate, so that the embodiments of the present application described here can be implemented in an order other than those illustrated or described here.

[0035] Understandably, irreversible electroporation ablation (IRE) is a new tissue ablation technology. In this method, the doctor guides the treatment device to the location of the lesion through skin puncture or intervention through the natural cavity, and then treats the lesion through the ablation device. Irreversible electroporation ablation is suitable for a variety of natural cavity diseases, such as: thyroid disease, urinary system disease, esophageal disease, intestinal disease, chronic obstructive pulmonary disease, lung cancer, liver cancer, lung cancer, kidney cancer, etc. When biological tissue is in a high-intensity electric field, the permeability of the cell membrane in the tissue is significantly increased, causing extracellular fluid molecules to diffuse into the cell membrane and cause cell death, thereby achieving the purpose of tissue ablation. During the ablation process, the bilayer of lipids in the cell membrane breaks down in the high-intensity electric field, and the bilayer of lipids changes with the changes in the electric field intensity, action time, pulse cycle and number. The ablation technology has also changed from the early reversible electroporation to irreversible electroporation. In recent years, irreversible electroporation ablation has been applied to minimally invasive ablation of various tissues or tumors.

[0036] Compared with traditional tissue ablation techniques, such as radiofrequency ablation (RFA) and microwave ablation (MWA), IRE tissue ablation technology has many significant advantages. For example, IRE inactivates tissue at the cellular level, does not affect tissue structure and protein activity, and can accurately control the scope of tissue inactivation. In addition, IRE generates very little heat during ablation, does not have heat deposition, and has little effect on local blood vessels. During the ablation process, the short IRE ablation time can reduce the tissue surgical exposure time and the possibility of infection complications. In addition, during irreversible electroporation ablation, medical imaging methods such as electronic computed tomography (CT), ultrasound, and magnetic resonance imaging (MRI) can be used to locate the ablation range, monitor the treatment in real time, and observe the postoperative efficacy, making the IRE ablation range more accurate and protecting normal tissue to the maximum extent.

[0037] In the prior art, for tumor diseases, such as lung tumor disease, 2-6 electrodes are placed around the diseased tissue during surgery, but this process is very time-consuming and the positioning may be inaccurate, and the simultaneous delivery of multiple sets of ablation electrodes will increase the risk of complications for patients.

[0038] In view of this, in order to solve at least one of the above problems, the present application provides a multi-channel pulse ablation device which simultaneously adjusts the positions of multiple flexible electrodes 11 by setting at least two groups of ablation catheter assemblies. The device is particularly suitable for irreversible electroporation ablation technology.

[0039] The following describes a multi-channel pulse ablation device provided by an embodiment of the present application in conjunction with the accompanying drawings. The device is applied to a lung lesion tissue channel. The outer diameter of the pulse ablation device is smaller than the inner diameter of the lung lesion tissue channel. The pulse ablation device includes a multi-lumen tube 3, an adjustment component 5, at least two groups of ablation catheter components, and flexible electrodes 11 corresponding to each group of ablation catheter components. The multi-lumen tube 3 is used to accommodate at least two groups of ablation catheter components. The adjustment component 5 is connected to each group of ablation catheter components, and the ablation catheter components are connected to the flexible electrodes 11. At least two groups of ablation catheter components can move along the axial direction of the multi-lumen tube 3. The adjustment component 5 is used to adjust the position of each group of ablation catheter components to adjust the position of the flexible electrode 11. In this way, at least two groups of ablation catheter components and the corresponding flexible electrodes 11 can simultaneously ablate the target lesion tissue channel, reduce the operation time, improve the treatment efficiency, and avoid the need for repeated insertion and adjustment of the catheter, thereby reducing repeated damage to the patient's tissue.

