Composition with mild whitening effect and application thereof

Abstract

The invention discloses a composition with a mild whitening effect and application thereof, and belongs to the technical field of cosmetics. The composition is prepared from the following components in parts by weight: 0.1 to 40 parts of cistanche phenylethanoid glycoside extract and 0.1 to 40 parts of glabridin extract. Cistanche phenylethanoid glycoside and glabridin are mixed according to a certain ratio to form the mild whitening composition, and the two plant extracts are used in a combined manner to mutually enhance respective effects, so that a synergistic whitening effect is achieved. And the composition has the obvious advantage of being easily added into various types of formulas, and has good value and prospect in application to preparation of cosmetic products or food additives.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and in particular to a composition with mild whitening effect and application thereof. Background Art

[0002] In recent years, with the development of social economy and the change of people's aesthetic concepts, healthy and fair skin has become a skin condition pursued by many people, especially women, and the content and distribution of skin melanin is one of the main factors affecting skin color. Melanin is an amino acid-derived biological pigment and a polyphenol polymer. It can inhibit the damage of external stimuli such as ultraviolet rays and free radicals to skin cells. However, if it is over-synthesized and accumulated, it will not only be detrimental to the pursuit of beautiful skin color, but may also cause diseases such as chloasma, age spots, post-inflammatory hyperpigmentation (PIH) and even malignant melanoma. Therefore, ingredients that reduce melanin synthesis are often added to daily chemical products to prevent excessive accumulation of melanin and achieve whitening effects.

[0003] At present, the treatment of skin pigmentation mainly relies on inhibiting the activity of tyrosinase, which is the key enzyme in the formation of melanin. The latest research shows that skin pigmentation is closely related to the interaction between keratinocytes and melanocytes in the epidermis. The free radicals and inflammatory factors released by keratinocytes activate tyrosinase in melanocytes, increase the production and transport of melanin, and lead to pigmentation. Therefore, the treatment strategy needs to combine multiple methods such as inhibiting melanin production, anti-inflammatory and antioxidant. Although domestic and foreign scholars have studied a variety of natural ingredients from the perspective of inhibiting tyrosinase activity, the single method of inhibiting tyrosinase and high-concentration whitening ingredients may cause skin irritation and sensitivity, and long-term use may cause skin allergies and anti-blackening. Therefore, the development of a whitening product suitable for sensitive skin and long-term use without anti-blackening is an urgent problem to be solved in the current industry.

[0004] In view of this, the present invention is proposed. Summary of the invention

[0005] The first object of the present invention is to provide a composition with mild whitening effect, which comprises the following components in parts by weight: 0.1-40 parts of Cistanche phenylethanoid glycoside extract and 0.1-40 parts of glabridin extract.

[0006] In some preferred embodiments, the content of echinacoside in the Cistanche deserticola phenylethanoid glycoside extract is greater than or equal to 10%, and the content of glabridin in the glabridin extract is greater than or equal to 20%.

[0007] The second object of the present invention is to provide a composition with mild whitening effect for use in the preparation of cosmetic products or food additives.

[0008] The third object of the present invention is to provide a cosmetic with mild whitening effect, wherein the cosmetic comprises the above-mentioned composition with mild whitening effect.

[0009] The fourth object of the present invention is to provide a method for preparing cosmetics with mild whitening effect, comprising the following steps: mixing a moisturizer, a thickener, an emulsifier, an emollient and water at 30-70°C for homogeneity, then cooling to 25-45°C, adding a fragrance and a preservative and mixing with the Cistanche deserticola phenylethanoid glycoside and glabridin composition for homogeneity to obtain the cosmetics with mild whitening effect.

[0010] In some preferred embodiments, the moisturizer includes a combination of at least one of glycerin, 1,2-hexanediol, methylpropanediol, caprylhydroxamic acid, glyceryl caprylate, panthenol, β-glucan, tocopheryl acetate, butylene glycol, propylene glycol, sodium hyaluronate, dipropylene glycol, tremella polysaccharide, sodium PCA, allantoin or betaine.

