Traditional Chinese medicine composition for treating damp-heat accumulation type lichen planus as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention relates to the technical field of traditional Chinese medicine, and particularly discloses a traditional Chinese medicine composition for treating damp-heat type lichen planus as well as a preparation method and application thereof, and the traditional Chinese medicine composition is prepared from the following raw materials: rhizoma atractylodis, cortex phellodendri, radix sophorae flavescentis, semen coicis, cortex moutan and radix achyranthis bidentatae. Atractylodes lancea and phellodendron amurense are used as monarch drugs, the atractylodes lancea is used for eliminating dampness, the phellodendron amurense is used for removing heat, and the two drugs are used together to clear flow and stagnation sources, treat both symptoms and root causes, eliminate dampness and heat and remove damp evil. Sophora flavescens is used as a ministerial drug, and can clear heat, eliminate dampness and induce diuresis. The coix seeds are used as adjuvant drugs, are sweet and light, can tonify and benefit, can clear slight cold, can promote diuresis without hurting body resistance, and can tonify spleen without greasy feeling; the moutan bark is bitter and pungent, can clear away slight cold, and is good for removing heat to cool blood and promoting blood circulation to remove blood stasis; the radix achyranthis bidentatae is used for guiding fire downwards and is used as conductant drugs. The whole traditional Chinese medicine has the effects of eliminating dampness and heat, guiding dampness and heat of upper jiao downwards and discharging the dampness and heat from urine, and has a relatively good treatment effect on damp-heat accumulation type lichen planus, and the effective rate can reach 80.0-86.7% after the traditional Chinese medicine is taken for two treatment courses.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and in particular to a traditional Chinese medicine composition for treating endogenous damp-heat type lichen planus, and a preparation method and application thereof. Background Art

[0002] Lichen planus is a chronic inflammatory skin disease that often affects the skin and mucous membranes, and its pathogenesis is not yet fully understood. Immune abnormalities play a key role in the onset of lichen planus, and it is generally believed that an imbalance in T lymphocyte subsets is one of the important pathogenesis. Current data show that oral lesions are the only manifestation of this disease. Oral lesions in patients with lichen planus are prone to occur in the cheeks, tongue, gums and other parts, and are multiple or bilaterally symmetrically distributed, with white or grayish-white lines or reticular patterns slightly higher than the mucosal surface. Patients feel pain in the mouth, sometimes accompanied by a burning sensation. Western medicine treatment of lichen planus aims to eliminate all diseases related to the oral mucosa, alleviate symptoms and reduce the risk of oral cancer. Its treatment methods include both drug therapy and physical therapy, mainly including glucocorticoids, retinoic acid drugs, immunosuppressants, ultraviolet irradiation and laser therapy. At present, the conventional Western medicine treatment of lichen planus mainly includes applying 0.1% triamcinolone acetonide oral ointment to the affected area, with a treatment period of more than half a year, and can only relieve symptoms, but no complete cure has been reported; glucocorticoids are also the first-line drugs for the treatment of lichen planus. The drug has a significant effect in improving symptoms and controlling the progression of the disease, but it cannot completely cure it. In addition, after stopping glucocorticoids or triamcinolone acetonide oral ointment, the disease is prone to relapse. Summary of the invention

[0003] In view of the shortcomings of existing western medicine in treating lichen planus, such as difficulty in curing, long treatment period and easy relapse, the present application provides a Chinese medicine composition for treating lichen planus of damp-heat internal accumulation type, which has a short treatment course, high cure rate, is not easy to relapse and has no toxic side effects. The Chinese medicine composition has the effect of clearing damp-heat, draws damp-heat in the upper part of the body downward, and has a good therapeutic effect on lichen planus of damp-heat internal accumulation type.

