Calibration equipment and calibration method for ultra-high dose rate radiation device and ultra-high dose rate radiation device

Abstract

The present disclosure provides a calibration device for an ultrahigh dose rate radiation device, the ultrahigh dose rate radiation device comprising a plurality of beam modules for emitting a plurality of radiation beams, the calibration device comprising: a calibration target assembly comprising a target portion, the target part is located in a preset radiation area of the ultrahigh dose rate radiation device in the calibration process; wherein the target part is used as a reference to calibrate the intersection deviation of the plurality of radiation beams in the predetermined radiation area. The invention also provides a calibration method and an ultrahigh dose rate radiation device.

Description

Technical Field

[0001] The present disclosure relates to the field of radiotherapy, specifically to the field of flash therapy, and more specifically to calibration equipment and a calibration method for an ultra-high dose rate radiation device and an ultra-high dose rate radiation device. Background Art

[0002] Ultra-high dose rate includes a dose rate of more than 40Gy / s in a short period of time, for example, an average dose rate of more than 300Gy / s, which can be applied to medical radiotherapy, container security inspection, industrial imaging and other fields.

[0003] Take flash therapy as an example, which is also called ultra-high dose rate radiotherapy (FLASH-RT), a treatment option for tumor radiotherapy. Flash therapy technology not only kills tumor cells, but also has low toxic side effects on normal tissues, and reduces the risk of damage to the patient's body by taking a large amount of rejection drugs after surgery, while shortening the postoperative recovery period and improving the quality of life after surgery.

[0004] In the process of realizing the inventive concept of the present disclosure, the inventors found that how to perform multi-angle ultra-high dose rate radiation on a designated location within a short period of time (such as within hundreds of milliseconds) is a problem that needs to be solved urgently. Summary of the invention

[0005] In view of the above problems, the present disclosure provides a calibration device, a calibration method and an ultra-high dose rate radiation device for an ultra-high dose rate radiation device.

[0006] According to a first aspect of the present disclosure, a calibration device for an ultra-high dose rate radiation device is provided, wherein the ultra-high dose rate radiation device comprises a plurality of beam modules for emitting a plurality of radiation beams, and the calibration device comprises: a calibration target assembly, comprising a target portion, wherein the target portion is located in a predetermined radiation area of ​​the ultra-high dose rate radiation device during a calibration process; wherein the target portion is used as a reference to calibrate an intersection deviation of the plurality of radiation beams converging in the predetermined radiation area.

[0007] In some embodiments, the multiple beam modules are installed on the rotating drum of the ultra-high dose rate radiation device, and the target portion is located in the predetermined radiation area of ​​the ultra-high dose rate radiation device during the calibration process, including: during the calibration process, the center of the target portion is located at the rotation axis of the rotating drum.

[0008] In some embodiments, the calibration device further includes: a plurality of laser components, which are installed one by one at the beam emission positions of the plurality of beam modules; wherein the plurality of laser components are used to emit a plurality of laser beams to the target portion to simulate the intersection position where the plurality of radiation beams converge at the predetermined radiation area.

[0009] In some embodiments, the target portion comprises: a sphere, wherein during the calibration process, the center of the sphere is located at the rotation axis of the rotating drum.

[0010] In some embodiments, the sphere is drawn with interwoven longitudes and latitudes, wherein the longitudes and latitudes are used to characterize the intersection deviation between any two laser beams among the multiple laser beams.

[0011] In some embodiments, the multiple beam modules are distributed in a ring around the rotating drum, and the sphere is used as a reference to guide the multiple laser beams to converge on the surface of the sphere.

[0012] In some embodiments, the radius of the sphere is less than or equal to a predetermined threshold, and the center of the sphere coincides with the target point position in the predetermined radiation area, wherein the predetermined threshold is used to constrain the error between the impact position of any laser beam and the target radiotherapy position.

[0013] In some embodiments, the calibration target assembly also includes a support frame, which includes: a base, installed on the inner wall of the rotating drum, the curvature of the bottom surface of the base matches the curvature of the installation area located on the inner wall of the rotating drum; a connecting member, a first end of which is connected to the base, and a second end of which is connected to the sphere.

[0014] In some embodiments, the distances between the beam emission positions of the plurality of beam modules and the target portion are substantially equal.

[0015] In some embodiments, the target portion includes: at least one dose detection module, used to detect a first actual dose of the radiation beam emitted by each beam module; wherein the difference between the first actual dose and the first theoretical dose of the radiation beam emitted by each beam module is used to characterize the intersection deviation.

[0016] In some embodiments, the at least one dose detection module includes: at least one dosimeter for detecting a first actual dose of the radiation beam emitted by each beam module.

[0017] In some embodiments, the at least one dosimeter includes multiple dosimeters, the multiple beam modules are distributed in a ring around the rotating drum of the ultra-high dose rate radiation device, and the multiple radiation detection areas of the multiple dosimeters are distributed in a ring to correspond one-to-one to the multiple beam emission positions of the multiple beam modules; wherein the multiple dosimeters are used to detect the first actual dose of each radiation beam in the multiple radiation beams in a one-to-one correspondence.

