Formula and preparation method of scalp cleaning liquid with effects of controlling oil and removing dandruff

Abstract

The invention belongs to the field of cosmetics, and particularly relates to a scalp cleaning liquid formula with oil control and dandruff removal effects and a preparation method of the scalp cleaning liquid formula. The scalp cleaning liquid with the effects of controlling oil and removing dandruff is prepared from the following components in parts by mass: 0.1 to 0.2 part of juniper berry essential oil, 0.1 to 0.15 part of menthol, 42.0 to 61.0 part of a surfactant, 0.05 to 0.15 part of citric acid, 0.5 to 1.0 part of azelaic acid, 0.15 to 0.25 part of oat alkaloid, 0.08 to 0.1 part of glycyrrhizic acid, 36.72 to 54.85 parts of water and 1.05 to 1.75 parts of an auxiliary agent. The scalp cleaning liquid provided by the invention has safe and non-irritant components, can effectively control oil and remove dandruff on scalp, and can create a good scalp environment by controlling oil, inhibiting bacteria, relieving and diminishing inflammation and promoting metabolism of old cutin, thereby solving the problems that a traditional oil-control and dandruff-removing product can only take effect in a short time, and scalp grease, flora and metabolic balance are damaged after the product is used for a long time.

Description

Technical Field

[0001] The invention belongs to the field of cosmetics, and in particular relates to a formula of a scalp cleansing liquid with oil-controlling and dandruff-removing effects and a preparation method thereof. Background Art

[0002] A healthy scalp ecological environment is maintained by the balance of oil, flora, and metabolism. If these balances are damaged, dandruff and oily scalp problems will occur. Excessive secretion of scalp oil will make the scalp greasy, leading to the overgrowth of harmful bacteria. Overgrowth of harmful bacteria destroys the balance of scalp flora and causes itchy scalp. At the same time, excessive growth of harmful bacteria such as Malassezia in the scalp flora will stimulate the rapid metabolism and shedding of the scalp stratum corneum, forming dandruff. The balance of scalp oil, flora, and metabolism are closely linked to form a healthy scalp chain. Problems in one link will lead to a vicious cycle of scalp problems such as dandruff and oily scalp. Therefore, to effectively solve scalp problems, it is necessary to maintain the three major balances of the scalp.

[0003] Excessive secretion of scalp oil glands is usually caused by excessive androgen, especially dihydrotestosterone (hereinafter referred to as DHT), which plays an important role in the differentiation, proliferation and oil secretion of sebaceous gland cells. Human sebaceous gland cells contain 5α-reductase, which can convert testosterone into more active DHT. Therefore, inhibiting the activity of 5α-reductase can inhibit the production of DHT and block the combination of testosterone and sebaceous gland cells, ultimately inhibiting the excessive oil secretion of sebaceous glands. The oil secretion of scalp skin is also closely related to the number of microorganisms in the sebaceous glands. Propionibacterium acnes proliferates abnormally in the excessive oily scalp environment, stimulating excessive keratinization of the scalp and causing dandruff. At the same time, Staphylococcus epidermidis, Propionibacterium granulosum, and Malassezia work together to increase the activity of SZ95 sebaceous gland cells and promote sebum secretion. Abnormal scalp oil secretion stimulates the proliferation of harmful bacteria such as Malassezia, which stimulates the production of dandruff; abnormal proliferation of harmful bacteria such as Malassezia increases the activity of SZ95 sebaceous gland cells, promotes the secretion of sebum, and provides a good environment for the abnormal proliferation of harmful bacteria such as Malassezia. The above vicious closed loop makes it impossible to effectively improve oily scalp and dandruff. Based on the above reasons for scalp oil secretion and dandruff production, inhibiting 5α-reductase activity, effectively controlling oil, inhibiting the abnormal proliferation of harmful bacteria, soothing the scalp, and reducing inflammation and itching have become the inevitable choice of oil control and dandruff products.

