Ear drops for treating otitis media and preparation method thereof

Abstract

The invention discloses an ear drop for treating otitis media and a preparation method thereof in the technical field of otitis media treatment, and the ear drop comprises the following raw materials in parts by weight: 10-60 parts of coptis chinensis, 5-20 parts of boric acid, 6-20 parts of borneol and 600-1300 parts of boiling water. According to the invention, coptis chinensis has a good treatment effect on inflammation and infection caused by otitis media, boric acid has astringency and antibacterial effects and can effectively reduce auditory meatus secretions and promote inflammation regression, and borneol can relieve pain and discomfort caused by otitis media; and by using boiling water, effective components of the medicinal materials are fully extracted in the preparation process, and meanwhile, the concentration and viscosity of the ear drops are adjusted, so that the ear drops are more suitable for the auditory meatus environment, the irritation of the ear drops is reduced, and meanwhile, the volatilization time of the ear drops in the ears of a patient is shortened.

Description

Technical Field

[0001] The invention relates to the technical field of otitis media treatment, and in particular to an ear drop medicine for treating otitis media and a preparation method thereof. Background Art

[0002] The main causes of otitis media include bacterial and viral infections, which are often caused by diseases such as colds, flu, sinusitis or rhinitis. In addition, factors such as changes in air pressure, dirty water in the ears, excessive smoking, and earwax accumulation may also induce otitis media.

[0003] Otitis media can be further divided into two categories: non-suppurative and suppurative:

[0004] Non-suppurative otitis media: mainly includes secretory otitis media and barotraumatic otitis media (such as otitis media that may be caused by flying or diving).

[0005] Suppurative otitis media: divided into acute and chronic types.

[0006] The main clinical symptoms of otitis media include:

[0007] Earache: After the disease occurs, inflammation may stimulate the sensory nerve endings in the ear cavity, causing ear pain.

[0008] Hearing loss: When inflammation occurs in the middle ear, fluid may accumulate in the middle ear, blocking the conduction of sound and causing hearing loss.

[0009] Ear canal secretions: Inflammation may destroy the normal structure and function of the middle ear mucosa, leading to increased mucosal exudate, causing water, pus or even bleeding in the ear canal.

[0010] Tinnitus and ear stuffiness: The disease can also cause Eustachian tube dysfunction and may cause changes in the pressure in the middle ear, causing tinnitus and ear stuffiness.

[0011] In addition, patients may also have systemic symptoms, such as fever, headache, etc. For children, there may also be gastrointestinal reactions, such as diarrhea, or rubbing or scratching the ears.

[0012] The treatment of otitis media generally includes drug therapy, surgical treatment and auxiliary treatment.

[0013] In drug treatment, ear drops are usually used for treatment. In the preparation process of ear drops, the drug is usually soaked. Existing ear drops are usually prepared using organic solvents such as propylene glycol, polyethylene glycol and ethanol. These ear drops prepared using organic solvents are generally highly irritating. At the same time, some organic solvents are highly volatile. Ear drops prepared using these solvents may stay in the patient's ear for a short time and have poor therapeutic effects.

[0014] Therefore, the present invention provides an ear drop medicine for treating otitis media and a preparation method thereof, which reduces the irritation of the ear drop and reduces the volatilization time of the ear drop in the patient's ear. Summary of the invention

[0015] In order to solve the above problems, the present invention provides an ear drop medicine for treating otitis media and a preparation method thereof, which reduces the irritation of the ear drop and reduces the volatilization time of the ear drop in the patient's ear.

[0016] In order to achieve the above purpose, the technical scheme of the present invention is as follows: an ear drop medicine for treating otitis media, whose raw material composition and weight ratio are as follows: 10-60 parts of coptis root, 5-20 parts of boric acid, 6-20 parts of borneol, and 600-1300 parts of boiling water.

[0017] Furthermore, the raw material composition and weight ratio are as follows: 10 parts of coptis root, 5 parts of boric acid, 6 parts of borneol and 600 parts of boiling water.

