Biological reagent reaction device and working method thereof

By designing an automated biological reagent reaction device, the problems of high labor intensity, low efficiency and high error rate caused by manual operation are solved, and the automatic loading and unloading of test tubes and automatic addition of reagents are realized, which improves the efficiency and accuracy of large-scale biological reagent reactions.

CN119689013APending Publication Date: 2025-03-25HANGZHOU FANGLUE BIOTECHNOLOGY CO LTD
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Patent Information

Application Number
CN202510208240.9
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-02-25
Publication Date
2025-03-25

AI Technical Summary

Technical Problem

When conducting large-scale sample testing, manual handling and transfer of sample test tubes, calibration and verification, loading and unloading of test tube covers, and reagent addition reactions are carried out, resulting in high labor intensity, low work efficiency, easy errors, and affecting the reaction results.

Method used

A biological reagent reaction device is designed, including a loading and unloading mechanism and a reaction mechanism. The loading and unloading mechanism realizes automatic loading and unloading of the test tube rack through a motor-driven transmission system. The reaction mechanism realizes automatic loading and unloading of the test tube cover and automatic addition of reagents through the merge and separation of the clamp seat, the pneumatic cylinder drives the piston and clamp movement, and the rotation of the cap cylinder.

Benefits of technology

Through automated loading and unloading and reaction operations, the efficiency of large-batch biological reagent reactions is significantly improved, the error rate of manual operation is reduced, and the accuracy of reaction results is improved.

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Abstract

The invention relates to a biological reagent reaction device and a working method thereof.The biological reagent reaction device comprises feeding and discharging mechanisms and a reaction mechanism, the reaction mechanism is installed between the two feeding and discharging mechanisms, each feeding and discharging mechanism comprises two vertical frames which are vertically arranged, and a lifting table is slidably installed between the two vertical frames; translation frames are arranged on the two sides of the top of the lifting table in parallel, a sliding frame is installed on the translation frames in a sliding mode, a rotating rod is rotationally installed in an installation groove of the sliding frame, and a first pneumatic cylinder is installed on the outer side of the rotating rod. By means of the feeding and discharging mechanism, the test tube racks at different positions on the multi-layer cart can be carried to the reaction mechanism for reagent reaction, after the reaction is finished, the test tube racks can be carried to the multi-layer cart from the reaction mechanism for storage, and automatic feeding and discharging work of test tubes is achieved during reaction detection of a large batch of biological reagents.
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Description

Technical Field

[0001] The present invention relates to the technical field of biological reagent reaction, and in particular to a biological reagent reaction device and a working method thereof. Background Art

[0002] In the field of medical testing, it is often necessary to extract test samples from the human body, such as blood, urine, etc. for testing.

[0003] When testing large quantities of samples, manual handling of sample tubes, calibration and verification, loading and unloading of tube caps, and reagent addition reactions are required, which results in high labor intensity and low work efficiency. At the same time, long working hours can easily lead to errors, which in turn affect the reaction results. Summary of the invention

[0004] The problem solved by the present invention is to provide a biological reagent reaction device and a working method thereof, which solves the technical problem that when testing a large number of samples, manual sample test tube transportation and transfer, calibration and verification, test tube cover loading and unloading, and reagent addition reaction are performed, resulting in high labor intensity and low work efficiency. At the same time, long-term work is very likely to cause errors, thereby affecting the reaction results.

