Photodynamic therapy device and endoscope system

Abstract

The embodiment of the invention discloses a photodynamic therapy device and an endoscope system, and relates to the technical field of endoscopes. The photodynamic therapy device comprises: a light source for providing therapy light; the incident end of the light guide part is coupled with the light source, and the light guide part is used for guiding out treatment light; the focus-adjustable lens group is arranged at the emergent end of the light guide part and is used for adjusting the divergence angle of the treatment light emitted from the light guide part according to the control signal; and the controller is respectively connected with the light source and the focus-adjustable lens group, and is configured to drive the focus-adjustable lens group according to the received signal containing the target divergence angle, so that the treatment light is emitted according to the target divergence angle. Based on the scheme, the photodynamic therapy operation process can be simplified, the operation burden of a doctor is reduced, and the treatment efficiency is improved.

Description

Technical Field

[0001] The present invention relates to the technical field of endoscopes, and in particular to a photodynamic therapy device and an endoscope system. Background Art

[0002] Photodynamic therapy uses photosensitizers enriched in tumor tissues to react with oxygen molecules in tissues under laser excitation of specific wavelengths (for example, 400-760 nm) to generate cytotoxic reactive oxygen species, which can destroy a variety of biological macromolecules in cells, thereby inducing tumor cell apoptosis to achieve a therapeutic effect.

[0003] In the relevant endoscopic photodynamic therapy, the light-guiding optical fiber is inserted into the body cavity through the surgical instrument channel, the tumor tissue site is determined by fluorescence diagnostic positioning or manual marking by the doctor, and then the position of the scope is adjusted to irradiate the tumor tissue. Among them, since the area of ​​the tumor tissue site varies, when performing photodynamic therapy, in order to ensure that the treatment spot can cover the entire area of ​​the tumor tissue site and at the same time, minimize the burning of the surrounding normal tissue, the actual operation process needs to repeatedly adjust the distance between the light-guiding optical fiber output end of the treatment light and the tumor tissue site and its irradiation position, which imposes a large operating burden on doctors and is inefficient.

[0004] It can be seen that the complicated operation and low efficiency of photodynamic therapy are technical problems that people in this field urgently need to solve. Summary of the invention

[0005] The purpose of the present invention is to provide a photodynamic therapy device and an endoscope system to solve the problems of complicated operation and low efficiency of photodynamic therapy.

[0006] In order to solve the above technical problems, the present invention provides a photodynamic therapy device, comprising:

[0007] a light source for providing therapeutic light;

[0008] A light guide component, whose incident end is coupled to the light source and is used to guide the therapeutic light;

[0009] A focusable lens assembly, which is arranged at the exit end of the light guide component and is used to adjust the divergence angle of the therapeutic light emitted from the light guide component according to a control signal;

[0010] A controller is connected to the light source and the focusable lens group respectively, and is configured to drive the focusable lens group according to a received signal containing a target divergence angle, so that the therapeutic light is emitted according to the target divergence angle.

[0011] Exemplarily, the adjustable focus lens group includes a deformable lens or a refractive index adjustable lens.

[0012] Exemplarily, the deformable lens is a piezoelectrically actuated deformable lens or a liquid lens.

[0013] Exemplarily, the light guiding component includes an optical fiber bundle and a collimator disposed at an output end of the optical fiber bundle.

[0014] Exemplarily, the controller is further configured to:

[0015] The energy output value of the light source is adjusted according to the target divergence angle.

[0016] Exemplarily, in the initial startup state, the controller is further configured to:

[0017] The energy output value of the light source is controlled to be less than or equal to a preset threshold value, and / or the focusable lens group is driven so that the therapeutic light is emitted at a minimum divergence angle.

[0018] In order to solve the above technical problems, the present invention also provides an endoscope system, comprising: an imaging device, a processor and the above photodynamic therapy device, wherein the processor is respectively connected to the imaging device and the controller in the photodynamic therapy device for communication, wherein:

[0019] The imaging device is configured to capture a real-time image of the subject;

[0020] The processor is configured to identify a target area in the real-time image, calculate a target divergence angle matching the target area, and send a signal containing the target divergence angle to the controller, so that the controller drives the focusable lens group according to the signal containing the target divergence angle, thereby causing the therapeutic light to be emitted according to the target divergence angle.

[0021] Exemplarily, the calculating a target divergence angle adapted to the target area includes:

[0022] A target divergence angle matched with the target area is calculated according to the priori parameters of the imaging device and the size information of the target area in the real-time image.