[0018] Furthermore, in terms of weight, the raw material composition and weight ratio are: 30 parts of coptis root, 13 parts of boric acid, 15 parts of borneol and 900 parts of boiling water.

[0019] Furthermore, in terms of weight, the raw material composition and weight ratio are: 60 parts of coptis root, 20 parts of boric acid, 20 parts of borneol and 1300 parts of boiling water.

[0020] Furthermore, a method for preparing ear drops for treating otitis media comprises the following specific steps:

[0021] Step 1: Raw material processing: washing and air-drying the coptis root, and evenly cutting it into slices;

[0022] Step 2: soaking and extracting, putting coptis root, boric acid and borneol into a soaking device according to a certain proportion, and then adding boiling water into the soaking device according to a certain proportion;

[0023] Step 3: Residue treatment: regularly rotate the soaking device to clean and collect the residues precipitated at the bottom;

[0024] Step 4: Bottle and use. After soaking, pour the obtained medicine into a dropper bottle prepared in advance, and treat the patient with otitis media by squeezing the dropper bottle on time.

[0025] Furthermore, in the step 2, the soaking period is 10-27 days.

[0026] Furthermore, in step 4, the standard of use is 3 times a day, 2-3 drops each time.

[0027] Furthermore, in step 4, the usage period is 5-7 days.

[0028] Further, in the steps 2 and 3, the soaking device includes a base and a soaking box, the soaking box is installed on the top of the base, and the soaking box is respectively provided with a feed port and a discharge port; a rotating shaft is provided inside the soaking box, the soaking box and the rotating shaft are rotatably matched, one end of the rotating shaft passes through the side wall of the soaking box and extends to the outside of the soaking box and is fixedly connected with a handle; a plurality of stirring components fixedly connected to the rotating shaft are provided in the soaking box, a top block located in the motion track of the stirring component is fixedly connected to one inner side wall of the soaking box, and a collecting net is provided on the other inner side wall of the soaking box, and the collecting net is inclined and located in the motion track of the stirring component;

[0029] The stirring components all include a support rod fixedly connected to the rotating shaft, a guide seat is hinged at one end of the support rod away from the rotating shaft, and a torsion spring is provided at the hinge between the support rod and the guide seat, an arc-shaped scooping plate is fixedly connected to one end of the guide seat away from the support rod, a plurality of through holes are provided on the scooping plate, a protrusion is provided on one side of the guide seat close to the top block, and the top block is located within the movement trajectory of the protrusion; the collecting net is located within the movement trajectory of the scooping plate.

[0030] Furthermore, the top block is divided into a guide area and a shaking area, and the diameter of the guide area is larger than the diameter of the shaking area.

[0031] The above scheme has the following beneficial effects:

[0032] 1. In the present invention, as a traditional Chinese medicinal material, coptis root has the effects of clearing away heat and detoxifying, drying dampness and stopping dysentery, and has a good inhibitory effect on inflammation and infection caused by otitis media; boric acid has astringent and antiseptic effects, can reduce secretions in the ear canal, and promote the disappearance of inflammation; and borneol can effectively relieve the pain and discomfort caused by otitis media due to its cooling and analgesic properties. In the preparation process, the boiling water extraction method is adopted, and the raw materials such as coptis root, boric acid and borneol are added to boiling water according to the ratio, and the effective ingredients are extracted and made into ear drops through the steps of soaking, stirring and filtering. This method is not only simple to operate, easy to control, but also can fully retain the effective ingredients in the raw materials, and improve the efficacy of ear drops. By optimizing the raw material ratio and the preparation process, not only the effective treatment of otitis media is achieved, but also the irritation of ear drops is significantly reduced, and the volatilization time of ear drops in the patient's ear is reduced, thereby improving the therapeutic effect and the comfort of the patient.