[0004] Traditional oil-control and anti-dandruff products mainly achieve the purpose of oil-control and anti-dandruff by adding antifungal drugs such as ketoconazole, climbazole, zinc pyrithione (ZPT), etc. to inhibit the growth of scalp microorganisms and reduce the production of dandruff. Although the above anti-dandruff methods can have a certain anti-dandruff effect in a short period of time, excessive antibacterial and sterilization also affect the survival of beneficial scalp bacteria, so that after repeated use of this type of product, itching of the head is aggravated and dandruff is more serious. Therefore, a long-lasting oil-control and anti-dandruff product with safe ingredients and mild effects has become a market demand. Summary of the invention

[0005] The technical problem to be solved by the present invention is to provide a long-lasting oil control and anti-dandruff combination with safe ingredients and mild effects, which can control oil, inhibit bacteria, reduce inflammation, soothe, and create a good scalp environment, thereby solving the problem that traditional oil control and anti-dandruff products can only play a short-term oil control and anti-dandruff function, while long-term use will destroy the balance of scalp oil, flora, and metabolism.

[0006] In order to achieve the above-mentioned object, the first aspect of the present invention provides a scalp cleansing liquid with oil control and dandruff removal effects, which comprises the following components in parts by mass:

[0007] 0.1-0.2 parts of juniper berry essential oil, 0.1-0.15 parts of menthol, 42.0-61.0 parts of surfactants, 0.05-0.15 parts of citric acid, 0.5-1.0 parts of azelaic acid, 0.15-0.25 parts of oat alkaloids, 0.08-0.1 parts of glycyrrhetinic acid, 36.72-54.85 parts of water, and 1.05-1.75 parts of auxiliary agents.

[0008] The glycyrrhetinic acid used in the present invention is a pentacyclic triterpene having multiple biological activities, and having functions such as anti-oxidation and antibacterial.

[0009] The azelaic acid used in the present invention has the advantages of being safe and less irritating. It can competitively inhibit the enzyme process that produces DHT, and has both bactericidal, antibacterial and anti-inflammatory effects. It can directly inhibit and kill bacteria on the skin surface and in hair follicles, and eliminate pathogens.

[0010] The oat alkaloids used in the present invention are excellent skin protectants, have strong skin anti-inflammatory and antipruritic activities, and have obvious antioxidant and anti-allergic properties. They can relieve scalp inflammation and alleviate the symptoms of dandruff.

[0011] The juniper berry essential oil used in the present invention enhances the anti-allergic and anti-oxidative capabilities of human skin and delays skin aging. It contains multiple active ingredients such as cadinone and cadinol, which can inhibit the reproduction of fungi and bacteria on the skin surface. The rich vitamins, eugenol, etc. in the juniper berry essential oil can promote blood circulation and nourish hair follicles. It contains ingredients such as glyceride and vitamin E, which has the effect of moisturizing and keeping the moisture of scalp skin and improves dry skin.

[0012] The menthol used in the present invention has a cooling and soothing effect, can effectively alleviate the uncomfortable symptoms such as itchy head, and improve the user experience. Menthol has an astringent effect, and as an astringent, it has a certain alleviating effect on oily scalp and scalp acne.

[0013] The citric acid used in the present invention can promote the renewal of scalp cuticle, soften the detached and aged cuticle, improve the permeability of scalp hair follicles, and reduce the generation of dandruff. As an acid-base regulator, citric acid can adjust the pH value of the product system to adapt to the pH value of the scalp, thereby protecting the acidic protective film of the skin, maintaining the normal physiological function of the skin, and further reducing the irritation of the present invention to the skin. The citric acid selected in the present invention can play a good auxiliary role in the formula, helping other active ingredients to better play their roles and improving the efficiency of the product in maintaining the healthy state of the scalp.

[0014] The present invention starts from the three angles of oil control, antibacterial and maintaining metabolic balance, and can play a significant role in oil control and dandruff removal, and protect the healthy environment of the scalp.

[0015] First, in terms of oil balance, the combination of azelaic acid and glycyrrhetinic acid in the present invention can achieve a synergistic effect and further inhibit excessive oil secretion of the scalp. Glycyrrhetinic acid can help inhibit excessive oil secretion of the scalp by inhibiting the activity of 5α-reductase. On this basis, azelaic acid inhibits the downstream enzyme process of producing DHT. The two synergistically enhance the effect of fully inhibiting excessive oil secretion of the scalp.

