Powder mixing device and method for diclofenac sodium enteric-coated tablet preparation process

Abstract

The invention relates to a powder mixing device and method for a diclofenac sodium enteric-coated tablet preparation process. The powder mixing device for the diclofenac sodium enteric-coated tablet preparation process comprises an outer cylinder, a powder mixing device and a powder mixing device, the top of the outer cylinder is provided with a feed hopper, and the bottom of the outer cylinder is provided with a plurality of discharge ports; the inner cylinder is arranged on the inner side of the outer cylinder, a rotating shaft is arranged in the middle of the inner cylinder, and the rotating shaft is connected with a cylinder body of the inner cylinder; the driving device is connected with the rotating shaft; the upper end of the circulating pipe is connected with the feeding hopper of the outer cylinder, and the lower end of the circulating pipe is connected with the discharging opening of the outer cylinder; and at least one vacuum pump, wherein each vacuum pump is connected with one circulating pipe. Compared with the prior art, the fluidity of powder can be improved, and the powder can be mixed more uniformly.

Description

Technical Field

[0001] The invention relates to the technical field of powder mixing, and in particular to a powder mixing device and method for preparing diclofenac sodium enteric-coated tablets. Background Art

[0002] Diclofenac sodium enteric-coated tablets have the effect of relieving fever and relieving pain. The main ingredient of the drug is diclofenac sodium, which is a non-steroidal anti-inflammatory drug. After taking the drug, it can reduce the activity of cyclooxygenase in the body and reduce the amount of prostaglandin synthesis, thereby relieving pain. In addition, it can also reduce the level of anti-leukotrienes in the body and have an anti-inflammatory effect. Diclofenac sodium enteric-coated tablets are often used to treat muscle and bone pain caused by diseases such as rheumatoid arthritis, cervical spondylosis, frozen shoulder, and osteoarthritis.

[0003] The preparation of diclofenac sodium enteric-coated tablets generally includes the following steps: first, mixing the raw materials and auxiliary materials, then wet granulating, drying and dry granulating, then adding additional auxiliary materials and mixing, and finally tableting. Among them, the effect of mixing the raw materials and auxiliary materials directly affects the efficacy of the drug. The existing mixing device generally sets a mechanical stirring unit in the mixing barrel. The powder is mixed by mechanical stirring alone, and the fluidity of the powder is poor and the mixing uniformity is low. Summary of the invention

[0004] Based on this, the purpose of the present invention is to overcome the shortcomings and deficiencies in the prior art and provide a powder mixing device and method for the preparation process of diclofenac sodium enteric-coated tablets.

[0005] In a first aspect, the present invention provides a powder mixing device for use in a preparation process of diclofenac sodium enteric-coated tablets, comprising: An outer cylinder, wherein a feed hopper is provided at the top of the outer cylinder and a plurality of discharge ports are provided at the bottom of the outer cylinder; An inner cylinder, wherein the inner cylinder is arranged on the inner side of the outer cylinder, a rotating shaft is arranged in the middle of the inner cylinder, and the rotating shaft is connected to the cylinder body of the inner cylinder; A driving device connected to the rotating shaft; At least one circulation pipe, the upper end of which is connected to the feed hopper of the outer barrel, and the lower end of which is connected to the discharge port of the outer barrel; At least one vacuum pump, each of the vacuum pumps is connected to one of the circulation pipes.

[0006] In one embodiment, the inner cylinder includes a premixing device, which is connected to the feed hopper of the outer cylinder and is used for preliminarily mixing the powder.

[0007] In one embodiment, the premixing device is an upwardly convex arc-shaped structure, and the concave end of the premixing device is fixed to the top end of the rotating shaft.

[0008] In one of the embodiments, a heating wire is provided at the bottom of the premixing device.

[0009] In one embodiment, the upper portion of the inner cylinder is open, and the top end of the rotating shaft is located outside the inner cylinder.

