Tibetan veterinary drug formula for treating calf diarrhea and preparation method thereof

Abstract

The invention discloses a Tibetan veterinary drug formula for treating calf diarrhea. The Tibetan veterinary drug formula is prepared from the following raw materials in parts by weight: 7 parts of rhizoma coptidis, 4 parts of flos carthami, 2 parts of herba taxilli, 4 parts of fructus chebulae, 1-1.5 parts of vulture excrement, 0.6-1 part of gypsum rubrum and 0.2-1 part of musk. The weight ratio of the rhizoma coptidis to the flos carthami to the herba taxilli to the fructus chebulae to the vulture excrement to the gypsum rubrum to the musk is 0.4: 1.5: 1: 2: 4: 4: 7.5. The Tibetan veterinary drug is reasonable in structural design, the prepared Tibetan veterinary drug has the effects of clearing heat and stopping diarrhea, treating chronic dysentery, bloody stool, calf white dysentery, stomach cold, food indigestion, stomach mass tumor, gastric acid and the like, can inhibit intestinal mucosa epithelial cell exfoliation, reduce mucosa edema and reduce inflammatory cell infiltration, is not prone to bacterial drug resistance, does not affect animal production performance, and compared with traditional western medicines, the Tibetan veterinary drug has the advantages that the Tibetan veterinary drug has good application prospects. The Tibetan veterinary drug compound is small in side effect, high in safety, lasting in curative effect and not prone to drug resistance, and meanwhile the preparation method is simple, low in cost and easy to apply and popularize.

Description

Technical Field

[0001] The invention relates to the technical field of animal medicine, and in particular to a Tibetan veterinary medicine formula for treating calf diarrhea and a preparation method thereof. Background Art

[0002] Calf diarrhea, also known as calf loose stools, can occur all year round and is a common gastrointestinal disease in calves. The disease often begins 2 to 3 days after birth, which has a great impact on the development, growth, and survival of calves. When raised in large groups, the incidence of calf diarrhea often reaches 90% to 100%, and the mortality rate can reach more than 50%, which poses a great threat to the development of the dairy industry. Calf diarrhea is a common disease in animal husbandry, which seriously affects the growth and development of calves and the benefits of breeding.

[0003] Tibetan medicine for treating calf diarrhea is mainly based on the following principles: (1) Regulating the balance of the three factors: Tibetan medicine believes that the human and animal bodies are composed of three factors: long, triba and bacon. Calf diarrhea may be caused by the imbalance of the three factors. Tibetan medicine regulates the three factors, such as using cold drugs to counteract hot diarrhea caused by excessive triba, or using warm drugs to improve cold diarrhea caused by excessive bacon, so as to restore the balance of the three factors and thus improve the symptoms of diarrhea. (2) Regulating the functions of the internal organs: Tibetan medicine focuses on regulating the functions of the internal organs. For calf diarrhea, it mainly acts on the gastrointestinal tract. For example, some Tibetan medicines can enhance the digestive function of the gastrointestinal tract, promote the normal transportation and absorption of food, reduce stagnation in the gastrointestinal tract, and relieve diarrhea caused by indigestion. At the same time, some Tibetan medicines can also repair the gastrointestinal mucosa, enhance the barrier function of the intestine, and reduce the stimulation and damage of harmful substances to the intestine. (3) Clearing away heat and detoxification or removing cold and dampness: If calf diarrhea is caused by heat toxins invading the gastrointestinal tract, the heat-clearing and detoxification ingredients in Tibetan medicine can remove heat toxins, reduce inflammatory reactions, and relieve symptoms such as diarrhea and fever. If the calf is attacked by cold and dampness, Tibetan medicine can play a role in dispelling cold and dampness, eliminating the cold and dampness and restoring normal gastrointestinal function.