[0016] Secondly, from the perspective of antibacterial and maintaining the balance of flora, the present invention adopts glycyrrhetinic acid, azelaic acid and juniper berry essential oil, and the concentration is suitable, which can effectively inhibit the reproduction of harmful flora of the scalp without affecting the reproduction of beneficial bacteria too much, thereby achieving the effect of inhibiting excessive oil production of the scalp and abnormal proliferation of keratin, and then maintaining the health of the scalp environment. Glycyrrhetinic acid can reduce the expression of virulence genes of bacteria, disrupt the metabolic process of bacteria, and destroy the morphological structure of cells, while azelaic acid can directly inhibit and kill bacteria on the surface of the skin and in the hair follicles, eliminate pathogens, and the antibacterial components in juniper berry essential oil inhibit the survival ability of microorganisms such as bacteria by destroying the cell membrane of bacteria. The three are reasonably matched, which can better alleviate the bacterial and fungal ecological imbalance when seborrheic dermatitis occurs on the scalp, and inhibit the growth and reproduction of harmful bacteria on the scalp surface. At the same time, compared with acids such as salicylic acid and mandelic acid, azelaic acid has high safety, low irritation and better antibacterial effect. Finally, the citric acid used in the present invention has certain antibacterial ability, and can assist glycyrrhizin, azelaic acid and juniper berry essential oil to further inhibit the growth and reproduction of harmful microorganisms such as Malassezia on the scalp surface, thereby helping to maintain a healthy scalp.

[0017] It is also worth noting that the targets of most anti-dandruff products are the sebaceous glands under the skin, which requires consideration of the transmission and penetration efficiency of the active ingredients in the product. The 0.5-1.0% mass percentage of azelaic acid in the oil-control and anti-dandruff cleansing liquid of the present invention can deliver sufficient concentration to the target points, and can effectively kill bacteria and anti-inflammatories together with glycyrrhetinic acid, cadinone in juniper berry essential oil, cadinol, etc.

[0018] Finally, in terms of metabolic balance, the present invention first uses oat alkaloids and glycyrrhetinic acid to synergistically inhibit inflammation of the scalp, and inhibits the abnormal proliferation of scalp keratin by inhibiting inflammation, thereby maintaining the health of the scalp. Secondly, the present invention can also effectively soften and peel off abnormally proliferating dandruff through the dual acid compound of citric acid and azelaic acid. Finally, a mild surfactant compound system is used to further promote the removal of old keratin from the scalp and help the scalp establish a healthy skin environment.

[0019] Preferably, the surfactant comprises the following components, measured in parts by mass: 35.0 to 45.0 parts of cocamidopropyl betaine, 3.0 to 7.0 parts of sodium methyl cocoyl taurate, 1.0 to 2.0 parts of cocoyl glucoside, and 3.0 to 7.0 parts of disodium cocoamphodiacetate.

[0020] The present invention adopts cocamidopropyl betaine, sodium methyl cocoyl taurate, cocoyl glucoside, and disodium cocoamphodiacetate to form a surfactant compound system with high biocompatibility, the advantages of being easily soluble in water, being stable to acid and alkali, and having rich foam. Cocamidopropyl betaine is a zwitterionic surfactant; cocoyl glucoside is a nonionic surfactant; sodium methyl cocoyl taurate is an amino acid surfactant with mild properties; and disodium cocoamphodiacetate is a zwitterionic surfactant. The surfactant compound system formed by the reasonable combination of these four surfactants, cocamidopropyl betaine and disodium cocoamphodiacetate can make the surfactant compound system have excellent stability under acidic and alkaline conditions, and is insensitive to electrolytes. Cocoyl glucoside can be well compatible with the other three surfactants, reduce the irritation of the surfactant compound system, and enable it to selectively remove harmful alcohols on the skin surface. Finally, sodium methyl cocoyl taurate is added to make the surfactant system have rich foam, mild and stable cleaning power, and can remove excess oil on the scalp surface to maintain the health of the scalp. In summary, the surfactant compound system provided by the present invention has excellent antistatic properties, hard water resistance, and excellent foam stabilization, dispersion, wetting, and penetration capabilities.

[0021] Preferably, the auxiliary agent includes, by weight, 0.5 to 1.0 parts of preservative, 0.05 to 0.15 parts of softener, and 0.5 to 0.6 parts of emulsifier.

[0022] Preferably, the preservative is selected from phenoxyethanol / ethylhexylglycerin.

[0023] Preferably, the emulsifier is selected from PEG-40 hydrogenated castor oil.

[0024] Preferably, the softener is selected from polyquaternium-10.