[0010] In one of the embodiments, the outer cylinder includes a flow guide device, which is a truncated cone structure with upper and lower openings, a top radius of the flow guide device being larger than a bottom radius, and a side wall of the flow guide device extending downward from an inner wall of the outer cylinder and passing through a gap between the premixing device and the top end of the inner cylinder.

[0011] In one of the embodiments, a plurality of circumferentially distributed stirring blades are provided on the upper portion of the inner wall of the inner cylinder.

[0012] In one of the embodiments, a plurality of through holes are provided in the circumferential direction of the lower portion of the side wall of the inner cylinder.

[0013] In one of the embodiments, a discharge port is provided at the bottom of the outer cylinder.

[0014] In a second aspect, the present invention provides a powder mixing method for preparing diclofenac sodium enteric-coated tablets, using a powder mixing device for preparing diclofenac sodium enteric-coated tablets as described above, comprising the following steps: (1) Powder is put into the inner cylinder for mixing; (2) The vacuum pump is started, and the circulation pipe returns the mixed powder to the inner cylinder for remixing.

[0015] In one embodiment, step (1) includes: the powder first falls onto the premixing device for preliminary mixing; while the powder moves from top to bottom in the inner cylinder, the stirring blades and the cylinder body of the inner cylinder stir and mix the powder; and under the action of centrifugal force, the mixed powder enters the cavity between the outer cylinder and the inner cylinder through the through hole.

[0016] In one embodiment, step (1) includes: the powder first falls onto the premixing device for heating and preliminary mixing.

[0017] When the powder mixing device of the preparation process of diclofenac sodium enteric-coated tablets of the present invention is used for mixing, the powder first falls on the premixing device, and the arc-shaped structure of the premixing device can disperse the powder. At the same time, due to the rotation of the premixing device, the powder can be preliminarily mixed and then enter the inner cylinder. In the process of the powder moving from top to bottom inside the inner cylinder, the rotating stirring blades and the cylinder body of the inner cylinder can stir and mix the powder. After the powder moves to the lower part of the inner cylinder, under the centrifugal force of the rotation of the inner cylinder, it enters the cavity between the outer cylinder and the inner cylinder through the through hole at the lower part of the side wall of the inner cylinder. The circulation unit can lift the mixed powder in the cavity from the discharge port of the outer cylinder to the feed hopper of the outer cylinder, and then enter the inner cylinder for mixing again. Compared with the prior art, the present invention utilizes the combination of multiple technical means such as the rotation of the inner cylinder, stirring blades, premixing device, circulation unit, etc. to improve the fluidity of the powder and make the powder mixing more uniform. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 The present invention is a schematic diagram of the structure of a powder mixing device used in the preparation process of diclofenac sodium enteric-coated tablets.

[0019] The markings in the figure are: 10—outer cylinder; 102—feed hopper; 104—discharge port; 106—discharge port; 108—flow guide device; 12—inner cylinder; 122—stirring blades; 124—through hole; 126—rotating shaft; 128—premixing device; 14—driving device; 20—circulation pipe; 22—vacuum pump. DETAILED DESCRIPTION

[0020] In order to make the above-mentioned purposes, features and advantages of the present application more obvious and easy to understand, the specific implementation methods of the present application are described in detail below in conjunction with the accompanying drawings. In the following description, many specific details are set forth to facilitate a full understanding of the present application. However, the present application can be implemented in many other ways different from those described herein, and those skilled in the art can make similar improvements without violating the connotation of the present application, so the present application is not limited by the specific embodiments disclosed below.

[0021] In the description of the present application, it should be understood that if the terms "center", "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc. appear, the orientation or position relationship indicated by these terms is based on the orientation or position relationship shown in the accompanying drawings, which is only for the convenience of describing the present application and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present application.

[0022] In addition, the terms "first", "second", "third", and "fourth" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one of the features. In the description of this application, the term "plurality" means at least two, such as two, three, etc., unless otherwise clearly and specifically defined.

[0023] In this application, unless otherwise clearly specified and limited, if the terms "installed", "connected", "connected", "fixed" and the like appear, these terms should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integrated connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements, unless otherwise clearly defined. For ordinary technicians in this field, the specific meanings of the above terms in this application can be understood according to the specific circumstances.

