A nicotine replacement compound, atomizing liquid composition and preparation method thereof, and electronic atomizing device

Abstract

The present invention discloses a nicotine replacement compound, an atomizing liquid composition and a preparation method thereof, and an electronic atomizing device. The nicotine replacement compound comprises 5-ethynyl nicotine, cis-1-methyl-1,2,3a,4,8b-hexahydropyrrole [3,2f] indolizine, GTS-21, PNU-282987, SEN12333, ABT-107, ABT-594, TC-1698 and ABT-089. When the nicotine replacement compound of the present invention is used for atomization, the atomizing liquid is atomized by an aerosol atomization system to obtain a better sensory experience; the throat hit experience of nicotine inhalation by an electronic cigarette is achieved, and the dependence on nicotine can be reduced.

Description

Technical Field

[0001] The present invention relates to electronic cigarette technology, and in particular to a nicotine replacement compound, an atomizing liquid composition and a preparation method thereof, and an electronic atomizing device. Background Art

[0002] Nicotine, as a representative of nicotine receptor agonists, is widely used in tobacco products. At present, nicotine products mainly include cigarettes, electronic cigarettes, heat-not-burn, and snus. Cigarettes are the most common tobacco products, usually made of finely shredded tobacco leaves and packaged in paper rolls. Electronic cigarettes are a tobacco substitute that does not require combustion. They produce aerosols for inhalation by heating tobacco oil or nicotine solution. Electronic cigarettes are considered to be an alternative to reducing the harm of traditional smoking. Heat-not-burn products reduce the release of harmful substances by heating tobacco instead of burning it. This type of product is between traditional tobacco and electronic cigarettes, retaining some of the tobacco experience while reducing the inhalation of harmful substances. Snus is a nicotine delivery system that has become popular in recent years. It allows nicotine to be absorbed through the oral mucosa, which can quickly relieve smoking addiction.

[0003] However, there is no ideal nicotine substitute to replace nicotine use. In the market areas with low nicotine content restrictions, the satisfaction and throat hit of nicotine cannot meet the needs of consumers. Summary of the invention

[0004] The present invention aims to solve at least one of the technical problems existing in the prior art. To this end, the present invention provides a nicotine replacement compound, which does not contain nicotine, while obtaining a similar puffing experience of a nicotine aerosol product, with a higher satisfaction and throat hit experience.

[0005] The present invention also provides an atomized liquid composition having the nicotine replacement compound.

[0006] The present invention also provides a method for preparing the atomized liquid composition.

[0007] The present invention also provides an electronic atomization device having the atomization liquid composition.

[0008] According to the first aspect of the present invention, an embodiment provides a nicotine replacement compound, including 5-ethynyl nicotine (CAS No.: 179120-92-4), cis-1-methyl-1,2,3a,4,8b-hexahydropyrrolo[3,2f]indolizine, GTS-21 (CAS No.: 148372-04-7), PNU-282987 (CAS No.: 123464-89-1), SEN12333 (CAS No.: 874450-44-9), ABT-107 (CAS No.: 855291-54-2), ABT-594 (CAS No.: 198283-73-7), TC-1698 (CAS No.: 700834-58-8), and ABT-089 (CAS No.: 161417-03-4).

[0009] The nicotine replacement compound according to the embodiment of the present invention has at least the following beneficial effects:

[0010] Provides a nicotine-like sensory experience. Nicotine, as one of the key ingredients in traditional tobacco products, can produce a "throat hit" and "pleasure" through its unique stimulating effect. These sensory experiences are usually one of the reasons why smokers continue to smoke. However, nicotine itself is highly addictive and has potential health hazards, especially negative effects on the cardiovascular, nervous system and lungs.

[0011] The nicotine replacement compound of the present invention is a combination of 5-ethynyl nicotine, cis-1-methyl-1,2,3a,4,8b-hexahydropyrrole [3,2f] indolizine, GTS-21, PNU-282987, SEN12333, ABT-107, ABT-594, TC-1698 and ABT-089, which are used in atomized liquid. Under the condition of not containing nicotine, after being atomized by an aerosol atomization system, a better sensory experience is obtained; the throat hit experience of nicotine inhalation in an electronic cigarette is achieved.

