Oral liquid with functions of dispelling effects of alcohol and protecting liver as well as preparation method and oral liquid packaging bottle of oral liquid

By using oral liquid for liver protection composed of natural foods such as prickly pears, and using packaging design that separates storage and mixes, the existing products are difficult to meet the needs of conventional alcohol protection and inconvenience, achieving efficient alcohol protection and portability.

CN119699574APending Publication Date: 2025-03-28GUIZHOU INST OF BIOTECHNOLOGY (GUIZHOU KEY LAB OF BIOTECHNOLOGY GUIZHOU POTATO RES INST GUIZHOU FOOD PROCESSING RES INST)
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Patent Information

Application Number
CN202510020866.7
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-01-07
Publication Date
2025-03-28

AI Technical Summary

Technical Problem

The existing alcohol-relieving liver protection products are difficult to meet the needs of conventional alcohol-relieving wine, and are mostly inconvenient to carry, and lack efficient and portable products.

Method used

A oral solution for liver-protecting liver function is used, and its composition includes natural foods such as prickly pear, Dendrobium officinalis, Citrus cerevisiae, Pueraria root, Cornus, Chicory, Hawthorn and Polygonatum. Through specific preparation methods and packaging design, it ensures that liquid A and liquid B are stored separately and mixed when consumed.

Benefits of technology

It has achieved efficient anti-alcohol liver protection function, rich active ingredients and good taste, and the product is easy to carry through innovative packaging design, improving the consumer experience.

✦ Generated by Eureka AI based on patent content.

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Abstract

The invention discloses oral liquid with functions of dispelling effects of alcohol and protecting liver as well as a preparation method and an oral liquid packaging bottle of the oral liquid. The selected materials comprise roxburgh rose, dendrobium officinale, hovenia dulcis thunb, radix puerariae, dogwood, chicory, hawthorn, rhizoma polygonati, osmanthus fragrans and the like which have homology of medicine and food. The optimal formula combination is obtained through a large number of experimental products, and the tea has good taste, flavor, tissue form and color. The product is rich in active ingredients such as flavonoids, polysaccharides, alkaloids, polyphenols, SOD (superoxide dismutase) and the like, and the active ingredients can effectively enhance the activity of ethanol dehydrogenase (ADH) in a body and antioxidant enzymes such as SOD, GSH-Px and the like in liver tissues, reduce the content of serum and MDA (malondialdehyde) in the liver tissues and scavenge free radicals. Therefore, the oral liquid has the effects of promoting liver detoxification, remarkably improving the decomposition capability of a human body on alcohol and relieving the bad state after drinking. Different functional liquids are prepared and stored according to the characteristics of the oral liquid, the effect is ensured, and the style is novel.
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Description

Technical Field

[0001] The invention relates to the technical field of compound alcohol-relief and liver-protection oral liquid, and more particularly to an alcohol-relief and liver-protection oral liquid, a preparation method thereof and an oral liquid packaging bottle. Background Art

[0002] Wine culture has a long history, and wine has been loved by the general public since ancient times. In today's society, drinking alcohol for social events, festivals, gatherings with friends and relatives, and a drink during meals has become a normal thing. After entering the human body, alcohol will be quickly absorbed and accumulated in the blood and various tissues (especially brain tissue, whose alcohol concentration is about 10 times that of blood). Only a very small amount of alcohol can be directly excreted from the body, and most of it still needs to be metabolized by the liver. Acute excessive drinking can cause symptoms such as headaches, dizziness, vomiting, inattention, memory loss, and emotional instability. Alcohol has both advantages and disadvantages for the body. The key lies in the amount of alcohol consumed. The body absorbs a certain amount of alcohol, but people who drink often exceed the scope of quantity. Excessive alcohol will damage the stomach and increase the burden of liver detoxification. Long-term drinking will cause permanent liver damage.

[0003] Currently, there are many kinds of products for sobering up and protecting the liver, most of which are medicines or hormone medicines. Many medicines, fruits, Chinese medicines, etc. have certain sobering up effects, but products with different sobering up formulas have different effects on sobering up. Existing products are difficult to meet conventional sobering up needs and are inconvenient to carry. Therefore, how to provide a product with efficient sobering up and protecting the liver and easy to carry is a problem that needs to be solved urgently by technical personnel in this field. Summary of the invention

[0004] In view of this, the present invention provides an oral liquid with alcohol sobering and liver protecting functions and a preparation method thereof, and designs a packaging bottle suitable for the oral liquid according to the characteristics of the oral liquid.