[0024] In the present application, unless otherwise clearly specified and limited, if there is a description that a first feature is "above" or "below" a second feature, etc., or similar descriptions appear, it may mean that the first and second features are in direct contact, or that the first and second features are in indirect contact through an intermediate medium. Moreover, the first feature being "above", "above" and "above" the second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the first feature is higher in level than the second feature. The first feature being "below", "below" and "below" the second feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the first feature is lower in level than the second feature.

[0025] The technical solution of the present invention is described in detail below with reference to specific embodiments.

[0026] See also Figure 1 The powder mixing device for the preparation process of diclofenac sodium enteric-coated tablets of the present invention comprises a mixing unit and a circulation unit. The mixing unit is used for mixing powders, and comprises an outer cylinder 10, an inner cylinder 12 and a driving device 14. The inner cylinder 12 is located inside the outer cylinder 10 and is rotatably connected to the outer cylinder 10. The driving device 14 is fixedly connected to the inner cylinder 12 and is used to drive the inner cylinder 12 to rotate. The circulation unit is connected to the mixing unit and is used to put the powder mixed in the mixing unit into the mixing unit again for mixing, so as to improve the mixing effect.

[0027] Specifically, a feed hopper 102 is provided at the top of the outer cylinder 10, and a top cover is provided at the feed port of the feed hopper 102. The bottom of the feed hopper 102 is connected to the inside of the cylinder body of the outer cylinder 10, and the powder to be mixed can enter the outer cylinder through the feed hopper 102. A plurality of discharge ports 104 are provided at the bottom of the outer cylinder 10, and the mixed powder can enter the circulation unit through the discharge ports 104. A discharge port 106 is also provided at the bottom of the outer cylinder 10, and the mixed powder can enter the next process through the discharge port 106.

[0028] The inner cylinder 12 is vertically coaxially arranged inside the outer cylinder 10, and there is a gap between the inner cylinder 12 and the outer cylinder 10 in the radial direction. The upper part of the inner cylinder 12 is open, and its opening corresponds to the bottom of the feed hopper 102 at the top of the outer cylinder 10. Therefore, the powder to be mixed can enter the inner cylinder 12 through the feed hopper 102 for mixing. The upper part of the inner wall of the inner cylinder 12 is provided with a plurality of circumferentially distributed stirring blades 122, and the lower part of the side wall is circumferentially provided with a plurality of through holes 124. A rotating shaft 126 is provided in the middle part of the inner cylinder 12, and the rotating shaft 126 passes through the bottom of the inner cylinder 12 and the outer cylinder 10 respectively, and extends to the outside of the outer cylinder 10.

[0029] The driving device 14 includes a motor, a driving gear and a driven gear. The driving shaft of the motor is coaxially connected to the driving gear, and the driven gear is meshed with the driving gear. The bottom end of the rotating shaft 126 of the inner cylinder 12 is meshed with the driven gear. Therefore, when the motor is started, the inner cylinder 12 can be driven to rotate. After the powder to be mixed enters the inner cylinder 12, the rotating stirring blades 122 stir and mix the powder during the top-down movement, and the rotation of the inner cylinder 12 also stirs and mixes the powder. Due to the rotation of the inner cylinder 12, the mixed powder enters the cavity between the outer cylinder 10 and the inner cylinder 12 through the through hole 124 under the action of centrifugal force.

[0030] In order to achieve a better mixing effect, the inner cylinder 12 of the present invention further includes a premixing device 128, which is an arc-shaped structure convex upward, and the concave end of the premixing device 128 is fixed to the top of the rotating shaft 126. Therefore, the premixing device 128 can rotate with the rotating shaft 126. Further, the outer cylinder 10 of the present invention further includes a flow guide device 108, which is a truncated cone structure with upper and lower openings, the top surface radius of the flow guide device 108 is larger than the bottom surface radius, and the side wall of the flow guide device 108 extends downward from the inner wall of the outer cylinder 10 and passes through the gap between the premixing device 128 and the top of the inner cylinder 12. The powder to be mixed falls onto the premixing device 128 through the feed hopper 102 of the outer cylinder 10. The arc-shaped structure of the premixing device 128 can disperse the powder. At the same time, due to the rotation of the premixing device 128, the powder can be preliminarily mixed and fall onto the inner wall of the guide device 108, and then enter the interior of the inner cylinder 12.