[0018] In some embodiments, the at least one dose detection module includes: at least one ionization chamber, used to detect a second actual dose of the radiation beam emitted by each beam module; wherein the difference between the second actual dose and the first theoretical dose of the radiation beam emitted by each beam module is used to characterize the intersection deviation.

[0019] In some embodiments, the at least one ionization chamber includes a plurality of ionization chambers, the plurality of beam modules are distributed in a ring around the rotating drum of the ultra-high dose rate radiation device, the plurality of ray incident angles of the plurality of ionization chambers correspond one-to-one to the plurality of beam emission positions of the plurality of beam modules, so as to receive the plurality of radiation beams one-to-one; wherein the plurality of ionization chambers are used to detect the second actual dose of each of the plurality of radiation beams one-to-one.

[0020] Another aspect of an embodiment of the present disclosure provides a calibration method for an ultra-high dose rate radiation device, wherein the ultra-high dose rate radiation device includes multiple beam modules for emitting multiple radiation beams, and the calibration method includes: during the calibration process, arranging the target of the calibration target assembly in a predetermined radiation area of ​​the ultra-high dose rate radiation device; and using the target portion as a reference to calibrate the intersection deviation of the multiple radiation beams converging in the predetermined radiation area.

[0021] Another aspect of an embodiment of the present disclosure provides an ultra-high dose rate radiation device, comprising: a rotating drum; a plurality of beam modules for emitting multiple radiation beams, wherein the multiple beam modules are distributed in a ring around the rotating drum; wherein the multiple beam modules are configured to be calibrated by a calibration device as described in any one of the above items so as to converge the multiple radiation beams into a predetermined radiation area.

[0022] One or more of the above embodiments have the following beneficial effects: providing a calibration target assembly, using its target portion as a reference to calibrate the intersection deviation of the multiple radiation beams at the predetermined radiation area, so that the multiple radiation beams can be converged in the predetermined radiation area, and the intersection deviation meets the expected requirements. It is possible to enable the calibrated multiple beam modules to perform ultra-high dose rate radiation on the same designated position at multiple angles. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] The above contents and other objects, features and advantages of the present disclosure will become more apparent through the following description of the embodiments of the present disclosure with reference to the accompanying drawings, in which:

[0024] Figure 1 A partial structural diagram of an ultra-high dose rate radiation device according to an embodiment of the present disclosure is schematically shown;

[0025] Figure 2 The structure diagram of the calibration target assembly according to an embodiment of the present disclosure is schematically shown, wherein: Figure 2 (a) is the main view of the calibration target assembly. Figure 2 (b) is a side view of the calibration target assembly;

[0026] Figure 3 The structure cross-sectional view of the rotary drum and the calibration target assembly according to the embodiment of the present disclosure is schematically shown;

[0027] Figure 4 The structure top view of the rotary drum and the calibration target assembly according to the embodiment of the present disclosure is schematically shown;

[0028] Figure 5 Schematically shows an installation zero position state diagram according to an embodiment of the present disclosure;

[0029] Figure 6 The flowchart of the calibration method according to the embodiment of the present disclosure is schematically shown.

[0030] The reference numerals used in the above drawings include:

[0031] 100. Ultra-high dose rate radiation device; 110. Beam assembly; 111. First beam module; 112. Second beam module; 113. Third beam module; 114. Fourth beam module; 115. Fifth beam module; 120. Rotating drum; 130. Calibration target assembly; 131. Sphere; 132. Base; 133. Connector; 140. Mounting support; 141. First support; 142. Second support; 510. Slot; 520. Positioning screw.

[0032] It should be noted that, for the sake of clarity, in the drawings used to describe the embodiments of the present disclosure, the sizes of the overall / local structures or the overall / local areas may be enlarged or reduced, that is, these drawings are not drawn according to the actual scale. DETAILED DESCRIPTION

[0033] Hereinafter, embodiments of the present disclosure will be described with reference to the accompanying drawings. However, it should be understood that these descriptions are exemplary only and are not intended to limit the scope of the present disclosure. In the following detailed description, for ease of explanation, many specific details are set forth to provide a comprehensive understanding of the embodiments of the present disclosure. However, it is apparent that one or more embodiments may also be implemented without these specific details. In addition, in the following description, descriptions of known structures and technologies are omitted to avoid unnecessary confusion of the concepts of the present disclosure.

[0034] Figure 1 The partial structure diagram of the ultra-high dose rate radiation device 100 according to the embodiment of the present disclosure is schematically shown. Figure 2 The structure diagram of the calibration target assembly 130 according to an embodiment of the present disclosure is schematically shown. Figure 2(a) is a front view of the calibration target assembly 130, Figure 2 (b) is a side view of the calibration target assembly 130 .