[0004] At present, most drugs for treating calf diarrhea are Western medicines. Although they have certain curative effects, they have great side effects, are prone to drug resistance, and their effects decrease after long-term use. Tibetan veterinary medicine, as a traditional medical treasure of my country, is natural, safe, and effective, and has good application prospects for treating calf diarrhea. Therefore, researching and developing a Tibetan veterinary medicine formula for treating calf diarrhea and its preparation method are of great significance for promoting the development of animal husbandry and improving breeding efficiency. Summary of the invention

[0005] The purpose of the present invention is to solve the problems existing in the prior art, and to propose a Tibetan veterinary medicine formula for treating calf diarrhea and a preparation method thereof. The prepared Tibetan veterinary medicine has the effects of treating heat-clearing and diarrhea-stopping, chronic diarrhea, bloody stool, calf white diarrhea, stomach cold, food indigestion, gastric tumor, gastric acid and the like, can inhibit the shedding of intestinal mucosal epithelial cells, reduce mucosal edema, reduce inflammatory cell infiltration, is not easy to produce bacterial resistance, and does not affect animal production performance. At the same time, the preparation method is simple, low-cost, and easy to promote and apply.

[0006] In order to achieve the above object, the present invention adopts the following technical solutions:

[0007] A Tibetan veterinary medicine formula for treating calf diarrhea, the formula comprising the following raw materials in weight ratio: 7 parts of coptis root, 4 parts of safflower, 2 parts of dregs, 4 parts of terminalia chebula, 1-1.5 parts of vulture dung, 0.6-1 part of calcite, and 0.2-1 part of musk;

[0008] The weight ratio of the raw materials is: Coptis chinensis: Carthamus tinctorius: Zhaxun: Terminalia chebula: Vulture dung: Calcite: Musk = 0.4:1.5:1:2:4:4:7.5.

[0009] A method for preparing a Tibetan veterinary medicine for treating calf diarrhea comprises the following steps:

[0010] S1. Raw material preparation:

[0011] Chicken Claw Coptis: Use clean water to thoroughly wash the collected Coptis, remove the dirt and impurities on the surface, and place the washed Coptis in a well-ventilated place for drying. The drying time is 6-8 hours, avoid direct sunlight, and the drying temperature is 40-60℃. Dry until the Coptis becomes hard;

[0012] Safflower: Safflower inflorescences should be spread out immediately after harvesting, and dried in the shade or in the air;

[0013] Residue taming: Take the original medicinal materials, soak them in water, boil them to dissolve, filter them, take the filtrate, put it in a slow fire or steam reaction pot to concentrate it into paste, and dry it to obtain the paste;

[0014] Terminalia chebula: Take the original medicinal material, remove impurities, wash and dry;

[0015] Vulture dung: Take 2 catties of raw materials, crush them, remove impurities, stir-fry at 70 to 90 degrees for 2 to 5 minutes until light yellow, and dry them in the sun.

[0016] Hanshui stone: Use clean water to wash away the dust and impurities on the surface of the Hanshui stone, break it into 2cm-4cm particles, pour it into an iron pan and heat and stir-fry for 2 to 5 minutes until its color turns slightly yellow, spray a little high-quality barley wine, cover it and let it cool, then soak it in yak milk until it is crispy and soft;

[0017] Musk: Take the original medicinal material, remove the capsule, take out the musk kernel, remove impurities, grind it into powder, and store it in a dry container after processing. Seal it and place it in a cool and dry place to prevent moisture and moth.

[0018] S2. Crushing and mixing:

[0019] Put the processed coptis root, safflower, dregs, terminalia chebula, vulture dung, caltrop and musk into a grinder according to the weight ratio, grind into fine powder, and sieve the fine powder;

[0020] Pour the sieved powder into a clean stainless steel or ceramic container and use a clean stirring tool to fully mix the powders of various medicinal materials to avoid uneven local drug concentration.

[0021] S3. Preparation Storage:

[0022] To make powder: put the mixed powder directly into a plastic or glass container with good sealing performance and store it in a cool, dry and ventilated place;

[0023] To make the medicinal liquid: put the medicinal powder into a pot, add 150ml of highland barley wine and 500ml of warm water, stir well, boil over low heat for 10-15 minutes, then cool, filter and store in a well-sealed plastic or glass container.

[0024] Preferably, in S1, the safflower is spread out thinly and air-dried in the field as soon as it is harvested.

