Traditional Chinese medicine formula for eliminating tumors and relieving pain through in-vitro medicine application

Abstract

The invention relates to the technical field of in-vitro medicine application traditional Chinese medicines, and particularly discloses a traditional Chinese medicine formula for eliminating tumors and relieving pain through in-vitro medicine application, which comprises the following components in parts by weight: 30-50g of semen strychni or extract; 5-20 g of asarum or an extract; 5-50 g of ligusticum wallichii or an extract; 10 to 20 g of borneol or an extract; 5-20 g of pseudo-ginseng or an extract of pseudo-ginseng; 5-20 g of dragon's blood or extract; 5-30 g of frankincense or an extract; 5-30 g of myrrh or an extract; the preparation method comprises the following steps: taking the fresh traditional Chinese medicine raw materials of the corresponding components, respectively washing, chopping and mashing, then mixing and putting into a container, and adding water for soaking; finally, the mixed and soaked raw materials are stirred into paste, and the traditional Chinese medicine for eliminating tumors and relieving pain through in-vitro medicine application is prepared. The traditional Chinese medicine for external application has the beneficial effects that the traditional Chinese medicine for external application prepared according to the formula can be used for external application to effectively eliminate tumors and relieve pain, and can well relieve swelling and discomfort caused by body surface tumors to patients, so that the treatment and use requirements of the patients can be well met.

Description

Technical Field

[0001] The invention relates to the technical field of external medicinal application of traditional Chinese medicine, in particular to a traditional Chinese medicine formula for external medicinal application for eliminating tumors and relieving pain. Background Art

[0002] External application, also known as plastering, is a folk therapy that involves applying medicine to specific parts of the body surface to treat diseases.

[0003] Superficial tumors refer to tumors occurring in superficial parts of the body. Conceptually, in addition to skin tumors, they also include tumors occurring in other superficial tissues.

[0004] At present, the existing technology lacks effective Chinese medicine for eliminating tumors and relieving pain that can be used for external medicinal application. It cannot effectively alleviate the swelling, pain and discomfort caused by superficial tumors to patients, and cannot well meet the patients' treatment needs. Therefore, a Chinese medicine formula for external medicinal application for eliminating tumors and relieving pain is proposed. Summary of the invention

[0005] In order to overcome the defects in the prior art and effectively solve the technical problems in the background technology, the present invention provides the following technical solutions:

[0006] A traditional Chinese medicine formula for in vitro application for eliminating tumors and relieving pain comprises the following components in parts by weight: 30-50 grams of Strychnos nux vomica or an extract; 5-20 grams of Asarum or an extract; 5-50 grams of Ligusticum chuanxiong or an extract; 10-20 grams of Borneol or an extract; 5-20 grams of Notoginseng or an extract; 5-20 grams of Sanguisorba officinalis or an extract; 5-30 grams of frankincense or an extract; 5-30 grams of Myrrha or an extract; and 5-30 grams of Corydalis yanhusuo or an extract.

[0007] As a preferred technical solution of the present invention, it includes the following components in parts by weight: 30 grams of Strychnos nux vomica or its extract; 5 grams of Asarum or its extract; 5 grams of Ligusticum chuanxiong or its extract; 10 grams of Borneol or its extract; 5 grams of Panax notoginseng or its extract; 5 grams of Sanguisorba officinalis or its extract; 5 grams of frankincense or its extract; 5 grams of myrrh or its extract; 5 grams of Corydalis yanhusuo or its extract.

[0008] As a preferred technical solution of the present invention, it includes the following components in parts by weight: 40 grams of Strychnos nux vomica or its extract; 12 grams of Asarum or its extract; 27 grams of Ligusticum chuanxiong or its extract; 15 grams of Borneol or its extract; 13 grams of Panax notoginseng or its extract; 12 grams of Sanguisorba officinalis or its extract; 17 grams of frankincense or its extract; 18 grams of Myrrh or its extract; 18 grams of Corydalis yanhusuo or its extract.

