Compound preparation for promoting dry milk and delactation of dairy cow as well as preparation method and application of compound preparation

Abstract

The invention belongs to the technical field of traditional Chinese veterinary medicines, and particularly discloses a compound preparation for promoting dry milk and delactation of dairy cows as well as a preparation method and application of the compound preparation. The traditional Chinese medicine composition provided by the invention can reduce the milk yield of dairy cows and promote milk reduction and delactation of the dairy cows on one hand, and can induce diuresis to alleviate edema and jointly relieve breast distending pain of the dairy cows on the other hand; therefore, the dry milk delactation of the dairy cows can be effectively promoted, the milk leakage rate of the dairy cows and the disease risk of mastitis are reduced, and the dry milk sealing agent can replace chemical medicines such as pasture dry milk sealing agents.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese veterinary medicines, and in particular to a compound preparation for promoting the return of dry milk from dairy cows, and a preparation method and application thereof. Background Art

[0002] This section merely provides background information related to the present disclosure and is not necessarily prior art.

[0003] Milk leakage is a process in which milk is accumulated, the breast is swollen, and milk flows out of the teat ducts due to the high production of dairy cows and the relaxation of nipple sphincters. At present, the international recommendation is that the milk volume before drying should be ≤15kg / d, but the actual situation in China is that some high-producing dairy cows that have reached the dry date have no reduction in milk volume (≥25kg / d). When the dry date is reached, forced drying measures are implemented, causing high-producing dairy cows to be weaned suddenly, and a large amount of milk accumulates in the udder, causing breast swollen and pain, and reducing lying time, which seriously affects the welfare of dairy cows. At the same time, milk provides a good nutrition and growth environment for bacteria and other microorganisms, leading to a high incidence of mastitis during the dry period. According to statistics, about 30% of high-producing dairy cows that want to dry milk at the end of lactation will leak milk within a week after the dry period, and the peak of milk leakage is on the second day after drying; the risk of clinical mastitis in cows that leak milk after the dry period is 4 times that of cows that do not leak milk. At present, the conventional treatment and prevention method of the ranch is to inject a shot of dry milk antibiotics through the nipple to prevent bacterial infection when the cow is dried off, and a shot of nipple sealant to physically block external bacteria from entering the udder and milk from leaking out of the udder, thereby preventing mastitis from occurring after the cow is dried off. However, this measure cannot effectively reduce the milk production of cows, promote the return of milk from the cows, and relieve breast pain. Moreover, due to the high pressure in the milk after drying off, it is easy to cause physical drying failure, resulting in milk leakage, and secondary drying. Therefore, the present invention provides a compound preparation that promotes the return of milk from the dry milk of cows, so that the cow can effectively dry milk after a single administration, thereby reducing the milk leakage rate after the cow is dried off and the risk of mastitis during the dry milk period. Summary of the invention

[0004] Purpose of the invention: The technical problem to be solved by the present invention is to provide a compound preparation for promoting the return of milk from dry milk in dairy cows and its preparation method and application in view of the deficiencies in the prior art.

[0005] Invention concept: Chinese medicine has been used to promote weaning, milk recovery and swelling since ancient times. For example, "Danxi Xinfa" records that women "have milk obstruction and swelling, stir-fry 2 taels of malt, grind into fine powder, and take it with clear soup for four doses." "Yi Zong Jinjian" "Postpartum milk surges and does not stop, it is a great deficiency of qi and blood. If you want to wean, stir-fry malt and boil it into soup as tea." Chinese medicine believes that women's milk is produced by Chongren qi and blood, and the spleen and stomach are the source of qi and blood biochemistry, so the production of milk is related to the spleen and stomach transportation function. The mechanism of malt's milk recovery is closely related to the dosage of malt. A small dose of malt is used to digest food and stimulate appetite, so that water and grain can be transported normally and qi and blood biochemistry is active, then milk is produced naturally, which is the mechanism of malt's lactation. However, a large dose of malt consumes qi and disperses blood, "can lack the source of qi and blood biochemistry", which is the mechanism of milk recovery. At the same time, Alisma has the effects of promoting diuresis and reducing swelling, removing dampness and heat. In traditional Chinese medicine, sweat and blood are of the same origin, and blood and urine are of the same origin, so Alisma is used to promote urination, thereby reducing the water source of the source of qi and blood biochemistry. At the same time, "The Medicinal Properties" says that Alisma "promotes diuresis and relieves stranguria, and replenishes the deficiency of yin", so the use of Alisma will not hurt the body. Therefore, roasted malt and Alisma complement each other, jointly reducing the milk production of dairy cows, thereby promoting the return of milk after dry milk. At the same time, Chinese medicine has natural advantages such as low cost, green, safe, and no residue; therefore, traditional Chinese medicine is selected, and dialectical prescriptions are made according to the theory of Chinese veterinary medicine, hoping to promote the return of milk after dry milk in dairy cows through plant drug therapy, prevent the occurrence of mastitis in dairy cows during the dry milk period, and replace the use of chemical drugs in pastures.