[0025] Preferably, in S1, the coptis root, safflower, dregs of the vine, terminalia chebula, vulture dung, caltrop and musk are soaked, washed and air-dried respectively, and the water content of the medicinal materials is controlled to be 8%-12%.

[0026] Preferably, in S2, during the pulverization, the harder medicinal materials may be first put into the pulverizer and pulverized into coarse powder, and then other medicinal materials may be added and pulverized into fine powder.

[0027] Preferably, in S2, the crushed medicinal powder passes through a 80-100 mesh sieve.

[0028] Preferably, in S2, the stirring tool is a stainless steel spoon or a glass rod.

[0029] Preferably, in S3, information such as the drug name, ingredients, weight, and preparation date are indicated on the container.

[0030] Compared with the prior art, the present invention has the following beneficial effects:

[0031] 1. This Tibetan veterinary medicine formula for treating calf diarrhea has the effects of clearing heat and stopping diarrhea, chronic diarrhea, bloody stools, calf white diarrhea, stomach cold, indigestion, gastric tumors, gastric acid, etc. It inhibits the shedding of intestinal mucosal epithelial cells, reduces mucosal edema, reduces inflammatory cell infiltration, is not easy to produce bacterial resistance, and does not affect animal production performance.

[0032] 2. This Tibetan veterinary medicine formula for treating calf diarrhea has been verified by clinical trials to have significant therapeutic effects on the treatment of calf diarrhea. Compared with traditional Western medicine, this Tibetan veterinary medicine compound has fewer side effects, higher safety, lasting efficacy, and is not prone to drug resistance. At the same time, the preparation method of the preparation is simple, low-cost, and easy to promote and apply. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] Figure 1 The present invention is a schematic flow chart of a method for preparing a Tibetan veterinary medicine for treating calf diarrhea. DETAILED DESCRIPTION

[0034] The technical solutions in the embodiments of the present invention will be described clearly and completely below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments.

[0035] A Tibetan veterinary medicine formula for treating calf diarrhea, the formula comprising the following raw materials in weight ratio: 7 parts of coptis root, 4 parts of safflower, 2 parts of dregs, 4 parts of terminalia chebula, 1-1.5 parts of vulture dung, 0.6-1 part of calcite, and 0.2-1 part of musk;

[0036] The weight ratio of the raw materials is: Coptis chinensis: Carthamus tinctorius: Zhaxun: Terminalia chebula: Vulture dung: Calcite: Musk = 0.4:1.5:1:2:4:4:7.5.

[0037] Among them, Coptis chinensis is bitter and cold in nature, and it enters the heart, spleen, stomach, liver, gallbladder, and large intestine meridians. It contains berberine qua (berberine qua), methyl coptisine and other alkaloids, which have the effects of clearing away heat and dampness, purging fire and detoxifying, and is especially good at clearing damp heat in the middle jiao, and has a good therapeutic effect on diarrhea, abdominal pain and other symptoms caused by damp heat;

[0038] Safflower, also known as safflower, is a traditional Chinese medicinal material with multiple medicinal values. Safflower has the function of promoting blood circulation and unblocking meridians, and can be used to improve various symptoms caused by poor blood circulation in animals. The active ingredients in safflower have anti-inflammatory effects and can be used to treat inflammatory reactions in animals.

[0039] Zhaxun is a Tibetan medicine, mainly used to treat gastritis, blood heat in the stomach, bile heat, gastric bleeding and other symptoms. It is also helpful for the treatment of diarrhea. It has the effect of clearing away heat and detoxifying, and can help remove the heat evil in the body, thereby alleviating the symptoms of diarrhea, especially for diarrhea caused by heat syndrome caused by Triba. Triba in Tibetan medicine refers to a heat evil in the body, which may cause symptoms such as diarrhea and abdominal pain;

[0040] Terminalia chebula is a common Chinese medicinal material with the effect of astringing the intestines and stopping diarrhea. It is suitable for treating chronic diarrhea and dysentery caused by spleen deficiency or spleen and kidney deficiency and coldness. Terminalia chebula contains tannins and other ingredients, which can reduce the lubricity of the mucosal surface, reduce intestinal peristalsis, and help relieve diarrhea symptoms.