[0012] Furthermore, the nicotine replacement compound of the present invention can avoid the negative effects of nicotine itself, and the ingredients in the compound of the present invention (such as 5-ethynyl nicotine, cis-1-methyl-1,2,3a,4,8b-hexahydropyrrole [3,2f] indolizine, GTS-21, PNU-282987, SEN12333 and ABT-418) do not have the toxicity and addictiveness of nicotine, and therefore will not cause nicotine dependence on the user. These ingredients can effectively avoid the cardiovascular stress, addictive reactions and over-activation of the nervous system caused by nicotine, and do not involve the harmful smoke and chemicals produced during traditional smoking. This means that users can enjoy a nicotine-like experience without having to worry about the health risks caused by long-term use, especially the negative effects on cardiovascular health and the respiratory system.

[0013] According to some embodiments of the present invention, the mass ratio of 5-ethynyl nicotine, cis-1-methyl-1,2,3a,4,8b-piperazine[3,2f]indolizine, GTS-21, PNU-282987, SEN12333, ABT-107, ABT-594, TC-1698 and ABT-089 is 1:0.1-2:0.1-2:0.1-2:0.1-2:0.1-2:0.1-2:0.1-2:0.1-2:0.1-2.

[0014] The second embodiment of the present invention provides an atomized liquid composition, comprising the nicotine replacement compound according to the first aspect of the present invention, a sweetener, a cooling agent, an acidulant, a flavor and an alcohol solvent.

[0015] Therefore, the nicotine replacement compound of the present invention is combined with sweeteners, cooling agents, sour agents, and flavors to enable the atomized liquid of the present invention to obtain a better sensory experience after being atomized by the aerosol atomization system, thereby achieving the throat hit experience of inhaling nicotine in an electronic cigarette.

[0016] Furthermore, the addition of sweeteners, sour agents and cooling agents can enhance the taste and flavor of the product and improve the user experience.

[0017] According to some embodiments of the present invention, the atomized liquid composition comprises the following components by mass percentage:

[0018] Nicotine replacement compound 0.01wt.%~2.0wt.%;

[0019] Sweetener 0.2wt.%~5wt.%;

[0020] Cooling agent 0.1wt.%~20wt.%;

[0021] Acidulant 0.5wt.%~5wt.%;

[0022] Fragrance 1wt.%~60wt.%;

[0023] The balance is alcohol solvent.

[0024] According to some embodiments of the present invention, calculated based on 100 parts, the sweetener includes 8-12 parts of erythritol, 8-12 parts of sorbitol, 8-12 parts of mannitol, 3-7 parts of sucralose, 8-12 parts of cyclamate, 8-12 parts of acesulfame potassium, 8-12 parts of steviol glycosides, 0.5-2 parts of neotame, 0.1-1 parts of advantame, 0.5-2 parts of glycine, 0.5-2 parts of citric acid, and the balance is propylene glycol.

[0025] According to some embodiments of the present invention, based on 100 parts, the sweetener includes 10 parts of erythritol, 10 parts of sorbitol, 10 parts of mannitol, 5 parts of sucralose, 10 parts of cyclamate, 10 parts of acesulfame potassium, 10 parts of steviol glycosides, 1 part of neotame, 0.5 parts of adventitone, 1 part of glycine, 1 part of citric acid, and 46.5 parts of propylene glycol. Thus, the mixed formula of sweeteners can simulate the sweetness of sugar while avoiding the unpleasant taste that may be caused by a single sweetener. By combining different sweeteners, a more natural and balanced sweetness experience can be obtained; on the other hand, different sweeteners may interact with each other to provide a more stable and lasting sweetness.

[0026] According to some embodiments of the present invention, based on 100 parts, the cooling agent includes 30-50 parts of WS-23, 2-8 parts of WS-3, 2-8 parts of menthyl lactate, and the balance is propylene glycol.

[0027] According to some embodiments of the present invention, the cooling agent includes 45 parts of WS-23, 5 parts of WS-3, 5 parts of menthyl lactate, and 45 parts of propylene glycol, calculated as 100 parts. Thus, a refreshing feeling can be produced in the mouth, throat or skin. They simulate the cool feeling by combining with the cold receptors of the human body, giving people a comfortable and refreshing experience. WS-23 is relatively mild and lasting in the intensity of the cool feeling, and is suitable for long-term use.