[0023] Exemplarily, the processor is configured to: in response to executing a treatment instruction, send a signal including the target divergence angle to the controller;

[0024] or,

[0025] The controller is configured to:

[0026] In response to executing the treatment instruction, the focus-adjustable lens group is driven according to the received signal containing the target divergence angle, so that the treatment light is emitted according to the target divergence angle.

[0027] Exemplarily, the processor is further configured to automatically trigger the execution of the treatment instruction when it is detected that the center of the spot of the treatment light overlaps with the center of the target area.

[0028] The photodynamic therapy device provided by the present invention can make the therapeutic light emit at any given divergence angle (i.e., target divergence angle) by setting a focusable lens group driven by a controller at the emission end of the light guide component. Among them, since the size of the therapeutic spot irradiated by the therapeutic light on the irradiation surface (e.g., the surface where the tumor tissue site is located) is positively correlated with the irradiation distance and the divergence angle of the therapeutic light, the photodynamic therapy device provided by the present invention can achieve adaptive adjustment of the size of the therapeutic spot irradiated on the irradiation surface by adjusting the divergence angle of the emitted therapeutic light through the focusable lens group. Therefore, when the photodynamic therapy device provided by the present invention is used to perform photodynamic therapy on the target area (e.g., the tumor tissue site), the divergence angle of the therapeutic light can be adaptively adjusted according to the size of the target area, so that the therapeutic spot can just cover the target area. During this period, there is no need to repeatedly adjust the distance between the therapeutic light emission end and the target area (i.e., the irradiation distance), which simplifies the photodynamic therapy operation process, reduces the doctor's operating burden, and improves the treatment efficiency.

[0029] In addition, the present invention also provides an endoscope system, which has the same or corresponding technical features as the above-mentioned photodynamic therapy device and has the same effects as above. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] In order to more clearly illustrate the embodiments of the present invention, the following briefly introduces the drawings required for use in the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0031] Figure 1 A schematic diagram of a photodynamic therapy device provided by an embodiment of the present invention;

[0032] Figure 2 A schematic diagram of a change in the divergence angle of a therapeutic light provided by an embodiment of the present invention;

[0033] Figure 3 A schematic diagram of an endoscope system provided by an embodiment of the present invention;

[0034] Figure 4 A structural diagram of an endoscope system provided by an embodiment of the present invention;

[0035] Figure 5 A schematic diagram of calculating the divergence angle of therapeutic light provided by an embodiment of the present invention.

[0036] The reference numerals are as follows: 1 is a light source, 2 is a light guide component, 3 is a focusable lens group, 4 is a controller, 5 is an irradiation surface, 6 is an imaging device, 7 is a processor, 8 is a photodynamic therapy device, 9 is an endoscope body insertion part, 21 is an optical fiber bundle, 22 is a collimator, 31 is a deformable lens, 61 is a CMOS image sensor, and 71 is an image processor. DETAILED DESCRIPTION

[0037] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0038] The core of the present invention is to provide a photodynamic therapy device and an endoscope system to solve the problems of complicated operation and low efficiency of photodynamic therapy.

[0039] The mainstream scheme of endoscopic photodynamic therapy is to insert the light-guiding fiber into the body cavity through the surgical instrument channel, and determine the location of the tumor tissue by fluorescence diagnosis or manual marking by the doctor. In practice, tumor tissue sites vary in size, and in order to allow the treatment spot to cover tumor tissue sites of different sizes, the size of the treatment spot needs to be adjusted.

[0040] Among them, since the size of the treatment spot is positively correlated with the irradiation distance, that is, the closer the output end of the light-guiding optical fiber is to the tumor tissue site, the smaller the treatment spot formed by the emitted treatment light on the tumor tissue site, therefore, the existing photodynamic therapy device usually adjusts the spot size by adjusting the distance between the output end of the light-guiding optical fiber and the tumor tissue site. However, since the output end of the light-guiding optical fiber is far away from the operating end of the medical staff (i.e., the end held by the medical staff), and there are multiple irregular curved sections between the two ends due to the influence of the cavity, the process of adjusting the irradiation distance will cause a large operating burden on the doctor, thereby greatly reducing the efficiency of photodynamic therapy.

[0041] In order to solve the above-mentioned technical problems, after careful research, it was found that the size of the therapeutic spot irradiated on the tumor tissue is not only positively correlated with the irradiation distance, but also positively correlated with the divergence angle of the therapeutic light itself. That is, at the same irradiation distance, the smaller the divergence angle of the therapeutic light, the smaller the therapeutic spot irradiated on the tumor tissue.