[0041] Vulture dung can treat insufficient stomach fire and indigestion;

[0042] Hanshui stone can treat indigestion, stomach bloating and cold diarrhea;

[0043] Musk has the effects of opening the orifices and refreshing the mind, promoting blood circulation and menstruation, reducing swelling and relieving pain.

[0044] Therefore, this Tibetan veterinary medicine formula for treating calf diarrhea has the effects of clearing heat and stopping diarrhea, chronic diarrhea, bloody stools, calf white diarrhea, stomach cold, indigestion, gastric tumors, gastric acid, etc., inhibiting the shedding of intestinal mucosal epithelial cells, reducing mucosal edema, reducing inflammatory cell infiltration, not easily producing bacterial resistance, and not affecting animal production performance.

[0045] A method for preparing a Tibetan veterinary medicine for treating calf diarrhea is prepared from the above formula, comprising the following steps:

[0046] S1. Raw material preparation:

[0047] Chicken Claw Coptis: Use clean water to thoroughly wash the collected Coptis, remove the dirt and impurities on the surface, place the washed Coptis in a well-ventilated place for drying (drying time is 6-8 hours), avoid direct sunlight to prevent the effective ingredients of Coptis from being damaged, the drying temperature is 40-60℃, and dry until the Coptis becomes hard;

[0048] Safflower: Safflower inflorescences should be spread out immediately after harvesting, and dried in the shade or in the air. It is preferred that the Safflower be spread out thinly and air-dried in the field immediately after harvesting.

[0049] Residue taming: Take the original medicinal materials, soak them in water, boil them to dissolve, filter them, take the filtrate, put it in a slow fire or steam reaction pot to concentrate it into paste, and dry it to obtain the paste;

[0050] Terminalia chebula: Take the original medicinal material, remove impurities, wash and dry;

[0051] Vulture dung: Take 2 catties of raw materials, crush them, remove impurities, stir-fry at 70 to 90 degrees for 2 to 5 minutes until light yellow, and dry them in the sun.

[0052] Hanshui stone: Use clean water to wash away the dust and impurities on the surface of the Hanshui stone, break it into 2cm-4cm particles, pour it into an iron pan and heat and stir-fry for 2 to 5 minutes until its color turns slightly yellow, spray a little high-quality barley wine, cover it and let it cool, then soak it in yak milk until it is crispy and soft;

[0053] Musk: Take the original medicinal material, remove the capsule, take out the musk kernel, remove impurities, grind it into powder, and store it in a dry container after processing. Seal it and place it in a cool and dry place to prevent moisture and moth.

[0054] The coptis root, safflower, dregs, terminalia chebula, vulture dung, cold water stone and musk are soaked, washed and dried respectively, and the water content of the medicinal materials is controlled to be 8%-12% to ensure the cleanliness and dryness of the raw materials.

[0055] S2. Crushing and mixing:

[0056] Put the processed chicken claw coptis root, safflower, dregs, terminalia chebula, vulture dung, cold water stone, and musk into a grinder according to the weight ratio, grind into fine powder, and sieve the crushed fine powder. When crushing, put the harder medicinal materials into the grinder and grind them into coarse powder first, and then add other medicinal materials and grind them into fine powder. The crushed powder passes through an 80-100 mesh sieve to ensure that the particle size of the powder is uniform and fine.

[0057] Pour the sifted powder into a clean stainless steel or ceramic container and stir it thoroughly with a clean stirring tool. Use a stainless steel spoon or glass rod to mix the powders of various medicinal materials thoroughly to avoid uneven local drug concentration.

[0058] S3. Preparation Storage:

[0059] Preparation of powder: Put the mixed powder directly into a plastic or glass container with good sealing performance, store it in a cool, dry and ventilated place, and mark the container with the drug name, ingredients, weight, preparation date and other information;

[0060] To make the medicinal liquid: put the medicinal powder into a pot, add 150ml of highland barley wine and 500ml of warm water, stir well, boil over low heat for 10-15 minutes, then cool and filter and store in a well-sealed plastic or glass container, and mark the container with the drug name, ingredients, weight, preparation date and other information.