[0035] like Figure 1 As shown, the ultra-high dose rate radiation device 100 includes a beam assembly 110, a rotary drum 120 and a mounting support 140. The beam assembly 110 may include a plurality of beam modules for emitting a plurality of radiation beams, for example, a first beam module 111, a second beam module 112, a third beam module 113, a fourth beam module 114 and a fifth beam module 115. The mounting support 140 may include a first support 141 and a second support 142. The first beam module 111, the second beam module 112 and the third beam module 113 may be mounted on the first support 141, and the fourth beam module 114 and the fifth beam module 115 may be mounted on the second support 142.

[0036] For example, the ultra-high dose rate radiation device 100 involved in the present disclosure is used to generate a radiation beam that can be used in fields such as radiotherapy, container security inspection and industrial imaging, and can achieve ultra-high dose rate (for example, above 40Gy / s) radiation transfer, thereby completing the desired radiation in a very short time.

[0037] Figure 1 1 shows a schematic location of the calibration device, which can be located inside the rotating drum 120. In some embodiments, the calibration device includes a calibration target assembly 130. The calibration target assembly 130 includes a target portion, wherein the target portion is located in a predetermined radiation area of ​​the ultra-high dose rate radiation device 100 during the calibration process; wherein the target portion is used as a reference to calibrate the intersection deviation of multiple radiation beams converging in the predetermined radiation area.

[0038] For example, the beam module may include a linear accelerator. The radiation beam may include an X-ray beam. The predetermined radiation area may be an area in the ultra-high dose rate radiation device 100 where radiotherapy is allowed, for example, the rotary drum 120 has a receiving space that can accommodate the target object to be radiotherapy. The predetermined radiation area may be a fixed area in the receiving space, for example, the lesion of the patient to be radiotherapy is placed in the fixed area and then receives radiotherapy.

[0039] In some embodiments, the ultra-high dose rate radiation device 100 may include one or more predetermined radiation areas. When the ultra-high dose rate radiation device 100 includes multiple predetermined radiation areas, multiple calibration devices may be provided to provide calibration functions simultaneously or asynchronously, or a single calibration device may be provided to provide calibration functions by changing positions between multiple predetermined radiation areas.

[0040] In some embodiments, the distances between the beam emission positions of the multiple beam modules and the target portion are substantially equal, which is beneficial for making the radiation effects of the beam modules on the radiotherapy area substantially consistent and also beneficial for the accuracy of calibration.

[0041] Exemplarily, the rotary drum 120 can rotate around its rotation axis, thereby driving the first beam module 111, the second beam module 112, the third beam module 113, the fourth beam module 114 and the fifth beam module 115 to rotate. For example, during the calibration process, the center of the target portion is located at the rotation axis of the rotary drum 120. Therefore, during the rotation process, the rotary drum 120 can rotate around the predetermined radiation area. During the rotation process, by switching different beam modules to emit beams, the same predetermined radiation area (such as a lesion) can be irradiated at different angles, wherein the radiation beam emitted by each beam module can achieve the effect of ultra-high dose rate radiation. Multiple beam modules can emit beams in order and in relative position to the predetermined radiation area, or in a disordered order. Even when necessary, beams can be emitted for treatment at the same time.

[0042] By arranging a plurality of beam modules (such as an accelerating tube or an X-ray tube or other radiation generating devices) at different angles on a rotatable rotary drum 120, the beam modules generating radiation are switched to achieve the purpose of rapidly performing multiple angle irradiation treatment in a very short time required in flash radiotherapy. That is, after calibration is completed, the cooperation of the rotary drum 120 and the plurality of beam modules can achieve ultra-high dose rate irradiation of a predetermined radiation area at multiple angles.

[0043] The target as a reference means that by simulating the beam output of multiple beam modules, a simulated radiation beam can be used as a reference to guide the simulated radiation beam to hit the predetermined radiation area, or multiple beam modules can be made to actually output beams, which can be used as a reference to guide multiple actual beams to hit the predetermined radiation area.

[0044] Whether the target is hit by a simulated radiation beam or by an actual beam, the situation where multiple radiation beams converge in a predetermined radiation area can be characterized in a visual or non-visual manner. Non-visual methods may include data processing methods such as signal detection or dose detection. By characterizing in a visual or non-visual manner, the intersection deviation of multiple radiation beams in a predetermined radiation area can be calibrated. The intersection deviation includes the distance between the impact position of any radiation beam in the predetermined radiation area and a specific position, or the distance between the impact positions of any two radiation beams in the predetermined radiation area.

[0045] In some embodiments, the target portion is used as a reference to calibrate the intersection deviation of multiple beam modules in a predetermined radiation area, including at least one of the following:

[0046] Simulate multiple beam modules to emit beams through multiple beams of visible light, simulate multiple radiation beams hitting the target, and manually test or image-recognize the hitting positions and intersection deviations of multiple beams of visible light in a visual manner;

[0047] The radiation beam is actually emitted through multiple beam modules, and the dose of the radiation beam in the predetermined radiation area is detected by a dose detection method, and the intersection deviation is calibrated by the difference between the radiation beam doses;

[0048] The beam is actually emitted through multiple beam modules, and the ray signal of the radiation beam in the predetermined radiation area is detected by means of ray signal detection. The intersection deviation is calibrated by the representation of ray energy, ray quantity or radiation scanning image.