[0005] In order to achieve the above object, the present invention adopts the following technical solutions: A biological reagent reaction device, comprising a loading and unloading mechanism and a reaction mechanism, wherein the reaction mechanism is installed between two loading and unloading mechanisms, the loading and unloading mechanism comprises two vertically arranged upright frames, a lifting platform is slidably installed between the two upright frames, translation frames are arranged in parallel on both sides of the top of the lifting platform, a slide is slidably installed on the translation frame, a rotating rod is rotatably installed in the installation groove of the slide, a first pneumatic cylinder is installed on the outer side of the rotating rod, and a clamping rod is installed at the telescopic end of the first pneumatic cylinder; The reaction mechanism includes a platform, a longitudinal adjustment frame is installed on the platform, a transverse adjustment frame is slidably installed on the longitudinal adjustment frame, a slider is slidably installed in the transverse adjustment frame, a side seat is installed on the slider, two clamping seats are slidably installed in the side seat, and a number of semicircular clamping grooves are evenly spaced on the two clamping seats, a rotating plate is rotatably installed on the top side of the side seat, a mounting frame seat and a support plate are installed on the rotating plate, a screw capping cylinder is rotatably installed on the rotating plate at equal intervals, a number of reagent injection nozzles are evenly spaced on the support plate, and the spacing between adjacent clamping grooves, adjacent screw capping cylinders and adjacent reagent injection nozzles are the same.

[0006] Preferably, a transmission box is installed at the top of the vertical frame, a first threaded rod is installed in the vertical frame, a first synchronous wheel is installed at the top of the first threaded rod in the transmission box, the two first synchronous wheels are connected by a first synchronous belt transmission, a first motor is installed on the top side of the transmission box, and the output end of the first motor is connected to one of the first synchronous wheels.

[0007] Preferably, a second motor is installed at the end of the translation frame, and a second threaded rod is installed at the output end of the second motor located in the translation frame, and the second threaded rod is threadedly connected to the slide.

[0008] Preferably, a third motor is installed on the slide, and an output end of the third motor is connected to the end of the rotating rod.

[0009] Preferably, a fourth motor is installed on the longitudinal adjustment frame, and the output end of the fourth motor is located in the longitudinal adjustment frame and a third threaded rod is installed therein, and the third threaded rod is threadedly connected to the middle part of the horizontally arranged transverse adjustment frame, and a fifth motor is installed at the end of the transverse adjustment frame, and the output end of the fifth motor is located in the transverse adjustment frame and a fourth threaded rod is installed therein, and the fourth threaded rod is threadedly connected to the slider.

[0010] Preferably, a sixth motor is installed on the side wall of the side seat, and an output end of the sixth motor is located in the side seat and a fifth threaded rod with opposite thread directions at both ends is installed, and both ends of the fifth threaded rod are threadedly connected to the clamp seat.

[0011] Preferably, a seventh motor and a second pneumatic cylinder are installed on the bottom side of the side seat, a polygonal rod is slidably installed inside the output end of the seventh motor, and the polygonal rod is connected to the center of the rotating plate, a swivel is installed on the telescopic end of the second pneumatic cylinder, and the swivel is connected to the rotating plate bearing.

[0012] Preferably, a rotating joint rotatably connected to the screw-on cap cylinder is installed on the top of the mounting frame seat, and the rotating joint is connected to the air pipe, two wheel grooves are provided on the outer side of the screw-on cap cylinder, and the wheel grooves of adjacent screw-on cap cylinders are connected by a second synchronous belt, an eighth motor is installed on the mounting frame seat, a second synchronous wheel is installed at the output end of the eighth motor, and the second synchronous wheel is connected to the wheel groove of the adjacent screw-on cap cylinder through a third synchronous belt transmission.

[0013] Preferably, a plurality of air cavities are provided at equal angles in the screw-on capping cylinder, a piston is installed in the air cavity, and the piston is connected to the clamping block.

