Dudleya rabiosa endophyte and application thereof

The preparation of secondary metabolites by fermentation of the endophytic bacterium Aspergillus sp. PS4 of wild strawberry solves the problem of insufficient utilization of active ingredients of wild strawberry endophytic bacteria in the prior art, achieves significant antibacterial and antitumor effects, improves product stability and yield, and provides an environmentally friendly preparation method.

CN119662416BActive Publication Date: 2026-06-19ZHEJIANG UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHEJIANG UNIV OF TECH
Filing Date
2024-10-25
Publication Date
2026-06-19

AI Technical Summary

Technical Problem

Existing technologies are insufficient to effectively utilize the active ingredients of endophytic bacteria in wild strawberries, especially in the preparation of antibacterial agents and antitumor drugs. Furthermore, the fermentation process is not environmentally friendly and makes it difficult to produce stable active ingredients on a large scale.

Method used

Fermentation was carried out using the endophytic bacterium Aspergillus sp. PS4 of Duchesnea indicum to prepare secondary metabolites, including protocatechuic acid, azelaic acid, salicylic acid, methyl gallate, methyl palmitate, shikonin, and 10-hydroxycamptothecin, under specific culture media and conditions. These products are used to prepare antibacterial agents and antitumor drugs.

Benefits of technology

Significant antibacterial and antitumor activities were achieved, improving product stability and yield. The bio-fermentation method is more environmentally friendly, providing new clinical treatment options, especially significant for combating drug-resistant strains and antitumor drugs.

✦ Generated by Eureka AI based on patent content.

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Abstract

This invention discloses an endophytic fungus of *Aspergillus sp.* and its applications. The invention provides a novel endophytic fungus, PS4, which possesses unique antibacterial and antitumor activities. The secondary metabolites produced during fermentation contain various active ingredients, such as shikonin, 10-hydroxycamptothecin, and rhodioloside, exhibiting significant antioxidant, antibacterial, and antitumor effects. Simultaneously, the controllable fermentation process of the endophytic fungus improves the stability and yield of the product. The use of bio-fermentation is more environmentally friendly, reducing environmental impact, and ultimately provides a new option for clinical treatment, especially in combating drug-resistant strains and antitumor drugs.
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