[0049] It can be understood that the above-mentioned method of simulating the beam emission of multiple beam modules, the dose detection method and the radiation signal detection method can be used one by one or in sequence.

[0050] According to an embodiment of the present disclosure, a calibration target assembly 130 is provided, and its target portion is used as a reference to calibrate the intersection deviation of multiple radiation beams at a predetermined radiation area, so that the multiple radiation beams can be converged at the predetermined radiation area, and the intersection deviation meets the expected requirements. It is possible to enable multiple calibrated beam modules to perform ultra-high dose rate radiation at multiple angles on the same designated position.

[0051] Various embodiments of using the target portion as a reference to calibrate the intersection deviation of multiple beam modules in a predetermined radiation area are further described below.

[0052] In some embodiments, the calibration device further comprises a plurality of laser assemblies, which are mounted one by one at the beam emission positions of the plurality of beam modules, wherein the plurality of laser assemblies are used to emit a plurality of laser beams to the target portion to simulate the intersection position of the plurality of radiation beams at the predetermined radiation area.

[0053] Each laser assembly is installed at the beam emission position of the corresponding beam module, and the installation axis coincides with the beam axis of the corresponding beam module for adjustment and positioning during installation. After the calibration is completed, the laser assembly can be removed.

[0054] For example, the intersection position includes the area where multiple laser beams converge at the target, which includes one or more points hit by each laser beam. The intersection deviation between the laser beams can be reflected by the distance between the points of each laser beam, or the distance between the point of each laser beam and the target point. When the intersection deviation does not meet the requirements, one or more of the angle, height, position, collimation parameters, etc. of the beam module can be adjusted, and then multiple laser components can be reused to emit multiple laser beams to the target.

[0055] According to an embodiment of the present disclosure, by providing a laser component to simulate the emission of multiple radiation beams, the intersection deviation can be efficiently measured in a low-cost and visual manner, and it can be quickly discovered whether the intersection position meets the conditions and then determine whether to adjust the beam module.

[0056] For example, the target portion may include a structure such as a plane mirror, a polygonal mirror, a plate, a cube, or a sphere, which can display the impact point of each laser beam in a visual manner.

[0057] For example, in the case where the target portion includes a single plane mirror or a flat plate, a target point can be marked thereon, and the laser assembly corresponding to the first beam module 111 is first moved to a specific position and then emits a laser to the target portion, and the position of its hit point is recorded. Then, by rotating the rotary drum 120, each of the remaining beam modules is moved to the same position in turn, and the corresponding laser assembly emits a laser and then records the position of the hit point. After obtaining the hit point positions of all laser assemblies, the distance between each hit point and the target point, as well as the distance between the hit points, can be calculated.

[0058] For example, when the target portion includes a polygonal mirror, it may include a prism structure formed by multiple plane mirrors. Multiple laser assemblies are made to emit lasers to the polygonal mirror at the same time to simulate the situation where multiple beam modules emit beams at the same time. The intersection deviation is measured by the impact point of each laser beam presented by the polygonal mirror.

[0059] For example, when the target portion includes a cube, it may be a cube, a cuboid, or other polyhedrons. Multiple laser assemblies are made to emit lasers to the cube at the same time to simulate the situation where multiple beam modules emit beams at the same time. The intersection deviation is measured by the impact point of each laser beam presented by the cube.

[0060] For example, in the case where the target portion includes a sphere 131 , further description will be given below.

[0061] In some embodiments, the center of the sphere 131 is located at the rotation axis of the rotating drum 120 during the calibration process.

[0062] The rotary drum 120 can rotate around its rotation axis and can rotate around a predetermined radiation area during the rotation process. Ideally, the rotary drum 120 always rotates around the same treatment center, and multiple beam modules are no longer calibrated during this process. The same treatment center can be the center position of the predetermined radiation area, and the center position is simulated by the center of the sphere. The sphere 131 can occupy part or all of the predetermined radiation area.

[0063] According to the embodiments of the present disclosure, by placing the center of the sphere on the axis of rotation, an actual radiotherapy scenario can be simulated, calibration accuracy can be improved, data deviation can be reduced, and the accuracy and consistency of the calibration process and the actual radiotherapy process can be maintained.

[0064] In some embodiments, the sphere 131 is drawn with interwoven longitude and latitude lines, wherein the longitude and latitude lines are used to represent the intersection deviation between any two laser beams in the multiple laser beams.

[0065] The longitude and latitude lines on the sphere 131 can be used as a reference grid for detecting and adjusting the alignment of the laser beams. For example, if two laser beams should intersect at one point on the sphere 131, but actually the grid shows them intersecting at different points, this deviation can be corrected by adjusting the position or angle of the laser emitters.

[0066] According to an embodiment of the present disclosure, the longitude and latitude lines provide a visual framework for accurately measuring the intersection deviation of each laser beam and visually simulating and displaying the intersection position.