[0011] In some preferred embodiments, the emulsifier includes a combination of at least one of cetyl alcohol, oleoyl polyoxyethylene glycerides, Tween 80, polyoxyethylene 35 castor oil, PEG-40 hydrogenated castor oil, polyglyceryl-6 distearate, polyglyceryl-3 beeswax acid, palmitic acid, stearic acid, sodium stearoyl glutamate, C14-22 alcohol, cetearyl olive oil ester, sorbitan olive oil ester, caprylic / capric triglyceride, bis-PEG / PPG-16 / 16PEG / PPG-16 / 16 polydimethylsiloxane, behenyl alcohol, inulin lauryl carbamate, glyceryl monostearate, coconut glucoside, PEG-10 polydimethylsiloxane, polysorbate -20, glyceryl stearate, PEG-100 stearate, steareth -21 sorbitan stearate, cetyl phosphate potassium or C14-22 alcohol / C12-20 alkyl glucoside.

[0012] In some preferred embodiments, the emollient includes a combination of at least one of triethylhexanoin, C12-20 alkyl glucoside, C10-18 fatty acid triglycerides, macadamia seed oil, avocado tree butter, jojoba seed oil, isododecane, pentaerythrityl tetraethylhexanoate, jojoba esters, helianthus annuus seed wax, polyglyceryl-3, vitex acutissima flower wax, tocopherol (vitamin E), dimethiconol, cetyl alcohol, squalane, neotol myristate, shea butter, isohexadecane, dimethicone, castor oil maleate, cyclo-5 dimethicone, cetearyl alcohol, avocado oil, fenugreek oil, candelilla wax, isononyl isononanoate, isopropyl palmitate, dimethicone or PEG-6 caprylic / capric triglyceride.

[0013] In some preferred embodiments, the thickener includes a combination of at least one of xanthan gum, guar gum, hydrogenated lecithin, microcrystalline cellulose, hydroxyethyl cellulose, and ammonium acryloyldimethyltaurate / VP copolymer.

[0014] The fifth object of the present invention is to provide a method for preparing lipid vesicles of a composition with mild whitening effect, the steps comprising: weighing a prescribed amount of non-ionic surfactant and cholesterol into a round-bottom flask, adding 5-15 mL of dichloromethane for ultrasonic dissolution, reducing pressure and rotary evaporation to remove the organic solvent to obtain a translucent film, then adding a solution of the Cistanche deserticola phenylethanoid glycoside and glabridin composition with mild whitening effect, hydrating at 30-80° C. for 1-1.5 hours to form a uniform milky yellow suspension, and then ultrasonicating in a water bath at 30-80° C. for 15-60 minutes.

[0015] The present invention has the following beneficial effects:

[0016] 1. The present invention mixes Cistanche deserticola phenylethanoid glycoside and glabridin extract in a certain ratio as a mild whitening composition, which plays a synergistic role at multiple levels: first, inhibiting the activity of cell tyrosinase, reducing the generation of melanin in the skin aging process from the root, and achieving a whitening effect; second, inhibiting the excessive production of skin free radicals, and having a soothing and repairing effect on the skin; third, reducing the release of inflammatory factors produced by the skin, reducing the occurrence of allergies, and also reducing the deposition of inflammatory pigments. Multiple pathways can improve skin brightness and reduce spots.

[0017] 2. The mild whitening composition of the present invention was combined with Cistanche phenylethanoid glycoside and glabridin extract to carry out many experiments. It was found that both of them had good whitening effects when used alone or in combination, and the effect of using the two together was more significant than that of using them alone. They enhanced their respective effects and achieved a synergistic whitening effect.