[0031] Preferably, a heating wire is also provided at the bottom of the premixing device 128. This is mainly because the powder is not easy to disperse when it is damp, which will affect the mixing effect. The setting of the heating wire of the present invention can heat the powder, making the powder easier to disperse and the mixing effect better.

[0032] The circulation unit includes a plurality of circulation pipes 20 and a vacuum pump 22, and each circulation pipe 20 is connected to a vacuum pump 22. The upper end of the circulation pipe 20 is connected to the feed hopper 102 of the outer cylinder 10, and the lower end is connected to the discharge port 104 of the outer cylinder 10. After the vacuum pump 22 is started, the pressure inside the circulation pipe 20 is reduced, and the powder mixed in the cavity between the outer cylinder 10 and the inner cylinder 12 can move along the circulation pipe 20 toward the feed hopper 102 through the discharge port 104, and then enter the inner cylinder 12 for re-mixing.

[0033] On the one hand, the provision of the circulation unit increases the flow of the powder. On the other hand, when the powder enters the mixing unit again, it can increase the gas flow in the mixing unit, impacting the powder in the mixing unit, thereby improving the fluidity of the powder in the mixing unit. Therefore, the provision of the circulation unit of the present invention can improve the fluidity of the powder and make the powder mixing more uniform.

[0034] This embodiment 1 also provides a method for mixing powders using the above device, including: (1) Put the powder into the inner cylinder for mixing.

[0035] Specifically, the motor is started, and the rotating shaft 126 drives the cylinder body, the stirring blades 122 and the premixing device 128 of the inner cylinder 12 to rotate; the powder is fed into the feed hopper 102, and the powder first falls on the premixing device 128. The arc-shaped structure of the premixing device 128 can disperse the powder. At the same time, due to the rotation of the premixing device 128, the powder is preliminarily mixed and then falls on the guide device 108, and then enters the interior of the inner cylinder 12.

[0036] When the powder moves from top to bottom in the inner cylinder 12, the rotating stirring blades 122 stir and mix the powder, and the rotation of the inner cylinder 12 also stirs and mixes the powder. After the powder is mixed in the inner cylinder 12, due to the rotation of the inner cylinder 12, the mixed powder enters the cavity between the outer cylinder 10 and the inner cylinder 12 through the through hole 124 under the action of centrifugal force.

[0037] (2) The vacuum pump is started, and the circulation pipe returns the mixed powder to the inner cylinder for remixing.

[0038] At this time, the powder mixed by the inner cylinder 12 exists in the cavity between the outer cylinder 10 and the inner cylinder 12. The vacuum pump 22 is started, and the circulation pipe 20 lifts the mixed powder from the discharge port 104 of the outer cylinder to the feed hopper 102 of the outer cylinder 10. Thus, the mixed powder can enter the inner cylinder 12 again for re-mixing.

[0039] The present invention can have a variety of modified implementations, such as the circulation pipe 20 is connected to the discharge pipe through a one-way valve, so that the mixed powder can enter the next process through the circulation pipe 20. In addition, the present invention can also be provided with a control device to control the number of powder mixing or total mixing time and other parameters to achieve the desired mixing effect.

[0040] Compared with the prior art, the present invention utilizes a combination of multiple technical means such as the rotation of the inner cylinder, stirring blades, a premixing device, a circulation unit, etc. to improve the fluidity of the powder and make the powder mixing more uniform.