[0067] In some embodiments, Figure 1 The multiple beam modules shown are distributed in a ring around the rotary drum 120, and the sphere 131 is used as a reference to guide the multiple laser beams to converge on the surface of the sphere. Further, the impact points of the multiple laser beams on the sphere 131 can be guided to be located on the same circular cross section.

[0068] Multiple beam modules are evenly distributed around the rotating drum 120, and can emit radiation beams from different angles simultaneously or asynchronously. By calibrating so that the impact points of all laser beams on the sphere 131 are located on the sphere 131, the expected intersection position can be obtained by emitting multiple radiation beams during the actual radiotherapy process. Maintaining the same circular cross-section is conducive to achieving the proximity of the impact position and thus achieving the flash therapy radiation effect of ultra-high dose rate.

[0069] In some embodiments, the radius of the sphere 131 is less than or equal to a predetermined threshold, and the center of the sphere 131 coincides with the target point position in the predetermined radiation area, wherein the predetermined threshold is used to constrain the error between the impact position of any laser beam and the target radiotherapy position.

[0070] By controlling the radius and the center position of the sphere 131, the irradiation range of the laser beam can be controlled, that is, when any laser beam can irradiate the sphere 131, the distance between its impact point and the center of the sphere is equal to the predetermined threshold, and thus is less than the error value equal to the predetermined threshold. When the predetermined threshold is less than or equal to the predetermined error value, it is quickly confirmed in a visual manner which laser beams meet the intersection deviation because they irradiate the sphere 131, and which laser beams do not meet the intersection deviation because they do not irradiate the sphere 131, so as to adjust the beam modules corresponding to the laser beams that do not meet the intersection deviation.

[0071] For example, the predetermined threshold value or the predetermined error value may be determined according to the size of the lesion to be irradiated.

[0072] Therefore, the sphere 131 can be used to realize the beam convergence center of multiple beam modules (such as multiple linear accelerators) in the geometric space, and the error between each radiation beam and the intersection point is less than a predetermined error value, such as ±5mm, thereby achieving ultra-high dose irradiation at the designated lesion location.

[0073] Exemplarily, the sphere 131 may be made of plastic, iron, lead or stainless steel, and its diameter may be 10 mm (for example only), the coaxial error between the sphere center and the rotation axis is ≯0.2 mm, and the processing error is ensured by fine processing of CNC machine tools.

[0074] As Figure 2 As shown, the calibration target assembly 130 also includes a support frame. The support frame includes: a base 132, which is installed on the inner wall of the rotary drum 120, and the curvature of the bottom surface of the base 132 matches the curvature of the installation area on the inner wall of the rotary drum 120; a connecting member 133, whose first end is connected to the base 132 and whose second end is connected to the sphere 131.

[0075] Among them, the bottom surface of the base 132 serves as the component installation surface, which fits with the inner wall curved surface of the rotary drum 120 (that is, the curvature matches), and is conveniently installed on the inner circle (inner wall arc surface) of the rotary drum 120. The inner circle installation position is finely machined, and the processing error is guaranteed by fine machining of CNC machine tools.

[0076] The following further describes the actual beam emission through multiple beam modules, the use of dose detection to detect the dose of the radiation beam in a predetermined radiation area, and the calibration of the intersection deviation through the difference between the radiation beam doses.

[0077] In some embodiments, the target portion includes at least one dose detection module for detecting a first actual dose of the radiation beam emitted by each beam module; wherein the difference between the first actual dose and the first theoretical dose of the radiation beam emitted by each beam module is used to characterize the intersection deviation.

[0078] It can be understood that when multiple beam modules can intersect in a predetermined radiation area, and the intersection deviation is less than a certain value, the dose of the radiation beam emitted by each beam module in the predetermined radiation area can be estimated, which is called the first theoretical dose. Therefore, the intersection deviation can be reflected by the difference between the actual detection dose and the theoretical dose. For example, it can be estimated that there is a certain deviation between the distance between the radiation beam emitted by each beam module and the target point.

[0079] According to the embodiments of the present disclosure, an accurate comparison between the actual dose and the theoretical dose of the radiation beam emitted by each beam module can be achieved, thereby effectively characterizing the intersection deviation, which can not only improve the calibration efficiency and reliability, but also improve the dose accuracy and consistency of radiotherapy.

[0080] In some embodiments, at least one dose detection module includes at least one dosimeter for detecting a first actual dose of the radiation beam emitted by each beam module.

[0081] A dosimeter is a device used to measure the dose of radiation (such as X-rays and gamma rays). For example, the radiation intensity can be measured based on a radiation-sensitive detector, that is, when radiation particles in the environment pass through the detector, they will react with the radiation-sensitive medium, which will then be collected by the detector and converted into an electrical signal. The electrical signal is further processed to calculate the radiation dose.

[0082] For example, at least one dosimeter may include a single dosimeter whose radiation detection area has a fixed angle. By rotating the rotating drum 120, each beam module is rotated to the same angle in turn, and a radiation beam is emitted to the radiation detection area of ​​the dosimeter serving as the target, thereby realizing dose detection of multiple radiation beams.

