Nano-drug for treating glioma as well as preparation method and application of nano-drug
By using functionalized functional group-modified phospholipid nanocarriers to combine blood-brain barrier-targeting polypeptides and oligonucleotides, they form multifunctional nanodrugs, solving the problem of drugs passing through the blood-brain barrier and reversing the immunosuppressive microenvironment in glioma treatment, achieving efficient glioma inhibition effect.
CN119679959APending Publication Date: 2025-03-25TSINGHUA UNIVERSITY
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Patent Information
- Application Number
- CN202311242228.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2023-09-25
- Publication Date
- 2025-03-25
AI Technical Summary
Technical Problem
The treatment of glioma is facing difficulties such as drug difficulty passing through the blood-brain barrier and reversing the complex immunosuppressive microenvironment, resulting in poor treatment results.
Method used
Nanopharmaceutical compositions, including functionalized functional group-modified phospholipids as nanocarriers, and polypeptides and specific antigenic peptides with blood-brain barrier targeting ability are used to form multifunctional nanodrugs to improve the targeting ability and efficacy of the drug.
Benefits of technology
This nanodrug can efficiently cross the blood-brain barrier, silencing SOCS1 mRNA, promote dendritic cell maturation and T cell activation, effectively inhibit the growth of gliomas, and improve the therapeutic effect.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention provides a nano-drug for treating glioma as well as a preparation method and application of the nano-drug, and particularly, the nano-drug comprises a nano-carrier and a carrier drug. The nano-drug can interact with a receptor on a brain endothelial cell, enters a brain tumor microenvironment through an endocytosis way, promotes antigen presenting cell maturation, activates T cell anti-tumor immune response, and effectively inhibits tumor growth.
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