Method for automatically performing hypoxia training

Abstract

The invention relates to a method for automatically carrying out hypoxia training, comprising the following method steps: acquiring a first measured value or inputting a first parameter, acquiring a second measured value or inputting a second parameter, determining a training parameter from the first acquired measured value and / or the first input parameter and the second acquired measured value and / or the second input parameter, creating a hypoxia training procedure and / or performing hypoxia training with the determined training parameters, where the training parameters include one or more parameters from the group of duration of a hypoxia interval, number of cycles of the hypoxia interval, and minimum oxygen content of the breathing air mixture provided during the hypoxia training, and wherein at least one value of one of the two training parameters is at least 1% and at most 25% higher or lower than a value of the training parameter, which value can be determined solely by the first acquired measured value and / or the first input parameter or solely by the second acquired measured value and / or the second input parameter.

Description

[0001] The present invention relates to a method for automatically performing hypoxic training, which has the following method steps: acquiring a first measured value or inputting a first parameter, acquiring a second measured value or inputting a second parameter, determining training parameters from the first acquired measured value and / or the first input parameter and the second acquired measured value and / or the second input parameter, creating a hypoxic training program and / or performing hypoxic training using the determined training parameters, wherein the training parameters include one or more parameters from the group consisting of the duration of a hypoxic interval, the number of cycles of the hypoxic interval and the minimum oxygen content of a breathing air mixture provided during the hypoxic training, and wherein at least one value of one of the two training parameters is at least 1% and at most 25% higher or lower than the value of the training parameter, and the value of the training parameter can be determined only by the first acquired measured value and / or the first input parameter or only by the second acquired measured value and / or the second input parameter. Prior art

[0002] Hypoxia can cause a reaction in any cell in the body and can increase energy metabolism. Hypoxia can promote the activation of many genes. Athletes, healthy people and patients may benefit from hypoxia.

[0003] It has long been known that altitude training has beneficial effects. However, it was not until a few years ago that it was fully explained how a mild lack of oxygen leads to improvements in physical function. The observed increase in red blood cells was not enough to explain the changes in the body. A breakthrough in understanding came with the discovery of the hypoxia-inducible factor HIF-1-α. This provided an explanation for the combined effects of altitude training. The abbreviation HIF stands for hypoxia-inducible factor. Behind the technical term is an oxygen sensor that becomes active when there is not enough oxygen in the body's cells. It controls one of the most important survival processes in the body: the adaptation of cells, tissues and organs to lack of oxygen. At the same time, it is a signal for the body to repair itself.

[0004] The best-known positive effect of HIF is the synthesis of erythropoietin (EPO) in the kidneys and liver. It helps to explain the changes in the cardiovascular, respiratory and hematological systems before the discovery of HIF. Now it is clear that the functional improvements are more comprehensive. The endothelial cells of the intima respond to the effects of hypoxia by increasing the synthesis of nitric oxide (NO). The gas has a decisive influence on the dilation of blood vessels. It leaves the endothelium and has a relaxing effect on the smooth muscle cells in the surrounding tissue. In the intima itself, NO prevents platelet adhesion and aggregation. In this context, the formation of the angiogenic factor VEGF by endothelial cells under the influence of hypoxia is also of interest. As a result of its formation, new blood vessel formation of capillaries occurs in the case of hypoxic therapy. Usually, these additional blood vessels are located in damaged or poorly perfused tissue sections.

[0005] The heartbeat increases, people breathe more frequently. The body tries to absorb as much oxygen as possible from the air they breathe. For humans, this is neither unpleasant nor dangerous. Blood vessels widen, and blood can flow faster. The number of red blood cells rises, and the body can absorb more oxygen molecules. The supply to all organs improves. In addition, the body begins to adjust its procedures. Under the influence of the hypoxia factor HIF-1-alpha, the body takes all precautions even when there is less oxygen.

[0006] Mitochondria become dense and regenerate. Energy production is optimized, which leads to more physical and mental performance in everyday life. People with diseases, symptoms are reduced. In the brain, the transmission of nerve impulses is improved. In some areas, new nerve cells develop. As a result, mental strength increases, the risk of dementia and Parkinson's disease decreases. The network of blood vessels becomes denser. The inner wall of the blood vessels becomes smooth and soft. This reduces the chances of dangerous blood clots, as well as reducing the risk of heart attacks and strokes.

[0007] On the other hand, hypoxia can lead to loss of concentration, fatigue, and ultimately loss of consciousness, which can cause significant harm. Therefore, the optimal training procedure must take into account the individual limitations of each person being trained, so that it is safe for the subject, but also in an area where the organism can be optimally processed and the training is effective.

[0008] Therefore, the object of the present invention is to provide a method for automatically performing hypoxic training, which enables safe and at the same time effective performance of hypoxic training. In addition, the object of the present invention is to provide training parameters for different parameters, which ensure safe and at the same time effective performance of hypoxic training.

[0009] The above object is achieved by a method for automatically performing hypoxic training according to claim 1. Further advantageous configurations of the invention are set forth in the dependent claims.