[0005] To achieve the above object, the present invention adopts the following technical solution:

[0006] First, the present invention provides an oral liquid for sobering up and protecting the liver, comprising the following components in percentage by weight:

[0007] Rosa roxburghii 30%-45%, Dendrobium officinale 15%-25%, Hovenia dulcis 2%-5%, Pueraria lobata 5%-15%, Cornus officinalis 10%-15%, Chicory 5%-10%, Hawthorn 3%-20%.

[0008] Preferably, it also includes 5% to 10% of polygonatum and 8% to 15% of sugar cane.

[0009] Preferably, 0.1g to 0.5g of osmanthus fragrans is also included.

[0010] Furthermore, the composition includes the following components in weight percentage: 35% of roxburghii, 17% of dendrobium officinale, 2.8% of hovenia dulcis, 11.2% of kudzu root, 11.5% of cornus officinalis, 5.5% of chicory, 17% of hawthorn, and 0.1g of osmanthus.

[0011] Furthermore, the composition includes the following components in weight percentage: 35% of roxburghii, 17% of dendrobium officinale, 2.8% of hovenia dulcis, 11.2% of kudzu root, 11.5% of cornus officinalis, 5.5% of chicory, 3% of hawthorn, 5.5% of polygonatum, and 8.5% of sugar cane.

[0012] Among the above components, Rosa roxburghii is rich in effective ingredients such as Vc, polyphenols, SOD, etc.; Dendrobium officinale contains effective ingredients such as polysaccharides, flavonoids, and dendrobine; Hovenia dulcis contains effective ingredients such as flavonoids; Pueraria lobata mainly contains flavonoids; Cornus officinalis contains effective ingredients such as glycosides and flavonoids; Chicory contains calendula officinalis; Hawthorn contains Vc, dietary fiber and other ingredients; Polygonatum sibiricum is rich in polysaccharides, saponins, flavonoids and anthraquinone compounds; Sugarcane is mainly composed of sucrose and monosaccharides, and tastes sweet and delicious; Osmanthus contains volatile oils, flavonoids, phenolic compounds and other ingredients, with a prominent fragrance and overflowing aroma.

[0013] The present invention also provides a method for preparing the oral liquid for sobering up and protecting liver as described in the above technical scheme, comprising the following steps:

[0014] Step 1: Preparation of Solution A

[0015] The original solution of the roxburghii juice was concentrated 3 times and then adjusted to pH 4-5.5 with sodium bicarbonate to prepare solution A;

[0016] Step 2: Preparation of Solution B

[0017] (2.1) All raw materials except for the roxburghii are crushed into powder or cut into pieces or squeezed into juice according to the material characteristics, and the powdered and cut raw materials are added with pure water to immerse the materials by 2 to 3 cm, soaked for 30 minutes, and then 40 to 50 times the weight of water is added and boiled for 80 minutes until the material-liquid ratio reaches 1g:20-30mL, and after boiling, they are mixed and compounded in proportion to obtain a mixed solution;

[0018] (2.2) The mixed solution is concentrated under vacuum and centrifuged to remove impurities, and the supernatant is taken to obtain solution B.

[0019] Step 3: Packaging

[0020] Separate and package liquid A and liquid B to obtain an oral liquid for alcohol sobering up and protecting the liver, and mix them when using;

[0021] Step 4: Sterilization

[0022] Use circulating steam sterilization at a temperature of 100°C for 15 to 30 minutes.

[0023] Preferably, in step (2.1), Dendrobium officinale, Pueraria root, Hovenia dulcis, and Chicory are crushed into powder; sugarcane is squeezed into juice; and Cornus officinalis, Polygonatum sibiricum, and Hawthorn are cut into blocks of 1x1 cm.

[0024] Preferably, in step (2.2), the mixture is concentrated by vacuum for 4 to 6 times at 0.08 MPa, 30 rpm and 55° C., and then centrifuged at 5000 rpm for 5 min to remove impurities.