[0018] 3. The present invention uses two extracts in the mild whitening composition in combination, which, on the one hand, improves the problem of insufficient whitening effect of glabridin extract due to low solubility; secondly, it is easy to be mixed with other ingredients into cosmetics, and has the obvious advantage of being easy to add to various types of formulas, so it has great value and prospects for application in cosmetics development. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required for use in the embodiments are briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present invention and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without creative work.

[0020] Figure 1 The inhibitory effect of the compound of Cistanche deserticola phenylethanoid glycoside extract and glabridin extract on tyrosinase;

[0021] Figure 2 The scavenging rate of DPPH free radicals by the compound of Cistanche deserticola phenylethanoid glycoside extract and glabridin extract;

[0022] Figure 3 The scavenging rate of ABTS free radicals by the mixture of Cistanche deserticola phenylethanoid glycoside extract and glabridin extract. DETAILED DESCRIPTION

[0023] In order to make the purpose, technical scheme and advantages of the embodiments of the present invention clearer, the technical scheme in the embodiments of the present invention will be described clearly and completely below. If the specific conditions are not specified in the embodiments, they are carried out according to conventional conditions or conditions recommended by the manufacturer. If the manufacturer of the reagents or instruments used is not specified, they are all conventional products that can be purchased commercially.

[0024] The following is a detailed description of a composition with mild whitening effect and its application proposed in the present application.

[0025] The invention provides a composition with mild whitening effect, which comprises the following components in parts by weight: 0.1-40 parts of Cistanche deserticola phenylethanoid glycoside extract and 0.1-40 parts of glabridin extract.

[0026] The phenylethanoid glycoside extract of Cistanche deserticola can inhibit the activity of tyrosinase and the production of melanin in human epidermal melanocytes, and has antioxidant and anti-inflammatory effects, can remove free radicals and reduce pigmentation caused by inflammation, and achieve a whitening effect. The glabridin extract not only acts on a single pathway, but can cover multiple pathways such as soothing, inhibiting tyrosinase activity, and anti-oxidation, achieving a mild whitening effect from multiple aspects.

[0027] In some preferred embodiments, the content of echinacoside in the Cistanche deserticola phenylethanoid glycoside extract is greater than or equal to 10%, and the content of glabridin in the glabridin extract is greater than or equal to 20%.

[0028] Among them, echinacoside is the main active ingredient in the extract of Cistanche phenylethanoid glycosides. The higher the content, the better the whitening effect. When the echinacoside content in the extract of Cistanche phenylethanoid glycosides is greater than or equal to 10%, the whitening effect it can produce is the best. Glabridin is known as the "whitening gold" and has a significant whitening effect. The increase in the content of glabridin in the extract has a significant positive effect on the mild whitening effect.

[0029] The present invention also provides an application of the composition with mild whitening effect in the preparation of cosmetic products or food additives.

[0030] Secondly, the present invention provides a cosmetic with mild whitening effect, which comprises the above-mentioned composition with mild whitening effect.

[0031] The types of cosmetics include cleansers, toners, lotions, facial masks, creams, essences, primers, liquid foundations or cream foundations.

[0032] The present invention also provides a method for preparing the above-mentioned cosmetics with mild whitening effect, comprising the following steps: mixing a moisturizer, a thickener, an emulsifier, an emollient and water at 30-80°C for homogeneity, then cooling to 25-45°C, adding a fragrance and a preservative and mixing with the Cistanche deserticola phenylethanoid glycoside and glabridin composition for homogeneity to obtain the cosmetics with mild whitening effect.

[0033] In some preferred embodiments, the moisturizer includes a combination of at least one of glycerin, 1,2-hexanediol, methylpropanediol, caprylhydroxamic acid, glyceryl caprylate, panthenol, β-glucan, tocopheryl acetate, butylene glycol, propylene glycol, sodium hyaluronate, dipropylene glycol, tremella polysaccharide, sodium PCA, allantoin or betaine.