[0010] The method according to the invention for automatically performing hypoxic training has four method steps: In a first method step, a first measurement value is acquired or a first parameter is input. In a second method step, a second measurement value is acquired or a second parameter is input. The first method step and / or the second method step are usually performed under medical supervision as part of an initial test of the user. The initial test objectively determines the sensitivity of the user's body to hypoxic stimuli. The initial test is used to adjust the intensity of the hypoxic training according to the needs of the user. Acquiring the measurement values ​​makes it possible to detect outliers and incorrect measurement results, which may cause possible harm to the patient during the hypoxic training when selecting to determine the training parameters.

[0011] In a third method step, training parameters are determined from the first acquired measured values ​​and / or the first input parameters and from the second acquired measured values ​​and / or the second input parameters.

[0012] In a fourth method step, a hypoxic training program is created and / or a hypoxic training is performed with specific training parameters. The training parameters include one or more parameters from the group consisting of the duration of the hypoxic intervals, the number of cycles of the hypoxic intervals, the minimum oxygen content of the breathing air mixture provided during the hypoxic training and / or the length of the rest between the hypoxic intervals. The training program is automatically created, i.e. the measured values ​​and the input parameters are automatically converted into the training program.

[0013] With the setting options for the training parameters duration, number of cycles, oxygen content in the blood and oxygen saturation, hypoxic training is optimally adapted to the needs of the user. Based on the acquisition of measured values ​​and the input parameters, the reduction of oxygen in the breathing air allows for the highest effectiveness and maximum safety during training.

[0014] These training parameters are selected in such a way that all adaptation processes in the body are triggered, but the intentionally induced hypoxia may not cause damage. To this end, at least one value of one of the two training parameters is at least 1% and at most 25% higher or lower than the value of the training parameter, the value of which can be determined only by the first acquired measurement value and / or the first input parameter or only by the second acquired measurement value and / or the second input parameter. Here, the training parameter is oriented towards promoting training conditions, that is, higher than the target value of the oxygen saturation in the blood, higher than the oxygen content in the breathing gas, lower than the length of the hypoxic intervals, higher than the length of the intervals between the hypoxic intervals, lower than the number of repetitions by 1% to 25%. Preferably, the training parameter is a parameter with a facilitating training condition, that is, higher than the target value of the oxygen saturation in the blood, higher than the oxygen content in the breathing gas, lower than the length of the hypoxic interval, higher than the interval length between the hypoxic intervals, and 1% to 25% lower than the number of repetitions, which comes only from the first acquired measurement value and / or the first input parameter or only from the second acquired measurement value and / or the second input parameter. This tolerance of parameter deviation ensures that the user safely performs the hypoxic training program while achieving a very high training effect. Many tests have shown that training programs with training parameters in this area avoid oxygen deficiency that harms the organism, but are still in the area where the training is effective. In a preferred embodiment of the present invention, at least one value of one of the two training parameters is at least 1% and at most 20% higher or lower than the value of the training parameter, preferably at least 1% and at most 15%, particularly preferably at least 1% and at most 10%, the value of which can be determined only by the first acquired measurement value and / or the first input parameter or only by the second acquired measurement value and / or the second input parameter.

[0015] In a refinement of the invention, the value of a training parameter is at least 1.5% and at most 8% higher or lower than the value of the training parameter. In another aspect of the invention, the value of a training parameter is at least 2% and at most 7% higher or lower than the value of the training parameter. Other tolerances are conceivable, for example at least 3% and at most 7.5%, at least 4% and at most 7%, depending on the acquired measurements of the user. The tolerance is selected to be as small as possible in order to achieve effective hypoxic training, but at the same time large enough to make the hypoxic training safe for the user.

[0016] In another embodiment of the invention, the value of one training parameter is set independently of the result of obtaining the measured values ​​and / or input parameters. The other training parameters are modified accordingly. Thus, only one training parameter is varied, while the other training parameter is set according to the measured values ​​and / or input parameters and is immutable.

[0017] In another embodiment of the invention, the first process step and the second process step are carried out at different time points, preferably at least 10 minutes apart, more preferably at least 30 minutes apart, even more preferably at least 24 hours apart. By moving the time points, incorrect measurement results can be found, for example, incorrect measurement results caused by deviations from normal physical deviations and / or physical irregularities.

[0018] In another embodiment of the invention, the first process step and / or the second process step and the third process step and / or the fourth process step are performed at different time points, preferably at least 10 minutes apart, more preferably at least 30 minutes apart, even more preferably at least 24 hours apart. The determination of training parameters and / or the creation and / or execution of a hypoxic training program cannot be compared with the monitoring and adaptation of an already created hypoxic training program during the execution of the hypoxic training program.

[0019] In another configuration of the invention, the training parameters are newly determined. The training parameters are created independently of previously created training parameters and / or hypoxia training programs already performed for the same subject.

[0020] In another configuration of the invention, at least one training parameter is the duration of the hypoxic interval and / or the minimum oxygen content of the breathing air mixture provided during the hypoxic training. With these two training parameters, the hypoxic training is tailored to the needs of the user. These training parameters are determined in such a way that all adaptation processes in the body are triggered, but the intentionally induced hypoxia does not cause damage.