[0033] 2. In this scheme, the air-drying and dicing of Coptis chinensis can improve the efficiency of the effective ingredients of the drug being dissolved in water during the subsequent soaking process. However, the internal fiber structure of the pretreated Coptis chinensis is easily damaged during the soaking process, which leads to easy slag falling during the soaking process. The soaking device can rotate the soaking device regularly through the design of the rotating shaft and the stirring component, so that the Coptis chinensis, boric acid and borneol are soaked more evenly in boiling water, which is conducive to the full dissolution and extraction of the effective ingredients, thereby improving the concentration and uniformity of the medicinal solution and ensuring the stability and reliability of the efficacy. The soaking days are within 10-27 days, which not only ensures the full release of the medicinal ingredients, but also avoids the deterioration of the medicinal solution or the loss of effective ingredients that may be caused by long-term soaking.

[0034] During the rotation of the scooping plate in the stirring assembly, it will be squeezed and pushed by the top block, causing shaking, shaking off the drug residue attached to it, and collecting it through the collection net. This design can automatically clean the drug residue during the soaking process, reducing the trouble and cost of manual cleaning. The design of regularly rotating the soaking device and automatically cleaning the drug residue can effectively prevent the drug residue from depositing at the bottom of the soaking box, avoiding the negative impact of the drug residue on the quality of the drug solution. It also facilitates the subsequent processing and bottling of the drug solution, reducing the possibility of drug residue blocking the discharge port during the bottling process.

[0035] Additional aspects and advantages of the present invention will be given in part in the following description and in part will be obvious from the following description, or will be learned through practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0036] Figure 1 A flow chart of an embodiment of a method for preparing ear drops for treating otitis media according to the present invention;

[0037] Figure 2 It is a front view of the soaking device in the method for preparing ear drops for treating otitis media of the present invention;

[0038] Figure 3 It is a side sectional view of the soaking device in the method for preparing ear drops for treating otitis media of the present invention;

[0039] Figure 4 It is a side sectional view of a scooping plate of an immersion device in the method for preparing ear drops for treating otitis media of the present invention;

[0040] Figure 5 The present invention is a front cross-sectional view of the top block of the soaking device in the method for preparing ear drops for treating otitis media.

[0041] The figure marks in the drawings of the specification include: 1, soaking box; 101, feed port; 102, discharge port; 2, base; 3, handle; 4, rotating shaft; 5, collecting net; 6, scooping plate; 7, guide seat; 8, bump; 9, support rod; 10, top block. DETAILED DESCRIPTION

[0042] The technical solution of the present invention will be described clearly and completely below in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0043] In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the present invention. In addition, the terms "first", "second", and "third" are used for descriptive purposes only, and cannot be understood as indicating or implying relative importance.

[0044] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0045] The following is further described in detail through specific implementation methods:

[0046] Embodiment 1:

[0047] The invention discloses an ear drop medicine for treating otitis media. The raw material composition and weight ratio thereof are as follows: 20-70 parts of coptis root, 10-26 parts of boric acid, 13-27 parts of borneol and 900-1600 parts of boiling water.

[0048] Embodiment 2:

[0049] The difference from the above embodiment is that, an ear drop medicine for treating otitis media has the following raw material composition and weight ratio, measured by weight: 10 parts of coptis root, 5 parts of boric acid, 6 parts of borneol and 600 parts of boiling water.

[0050] Embodiment 3:

[0051] The difference from the above embodiment is that, an ear drop medicine for treating otitis media has the following raw material composition and weight ratio, calculated by weight: 30 parts of coptis root, 13 parts of boric acid, 15 parts of borneol and 900 parts of boiling water.

[0052] Embodiment 4:

[0053] The difference from the above embodiment is that, in terms of weight, the raw material composition and weight ratio are: 60 parts of coptis root, 20 parts of boric acid, 20 parts of borneol and 1300 parts of boiling water.