[0034] Among them, the above-mentioned moisturizers have the characteristics of high-efficiency moisturizing and multi-effects, and can be widely used in a variety of cosmetics. The above-mentioned moisturizer types are selected because these ingredients are mild to the skin and will not cause skin irritation.

[0035] In some preferred embodiments, the emulsifier includes a combination of at least one of cetyl alcohol, oleoyl polyoxyethylene glycerides, Tween 80, polyoxyethylene 35 castor oil, PEG-40 hydrogenated castor oil, polyglyceryl-6 distearate, polyglyceryl-3 beeswax acid, palmitic acid, stearic acid, sodium stearoyl glutamate, C14-22 alcohol, cetearyl olive oil ester, sorbitan olive oil ester, caprylic / capric triglyceride, bis-PEG / PPG-16 / 16PEG / PPG-16 / 16 polydimethylsiloxane, behenyl alcohol, inulin lauryl carbamate, glyceryl monostearate, coconut glucoside, PEG-10 polydimethylsiloxane, polysorbate -20, glyceryl stearate, PEG-100 stearate, steareth -21 sorbitan stearate, cetyl phosphate potassium or C14-22 alcohol / C12-20 alkyl glucoside.

[0036] Among them, the above-mentioned emulsifiers are relatively stable in acidic and alkaline environments, are not easily hydrolyzed, and are insensitive to electrolytes. They can be compounded with other emulsifiers and have good synergistic effects. In addition, these emulsifiers are all derived from plants, have good safety, and are mild and non-irritating to the skin.

[0037] In some preferred embodiments, the emollient includes a combination of at least one of triethylhexanoin, C12-20 alkyl glucoside, C10-18 fatty acid triglycerides, macadamia seed oil, avocado tree butter, jojoba seed oil, isododecane, pentaerythrityl tetraethylhexanoate, jojoba esters, helianthus annuus seed wax, polyglyceryl-3, vitex acutissima flower wax, tocopherol (vitamin E), dimethiconol, cetyl alcohol, squalane, neotol myristate, shea butter, isohexadecane, dimethicone, castor oil maleate, cyclo-5 dimethicone, cetearyl alcohol, avocado oil, fenugreek oil, candelilla wax, isononyl isononanoate, isopropyl palmitate, dimethicone or PEG-6 caprylic / capric triglyceride.

[0038] Among them, the ingredients selected for the emollients all have unique physical and chemical properties, providing moisture and protection for the skin while ensuring the stability of the product.

[0039] In some preferred embodiments, the thickener includes a combination of at least one of xanthan gum, guar gum, hydrogenated lecithin, microcrystalline cellulose, hydroxyethyl cellulose, and ammonium acryloyldimethyltaurate / VP copolymer.

[0040] Among them, the above-selected thickeners can achieve the ideal thickening effect at a relatively low addition amount, while also providing a good feel and product stability. Therefore, they are widely used in the cosmetics, food, and pharmaceutical industries to improve the physical properties of the products.

[0041] Finally, the present invention provides a method for preparing lipid vesicles of a composition with mild whitening effect, the steps comprising: weighing a prescribed amount of non-ionic surfactant and cholesterol into a round-bottom flask, adding 5-15 mL of dichloromethane for ultrasonic dissolution, reducing pressure and rotary evaporation to remove the organic solvent to obtain a translucent film, then adding a solution of the Cistanche deserticola phenylethanoid glycoside and glabridin composition with mild whitening effect, hydrating at 30-80° C. for 1-1.5 hours to form a uniform milky yellow suspension, and then ultrasonicating in a water bath at 30-80° C. for 15-60 minutes.

[0042] Among them, lipid vesicles can be used to prepare lotions, emulsions, facial masks, creams or essences, giving them a mild whitening effect.

[0043] The features and performance of the present invention are further described in detail below in conjunction with the embodiments.