[0040] Specifically, in an embodiment of the present specification, a dual-channel pulse ablation device is provided, which includes two groups of ablation catheter assemblies and corresponding two groups of flexible electrodes 11. The inner diameter of the multi-lumen tube 3 is greater than the sum of the inner diameters of at least two groups of ablation catheter assemblies. The multi-lumen tube 3 is used to transport the ablation electrode. The multi-lumen tube 3 has a first inner cavity and a second inner cavity. The first inner cavity is used to accommodate the first ablation catheter assembly 1, and the second inner cavity is used to accommodate the second ablation catheter assembly 2. The first ablation catheter assembly 1 corresponds to a first flexible electrode, which is arranged at the distal end of the first ablation catheter assembly 1. The second ablation catheter assembly 2 corresponds to a second flexible electrode, which is arranged at the distal end of the second ablation catheter assembly 2. The adjustment component 5 is arranged on the multi-lumen tube 3, and the adjustment component 5 can independently adjust the positions of the first ablation catheter assembly 1 and the second ablation catheter assembly 2 relative to the multi-lumen tube 3, thereby adjusting the positions between the first flexible electrode and the second flexible electrode and the target lesion tissue.

[0041] In another possible implementation, the multi-channel pulse ablation device is a three-channel pulse ablation device.

[0042] Specifically, the first inner cavity has a first axis, the second inner cavity has a second axis, the multi-lumen tube 3 has a preset axis, and the first axis, the second axis and the preset axis are parallel to each other.

[0043] Specifically, the pulse ablation system is connected to a multi-channel pulse ablation device, and the pulse energy emitted by the pulse ablation system is transmitted from the pulse ablation device to the flexible electrode 11 to reach the target lesion tissue to achieve a therapeutic effect.

[0044] In a possible implementation manner, at least two groups of ablation catheter assemblies correspond to at least two groups of flexible electrodes 11 , wherein at least one pair of flexible electrodes 11 forms an electrode loop.

[0045] Specifically, the flexible electrode 11 is used to form a single-stage path and a multi-stage path. In one possible implementation, the first flexible electrode and the second flexible electrode are used to form a single-stage path, and the first flexible electrode and the second flexible electrode respectively form corresponding current paths with the surface electrodes attached to the surface of the human body. In another possible implementation, the first flexible electrode and the second flexible electrode are used to form a multi-stage path, and the first flexible electrode and the second flexible electrode form corresponding current paths to act on the target lesion tissue.

[0046] Specifically, the flexible electrode 11 is a mesh structure, and the flexible electrode 11 is a mesh structure formed by cross-weaving multiple electrode wires. The flexible electrode 11 can change shape, and the flexible electrode 11 can expand and contract, so that the mesh density, tensile performance and structural stability of the flexible electrode 11 are higher, and the flexible electrode 11 can better fit the target lesion tissue, and the fitting area is larger and more uniform, and the treatment effect is better.

[0047] Furthermore, the pulse ablation device further includes a bend adjusting member 4 and a bend adjusting valve; the bend adjusting member 4 is disposed between the multi-lumen tube 3 and at least two groups of ablation catheter assemblies, and the bend adjusting member 4 is connected to the bend adjusting valve; the bend adjusting valve can adjust the curvature of the bend adjusting member 4 to adjust the curvature of at least two groups of ablation catheter assemblies. The curvature of each group of ablation catheter assemblies is independently adjusted by the bend adjusting valve, so as to achieve multi-regional and multi-directional synchronous ablation, thereby improving the accuracy of positioning and the flexibility of operation.

[0048] Specifically, in the embodiment of the present specification, the bending adjusting member 4 is a bending adjusting wire, and the bending adjusting wire is a multi-lumen tube 3 that also has a third inner cavity, and the third inner cavity is used to accommodate the bending adjusting wire, and the bending adjusting valve is connected to the bending adjusting wire, and the bending adjusting valve includes a bending adjusting valve body 41 and a bending adjusting valve stem 42, and the bending adjusting valve body 41 is connected to the proximal end of the multi-lumen tube 3. By rotating the bending adjusting valve stem 42, the bending adjusting wire changes its curvature as the bending adjusting valve stem 42 changes the curvature of the multi-lumen tube 3, and then the curvature of at least two groups of ablation catheter assemblies changes as the multi-lumen tube 3 is bent. By realizing the controllable bending of the bending adjusting member 4 through the bending adjusting valve, the pulse ablation device can conform to the complex curvature of the tissue channel of the lung lesion, and is suitable for complex areas such as branch bronchi or deep lesions.

[0049] Specifically, the first ablation catheter assembly 1 includes a first ablation catheter 16, which is used to cover the first guide inner core and the first cable. The second ablation catheter assembly 2 includes a second ablation pin tube, which is used to accommodate the second guide inner core and the second cable. The multi-lumen tube 3 accommodates the first ablation catheter 16 and the second ablation pin tube, and the first flexible electrode and the second flexible electrode are exposed at the distal end of the multi-lumen tube 3.