[0041] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0042] The above-described embodiments only express several implementation methods of the present application, and the descriptions thereof are relatively specific and detailed, but they cannot be construed as limiting the scope of the patent application. It should be pointed out that, for a person of ordinary skill in the art, several variations and improvements can be made without departing from the concept of the present application, and these all belong to the protection scope of the present application. Therefore, the protection scope of the patent application shall be subject to the attached claims.

Claims

1. A powder mixing device for the preparation process of diclofenac sodium enteric-coated tablets, characterized in that: include: An outer cylinder, wherein a feed hopper is provided at the top of the outer cylinder and a plurality of discharge ports are provided at the bottom of the outer cylinder; An inner cylinder, wherein the inner cylinder is arranged on the inner side of the outer cylinder, a rotating shaft is arranged in the middle of the inner cylinder, and the rotating shaft is connected to the cylinder body of the inner cylinder; A driving device connected to the rotating shaft; At least one circulation pipe, the upper end of which is connected to the feed hopper of the outer barrel, and the lower end of which is connected to the discharge port of the outer barrel; At least one vacuum pump, each of the vacuum pumps is connected to one of the circulation pipes.

2. The powder mixing device for preparing diclofenac sodium enteric-coated tablets according to claim 1, characterized in that: The inner cylinder comprises a premixing device, which is communicated with the feed hopper of the outer cylinder and is used for preliminarily mixing the powder.

3. The powder mixing device for the preparation process of Diclofenac Sodium Enteric-coated Tablets according to claim 2, characterized in that: The premixing device is an upwardly convex arc-shaped structure, and the concave end of the premixing device is fixed on the top end of the rotating shaft.

4. The powder mixing device for the preparation process of diclofenac sodium enteric-coated tablets according to claim 3, characterized in that: A heating wire is arranged at the bottom of the premixing device.

5. The powder mixing device for the preparation process of diclofenac sodium enteric-coated tablets according to claim 3, characterized in that: The upper part of the inner cylinder is open, and the top end of the rotating shaft is located outside the inner cylinder.

6. The powder mixing device for the preparation process of diclofenac sodium enteric-coated tablets according to claim 5, characterized in that: The outer cylinder includes a flow guide device, which is a truncated cone structure with upper and lower openings. The top radius of the flow guide device is greater than the bottom radius. The side wall of the flow guide device extends downward from the inner wall of the outer cylinder and passes through the gap between the premixing device and the top of the inner cylinder.

7. The powder mixing device for preparing diclofenac sodium enteric-coated tablets according to any one of claims 1 to 6, characterized in that: A plurality of circumferentially distributed stirring blades are arranged on the upper part of the inner wall of the inner cylinder.

8. The powder mixing device for the preparation process of diclofenac sodium enteric-coated tablets according to any one of claims 1 to 6, characterized in that: A plurality of through holes are circumferentially arranged on the lower portion of the inner cylinder side wall.

9. The powder mixing device for preparing diclofenac sodium enteric-coated tablets according to any one of claims 1 to 6, characterized in that: The bottom of the outer cylinder is provided with a discharge port.

10. A powder mixing method for preparing diclofenac sodium enteric-coated tablets, characterized in that: The powder mixing device for preparing diclofenac sodium enteric-coated tablets according to any one of claims 1 to 9 comprises the following steps: (1) Powder is put into the inner cylinder for mixing; (2) The vacuum pump is started, and the circulation pipe returns the mixed powder to the inner cylinder for remixing.

11. The powder mixing method for preparing diclofenac sodium enteric-coated tablets according to claim 10, characterized in that: Step (1) comprises: the powder first falls onto the premixing device for preliminary mixing; while the powder moves from top to bottom in the inner cylinder, the stirring blades and the cylinder body of the inner cylinder stir and mix the powder; and under the action of centrifugal force, the mixed powder enters the cavity between the outer cylinder and the inner cylinder through the through hole.

12. The powder mixing method for preparing diclofenac sodium enteric-coated tablets according to claim 10 or 11, characterized in that: Step (1) comprises: the powder first falls onto the premixing device for heating and preliminary mixing.

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