[0025] The second aspect of the present invention provides a method for preparing a scalp cleansing liquid with oil control and dandruff removal effects, which specifically comprises the following steps:

[0026] S1. Mix PEG-40 hydrogenated castor oil, menthol and juniper berry essential oil until the materials are completely dissolved, add water and polyquaternium-10, and homogenize;

[0027] S2, add cocamidopropyl betaine, sodium methyl cocoyl taurate, cocoyl glucoside, disodium cocoamphodiacetate and citric acid, and heat and keep warm;

[0028] S3. Add oat alkaloids and glycyrrhetinic acid, keep warm and heat, cool down, add phenoxyethanol / ethylhexylglycerin and azelaic acid, stir until completely dissolved.

[0029] Preferably, the heating in step S2 is heating to 75-80° C., and the insulation time is 18 to 22 minutes.

[0030] Preferably, the duration of the heat preservation and heating in step S3 is 15 to 20 minutes. The present invention can improve the solubility and low temperature stability of the two raw materials, oat alkaloids and glycyrrhetinic acid, by heating and mixing with cocamidopropyl betaine.

[0031] Preferably, the cooling in step S3 is performed by stirring with cooling water to reduce the temperature to 43-47°C.

[0032] Preferably, the stirring in step S3 is performed by using a stirring pot, and the homogenizing in step S1 is performed by using a homogenizer.

[0033] Compared with the prior art, the present invention has the following beneficial effects:

[0034] 1) The present invention intervenes in the three pathways of scalp oil control, antibacterial and metabolism simultaneously to achieve the effects of oil control, dandruff removal and scalp care, helping the scalp to achieve three major balances.

[0035] 2) The glycyrrhetinic acid and azelaic acid used in the present invention cooperate with each other, which can not only effectively inhibit the activity of 5α-reductase, but also inhibit the enzyme process of producing DHT, thereby having a good oil control effect.

[0036] 3) The synergistic combination of azelaic acid, glycyrrhetinic acid and juniper berry essential oil used in the present invention has a good antibacterial effect and can effectively inhibit the growth of harmful bacteria such as Malassezia capitis;

[0037] 4) The combination of oat alkaloids and glycyrrhetinic acid used in the present invention has a good alleviating effect on skin inflammation and can effectively alleviate the impact of inflammation on dandruff;

[0038] 5) The combination of azelaic acid and citric acid used in the present invention promotes the softening and shedding of the aged stratum corneum, constructs the use environment of the product, and citric acid can adjust the pH value of the product system to adapt to the pH value of the scalp, so that the product is more in line with the actual needs of the scalp environment.

[0039] 6) The surfactant compound system provided by the present invention is properly compatible, and cocamidopropyl betaine, sodium methyl cocoyl taurate, cocoyl glucoside, and disodium cocoamphodiacetate are reasonably matched in a specific ratio to form a mild surfactant compound system, which provides stable cleaning power, has high biocompatibility, is stable to acids and alkalis, has rich foam, has excellent antistatic properties, hard water resistance, and excellent foam stabilization, dispersion, wetting, and penetration capabilities.

[0040] 7) The scalp cleansing liquid with oil control and dandruff removal effects provided by the present invention is in the form of a non-viscous semi-permeable to transparent liquid that can quickly foam on the scalp and hair. The product experience is different from that of traditional shampoos and the form of expression is novel. DETAILED DESCRIPTION

[0041] The present invention is further described below in conjunction with the examples. It should be noted that the following examples are only used to explain the present invention, but not to limit the present invention. The experimental methods used in the following examples are conventional methods unless otherwise specified. The materials, reagents, etc. used in the following examples, unless otherwise specified, can all be obtained through commercial channels.

[0042] PEG-40 hydrogenated castor oil was purchased from BASF (China) Co., Ltd. (Article No. CO 40);

[0043] Menthol was purchased from Shanghai White Bear Pharmaceutical Co., Ltd.;

[0044] Cocamidopropyl betaine was purchased from Guangzhou Xingye Technology Co., Ltd. (catalog number: Ucefactant CAB-35);

[0045] Sodium methyl cocoyl taurate was purchased from Zhangjiagang Grete Chemical Co., Ltd. (catalog number: GREMOL CMT-35);

[0046] Coco-glucoside was purchased from BASF (China) Co., Ltd. (Article No. 818UP);

[0047] Disodium cocoamphodiacetate was purchased from BASF (China) Co., Ltd. (catalog number: Dehyton DC-AS);