[0021] In an advantageous embodiment of the invention, the hypoxia training program is automatically created. This makes the hypoxia training program reproducible, reduces sources of human error to a minimum, and allows the hypoxia training program to be created cost-effectively.

[0022] In a further advantageous configuration of the invention, the hypoxia training program is automatically performed. Thus, in particular if the user wears a monitoring device, such as a pulse oximeter, the hypoxia training program can be performed cost-effectively for the user.

[0023] In another embodiment of the invention, the measured values ​​and / or input parameters include SI values ​​for heart rate variability measurement, time of breath-hold test, results of MitoOx test, results of MDA-LDL test, dosage determination according to Professor Apanasenko, results from tests of basal respiration, ATP production, proton leak, maximal respiration, reserve capacity and / or non-mitochondrial respiration.

[0024] Heart rate variability can be used to measure the patient's physical resilience. It is recommended to measure it before and during hypoxic training.

[0025] Heart rate variability (HRV) can be used to measure the general adaptability of an organism. This measurement provides an assessment of how well the autonomic nervous system can react to stressful influences through its two components (the sympathetic nervous system and the parasympathetic nervous system). HRV values ​​are meaningful for hypoxic training because they provide information about the regulatory capacity of the autonomic nervous system. The flexibility of the autonomic nervous system is important when planning the duration of the intervals. They can be used for control during the training process.

[0026] The SI value contains various HRV parameters. The size of the SI can be used to estimate the balance between the activity of the sympathetic and parasympathetic nervous systems. A higher SI value indicates tightness of the regulatory system and lower relaxation capacity.

[0027] The result of the breath-hold test provides a first indication of the possible depth of hypoxia. It also provides information about the load capacity during the training session. There are different breath-hold tests, the Stange and Genchi tests are just two of them. They provide the same information and differ only in the method, which attracts the attention of different patient groups. Both tests are performed before the first hypoxic training session and after the completion of the hypoxic therapy course. The results of the test with a longer breath-hold time confirm the correct dosage and the positive effect of hypoxia.

[0028] Whenever possible, mitochondrial pool analysis should be performed in all patients. For a long time, the assessment of mitochondrial function was only available indirectly and was associated with high costs for the patient. A new approach is the assessment of mitochondrial DNA (mtDNA) from a drop of blood by the MitoOx test. Any changes, from minor point mutations to the loss of larger fragments of mtDNA (deletions), affect the mitochondrial respiratory chain. The MitoOx test provides a determination of the most common deletion of 4977 bp (common deletion). It contains base pairs 8470 to 13447 and affects about one third of the total mitochondrial genome. Complexes I, IV and V of the respiratory chain are affected by the mutation. The number of deletions of 4977 bp increases with increasing oxidative load.

[0029] The MitoOx test compares the number of healthy mitochondrial gene copies to the number of damaged gene copies. The higher the number of healthy mitochondrial gene copies, the lower the oxidative load or the higher the antioxidant capacity. If the proportion of copies with the 4977 bp deletion increases, it can be considered that the mitochondrial function is reduced.

[0030] For hypoxic training, this means that the hyperoxic period was counterproductive in patients with the cumulative 4977 bp deletion. The elevated oxygen levels further increased oxidative stress. In patients with mitochondrial dysfunction, the switch between hypoxic and hyperoxic periods could lead to further deterioration of mitochondria.

[0031] Most chronic diseases are associated with mitochondrial dysfunction. The Bioenergetic Health Index (BHI) examines the function of individual converter cells in the respiratory chain and assesses the bioenergetic quality of the mitochondria. Six parameters can be used to identify weaknesses and determine the degree of dysfunction or mitochondrial efficiency. Other acquired measurements and / or input parameters include results from tests of basal respiration, ATP production, proton leak, maximal respiration, reserve capacity, and / or non-mitochondrial respiration.

[0032] In another embodiment of the present invention, the training parameters are checked before the training program is created. During the check, the training parameters are compared with the values ​​measured in real time (such as the oxygen concentration in the user's breathing gas, blood oxygen saturation and heart rate).

[0033] In another embodiment of the invention, the training parameters are changed before creating the training program. If the determined training parameters are within the range expected during the initial test, the training program is created and the training plan is started with the determined training parameters. If the determined training parameters are not within the range expected during the initial test, the training parameters are changed in such a way that, for example, the measured values ​​of oxygen concentration in the breathing gas, blood oxygen saturation and heart rate will be within the expected range again. A new training plan with the changed training parameters is then created and started with the changed training parameters. By checking the training parameters and, if necessary, changing them in real time, safe and at the same time effective hypoxic training is achieved.

[0034] In a refinement of the invention, the created training program is created on the first computer unit. In particular, the created training program is created under medical supervision. This makes the hypoxia training program reproducible, reduces human error sources to a minimum, and allows the hypoxia training program to be created cost-effectively.