[0044] The Cistanche phenylethanoid glycoside extract and glabridin extract used in the present invention are both selected from Shaanxi Tianxingjian Biochemical Technology Co., Ltd., including the Cistanche phenylethanoid glycoside extract (echinacoside content ≥ 10%) and the glabridin extract (content ≥ 20%).

[0045] Example 1

[0046] This embodiment provides a combination with mild whitening effect, which is composed of the following components in parts by weight: 40 parts of Cistanche phenylethanoid glycoside extract and 1 part of glabridin extract.

[0047] Example 2

[0048] This embodiment provides a combination with mild whitening effect, which is composed of the following components in parts by weight: 20 parts of Cistanche phenylethanoid glycoside extract and 1 part of glabridin extract.

[0049] Example 3

[0050] This embodiment provides a combination with mild whitening effect, which is composed of the following components in parts by weight: 10 parts of Cistanche phenylethanoid glycoside extract and 1 part of glabridin extract.

[0051] Example 4

[0052] This embodiment provides a combination with mild whitening effect, which is composed of the following components in parts by weight: 5 parts of Cistanche phenylethanoid glycoside extract and 1 part of glabridin extract.

[0053] Comparative Example 1

[0054] This comparative example provides a combination with mild whitening effect, which is composed of the following components in parts by weight: 1 part of Cistanche deserticola phenylethanol glycoside extract.

[0055] Comparative Example 2

[0056] This comparative example provides a combination with mild whitening effect, which is composed of the following components in parts by weight: 1 part of glabridin extract.

[0057] Comparative Example 3

[0058] This comparative example provides a combination with mild whitening effect, which is composed of the following components in parts by weight: 1 part of Cistanche phenylethanoid glycoside extract and 1 part of glabridin extract.

[0059] Comparative Example 4

[0060] This comparative example provides a combination with mild whitening effect, which is composed of the following components in parts by weight: 1 part of Cistanche phenylethanoid glycoside extract and 5 parts of glabridin extract.

[0061] Comparative Example 5

[0062] This comparative example provides a combination with mild whitening effect, which is composed of the following components in parts by weight: 1 part of Cistanche phenylethanoid glycoside extract and 10 parts of glabridin extract.

[0063] Comparative Example 6

[0064] This comparative example provides a combination with mild whitening effect, which is composed of the following components in parts by weight: 1 part of Cistanche phenylethanoid glycoside extract and 20 parts of glabridin extract.

[0065] Comparative Example 7

[0066] This comparative example provides a combination with mild whitening effect, which is composed of the following components in parts by weight: 1 part of Cistanche phenylethanoid glycoside extract and 40 parts of glabridin extract.

[0067] Test example

[0068] The compositions of Examples 1-4 and Comparative Examples 1-7 were selected to study the effects of the compositions on tyrosinase activity, anti-oxidation and anti-inflammatory aspects.

[0069] Test 1: Inhibition of tyrosinase activity

[0070] The whitening effect of the composition was evaluated with the tyrosinase inhibition rate as the evaluation index: the experiment was divided into two groups: the experimental group and the control group, using a 96-well plate as the carrier. The experimental group was added with 50 μL of samples of different concentrations, and the control group was added with 50 μL of Ab solution. After incubation at 37°C for 10 minutes, 50 μL of tyrosinase was added to the experimental group and the control group, mixed evenly, and the absorbance (A) value was measured at a wavelength of 475 nm after incubation at 37°C for 5 minutes.

[0071] The results are as follows Figure 1 As shown in the figure, at a mass concentration of 0.4 mg / mL, the inhibition rate of the compound with a mass ratio of PhGs to Gla of 5:1 and 1:1 on tyrosinase was higher than that of the single component at the same mass concentration, and the inhibition rate of the mass ratio of 1:1 was equivalent to the positive control Arb. The CI of the compound ratio of 1:5-1:40 was > 1, while the CI of the compound ratio of 40:1-1:1 was < 1, indicating that PhGs and Gla had a good synergistic effect at a mass ratio of 40:1-1:1.

