Formula of citron fire-clearing lung-moistening cough-relieving paste as well as preparation and use methods thereof

Abstract

The invention discloses a formula of citron fire-clearing lung-moistening cough-relieving paste as well as a preparation method and a use method thereof, and the formula is prepared from the following components in parts by mass: 450-550 parts of citron, 150-250 parts of pericarpium citri reticulatae, 45-55 parts of honey and 500-750 parts of clear water. The preparation method comprises the following steps: mixing the medicinal materials with clear water, decocting into thick decoction, and cooling into ointment; the traditional Chinese medicine is taken orally. A test result of treating a mouse by using the prepared ointment shows that the prepared ointment can play a synergistic role and enhance the drug effect, has the effects of regulating qi and middle warmer, preventing phlegm from forming and stopping coughing, soothing liver-qi stagnation and calming nerves and sedating mind, and can also have a good treatment effect on cough and expectoration left after fever of a patient in combination with actual clinical proving that the ointment also has a good treatment effect on the cough and expectoration problem left after fever of the patient.

Description

Technical Field

[0001] The invention relates to the technical field, and in particular to a formula of a citron fire-clearing, lung-moistening and cough-relieving ointment and a preparation method and a use method thereof. Background Art

[0002] Citron is native to Asia, especially in the subtropical and warm temperate regions. Its cultivation history in China has been more than 2,000 years. In the Eastern Han Dynasty, Yang Fu's "Yiwuzhi" called it "citron". After the Tang and Song Dynasties, it was mostly called citron, and this book follows it. It likes a hot and humid environment, is afraid of severe frost, and cannot tolerate severe cold. It is best to cultivate it on sandy loam with deep soil, loose and fertile soil, rich in humus, and good drainage. Citron can be propagated asexually by cuttings, grafting and layering, or by sexual propagation through sowing. "Sui Xi Ju Diet" records that citron is often used with expectorant and cough suppressant drugs to treat phlegm, cough, chest tightness, etc., but eating too much will damage the liver qi and cause deficiency heat.

[0003] At present, the research on the development and utilization of citron is not systematic and in-depth enough. The main method of using citron to make medicinal materials is to slice and dry it; the method of using citron to make candied fruit, canned food and squeezed beverages is also simple and extensive; the volatile oil contained in citron is only at the level of extraction method and component analysis, and the research on real development and utilization is rarely involved.

[0004] Therefore, this paper proposes the formula of citron heat-clearing, lung-moistening and cough-relieving ointment and its preparation and use method. Summary of the invention

[0005] The invention aims to provide a formula of a citron heat-clearing, lung-moistening and cough-relieving paste which has the effects of regulating qi and harmonizing the middle, resolving phlegm and relieving cough, soothing the liver and relieving depression, and calming the mind and settling the spirit.

[0006] In order to achieve the above technical effects, the present invention is implemented through the following technical scheme: Citron heat-clearing, lung-moistening and cough-relieving ointment, characterized in that it is made of the following components, in parts by mass: 450 to 550 parts of citron, 150 to 250 parts of tangerine peel, 45 to 55 parts of honey, and 500 to 750 parts of clean water.

[0007] Furthermore, it is made from the following components, by mass: 500 parts of citron, 200 parts of tangerine peel, 50 parts of honey, and 600 parts of water.

[0008] Another object of the present invention is to provide a method for preparing the Citron Qinghuo Runfei Zhike Ointment, which is characterized by comprising the following steps:

[0009] S1. Raw material preparation: clean citron and tangerine peel, dry them, and cut them into small pieces for later use;

[0010] S2, weighing raw materials: take 500 parts of cut citrons, 200 parts of cut tangerine peels, 50 parts of honey and 600 parts of water by mass;

[0011] S3, pour all the weighed citron and tangerine peel into a casserole, add 600 parts of water into the casserole, bring to a boil over high heat, then turn to low heat and simmer for 30 to 45 minutes, stirring constantly during the period to prevent the medicinal materials from adhering to the bottom of the beaker;

[0012] S4. After boiling until the citron and tangerine peel are soft, add 50 parts of honey and stir continuously for 5 to 8 minutes to mix the honey and the liquid medicine evenly, then filter the soup with a strainer into a clean open container to obtain an initial liquid medicine;

[0013] S5. Finally, the initial medicinal liquid is placed in a constant temperature water bath at 40-60°C for concentrated boiling until it becomes a viscous liquid. The medicinal liquid is then placed in a storage bottle, cooled at room temperature to form an ointment, and sealed and stored at room temperature. The citron heat-clearing, lung-moistening and cough-relieving ointment can be obtained.

[0014] Another object of the present invention is to provide a method for using the citron fire-clearing, lung-moistening and cough-relieving ointment, which is characterized in that 100 to 200 ml of hot water is used to brew 10 to 20 g of the ointment, and the ointment is continuously stirred during the brewing process until the ointment is dissolved without obvious residue, and then taken orally after cooling; it can be taken orally 1 to 3 times a day, or used as prescribed by a doctor.