[0035] In another embodiment of the invention, the created training program is transferred from the first computer unit to the second computer unit. The second computer unit is usually arranged remotely from the first computer unit.

[0036] In another configuration of the invention, the second computer unit comprises a controller for executing the training program. With the second computer unit, the created hypoxia training program can also be executed remotely from the first computer unit. The user can execute the created hypoxia training program, for example, in his home via the second computer unit and the controller arranged therein or connected to the second computer unit in order to execute the training program.

[0037] In another configuration of the present invention, the training parameters include the number of hypoxic cycles, the number of training sessions in a treatment course and / or the regeneration time between individual training sessions. The intensity of the training is largely determined by the number of hypoxic intervals. According to scientific findings, 4-5 cycles per training session are sufficient. Patients with poor baseline values ​​start 3 to 4 cycles of hypoxic training. After about five training sessions, the training curves are compared. Changes in HRV parameters, pulse and oxygen saturation curves are expected. For patients with a decline in general condition, intermediate tests (such as HRV measurements or breath-hold tests) can also be used to evaluate the training.

[0038] Another embodiment includes a regeneration phase in the form of repeated weekly administration. In particular, the number of repetitions increases with higher target values ​​and / or higher training parameters. This prevents heavy physical loads and allows physical adaptation during the regeneration phase.

[0039] After a number of training units, preferably after a maximum of 5 training units, even more preferably after a maximum of 2-4 training units, most preferably after each training unit, the training parameters are re-determined. In this way, effective and at the same time safe personalized hypoxic training can be ensured.

[0040] In another aspect of the invention, the method is performed in a personalized manner. Each user has an individual reaction to hypoxic training. Intermediate tests (such as heart rate variability (HRV) measurements) should be performed regularly, especially in patients with reduced general condition, to avoid overtraining. In addition, there are individual factors (such as hypoglycemic tendency and use of medications), which are included in the training plan.

[0041] In another embodiment of the invention, the training program is interrupted according to a combination of two values ​​from the acquisition of measured values ​​and / or input parameters and / or according to a single value of the acquisition of measured values ​​and / or input parameters. In particular, a safety limit (safety cutoff) in the form of a parameter of the blood oxygen saturation that leads to the interruption of the automatic training and / or the creation of the automatic training is set individually for the user. If this safety limit is not reached, the safety program is activated in such a way that the blood oxygen saturation rises again above the safety limit. This allows the user to carry out a safe training program even outside medical supervision.

[0042] In a refinement of the invention, the automatic creation and / or execution of the hypoxic training is interrupted if the training parameters determined from the first acquired measured values ​​and / or the first input parameter or only from the second acquired measured values ​​and / or the second input parameter exceed the tolerance of the parameter deviation. In this way, it can be ensured that hypoxia that is harmful to the organism is avoided.

[0043] In one embodiment, hypoxic training includes only hypoxic and hyperoxic periods in order to achieve particularly high performance gains.

[0044] In another embodiment, the hypoxic training includes only hypoxic and normoxic periods in order to reduce the load on the body. In particular, the hyperoxic periods may result in a high load on the user.

[0045] In another embodiment, the hypoxic training comprises a hyperoxic period and a normoxic period after each hypoxic period, so as to reduce the peak load of the body, especially towards the end of the training, but still to be able to improve performance. The training preferably starts with a hyperoxic period and / or in each case alternates between hyperoxic and normoxic periods after the hypoxic period. In particular, the alternation between hyperoxic and normoxic periods reduces the peak load in the hypoxic training.

[0046] An exemplary embodiment of the method according to the invention for automatically performing hypoxic training is schematically shown in a simplified manner in the drawing and is explained in more detail in the following description.

[0047] In the attached picture:

[0048] Figure 1 : Diagram showing a hypoxic-normoxic training program

[0049] Figure 2 : Diagram showing a hypoxic-hyperoxic training program

[0050] Figure 3a : Shows a detailed view of the Hypoxic-Normoxic Training Program

[0051] Figure 3b : Shows a detailed view of a hypoxic-normoxic training program with tolerances for training parameters noted

[0052] Figure 4 : A flowchart showing a method for automatically performing hypoxia training according to the present invention

[0053] Figure 1 An exemplary embodiment of a hypoxic-normoxic training program 1 performed at intervals is shown. The hypoxic intervals 100 alternate with normoxic intervals 200. In this exemplary embodiment, each interval 100, 200 has a duration of 5 minutes.

[0054] The diagram shows the oxygen concentration 10 (ordinate O2) in the breathing gas, the blood oxygen saturation 20 (ordinate SpO2), the heart rate 40 (ordinate HR) and the value of the safety limit 30 (safety cutoff value) of the blood oxygen saturation 20 SpO2 over time (abscissa). In this exemplary embodiment and all subsequent exemplary embodiments, the safety limit 30 is 80% SpO2, but can be set individually for each user. If this safety limit 30 is not reached, the safety program is activated in such a way that the blood oxygen saturation 20 rises again above the safety limit 30 of 80% SPO2.