[0004] In order to achieve the above-mentioned object of the invention, the embodiment of the present invention adopts the following technical solution: In a first aspect, the present invention provides a traditional Chinese medicine composition for treating lichen planus of endogenous damp-heat type, comprising the following components in parts by mass: 8 to 12 parts of Atractylodes lancea, 8 to 12 parts of Phellodendron chinense, 6 to 10 parts of Sophora flavescens, 10 to 20 parts of Coix seeds, 15 to 25 parts of Paeonia suffruticosa, and 8 to 12 parts of Achyranthes bidentata.

[0005] In the prescription of the Chinese medicine composition, Atractylodes lancea and Phellodendron chinense are the main drugs. Atractylodes lancea is used to dry dampness, and Phellodendron chinense is used to remove heat. Phellodendron chinense has the wonderful effect of following treatment, and Atractylodes lancea has the function of strengthening the spleen. The two drugs are the main drugs, and the strange and correct way. The two drugs are used together to clear the source of the flow and treat both the symptoms and the root causes, so that dampness and heat can be removed and dampness evil can be removed. Sophora flavescens is the ministerial drug, which is bitter and cold and pure yin, clears heat and reduces urination, clears heat, and resolves dampness and heat from the inside, and can also dry dampness and promote urination, and guide dampness, heat and fire poison out of the urine. Coix seed is an adjuvant, which is sweet, light, penetrating, and replenishing. It can clear water without hurting the body, and strengthen the spleen without nourishing greasiness. Paeonia suffruticosa is bitter, purging, and dispersing, and it can clear water without hurting the body, and strengthen the spleen without nourishing greasiness. Paeonia suffruticosa is bitter, pungent and dispersing, and it can clear water without hurting the body. It is good at clearing heat and cooling blood, promoting blood circulation and removing blood stasis; Achyranthes bidentata leads fire downward, and the two are the guiding drugs. The whole prescription clears dampness and heat, and guides the dampness and heat in the upper part of the body downward, and it is discharged from the urine. It has a good clinical therapeutic effect on lichen planus with internal dampness and heat, and it is not easy to relapse after being cured.

[0006] The Chinese medicine composition for treating lichen planus of endogenous damp-heat type provided by the present invention has a total effective rate of 80.0% to 86.7% after taking two courses of treatment.

[0007] Preferably, the traditional Chinese medicine composition for treating lichen planus of endogenous damp-heat type comprises the following components in parts by mass: 10 to 12 parts of Atractylodes lancea, 10 to 12 parts of Phellodendron chinense, 6 to 8 parts of Sophora flavescens, 10 to 15 parts of Coix seeds, 20 to 25 parts of Paeonia suffruticosa, and 10 to 12 parts of Achyranthes bidentata.

[0008] The atractylodes lancea selected in the present invention is bran-fried atractylodes lancea.

[0009] Preferably, the Chinese medicine composition further comprises at least one of Periostracum Cicadae, Hedyotis Diffusa, Duckweed, Rhizoma Anemarrhenae, Morus Albizia Flavescentis, Dictamni, Panax Notoginseng, Platycladus Orientalis Leaves, Bletilla striata or Albizzia Julibrissin Bark.

[0010] If the symptoms of lichen planus are accompanied by cheilitis symptoms such as itching and peeling of the lips, the basic formula of the Chinese medicine composition can be added with cicada slough, oldenlandia diffusa, duckweed, rhizoma anemarrhenae, white mulberry bark or white mulberry bark; When oral ulcers or erosions occur in addition to the symptoms of lichen planus, Radix notoginseng, Platycladus orientalis leaves, Bletilla striata or Albizzia julibrissin bark and other medicinal ingredients may be added to the basic formula of the Chinese medicine composition.

[0011] In a second aspect, the present invention provides a method for preparing the above-mentioned Chinese medicine composition for treating lichen planus of endogenous damp-heat type, the preparation method comprising the following steps: The components are measured according to the prescription to obtain a total mixture of Chinese medicinal materials, which is then soaked in water, heated for extraction, and the extract is concentrated to obtain a Chinese medicinal composition for treating lichen planus of endogenous damp-heat type.