[0054] Embodiment 5:

[0055] The difference from the above embodiment is that, Figure 1 As shown, a method for preparing ear drops for treating otitis media comprises the following specific steps:

[0056] Step 1: Raw material processing: wash and air-dry the above-mentioned Coptis chinensis, and cut it into slices evenly.

[0057] Step 2: soaking and extracting, put coptis root, boric acid and borneol into a soaking device according to proportion, and then add boiling water into the soaking device according to the corresponding proportion; wherein the soaking days are 10-27 days.

[0058] In the steps 2 and 3, the soaking device includes a base 2 and a soaking box 1, the soaking box 1 is installed on the top of the base 2, and the soaking box 1 is respectively provided with a feed port 101 and a discharge port 102, and a filtering device such as a filter mesh can be provided at the discharge port 102; a rotating shaft 4 is provided inside the soaking box 1, and the soaking box 1 rotates with the rotating shaft 4, one end of the rotating shaft 4 passes through the side wall of the soaking box 1 and extends to the outside of the soaking box 1 and is fixedly connected with a handle 3 by screws; a plurality of stirring components fixedly connected to the rotating shaft 4 are provided in the soaking box 1, and a top block 10 located within the motion track of the stirring component is integrally formed on one inner side wall of the soaking box 1, and a collecting net 5 is integrally formed on the other inner side wall of the soaking box 1, and the collecting net 5 is inclined and located within the motion track of the stirring component;

[0059] The stirring components all include a support rod 9 fixedly connected to the rotating shaft 4 by screws, a guide seat 7 is hinged at one end of the support rod 9 away from the rotating shaft 4, and a torsion spring is provided at the hinge of the support rod 9 and the guide seat 7, an arc-shaped scooping plate 6 is fixedly connected to one end of the guide seat 7 away from the support rod 9, and a plurality of through holes are provided on the scooping plate 6, and the diameter of the through holes can be less than 0.1 mm to ensure sufficient scooping of the raw material residue, and a convex block 8 ( Figure 2 ), the top block 10 is located within the movement trajectory of the protrusion 8; the collecting net 5 is located within the movement trajectory of the scooping plate 6.

[0060] At the same time, since the volume of the medicinal residue is small, it is easy to adhere to the scooping plate 6 after being soaked in water and is not easy to fall off. Therefore, the top block 10 is divided into a guide area and a shaking area. The diameter of the guide area is larger than the diameter of the shaking area. Through the change of the curvature of the edge of the top block 10 (from slow to fast), when the protrusion 8 contacts the shaking area, the speed is greatly accelerated and then greatly reduced, so that the scooping plate 6 swings violently, and the medicinal residue therein is thrown into the collection net 5 due to inertia.

[0061] Step three, drug residue treatment, regularly rotate the soaking device to clean and collect the residue precipitated at the bottom.

[0062] Step 4: Bottling and using. After soaking, pour the obtained medicine into a prepared dropper bottle, and treat the otitis media patient on time by squeezing the dropper bottle. The standard usage is 3 times a day, 2-3 drops each time, and the usage cycle is 5-7 days.