[0028] According to some embodiments of the present invention, calculated based on 100 parts, the acidulant includes 20-40 parts of benzoic acid, 6-12 parts of lactic acid, 2-8 parts of levulinic acid, 2-8 parts of acetic acid, 0.5-2 parts of butyric acid, 1-5 parts of 2-methylbutyric acid, 2-7 parts of citric acid, 1-5 parts of malic acid, 1-5 parts of tartaric acid, and the balance is propylene glycol.

[0029] According to some embodiments of the present invention, the acidulant includes 30 parts of benzoic acid, 10 parts of lactic acid, 5 parts of levulinic acid, 5 parts of acetic acid, 1 part of butyric acid, 2 parts of 2-methylbutyric acid, 5 parts of citric acid, 2 parts of malic acid, 2 parts of tartaric acid, and 38 parts of propylene glycol, calculated as 100 parts. Thus, the atomized mouthfeel can be adjusted and the irritation caused by the nicotine receptor agonist can be reduced. Thus, through the combination of these acidulants, the multi-layered and complex sense of sourness can be achieved without being monotonous, so that the product has a richer taste and meets the taste needs of different consumers.

[0030] According to some embodiments of the present invention, the flavor includes at least one of tobacco flavor, strawberry flavor, mango flavor, blueberry flavor, apple flavor, and mint flavor.

[0031] According to some embodiments of the present invention, the alcohol solvent includes propylene glycol and glycerol.

[0032] The method for preparing the atomized liquid composition according to the third aspect of the present invention comprises the following steps:

[0033] The nicotine replacement compound described in the first aspect of the present invention, a sweetener, a cooling agent, a sour agent, a flavor and an alcohol solvent are mixed to obtain the nicotine replacement compound.

[0034] According to a fourth aspect of the present invention, an electronic atomization device is provided, comprising the atomization liquid composition described in the first aspect of the present invention and an electronic atomizer.

[0035] Additional aspects and advantages of the present invention will be given in part in the following description and in part will be obvious from the following description, or will be learned through practice of the present invention. DETAILED DESCRIPTION

[0036] Embodiments of the present invention are described in detail below. The described embodiments are exemplary and are only used to explain the present invention, and should not be construed as limiting the present invention.

[0037] In the description of the present invention, unless otherwise clearly defined, terms such as setting, installing, connecting, etc. should be understood in a broad sense, and technicians in the relevant technical field can reasonably determine the specific meanings of the above terms in the present invention based on the specific content of the technical solution.

[0038] In the description of the present invention, the description with reference to the terms "one embodiment", "some embodiments", "illustrative embodiments", "examples", "specific examples", or "some examples" means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described may be combined in any one or more embodiments or examples in a suitable manner.

[0039] The raw materials used in the embodiments and comparative examples of the present invention are as follows:

[0040] Nicotine replacement compounds: 5-ethynyl nicotine, cis-1-methyl-1,2,3a,4,8b-hexahydropyrrolo[3,2f]indolizine, GTS-21, PNU-282987, SEN12333, ABT-107, ABT-594, TC-1698 and ABT-089 were purchased from Shanghai Aladdin Biochemical Technology Co., Ltd.

[0041] Sweeteners: erythritol, sorbitol, mannitol, sucralose, cyclamate, acesulfame potassium, steviol glycosides, neotame, advantame, glycine, and citric acid were purchased from Shanghai MacLean Biochemical Technology Co., Ltd.

[0042] Cooling agents: WS-23, WS-3, and menthyl lactate were purchased from AIPU Fragrance Group Co., Ltd.

[0043] Acidulants: benzoic acid, lactic acid, levulinic acid, acetic acid, butyric acid, 2-methylbutyric acid, citric acid, malic acid, and tartaric acid were purchased from Shanghai Aladdin Biochemical Technology Co., Ltd.

[0044] Flavor: mango flavor; purchased from Shenzhen Boton Flavor Co., Ltd.