[0012] The preparation method of the traditional Chinese medicine composition for treating endogenous damp-heat type lichen planus provided by the present invention is simple, suitable for large-scale production, and convenient for popularization and use.

[0013] Preferably, in the preparation method, the material-liquid ratio of the total mixture of Chinese medicinal materials and water is 1:8 to 1:12; The soaking time is 30min~60min.

[0014] Preferably, in the preparation method, the heating extraction includes decoction extraction or reflux extraction, and the present invention is described by taking decoction extraction as an example; The number of extractions is 2 to 3 times; The extraction time is 30 min / time ~ 50 min / time.

[0015] In a third aspect, the present invention provides the use of the above-mentioned traditional Chinese medicine composition for treating lichen planus due to internal accumulation of dampness and heat in the preparation of a medicament for treating lichen planus due to internal accumulation of dampness and heat.

[0016] As skin diseases of the same "damp-heat internal accumulation type", urticaria and eczema in the prior art and lichen planus in the present invention are different in lesions, causes and symptoms. Among them, the pathogenesis of lichen planus is not yet fully understood. It is generally believed that it is mostly caused by emotions. The spleen governs thinking, and thinking too much will damage the spleen. "The spleen governs the transportation and transformation of water and dampness", and the disease is caused by unfavorable metabolism of water and dampness, and the affected part only appears in the mouth. Urticaria and eczema are mostly caused by exogenous "dampness evil" and can appear in any part of the body. In addition, the biggest symptoms of urticaria and eczema are itching, while the symptoms of lichen planus are pain and burning sensation. In terms of treatment principles, urticaria and eczema are mostly exogenous diseases, and the treatment principle is mainly to disperse dampness; lichen planus is an internal injury disease, and the treatment principle provided by the present invention is mainly to dry dampness and strengthen the spleen, and lead heat downward. The prescription of the Chinese medicine composition for treating urticaria, eczema and lichen planus also varies with the treatment principle.

[0017] In a fourth aspect, the present invention provides a drug for treating lichen planus of intrinsic damp-heat type, which is prepared from the Chinese medicine composition for treating lichen planus of intrinsic damp-heat type provided in the first aspect.

[0018] Preferably, the drug for treating endogenous damp-heat type lichen planus is an oral preparation.

[0019] Preferably, the dosage form of the oral preparation is selected from any one of granules, decoctions, capsules, syrups or tablets.

[0020] Optionally, when the dosage form of the oral preparation is granules, the obtained Chinese medicine extract is concentrated, and alcohol is precipitated to obtain a thick paste, the thick paste is dried and crushed, and an appropriate amount of maltodextrin is added, and the granules of the Chinese medicine composition are obtained by dry granulation or wet granulation; Optionally, when the dosage form of the oral preparation is a tablet, the granules obtained by the dry granulation or wet granulation are added with magnesium stearate or zinc stearate as a lubricant and tableted to obtain the tablet; Optionally, when the dosage form of the oral preparation is a capsule, the granules obtained by the dry granulation or wet granulation are added with an appropriate amount of a disintegrant and a lubricant, weighed, and encapsulated to obtain the preparation; Optionally, when the oral preparation is in the form of a syrup, the obtained Chinese medicine extract is concentrated, and monosaccharide syrup is added to a sugar content of 50 g / mL to 60 g / mL, and the mixture is filled and steam sterilized.

[0021] The above preferred dosage form can enhance the efficacy to a greater extent. The daily dosage of the Chinese medicine composition is preferably 65g to 120g (based on crude drugs). BRIEF DESCRIPTION OF THE DRAWINGS

[0022] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings required for use in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0023] Figure 1 These are the cheek mucosa pictures of Case 1 before, during and after treatment; Figure 1 a) Before treatment, Figure 1 b) After 7 days of treatment, Figure 1 c) After treatment. DETAILED DESCRIPTION

[0024] In order to make the purpose, technical solution and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0025] Example 1 The present embodiment provides a traditional Chinese medicine composition for treating lichen planus of endogenous damp-heat type, which comprises the following components and dosages: 12g of Atractylodes lancea, 12g of Phellodendron amurense, 8g of Sophora flavescens, 15g of Coix seeds, 20g of Paeonia suffruticosa and 10g of Achyranthes bidentata; wherein the Atractylodes lancea is stir-fried with bran.