[0009] As a preferred technical solution of the present invention, it includes the following components in parts by weight: 50 grams of Strychnos nux vomica or its extract; 20 grams of Asarum or its extract; 50 grams of Ligusticum chuanxiong or its extract; 20 grams of Borneol or its extract; 20 grams of Panax notoginseng or its extract; 20 grams of Sanguisorba officinalis or its extract; 30 grams of frankincense or its extract; 30 grams of Myrrh or its extract; 30 grams of Corydalis yanhusuo or its extract.

[0010] A method for preparing a Chinese medicine formula for eliminating tumors and relieving pain by external medicine application comprises the following steps:

[0011] S1: Take the above-mentioned fresh Chinese medicinal raw materials by weight, wash and set aside;

[0012] S2: Chop and mash the washed Chinese medicine raw materials in S1 for later use; put the mixed raw materials in a container and add water to soak;

[0013] S3: The mixed and soaked raw materials in S2 are stirred into a paste to obtain the traditional Chinese medicine for external application to eliminate tumors and relieve pain.

[0014] A method for preparing a Chinese medicine formula for in vitro application of medicine to eliminate tumors and relieve pain, comprising taking the Chinese medicine extract liquid or powder material corresponding to the above weight parts, mixing them, adding an auxiliary agent and stirring evenly into a paste, thereby preparing the Chinese medicine for in vitro application of medicine to eliminate tumors and relieve pain.

[0015] Compared with the prior art, the beneficial effect of the present invention is that the Chinese medicine for external application for eliminating tumors and relieving pain is prepared from the Chinese medicine formula, which can be used for external application for effectively eliminating tumors and relieving pain, and can well alleviate the swelling, pain and discomfort caused by surface tumors to patients, thereby well meeting the patients' treatment needs.

[0016] In the present invention:

[0017] 1. The medicinal properties and effects of each component drug are:

[0018] Strychnos nux vomica: cold in nature, bitter in taste, highly toxic, and enters the liver and spleen meridians; Functions and indications: For external use, it can dredge meridians and relieve pain, disperse nodules and reduce swelling, dispel wind and dampness, strengthen tendons and bones, and is used for rheumatism, numbness, paralysis, and injuries from falls; carbuncle, swelling and pain, rheumatoid arthritis, myasthenia gravis, facial nerve paralysis, lumbar disc herniation, sciatica, epilepsy, aplastic anemia, sequelae of polio, rheumatoid arthritis, esophageal cancer, gastric cancer, bone tumors, skin cancer, etc.

[0019] Asarum: spicy in taste, warm in nature; enters the heart, lung and kidney meridians; functions and indications: relieves exterior symptoms and dispels cold, dispels wind and relieves pain, opens the orifices, warms the lungs and transforms fluid; used for wind-cold colds, headaches, toothaches, nasal congestion and runny nose, allergic rhinitis, rhinitis, rheumatic arthralgia, and coughs and wheezing due to phlegm and fluid.

[0020] Ligusticum chuanxiong: spicy in taste, warm in nature; enters the liver, gallbladder, and pericardium meridians. Functions and indications: promotes qi and relieves depression, dispels wind and dampness, promotes blood circulation and relieves pain; treats wind-cold headache and dizziness, flank pain and abdominal pain, cold arthritis and muscle spasms, amenorrhea, dystocia, postpartum blood stasis and pain, carbuncles and ulcers.

[0021] Borneol: It tastes pungent and bitter, is slightly cold in nature, and enters the heart, spleen, and lung meridians. Its functions and indications: It can open all orifices, disperse stagnant fire, remove cataracts and improve eyesight, reduce swelling and relieve pain; it can treat lockjaw caused by stroke, coma caused by fever, epilepsy, phlegm, qi stagnation, deafness, throat paralysis, mouth ulcers, otitis media, carbuncle, hemorrhoids, conjunctivitis and cataracts, and pinworm disease.