[0048] Phenoxyethanol / ethylhexylglycerin was purchased from Ashland (China) Investment Co., Ltd. (product name: PE9010);

[0049] Avena sativa alkaloids were purchased from Xi'an Preus Bioengineering Co., Ltd. (product name: dihydroavena sativa alkaloids);

[0050] Juniper berry essential oil was purchased from SASDIFFUSIONS AROMATIQUES (product name: Juniper berry oil);

[0051] Examples 1 to 3

[0052] A scalp cleansing liquid with oil control and dandruff removal effects, specifically comprising the following ingredients:

[0053] Example 1-3 Scalp Cleansing Liquid Formula Table

[0054]

[0055]

[0056] Example 1

[0057] A scalp cleansing liquid with oil control and dandruff removal effects, the preparation method specifically comprises the following steps:

[0058] S1. Put PEG-40 hydrogenated castor oil, menthol and juniper berry essential oil into a stirring pot and stir until the materials are completely dissolved for later use; add water into the stirring pot, add polyquaternium-10, start the homogenizer, and homogenize and disperse the materials;

[0059] S2, add cocamidopropyl betaine, sodium methyl cocoyl taurate, cocoyl glucoside, disodium cocoamphodiacetate and citric acid, start steam heating, heat to 75°C, and keep warm for 18 minutes;

[0060] S3. Add oat alkaloids and glycyrrhetinic acid, heat for 15 minutes, turn on the cooling water and stir to cool down, reduce the temperature to 43°C, add phenoxyethanol / ethylhexylglycerin and azelaic acid, stir until completely dissolved, and the material preparation is completed.

[0061] Example 2

[0062] A scalp cleansing liquid with oil control and dandruff removal effects, the preparation method specifically comprises the following steps:

[0063] S1. Put PEG-40 hydrogenated castor oil, menthol and juniper berry essential oil into a stirring pot and stir until the materials are completely dissolved for later use; add water into the stirring pot, add polyquaternium-10, start the homogenizer, and homogenize and disperse the materials;

[0064] S2, add cocamidopropyl betaine, sodium methyl cocoyl taurate, cocoyl glucoside, disodium cocoamphodiacetate and citric acid, start steam heating, heat to 77°C, and keep warm for 20 minutes;

[0065] S3. Add oat alkaloids and glycyrrhetinic acid, heat for 17 minutes, turn on the cooling water and stir to cool down, reduce the temperature to 47°C, add phenoxyethanol / ethylhexylglycerin and azelaic acid, stir until completely dissolved, and the material preparation is completed.

[0066] Example 3

[0067] A scalp cleansing liquid with oil control and dandruff removal effects, the preparation method specifically comprises the following steps:

[0068] S1. Put PEG-40 hydrogenated castor oil, menthol and juniper berry essential oil into a stirring pot and stir until the materials are completely dissolved for later use; add water into the stirring pot, add polyquaternium-10, start the homogenizer, and homogenize and disperse the materials;

[0069] S2, add cocamidopropyl betaine, sodium methyl cocoyl taurate, cocoyl glucoside, disodium cocoamphodiacetate and citric acid, start steam heating, heat to 80°C, and keep warm for 22 minutes;

[0070] S3. Add oat alkaloids and glycyrrhetinic acid, heat for 20 minutes, turn on the cooling water and stir to cool down, reduce the temperature to 45°C, add phenoxyethanol / ethylhexylglycerin and azelaic acid, stir until completely dissolved, and the material preparation is completed.

[0071] Comparative Example 1

[0072] A scalp cleansing liquid with oil control and dandruff removal effects, which is similar to Example 3, except that glycyrrhetinic acid is replaced with green tea extract.

[0073] Comparative Example 2

[0074] A scalp cleansing liquid with oil control and dandruff removal effects, which is similar to Example 3, except that azelaic acid is replaced by glycolic acid.

[0075] Comparative Example 3

[0076] A scalp cleansing liquid with oil control and dandruff removal effects, which is similar to Example 3, except that the juniper berry essential oil is replaced with water.

[0077] Comparative Example 4

[0078] A scalp cleansing liquid with oil control and dandruff removal effects is similar to Example 3, the only difference being that sodium methyl cocoyl taurate, cocoyl glucoside, and disodium cocoamphodiacetate in the surfactant are all replaced with cocamidopropyl betaine.