[0006] In order to solve the above technical problems, the present invention discloses the following technical solutions:

[0007] In a first aspect, the present invention discloses a composition for promoting the return of dry milk from dairy cows.

[0008] Wherein, the composition consists of malt and oriental radix; in some embodiments, the weight ratio of malt to oriental radix is ​​9-11:2-4, in some embodiments, 10:3; in some embodiments, the malt is roasted malt.

[0009] The pharmacological properties of each Chinese herbal medicine component in the above Chinese herbal medicine composition are as follows: Roasted malt is sweet and mild in nature, and enters the spleen and stomach meridians; it has the effects of strengthening the spleen and appetizing, and reducing milk and swelling. It is mainly used for indigestion, milk stagnation, breast pain, and weaning of women. Alisma orientalis is sweet and cold in nature, and enters the kidney and bladder meridians; it has the effects of promoting water and dampness, clearing damp heat, and replenishing yin deficiency. It is mainly used for edema, damp heat infection, etc.

[0010] The present invention is formulated according to the principle of syndrome differentiation and treatment based on traditional Chinese veterinary medicine, and has been put into clinical practice for many times; in the formula provided by the present invention, malt is used as the main medicine for reducing milk and relieving swelling, and oriental rhizome is used as the auxiliary medicine for promoting diuresis and relieving swelling, and clearing dampness and heat. On the one hand, the prescription can reduce milk and relieving milk, and promote the absorption of existing milk; on the other hand, it can promote diuresis and reduce swelling, reduce the source of milk production from the source, and at the same time clear dampness and heat, destroy the damp and hot environment that is conducive to the growth of bacteria, and prevent the occurrence of mastitis in the dry period of dairy cows; therefore, the prescription can effectively promote the return of dry milk and milk in high-yield dairy cows, reduce the incidence of milk leakage, and effectively prevent the occurrence of mastitis in the dry period.

[0011] In a second aspect, the present invention discloses a preparation for promoting the return of dry milk from dairy cows.

[0012] Wherein, the preparation is made from the composition described in the first aspect above.

[0013] Wherein, the dosage form of the preparation includes but is not limited to oral dosage form.

[0014] The oral dosage forms include, but are not limited to, oral liquid, granules, powders, powders, pills, tablets or capsules.

[0015] The preparation method of the preparation comprises mixing and grinding the components through 80-120 mesh, or grinding the components through 80-120 mesh and mixing; in some embodiments, the 80-120 mesh is 100 mesh.

[0016] The preparation method of the oral drug dosage form is to use the Chinese medicine contained in the above formula as the active ingredient and add commonly used excipients or auxiliary ingredients to prepare the oral dosage form.

[0017] In a third aspect, the present invention discloses the use of the above-mentioned Chinese medicine composition or the preparation in a product for promoting the return of dry milk from dairy cows.

[0018] In a fourth aspect, the present invention discloses a product for promoting the return of milk from dry milk in dairy cows.

[0019] In the third and fourth aspects above,

[0020] The product has any one of the following effects: promoting the return of milk from dry cows and / or preventing or treating dry period mastitis, wherein the treatment includes reducing the incidence of mastitis.

[0021] Wherein, the composition or the preparation is dissolved in water and taken.

[0022] The dosage of the composition or the preparation is 600-700 g of the composition or preparation per cow, preferably 650 g of the composition or preparation per cow.

[0023] Among them, the products include veterinary drugs, feed, feed additives, etc.

[0024] The preparation method of the feed is to prepare the composition or the preparation into a commonly used dosage form (veterinary medicine or feed additive), and then add it into the feed to prepare the feed that promotes the return of milk from dry milk to dairy cows.