[0083] In some embodiments, at least one dosimeter includes multiple dosimeters, multiple beam modules are distributed in a ring around the rotating drum 120 of the ultra-high dose rate radiation device 100, and multiple radiation detection areas of the multiple dosimeters are distributed in a ring to correspond one-to-one to multiple beam emission positions of the multiple beam modules; wherein the multiple dosimeters are used to detect the first actual dose of each radiation beam in the multiple radiation beams in a one-to-one correspondence.

[0084] For example, the radiation detection area is used to reflect the radiation and measure the radiation dose passing through the area. Multiple dosimeters are independent dose detection devices.

[0085] According to the embodiments of the present disclosure, the dose of each beam module can be accurately measured, so that the intersection deviation between each beam module and the target point or other beam modules can be accurately evaluated.

[0086] In some embodiments, at least one dose detection module includes: at least one ionization chamber for detecting a second actual dose of the radiation beam emitted by each beam module; wherein the difference between the second actual dose and the first theoretical dose of the radiation beam emitted by each beam module is used to characterize the intersection deviation.

[0087] The ionization chamber contains a chamber filled with inert gas, with positive and negative electrodes in the chamber. When radiation is incident, it causes the gas in the tube to ionize. Under the action of the electric field, electrons move toward the anode and positive ions move toward the cathode. The electrons collected by the anode form a current in the circuit and are recorded, thereby measuring the radiation dose.

[0088] For example, at least one ionization chamber may include a single ionization chamber whose radiation detection area has a fixed angle. By rotating the rotating drum 120, each beam module is rotated to the same angle in turn, and a radiation beam is emitted to the radiation detection area of ​​the ionization chamber serving as a target, thereby realizing dose detection of multiple radiation beams.

[0089] In some embodiments, at least one ionization chamber includes multiple ionization chambers, multiple beam modules are distributed in a ring around the rotating drum 120 of the ultra-high dose rate radiation device 100, and multiple ray incident angles of the multiple ionization chambers correspond one-to-one to multiple beam emission positions of the multiple beam modules to receive multiple radiation beams one-to-one; wherein the multiple ionization chambers are used to detect the second actual dose of each radiation beam in the multiple radiation beams one-to-one.

[0090] Figure 3 The structural cross-sectional view of the rotary drum 120 and the calibration target assembly 130 according to an embodiment of the present disclosure is schematically shown. Figure 4 The structure top view of the rotary drum 120 and the calibration target assembly 130 according to an embodiment of the present disclosure is schematically shown. Figure 5 The diagram schematically shows the installation zero position state according to an embodiment of the present disclosure. The installation zero position is the initial state of the beam module installation.

[0091] Reference Figure 1 , Figure 2 , Figure 3 , Figure 4 and Figure 5 , the following describes the beam module installation and calibration process of the ultra-high dose rate radiation device 100.

[0092] When the rotary drum 120 is installed, the first beam module 111, the second beam module 112, and the third beam module 113 are installed on the upper first support 141, and the fourth beam module 114 and the fifth beam module 115 are installed on the lower second support 142 on the working platform. The upper beam support is lifted by a sling and docked with the rotary drum 120 assembly, and fixed with a fixing pin and fastened with a screw; then the motor drum is driven to rotate 180°, and the lower beam module support is docked with the rotary drum 120 assembly, and fixed with a pin and fastened, and then the drum is rotated back to the working zero position.

[0093] Among them, Figure 5 The first support 141 and the second support 142 include a slot 510 for installing the beam module. The mounting surfaces of the first support 141 and the second support 142 are coplanar, and the distance control error between the surface and one end surface of the drum is ≯0.2mm. A plurality of positioning screws 520 are reserved near the slot 510 to meet the front-back, left-right and four-way adjustment functions, which is conducive to observing the positioning reference and adjusting the beam module during installation.

[0094] In order to facilitate installation and maintenance, multiple beam modules are modularly designed, which not only shortens the processing cycle, but also makes it easy to match with external interfaces and enhance interchangeability. The first support 141 or the second support 142 is made of aluminum and designed as an integrated structure, which minimizes weight while ensuring support strength and rigidity; the center hole of the acceleration tube mounting flange of the beam module is finely processed, and the tolerance between the center line of the hole and the bottom surface of the installed support 140 is controlled to be ≯0.05mm to ensure the consistency of the beam center line height of each module.

[0095] A calibration target assembly 130 is set on the central axis of the rotary drum 120, and its target part includes a sphere 131. The sphere 131 is made of stainless steel, and the diameter of the sphere 131 is 10mm. It is installed on the rotating axis of the rotary drum 120. The coaxial error between the sphere center and the rotating axis is ≯0.2mm. The bottom surface of the support frame is in a curved fit with the inner wall of the rotary drum. The processing error is ensured by fine processing of CNC machine tools. Figure 3 and Figure 4 The calibration target assembly 130 is adjustable in the front-to-rear direction along the rotation axis of the rotary drum 120 so that the center of the sphere 131 coincides with the intersection of the five radiation beams, which can meet the installation and adjustment of the on-site beam module.