[0045] Example 1

[0046] This example provides a nicotine replacement compound, the components of which include 5-ethynyl nicotine, cis-1-methyl-1,2,3a,4,8b-hexahydropyrrolo[3,2f]indolizine, GTS-21, PNU-282987, SEN12333, ABT-107, ABT-594, TC-1698 and ABT-089. The preparation method is: mix them in a mass ratio of 1:0.5:0.2:0.2:0.4:0.2:0.5:0.3:0.2.

[0047] This example further provides an atomized liquid composition, the preparation method of which is as follows, and the amount of each component is shown in Table 1.

[0048] The nicotine replacement compound, the sweetener, the cooling agent, the sour agent, the flavor and the alcohol solvent are mixed in sequence to obtain the product.

[0049] Embodiments 2 to 5

[0050] Examples 2 to 5 provide a series of atomized liquid compositions, the preparation methods of which are the same as those of Example 1, and the amounts of the various components used are shown in Table 1.

[0051] Table 1

[0052]

[0053] Among them, calculated based on 100 parts, the formula of sweeteners is 10 parts of erythritol, 10 parts of sorbitol, 10 parts of mannitol, 5 parts of sucralose, 10 parts of cyclamate, 10 parts of acesulfame potassium, 10 parts of steviol glycosides, 1 part of neotame, 0.5 parts of Advantame, 1 part of glycine, 1 part of citric acid, and 46.5 parts of propylene glycol.

[0054] Calculated based on 100 parts, the formula of the cooling agent is 45 parts of WS-23, 5 parts of WS-3, 5 parts of menthyl lactate, and 45 parts of propylene glycol.

[0055] Calculated based on 100 parts, the formula of the acidulant includes 30 parts of benzoic acid, 10 parts of lactic acid, 5 parts of levulinic acid, 5 parts of acetic acid, 1 part of butyric acid, 2 parts of 2-methylbutyric acid, 5 parts of citric acid, 2 parts of malic acid, 2 parts of tartaric acid, and 38 parts of propylene glycol.

[0056] Comparative Example 1

[0057] This example provides an aerosol liquid composition, the preparation method and dosage of which are the same as those of Example 1, except that nicotine is used to replace the nicotine receptor agonist.

[0058] Comparative Example 2

[0059] This example provides an atomized liquid composition, the preparation method and dosage of which are the same as those of Example 1, except that cis-1-methyl-1,2,3a,4,8b-hexahydropyrrole[3,2f]indolizine is missing.

[0060] Comparative Example 3

[0061] This example provides an aerosol liquid composition, the preparation method and dosage of which are the same as those of Example 1, except that 5-ethynyl nicotine is missing.

[0062] Performance Testing

[0063] The sensory quality of the atomized liquid prepared in Examples 1 to 5 of the present invention was evaluated. The evaluation was conducted from six aspects: aroma quality, aroma quantity, harmony, irritation, miscellaneous smell, and throat hit. The maximum scale of each evaluation item was 9 points, and each evaluation item was scored in 1 point. The specific evaluation criteria are shown in Table 2.

[0064] Table 2

[0065] Points Fragrance Aroma volume Harmony Irritant Miscellaneous gas Throat hit 9 very good adequate Very harmonious Very small Very light very good 8 good foot Harmony Small light good 7 better More adequate More harmonious Smaller Lighter better 6 Slightly better Slightly Harmony Slightly smaller Slightly lighter Slightly better 5 middle middle middle middle middle middle 4 Slightly worse Slightly Slightly inharmonious Slightly larger Slightly heavier Slightly worse 3 Poor Lighter Less harmonious Larger Heavy Poor 2 Difference light Disharmony big Heavy Difference 1 Very bad Very light Very discordant Very large Very heavy Very bad

[0066] Evaluation method: Provide samples and sensory quality evaluation standard forms to 15 professional e-cigarette evaluation technicians (e-cigarette flavorists), and evaluate various indicators according to the requirements of the form.

[0067] The evaluation results of all 15 inhalation evaluation technical experts are valid. The arithmetic mean of the individual inhalation evaluation results of each inhalation evaluation expert is calculated, and the result is retained to one decimal place. The arithmetic mean of each individual item is added up to obtain the total score. The results are shown in Table 3.