[0042] Based on this, the present invention provides a photodynamic therapy device and an endoscope system that can automatically adjust the size of the treatment spot according to the size of the lesion, so as to avoid burning normal tissue while ensuring the treatment effect, reduce the doctor's operating burden, and improve the treatment efficiency.

[0043] In order to enable those skilled in the art to better understand the scheme of the present invention, the present invention is further described in detail below in conjunction with the accompanying drawings and specific implementation methods. Figure 1 A schematic diagram of a photodynamic therapy device provided by an embodiment of the present invention is shown in FIG. Figure 1 As shown, the photodynamic therapy device may include but is not limited to: a light source 1 for providing therapeutic light; a light guide component 2, whose incident end is coupled to the light source 1 and is used to derive the therapeutic light; an adjustable focus lens group 3, which is arranged at the output end of the light guide component 2 and is used to adjust the divergence angle of the therapeutic light emitted from the light guide component 2 according to a control signal; a controller 4, which is respectively connected to the light source 1 and the adjustable focus lens group 3, and is configured to drive the adjustable focus lens group 3 according to a received signal containing a target divergence angle, so that the therapeutic light is emitted according to the target divergence angle.

[0044] Among them, the light source 1 can be any device or equipment that can provide therapeutic light, and the therapeutic light can be any light beam that can achieve the purpose of treatment. The present application does not limit the light source 1 used and the wavelength of the therapeutic light provided, which can be determined according to actual conditions. For example, when the light source 1 is used as a light source for treating tumor tissue, the photosensitizer enriched in the tumor tissue reacts with oxygen molecules in the tissue under laser excitation of a specific wavelength (400-760nm) to generate cytotoxic reactive oxygen species, which can destroy a variety of biological macromolecules in the cell, thereby inducing tumor cell apoptosis to achieve a therapeutic effect. Therefore, the therapeutic light provided by the light source 1 can be a laser with a wavelength of 400-760nm.

[0045] The light guide component 2 may be any light guide medium that can guide the therapeutic light, for example, an optical fiber bundle. In this embodiment, in order to reduce the divergence of the therapeutic light emitted by the light source 1 and improve the focusing accuracy of the adjustable focus lens group 3, see Figure 2 As shown, the light guide component 2 may include an optical fiber bundle 21 and a collimator 22 disposed at the output end of the optical fiber bundle.

[0046] The focusable lens group 3 can be any component that can achieve focusing. By setting the focusable lens group 3 at the output end of the light guide component 2, the focal length of the therapeutic light emitted from the light guide component 2 can be changed, thereby achieving adjustment of the divergence angle of the therapeutic light.

[0047] Exemplarily, the adjustable focus lens group 3 may be a lens group that realizes the focusing function by controlling the movement of the lens along the optical axis through an electrical signal. Alternatively, in order to simplify the structural design, avoid increasing the size of the head end, and improve the focusing reliability, the adjustable focus lens group 3 provided in the embodiment of the present invention may also include but is not limited to a lens group that changes its own optical characteristics under the control of an electrical signal, such as a deformable lens or a refractive index adjustable lens.

[0048] Among them, the deformable lens refers to a lens that changes the curvature of the optical surface under the control of an electrical signal, and may include but is not limited to a piezoelectrically actuated deformable lens, a liquid lens, a liquid crystal adaptive lens, etc. Among them, since the processes of piezoelectrically actuated deformable lenses and liquid lenses are relatively mature and have better performance, they are used as the adjustable focus lens group 3 in this application, which can improve the response speed and further improve the treatment efficiency. The refractive index adjustable lens specifically realizes the focusing effect by controlling the properties of some special materials to achieve the change of the refractive index. The common control method is to change the optical properties of the liquid crystal material by applying an electric field. When a positive electric field is applied to the liquid crystal material, the liquid crystal molecules are rearranged parallel to the direction of the electric field, and the refractive index decreases. When a reverse electric field is applied, the liquid crystal molecules deviate from the original arrangement direction and are perpendicular to the direction of the electric field, and the refractive index increases.