[0050] Specifically, the ablation catheter assembly includes a guide inner core 12 and a handle assembly; the guide inner core 12 is arranged between the flexible electrode 11 and the handle assembly, the handle assembly is transmission-connected to the proximal end of the guide inner core 12, and the distal end of the guide inner core 12 is elastically connected to the flexible electrode 11. In this way, the setting of the guide inner core 12 supports the adjustment of the expansion, contraction and fine-tuning position of the flexible electrode 11, and can quickly correct the position of the flexible electrode 11, thereby increasing the accuracy of positioning.

[0051] Specifically, the ablation catheter assembly includes a handle assembly that can accommodate the guide inner core 12 and the pulse cable 15, and the handle assembly includes a first handle 61 and a second handle. The first handle 61 is used to bend the first flexible electrode to adjust the shape and position of the first flexible electrode, and the second handle is used to bend the second flexible electrode to adjust the shape and position of the second flexible electrode. When adjusting the first ablation catheter assembly 1, a pulling force or a pushing force is applied to the first flexible electrode by rotating the first operating member of the first handle 61, thereby changing the curvature of the first flexible electrode, and the first handle 61 can also open or expand the first flexible electrode; when adjusting the second ablation catheter assembly 2, a pulling force or a pushing force is applied to the second flexible electrode by rotating the second operating member of the second handle, thereby changing the curvature of the second flexible electrode, and the second handle can also open or expand the second flexible electrode.

[0052] Specifically, a first insulating member is disposed between the first handle 61 and the first ablation catheter assembly 1 , and a second insulating member is disposed between the second handle and the second ablation catheter assembly 2 .

[0053] Specifically, a first operating member is disposed on the first handle 61 , and the first operating member is slidably connected or rotationally connected to the first handle 61 . A second operating member is disposed on the second handle, and the second operating member is slidably connected or rotationally connected to the second handle.

[0054] Specifically, the rigidity of the distal end of the guide inner core 12 is less than that of the proximal end of the guide inner core 12. Thus, the distal end of the guide inner core 12 has higher flexibility and can easily adapt to the complex anatomical structure inside the human body, which helps to safely pass through narrow or irregular channels, and also helps the ablation catheter to fit the target tissue more naturally during fine-tuning, facilitates the adjustment of the ablation catheter angle, and improves the accuracy of positioning and operation.

[0055] Preferably, the distal end of the guide inner core 12 is made of a metal with good biocompatibility such as medical stainless steel or nickel-titanium alloy.

[0056] Specifically, the guide inner core 12 is a metal wire structure or a metal tube structure. In a possible implementation, the distal end of the guide inner core 12 is a spring structure, and the proximal end of the guide inner core 12 is a metal tube structure.

[0057] In another embodiment, the distal end of the guide core 12 is a sea wave tube structure, a snake bone structure, a braided tube structure or a bellows structure to achieve the delivery of the guide core 12 in a curved or bifurcated anatomical structure and the bending adjustment function of the distal end of the ablation catheter assembly.

[0058] Optionally, the sheath is a metal and polymer composite multi-lumen structure with good bending performance; the polymer tube is preferably polyetheramide, nylon, thermoplastic polyurethane, polyimide, polytetrafluoroethylene, etc.

[0059] In a possible implementation, the distal end and the proximal end of the guide inner core 12 are manufactured in an integrated manner based on a complete tube through processes such as laser cutting. The distal end and the proximal end of the guide inner core 12 can also be manufactured in a separate manner through assembly methods such as welding, clamping or threading.

[0060] Furthermore, the ablation catheter assembly further includes a navigation wire, and the guide inner core 12 is a hollow structure, and the guide inner core 12 is used to accommodate the navigation wire. In this way, the guide inner core 12 is a hollow structure, which ensures that the navigation wire is stably accommodated and guided, and avoids its deviation due to external force or unstable factors, thereby improving the guidance accuracy of the navigation wire to the target lesion.

[0061] Specifically, the ablation catheter assembly includes a navigation line and a sensor connector, wherein the navigation line is electrically connected to the information collection device 13 , and the sensor connector is communicatively connected to the pulse ablation system. The navigation line is used to transmit the position information of the flexible electrode 11 .

