Preparation method of novel ginseng exosome nano drug delivery system
Through the ginseng exosome nanodelivery system equipped with kaempferol nanoenzyme, the application gap of ginseng exosomes in drug delivery and the poor effect of the insoluble drug kaempferol in the treatment of acute lung injury is solved, and efficient drug delivery and significant antioxidant and anti-inflammatory effects are achieved.
CN119679958APending Publication Date: 2025-03-25YANTAI UNIV +1
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Patent Information
- Application Number
- CN202411850073.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-16
- Publication Date
- 2025-03-25
AI Technical Summary
Technical Problem
The prior art is difficult to effectively utilize ginseng exosomes as drug carriers, and insoluble drugs such as kaempol are not effective in treating diseases such as acute lung injury.
Method used
By preparing a ginseng exosome nanodelivery system equipped with kaempferol nanoenzyme, ginseng exosomes are used as a carrier to synergistically play a role in kaempferol nanoenzymes to improve the delivery efficiency and therapeutic effect of drugs.
Benefits of technology
The effective combination of ginseng exosomes and kaempferol nanoenzymes has been achieved, the targeting of drugs and carrier efficiency have been improved, the antioxidant and anti-inflammatory effects have been significantly enhanced, and the treatment potential for diseases such as acute lung injury.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention discloses a preparation method of a novel ginseng exosome nano drug delivery system, and mainly relates to the field of functional medical materials. Comprising the following steps: S1, preparing a ginseng exosome crude extract; s2, centrifuging the crude extract and taking supernate; s3, centrifuging the supernate, and taking the precipitate to obtain an exosome resuspension; s4, preparing a purified ginseng exosome; s5, preparing kaempferol nano-enzyme freeze-dried powder; s6, mixing the ginseng exosome solution with the kaempferol nano-enzyme freeze-dried powder to obtain a ginseng exosome kaempferol nano-enzyme mixed solution; and S7, separating the ginseng exosome loaded with the kaempferol nano enzyme to obtain the ginseng exosome nano delivery system. The preparation method has the beneficial effects that the plant active ingredient ginseng exosome is taken as a delivery carrier to carry the water-soluble kaempferol nano-enzyme, and the water-soluble kaempferol nano-enzyme and the ginseng exosome play a synergistic role, so that the effective loading capacity of the exosome on the medicine is improved, the concentration of the medicine is improved, and the preparation method plays a role in various diseases such as wounds and inflammation; the traditional Chinese medicine composition can be better applied to treatment of acute lung injury.
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