[0014] A working method of a biological reagent reaction device, the specific operating steps of the working method are as follows: Step 1: Move the multi-layer trolley equipped with the test tube rack to one of the loading and unloading mechanisms, move another empty multi-layer trolley to another loading and unloading mechanism, drive one of the first synchronous wheels to rotate through the operation of the first motor, realize the rotation of the first threaded rod through the transmission of the first synchronous wheel and the first synchronous belt, drive the lifting platform to rise and fall to correspond to each layer of the multi-layer trolley, drive the second threaded rod to rotate through the operation of the second motor, and then drive the threaded connected slide to move to the outer end of the translation frame, at this time, the rotating rod and the clamping rod move to both sides of the test tube rack, and the clamping rod is driven by the first pneumatic cylinder to move to clamp the test tube rack, and then the slide moves to the inner end of the translation frame, release the clamping, and then move the test tube rack to the lifting platform, adjust the height of the lifting platform to be flush with the platform, and the third motor drives the rotating rod and the clamping rod to rotate 180°, and then the slide moves to the outer end of the translation frame, at this time, the test tube rack is clamped again by moving the clamping rod, and then the slide moves to the inner end of the translation frame again, and the test tube rack moves to the platform; Step 2: The third threaded rod is driven to rotate by the fourth motor, thereby driving the threaded horizontal adjustment frame to rise and fall, the fourth threaded rod is driven to rotate by the fifth motor, thereby driving the threaded slider to move horizontally, and the fifth threaded rod is driven to rotate by the sixth motor to realize the merging and separation of the clamping seat, and the clamping seat is moved to both sides of the longitudinal test tube of the test tube rack, and then the two clamping seats are merged to clamp the longitudinal test tube through the clamping groove, at this time, the second pneumatic cylinder drives the rotating ring and the rotating plate to move downward, and the screw capping cylinder of the mounting frame seat is covered on the test tube cap, and the air cavity is driven to move upward. The internal pressure drives the piston and the clamping block to move, and then the test tube cover is clamped and fixed, the eighth motor drives the second synchronous wheel to rotate, and drives one of the capping cylinders to rotate through the third synchronous belt transmission, and realizes the joint rotation of the capping cylinders through the second synchronous belt transmission, and then the test tube cover on the test tube is screwed off, and then the rotating plate moves down, the test tube cover is separated from the test tube, and the rotating plate is driven by the seventh motor to rotate, the support plate and the reagent injection nozzle are rotated onto the test tube, and then the reagent injection nozzle adds reagents into the test tube for reaction, and after the reaction is completed, the test tube cover is installed on the test tube; Step 3: Use another loading and unloading mechanism to move the test tube racks on the platform to an empty multi-layer trolley in sequence, and at the same time use the loading and unloading mechanism to move the test tube racks on different layers of the multi-layer trolley to the platform in sequence for reagent reaction.

[0015] The beneficial effects of the present invention are as follows: the loading and unloading mechanism can not only transport the test tube racks at different positions on the multi-layer trolley to the reaction mechanism for reagent reaction, but also can transport the test tube racks from the reaction mechanism to the multi-layer trolley for storage after the reaction is completed, so that the automatic loading and unloading of test tubes can be realized during large-scale biological reagent reaction detection; The longitudinal test tubes on the test tube rack are clamped and fixed by merging and separating the clamping seats in the reaction mechanism, and the piston and the clamping block are driven to move by applying pressure to the air cavity, thereby clamping and fixing the test tube caps. The joint rotation of the capping cylinder is realized by the operation of the eighth motor, so that the test tube caps on the test tubes can be screwed off. Then the rotating plate moves downward, and the test tube caps are separated from the test tubes. The rotating plate is driven to rotate by the seventh motor, and the support plate and the reagent injection nozzle are rotated onto the test tubes. Then the reagent injection nozzle adds reagents into the test tubes for reaction. After the reaction is completed, the test tube caps can be easily installed on the test tubes, and the reagent addition and loading and unloading of the test tube caps are automatically completed, thereby greatly improving the reaction efficiency of batch biological reagents. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 It is a schematic diagram of the overall structure of the present invention; Figure 2 This is a schematic diagram of the structure of the loading and unloading mechanism of the present invention; Figure 3 It is a partial cross-sectional view of the loading and unloading mechanism of the present invention; Figure 4 It is a schematic diagram of the first structure of the reaction mechanism of the present invention; Figure 5 It is a second structural schematic diagram of the reaction mechanism of the present invention; Figure 6 It is a cross-sectional view of the mounting frame seat of the present invention; Figure 7 It is a cross-sectional view of the screw-on capping cylinder of the present invention.