[0055] In order to perform the method 400 for automatically performing hypoxia training 400 according to the present invention (see Figure 4 ), a plurality of measured values ​​of a user are obtained 410 through an initial test, and a plurality of parameters of the user are input 420 into a first computer unit.

[0056] Heart rate variability can be used to measure the patient's physical resilience. It is recommended to measure it before and during hypoxic training. Heart rate variability (HRV) can be used to measure the general adaptability of the organism. This measurement provides an assessment of how well the autonomic nervous system can react to stressful influences through its two components (the sympathetic nervous system and the parasympathetic nervous system). HRV values ​​are meaningful for hypoxic training because they provide information about the regulatory capacity of the autonomic nervous system. The flexibility of the autonomic nervous system is important when planning the duration of the intervals. They can be used for control during the training process.

[0057] The SI value contains various HRV parameters. The size of the SI can be used to estimate the balance between the activity of the sympathetic and parasympathetic nervous systems. A higher SI value indicates tightness of the regulatory system and lower relaxation capacity.

[0058] The result of the breath-hold test provides a first indication of the possible depth of hypoxia. It also provides information about the load capacity during the training session. There are different breath-hold tests, the Stange and Genchi tests are just two of them. They provide the same information and differ only in the method, which attracts the attention of different patient groups. Both tests are performed before the first hypoxic training session and after the completion of the hypoxic therapy course. The results of the test with a longer breath-hold time confirm the correct dosage and the positive effect of hypoxia.

[0059] Whenever possible, mitochondrial pool analysis should be performed in all patients. For a long time, the assessment of mitochondrial function was only available indirectly and was associated with high costs for the patient. A new approach is the assessment of mitochondrial DNA (mtDNA) from a drop of blood by the MitoOx test. Any changes, from minor point mutations to the loss of larger fragments of mtDNA (deletions), affect the mitochondrial respiratory chain. The MitoOx test provides a determination of the most common deletion of 4977 bp (common deletion). It contains base pairs 8470 to 13447 and affects about one third of the total mitochondrial genome. Complexes I, IV and V of the respiratory chain are affected by the mutation. The number of deletions of 4977 bp increases with increasing oxidative load.

[0060] The MitoOx test compares the number of healthy mitochondrial gene copies to the number of damaged gene copies. The higher the number of healthy mitochondrial gene copies, the lower the oxidative load or the higher the antioxidant capacity. If the proportion of copies with the 4977 bp deletion increases, it can be considered that the mitochondrial function is reduced.

[0061] Most chronic diseases are associated with mitochondrial dysfunction. The Bioenergetic Health Index (BHI) examines the function of individual converter cells in the respiratory chain and assesses the bioenergetic quality of the mitochondria. Six parameters can be used to identify weaknesses and determine the degree of dysfunction or mitochondrial efficiency. The six parameters are a test of the user's basal respiration, ATP production, proton leak, maximal respiration, reserve capacity and / or non-mitochondrial respiration. Test of basal respiration, ATP production, proton leak, maximal respiration, reserve capacity and / or non-mitochondrial respiration.

[0062] From these measured values ​​and input parameters, training parameters are determined 430. The training parameters include the duration of the hypoxic interval 100, the duration of the normoxic interval 200, the number of cycles of the hypoxic interval and the minimum oxygen content 10 of the breathing air mixture provided during the hypoxic training. The hypoxic period 100 is individually adjustable by setting options for the duration and frequency of the intervals 100, 200, the oxygen reduction 10 of the breathing gas and the oxygen saturation 20 in the blood.

[0063] These training parameters are selected for the user in an individualized manner so that all adaptation processes in the body are triggered, but the intentionally induced hypoxia may not cause damage. The training program 1 thus created is then transmitted to a second computer unit having a controller for executing the training program 1. Subsequently, the training program 1 is executed 460 on a suitable training device.

[0064] For example, if during the breath-hold test according to Stange / Genchi a value of 40 / 45 seconds is achieved, during laboratory tests (MitoOx test, MDA-LDL) a value of MitoOx > 10 8 :1, normal to slightly elevated MDA-LDL, BHI>2.0, values ​​of both parameters>15 points during the dose determination according to Professor Apanasenko, then hypoxic training can be performed with training parameters relative to a target value of 80-82 SpO2, the duration of the hypoxic period is at least 5 minutes, with 6 cycles, can be performed up to 3 times a week, and each treatment course includes 10-14 training units.

[0065] For example, if during the breath-hold test according to Stange / Genchi a value of 25-40 / 30-45 seconds is achieved, during laboratory tests (MitoOx test, MDA-LDL) the value of MitoOx is 10 8:1, mild increase in MDA-LDL, BHI 2.0-1.5, values ​​of both parameters during dosage determination according to Professor Apanasenko are 10-15 points, then hypoxic training can be performed with training parameters relative to a target value of 83-84SpO2, the duration of the hypoxic period is at least 4 minutes, with 5 cycles, can be performed up to 3 times a week, and each treatment course includes 15-20 training units.