[0068] Table 3

[0069]

[0070]

[0071] From the experimental data in Table 3, it can be seen that the atomized liquids of Examples 1 to 5 of the present invention do not contain nicotine. The present invention achieves a throat hit similar to that of Comparative Example 1 through a reasonable combination of nicotine receptor agonists, indicating that the atomized liquid composition of the present invention achieves a higher sensory experience and throat hit, and can reduce people's dependence on nicotine.

[0072] Comparative Examples 2 and 3, lacking cis-1-methyl-1,2,3a,4,8b-hexahydropyrrolo[3,2f]indolizine and 5-ethynyl nicotine, obtained lower scores, indicating that these two ingredients are key ingredients in the nicotine replacement composition.

[0073] The embodiments of the present invention are described in detail, but the present invention is not limited to the above embodiments. Various changes can be made within the knowledge of ordinary technicians in the relevant technical field without departing from the purpose of the present invention. In addition, the embodiments of the present invention and the features in the embodiments can be combined with each other without conflict.

Claims

1. A nicotine replacement compound, characterized in that Including 5-ethynyl nicotine, cis-1-methyl-1,2,3a,4,8b-hexahydropyrrolo[3,2f]indolizine, GTS-21, PNU-282987, SEN12333, ABT-107, ABT-594, TC-1698 and ABT-089.

2. The nicotine replacement compound according to claim 1, characterized in that The mass ratio of the 5-ethynyl nicotine, cis-1-methyl-1,2,3a,4,8b-piperazine[3,2f]indolizine, GTS-21, PNU-282987, SEN12333, ABT-107, ABT-594, TC-1698 and ABT-089 is 1:0.1-2:0.1-2:0.1-2:0.1-2:0.1-2:0.1-2:0.1-2:0.1-2.

3. An atomized liquid composition, characterized in that: The invention comprises the nicotine replacement compound according to claim 1 or 2, a sweetener, a cooling agent, a sour agent, a flavor and an alcohol solvent.

4. The atomized liquid composition according to claim 3, characterized in that: Calculated by mass percentage, it includes the following components: Nicotine replacement compound 0.01wt.%~2.0wt.%; Sweetener 0.2wt.%~5wt.%; Cooling agent 0.1wt.%~20wt.%; Acidulant 0.5wt.%~5wt.%; Fragrance 1wt.%~60wt.%; The balance is alcohol solvent.

5. The atomized liquid composition according to claim 3, characterized in that: Calculated based on 100 parts, the sweetener includes 8-12 parts of erythritol, 8-12 parts of sorbitol, 8-12 parts of mannitol, 3-7 parts of sucralose, 8-12 parts of cyclamate, 8-12 parts of acesulfame potassium, 8-12 parts of steviol glycosides, 0.5-2 parts of neotame, 0.1-1 parts of advantame, 0.5-2 parts of glycine, 0.5-2 parts of citric acid, and the balance is propylene glycol.

6. The atomized liquid composition according to claim 3, characterized in that: Calculated based on 100 parts, the cooling agent includes 30-50 parts of WS-23, 2-8 parts of WS-3, 2-8 parts of menthyl lactate, and the balance is propylene glycol.

7. The atomized liquid composition according to claim 3, characterized in that: Calculated based on 100 parts, the acidulant includes 20-40 parts of benzoic acid, 6-12 parts of lactic acid, 2-8 parts of levulinic acid, 2-8 parts of acetic acid, 0.5-2 parts of butyric acid, 1-5 parts of 2-methylbutyric acid, 2-7 parts of citric acid, 1-5 parts of malic acid, 1-5 parts of tartaric acid, and the balance is propylene glycol.

8. The atomized liquid composition according to claim 3, characterized in that: The flavor includes at least one of tobacco flavor, strawberry flavor, mango flavor, blueberry flavor, apple flavor, and mint flavor.

9. The method for preparing the atomized liquid composition according to any one of claims 3 to 8, characterized in that: The steps include: The nicotine replacement compound according to claim 1 or 2, a sweetener, a cooling agent, a sour agent, a flavor and an alcohol solvent are mixed to obtain the product.

10. An electronic atomization device, characterized in that: It comprises the atomizing liquid composition according to any one of claims 3 to 8 and an electronic atomizer.

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