[0022] Panax notoginseng: sweet in taste; slightly bitter; warm in nature; enters the liver meridian, stomach meridian, heart meridian, lung meridian, and large intestine meridian; calms the mind, has anti-inflammatory and analgesic effects, clears away heat and detoxifies, soothes the liver and improves eyesight, reduces weight, lowers blood lipids, lowers blood pressure, reduces inflammation, stops bleeding, relieves pain, fights cancer, promotes health and anti-aging, and enhances human immunity; mainly used to treat dizziness, migraine, insomnia, vertigo, tinnitus, hypertension, and acute pharyngitis.

[0023] Xuejie: ​​salty in taste, flat in nature, enters the liver meridian of foot Jueyin, functions and indications: dispersing blood stasis and relieving pain, stopping bleeding and promoting tissue regeneration; treating bruises, internal injuries, blood stasis and pain; external bleeding that does not stop, scrofula, and long-term ecthyma ulcers.

[0024] Frankincense: pungent and bitter in taste, warm in nature; enters the heart, liver, and spleen meridians. Functions and indications: regulating qi and activating blood circulation, relieving pain, and expelling toxins; treats qi and blood stagnation, heart and abdominal pain, carbuncles, swelling and toxins, bruises, dysmenorrhea, and postpartum blood stasis and pain.

[0025] Myrrh: bitter and pungent in taste, neutral in nature, non-toxic, enters the twelve meridians, functions and indications: dispersing blood and removing blood stasis, reducing swelling and relieving pain; treating falls, wounds, pain in the tendons and bones, heart and abdomen, masses, amenorrhea, swelling and pain in carbuncles, hemorrhoids, and eye disorders.

[0026] Yuanhu: bitter and pungent in taste, warm in nature; enters the liver, heart and stomach meridians; good at moving and dispersing, can ascend or descend, has the effects of promoting blood circulation and dispersing blood stasis, promoting qi and relieving pain; mainly treats chest pain, heart pain, pain in the ribs, abdomen, headache, back pain, hernia pain, muscle and bone pain, dysmenorrhea, amenorrhea, postpartum abdominal pain due to blood stasis, and traumatic injuries.

[0027] 2. The medicinal properties and efficacy of the formula are analyzed as follows:

[0028] King medicine:

[0029] Nux vomica: With its strong effects of clearing meridians, relieving pain, dispersing nodules and reducing swelling, it dominates the treatment direction of the entire formula, especially for symptoms such as pain and swelling.

[0030] Minister medicine:

[0031] Panax notoginseng, Xuejie: ​​Assist the main drug to enhance the effects of promoting blood circulation, removing blood stasis, stopping bleeding and relieving pain, help improve blood circulation and promote injury repair.

[0032] Frankincense and myrrh: enhance the formula's effects of reducing swelling, promoting tissue regeneration, promoting blood circulation and relieving pain, and have a good effect on bruises, blood stasis, swelling and pain.

[0033] Adjuvant:

[0034] Chuanxiong: With its effects of promoting blood circulation, promoting qi, dispelling wind and relieving pain, it assists the main and auxiliary drugs to make the efficacy of the drugs more extensive, and at the same time can alleviate the adverse reactions that may be caused by some drugs.

[0035] Yuanhu: promotes blood circulation and qi circulation, relieves pain, assists the main and auxiliary drugs, and enhances the analgesic effect.

[0036] Drug:

[0037] Asarum: With its pungent and dispersing nature, it guides the medicine directly to the site of disease, while also enhancing the cold-dispelling and analgesic effects of the entire formula.

[0038] Borneol: Clears away heat and detoxifies, helps alleviate possible thermal reactions to drugs, and enhances the transdermal absorption of drugs. BRIEF DESCRIPTION OF THE DRAWINGS

[0039] Figure 1 It is the number of mice with significant swelling and analgesia effect of the body surface tumor cells of the present invention. DETAILED DESCRIPTION

[0040] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0041] See also Figure 1 The present invention provides a technical solution: a traditional Chinese medicine formula for in vitro application of medicine to eliminate tumors and relieve pain, comprising the following components in parts by weight: 30-50 grams of Strychnos nux vomica or extract; 5-20 grams of Asarum or extract; 5-50 grams of Ligusticum chuanxiong or extract; 10-20 grams of Borneol or extract; 5-20 grams of Panax notoginseng or extract; 5-20 grams of Sanguisorba officinalis or extract; 5-30 grams of frankincense or extract; 5-30 grams of Myrrh or extract; 5-30 grams of Corydalis yanhusuo or extract.