[0025] Among them, when the application is to use the traditional Chinese medicine composition in the preparation of feed additives for promoting the return of milk from dry milk to dairy cows and preventing and treating mastitis during the dry period, and feed for promoting the return of milk from dry milk to dairy cows and preventing and treating mastitis during the dry period; the dosage of the traditional Chinese medicine composition is 10-30g / kg of feed based on complete feed.

[0026] Among them, when the application is for prevention, the Chinese medicine composition is directly fed every day, with a dosage of 0.25-0.5g / kg body weight, preferably, the dosage is 0.35g / kg body weight, which can be taken in divided doses or all at once; or the Chinese medicine composition with a mass fraction of 0.3-0.5% is added to the feed; thereby reducing or replacing antibiotics, and long-term use can significantly promote the return of milk from dry milk to dairy cows, reduce milk accumulation and breast pain, and reduce the occurrence of mastitis during the dry period.

[0027] Wherein, when the application is for treatment, the Chinese medicine composition is directly fed every day, with a dosage of 0.8-1.2 g / kg body weight, which can be taken in divided doses or once, and taken continuously for 1-3 days; or the Chinese medicine composition with a mass fraction of 0.5% is added to the feed for 5-7 days. After using the present invention, it can be seen that the milk production of dairy cows is significantly reduced, and the degree of breast swelling is seriously reduced.

[0028] Beneficial effects: Compared with the prior art, the present invention has the following advantages:

[0029] (1) The Chinese medicine composition provided by the present invention has the effects of reducing milk production, promoting milk production and relieving swelling, promoting diuresis and reducing edema; it is green, safe, has no side effects, and treats both the symptoms and the root causes. Compared with conventional dry milk that uses chemical drugs for sterilization and physical blocking, conventional dry milk can lead to the abuse of antibiotics, produce problems such as drug residues and bacterial resistance, and has no effect on reducing milk production and relieving milk production, and only treats the symptoms but not the root cause. The use of the Chinese medicine composition of the present invention is green, safe, and has no residue, and can effectively promote the dry milk production and relieving milk production of dairy cows, reduce milk leakage, and prevent the occurrence of mastitis during the dry period, thereby ensuring the health of dairy cows during the dry period.

[0030] (2) The Chinese medicine composition provided by the present invention has significant therapeutic effects, and its effect on the recovery of milk production is better than that of conventional Western medicine treatment methods. The overall effective rate can be as high as 90% or more, and the use of milk-drying antibiotics and milk-drying sealants can be reduced or replaced.

[0031] (3) The Chinese medicine composition provided by the present invention has significant therapeutic effects, requires a small dosage, requires fewer times of use, and takes a short time to take effect. After one administration of the Chinese medicine composition of the present invention, the incidence of breast pain and milk leakage after dry-off in dairy cows is significantly reduced, greatly reducing the workload of ranch staff.

[0032] (4) The conventional western medicine drying method on farms can only physically block bacterial infection and milk leakage, and use a large amount of antibiotics to preventively kill bacteria, but it has no effect on promoting the return of milk after drying up, the effect is single, and it is easy to cause breast pain and secondary milk leakage. The Chinese medicine composition provided by the present invention can promote the return of milk after drying up, reduce the intra-milk pressure, and solve the problem of milk leakage from the source.

[0033] (5) The Chinese medicine composition provided by the present invention is safe, has significant efficacy, low cost, good benefits, good palatability, and is easy to use. It is used to promote the return of milk in dairy cows during the dry period, reduce breast pain and milk leakage, and effectively prevent the occurrence of mastitis in dairy cows during the dry period.

[0034] (6) The Chinese medicine composition provided by the present invention has good palatability and is easy to use. It can be diluted with water and administered orally, or added to feed, without the need for nipple injection of a sealing agent. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] The present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments, and the above and / or other advantages of the present invention will become more clear.

[0036] Figure 1 This is a picture of the finished Chinese medicine product of Recipe 2 in Example 1.

[0037] Figure 2 This is a diagram showing the effect of reducing milk production in Example 2.

[0038] Figure 3 This is a diagram of breast swelling in Example 3. DETAILED DESCRIPTION

[0039] The present invention can be better understood according to the following examples. However, it is easy for those skilled in the art to understand that the contents described in the examples are only used to illustrate the present invention, and should not and will not limit the present invention described in detail in the claims.

[0040] The experimental methods described in the following examples are conventional methods unless otherwise specified; the reagents and materials described are commercially available unless otherwise specified.