[0062] Furthermore, the ablation catheter assembly includes an information collection device 13, which is connected to the flexible electrode 11 and is used to obtain position information of the flexible electrode 11 and / or morphological data of the flexible electrode 11. The information collection device 13 can monitor the position of the flexible electrode 11 in real time, ensure accurate positioning of the lesion during operation, reduce the risk of misoperation, and accurately understand the morphology and position of the flexible electrode 11, ensure that the electrode is in close contact with the target tissue, and improve the uniformity of energy transfer and ablation efficiency.

[0063] Specifically, the information collection device 13 is arranged on the fixing member 14, the distal end of the flexible electrode 11 is fixedly connected to the fixing member 14, the ablation catheter assembly includes a navigation line and a sensor connector, the navigation line is electrically connected to the information collection device 13, and the sensor connector is communicatively connected to the pulse ablation system. In the embodiment of this specification, the fixing member 14 is a fixing sleeve.

[0064] Specifically, the pulse ablation device can determine the relative position of the flexible electrode 11 and the target lesion tissue and patient structure in real time, avoid deviation in the delivery of the flexible electrode 11, improve positioning accuracy, reduce the frequency of intraoperative computed tomography (CT) confirmation, eliminate the need for repeated adjustments, reduce the possibility of serious complications, and improve safety.

[0065] In one embodiment, the information collection device 13 is a positioning sensor, which can be combined with an electromagnetic positioning three-dimensional navigation system; in another embodiment, the information collection device 13 is a morphology sensing optical fiber, which can monitor the morphology data of the flexible electrode in real time.

[0066] Specifically, when the information collection device 13 is a positioning sensor, the positioning sensor is connected to the electromagnetic positioning three-dimensional navigation system. The electromagnetic positioning three-dimensional navigation system can track the position of the flexible electrode in real time and display the coordinates of the flexible electrode in three-dimensional space. Then the operator adjusts the direction of the flexible electrode according to the position displayed in real time by the electromagnetic positioning three-dimensional navigation system to ensure that the flexible electrode can correctly contact the target lesion tissue position.

[0067] Furthermore, the ablation catheter assembly also includes a pulse cable 15 and a pulse connector. The distal end of the pulse cable 15 is connected to the flexible electrode 11, and the proximal end of the pulse cable 15 is placed in the pulse connector. The pulse cable 15 is connected to the pulse ablation system through the pulse connector. In this way, the pulse cable 15 can stably transmit high-frequency pulse energy to the flexible electrode 11, and can also integrate the bidirectional transmission of electrode monitoring signals to improve energy utilization and ablation efficiency.

[0068] Specifically, the pulse cable 15 is electrically connected to the flexible electrode 11, the ablation catheter assembly is connected to the pulse connector, the distal end of the pulse connector is connected to the ablation catheter assembly, the proximal end of the pulse connector is communicatively connected to the pulse ablation system, and a pulse connector is provided at the proximal end of the pulse connector.

[0069] Specifically, the first ablation catheter assembly 1 includes a first pulse cable 15 and a first pulse connector, and the second ablation catheter assembly 2 includes a second pulse cable 15 and a second pulse connector. The pulse ablation system can independently control the first ablation catheter assembly 1 and the second ablation catheter assembly 2.

[0070] Specifically, the pulse ablation device in the embodiment of the present specification includes a connector assembly 7, and the connector assembly 7 includes a sensor connector and a pulse connector.

[0071] Specifically, the adjustment component 5 includes an adjustment switch 51, a transmission mechanism and a fine-tuning knob 52. The fine-tuning knob 52 is connected to the adjustment switch 51 through the transmission mechanism. The adjustment switch 51 is used to switch the adjustment mode of the ablation catheter assembly. In the coarse adjustment mode, the ablation catheter assembly can reciprocate along the axial direction of the multi-lumen tube 3 in the multi-lumen tube 3. In the fine adjustment mode, the fine-tuning knob 52 can drive the ablation catheter assembly to reciprocate along the axial direction of the multi-lumen tube 3 through the transmission mechanism. In this way, the ablation catheter assembly can not only move rapidly and significantly along the axial direction of the multi-lumen tube 3, but also achieve fine axial movement through the transmission mechanism of the fine-tuning knob 52, so that the operator can flexibly respond to the operation requirements at different stages without changing instruments or complicated operations, which significantly improves the efficiency of the operation.