[0066] For example, if during the breath-hold test according to Stange / Genchi a value of 10-24 / 15-29 seconds is achieved, during laboratory tests (MitoOx test, MDA-LDL) a value of 10 7 To>10 5 :1, mild to marked increase in MDA-LDL, BHI <1.5, values ​​of both parameters during dosage determination according to Professor Apanasenko are 4-6 points, then hypoxic training can be performed with training parameters relative to a target value of 85-87 SpO2, the duration of the hypoxic period is at least 3 minutes, with 4 cycles, can be performed up to 3 times a week, and each treatment course includes 15-20 training units.

[0067] In one embodiment, parameters from different tests may be combined with each other to determine training parameters.

[0068] For example, if during a breath-hold test according to Stange / Genchi, for one parameter a value is reached within 40 / 45 seconds and a value is between 25-40 / 30-45 seconds, one parameter comprises training parameters for a target value of 80-82 SpO2 and the other parameter comprises training parameters for a target value of 83-85. These values ​​do not exceed the tolerance of the deviation parameter, but to ensure the safety of the user, the training parameters for the smaller target value are used as the basis for hypoxic training, the duration of the hypoxic period is 4-5 minutes, there are 5 cycles, it can be performed up to 3 times a week, and each treatment course comprises 15-20 training units.

[0069] Training program 1 starts with a hypoxic interval 100, which ends after 5 minutes with a blood oxygen saturation of 85% 20. The blood oxygen saturation 20 below 85% depends on the health and fitness status of the user and the results of the initial test.

[0070] The curve of the heart rate 40 is inversely proportional to the curve of the oxygen concentration 10 in the breathing gas. In the hypoxic period, the heart rate 40 increases, while in the normoxic or hyperoxic period, the heart rate 40 decreases again.

[0071] Each hypoxic interval 100 is followed by a normoxic interval 200 with oxygen-enriched or normally saturated room air 200. In this exemplary embodiment, the length of the normoxic interval 200 is also 5 min. For the body, the normoxic interval 200 is like rest. The heart rate 40 slows down again, and the blood oxygen saturation 20 rises again to 99%.

[0072] Figure 2 An exemplary embodiment of a hypoxic-hyperoxic training program 1 is shown which is also performed at intervals. The hypoxic intervals 100 alternate with hyperoxic intervals 300. In this exemplary embodiment, each hypoxic interval 100 has a duration of 5 minutes.

[0073] On the other hand, the diagram shows the values ​​of the oxygen concentration 10 (ordinate O2) in the breathing gas, the blood oxygen saturation 20 (ordinate SpO2), the heart rate 40 (ordinate HR) and the safety limit 30 (safety cutoff value) of the blood oxygen saturation 20 SpO2 over time (abscissa).

[0074] If hypoxic intervals 100 are alternated with slightly elevated hyperoxic periods 300 (oxygen concentration 10 in the breathing gas from 25% to 35%), these values ​​normalize more quickly than normoxic periods 200 (see Figure 1 ) Because the body can increase blood oxygen saturation 20 more quickly during the hyperoxic period 300, the duration of the hyperoxic period 300 is shorter than the normoxic period 100, which is 3 minutes in this exemplary embodiment.

[0075] Many users estimate that the relaxation effect of the hyperoxic period 300 is higher than that of the normoxic period 100. However, physiologically, the hyperoxic period 300 is as taxing on the body as the hypoxic period 100, because it triggers another stress stimulus in the body. The increase in the oxygen supply 10 in the breathing gas leads to a greater load and stimulation of the body's own antioxidant systems. Oxidative stress increases. Therefore, the hypoxic-hyperoxic training 1 may be unbearable for users with impaired health.

[0076] Scientific research and the experience of the past four decades have shown that it is the short-term decrease of 20% oxygen saturation and the variation between normal oxygen saturation 20% that brings the best health effects. In contrast, a longer decrease of 20% oxygen saturation, equivalent to a long stay on the mountain or in a hypoxic chamber, will have a lower training effect. More frequent variations lead to an additional stimulus for physical adaptation. The comparison of different training programs has led to the recommendation of 4-5 cycles with hypoxic intervals of 100 for 5-7 minutes, followed by normoxic intervals of 200 or hyperoxic intervals of 300.

[0077] Figure 3a and Figure 3b A detailed view of an exemplary embodiment of a hypoxic-normoxic training program 1 is shown. Figure 3b Shows Figure 3a A is an enlarged portion of the diagram in FIG. On the other hand, Figure 3a and Figure 3b The diagram shown in FIG. 1 shows the values ​​of the oxygen concentration 10 (ordinate O2) in the breathing gas, the blood oxygen saturation 20 (ordinate SpO2), the heart rate 40 (ordinate HR), and the safety limit 30 (safety cutoff value) of the blood oxygen saturation 20SpO2 over time (abscissa). In this exemplary embodiment and all subsequent exemplary embodiments, the safety limit 30 is 80% SpO2,

[0078] According to the invention, the duration of the training parameter hypoxic interval 100 is adjusted in such a way that ( Figure 3b ), so that the value of the minimum oxygen content 10 of the breathing air mixture provided by the training parameters during the hypoxic training is at least 1% higher or lower than that of the minimum oxygen content 10 of the breathing air mixture provided by the training parameters during the hypoxic training, in particular so that the blood oxygen saturation 20 ( Figure 3a ) is always above the safety limit of 30.