[0042] Embodiment 1:

[0043] According to the components, take 30 grams of Strychnos nux vomica, 5 grams of Asarum, 5 grams of Chuanxiong, 10 grams of Borneol, 5 grams of Panax notoginseng, 5 grams of Sanguisorba officinalis, 5 grams of frankincense, 5 grams of myrrh, and 5 grams of Corydalis yanhusuo; wash, chop and mash them respectively, then mix them in a container and add water to soak them; finally, stir the mixed and soaked raw materials into a paste to prepare the traditional Chinese medicine for external application to eliminate tumors and relieve pain.

[0044] Embodiment 2:

[0045] According to the components, 30 grams of Strychnos nux vomica extract, 5 grams of Asarum extract, 5 grams of Chuanxiong extract, 10 grams of Borneol extract, 5 grams of Panax notoginseng extract, 5 grams of Sanguisorba officinalis extract, 5 grams of frankincense extract, 5 grams of Myrrh extract, and 5 grams of Corydalis yanhusuo extract are taken; after mixing, auxiliary agents are added to mix evenly into a paste to prepare the traditional Chinese medicine for external application to eliminate tumors and relieve pain.

[0046] Embodiment 3:

[0047] According to the components, take 40 grams of Strychnos nux vomica; 12 grams of Asarum; 27 grams of Chuanxiong; 15 grams of Borneol; 13 grams of Panax notoginseng; 12 grams of Sanguisorba officinalis; 17 grams of frankincense; 18 grams of Myrrh; 18 grams of Corydalis; wash, chop and mash them respectively, then mix them in a container and add water to soak them; finally, stir the mixed and soaked raw materials into a paste to prepare the traditional Chinese medicine for external application to eliminate tumors and relieve pain.

[0048] Embodiment 4:

[0049] According to the components, 40 grams of Strychnos nux vomica extract, 12 grams of Asarum extract, 27 grams of Chuanxiong extract, 15 grams of Borneolum extract, 13 grams of Panax notoginseng extract, 12 grams of Sanguisorba officinalis extract, 17 grams of frankincense extract, 18 grams of Myrrh extract and 18 grams of Corydalis yanhusuo extract are taken; after mixing, auxiliary agents are added and mixed into a paste to prepare the traditional Chinese medicine for external application to eliminate tumors and relieve pain.

[0050] Embodiment 5:

[0051] According to the components, take 50 grams of Strychnos nux vomica; 20 grams of Asarum; 50 grams of Chuanxiong; 20 grams of Borneol; 20 grams of Panax notoginseng; 20 grams of Sanguisorba officinalis; 30 grams of frankincense; 30 grams of myrrh; 30 grams of Corydalis yanhusuo; wash, chop and mash them respectively, then mix them in a container and add water to soak; finally, stir the mixed and soaked raw materials into a paste to prepare the traditional Chinese medicine for external application to eliminate tumors and relieve pain.

[0052] Embodiment 6:

[0053] According to the components, take 50 grams of Strychnos nux vomica extract; 20 grams of Asarum extract; 50 grams of Chuanxiong extract; 20 grams of Borneol extract; 20 grams of Panax notoginseng extract; 20 grams of Sanguisorba officinalis extract; 30 grams of frankincense extract; 30 grams of Myrrh extract; 30 grams of Corydalis yanhusuo extract; after mixing, add auxiliary agents and mix evenly into a paste to prepare the traditional Chinese medicine for in vitro application to eliminate tumors and relieve pain.