[0026] This embodiment also provides a method for preparing the above-mentioned Chinese medicine composition for treating endogenous damp-heat type lichen planus, and the preparation method comprises the following steps: Weigh the above components according to the prescription amount, mix them evenly to obtain a total mixture of 77 g of Chinese medicinal materials, add 770 mL of water to soak for 50 min, heat and decoct for 3 times, each time for 40 min, wherein the amount of water added during the second decoction is 620 mL, and the amount of water added during the third decoction is 460 mL; filter the decoction to obtain a filtrate, combine the filtrates, and concentrate them under reduced pressure to 300 mL.

[0027] Example 2 The present embodiment provides a traditional Chinese medicine composition for treating lichen planus of endogenous damp-heat type, comprising the following components and dosages: 8g of Atractylodes lancea, 8g of Phellodendron amurense, 10g of Sophora flavescens, 10g of Coix seeds, 25g of Paeonia suffruticosa, 12g of Achyranthes bidentata, 3g of Panax notoginseng, 10g of Platycladus orientalis leaves, 8g of Bletilla striata and 15g of Albizzia julibrissin bark; wherein the Atractylodes lancea is stir-fried with bran.

[0028] This embodiment also provides a method for preparing the above-mentioned Chinese medicine composition for treating endogenous damp-heat type lichen planus, and the preparation method comprises the following steps: Weigh the above components according to the prescription amount, mix them evenly to obtain a total mixture of 109 g of Chinese medicinal materials, add 880 mL of water to soak for 60 min, heat and decoct for 3 times, each time for 30 min, wherein the amount of water added for the second and third decoctions is 660 mL; filter the decoction to obtain a filtrate, combine the filtrates, and concentrate them under reduced pressure to 300 mL.

[0029] Example 3 The present embodiment provides a traditional Chinese medicine composition for treating lichen planus of endogenous damp-heat type, which comprises the following components and dosages: 10g of Atractylodes lancea, 10g of Phellodendron amurense, 6g of Sophora flavescens, 20g of Coix seeds, 15g of Paeonia suffruticosa and 8g of Achyranthes bidentata; wherein the Atractylodes lancea is stir-fried with bran.

[0030] This embodiment also provides a method for preparing the above-mentioned Chinese medicine composition for treating lichen planus of endogenous damp-heat type, and the preparation method comprises the following steps: Weigh the above components according to the prescribed amount, mix them evenly to obtain a total mixture of 69 g of Chinese medicinal materials, add 828 mL of water to soak for 30 min, heat and decoct twice, decocting for 50 min each time, with 690 mL of water added during the second decoction; filter the decoction to obtain a filtrate, combine the filtrates, and concentrate them under reduced pressure to 300 mL.

[0031] Comparative Example 1 Comparative Example 1 provides a preparation method for a Chinese medicine composition, which is basically the same as Example 1, except that "12 g of Atractylodes lancea" in the raw materials is replaced by "12 g of Atractylodes macrocephala", and "12 g of Phellodendron chinense" is replaced by "12 g of Gardenia jasminoides", and the other parameters are the same as Example 1.

[0032] Comparative Example 2 Comparative Example 2 provides a preparation method for a Chinese medicine composition, which is basically the same as Example 1, with the only difference being that "12 g of Atractylodes lancea" in the raw materials is replaced by "6 ​​g of Atractylodes lancea", and "12 g of Phellodendron chinense" is replaced by "15 g of Phellodendron chinense", and the other parameters are the same as Example 1.