[0072] Test 2: DPPH free radical scavenging ability test

[0073] The whitening effect of the composition was evaluated using the DPPH free radical scavenging ability as the evaluation index: First, accurately weigh DPPH, use anhydrous ethanol to prepare a 0.2mM DPPH solution, and store it in the dark. The experiment was divided into two groups: an experimental group and a control group. 50μL of samples of different concentrations were added to the experimental group, and 50μL of Vc solution was added to the control group. After incubation at 37°C for 10min, 3ml of DPPH solution was added to the reaction group and the blank group, mixed evenly, and the absorbance (A) value was measured at a wavelength of 517nm after standing at 37°C for 30min. Finally, the antioxidant capacity of the sample was calculated based on the change in absorbance to obtain the final DPPH free radical scavenging rate.

[0074] The results are as follows Figure 2 As shown in the figure, at a mass concentration of 0.4 mg / mL, the scavenging rate of the compound with a mass ratio of PhGs to Gla of 40:1-1:1 was higher than that of the single component with the same mass concentration, which was equivalent to the positive control Vc. The CI of the compound ratio of 1:5-1:40 was greater than 1, which showed an antagonistic effect, and the CI of the compound ratio of 40:1-1:1 was less than 1, and the DPPH radical scavenging rate of the five compounds could reach 85% or more, which showed good DPPH radical scavenging ability.

[0075] Test 2: ABTS free radical scavenging ability test

[0076] The whitening effect of the composition was evaluated with the ABTS free radical scavenging ability as the evaluation index: first, accurately weigh ABTS, mix ABTS with 0.1M phosphate buffer (pH7.4) at a ratio of 1:1, add an appropriate amount of H2O2, and place it at room temperature for 30 minutes until its absorbance (734nm) stabilizes at 0.7-0.8. The experiment was divided into two groups: experimental group and control group. 50μL samples of different concentrations were added to the experimental group, and 50μL Vc solution was added to the control group. After incubation at 37°C for 10min, 3ml of the prepared solution was added to the reaction group and the blank group, mixed evenly, and the absorbance (A) value was measured at a wavelength of 734nm after standing at 37°C for 30min. Finally, the antioxidant capacity of the sample was calculated based on the change in absorbance, and the final ABTS free radical scavenging rate was obtained.

[0077] The results are as follows Figure 3 As shown: When the mass concentration is 0.4 mg / mL, the scavenging rate of the compound with a mass ratio of PhGs to Gla of 40:1-1:1 on ABTS free radicals is higher than that of the single component with the same mass concentration, which is equivalent to the positive control Vc. From the CI value, it can be seen that the CI of the compound ratio of 1:5-1:40 is greater than 1, which has an antagonistic effect, and the CI of the compound ratio of 40:1-1:1 is less than 1, which has a good synergistic effect.

[0078] In summary, in the implementation plan of this scheme, the mixing ratio of Cistanche phenylethanol glycoside extract and glabridin extract is adjusted. After studying their inhibition on tyrosinase activity and scavenging ability on DPPH and ABTS free radicals, it is found that when the mixing ratio of Cistanche phenylethanol glycoside extract and glabridin extract is 1:1-10:1, it has relatively good inhibitory effect and synergistic effect in inhibiting tyrosinase activity and anti-oxidation, and can have better mild whitening effect.

[0079] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A composition with mild whitening effect, characterized in that: The invention comprises the following components in parts by weight: 0.1-40 parts of Cistanche deserticola phenylethanoid glycoside extract and 0.1-40 parts of glabridin extract.

2. A composition with mild whitening effect according to claim 1, characterized in that: The content of echinacoside in the Cistanche deserticola phenylethanoid glycoside extract is greater than or equal to 10%, and the content of glabridin in the glabridin extract is greater than or equal to 20%.