[0049] Furthermore, the present application does not limit the type of control signal, which is determined according to actual conditions. For example, in the lens assembly described above, which realizes the focusing function by controlling the lens to move along the optical axis through an electrical signal, the control signal is an electrical signal used to characterize the control of the movement of the lens along the optical axis; in the case of a lens with adjustable refractive index, the control signal is a signal used to characterize the control of the properties of some special materials. Similarly, the size of the control signal is not limited, and is usually given by the controller 4.

[0050] Taking the focus-adjustable lens group as a deformable lens as an example, Figure 2 A schematic diagram of a variation of the divergence angle of a therapeutic light provided by an embodiment of the present invention, for the therapeutic light emitted by the light source 1, Figure 2 In the embodiment, the therapeutic light sequentially passes through the optical fiber bundle 21 of the light guide component 2, the collimator 22 disposed at the output end of the optical fiber bundle 21, and the deformable lens 31 to be emitted to the irradiation surface 5. The light beam emitted by the optical fiber bundle 21 is transmitted to the deformable lens 31 through the collimator 22, and after passing through the deformable lens 31, the light beam is irradiated to the irradiation surface 5 at a certain divergence angle.

[0051] The controller 4 is connected to the light source 1 and the focusable lens group 3 respectively, and is configured to drive the focusable lens group 3 according to the received signal containing the target divergence angle, so that the therapeutic light is emitted according to the target divergence angle.

[0052] by Figure 2 Taking the two divergence angles given as examples, assuming that the driving signal is 1, the corresponding divergence angle is β; assuming that the driving signal is 2, the corresponding divergence angle is γ, the size of the light spot corresponding to the divergence angle β is not equal to the size of the light spot corresponding to the divergence angle γ. It can be seen that due to the change of the driving signal of the deformable lens 31, the focal length of the deformable lens 31 changes, and then the divergence angle of the light beam after passing through the deformable lens 31 changes. Finally, even if the irradiation distance is not changed, the size of the light spot irradiated on the irradiation surface also changes.

[0053] When the controller 4 drives the focusable lens group 3 according to the received signal containing the target divergence angle, it can pre-establish and store the mapping relationship between the divergence angle and the driving signal, and determine the target driving signal corresponding to the target divergence angle according to the mapping relationship between the divergence angle and the driving signal. After obtaining the target driving signal and applying the target driving signal to the focusable lens group 3, the therapeutic light is emitted according to the target divergence angle.

[0054] Compared to the method of calculating the target drive signal corresponding to the target divergence angle after determining the target divergence angle, the method provided in this embodiment determines the target drive signal corresponding to the target divergence angle through a pre-established mapping relationship after obtaining the target divergence angle. Since the mapping relationship table is directly called, the target drive signal corresponding to the target divergence angle can be quickly obtained, and a quick response is achieved.

[0055] Furthermore, in this embodiment, the controller 4 is also configured to: adjust the energy output value of the light source according to the target divergence angle.

[0056] It is understandable that the total energy of the therapeutic light emitted by the photodynamic therapy device is determined by the energy output value of the light source 1. Therefore, when the energy output value of the light source 1 is constant, the total energy of the emitted therapeutic light is also basically constant. However, when the therapeutic light is irradiated to the irradiation surface 5 at different divergence angles, the corresponding therapeutic light spots are of different sizes. Therefore, when the energy output value of the light source 1 is constant, the energy per unit area of ​​the therapeutic light spots corresponding to different divergence angles is different. In particular, when the divergence angle of the therapeutic light is large, the therapeutic light spot formed on the irradiation surface is large, and its energy per unit area is relatively reduced, and it may be necessary to extend the treatment time to achieve the expected therapeutic effect.

[0057] Therefore, this embodiment configures the controller to adjust the energy output value of the light source according to the target divergence angle, and can synchronously adapt to the size of the treatment spot to adjust the energy, ensuring that the energy per unit area of ​​the treatment spot meets the intensity requirement, thereby further improving the treatment efficiency.

[0058] Furthermore, in order to ensure the safety of photodynamic therapy and avoid accidental burning of normal tissues in the cavity, the working state of the photodynamic therapy device in this embodiment includes an initial startup state and a treatment state, wherein the initial startup state refers to a state in which the light source 1 is started but the photodynamic therapy has not yet been performed; and the treatment state refers to a state in which the photodynamic therapy is performed.

[0059] Specifically, in the initial startup state, the controller 4 is also configured as follows:

[0060] The energy output value of the light source 1 is controlled to be less than or equal to a preset threshold value, and / or the focus-adjustable lens group is driven to make the therapeutic light emit at a minimum divergence angle.