[0017] Legend: 1. Loading and unloading mechanism; 2. Reaction mechanism; 3. Vertical frame; 4. Lifting platform; 5. Translation frame; 6. Slide; 7. Mounting slot; 8. Rotating rod; 9. First pneumatic cylinder; 10. Clamping rod; 11. First threaded rod; 12. Transmission box; 13. First synchronous wheel; 14. First synchronous belt; 15. First motor; 16. Second motor; 17. Second threaded rod; 18. Third motor; 19. Platform; 20. Longitudinal adjustment frame; 21. Horizontal adjustment frame; 22. Sliding block; 23. Side seat; 24. Clamping seat; 25. Clamping slot; 26. Rotating plate; 2 7. Mounting frame; 28. Screw cap cylinder; 29. ​​Support plate; 30. Reagent injection nozzle; 31. Fourth motor; 32. Third threaded rod; 33. Fifth motor; 34. Fourth threaded rod; 35. Fifth threaded rod; 36. Sixth motor; 37. Seventh motor; 38. Second pneumatic cylinder; 39. Swivel; 40. Rotary joint; 41. Air pipe; 42. Wheel groove; 43. Second synchronous belt; 44. Eighth motor; 45. Second synchronous wheel; 46. Third synchronous belt; 47. Air cavity; 48. Piston; 49. Clamp; 50. Multilateral rod. DETAILED DESCRIPTION

[0018] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0019] Specific examples are given below.