[0025] In view of the characteristics of the oral liquid, the present invention further provides a packaging bottle, comprising: a bottle body and a matching bottle cap, wherein the bottle body is divided into a liquid A storage area and a liquid B storage area by a closely connected partition plate 1 and a partition plate 2, wherein the partition plate 1 is provided with a through hole 1, and the partition plate 2 is provided with a through hole 2, and the positions of the through hole 1 and the through hole 2 are not opposite to each other;

[0026] A bevel gear 1 is arranged in the bottle cap, and a bevel gear 2 is arranged on the side wall of the bottle body of the liquid B storage area, and the bevel gear 1 is meshed with the bevel gear 2;

[0027] An L-shaped shaft is connected at the center of the second bevel gear, and the end of the L-shaped shaft is connected to a crank slider mechanism, and the crank slider mechanism is fixed at the center of the first partition.

[0028] It can be seen from the above technical scheme that, compared with the prior art, the present invention discloses an oral liquid with alcohol sobering and liver protecting functions, a preparation method thereof, and an oral liquid packaging bottle, which have the following beneficial effects:

[0029] The present invention selects natural food with the function of medicine and food as raw materials, contains rich active ingredients, such as flavonoids, polysaccharides, alkaloids, polyphenols, SOD, etc., is rich in nutrition, and has better taste, flavor, color, and tissue morphology. In addition, certain improvements are made on the packaging bottle, so that liquid A and liquid B are separated. When eating, the two liquids are opened and mixed and shaken for uniform consumption, which not only does not affect the functional components in the ingredients, but also allows consumers to feel the novelty of the packaging bottle and can arouse the interest of consumers, thereby improving the experience of consumers. As a natural health drink, this product is of great significance to the social development of many related enterprises. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the provided drawings without paying creative work.

[0031] Figure 1 This is the overall structural diagram of the packaging bottle of the present invention;

[0032] Figure 2-5 This is the experimental result diagram of the sample's hangover-relief effect;

[0033] Figure 6-7 The enzyme activity of flavonoid components in the sample to ALD and ACD;

[0034] In the figure, 1-bevel gear one, 2-bevel gear two, 3-bottle cap, 4-crank slider mechanism, 5-partition one, 6-partition two, 7-bottle body. DETAILED DESCRIPTION

[0035] The technical solution of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0036] Example 1

[0037] Liquid A is directly selected from the 3-fold concentrated roxburghii stock solution from the factory, and the pH is adjusted to between 4 and 5.5 with food sodium bicarbonate;

[0038] Preparation of Solution B:

[0039] (1) Material selection: Select the preferred materials that have medicinal effects and are edible, including Dendrobium officinale, Hovenia dulcis, Pueraria root, Cornus officinalis, Chicory, Polygonatum sibiricum, Crataegus pinnatifida and Sugarcane.

[0040] (2) Crushing: According to the characteristics of the materials themselves, Dendrobium officinale, Pueraria root, Hovenia dulcis, and Chicory were ground into powder using a crusher, sugarcane was squeezed into juice using a juicer, and Cornus officinalis, Polygonatum sibiricum, and Hawthorn were cut into 1x1 cm blocks;

[0041] (3) Soaking: Add pure water to the powder and block materials to cover the materials by 2 to 3 cm, and soak for 30 minutes to allow the materials to fully absorb water. The texture of the materials will become softer, shorten the cooking time, and the effective ingredients will be more easily dissolved in water;

[0042] (4) Decoction: After soaking, add 40 to 50 times the weight of water into a special container and boil it. Heat it with rapid fire. After boiling, simmer it with slow fire for 80 minutes. Decoction to a certain ratio of ingredients to water: 1g:30mL of Dendrobium officinale, 1g:20mL of Hovenia dulcis, 1g:20mL of Pueraria root, 1g:20mL of Cornus officinalis, 1g:20mL of Cichorium indica, 1g:20mL of Crataegus pinnatifida, 1g:20mL of Polygonatum sibiricum;

[0043] (5) Compounding: Through a large number of experimental proportions and tastings, and then through single-factor experiments to determine the formula combination, the formula ratio with the best taste, flavor, and color is obtained, that is, the following components in weight percentage: 35% of roxburghii (liquid A), 17% of dendrobium officinale, 2.8% of hovenia dulcis, 11.2% of kudzu root, 11.5% of cornus officinalis, 5.5% of chicory, 3% of hawthorn, 5.5% of polygonatum, and 8.5% of sugar cane; after mixing, a composite liquid is obtained;

[0044] (6) Concentration: The composite solution is concentrated by using a vacuum concentrator at 0.08 MPa, 30 rpm, and 55° C. to a concentration of 4 to 6 times;

[0045] (7) Centrifugation: Centrifuge at 5000 rpm for 5 min to remove impurities in the liquid;