[0079] Comparative Example 5

[0080] A scalp cleansing liquid with oil control and dandruff removal effects, which is similar to Example 3, except that the oat alkaloid is replaced by water.

[0081] The following is a performance test of the scalp cleaning solution of the present invention.

[0082] The scalp cleansing liquid formulas of Examples 1 to 3 were tested using the following method to examine their foam, effective substance content, stability, lipid inhibition, and Malassezia inhibition ring test.

[0083] Test Example 1: Test results of foam, active ingredient content and stability of scalp cleansing liquid

[0084] 1. Foam test method: Determine the foaming power of detergents according to GB / T13173 (Ross-Miles method) and read the foam height;

[0085] 2. Test method for active substance content: Test the active substance content according to GB / T5173, and the content evaluation standard is content>10%;

[0086] 3. Stability test method: It refers to testing at four conditions of 25℃, -20℃, 45℃, -20℃ and 45℃ for 3 months. There is no change after returning to normal temperature and it can be used normally. This is used as the evaluation standard.

[0087] The test results are shown in the following table:

[0088] Foam height test results table

[0089] Example 1 Example 2 Example 3 Comparative Example 4 Foam height (mm) 140 138 137 120

[0090] As can be seen from the above table, Examples 1 to 3 of the present invention have abundant foam and a higher effective matter content. Compared with Examples 1 to 3, Comparative Example 4 has a significantly lower foam height due to the change in the surfactant compounding system, indicating that the surfactant compounding system comprising cocamidopropyl betaine, sodium methyl cocoyl taurate, cocoyl glucoside, and disodium cocoamphodiacetate of the present invention has better cleaning power.

[0091] Table of effective substance content and stability test results

[0092] Test product Active ingredient content% stability Example 1 15.3 qualified Example 2 15.5 qualified Example 3 15.4 qualified Comparative Example 1 14.5 qualified Comparative Example 2 14.6 qualified Comparative Example 3 13.0 qualified Comparative Example 4 14.5 qualified Comparative Example 5 13.8 qualified

[0093] Test Example 2: Lipid Inhibition Test of Scalp Cleansing Liquid

[0094] Lipid inhibition detection method: The Ronnie red staining method was used to test the lipid content in human sebaceous gland cells (SZ-95). A blank control was set up in the experiment. The inhibition rate of lipid synthesis in the SZ-95 cells in the experimental group with the test substance added was higher than that in the blank control group, and there was a significant difference (P<0.05). This indicates that the test substance has the ability to inhibit lipid synthesis in SZ-95 cells at this test concentration, which can be used as one of the evidences that the product has the title of oil control.

[0095] The test results are shown in the table below. The experimental results show that at a test sample concentration of 0.003%, the inhibition rate of lipid synthesis in SZ-95 cells is significantly higher than that in the control group, with a statistically significant difference. This result can be used as one of the evidences to support the claim that the product has the effect of oil control:

[0096] Lipid inhibition test results table

[0097] Experimental Blank control group Test sample group P-value Significant difference Example 1 Lipid inhibition rate % 1.51±1.09 23.34±2.45 <0.05 Significant Example 2 Lipid inhibition rate % 1.51±1.09 25.14±2.45 <0.05 Significant Example 3 Lipid inhibition rate % 1.51±1.09 26.02±2.45 <0.05 Significant Comparative Example 1 Lipid inhibition rate % 1.51±1.09 11.38±2.45 <0.05 generally Comparative Example 2 Lipid inhibition rate % 1.51±1.09 12.17±2.45 <0.05 generally

[0098] As can be seen from the above table, Examples 1 to 3 have better antibacterial effects than Comparative Examples 1 and 2. By comparison, it can be seen that after replacing any component of glycyrrhetinic acid or azelaic acid, the lipid inhibition effect is greatly weakened, from which it can be seen that glycyrrhetinic acid and azelaic acid synergistically inhibit the formation of lipids and reduce the lipid content, thereby inhibiting the oiliness of the scalp.

[0099] Test Example 3: Antibacterial Ability Test of Scalp Cleansing Liquid

[0100] Detection method: Malassezia inhibition ring test. One of the important external test methods is to evaluate the anti-dandruff effect by testing the sample's inhibitory effect on Malassezia. Malassezia, also known as Pityrosporum, grows rapidly and has strong infectivity under the inducing factors of high temperature, sweating and chronic infection. A large number of studies have shown that the production of dandruff is directly related to the number of Malassezia, and inhibiting the growth of Malassezia can achieve the effect of anti-dandruff.