[0054] Experimental Example 1:

[0055] 60 healthy SPF-grade BALB / c mice were selected, and the tumor cells on the surface of the 60 mice were cultured for a certain period of time. Then, they were randomly divided into 6 groups, 10 mice in each group, namely Example 1 group, Example 2 group, Example 3 group, Example 4 group, Example 5 group and Example 6 group, and the mice were given in vitro medicated application of the drugs of the corresponding examples at an appropriate dose per kilogram of body weight, once a day, for 14 consecutive days; after the experiment, the number of mice with significant swelling and analgesic effects of surface tumor cells was observed, recorded and analyzed.

[0056] Result analysis: Figure 1 As shown, the number of mice with significant swelling and analgesic effects of surface tumor cells in Examples 1-6 groups was at a relatively high proportion, among which the number of mice with significant swelling and analgesic effects of surface tumor cells in Examples 3 and 4 groups was the largest, followed by Examples 1 and 2 groups and Examples 5 and 6 groups.

[0057] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A Chinese medicine formula for eliminating tumors and relieving pain by external drug application, characterized in that: The invention comprises the following components in parts by weight: 30-50 g of Strychnos nux vomica or its extract; 5-20 g of Asarum or its extract; 5-50 g of Ligusticum chuanxiong or its extract; 10-20 g of Borneolum Syntheticum or its extract; 5-20 g of Panax notoginseng or its extract; 5-20 g of Sanguisorba officinalis or its extract; 5-30 g of frankincense or its extract; 5-30 g of Myrrha or its extract; 5-30 g of Corydalis yanhusuo or its extract.

2. The Chinese medicine formula for eliminating tumors and relieving pain by external drug application according to claim 1, characterized in that: The invention comprises the following components in parts by weight: 30 grams of Strychnos nux vomica or its extract; 5 grams of Asarum or its extract; 5 grams of Ligusticum chuanxiong or its extract; 10 grams of Borneol or its extract; 5 grams of Panax notoginseng or its extract; 5 grams of Sanguisorba officinalis or its extract; 5 grams of frankincense or its extract; 5 grams of Myrrha or its extract; 5 grams of Corydalis yanhusuo or its extract.

3. The Chinese medicine formula for eliminating tumors and relieving pain by external drug application according to claim 1, characterized in that: The invention comprises the following components in parts by weight: 40 grams of Strychnos nux vomica or its extract; 12 grams of Asarum or its extract; 27 grams of Ligusticum chuanxiong or its extract; 15 grams of Borneolum or its extract; 13 grams of Panax notoginseng or its extract; 12 grams of Sanguisorba officinalis or its extract; 17 grams of frankincense or its extract; 18 grams of Myrrha or its extract; and 18 grams of Corydalis yanhusuo or its extract.

4. The Chinese medicine formula for eliminating tumors and relieving pain by external drug application according to claim 1, characterized in that: The invention comprises the following components in parts by weight: 50g of Strychnos nux vomica or its extract; 20g of Asarum or its extract; 50g of Ligusticum chuanxiong or its extract; 20g of Borneolum or its extract; 20g of Panax notoginseng or its extract; 20g of Sanguisorba officinalis or its extract; 30g of frankincense or its extract; 30g of Myrrha or its extract; 30g of Corydalis yanhusuo or its extract.

5. The method for preparing the Chinese medicine formula for eliminating tumors and relieving pain by external medicine application according to any one of claims 1 to 4, characterized in that: The steps include: S1: Take the above-mentioned fresh Chinese medicinal raw materials by weight, wash and set aside; S2: Chop and mash the washed Chinese medicine raw materials in S1 for later use; put the mixed raw materials in a container and add water to soak; S3: The mixed and soaked raw materials in S2 are stirred into a paste to obtain the traditional Chinese medicine for external application to eliminate tumors and relieve pain.

6. The method for preparing the Chinese medicine formula for eliminating tumors and relieving pain by external drug application according to any one of claims 1 to 4, characterized in that: Take the liquid or powder material of the Chinese herbal medicine extract corresponding to the above weight parts, mix them, add the auxiliary agent and mix them into a paste, and then you can prepare the Chinese medicine for external application to eliminate tumors and relieve pain.

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