[0096] With the calibration target assembly 130 as the positioning reference, the positions of the beam modules are adjusted in sequence by setting the positioning screws 520 of each slot 510 on the first support 141 and the second support 142. The beam modules can be fastened after the laser beams at the front end of each beam module are irradiated on the spherical surface and the multiple laser beams are roughly located on the same circular cross section (as far as possible at the cross section of the sphere center).

[0097] Among them, a sphere 131 is provided for calibration, and its center coincides with the rotation axis of the rotary drum 120. The sphere 131 serves as a reference target for the beam convergence center of each beam module, and can be used for multi-directional adjustment and positioning installation of the beam module, and multiple beam modules are installed sequentially, and finally the beam convergence center of multiple beam modules distributed in an array is realized.

[0098] Based on the calibration device for the ultra-high dose rate radiation device 100 as described above, a calibration method is also provided, which is further described below.

[0099] Figure 6 The flowchart of the calibration method according to the embodiment of the present disclosure is schematically shown.

[0100] like Figure 6 As shown, the calibration method of this embodiment includes the following contents:

[0101] In operation S610 , during the calibration process, a target of the calibration target assembly 130 is arranged in a predetermined radiation area of ​​the ultra-high dose rate radiation device 100 ;

[0102] In operation S620 , a convergence deviation of a plurality of radiation beams converging at a predetermined radiation area is calibrated using the target portion as a reference.

[0103] The calibration process involved in the present disclosure, for example, starts with the installation of each beam module and ends with the intersection deviation meeting the expected requirements. The expected requirements, for example, include making multiple laser beams hit the sphere 131, and the radius of the sphere 131 is less than or equal to a specific error, such as 5 mm.

[0104] In some embodiments, during the calibration process, the center of the target portion is located at the rotation axis of the rotating drum 120 .

[0105] In some embodiments, a plurality of laser assemblies are controlled to emit a plurality of laser beams to a target portion to simulate a convergence position where a plurality of radiation beams converge at a predetermined radiation region.

[0106] In some embodiments, the target portion includes a sphere 131 , and the center of the sphere 131 is located at the rotation axis of the rotating drum 120 during the calibration process.

[0107] In some embodiments, the intersection deviation between any two laser beams among the multiple laser beams is represented by the interweaving longitude and latitude lines on the sphere 131 .

[0108] In some embodiments, the sphere 131 is used as a reference to guide multiple laser beams to intersect on the surface of the sphere, including guiding multiple laser beams to intersect at a cross section where the same center of the circle is located.

[0109] In some embodiments, at least one dose detection module is used to detect a first actual dose of the radiation beam emitted by each beam module; and the difference between the first actual dose and a first theoretical dose of the radiation beam emitted by each beam module is used to characterize the intersection deviation.

[0110] In some embodiments, at least one dose detection module includes at least one dosimeter or at least one ionization chamber.

[0111] In some embodiments, at least one dosimeter includes multiple dosimeters, and multiple radiation detection areas of the multiple dosimeters are distributed in a ring shape to correspond one-to-one to multiple beam emission positions of multiple beam modules; so that the multiple dosimeters detect the first actual dose of each radiation beam in the multiple radiation beams one-to-one.

[0112] In some embodiments, at least one ionization chamber includes multiple ionization chambers, and the multiple ray incident angles of the multiple ionization chambers correspond one-to-one to the multiple beam emission positions of the multiple beam modules, so as to receive the multiple radiation beams one-to-one; so that the multiple ionization chambers detect the second actual dose of each radiation beam in the multiple radiation beams one-to-one.

[0113] For the parts not mentioned in the calibration method part, they can be understood by referring to the various embodiments of the calibration device described above. That is, the calibration method part includes steps for controlling the execution of each structure of any one of the device embodiments described above. In addition, the implementation methods, technical problems solved, functions realized, and technical effects achieved of each step in the calibration method part embodiment are the same or similar to the implementation methods, technical problems solved, functions realized, and technical effects achieved of each corresponding structure in the calibration device part embodiment, and will not be repeated here.

[0114] Those skilled in the art will appreciate that the features described in the various embodiments of the present disclosure may be combined and / or combined in a variety of ways, even if such combinations or combinations are not explicitly described in the present disclosure. In particular, without departing from the spirit and teachings of the present disclosure, the features described in the various embodiments of the present disclosure may be combined and / or combined in a variety of ways. All of these combinations and / or combinations fall within the scope of the present disclosure. The embodiments of the present disclosure are described above. However, these embodiments are for illustrative purposes only and are not intended to limit the scope of the present disclosure. Although the embodiments are described above separately, this does not mean that the measures in the various embodiments cannot be used in combination to advantage. The scope of the present disclosure is defined by the attached claims and their equivalents. Without departing from the scope of the present disclosure, those skilled in the art may make a variety of substitutions and modifications, which should all fall within the scope of the present disclosure.