[0020] See also Figure 1 to Figure 7 A biological reagent reaction device comprises a loading and unloading mechanism 1 and a reaction mechanism 2. The reaction mechanism 2 is installed between the two loading and unloading mechanisms 1. The loading and unloading mechanism 1 comprises two vertically arranged vertical frames 3. A lifting platform 4 is slidably installed between the two vertical frames 3. Translation frames 5 are arranged in parallel on both sides of the top of the lifting platform 4. A slide 6 is slidably installed on the translation frame 5. A rotating rod 8 is rotatably installed in the installation groove 7 of the slide 6. A first pneumatic cylinder 9 is installed on the outer side of the rotating rod 8. A clamping rod 10 is installed at the telescopic end of the first pneumatic cylinder 9. The top of the vertical frame 3 is installed A transmission box 12 is installed, a first threaded rod 11 is installed in the vertical frame 3, the top of the first threaded rod 11 is located in the transmission box 12 and a first synchronous wheel 13 is installed, the two first synchronous wheels 13 are connected through a first synchronous belt 14 for transmission, a first motor 15 is installed on the top side of the transmission box 12, the output end of the first motor 15 is connected to one of the first synchronous wheels 13, a second motor 16 is installed at the end of the translation frame 5, the output end of the second motor 16 is located in the translation frame 5 and a second threaded rod 17 is installed, and the second threaded rod 17 is threadedly connected to the slide 6, and a third motor 18 is installed on the slide 6, and the output end of the third motor 18 is connected to the end of the rotating rod 8, and the first motor 15 drives one of the first synchronous wheels 13 to rotate, and the rotation of the first threaded rod 11 is realized through the transmission of the first synchronous wheel 13 and the first synchronous belt 14, so as to drive the lifting platform 4 to rise and fall corresponding to each layer of the multi-layer cart, and the second threaded rod 17 is driven to rotate by the second motor 16, thereby driving the threadedly connected slide 6 to move to the outer end of the translation frame 5, at which time the rotating rod 8 and the clamping rod 10 move Move to both sides of the test tube rack, drive the clamping rod 10 to move and clamp the test tube rack through the first pneumatic cylinder 9, then move the slide 6 to the inner end of the translation frame 5, release the clamping, and now move the test tube rack to the lifting platform 4, adjust the height of the lifting platform 4 to be flush with the platform 19, and the third motor 18 drives the rotating rod 8 and the clamping rod 10 to rotate 180°, and then the slide 6 moves to the outer end of the translation frame 5, and now the clamping rod 10 moves to clamp the test tube rack again, and then the slide 6 moves to the inner end of the translation frame 5 again, and the test tube rack moves to the platform 19; The reaction mechanism 2 includes a platform 19, a longitudinal adjustment frame 20 is installed on the platform 19, a transverse adjustment frame 21 is slidably installed on the longitudinal adjustment frame 20, a slider 22 is slidably installed in the transverse adjustment frame 21, a side seat 23 is installed on the slider 22, two clamping seats 24 are slidably installed in the side seat 23, and a plurality of semicircular clamping grooves 25 are evenly spaced on the two clamping seats 24, a rotating plate 26 is rotatably installed on the top side of the side seat 23, a mounting frame seat 27 and a support plate 29 are installed on the rotating plate 26, a screw capping cylinder 28 is rotatably installed on the rotating plate 26, and a plurality of reagent injection nozzles 30 are evenly spaced on the support plate 29, the spacing between adjacent clamping grooves 25, the spacing between adjacent screw capping cylinders 28 and the spacing between adjacent reagent injection nozzles 30 are the same, and a fourth electric The output end of the fourth motor 31 is located in the longitudinal adjustment frame 20 and is installed with a third threaded rod 32. The third threaded rod 32 is threadedly connected to the middle part of the horizontally arranged transverse adjustment frame 21. A fifth motor 33 is installed at the end of the transverse adjustment frame 21. The output end of the fifth motor 33 is located in the transverse adjustment frame 21 and is installed with a fourth threaded rod 34. The fourth threaded rod 34 is threadedly connected to the slider 22. The third threaded rod 32 is driven to rotate by the fourth motor 31, thereby driving the threaded transverse adjustment frame 21 to rise and fall. The fourth threaded rod 34 is driven to rotate by the fifth motor 33, thereby driving the threaded slider 22 to move horizontally. A sixth motor 36 is installed on the side wall of the side seat 23. The output end of the sixth motor 36 is located in the side seat 23 and is installed with a threaded rod 34 with opposite ends. The fifth threaded rod 35 has two ends threadedly connected with the clamp seat 24. The sixth motor 36 drives the fifth threaded rod 35 to rotate to realize the merging and separation of the clamp seat 24. The clamp seat 24 is moved to both sides of the longitudinal test tube of the test tube rack. Then, the two clamp seats 24 are merged to clamp the longitudinal test tube through the clamping groove 25. The seventh motor 37 and the second pneumatic cylinder 38 are installed on the bottom side of the side seat 23. The output end of the seventh motor 37 is internally slidably installed with a polygonal rod 50, and the polygonal rod 50 is connected to the center of the rotating plate 26. The telescopic end of the second pneumatic cylinder 38 is installed with a swivel 39, and the swivel 39 is connected to the bearing of the rotating plate 26. The lifting of the swivel 39 and the rotating plate 26 is realized by the second pneumatic cylinder 38. At the same time, when the seventh motor 37 drives the rotating plate 26 to rotate, the swivel 39 is on the rotating plate 2 6, a rotary joint 40 rotatably connected to the screw capping cylinder 28 is installed on the top of the mounting frame seat 27, and the rotary joint 40 is connected to the air pipe 41. When the screw capping cylinder 28 rotates, normal gas delivery is guaranteed. Two wheel grooves 42 are arranged on the outer side of the screw capping cylinder 28, and the wheel grooves 42 of adjacent screw capping cylinders 28 are connected by a second synchronous belt 43. An eighth motor 44 is installed on the mounting frame seat 27, and a second synchronous wheel 45 is installed on the output end of the eighth motor 44. The second synchronous wheel 45 is connected to the wheel groove 42 of the adjacent screw capping cylinder 28 through a third synchronous belt 46. A plurality of air cavities 47 are arranged at equal angles in the screw capping cylinder 28, and a piston 48 is installed in the air cavity 47. The piston 48 is connected to the clamping block 49. The piston 48 and the clamping block 49 are driven to move by applying pressure to the air cavity 47.To facilitate clamping and fixing the test tube cover, the eighth motor 44 drives the second synchronous wheel 45 to rotate, and drives one of the capping cylinders 28 to rotate through the third synchronous belt 46, and the capping cylinders 28 are rotated together through the second synchronous belt 43 to rotate the test tube cover, thereby completing the disassembly and assembly of the test tube cover.