3. Use of the composition with mild whitening effect according to claim 1 or 2 in the preparation of cosmetic products or food additives.

4. A cosmetic with mild whitening effect, characterized in that: The cosmetic comprises a composition with mild whitening effect as claimed in claim 1 or 2.

5. The method for preparing a cosmetic with mild whitening effect according to claim 4, characterized in that: The following steps are involved: The moisturizer, thickener, emulsifier, emollient and water are mixed and homogenized at 30-70°C, and then the temperature is lowered to 25-45°C, and then aromatics and preservatives are added and mixed with the combination of Cistanche deserticola phenylethanoid glycoside and glabridin with mild whitening effect to obtain the cosmetics with mild whitening effect.

6. A cosmetic with mild whitening effect according to claim 5, characterized in that: The moisturizing agent includes a combination of at least one of glycerin, 1,2-hexanediol, methylpropanediol, caprylhydroxamic acid, glyceryl caprylate, panthenol, β-glucan, tocopheryl acetate, butylene glycol, propylene glycol, sodium hyaluronate, dipropylene glycol, tremella polysaccharide PCA sodium, allantoin or betaine.

7. A cosmetic with mild whitening effect according to claim 5, characterized in that: The emulsifier includes a combination of at least one of cetyl alcohol, oleoyl polyoxyl glycerides, Tween 80, polyoxyl 35 castor oil, PEG-40 hydrogenated castor oil, polyglyceryl-6 distearate, polyglyceryl-3 beeswax acid, palmitic acid, stearic acid, sodium stearoyl glutamate, C14-22 alcohol, cetearyl olivate, sorbitan olivate, caprylic / capric triglyceride, bis-PEG / PPG-16 / 16PEG / PPG-16 / 16 dimethicone, behenyl alcohol, inulin lauryl carbamate, glyceryl monostearate, cocoyl glucoside, PEG-10 dimethicone, polysorbate-20, glyceryl stearate, PEG-100 stearate, steareth-21 sorbitan stearate, potassium cetyl phosphate, or C14-22 alcohol / C12-20 alkyl glucoside.

8. The cosmetic with mild whitening effect according to claim 5, characterized in that: The emollient includes a combination of at least one of triethylhexanoin, C12-20 alkyl glucoside, C10-18 fatty acid triglycerides, macadamia seed oil, avocado tree butter, jojoba seed oil, isododecane, pentaerythrityl tetraethylhexanoate, jojoba esters, helianthus annuus seed wax, polyglyceryl-3, vitex acutissima flower wax, tocopherol (vitamin E), dimethiconol, cetyl alcohol, squalane, neotol myristate, shea butter, isohexadecane, dimethicone, castor oil maleate, cyclo-5 dimethicone, cetearyl alcohol, avocado oil, fenugreek oil, candelilla wax, isononyl isononanoate, isopropyl palmitate, dimethicone or PEG-6 caprylic / capric triglyceride.

9. A cosmetic with mild whitening effect according to claim 5, characterized in that: The thickener includes a combination of at least one of xanthan gum, guar gum, hydrogenated lecithin, microcrystalline cellulose, hydroxyethyl cellulose, or ammonium acryloyldimethyltaurate / VP copolymer.

10. The method for preparing lipid vesicles of a composition having mild whitening effect according to claim 1, characterized in that the steps include: The nonionic surfactant and cholesterol in the prescribed amount are weighed into a round-bottom flask, 5-20 mL of dichloromethane is added for ultrasonic dissolution, and the organic solvent is removed by rotary evaporation under reduced pressure to obtain a translucent film, and then a solution of the combination of Cistanche deserticola phenylethanoid glycoside and glabridin with mild whitening effect is added, hydrated at 30-80° C. for 1-1.5 hours to form a uniform milky yellow suspension, and then ultrasonicated in a water bath at 30-80° C. for 15-60 minutes.

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