[0072] Specifically, the adjustment component 5 includes a Y-type valve. In the embodiment of the present specification, the adjustment component 5 includes a first adjustment switch 51, a first transmission mechanism, a first fine-tuning knob 52, a second adjustment switch 51, a second transmission mechanism and a second fine-tuning knob 52. The first adjustment switch 51, the first transmission mechanism and the first fine-tuning knob 52 are used to adjust the first ablation catheter component 1, and the second adjustment switch 51, the second transmission mechanism and the second fine-tuning knob 52 are used to adjust the second ablation catheter component 2.

[0073] Specifically, for the first ablation catheter assembly 1, in the coarse adjustment mode, the operator manually adjusts the position of the first ablation catheter assembly 1; in the fine adjustment mode, the operator first turns on the fine adjustment switch, and then turns the first fine adjustment knob 52. The first fine adjustment knob 52 and the first transmission mechanism are transmitted through a threaded structure, and through the meshing of the threads, the rotational power is transmitted to the first ablation catheter assembly 1 to make it produce linear motion. For the second ablation catheter assembly 2, in the coarse adjustment mode, the operator manually adjusts the position of the second ablation catheter assembly 2; in the fine adjustment mode, the operator first turns on the fine adjustment switch, and then turns the second fine adjustment knob 52. The second fine adjustment knob 52 and the second transmission mechanism are transmitted through a threaded structure, and through the meshing of the threads, the rotational power is transmitted to the second ablation catheter assembly 2 to make it produce linear motion.

[0074] Specifically, the rigidity of the distal end of the multi-lumen tube 3 is less than that of the proximal end of the multi-lumen tube 3. In this way, the distal end of the multi-lumen tube 3 has higher flexibility, which can adapt to the bending characteristics of the lungs or other complex anatomical areas, and helps the flexible electrode 11 to better fit the surface of the target lesion tissue, ensuring that the ablation energy can be released evenly and accurately, thereby improving the treatment effect.

[0075] Specifically, the multi-lumen tube 3 and at least two groups of ablation catheter components can be delivered via bronchoscope intervention for the treatment of natural cavity diseases. The multi-lumen tube 3 is a metal and polymer composite multi-lumen structure, and the rigidity of the multi-lumen tube 3 gradually decreases from the proximal end to the distal end.

[0076] Preferably, the metal material in the multi-lumen tube 3 is medical stainless steel or nickel-titanium alloy or the like; the polymer material is polyetheramide, nylon, thermoplastic polyurethane, polyimide or polytetrafluoroethylene or the like.

[0077] Specifically, the outer diameter of the multi-lumen tube 3 is 1 mm to 4 mm. In this way, the multi-lumen tube 3 can accommodate at least two groups of ablation catheter components and can also cooperate with the lung lesion tissue channel. The multi-lumen tube 3 can accurately reach the target area, ensuring that the ablation catheter directly acts on the lesion tissue, and improving the reliability and stability of the overall treatment.

[0078] Specifically, the outer diameter of the multi-lumen tube 3 is smaller than the inner diameter of the target lesion tissue channel, and the outer diameter of the multi-lumen tube 3 is larger than the sum of the inner diameters of at least two groups of ablation catheters.

[0079] Preferably, the wall thickness of the multi-lumen tube 3 is 0.025 mm-0.1 mm.

[0080] The following describes the working process of the multi-channel pulse ablation device in combination with specific application scenarios:

[0081] First, the first ablation catheter assembly 1 and the second ablation catheter assembly 2 are inserted into the multi-lumen tube 3;

[0082] Then, the multi-lumen tube 3 is pushed through the working channel of the bronchoscope and gradually enters the target lesion tissue position. The electromagnetic positioning technology is used to track the positions of the first flexible electrode and the second flexible electrode in real time, determine the position of each flexible electrode 11 relative to the bronchial anatomical structure, and guide each flexible electrode 11 to quickly reach the target lesion tissue position along the optimal navigation path;

[0083] Afterwards, if the position of the ablation electrode needs to be precisely adjusted, adjust the adjustment switch 51 on the handle assembly, switch the adjustment assembly 5 to the fine-tuning mode, and use the fine-tuning knob 52 to perform subtle displacement operations on each ablation catheter assembly to ensure that each flexible electrode 11 is accurately docked with the target lesion tissue position.