[0063] The specific implementation process of the soaking device is as follows: put the raw materials into the soaking box 1 according to the ratio, add boiling water through the feed port 101, and manually rotate the handle 3 regularly to stir, so as to ensure that the raw materials are fully soaked and the effective components are extracted. At the same time, the internal fiber structure of the treated Coptis chinensis is easily damaged during the soaking process, and the internal structure of Coptis chinensis is also easily loosened in boiling water, which increases the possibility of slag falling during the soaking process. Thus, during the periodic stirring process, when the rotating shaft 4 rotates and drives the support rod 9, the guide seat 7 and the scooping plate 6, as the support rod 9, the guide seat 7 and the scooping plate 6 stir the liquid in the immersion box 1, the raw material residue at the bottom of the immersion box 1 will be suspended in the liquid, and at the same time, as the scooping plate 6 moves in the liquid, the raw material residue and part of the raw material are scooped up. When the protrusion 8 on the guide seat 7 contacts the top block 10, the guide seat 7 is hinged to the support rod 9, so that the guide seat 7 rotates around the hinge point, even if the scooping plate 6 is flipped toward the collecting net 5, and as the top block 10 further contacts with the protrusion 8, the scooping plate 6 and the guide seat 7 are moved. After violent flipping, after the protrusion 8 passes through the shaking area on the top block 10, due to the action of the torsion spring, the scooping plate 6 and the guide seat 7 are quickly reset, so that the drug residue in the scooping plate 6 is thrown into the collection net 5 due to inertia, and some raw materials may also be thrown into the collection net 5. At this time, through the inclined setting of the collection net 5, these raw materials overcome the friction due to their own gravity and fall back into the medicine along the inclined collection net 5 to continue soaking, ensuring the therapeutic effect of the finished product, while the raw material residue cannot overcome the friction due to its small mass and the tension of the liquid on the surface of the collection net 5, so it is left in the collection net 5 to complete the cleaning of the drug residue. Improve the quality of the subsequent finished ear drops, reduce the possibility of raw material impurities, and also reduce the possibility of blockage of the discharge port 102.

[0064] Among the patients who select many ear drops made with this scheme, three of them are visited again, and the curative effect of this scheme for otitis media is illustrated.Specific as follows: 1, the patient is an elderly woman, and the history of otitis media is as long as 5-6 years, and may be accompanied by symptoms such as increased ear canal secretions, hearing loss, and otalgia. The ear drops in this scheme are used for treatment. According to the raw material proportioning in embodiment 4 (60 parts of coptis root, 20 parts of boric acid, 20 parts of borneol, 1300 parts of boiling water), the preparation method in embodiment 5 is followed to prepare ear drops. Before treatment, the ear canal of the patient is cleaned first, and it is ensured that there is no excessive secretion or cerumen, and the ear drops prepared are dripped into the patient's ear canal using a dropper bottle, 2-3 drops each time, 3 times a day. According to his own account and the description of his family, after using this ear drop medicine, the patient's condition began to improve in about 15 days, and then after a week of continuous treatment, the patient's otitis media symptoms completely disappeared, ear canal secretions decreased, hearing was restored, ear pain disappeared, and during the follow-up visit, he was able to talk freely with the follow-up personnel, accurately hear the follow-up personnel's questions, and respond accordingly. 2. The second patient is a young male with a short history of otitis media, about half a year. He also has symptoms such as ear pain and slight hearing loss, but because of the short time, his symptoms are not as severe as those of the first patient, but it also affects his daily life. The same treatment plan as the first patient is used for ear drops. First, clean the patient's ear canal, and drop the medicine at a dose of 2-3 drops 3 times a day. Due to the patient's short medical history, the treatment cycle is expected to be relatively short. According to his own account, the symptoms of otitis media completely disappeared after about 10 days. And during the follow-up visit, it was learned that after using this ear drop medicine to cure his otitis media, otitis media has not recurred in the subsequent life. 3. The third patient who was revisited was also an elderly woman, about 93 years old. Her history of otitis media was the longest among the three, about 10 years. She had hearing loss, and this symptom was particularly obvious when pus flowed in her ears. During this period, she tried many other treatment options. Although these treatment options may have obvious therapeutic effects in the early stage of treatment, the patient's otitis media also recurred again afterwards, causing the otitis media to last for so long and not be cured. In the revisit, according to her description, after she was treated with the ear drops in this scheme, after about 17 days of treatment, the patient's otitis media symptoms were significantly relieved, hearing was restored, ear canal secretions decreased, ear pain disappeared, and after continuing to consolidate treatment for a period of time (about a week), the patient was completely cured. And from her description, it is known that after she was cured with this ear drop, the time interval between our revisit was about two years, during which her otitis media did not recur.

[0065] Obviously, the above embodiments are merely examples for the purpose of clear explanation, and are not intended to limit the implementation methods. For those skilled in the art, other different forms of changes or modifications can be made based on the above description. It is not necessary and impossible to list all the implementation methods here. The obvious changes or modifications derived therefrom are still within the scope of protection of the invention.