[0061] The preset threshold value may be any non-zero energy value that can avoid damaging normal tissue. For example, the preset threshold value may be set to an energy value that enables the therapeutic light to be captured by the imaging device and displayed in the image, but can avoid damaging normal tissue. In this way, it is convenient for doctors to determine the irradiation position of the therapeutic light before performing photodynamic therapy without damaging normal tissue, thereby improving the safety of the operation and reducing the difficulty of the operation.

[0062] In addition, this embodiment does not limit the minimum divergence angle. Generally, the minimum divergence angle can be set according to the minimum size of common lesions. Generally, before starting the light source 1 to emit therapeutic light, the doctor usually aligns the therapeutic light emission end roughly with the target area (i.e., the area where photodynamic therapy is required), but the alignment accuracy is low. By emitting the therapeutic light at the minimum divergence angle in the initial startup state, the irradiation range of the therapeutic light can be reduced, so that the therapeutic light spot falls entirely within the target area, thereby avoiding accidental burns to normal tissues and improving the safety of the treatment process.

[0063] In summary, the photodynamic therapy device provided by the present invention can make the therapeutic light emit at any given divergence angle (i.e., the target divergence angle) by setting an adjustable focus lens group driven by a controller at the emission end of the light-guiding component. Among them, since the size of the therapeutic spot irradiated on the irradiation surface (e.g., the surface where the tumor tissue site is located) is positively correlated with the irradiation distance and the divergence angle of the therapeutic light, the photodynamic therapy device provided by the present invention can achieve adaptive adjustment of the size of the therapeutic spot irradiated on the irradiation surface by adjusting the divergence angle of the emitted therapeutic light through the adjustable focus lens group. Therefore, when the photodynamic therapy device provided by the present invention is used to perform photodynamic therapy on the target area (e.g., the tumor tissue site), the divergence angle of the therapeutic light can be adaptively adjusted according to the size of the target area, so that the therapeutic spot can just cover the target area. During this period, there is no need to repeatedly adjust the distance between the therapeutic light emission end and the target area (i.e., the irradiation distance), which simplifies the photodynamic therapy operation process, reduces the doctor's operating burden, and improves the treatment efficiency.

[0064] A photodynamic therapy device is described above, and this embodiment also provides an endoscope system. Figure 3 A schematic diagram of an endoscope system provided by an embodiment of the present invention is shown in FIG. Figure 3 As shown, the endoscope system includes: an imaging device 6, a processor 7 and a photodynamic therapy device 8 described in any of the above embodiments, the processor 7 is respectively connected to the imaging device 6 and the controller 4 in the photodynamic therapy device 8, wherein:

[0065] An imaging device 6, configured to capture a real-time image of a subject;

[0066] The processor 7 is configured to identify the target area in the real-time image, calculate the target divergence angle that matches the target area, and send a signal containing the target divergence angle to the controller 4, so that the controller 4 drives the focusable lens group 3 according to the signal containing the target divergence angle, thereby causing the therapeutic light to be emitted according to the target divergence angle.

[0067] The photodynamic therapy device 8 includes the light source 1 described above, which is used to provide therapeutic light; a light guide component 2, whose incident end is coupled to the light source 1, and is used to derive the therapeutic light; an adjustable focus lens group 3, which is arranged at the output end of the light guide component 2, and is used to adjust the divergence angle of the therapeutic light emitted from the light guide component 2 according to a control signal; a controller 4, which is respectively connected to the light source 1 and the adjustable focus lens group 3, and is configured to drive the adjustable focus lens group 3 according to a received signal containing a target divergence angle, so that the therapeutic light is emitted according to the target divergence angle.

[0068] The imaging device 6 includes an image sensor. A real-time image of the subject is obtained based on the light signal collected by the image sensor. In practice, there may be no target area in the image collected by the imaging device (the target area in the embodiment of the present invention refers to the area where photodynamic therapy is required, such as the area where lesions, tumors, etc. exist), or there may be other areas in addition to the target area (the other areas refer to non-target areas). In order to enable the therapeutic light to completely cover the target area, it is necessary to first accurately determine the target area. Therefore, after the processor obtains the image collected by the imaging device 6, it is necessary to further process the image and extract the target area from the image. The target area can be manually marked by the user or obtained by feature extraction of the image. There is no limitation on this, as long as the target area can be determined. After determining the target area, the target divergence angle that matches the target area is calculated based on the target area. Specifically, calculating the target divergence angle that matches the target area includes:

[0069] The target divergence angle adapted to the target area is calculated according to the prior parameters of the imaging device 6 and the size information of the target area in the real-time image. The prior parameters of the imaging device 6 include the imaging field angle, focal length, and image diagonal width; the size information of the target area in the real-time image includes the minimum circumscribed circle diameter of the target area.