[0084] Finally, after the positioning is completed, the target lesion tissue position is activated to treat the lesion site so that the pulse energy ablates the target lesion tissue.

[0085] The above are only preferred embodiments of the present application and are not intended to limit the present application. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present application should be included in the protection scope of the present application.

Claims

1. A multi-channel pulse ablation device, applied to a lung lesion tissue channel, wherein the outer diameter of the pulse ablation device is smaller than the inner diameter of the lung lesion tissue channel, characterized in that: The pulse ablation device comprises a multi-lumen tube, an adjustment component, at least two groups of ablation catheter components and flexible electrodes corresponding to each group of ablation catheter components; The multi-lumen tube is used to accommodate the at least two groups of ablation catheter assemblies, the adjustment assembly is connected to each group of the ablation catheter assemblies, and the ablation catheter assemblies are connected to the flexible electrodes; The at least two groups of ablation catheter assemblies are capable of moving along the axial direction of the multi-lumen tube, and the adjustment assembly is used to adjust the position of each group of ablation catheter assemblies to adjust the position of the flexible electrode.

2. The multi-channel pulse ablation device according to claim 1, characterized in that: The pulse ablation device also includes a bending adjustment member (4) and a bending adjustment valve; The bending adjusting member (4) is arranged between the multi-lumen tube (3) and the at least two groups of ablation catheter components, and the bending adjusting member (4) is connected to the bending adjusting valve; The bending regulating valve can adjust the curvature of the bending regulating member (4) to adjust the curvature of the at least two groups of ablation catheter assemblies.

3. The multi-channel pulse ablation device according to claim 1, characterized in that: The ablation catheter assembly comprises a guide inner core (12) and a handle assembly (6); The guide inner core (12) is arranged between the flexible electrode (11) and the handle assembly (6); the handle assembly (6) is transmission-connected to the proximal end of the guide inner core (12); and the distal end of the guide inner core (12) is elastically connected to the flexible electrode (11).

4. The multi-channel pulse ablation device according to claim 3, characterized in that: The rigidity of the distal end of the guide inner core is smaller than the rigidity of the proximal end of the guide inner core.

5. The multi-channel pulse ablation device according to claim 3 or 4, characterized in that: The ablation catheter assembly also includes a navigation wire. The guide inner core (12) is a hollow structure, and the guide inner core (12) is used to accommodate the navigation wire.

6. The multi-channel pulse ablation device according to any one of claims 1 to 4, characterized in that: The ablation catheter assembly comprises an information collecting device (13), wherein the information collecting device (13) is connected to the flexible electrode (11), and the information collecting device (13) is used to obtain position information of the flexible electrode (11) and / or morphological data of the flexible electrode (11).

7. The multi-channel pulse ablation device according to any one of claims 1 to 4, characterized in that: The ablation catheter assembly also includes a pulse cable (15) and a pulse connector, wherein the distal end of the pulse cable (15) is connected to the flexible electrode (11), the proximal end of the pulse cable (15) is placed in the pulse connector, and the pulse cable (15) is connected to the pulse ablation system via the pulse connector.

8. The multi-channel pulse ablation device according to any one of claims 1 to 4, characterized in that: The adjustment component (5) comprises an adjustment switch (51), a transmission mechanism and a fine-tuning knob (52); the fine-tuning knob (52) is connected to the adjustment switch (51) via the transmission mechanism; and the adjustment switch (51) is used to switch the adjustment mode of the ablation catheter component; In the coarse adjustment mode, the ablation catheter assembly can reciprocate in the multi-lumen tube (3) along the axial direction of the multi-lumen tube (3); In the fine-tuning mode, the fine-tuning knob (52) can drive the ablation catheter assembly to move back and forth along the axial direction of the multi-lumen tube (3) through the transmission mechanism.

9. The multi-channel pulse ablation device according to any one of claims 1 to 4, characterized in that: The rigidity of the distal end of the multi-lumen tube (3) is smaller than the rigidity of the proximal end of the multi-lumen tube (3).

10. The multi-channel pulse ablation device according to any one of claims 1 to 4, characterized in that: The outer diameter of the multi-lumen tube (3) is 1 mm-4 mm.

Images