[0061] When used, the powder or liquid medicine can be directly mixed into the calf's feed or drinking water for feeding, and the liquid medicine can also be directly administered. When used, according to the calf's weight and the severity of the disease, generally each calf is given 5-10 grams each time, 2-3 times a day. If the calf has severe diarrhea, add physiological saline or warm water, dilute at a ratio of 1:5-1:10, stir evenly, and slowly inject into the calf's rectum with an enema. The amount of each enema depends on the size and condition of the calf, generally 50-100 ml, 1-2 times a day, so that the drug directly acts on the intestinal lesions, and the anti-inflammatory and antidiarrheal effects are exerted more quickly, while avoiding vomiting and other discomfort reactions that may be caused by oral administration. It is especially suitable for calves in critical condition.

[0062] The following is a further explanation of the Tibetan veterinary medicine formula for treating calf diarrhea through a specific treatment case:

[0063] Case 1

[0064] Symptoms: A 3-month-old calf had severe diarrhea, watery feces, lethargy, loss of appetite, and slightly elevated body temperature.

[0065] Treatment: Prepare the Tibetan veterinary medicine formula for treating calf diarrhea into powder, mix it into the calf's feed and feed it twice a day. The dosage each time is determined in proportion to the calf's weight.

[0066] Results: After 3 days of medication, the calf's diarrhea frequency was significantly reduced, the feces began to gradually take shape, and the mental state improved. After 2 days of continued medication, the calf basically returned to normal.

[0067] Case 2

[0068] Symptoms: Newborn calves develop diarrhea symptoms soon after birth, with loose and soft feces containing undigested milk curds, and their bodies gradually become thinner.

[0069] Treatment: Prepare the Tibetan veterinary medicine formula for treating calf diarrhea into liquid medicine and feed it to calves every day, 20g each time, once in the morning and once in the evening.

[0070] Results: After taking the medicine for 4 consecutive days, the feces characteristics of the calf were significantly improved, the number of diarrhea times decreased, and the calf began to suckle normally. After 2 days of consolidation treatment, the calf recovered completely.

[0071] Case 3

[0072] Symptoms: The calves have diarrhea, the feces are thin and have a bad smell, accompanied by mild abdominal pain, frequent kicking in the abdomen, and reduced feed intake.

[0073] Treatment: Prepare the Tibetan veterinary medicine for treating calf diarrhea into liquid form and administer it by gavage three times a day.

[0074] Results: After 3-4 days of treatment, the diarrhea symptoms of the calves gradually eased, the feces gradually returned to normal, the abdominal pain symptoms disappeared, and the feed intake gradually returned to normal levels.

[0075] The following is a further explanation of the Tibetan veterinary medicine formula for treating calf diarrhea by comparing it with a treatment case of Western medicine:

[0076] 100 calves with diarrhea were selected and randomly divided into two groups, with 50 calves in each group. The two groups of calves were treated with veterinary medicine prepared by the Tibetan veterinary medicine formula for treating calf diarrhea and western medicine for treating diarrhea, namely, they were divided into a Tibetan medicine group and a western medicine group.

[0077]

[0078] Combined with the above data, it can be seen that compared with traditional Western medicine treatment methods, Tibetan medicine has a higher cure rate than traditional Western medicine treatment methods and has advantages. Although the average cure time is longer than Western medicine treatment time, the treatment effect is higher and the efficacy is long-lasting. It is not easy to relapse, and it has small side effects and adverse reactions. It is highly safe and not easy to develop drug resistance.

[0079] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical scheme and inventive concept of the present invention within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A Tibetan veterinary medicine formula for treating calf diarrhea, characterized in that: The formula comprises the following raw materials in weight ratio: 7 parts of coptis root, 4 parts of safflower, 2 parts of dregs, 4 parts of terminalia chebula, 1-1.5 parts of vulture dung, 0.6-1 parts of calcite, and 0.2-1 parts of musk; The weight ratio of the raw materials is: Coptis chinensis: Carthamus tinctorius: Zhaxun: Terminalia chebula: Vulture dung: Calcite: Musk = 0.4:1.5:1:2:4:4:7.