[0046] (8) Packaging: Based on the body's alcohol intake of 8 ml / kg, the dosage of oral liquid is 15 ml. For an adult weighing 60 kg, 480 ml is required to achieve a better effect. This oral liquid is concentrated 3 to 6 times, so a 50 ml special bottle is selected for packaging;

[0047] (9) Sterilization: circulating steam sterilization, temperature 100°C, time 15-30 min;

[0048] Bottle structure Figure 1 As shown: comprising: a bottle body 7 and a matching bottle cap 3, wherein the bottle body 7 is divided into a liquid A storage area and a liquid B storage area by a closely connected partition 1 5 and a partition 2 6, wherein the partition 1 5 is provided with a through hole 1, and the partition 2 6 is provided with a through hole 2, and the positions of the through hole 1 and the through hole 2 are not opposite;

[0049] A bevel gear 1 is disposed inside the bottle cap 3, and a bevel gear 2 is disposed on the side wall of the bottle body 7 in the B liquid storage area, and the bevel gear 1 and the bevel gear 2 are meshed;

[0050] An L-shaped shaft is connected to the center of the bevel gear 2, and the end of the L-shaped shaft is connected to the crank slider mechanism 4. The end of the crank slider mechanism 4 is fixed to the center of the partition 1 5.

[0051] Principle of bottle packaging: when the bottle cap 3 is twisted, the bevel gear 1 rotates accordingly, thereby driving the bevel gear 2 2 meshing with it to rotate, and converting the rotation of the bottle cap 3 along the circumferential direction of the bottle body into the rotation of the bevel gear 2 2 along the axial direction of the bottle body. The bent part at the end of the L-shaped shaft connected to the bevel gear 2 2 serves as a crank, connected to a crank slider mechanism 4, and the slider of the crank slider mechanism 4 is fixed as a whole with the partition 1 5. When the rotation of the bevel gear 2 2 along the axial direction of the bottle body drives the crank to rotate, the partition 1 5 connected to the crank slider mechanism 4 moves upward along the axial direction of the bottle body, converting the rotation of the bevel gear 2 2 along the axial direction of the bottle body into the direct motion of the slider along the axial direction of the bottle body, thereby separating the partition 1 5 and the partition 2 6. The left half of the partition 1 5 has a through hole, and the right half of the partition 2 6 has a through hole. When the two partitions are in contact, the through holes complement each other, and liquid A is separated from liquid B. When the two partitions are separated, the through holes of the two partitions flow, and liquid A is mixed with liquid B.

[0052] Experimental example:

[0053] 1. Flavonoid content determination test

[0054] (1) To prepare a standard curve, 10 mg of rutin standard was completely dissolved in 70% (v / v) ethanol, the volume was fixed to 50 mL, and the solution was shaken to obtain a 0.2 mg / mL rutin standard solution.

[0055] (2) Take 0, 1.0, 2.0, 3.0, 4.0, 5.0, and 6.0 mL of rutin standard solution, and add 1 mL of 5% (m / v) NaNO2 solution, 1 mL of 10% (m / v) Al(NO3)3 solution, and 10 mL of 4% (m / v) NaOH solution in sequence. Each addition of reagents requires 6 minutes of reaction. Finally, add 70% (v / v) ethanol to 25 mL and let stand for 30 minutes. Use 70% (v / v) ethanol as the blank solution, measure the absorbance at 510 nm, and obtain the standard curve y=0.0121x+0.0016(R 2 =0.9994).

[0056] (3) Determination of flavonoids in samples: 1.0 mL of the sample solution prepared in Example 1 was taken, and the absorbance was measured at 510 nm according to the above steps. The flavonoid content of the sample (mgRE / 100 mL) was calculated according to the standard curve.

[0057] The results of the flavonoid content test are as follows (among the active ingredients of the oral solution, flavonoids mainly come from four raw materials: Rosa roxburghii, Dendrobium officinale, Pueraria lobata, and Hovenia dulcis):

[0058] Flavonoid content of four raw materials in standard 50ml oral solution

[0059] type Proportion (%) Volume after concentration (mL) Flavonoid content (mg) Rosa roxburghii 35 17.5 255.850 Dendrobium 17 8.5 3.840 Pueraria root 11.2 5.6 6.152 Zhizizi 2.8 1.4 8.311

[0060] In summary, the content of flavonoids in the oral solution is approximately 548.306 mg / 100 ml.