[0041] Example 1: Experiment on reducing lactation in dairy cows by administering a Chinese herbal medicine three times

[0042] 1. Materials and methods

[0043] 1.1 Experimental Animals

[0044] The experimental animals in this study were high-yielding Holstein cows in the late lactation stage and about to dry up. The experiment was conducted on a large-scale ranch. The experimental cows were fed and managed according to the existing feeding methods of the ranch. They were fed a complete mixed diet three times a day and had free access to food and water. The ranch was equipped with independent beds and exercise yards for the cows.

[0045] 1.2. Trial Drugs

[0046] Recipe 1 (650g of roasted malt), Recipe 2 (500g of roasted malt, 150g of Alisma orientalis), Recipe 3 (325g of roasted malt, 325g of roasted radish seeds), Recipe 4 (325g of roasted malt, 325g of raw malt).

[0047] The parties weighed the above medicinal materials according to the weight ratio, screened, cleaned, dried, mixed, and crushed to 100 mesh for later use.

[0048] 1.3 Test methods

[0049] Thirty-one high-yielding dairy cows (weighing about 800 kg and producing about 25 kg / d) at the end of lactation and about a week before drying up were selected and randomly divided into a control group (n=6), a prescription group 1 (n=5), a prescription group 2 (n=5), a prescription group 3 (n=5), and a prescription group 4 (n=5). The prescriptions of prescriptions 1, 2, 3, and 4 were dissolved in 8L of warm water, stirred well, and administered orally, once a day for each cow, for 3 consecutive days. The control group: administered an equal amount of water. The daily milk production of the dairy cows was then counted to observe the milk-lowering effect of the Chinese medicine compound.

[0050] 2. Results - Effect of Chinese medicine on milk production in dairy cows

[0051] The test results are shown in Table 1. Before administration, there was no significant difference in milk production among the groups. However, after administration, the milk production of each group decreased to varying degrees. Among them, the decrease in Recipe 2: roasted malt + Alisma orientalis group was the largest, and compared with the control group, there was a statistical difference in Recipe 2 (P < 0.05). There was no significant difference between Recipe 1, Recipe 3, and Recipe 4 and the control group. The above results show that Recipe 2, roasted malt plus Alisma orientalis, has the best effect on reducing milk production after administration.

[0052] Table 1 Statistics of milk production of dairy cows in different experimental groups

[0053]

[0054] Note: There are statistical differences among the groups marked with different lowercase letters (P<0.05), and there is no statistical difference among the groups marked with the same lowercase letters (P≥0.05).

[0055] Example 2: A trial of using a Chinese herbal medicine compound to reduce lactation in dairy cows

[0056] In Example 1, we observed that 500g of roasted malt plus 150g of Alisma orientalis had the best lactation-lowering effect. However, the dry milk production process of the ranch generally only administers the drug once on the day of dry milk. Therefore, in order to cater to the production process of the ranch, we try to reduce the number of doses and workload. Therefore, this experiment aims to explore the lactation-lowering effect of the Chinese herbal compound after one dose, and at the same time explore the lactation-lowering effect when 0.5 times the dose is given.

[0057] 1. Materials and methods

[0058] 1.1 Experimental Animals

[0059] The experimental animals in this study were high-yielding Holstein cows in the late lactation stage and about to dry up. The experiment was conducted on a large-scale ranch. The experimental cows were fed and managed according to the existing feeding methods of the ranch. They were fed a complete mixed diet three times a day and had free access to food and water. The ranch was equipped with independent beds and exercise yards for the cows.

[0060] 1.2. Trial Drugs

[0061] Recipe 1 (500g roasted malt, 150g Alisma orientalis), Recipe 2 (250g roasted malt, 75g Alisma orientalis), and water.

[0062] The parties weighed the above medicinal materials according to the weight ratio, screened, cleaned, dried, mixed, and crushed to 100 mesh for later use.

[0063] 1.3 Test methods

[0064] Twenty-four high-yielding dairy cows (weighing about 800 kg and producing about 30 kg / d) at the end of lactation and about a week before drying up were selected and randomly divided into a control group (n=8), a prescription 1 group (n=8), and a prescription 2 group (n=8). The prescriptions in the prescription 1 and prescription 2 groups were dissolved in 8L of warm water, stirred well, and administered once. The control group was administered with an equal amount of water. The daily milk production of the dairy cows was then counted to observe the milk-lowering effect of the Chinese medicine compound.