[0021] A working method of a biological reagent reaction device, the specific operating steps of the working method are as follows: Step 1: Move the multi-layer cart equipped with the test tube rack to one of the loading and unloading mechanisms 1, and move another empty multi-layer cart to another loading and unloading mechanism 1. The first motor 15 drives one of the first synchronous wheels 13 to rotate. The first threaded rod 11 is rotated through the transmission of the first synchronous wheel 13 and the first synchronous belt 14, driving the lifting platform 4 to rise and fall to correspond to each layer of the multi-layer cart. The second motor 16 drives the second threaded rod 17 to rotate, and then drives the threadedly connected slide 6 to move to the outer end of the translation frame 5. At this time The rotating rod 8 and the clamping rod 10 move to both sides of the test tube rack, and the clamping rod 10 is driven by the first pneumatic cylinder 9 to move to clamp the test tube rack, and then the slide 6 moves to the inner end of the translation frame 5, and the clamping is released. At this time, the test tube rack is moved to the lifting platform 4, and the height of the lifting platform 4 is adjusted to be flush with the platform 19. The third motor 18 drives the rotating rod 8 and the clamping rod 10 to rotate 180°, and then the slide 6 moves to the outer end of the translation frame 5. At this time, the clamping rod 10 is moved to clamp the test tube rack again, and then the slide 6 moves to the inner end of the translation frame 5 again, and the test tube rack moves to the platform 19; Step 2: The third threaded rod 32 is driven to rotate by the fourth motor 31, thereby driving the threaded lateral adjustment frame 21 to rise and fall, the fourth threaded rod 34 is driven to rotate by the fifth motor 33, thereby driving the threaded slider 22 to move horizontally, and the fifth threaded rod 35 is driven to rotate by the sixth motor 36 to realize the merging and separation of the clamping seat 24, and the clamping seat 24 is moved to both sides of the longitudinal test tube of the test tube rack, and then the two clamping seats 24 are merged to clamp the longitudinal test tube through the clamping groove 25, at this time, the second pneumatic cylinder 38 drives the rotating ring 39 and the rotating plate 26 to move downward, and the screw capping cylinder 28 of the mounting frame seat 27 is covered on the test tube cover, and then ... screw capping cylinder 28 of the screw capping cylinder 28 is moved upward. The pressure in the air cavity 47 drives the piston 48 and the clamping block 49 to move, and then the test tube cover is clamped and fixed, the eighth motor 44 drives the second synchronous wheel 45 to rotate, and drives one of the screw capping cylinders 28 to rotate through the third synchronous belt 46, and realizes the joint rotation of the screw capping cylinders 28 through the second synchronous belt 43, and then the test tube cover on the test tube is screwed off, and then the rotating plate 26 moves down, and the test tube cover is separated from the test tube, and the rotating plate 26 is driven by the seventh motor 37 to rotate, and the support plate 29 and the reagent injection nozzle 30 are rotated onto the test tube, and then the reagent injection nozzle 30 adds reagents into the test tube for reaction, and after the reaction is completed, the test tube cover is installed on the test tube; Step 3: The test tube racks on the platform 19 are transported to an empty multi-layer trolley in sequence by another loading and unloading mechanism 1, and at the same time, the test tube racks on different layers of the multi-layer trolley are moved to the platform 19 in sequence by the loading and unloading mechanism 1 for reagent reaction.