[0079] also, Figure 3b The diagram in the figure shows the training parameters determined by the results or input parameters of the preliminary examination, the length of the hypoxic interval and the oxygen content in the breathing gas. When measuring the heart rate variability at rest, an RMSSD of 38 ms, a MitoOx of 1.5*10^8 and a BHI value of 1.9 were measured. In addition, the breath-hold test showed a time of 41 s.

[0080] The minimum target blood oxygen saturation SpO2 70 determined solely by the measurement of heart rate variability is 82.5%. The range 72 of the oxygen saturation SpO2 in the blood has a minimum value 71 of 83.5% and a maximum value 73 of 88.5%. The maximum length 80 of the hypoxic interval determined solely by the measurement of heart rate variability corresponds to 312 s. The range 82 of the length of the hypoxic interval has a maximum length 81 of 308 s and a minimum length 83 of 270 s. The oxygen content 90 in the breathing gas determined solely by the measurement of heart rate variability is 12.25%. The range 92 of the oxygen content in the breathing gas has a minimum value 91 of 12.4% and a maximum value 93 of 13.5%. The training parameters automatically determined from all the measured values ​​are: for the target value 74 of the blood oxygen saturation, SpO2 = 84%; for the length 84 of the hypoxic interval, 300 s; and for the oxygen content in the breathing gas, 12.5%. The training is then performed with these training parameters. All training parameters are selected so that they are within a range between 1% and 25% higher or lower than the measured values ​​and / or input parameters of the preliminary check. In this case, all automatically determined training parameters 74, 84, 94 are oriented toward more relaxed training conditions, higher or lower than the training parameters 70, 80, 90 determined by the measured values ​​and / or input parameters of the preliminary check.

[0081] In other embodiments, the automatically determined training parameter is at least 1.5% and at most 8%, at least 2% and at most 7% higher or lower than the value of the training parameter determined by one of the measured values ​​and / or the input parameters. Other tolerances are conceivable, such as at least 3% and at most 7.5%, at least 4% and at most 7%, depending on the user's acquired measurements. In this exemplary embodiment, the tolerance is at least 2% and at most 25%.

[0082] In this way, a training program can be automatically created without putting the user at risk of lack of oxygen supply, but still performing the training within the range that will hopefully result in successful training. Without this method, automatically creating a training program without risk would be impossible for a large number of users.

[0083] The safety limit 30 is determined and set for each user individually. In this exemplary embodiment, it is set using the blood oxygen saturation 20 minus 2%. When the training intensity is set correctly, during the hypoxic period 100, the blood oxygen saturation 20 remains 2% to 3% higher than the safety limit 30.

[0084] According to an exemplary embodiment of the method 400 for automatically performing hypoxia training of the present invention, Figure 4 In a first method step, a plurality of measured values ​​of a user are acquired 410 by means of an initial test, and a plurality of parameters of the user are input 420 into a first computer unit.

[0085] From these acquired measured values ​​and input parameters, training parameters are determined 430. The training parameters include the duration of the hypoxic interval 100, the number of cycles of the hypoxic interval 100 and the minimum oxygen content 10 of the breathing air mixture provided during the hypoxic training. The hypoxic period 100 is individually adjustable via setting options for duration 100, frequency, oxygen reduction 10 of the breathing gas and oxygen saturation 20 in the blood.

[0086] In a further method step, the training parameters duration of the hypoxic interval 100, number of cycles of the hypoxic interval 100 and minimum oxygen content 10 of the breathing air mixture provided during the hypoxic training are tested 440. The user wears a pulse oximeter during the entire intermittent hypoxic training 1. The pulse oximeter is directly connected to the hypoxic device for performing the hypoxic training 1. The hypoxic device has a second computer unit with a memory or is connected to such a unit. During the test 440, the training parameters duration of the hypoxic interval 100, number of cycles of the hypoxic interval 100 and minimum oxygen content 10 of the breathing air mixture provided during the hypoxic training are compared with the real-time measured values ​​of the oxygen concentration 10 in the breathing gas, the blood oxygen saturation 20, the heart rate 40 and the safety limit 30 of the blood oxygen saturation 20.

[0087] If the determined training parameters are within the range expected during the initial test and have not fallen below the safety limit 30 for the blood oxygen saturation 20, in a following method step 450 a training plan is created 450 and the training plan is started 460 with the determined training parameters. If the determined training parameters are not within the range expected during the initial test and / or the safety limit 30 for the blood oxygen saturation 20 has not been reached, the training parameters are changed 470 in such a way that the measured values ​​of the oxygen concentration 10 in the breathing gas, the blood oxygen saturation 20 and the heart rate 40 are again within the expected range and the safety limit 30 for the blood oxygen saturation 20 is again exceeded. A new training plan with the changed training parameters is then created 480 and started 490 with the changed training parameters. By checking the training parameters and, if necessary, changing them in real time, a safe and at the same time effective hypoxic training is achieved.

