Streptomyces AH1901-2 and application thereof, and preparation method and application of naphthomycin compound
By isolating Streptomyces AH1901-2 from the soil in Tianshan District, Xinjiang and extracting naphthyroid compounds through liquid fermentation culture, the problem of reducing new compounds in the prior art was solved, and the preparation of naphthyroid compounds and their anti-inflammatory activity were realized.
CN119685212AActive Publication Date: 2025-03-25SHANDONG UNIV
Patent Information
- Application Number
- CN202411872722.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-18
- Publication Date
- 2025-03-25
- Estimated Expiration
- 2044-12-18
AI Technical Summary
Technical Problem
The number of new compounds found in the prior art from actinomycetes derived from base soil has been reduced, resulting in the limitation of the preparation and application of naphthycin-like compounds.
Method used
Streptomyces AH1901-2 was isolated from the rhizosphere soil of the Tianshan area of Xinjiang, and naphthyroidin compounds were extracted and isolated by liquid fermentation and culture of this strain.
Benefits of technology
Naphthyroidin compounds were successfully isolated from Streptomyces AH1901-2, which had a significant inhibitory effect on the production of NO in mouse mononuclear macrophages and had potential anti-inflammatory drugs.
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Abstract
The invention relates to the technical field of biological medicines, in particular to streptomyces AH1901-2 and application thereof as well as a preparation method and application of a naphthomycin compound. The streptomyces sp. AH1901-2 is separated from rhizosphere soil of ligularia macrophyllus in Tianshan region (5.8 degrees E and 28.0 degrees N) in Xinjiang, the naphthomycin compound is separated and purified from liquid fermentation liquor of the streptomyces sp. AH1901-2, and follow-up studies show that the naphthomycin compound has an obvious inhibition effect on generation of mouse mononuclear macrophage NO, can be used for preparing anti-inflammatory drugs, and has a broad application prospect. The composition is used for treating inflammation.
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Citation Information
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