[0022] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical scheme and inventive concept of the present invention within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A biological reagent reaction device, characterized in that: It comprises a loading and unloading mechanism (1) and a reaction mechanism (2), wherein the reaction mechanism (2) is installed between the two loading and unloading mechanisms (1), the loading and unloading mechanism (1) comprises two vertically arranged upright frames (3), a lifting platform (4) is slidably installed between the two upright frames (3), translation frames (5) are arranged in parallel on both sides of the top of the lifting platform (4), a slide (6) is slidably installed on the translation frame (5), a rotating rod (8) is rotatably installed in the installation groove (7) of the slide (6), a first pneumatic cylinder (9) is installed on the outer side of the rotating rod (8), and a clamping rod (10) is installed at the telescopic end of the first pneumatic cylinder (9); The reaction mechanism (2) comprises a platform (19), a longitudinal adjustment frame (20) is mounted on the platform (19), a transverse adjustment frame (21) is slidably mounted on the longitudinal adjustment frame (20), a slider (22) is slidably mounted in the transverse adjustment frame (21), a side seat (23) is mounted on the slider (22), two clamping seats (24) are slidably mounted in the side seat (23), and a plurality of semicircular clamping grooves (25) are evenly spaced on the two clamping seats (24), a rotating plate (26) is rotatably mounted on the top side of the side seat (23), a mounting frame seat (27) and a support plate (29) are mounted on the rotating plate (26), a screw capping cylinder (28) is rotatably mounted on the rotating plate (26) at an equal interval, and a plurality of reagent injection nozzles (30) are evenly spaced on the support plate (29), and the spacing between adjacent clamping grooves (25), the spacing between adjacent screw capping cylinders (28) and the spacing between adjacent reagent injection nozzles (30) are the same.

2. A biological reagent reaction device according to claim 1, characterized in that: A transmission box (12) is installed at the top of the vertical frame (3), a first threaded rod (11) is installed in the vertical frame (3), a first synchronous wheel (13) is installed at the top of the first threaded rod (11) located in the transmission box (12), two first synchronous wheels (13) are connected by a first synchronous belt (14), a first motor (15) is installed on the top side of the transmission box (12), and an output end of the first motor (15) is connected to one of the first synchronous wheels (13).

3. A biological reagent reaction device according to claim 2, characterized in that: A second motor (16) is installed at the end of the translation frame (5); a second threaded rod (17) is installed at the output end of the second motor (16) located inside the translation frame (5); and the second threaded rod (17) is threadedly connected to the slide frame (6).

4. A biological reagent reaction device according to claim 3, characterized in that: A third motor (18) is mounted on the slide (6), and an output end of the third motor (18) is connected to an end of the rotating rod (8).

5. A biological reagent reaction device according to claim 4, characterized in that: A fourth motor (31) is mounted on the longitudinal adjustment frame (20); an output end of the fourth motor (31) is located in the longitudinal adjustment frame (20) and a third threaded rod (32) is mounted therein; the third threaded rod (32) is threadedly connected to a middle portion of a horizontally arranged transverse adjustment frame (21); a fifth motor (33) is mounted at an end of the transverse adjustment frame (21); an output end of the fifth motor (33) is located in the transverse adjustment frame (21) and a fourth threaded rod (34) is mounted therein; the fourth threaded rod (34) is threadedly connected to the slider (22).

6. A biological reagent reaction device according to claim 5, characterized in that: A sixth motor (36) is mounted on the side wall of the side seat (23); an output end of the sixth motor (36) is located inside the side seat (23); a fifth threaded rod (35) having two ends with threads in opposite directions is mounted thereon; and two ends of the fifth threaded rod (35) are threadedly connected to the clamp seat (24).

7. A biological reagent reaction device according to claim 6, characterized in that: A seventh motor (37) and a second pneumatic cylinder (38) are mounted on the bottom side of the side seat (23); a polygonal rod (50) is slidably mounted inside the output end of the seventh motor (37), and the polygonal rod (50) is connected to the center of the rotating plate (26); a swivel (39) is mounted on the telescopic end of the second pneumatic cylinder (38), and the swivel (39) is connected to a bearing of the rotating plate (26).

8. A biological reagent reaction device according to claim 7, characterized in that: A rotary joint (40) rotatably connected to the capping cylinder (28) is mounted on the top of the mounting frame (27), and the rotary joint (40) is connected to the air pipe (41). Two wheel grooves (42) are arranged on the outer side of the capping cylinder (28), and the wheel grooves (42) of adjacent capping cylinders (28) are connected via a second synchronous belt (43). An eighth motor (44) is mounted on the mounting frame (27), and a second synchronous wheel (45) is mounted on the output end of the eighth motor (44), and the second synchronous wheel (45) is transmission-connected to the wheel grooves (42) of adjacent capping cylinders (28) via a third synchronous belt (46).