[0088] List of reference numbers 1 Training Program / Training Plan 10 Oxygen concentration in breathing gas 20 Blood oxygen saturation 30 Safety limit of blood oxygen saturation 40 Heart rate 50 High oxygen range of blood oxygen saturation 80 Maximum length of the hypoxic interval determined by measurements or input parameters 81 Maximum length of hypoxic interval 82 Length range of hypoxic intervals 83 Minimum length of hypoxic interval 84 The length of the hypoxic intervals in the training program is automatically determined and executed 90 Oxygen content of the breathing gas determined from measured values ​​or input parameters 91 Lower limit of oxygen content of breathing gas 92 Breathing gas oxygen content range 93 Upper limit of oxygen content of breathing gas 94 Automatic determination and execution of the oxygen content of the breathing gas during the training program 100 Hypoxic interval 200 Normoxic interval 300 Hyperoxic Interval 400 Method for automating hypoxic training 410 Get measurement values 420 Input Parameters 430 Determine training parameters 440 Test training parameters 450 Create a training plan 460 Start a training program 470 Changing training parameters 480 Creating a training plan with changed parameters 490 Start the training program with the changed parameters

Claims

1. A method (400) for automatically performing hypoxia training, comprising the following method steps: - Obtaining a first measurement value (410) or inputting a first parameter (420) - Obtain a second measurement value (410) or input a second parameter (420) - determining (430) training parameters from the first acquired measurement value and / or the first input parameter and the second acquired measurement value and / or the second input parameter, - creating (450) a hypoxic training program (1) and / or performing (460) a hypoxic training with the determined training parameters, wherein the training parameters comprise one or more parameters from the group consisting of a duration of a hypoxic interval (100), a number of cycles of the hypoxic interval and a minimum oxygen content (10) of a breathing air mixture provided during the hypoxic training, Wherein at least one value of one of the two training parameters is at least 1% and at most 25% higher or lower than the value of the training parameter, and the value of the training parameter can be determined only by the first acquired measurement value and / or the first input parameter or only by the second acquired measurement value and / or the second input parameter.

2. The method (400) for automatically performing hypoxia training according to claim 1, Features The value of the one training parameter is at least 1.5% and at most 8% higher or lower than the value of the training parameter.

3. The method (400) for automatically performing hypoxia training according to claim 1 or 2, Features The value of the one training parameter is at least 2% higher or lower than the value of the training parameter by at most 7%.

4. Method (400) for automatically performing hypoxic training according to one or more of the preceding claims Features The value of the one training parameter is determined independently of the results of the measured values ​​and / or input parameters.

5. Method (400) for automatically performing hypoxic training according to one or more of the preceding claims Features The at least one training parameter is the duration of a hypoxic interval (100) and / or the minimum oxygen content (10) of a breathing air mixture provided during the hypoxic training.

6. Method (400) for automatically performing hypoxic training according to one or more of the preceding claims Features The hypoxia training program (1) is automatically created (450, 480).

7. Method (400) for automatically performing hypoxic training according to one or more of the preceding claims Features The hypoxia training program (1) is automatically executed (460, 490).

8. Method (400) for automatically performing hypoxic training according to one or more of the preceding claims Features The measured values ​​and / or input parameters include SI values ​​for heart rate variability measurement, time of breath-hold test, results of MinOx test, results of MDA-LDL test, dose determination according to Professor Apanasenko, results from tests of basal respiration, ATP production, proton leak, maximal respiration, reserve capacity and / or non-mitochondrial respiration.

9. Method (400) for automatically performing hypoxic training according to one or more of the preceding claims Features The created training program (1) is created on a first computer unit (450, 480).

10. Method (400) for automatically performing hypoxic training according to one or more of the preceding claims Features The created training program (1) is transferred from the first computer unit to the second computer unit.

11. Method (400) for automatically performing hypoxic training according to one or more of the preceding claims Features The second computer unit includes a controller for executing (460, 490) the training program.

12. Method (400) for automatically performing hypoxic training according to one or more of the preceding claims Features The training parameters include the number of hypoxic cycles, the number of training sessions in a treatment course, and / or the regeneration time between individual training sessions.

13. Method (400) for automatically performing hypoxic training according to one or more of the preceding claims Features The method (400) is performed in a personalized manner.

14. Method (400) for automatically performing hypoxic training according to one or more of the preceding claims Features The training procedure (1) is interrupted depending on a combination of two values ​​from the acquired measured values ​​and / or input parameters and / or depending on a single value of the acquired measured values ​​and / or input parameters.

15. Method (400) for automatically performing hypoxic training according to one or more of the preceding claims Features The acquired measurements and / or input parameters leading to interruption of the execution of the hypoxic training and / or creation of the hypoxic training program include SI values ​​of heart rate variability measurement, duration of a breath-hold test, results of a MinOx test, dose determination according to Professor Apanasenko, results from tests of basal respiration, ATP production, proton leak, maximal respiration, reserve capacity and / or non-mitochondrial respiration.

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