[0061] 2. Effect test:

[0062] An average of 15 male and female interns and graduate students aged 20-27 were selected as the subjects. Criteria: (1) Informed consent to the content and purpose of the experiment and voluntary participation in the experiment; (2) Healthy and without cardiovascular and cerebrovascular diseases.

[0063] Test method: drink 100mL of 53° liquor at one time, then drink the oral solution and rinse your mouth. After 5 minutes, blow into a special alcohol tester (produced by Shenzhen Zhaowei Technology Co., Ltd.) every 15 minutes to test, and immediately convert it into blood alcohol concentration. Record the data. Randomly select 6 people from 30 test personnel to calculate the average data as a group of data, and draw a blood alcohol concentration time change graph. The results are shown in the attached figure. Figure 2-5 As shown. (Sample 1 is a 3-fold concentrated oral liquid for alcohol detoxification and liver protection, and Sample 2 is a 4-fold concentrated oral liquid for alcohol detoxification and liver protection). Figure 1-5 They respectively represent the blood alcohol concentration data graph changes of the oral liquid packaging bottle and the test subjects after drinking alcohol but not drinking the oral liquid, and the blood alcohol concentration data change graph after drinking alcohol and drinking the oral liquid at the same time.

[0064] In summary, the test results show that the oral liquid has a certain effect of sobering up when the test subjects do not drink the oral liquid after drinking alcohol and when the test subjects drink the oral liquid after drinking alcohol at the same time.

[0065] 3. Enzyme Experiment

[0066] Alcohol dehydrogenase test: add 0.1 mL of alcohol dehydrogenase solution to 1 mL of sample solution, mix well and place in a 25°C incubation bath for 10 min. After the incubation, use the alcohol dehydrogenase activity detection kit to measure the enzyme activity;

[0067] 1. Preheat the spectrophotometer for 30 minutes, adjust the wavelength to 340nm, and set the value to zero with distilled water;

[0068] 2. Keep reagent 1 in a 25°C water bath for more than 15 minutes;

[0069] 3. Blank tube: Add 100μL distilled water, 40μL reagent 2, 760μL reagent 1 and 100μL reagent 3 to a 1mL quartz cuvette, mix quickly and measure the absorbance change at 340nm, record the absorbance at 15s and 75s, and record them as A1 and A2 respectively. AA blank tube = A1-A2. (Only 1 to 2 blank tubes are needed)

[0070] 4. Determination tube: Add 100μL supernatant, 40μL reagent 2, 760μL reagent 1 and 100μL reagent 3 in a 1mL quartz cuvette, mix quickly and measure the absorbance change at 340nm, record the absorbance at 15s and 75s, respectively, and record them as A3 and A4. △A determination tube = A3-A4.

[0071] 5. Activity unit definition: 1 μmol NADH oxidized per ml of sample per minute at 25°C is 1 enzyme activity unit.

[0072] ADH (U / mL) = [(ΔA test tube - ΔA blank tube) ÷ ε ÷ d * V total x 10 6 ]÷V

[0073] ÷T=1.61 * (ΔA determination tube-ΔA blank tube)

[0074] ε: NADH molar extinction coefficient, 6.22x10 3 L / mol / cm; d: 1mL quartz cuvette light path, 1cm; Vreaction: total volume of reaction system, 1000μL=0.001L; Vsample: volume of supernatant added to the reaction system, 100μL=0.1mL; T: reaction time, 1min.

[0075] Distilled water was used as control. Each experiment was repeated 2 to 3 times and the average value was taken.

[0076] Acetaldehyde dehydrogenase experiment: The enzyme activity was determined using an ACD activity detection kit, with distilled water as the control.

[0077] The enzyme activity of ALD in flavonoid components of sample 1 and sample 2 is as follows Figure 6 , the enzyme activity of ACD Figure 7 ,like Figure 6 and 7 As shown, this product has a good activation effect on alcohol dehydrogenase and acetaldehyde dehydrogenase. Alcohol dehydrogenase will decompose ethanol, and then the decomposed acetaldehyde will be decomposed into harmless acetic acid by acetaldehyde dehydrogenase. The main function of alcohol dehydrogenase and acetaldehyde dehydrogenase is to decompose alcohol. Therefore, this product has a certain function of sobering up.

[0078] In this specification, each embodiment is described in a progressive manner, and each embodiment focuses on the differences from other embodiments. The same or similar parts between the embodiments can be referred to each other. For the device disclosed in the embodiment, since it corresponds to the method disclosed in the embodiment, the description is relatively simple, and the relevant parts can be referred to the method part.