[0070] When the processor 7 calculates the target divergence angle adapted to the target area, the target divergence angle of the therapeutic light to be emitted can be determined according to the proportion of the target area in the real-time image and the field of view of the lens.

[0071] Specifically, the processor 7 extracts each edge point of the target area from the real-time image; obtains the maximum distance value from the center point of the target area to each edge point; determines the circumscribed circle of the target area with the maximum distance value as the radius; and determines the target divergence angle of the therapeutic light to be emitted according to the ratio of the diameter of the circumscribed circle to the diagonal width of the real-time image and the diagonal field of view of the lens.

[0072] After obtaining the target divergence angle, the processor 7 transmits the information including the target divergence angle to the controller 4 via serial communication. The controller 4 drives the focusable lens group according to the signal including the target divergence angle, thereby emitting the therapeutic light according to the target divergence angle.

[0073] Furthermore, considering that in the specific implementation process, after the target divergence angle is calculated, the doctor may not be ready to perform photodynamic therapy on the target area at this time. If the photodynamic therapy device 8 is directly controlled to emit therapeutic light, normal tissue may be accidentally burned.

[0074] Therefore, in some embodiments, the processor 7 is configured to: send the target divergence angle to the controller 4 in response to executing the treatment instruction; or the controller 4 is configured to:

[0075] In response to the execution of the treatment instruction, the focus-adjustable lens group 3 is driven according to the received target divergence angle signal, so that the treatment light is emitted according to the target divergence angle.

[0076] The treatment instruction in this embodiment can be manually triggered by a doctor, or automatically triggered by the processor 7 or the controller 4 under certain circumstances. Depending on the terminal receiving the treatment instruction, the specific implementation method may include:

[0077] 1. The processor 7 receives a treatment instruction, and after receiving the instruction, sends a signal containing a target divergence angle. After receiving the signal containing the target divergence angle, the controller 4 can directly adjust the driving signal of the adjustable focus lens group 3;

[0078] 2. The controller 4 receives and executes the treatment instruction, and then the processor 7 sends the target divergence angle to the controller 4 as long as it calculates it.

[0079] Specifically, as an example of automatically triggering a treatment instruction by the processor 7 under specific circumstances, in this embodiment, the processor 7 is also configured to automatically trigger the execution of the treatment instruction when it is detected that the center of the spot of the treatment light overlaps with the center of the target area.

[0080] It is understandable that since the treatment spot is usually roughly circular, when its center is fixed, adjusting the divergence angle of the emitted treatment light is equivalent to adjusting the diameter of the treatment spot. Therefore, when the center of the treatment light spot overlaps with the center of the target area, it can be considered that the doctor has adjusted the position of the treatment light emission end and is ready for photodynamic therapy. At this time, the automatic triggering instruction treatment instruction can eliminate the need for the doctor to perform triggering operations such as pressing buttons and clicking the screen, further improving the convenience of photodynamic therapy operation and improving treatment efficiency.

[0081] In order to make those skilled in the art better understand the present invention, Figure 4 The present invention is further described in detail with specific implementation modes. Figure 4 A structural diagram of an endoscope system provided by an embodiment of the present invention, such as Figure 4 As shown, the endoscope system mainly consists of two parts, the first part is the endoscope imaging system, and the second part is the photodynamic therapy device 8.

[0082] The endoscope imaging system includes an endoscope body insertion part 9 and an image processor 71. A complementary metal oxide semiconductor (CMOS) image sensor, i.e., a CMOS image sensor 61, is disposed at the distal end of the endoscope body insertion part 9. Specifically, the image processor 71 includes an imaging part, a lesion area extraction part, and a divergence angle calculation part; and the CMOS image sensor 61 is connected to the imaging part.

[0083] The controller 4 in the photodynamic therapy device 8 includes a driving information calculation unit, a deformable lens control circuit, and a light source control unit. The light source control unit generates a therapeutic light source. The deformable lens control circuit is connected to the deformable lens 31 through a wire. After the driving signal changes, the divergence angle of the therapeutic light source emitted from the deformable lens 31 can emit a light beam at a divergence angle corresponding to the driving signal, and irradiate the irradiation surface 5.