Claims

1. A calibration device for an ultra-high dose rate radiation device, the ultra-high dose rate radiation device comprising a plurality of beam modules for emitting a plurality of radiation beams, the calibration device comprising: A calibration target assembly, comprising a target portion, wherein the target portion is located in a predetermined radiation area of ​​the ultra-high dose rate radiation device during calibration; The target portion is used as a reference to calibrate the intersection deviation of the multiple radiation beams when they converge in the predetermined radiation area.

2. The calibration device according to claim 1, characterized in that The plurality of beam modules are installed on the rotating drum of the ultra-high dose rate radiation device, The target portion is located in a predetermined radiation area of ​​the ultra-high dose rate radiation device during the calibration process, including: During calibration, the center of the target portion is located at the rotation axis of the rotating drum.

3. The calibration device according to claim 2, characterized in that The calibration device also includes: A plurality of laser components are mounted one by one correspondingly at the respective beam emission positions of the plurality of beam modules; The plurality of laser components are used to emit a plurality of laser beams to the target portion to simulate the intersection position where the plurality of radiation beams converge at the predetermined radiation area.

4. The calibration device according to claim 3, characterized in that The target portion comprises: A sphere, wherein the center of the sphere is located at the rotation axis of the rotating drum during calibration.

5. The calibration device according to claim 4, characterized in that: The sphere is drawn with interwoven longitude and latitude lines, The longitude and latitude are used to characterize the intersection deviation between any two laser beams in the multiple laser beams.

6. The calibration device according to claim 4 or 5, characterized in that The plurality of beam modules are distributed in a ring around the rotating drum. The sphere is used as a reference to guide the multiple laser beams to converge on the surface of the sphere.

7. The calibration device according to claim 6, characterized in that The radius of the sphere is less than or equal to a predetermined threshold, and the center of the sphere coincides with the position of the target point in the predetermined radiation area. The predetermined threshold is used to constrain the error between the impact position of any laser beam and the target radiotherapy position.

8. The calibration device according to claim 5, characterized in that The calibration target assembly further includes a support frame, wherein the support frame includes: A base is mounted on the inner wall of the rotary drum, wherein the curvature of the bottom surface of the base matches the curvature of the mounting area on the inner wall of the rotary drum; A connecting member, a first end of which is connected to the base, and a second end of which is connected to the sphere.

9. The calibration device according to claim 6, characterized in that The distances between the beam emission positions of the plurality of beam modules and the target portion are substantially equal.

10. The calibration device according to claim 1, characterized in that The target portion comprises: at least one dose detection module, used for detecting a first actual dose of the radiation beam emitted by each beam module; The difference between the first actual dose and the first theoretical dose of the radiation beam emitted by each beam module is used to characterize the intersection deviation.

11. The calibration device according to claim 10, characterized in that The at least one dose detection module comprises: At least one dosimeter is used to detect a first actual dose of the radiation beam emitted by each beam module.

12. The calibration device according to claim 11, characterized in that The at least one dosimeter includes a plurality of dosimeters, and the plurality of beam modules are distributed in an annular manner around the rotating drum of the ultra-high dose rate radiation device. The multiple radiation detection areas of the multiple dosimeters are distributed in a ring shape to correspond one-to-one to the multiple beam emission positions of the multiple beam modules; The multiple dosimeters are used to detect the first actual dose of each radiation beam in the multiple radiation beams in a one-to-one correspondence.

13. The calibration device according to claim 10, characterized in that The at least one dose detection module comprises: at least one ionization chamber, used to detect a second actual dose of the radiation beam emitted by each beam module; The difference between the second actual dose and the first theoretical dose of the radiation beam emitted by each beam module is used to characterize the intersection deviation.

14. The calibration device according to claim 13, characterized in that The at least one ionization chamber comprises a plurality of ionization chambers, the plurality of beam modules are distributed in an annular manner around the rotating drum of the ultra-high dose rate radiation device, The multiple ray incident angles of the multiple ionization chambers correspond one-to-one to the multiple beam emission positions of the multiple beam modules, so as to receive the multiple radiation beams one-to-one; The multiple ionization chambers are used to detect the second actual dose of each radiation beam in the multiple radiation beams in a one-to-one correspondence.

15. A calibration method for an ultra-high dose rate radiation device, the ultra-high dose rate radiation device comprising a plurality of beam modules for emitting a plurality of radiation beams, the calibration method comprising: During the calibration process, the target of the calibration target assembly is arranged in a predetermined radiation area of ​​the ultra-high dose rate radiation device; The target portion is used as a reference to calibrate the intersection deviation of the multiple radiation beams when they intersect in the predetermined radiation area.

16. An ultra-high dose rate radiation device, comprising: Rotary drum; A plurality of beam modules for emitting a plurality of radiation beams, wherein the plurality of beam modules are distributed in an annular manner around the rotating drum; Wherein, the multiple beam modules are configured to be calibrated by the calibration equipment described in any one of claims 1 to 14 so as to converge the multiple radiation beams into a predetermined radiation area.

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