[0101] The test results are shown in the following table:

[0102] Malassezia inhibition ring test results table

[0103]

[0104] Under the experimental conditions, the antibacterial ring diameter of the test sample for Malassezia furfur was >7mm, and no antibacterial ring was produced in the negative control, indicating that the test sample has an inhibitory effect on Malassezia, and can achieve the antidandruff effect by inhibiting the proliferation of Malassezia. Compared with Examples 1 to 3, the antibacterial ring diameters of Comparative Examples 1 to 3 are greatly reduced. It can be seen that after replacing any of the three components of glycyrrhetinic acid, azelaic acid, and juniper berry essential oil, the inhibitory effect on bacteria is reduced, and the three components work together to achieve a better antibacterial effect.

[0105] In summary, the formula system meets the national standards for shampoo and has good oil control and anti-dandruff effects. Through the reasonable selection and proportion of each component, the oil control and anti-dandruff cleansing liquid provided by the present invention as a whole can achieve oil control and dandruff removal from three aspects: controlling oil secretion, inhibiting harmful bacteria, and promoting keratin metabolism, thereby maintaining scalp health and providing a new product solution for oil control and anti-dandruff products.

Claims

1. A scalp cleansing liquid with oil control and dandruff removal effects, characterized in that: The invention comprises the following components in parts by mass: 0.1 to 0.2 parts of juniper berry essential oil, 0.1 to 0.15 parts of menthol, 42.0 to 61.0 parts of surfactants, 0.05 to 0.15 parts of citric acid, 0.5 to 1.0 parts of azelaic acid, 0.15 to 0.25 parts of oat alkaloids, 0.08 to 0.1 parts of glycyrrhetinic acid, 36.72 to 54.85 parts of water, and 1.05 to 1.75 parts of auxiliary agents.

2. The scalp cleansing liquid with oil control and dandruff removal effect according to claim 1, characterized in that: Calculated by weight, the surfactant consists of 35.0-45.0 parts of cocamidopropyl betaine, 3.0-7.0 parts of sodium methyl cocoyl taurate, 1.0-2.0 parts of cocoyl glucoside, and 3.0-7.0 parts of disodium cocoamphodiacetate.

3. The scalp cleansing liquid with oil control and dandruff removal effect according to claim 1, characterized in that: The auxiliary agent comprises the following components in parts by mass: 0.5 to 1.0 parts of preservatives, 0.05 to 0.15 parts of softeners, and 0.5 to 0.6 parts of emulsifiers.

4. The scalp cleansing liquid with oil control and dandruff removal effect according to claim 3, characterized in that: The preservative is selected from phenoxyethanol / ethylhexylglycerin; The emulsifier is selected from PEG-40 hydrogenated castor oil; The softener is selected from polyquaternium-10.

5. A method for preparing the scalp cleansing liquid with oil control and dandruff removal effect as claimed in any one of claims 1 to 4, characterized in that: The following steps are involved: S1. Mix PEG-40 hydrogenated castor oil, menthol and juniper berry essential oil until the materials are completely dissolved, add water and polyquaternium-10, and homogenize; S2, add cocamidopropyl betaine, sodium methyl cocoyl taurate, cocoyl glucoside, disodium cocoamphodiacetate and citric acid, and heat and keep warm; S3. Add oat alkaloids and glycyrrhetinic acid, keep warm and heat, cool down, add phenoxyethanol / ethylhexylglycerin and azelaic acid, stir until completely dissolved.

6. The preparation method according to claim 5, characterized in that: The heating in step S2 is heating to 75-80°C.

7. The preparation method according to claim 5, characterized in that: The insulation time in step S2 is 18 to 22 minutes.

8. The preparation method according to claim 5, characterized in that: The duration of the heat preservation and heating in step S3 is 15 to 20 minutes.

9. The preparation method according to claim 5, characterized in that: The cooling in step S3 is performed by stirring with cooling water to reduce the temperature to 43-47°C.

10. The preparation method according to claim 5, characterized in that: The stirring in step S3 is performed by using a stirring pot, and the homogenizing in step S1 is performed by using a homogenizer.

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