[0079] The above description of the disclosed embodiments enables one skilled in the art to implement or use the present invention. Various modifications to these embodiments will be apparent to one skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but rather to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. An oral liquid for sobering up and protecting the liver, characterized in that: The composition includes the following weight percentages: Rosa roxburghii 30%-45%, Dendrobium officinale 15%-25%, Hovenia dulcis 2%-5%, Pueraria lobata 5%-15%, Cornus officinalis 10%-15%, Chicory 5%-10%, Hawthorn 3%-20%.

2. The oral liquid for sobering up and protecting liver function according to claim 1, characterized in that: Calculated by weight percentage, the invention further comprises 5% to 10% of polygonatum and 8% to 15% of sugar cane.

3. The oral liquid for sobering up and protecting liver function according to claim 1, characterized in that: Calculated by weight percentage, the invention also includes 0.1 g to 0.5 g of osmanthus.

4. The oral liquid for sobering up and protecting liver function according to claim 3, characterized in that: The invention comprises the following components in percentage by weight: 35% of roxburghii, 17% of dendrobium officinale, 2.8% of hovenia dulcis, 11.2% of kudzu root, 11.5% of cornus officinalis, 5.5% of chicory, 17% of hawthorn, and 0.1g of osmanthus.

5. The oral liquid for sobering up and protecting liver function according to claim 2, characterized in that: The invention comprises the following components in percentage by weight: 35% of roxburghii, 17% of dendrobium officinale, 2.8% of hovenia dulcis, 11.2% of kudzu root, 11.5% of cornus officinalis, 5.5% of chicory, 3% of hawthorn, 5.5% of polygonatum and 8.5% of sugarcane.

6. A method for preparing the oral liquid for sobering up and protecting liver according to any one of claims 1 to 5, characterized in that: The following steps are involved: Step 1: Preparation of Solution A The original solution of the roxburghii juice was concentrated 3 times and then adjusted to pH 4-5.5 with sodium bicarbonate to obtain solution A; Step 2: Preparation of Solution B (2.1) All raw materials except for the roxburghii are crushed into powder or cut into pieces or squeezed into juice according to the material characteristics, and the powdered and cut raw materials are added with pure water to immerse the materials by 2 to 3 cm, soaked for 30 minutes, and then 40 to 50 times the weight of water is added and boiled for 80 minutes until the material-liquid ratio reaches 1g:20-30mL, and after boiling, they are mixed and compounded in proportion to obtain a mixed solution; (2.2) The mixed solution is concentrated under vacuum and centrifuged to remove impurities, and the supernatant is taken to obtain solution B. Step 3: Packaging Separate and package liquid A and liquid B to obtain an oral liquid for alcohol sobering up and protecting the liver, and mix them when using; Step 4: Sterilization Use circulating steam sterilization at a temperature of 100°C for 15 to 30 minutes.

7. The preparation method according to claim 6, characterized in that: In step (2.1), Dendrobium officinale, Pueraria root, Hovenia dulcis, and chicory are crushed into powder; sugarcane is squeezed into juice; and Cornus officinalis, Polygonatum sibiricum, and Hawthorn are cut into 1x1 cm blocks.

8. The preparation method according to claim 6, characterized in that: In step (2.2), the mixture was concentrated by vacuum at 0.08 MPa, 30 rpm and 55°C for 4 to 6 times, and then centrifuged at 5000 rpm for 5 min to remove impurities.

9. A packaging bottle for the oral liquid according to claims 1-5 or the oral liquid prepared by the method according to claims 6-8, characterized in that: include: A bottle body and a matching bottle cap, wherein the bottle body is divided into a liquid A storage area and a liquid B storage area by a closely connected partition plate 1 and a partition plate 2, the partition plate 1 is provided with a through hole 1, the partition plate 2 is provided with a through hole 2, and the positions of the through hole 1 and the through hole 2 are not opposite; A bevel gear 1 is arranged in the bottle cap, and a bevel gear 2 is arranged on the side wall of the bottle body of the liquid B storage area, and the bevel gear 1 is meshed with the bevel gear 2; An L-shaped shaft is connected at the center of the second bevel gear, and the end of the L-shaped shaft is connected to a crank slider mechanism, and the crank slider mechanism is fixed at the center of the first partition.