[0015] Furthermore, the temperature of the hot water is 70-80°C.

[0016] The beneficial effects of the present invention are:

[0017] The present invention mixes citron, tangerine peel and honey to prepare an ointment, and uses the prepared ointment to treat mice. The treatment results show that the prepared ointment can play a synergistic role, enhance the efficacy of the medicine, and has the effects of regulating qi and harmonizing the middle, resolving phlegm and relieving cough, soothing the liver and relieving depression, and calming the nerves and stabilizing the mind; at the same time, it has a significant effect on the treatment of cough in humans. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings required for describing the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other accompanying drawings can be obtained based on these accompanying drawings without paying creative work.

[0019] Figure 1 The invention discloses a preparation flow chart of the citron heat-clearing, lung-moistening and cough-relieving ointment. DETAILED DESCRIPTION

[0020] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0021] Example 1

[0022] See also Figure 1 As shown, the preparation process of Citron Qinghuo Runfei Zhike Ointment;

[0023] Step 1: Material preparation

[0024] Medicinal materials: Wash citron and tangerine peel, dry them, cut them into small pieces for later use, and then weigh 500 parts of cut citron, 200 parts of cut tangerine peel, 50 parts of honey, and 600 parts of water by mass;

[0025] Equipment: casserole, water bath, stirring spoon, strainer spoon, etc.

[0026] Step 2: Preparation of medicine

[0027] Pour 500 portions of chopped citron and 200 portions of chopped tangerine peel into a casserole, then add 600 portions of water into the casserole, bring to a boil over high heat, then simmer over low heat for 30 to 45 minutes, stirring constantly during the process to prevent the herbs from adhering to the bottom of the beaker;

[0028] After boiling until the citron and tangerine peel are soft, add 50 parts of honey and stir continuously for 5 to 8 minutes to mix the honey and the liquid medicine evenly. Then filter the soup with a strainer into a clean open container to obtain the initial liquid medicine.

[0029] Finally, the initial medicinal liquid is placed in a constant temperature water bath at 40-60°C for concentrated boiling until it becomes a viscous liquid, and then the medicinal liquid is placed in a storage bottle, cooled at room temperature to form an ointment, and then sealed and stored at room temperature; the citron heat-clearing, lung-moistening and cough-relieving ointment can be obtained.

[0030] The effects of citron, tangerine peel and honey in the citron heat-clearing, lung-moistening and cough-relieving ointment are explained as follows: citron has the effects of regulating qi, relieving fullness, digesting food and resolving phlegm, and is often used to treat symptoms such as chest and flank pain, indigestion, and phlegm retention. Tangerine peel can regulate qi and strengthen the spleen, dry dampness and resolve phlegm, and is often used to treat symptoms such as spleen and stomach qi stagnation, vomiting, hiccups, wet phlegm, and cold phlegm cough. Honey has the effects of moistening the lungs and relieving coughs, moistening the intestines and promoting bowel movements, and detoxification.

[0031] Example 2

[0032] The citron fire-clearing, lung-moistening and cough-relieving ointment was prepared and administered to mice, and the process was as follows:

[0033] 1) Preparation of Citron Qinghuo Runfei Zhike Paste: weigh 200g of citron, grind → boil, filter the residue → concentrate → 50ml, and obtain a 4mg / ml citron Qinghuo Runfei Zhike Paste uncondensed liquid (hereinafter referred to as citron water);

[0034] Dosage and Administration: Each mouse was given 0.2 ml of citron water per 10 g body weight by intragastric administration.

[0035] 2) Animal (mice) grouping and administration: 12 Kunming mice were randomly divided into 4 groups (n=3) after adaptive feeding, namely, normal saline group, 1 mg / ml citron water group, 2 mg / ml citron water group and 4 mg / ml citron water group. The dosage of each Kunming mouse was 0.2 ml citron water per 10 g body weight. The positive control was normal saline group.

[0036] 3) Ammonia-induced cough experiment in mice: Each Kunming mouse was given 0.2 ml of citron water or saline of different concentrations per 10 g body weight by gavage. After 20 minutes, the mouse was placed in a cup with 1 g of cotton balls, and 0.4 ml of ammonia water in the cotton balls. A cough was recorded as a contraction of the mouse's chest and abdominal muscles, opening its mouth at the same time, and twitching of the front of the body, with or without a coughing sound. The time from the beginning of the cup placement to the beginning of the mouse's cough was recorded as the coughing latency, and the coughing frequency within 2 minutes was measured at the same time, and the coughing latency and coughing frequency table of each group of mice were obtained as shown in Table 1.

[0037] Group concentration Incubation period / s Number of coughs per 2 minutes Normal saline group — 22.33+2.52 106.67+3.51 1mg / ml group 1mg / ml <![CDATA[48.33+7.77 ** ]]> <![CDATA[88+8.72 ** ]]> 2mg / ml group 2mg / ml <![CDATA[48.33+5.77 ** ]]> <![CDATA[67+8.19 ** ]]> 4mg / ml group 4mg / ml <![CDATA[45.67+6.35 ** ]]> <![CDATA[74+10.39 ** ]]>

[0038] Table 1 Cough latency and cough frequency of mice in each group (x±s, n=3)

[0039] Note: Compared with the control group, ** P<0.01.