[0065] 2. Results - Effect of Chinese medicine on milk production in dairy cows

[0066] The test results are as follows Figure 2 As shown in the figure, 4 days before the administration, the milk production of each group was maintained at about 30kg, but after the administration, the milk production of the cows in group 1 decreased significantly, with a decrease of about 3kg / d, and it lasted for two days, which could effectively reduce milk production during the peak period of milk leakage; while the milk production of group 2 had a certain upward trend after the administration, and could not effectively reduce milk production during the peak period of milk leakage; there was no significant change in the control group. The above results show that group 1 has a significant milk reduction effect after the administration, and the duration is relatively long.

[0067] Example 3: Observation on the effect of Chinese herbal medicine compound on the degree of udder swelling and milk leakage after drying up of dairy cows

[0068] In Example 2, we observed that Recipe 1 (500 g of roasted malt and 150 g of Alisma orientalis) had an obvious milk-reducing effect even after one oral administration, and the effect lasted for two days, which just covered the peak of milk leakage on the second day after drying up. Therefore, in order to reduce the dosage and workload of ranch staff, this experiment aimed to explore the effect of Recipe 1 on the degree of udder swelling and nipple milk leakage rate of dry cows after one administration of dry cows.

[0069] 1. Materials and methods

[0070] 1.1 Experimental Animals

[0071] The experimental animals in this study were high-yielding Holstein cows in the late lactation stage, which were in the normal dry-off plan of the ranch and had a daily milk production of about 30kg / d when dry. The experimental cows were fed daily according to the existing feeding methods of the ranch, fed a total mixed diet, fed three times a day, and had free access to food and water. The ranch was equipped with independent beds and exercise yards for the cows.

[0072] 1.2. Trial Drugs

[0073] Recipe 1 (500 g of roasted malt, 150 g of oriental rhizome), Recipe 2 (250 g of roasted malt, 75 g of oriental rhizome). Each party weighs the above medicinal materials according to the weight ratio, screens and washes them, dries them, mixes them, and grinds them into 100 meshes for later use.

[0074] Commonly used antibiotics: Ruchang DC (ceftiofur hydrochloride breast injection (dry period).

[0075] Commonly used nipple sealants: Bismuth subnitrate breast injection (dry period).

[0076] 1.3 Test methods

[0077] Thirty-six high-yielding Holstein cows at the end of lactation, in the normal dry-off plan of the ranch, with a milk yield of about 30 kg / d at dry-off, were randomly divided into square group 1 (n=15), square group 2 (n=6), and a positive control group (n=15).

[0078] Group 1: After the last milking, give an injection of Ruchang DC (ceftiofur hydrochloride breast injection), no dry milk sealant, dissolve Formula 1 in 8L warm water, stir well and take it orally once.

[0079] Group 2: After the last milking, give an injection of Ruchang DC (ceftiofur hydrochloride breast injection), no dry milk sealant, dissolve Formula 2 in 8L warm water, stir well and take it orally once.

[0080] Positive drug group: After the last milking, first inject a shot of Ruchang DC (ceftiofur hydrochloride breast injection (dry period)) through the teat hole, and then inject a shot of Fonbismuth (bismuth subnitrate breast injection (dry period)).

[0081] Then the cows in the Chinese medicine group and the positive drug group were transferred to a normal dry pen and fed under the same feeding conditions. The milk leakage of the cows was then observed on the 1st, 2nd, 3rd, 4th, 5th, 6th, 7th, and 14th days after drying off, and photos were taken on the 0th, 1st, 3rd, 5th, 7th, and 14th days of drying off to record the swelling of the cows' udders.

[0082] 2. Results

[0083] (1) Observation on the effect of Chinese herbal compound on the degree of udder swelling after drying off of dairy cows.

[0084] The test results are as follows Figure 3 As shown: Compared with the control group, the formula 1 group of cows can effectively reduce the degree of udder swelling within 14 days after drying off after one gavage when drying off, and the degree of redness and swelling is significantly reduced, while there is no obvious visual difference between the formula 2 and the control group.

[0085] (2) Observation on the effect of Chinese herbal compound on preventing milk leakage after drying up of dairy cows.