Claims

1. An ear drop medicine for treating otitis media, characterized in that: The raw material composition and weight ratio are as follows: 10-60 parts of coptis root, 5-20 parts of boric acid, 6-20 parts of borneol and 600-1300 parts of boiling water.

2. The ear drops for treating otitis media according to claim 1, characterized in that: The raw material composition and weight ratio are as follows: 10 parts of coptis root, 5 parts of boric acid, 6 parts of borneol and 600 parts of boiling water.

3. The ear drops for treating otitis media according to claim 1, characterized in that: The raw material composition and weight ratio are as follows: 30 parts of coptis root, 13 parts of boric acid, 15 parts of borneol and 900 parts of boiling water.

4. The ear drops for treating otitis media according to claim 1, characterized in that: The raw material composition and weight ratio are as follows: 60 parts of coptis root, 20 parts of boric acid, 20 parts of borneol and 1300 parts of boiling water.

5. A method for preparing ear drops for treating otitis media, characterized in that: The method for preparing the ear drops for treating otitis media according to any one of claims 1 to 4, comprising the following specific steps: Step 1: Raw material processing: washing and air-drying the coptis root, and evenly cutting it into slices; Step 2: soaking and extracting, putting coptis root, boric acid and borneol into a soaking device according to a certain proportion, and then adding boiling water into the soaking device according to a certain proportion; Step 3: Residue treatment: regularly rotate the soaking device to clean and collect the residues precipitated at the bottom; Step 4: Bottle and use. After soaking, pour the obtained medicine into a dropper bottle prepared in advance, and treat the patient with otitis media by squeezing the dropper bottle on time.

6. The method for preparing ear drops for treating otitis media according to claim 5, characterized in that: In the step 2, the soaking days are 10-27 days.

7. The method for preparing ear drops for treating otitis media according to claim 6, characterized in that: In step 4, the standard of use is 3 times a day, 2-3 drops each time.

8. The method for preparing ear drops for treating otitis media according to claim 7, characterized in that: In step 4, the use period is 5-7 days.

9. The method for preparing ear drops for treating otitis media according to claim 8, characterized in that: In the steps 2 and 3, the soaking device comprises a base (2) and a soaking box (1), the soaking box (1) is mounted on the top of the base (2), and the soaking box (1) is respectively provided with a feed port (101) and a discharge port (102); a rotating shaft (4) is provided inside the soaking box (1), the soaking box (1) and the rotating shaft (4) are rotatably matched, one end of the rotating shaft (4) passes through the side wall of the soaking box (1) and extends to the outside of the soaking box (1) and is fixedly connected to a handle (3); a plurality of stirring components fixedly connected to the rotating shaft (4) are provided inside the soaking box (1), a top block (10) located within the movement track of the stirring components is fixedly connected to one inner side wall of the soaking box (1), and a collecting net (5) is provided on the other inner side wall of the soaking box (1), and the collecting net (5) is arranged obliquely and located within the movement track of the stirring components; The stirring components all comprise a support rod (9) fixedly connected to the rotating shaft (4); the support rod (9) is hingedly connected to a guide seat (7) at one end away from the rotating shaft (4); a torsion spring is provided at the hinge between the support rod (9) and the guide seat (7); the guide seat (7) is fixedly connected to an arc-shaped scooping plate (6) at one end away from the support rod (9); a plurality of through holes are provided on the scooping plate (6); a convex block (8) is provided on one side of the guide seat (7) close to the top block (10); the top block (10) is located within the movement track of the convex block (8); and the collecting net (5) is located within the movement track of the scooping plate (6).

10. The method for preparing ear drops for treating otitis media according to claim 9, characterized in that: The top block (10) is divided into a guide area and a shaking area, and the diameter of the guide area is larger than the diameter of the shaking area.

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