9. A biological reagent reaction device according to claim 8, characterized in that: A plurality of air cavities (47) are provided at equal angles in the screw-capping cylinder (28), a piston (48) is installed in the air cavity (47), and the piston (48) is connected to a clamping block (49).

10. The working method of a biological reagent reaction device according to claim 9, characterized in that: The specific steps of this working method are as follows: Step 1: Move the multi-layer trolley equipped with the test tube rack to one of the loading and unloading mechanisms (1), move another vacant multi-layer trolley to another loading and unloading mechanism (1), drive one of the first synchronous wheels (13) to rotate by the first motor (15), realize the rotation of the first threaded rod (11) through the transmission of the first synchronous wheel (13) and the first synchronous belt (14), drive the lifting platform (4) to rise and fall corresponding to each layer of the multi-layer trolley, drive the second threaded rod (17) to rotate by the second motor (16), and then drive the threadedly connected slide (6) to move to the outer end of the translation frame (5), at which time the rotating rod (8) and The clamping rod (10) moves to both sides of the test tube rack, and the clamping rod (10) is driven by the first pneumatic cylinder (9) to move and clamp the test tube rack, and then the slide (6) moves to the inner end of the translation frame (5), and the clamping is released. At this time, the test tube rack is moved to the lifting platform (4), and the height of the lifting platform (4) is adjusted to be flush with the platform (19). The third motor (18) drives the rotating rod (8) and the clamping rod (10) to rotate 180 degrees, and then the slide (6) moves to the outer end of the translation frame (5). At this time, the clamping rod (10) is moved to clamp the test tube rack again, and then the slide (6) moves to the inner end of the translation frame (5) again, and the test tube rack moves to the platform (19); Step 2: The fourth motor (31) drives the third threaded rod (32) to rotate, thereby driving the threadedly connected transverse adjustment frame (21) to rise and fall, the fifth motor (33) drives the fourth threaded rod (34) to rotate, thereby driving the threadedly connected slider (22) to move horizontally, and the sixth motor (36) drives the fifth threaded rod (35) to rotate, thereby realizing the merging and separation of the clamping seat (24), moving the clamping seat (24) to both sides of the longitudinal test tube of the test tube rack, and then the two clamping seats (24) are merged to clamp the longitudinal test tube through the clamping groove (25), at this time, the second pneumatic cylinder (38) drives the rotating ring (39) and the rotating plate (26) to move downward, and the screw capping cylinder (28) of the mounting frame seat (27) is covered on the test tube cover, and then the clamping seat (24) is moved to the test tube cover. The pressure in the air cavity (47) drives the piston (48) and the clamping block (49) to move, thereby clamping and fixing the test tube cover. The eighth motor (44) drives the second synchronous wheel (45) to rotate, and drives one of the capping cylinders (28) to rotate through the third synchronous belt (46). The capping cylinders (28) rotate together through the second synchronous belt (43), thereby screwing off the test tube cover on the test tube. Then, the rotating plate (26) moves downward, and the test tube cover is separated from the test tube. The seventh motor (37) drives the rotating plate (26) to rotate, and the support plate (29) and the reagent injection nozzle (30) are rotated onto the test tube. Then, the reagent injection nozzle (30) adds reagent into the test tube for reaction. After the reaction is completed, the test tube cover is installed on the test tube. Step 3: The test tube racks on the platform (19) are moved to an empty multi-layer trolley in sequence by another loading and unloading mechanism (1). At the same time, the test tube racks on different layers of the multi-layer trolley are moved to the platform (19) in sequence by the loading and unloading mechanism (1) for reagent reaction.

Citation Information

Patent Citations

  • Liquid adding robot and liquid adding method

    CN112191289A

  • Automatic liquid injection and uniform mixing equipment

    CN115253819A

  • Sample injection system of full-automatic blood coagulation analyzer and use method of sample injection system

    CN116413457A

  • Automatic sampling device

    CN116769574A

  • All-time non-stop automatic feeding device

    CN209701766U