[0033] Comparative Example 3 Comparative Example 3 provides a preparation method for a Chinese medicine composition, which is basically the same as Example 1, with the only difference being that "Achyranthes bidentata 8g, Paeonia suffruticosa 20g" in the raw materials are replaced with "Achyranthes bidentata 8g, Paeonia lactiflora 20g", and the other parameters are the same as Example 1.

[0034] Effect example In order to investigate the clinical efficacy of the Chinese medicine compositions provided in the above embodiments and comparative examples, this experiment was conducted, and the specific method is as follows.

[0035] 1. 72 patients with lichen planus who visited our hospital from October 2023 to the end of June 2024 were selected. The clinical manifestations of the 72 patients were as follows: the patients complained of obvious pain or burning sensation in the oral cavity, white reticular patterns appeared in the patient's mouth, accompanied by congested red tongue, enlarged tongue, tooth marks, thick white tongue coating, and rapid pulse; they were diagnosed with damp-heat internal accumulation type oral thrush, non-erosive type. The above cases were randomly divided into six groups, namely, Example 1 to 3 groups and Comparative Example 1 to 3 groups. Among them, Example 1 to 3 groups, 15 people / group; Comparative Example 1 to 3 groups, 9 people / group.

[0036] 2. Treatment Method: The patients in Example 1-3 group and Comparative Example 1-3 group took the decoction of the Chinese medicine composition obtained in Example 1-3 and Comparative Example 1-3 orally, once in the morning and evening, 150 mL / time, half an hour after meals. 30 days is one course of treatment, and two courses of treatment are continued.

[0037] 3. Criteria for determining efficacy: Refer to the "Guidelines for the Diagnosis and Treatment of Oral Lichen Planus (Revised Edition)" and other relevant documents.

[0038] Significantly effective: The white reticular lines (Wickham lines) in the oral cavity disappeared, and the oral pain disappeared.

[0039] Effective: The white reticular lines (Wickham lines) in the oral cavity are significantly lighter or reduced, and the oral pain is significantly relieved.

[0040] Ineffective: There was no change in the white reticular lines (Wickham lines) in the oral cavity, and no improvement in oral pain; Total Effectiveness = ×100% Treatment results: The statistical table of clinical results of 72 patients after two courses of treatment is shown in Table 1.

[0041] Table 1

[0042] As can be seen from the data in Table 1, after two courses of treatment of patients with endogenous damp-heat type lichen planus taking the Chinese medicine composition provided in Examples 1-3 of the present invention, the total effective rate was 80.0% to 86.7%. Follow-up investigations found that patients with marked clinical results did not relapse within half a year of discontinuation of medication. In Comparative Examples 1-3, on the basis of Example 1, after the Atractylodes lancea, Phellodendron chinense, Paeonia suffruticosa or Cyathulae chinensis in the prescription were replaced with Atractylodes macrocephala, Gardenia jasminoides, Paeonia lactiflora or Cyathulae chinensis having the same efficacy, the total effective rate of treatment was significantly lower than that of Example 1.

[0043] In the Chinese medicine composition for treating lichen planus of damp-heat internal accumulation type provided by the present invention, Atractylodes lancea and Phellodendron chinense are the main drugs, which can be used together within a specific range to clear the source of the flow and eliminate damp-heat and dampness. Sophora flavescens is the assistant drug, which can clear heat and resolve damp-heat from the inside, and can also dry dampness and promote diuresis, and guide damp-heat and fire poison out of the urine. Coix seeds are the adjuvant, which can promote diuresis without hurting the body, and strengthen the spleen without nourishing greasiness. Paeonia suffruticosa is good at clearing heat and cooling blood, promoting blood circulation and removing blood stasis; Achyranthes bidentata guides fire downward, and the two are the assistant drugs. The whole prescription clears damp-heat and guides the damp-heat in the upper part of the body downward, and has a good clinical treatment effect on lichen planus of damp-heat internal accumulation type.