5.

2. A method for preparing a Tibetan veterinary medicine for treating calf diarrhea according to claim 1, which is prepared by the formula described in claim 1, characterized in that: The following steps are involved: S1. Raw material preparation: Chicken Claw Coptis: Use clean water to thoroughly wash the collected Coptis, remove the dirt and impurities on the surface, and place the washed Coptis in a well-ventilated place for drying. The drying time is 6-8 hours, avoid direct sunlight, and the drying temperature is 40-60℃. Dry until the Coptis becomes hard; Safflower: Safflower inflorescences should be spread out immediately after harvesting, and dried in the shade or in the air; Residue taming: Take the original medicinal materials, soak them in water, boil them to dissolve, filter them, take the filtrate, put it in a slow fire or steam reaction pot to concentrate it into paste, and dry it to obtain the paste; Terminalia chebula: Take the original medicinal material, remove impurities, wash and dry; Vulture dung: Take 2 catties of raw materials, crush them, remove impurities, stir-fry at 70 to 90 degrees for 2 to 5 minutes until light yellow, and dry them in the sun. Hanshui stone: Use clean water to wash away the dust and impurities on the surface of the Hanshui stone, break it into 2cm-4cm particles, pour it into an iron pan and heat and stir-fry for 2 to 5 minutes until its color turns slightly yellow, spray a little high-quality barley wine, cover it and let it cool, then soak it in yak milk until it is crispy and soft; Musk: Take the original medicinal material, remove the capsule, take out the musk kernel, remove impurities, grind it into powder, and store it in a dry container after processing. Seal it and place it in a cool and dry place to prevent moisture and moth. S2. Crushing and mixing: Put the processed coptis root, safflower, dregs, terminalia chebula, vulture dung, caltrop and musk into a grinder according to the weight ratio, grind into fine powder, and sieve the fine powder; Pour the sieved powder into a clean stainless steel or ceramic container and use a clean stirring tool to fully mix the powders of various medicinal materials to avoid uneven local drug concentration. S3. Preparation Storage: To make powder: put the mixed powder directly into a plastic or glass container with good sealing performance and store it in a cool, dry and ventilated place; To make the medicinal liquid: put the medicinal powder into a pot, add 150ml of highland barley wine and 500ml of warm water, stir well, boil over low heat for 10-15 minutes, then cool, filter and store in a well-sealed plastic or glass container.

3. The method for preparing a Tibetan veterinary medicine for treating calf diarrhea according to claim 2, characterized in that: In S1, the safflower is spread out thinly and air-dried in the field as soon as it is harvested.

4. A Tibetan veterinary medicine formula for treating calf diarrhea and its preparation method according to claim 2, characterized in that: In S1, the coptis root, safflower, dregs of the vine, terminalia chebula, vulture dung, caltrop and musk are soaked, washed and air-dried respectively, and the water content of the medicinal materials is controlled to be 8%-12%.

5. The method for preparing a Tibetan veterinary medicine for treating calf diarrhea according to claim 2, characterized in that: In S2, during the pulverization, the medicinal materials with a harder texture may be first put into the pulverizer and pulverized into coarse powder, and then other medicinal materials may be added and pulverized together into fine powder.

6. The method for preparing a Tibetan veterinary medicine for treating calf diarrhea according to claim 2, characterized in that: In S2, the crushed medicinal powder passes through a 80-100 mesh sieve.

7. The method for preparing a Tibetan veterinary medicine for treating calf diarrhea according to claim 2, characterized in that: In S2, a stainless steel spoon or a glass rod is used as a stirring tool.

8. The method for preparing a Tibetan veterinary medicine for treating calf diarrhea according to claim 2, characterized in that: In S3, information such as the drug name, ingredients, weight, and preparation date are indicated on the container.

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