[0086] The test results are shown in Table 2: Compared with the positive control group, the teat leakage rate of the experimental group of dairy cows in the two days and 14 days after dry milking was significantly reduced after dry milking, and the total teat non-leakage rate reached 91.67%, which was higher than the total teat non-leakage rate of 83.33% in the positive control group, while the total teat leakage rate of the formula 2 group was higher, and the total teat non-leakage rate was the lowest, at 79.17%, which may be related to the fact that a small dose of roasted malt promoted the lactation of dairy cows. The above results show that formula 1 can effectively reduce the leakage rate of high-yielding dairy cows after dry milking.

[0087] Table 2 Nipple leakage rate 14 days after drying up

[0088]

[0089] Note: n in the table is the number of teats of a cow. A cow has four teats.

[0090] In summary, the Chinese herbal compound (500g of roasted malt and 150g of oriental rhizome) can significantly reduce the milk production of high-yielding dairy cows after one administration. At the same time, after one administration after drying up, the Chinese herbal compound can significantly reduce the swelling of the cow's udder and reduce the rate of nipple leakage, indicating that the Chinese herbal compound can significantly promote the return of milk after drying up and reduce the risk of mastitis during the dry period, solving the problem that the existing products on the market cannot essentially promote the return of milk after drying up in dairy cows, and the existing patents for the return of milk after drying up require frequent administration, which increases the workload and operation difficulty in the pasture production process.

[0091] The Chinese medicine composition provided by the present invention has the effects of reducing milk production and milk recovery, promoting diuresis and reducing swelling. Compared with the conventional nipple injection of milk-drying antibiotics and nipple sealants to dry milk in ranches, the conventional milk-drying method only uses antibiotics for preventive sterilization and uses sealants to physically block bacteria from entering the udder and milk from leaking out of the udder, which cannot reduce the milk production of dairy cows, cannot promote the milk recovery of dairy cows from the source, and alleviate problems such as breast distension and pain. In addition, a large amount of chemical drugs are used, which is easy to cause problems such as drug residues and bacterial resistance. The present invention can reduce the milk production of dairy cows and promote the reduction of milk production and milk recovery in dairy cows on the one hand, and promote diuresis and reduce swelling on the other hand, and jointly relieve the breast distension and pain in dairy cows. Therefore, the present invention can effectively promote the milk recovery of dairy cows, reduce the milk leakage rate of dairy cows and the risk of mastitis, and can replace the use of chemical drugs such as ranch milk-drying sealants.

[0092] The above-mentioned embodiments only express several implementation methods of the present invention, and the description thereof is relatively specific and detailed, but it cannot be understood as limiting the scope of the patent of the present invention. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, which all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the attached claims.

[0093] The above-mentioned embodiments only express several implementation methods of the present invention, and the description thereof is relatively specific and detailed, but it cannot be understood as limiting the scope of the patent of the present invention. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, which all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the attached claims.

Claims

1. A composition for promoting the return of milk from dry milk in dairy cows, characterized in that: It is composed of malt and Alisma orientalis.

2. The composition according to claim 1, characterized in that The weight ratio of the malt to the rhizoma alismatis is 9-11:2-4, preferably 10:

3.

3. The composition according to claim 1 or 2, characterized in that The malt is roasted malt.

4. A preparation for promoting the return of milk from dry milk in dairy cows, characterized in that: Made from the composition according to any one of claims 1 to 3; preferably, the preparation is in the form of an oral dosage form.

5. The preparation according to claim 4, characterized in that The components are mixed and crushed to pass 80-120 mesh, or the components are crushed and mixed to pass 80-120 mesh; preferably, the passing 80-120 mesh is passing 100 mesh.

6. Use of the composition according to any one of claims 1 to 3 or the preparation according to claim 4 or 5 in the preparation of a product for promoting the return of dry milk in dairy cows.

7. A product for promoting the return of milk from dry milk in dairy cows, characterized in that: The product comprises the composition according to any one of claims 1 to 3 or the preparation according to claim 4 or 5.

8. The use according to claim 6 or the product according to claim 7, characterized in that: The product has any of the following effects: Promote the return of milk from dry cows; Prevent or reduce dry period mastitis.

9. The use according to claim 6 or the product according to claim 7, characterized in that: The composition or the preparation is dissolved in water and taken.

10. The use according to claim 6 or the product according to claim 7, characterized in that: The dosage of the composition or the preparation is 600-700 g of the composition or preparation per cow, preferably 650 g of the composition or preparation per cow.

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