[0044] In addition, the Chinese medicine composition provided by the present invention includes Atractylodes lancea, Phellodendron chinense, Sophora flavescens, Coix seed, Paeonia suffruticosa and Achyranthes bidentata, and can be used as a drug for treating lichen planus of endogenous damp-heat type; if the patient has cheilitis symptoms such as itching and peeling of the lips, cicada slough, Hedyotis diffusa, duckweed, Anemarrhena asphodeloides, Morus alba bark or Dictamni bark can be added to the basic formula of the Chinese medicine composition; if the patient has oral ulcers, Panax notoginseng, Platycladus orientalis leaves, Bletilla striata or Albizzia julibrissin can be added to the basic formula of the Chinese medicine composition.

[0045] Typical Cases Case 1: Zhang, female, came to the hospital for oral discomfort for one month. Current medical history: The patient had oral discomfort due to emotional fluctuations one month ago. White reticular patterns appeared on the oral mucosa near the gums, and she felt redness, swelling and burning in the mouth. She went to the Department of Oral Medicine and was diagnosed with lichen planus. After conventional treatment with Western medicine, there was no significant improvement, and the condition persisted thereafter. She was then treated in the Department of Integrated Traditional Chinese and Western Medicine of our hospital. The patient's mental state and diet were OK, her stools were sticky, and her urine was yellow. Previous physical examinations showed no family history, and there were no abnormalities in her personal history, life history, and allergy history. Physical examination showed no abnormalities in general physical examination. Pictures of the cheek mucosa of this case before, during, and after treatment are shown below. Figure 1 Among them, the pictures before treatment are as follows Figure 1 As shown in a), the oral mucosa was red and swollen, white reticular patterns were visible on both sides of the oral mucosa, the tongue was enlarged, and the tongue coating was thick and greasy yellow. The pulse was moist. The patient was diagnosed with lichen planus, damp-heat internal accumulation type. After taking the Chinese medicine composition for treating lichen planus of damp-heat internal accumulation type prepared in Example 1 for 7 days, the patient felt that the burning sensation in the mouth was slightly reduced. The cheek mucosa of this case after taking the medicine for 7 days is shown in the picture Figure 1As shown in b), the redness and swelling of the cheek mucosa were reduced and the white reticular lines were improved. After taking the medicine for one month, there was no burning sensation in the mouth. Figure 1 As shown in c), the white reticular pattern disappeared and the oral mucosa was no longer red and swollen. The patient continued to take the medicine for a second course of treatment to consolidate the condition. There was no recurrence six months after stopping the medicine.

[0046] Case 2: Ci Moumou, male, the patient was diagnosed with oral discomfort and oral ulcers for more than two months. Current medical history: Two months ago, the patient had burning pain in the oral lining due to spicy food and emotional fluctuations. He went to the Department of Oral Medicine and was diagnosed with lichen planus. After conventional treatment, there was no significant improvement, and the condition persisted thereafter; one month ago, due to emotional fluctuations and drinking, the above symptoms recurred and worsened, accompanied by oral erosion and itching of the lips. He then went to the Department of Integrated Traditional Chinese and Western Medicine for treatment. Physical examination showed that the patient had white reticular patterns on the right cheek mucosa of the mouth, accompanied by redness and swelling, three scattered white ulcers in the mouth, red, swollen, and peeling lips, enlarged tongue with tooth marks, red tongue, thick and greasy white fur, and moist pulse. Diagnosed as lichen planus, damp-heat internal accumulation type. After coming to the hospital, the patient took the Chinese medicine composition prepared in Example 2 for treating lichen planus of damp-heat type. After taking it for 5 days, the oral ulcer surface was significantly reduced, the itching around the lips was slightly relieved, and the burning sensation in the mouth was slightly improved; after taking it for 1 month, the burning sensation in the mouth disappeared, the oral ulcer was healed, and there was no abnormal sensation around the lips. Continue to take the medicine for the second course of treatment to consolidate it. There was no recurrence six months after stopping the medicine.