[0084] It should be noted that after obtaining the target driving signal, the deformable lens control circuit compares the current driving signal with the target driving signal. If they are the same, there is no need to change the current driving signal; if they are not the same, the current driving signal is adjusted to the target driving signal.

[0085] Optionally, the light-guiding component 2 and the deformable lens 31 in the photodynamic therapy device 8 can be inserted into the instrument channel in the endoscope body insertion portion 9 and extend from the instrument channel opening at the distal end.

[0086] Alternatively, the light guide component 2 and the deformable lens 31 in the photodynamic therapy device 8 can also be integrated into the endoscope body insertion part 9. In this embodiment, if the position of the deformable lens 31 in the endoscope body insertion part 9 is far away from the target area, the surface of the endoscope body will affect the light beam and cannot be emitted at the target divergence angle, and the light energy reaching the target area will be reduced. If the target area is a lesion, the energy irradiated on the lesion will be reduced, and the target area cannot be effectively treated. Therefore, in this embodiment, the side of the light beam passing through the deformable lens 31 that is closest to the target area coincides with the side of the endoscope body insertion part 9 that is close to the target area.

[0087] The photodynamic therapy device 8 is serially connected to the CMOS image processor 71, that is, the divergence angle calculation unit is serially connected to the drive information calculation unit. The CMOS image sensor 61 obtains a real-time image including the lesion site and transmits it to the image processor 71 to extract the lesion area. The divergence angle calculation unit calculates the target divergence angle according to the lesion area ratio in pixel space and the imaging field angle. The information containing the target divergence angle is transmitted to the drive information calculation unit of the photodynamic therapy device 8 via serial communication. The drive information calculation unit calculates the drive information corresponding to the target divergence angle based on the mapping relationship between the divergence angle and the drive information. Finally, the control circuit drives the deformable lens 31 to deform so that the therapeutic light is irradiated to the target area at the target divergence angle. Figure 2 According to the principle of change in the divergence angle of therapeutic light in the adaptive photodynamic device, the deformable lens control circuit drives the deformable lens 31 to change its curvature, resulting in a change in the divergence angle of the light beam emitted from the deformable lens 31, thereby changing the size of the therapeutic light spot.

[0088] In order to make those skilled in the art better understand the present invention, Figure 5 and described above Figure 4 The present invention is further described in detail with specific implementation modes.

[0089] use Figure 4 The workflow of photodynamic therapy performed by the endoscopic system shown is as follows:

[0090] (1) After finding the lesion site under endoscopic observation, the light-guiding component of the photodynamic therapy device is inserted into the body cavity through the instrument channel in the insertion portion 9 of the endoscope body. The therapeutic light source is adjusted manually or by the light source processor to a lower gear and adjusted to the minimum divergence angle. The light-guiding component irradiates the therapeutic light with the smallest light spot. The front end position of the endoscope body is adjusted so that the center of the light spot is exactly at the center of the lesion.

[0091] (2) The endoscope is switched to fluorescence imaging mode. The tumor tissue emits fluorescence under the irradiation of fluorescence excitation light. The image sensor obtains the fluorescence image of the lesion and selects the area where the lesion is located (i.e., the target area) based on the fluorescence image.

[0092] (3) Turn on the automatic adjustment of the divergence angle function. The image processor calculates the divergence angle based on the currently captured fluorescence image. The method for calculating the divergence angle is as follows: Figure 5 As shown, Figure 5 A schematic diagram of calculating the divergence angle of therapeutic light provided by an embodiment of the present invention, Figure 5 Where α is the diagonal field of view of the lens, W is the diagonal width of the image, f is the focal length, θ is the divergence angle of the treatment light, and D is the minimum circumscribed circle diameter of the lesion edge. The lesion area extraction unit extracts the edge of the tumor tissue, calculates the center point, and takes the maximum distance from the center point to the edge point as the radius to obtain the minimum circumscribed circle of the edge. The divergence angle of the treatment light can be calculated based on the known diagonal field of view.

[0093] (4) After the light source processor of the photodynamic therapy device receives the information containing the target divergence angle transmitted by the divergence angle calculation unit of the image processor, it calculates the driving information of the corresponding deformable lens, controls the curvature change of the deformable lens to achieve the target divergence angle, and adjusts the treatment light to the appropriate gear (i.e., increases the current value) to start photodynamic therapy.