[0040] As can be seen from Table 1, the ointment prepared by the present invention has an obvious therapeutic effect on mice with ammonia-induced cough; the treatment results show that the prepared ointment can play a synergistic role, enhance the efficacy of the medicine, and has the effects of regulating qi and harmonizing the middle, resolving phlegm and relieving cough, soothing the liver and relieving depression, and calming the nerves and stabilizing the mind, and can promote the gram weight recovery of mice.

[0041] Example 3

[0042] This embodiment describes the specific patient's condition after use, as follows:

[0043] Step 1: Diagnose the patient as follows:

[0044] The patient, female, 5 years old, had a fever with body temperature fluctuating between 38.5-39℃, accompanied by cough and sputum. Her parents gave her ibuprofen to reduce the fever, and her body temperature returned to normal. After 4 hours, her body temperature rose, and ibuprofen was used again to reduce the fever. After 2 consecutive days, her body temperature returned to normal and she did not have a fever again. After the fever, she had a persistent cough and sputum.

[0045] Step 2: Treatment and recovery, as follows:

[0046] Medical staff prescribed a treatment of citron medicine, which is a medicine and food of the same origin: 9 portions; 9 doses, 3 doses per day, the liquid is extracted by blistering, and taken orally.

[0047] The patient's relatives went to the pharmacy with the prescription as instructed by the doctor, picked up 9 doses, soaked the medicine in water, and took it orally.

[0048] On the first day after the patient's fever subsided, he reported that his cough and sputum production had eased.

[0049] On the second day after the patient's fever subsided, he reported that his cough and sputum production had been greatly reduced.

[0050] On the third day after the patient's fever subsided, his cough and sputum disappeared and he recovered.

[0051] From the above, we can see that 5-year-old Chen had a fever accompanied by cough and sputum. After using ibuprofen to reduce fever, the symptoms recurred. Two days later, the body temperature returned to normal but there were still symptoms of cough and sputum. Subsequently, medical staff used citron, which is both medicine and food, for treatment. They prescribed 9 portions and 9 doses and asked him to take 3 doses of blister liquid orally every day. The patient's relatives took the medicine according to the doctor's instructions. The cough and sputum were relieved on the first day after the fever subsided, and were greatly reduced on the second day. The symptoms disappeared on the third day and the body recovered. It can be seen that citron has a good therapeutic effect on the cough and sputum problems left over after the patient's fever subsided.

Claims

1. Citron heat-clearing, lung-moistening and cough-relieving ointment, characterized in that: The invention is prepared from the following components by weight: 450-550 parts of citron, 150-250 parts of dried tangerine peel, 45-55 parts of honey and 500-750 parts of clean water.

2. The citron heat-clearing, lung-moistening and cough-relieving ointment according to claim 1, characterized in that: The invention is prepared from the following components by weight: 500 parts of citron, 200 parts of dried orange peel, 50 parts of honey, 600 parts of clean water (purified water), and a casserole.

3. The preparation method of the citron heat-clearing, lung-moistening and cough-relieving ointment according to any one of claims 1 or 2, characterized in that: The following steps are involved: S1. Raw material preparation: clean citron and tangerine peel, dry them, and cut them into small pieces for later use; S2, weighing raw materials: take 500 parts of cut citrons, 200 parts of cut tangerine peels, 50 parts of honey and 600 parts of water by mass; S3, pour all the weighed citron and tangerine peel into a casserole, add 600 parts of water into the casserole, bring to a boil over high heat, then turn to low heat and simmer for 30 to 45 minutes, stirring constantly during the period to prevent the medicinal materials from adhering to the bottom of the beaker; S4. After boiling until the citron and tangerine peel are soft, add 50 parts of honey and stir continuously for 5 to 8 minutes to mix the honey and the liquid medicine evenly, then filter the soup with a strainer into a clean open container to obtain an initial liquid medicine; S5. Finally, the initial medicinal liquid is placed in a constant temperature water bath at 40-60°C for concentrated boiling until it becomes a viscous liquid. The medicinal liquid is then placed in a storage bottle, cooled at room temperature to form an ointment, and sealed and stored at room temperature. The citron heat-clearing, lung-moistening and cough-relieving ointment can be obtained.

4. The method for using the Citron Heat-clearing, Lung-moistening and Cough-relieving Ointment according to any one of claims 1 or 2, characterized in that: Use 100-200 ml of hot water to brew 10-20 g of the ointment, and stir continuously during the brewing process until the ointment is dissolved with no obvious residue. Then take it orally after cooling; take 1-3 times a day, or use as directed by a doctor.

5. The method for using the Citron Heat-clearing, Lung-moistening and Cough-relieving Ointment according to claim 4, characterized in that: The temperature of the hot water is 70-80°C.

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