[0047] Case 3: Pei Moumou, male, was diagnosed with lichen planus due to recurrent oral ulcers. The patient refused Western medicine treatment, so he was treated in the Department of Integrated Chinese and Western Medicine. Physical examination showed that the patient's oral mucosa was red and swollen, white reticular patterns appeared on the bilateral mucosa in the oral cavity, scattered ulcers were seen on the lips, the tongue was red, the tongue coating was yellow and greasy, and the pulse was stringy and slippery. Diagnosed as lichen planus, damp-heat endogenous type. After coming to the hospital, the Chinese medicine composition prepared in Example 1 for the treatment of damp-heat endogenous lichen planus was taken. After taking it for 7 days, the area of ​​white reticular patterns in the oral cavity was slightly reduced, the burning sensation in the oral cavity was slightly alleviated, and the degree of redness and swelling improved; after taking it for 1 month, the white reticular patterns in the oral cavity disappeared, the oral mucosa had no redness, swelling, or erosion, and the burning sensation in the oral cavity disappeared. Continue to take the medicine for the second course of treatment to consolidate it. There was no recurrence for half a year after stopping the medication.

[0048] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modification, equivalent substitution or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A Chinese medicine composition for treating lichen planus of endogenous damp-heat type, characterized in that: The invention comprises the following components in parts by weight: 8 to 12 parts of atractylodes, 8 to 12 parts of phellodendron, 6 to 10 parts of sophora flavescens, 10 to 20 parts of coix seeds, 15 to 25 parts of peony bark and 8 to 12 parts of achyranthes bidentata.

2. The Chinese medicine composition for treating lichen planus of endogenous damp-heat type according to claim 1, characterized in that: The invention comprises the following components in parts by weight: 10 to 12 parts of atractylodes, 10 to 12 parts of phellodendron, 6 to 8 parts of sophora flavescens, 10 to 15 parts of coix seeds, 20 to 25 parts of peony bark and 10 to 12 parts of achyranthes bidentata.

3. The Chinese medicine composition for treating lichen planus of endogenous damp-heat type according to claim 1 or 2, characterized in that: The Chinese medicine composition also includes at least one of cicada slough, oldenlandia diffusa, duckweed, rhizoma anemarrhenae, mulberry bark, dittany bark, notoginseng, arborvitae leaves, bletilla striata or julibrissin bark.

4. The method for preparing the Chinese medicine composition for treating lichen planus of endogenous damp-heat type according to any one of claims 1 to 3, characterized in that: The preparation method comprises the following steps: The components are measured according to the prescription to obtain a total mixture of Chinese medicinal materials, which is then soaked in water, heated for extraction, and the extract is concentrated to obtain a Chinese medicinal composition for treating lichen planus of endogenous damp-heat type.

5. The method for preparing the Chinese medicine composition for treating endogenous damp-heat type lichen planus according to claim 4, characterized in that: The material-liquid ratio of the total mixture of Chinese medicinal materials and water is 1:8-1:12; and / or The soaking time is 30min~60min.

6. The method for preparing the Chinese medicine composition for treating endogenous damp-heat type lichen planus according to claim 4, characterized in that: The number of extractions is 2 to 3 times; and / or The extraction time is 30 min / time ~ 50 min / time.

7. Use of the Chinese medicine composition for treating lichen planus of internal damp-heat type according to any one of claims 1 to 3 in the preparation of a medicament for treating lichen planus of internal damp-heat type.

8. A drug for treating lichen planus of endogenous damp-heat type, characterized in that: The Chinese medicine composition for treating lichen planus of endogenous damp-heat type is prepared from the Chinese medicine composition according to any one of claims 1 to 3.

9. The drug for treating lichen planus of endogenous damp-heat according to claim 8, characterized in that: The medicine for treating lichen planus of endogenous damp-heat type is an oral preparation.

10. The drug for treating lichen planus of endogenous damp-heat type according to claim 9, characterized in that: The dosage form of the oral preparation is selected from any one of granules, decoctions, capsules, syrups or tablets.

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