[0094] Among them, it is understandable that the above Figure 4 The description of the workflow of the endoscope system for photodynamic therapy is only an exemplary description and is not intended to limit the present invention. For example, in some other embodiments, the auxiliary diagnosis device can also be used to directly determine the target area in the current imaging mode without switching the imaging mode.

[0095] The endoscope system provided in the embodiment of the present invention can adaptively adjust the divergence angle of the therapeutic light according to the size of the target area, so that the therapeutic light spot can just cover the target area. During this period, there is no need to repeatedly adjust the distance between the therapeutic light output end and the target area (i.e., the irradiation distance), which simplifies the photodynamic therapy operation process, reduces the doctor's operating burden, and improves the treatment efficiency.

[0096] The above is a detailed introduction to a photodynamic therapy device and an endoscope system provided by the present invention. The various embodiments in the specification are described in a progressive manner, and each embodiment focuses on the differences from other embodiments. The same and similar parts between the embodiments can be referenced to each other. For the device disclosed in the embodiment, since it corresponds to the method disclosed in the embodiment, the description is relatively simple, and the relevant parts can be referred to the method part description. It should be pointed out that for ordinary technicians in this technical field, without departing from the principle of the present invention, several improvements and modifications can be made to the present invention, and these improvements and modifications also fall within the scope of protection of the claims of the present invention.

[0097] It should also be noted that, in this specification, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "comprise", "include" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, an element defined by the statement "comprises a ..." does not exclude the presence of other identical elements in the process, method, article or device including the element.

Claims

1. A photodynamic therapy device, characterized in that: include: A light source (1) for providing therapeutic light; A light guide component (2), the incident end of which is coupled to the light source (1) and is used to guide the therapeutic light; A focusable lens group (3) is arranged at the emission end of the light guide component (2) and is used to adjust the divergence angle of the therapeutic light emitted from the light guide component (2) according to a control signal; A controller (4) is connected to the light source (1) and the focusable lens group (3) respectively, and is configured to drive the focusable lens group (3) according to a received signal containing a target divergence angle, so that the therapeutic light is emitted according to the target divergence angle.

2. The photodynamic therapy device according to claim 1, characterized in that: The adjustable focus lens group (3) comprises a deformable lens or a refractive index adjustable lens.

3. The photodynamic therapy device according to claim 2, characterized in that: The deformable lens is a piezoelectrically actuated deformable lens or a liquid lens.

4. The photodynamic therapy device according to claim 1, characterized in that: The light-guiding component (2) comprises an optical fiber bundle (21) and a collimator (22) arranged at the output end of the optical fiber bundle (21).

5. The photodynamic therapy device according to claim 1, characterized in that: The controller (4) is also configured to: The energy output value of the light source (1) is adjusted according to the target divergence angle.

6. The photodynamic therapy device according to any one of claims 1 to 5, characterized in that: In the initial startup state, the controller (4) is also configured to: The energy output value of the light source (1) is controlled to be less than or equal to a preset threshold value, and / or the focusable lens group (3) is driven so that the therapeutic light is emitted at a minimum divergence angle.

7. An endoscope system, characterized in that: include: An imaging device (6), a processor (7), and a photodynamic therapy device (8) according to any one of claims 1 to 6, wherein the processor (7) is communicatively connected to the imaging device (6) and a controller in the photodynamic therapy device, respectively, wherein: The imaging device (6) is configured to capture a real-time image of the subject; The processor (7) is configured to identify a target area in the real-time image, calculate a target divergence angle that matches the target area, and send a signal containing the target divergence angle to the controller (4), so that the controller (4) drives the focusable lens group (3) according to the signal containing the target divergence angle, thereby causing the therapeutic light to be emitted according to the target divergence angle.

8. The endoscope system according to claim 7, characterized in that: The calculating of the target divergence angle adapted to the target area comprises: The target divergence angle matched with the target area is calculated based on the prior parameters of the imaging device (6) and the size information of the target area in the real-time image.

9. The endoscope system according to claim 7, characterized in that: The processor (7) is configured to: in response to executing a treatment instruction, send a signal containing the target divergence angle to the controller; or, The controller (4) is configured to: In response to executing a treatment instruction, the focus-adjustable lens group (3) is driven according to a received signal containing the target divergence angle, so that the treatment light is emitted according to the target divergence angle.

10. The endoscope system according to claim 9, characterized in that: The processor (7) is also configured to automatically trigger the execution of the treatment instruction when it is detected that the center of the spot of the treatment light overlaps with the center of the target area.

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