Full-view three-dimensional lipid optical imaging system and equipment

Abstract

The invention discloses a full-view three-dimensional lipid optical imaging system and equipment. The imaging system comprises a laser emitting unit, a one-to-N optical fiber bundle, an annular ultrasonic transducer, a control unit, a liquid container and a water level control unit, sound conducting liquid is contained in the liquid container; the control unit outputs water level control information, and the water level control unit controls the imaging surface of the annular ultrasonic transducer to be flush with the horizontal plane of the sound conducting liquid according to the water level control information; an annular light beam emitted by the laser emitting unit passes through a to-be-detected target to an imaging surface of the annular ultrasonic transducer and generates a plurality of photoacoustic signals, the annular ultrasonic transducer receives the photoacoustic signals and generates an electric signal, and the control unit receives the electric signal and performs signal processing and image reconstruction to form a three-dimensional lipid image of the to-be-detected target. The full-view imaging of the to-be-detected target is realized, the excitation efficiency of the photoacoustic signal is ensured, the absorption of the sound conducting liquid is reduced, and the imaging effect is ensured.

Description

Technical Field

[0001] The present invention relates to the technical field of photoacoustic imaging, and in particular to a full-view three-dimensional lipid optical imaging system and equipment. Background Art

[0002] Photoacoustic imaging is a non-invasive imaging technology that combines laser excitation and ultrasonic detection. It is widely used in medicine, biology, materials science and other fields. It has both the strong deep tissue imaging capability of ultrasound and the characteristics of optical high resolution and high contrast. It can also be combined with multi-wavelength scanning to perform photoacoustic spectral imaging and realize the ability to extract functional information.

[0003] At present, three-dimensional lipid scanning is of great significance in the diagnosis and treatment of clinical lipid-related diseases and health management. Lipid metabolism disorders are closely related to the occurrence and development of many diseases, such as cardiovascular disease, obesity, diabetes, etc. Although traditional fat detection methods such as body fat meters, CT and MRI can provide a certain degree of fat distribution information, they have disadvantages in terms of accuracy, safety, cost or operation complexity. Photoacoustic imaging technology has shown great application potential in lipid imaging with its unique advantages. However, the existing implementation method uses a linear array ultrasonic transducer and scans each cross section of the linear array ultrasonic transducer to achieve three-dimensional lipid photoacoustic imaging. The laser excitation acoustic signal efficiency is low and the imaging viewing angle is limited. Summary of the invention

[0004] The present invention provides a full-view three-dimensional lipid optical imaging system and equipment to improve the excitation efficiency of photoacoustic signals while ensuring the imaging viewing angle, thereby improving the three-dimensional lipid optical imaging effect.

[0005] According to one aspect of the present invention, there is provided a full-view three-dimensional lipid optical imaging system, comprising: a laser emission unit, a one-to-N optical fiber bundle, a ring-shaped ultrasonic transducer, a control unit, a liquid container and a water level control unit;

[0006] The output end of the laser output unit is connected to the input end of the one-branch N optical fiber bundle; the control unit is connected to the annular ultrasonic transducer and the water level control unit respectively; the water level control unit is connected to the annular ultrasonic transducer and the water level control unit respectively, and the liquid container contains the sound-conducting liquid;

[0007] The annular ultrasonic transducer comprises an annular portion and a central hollow portion, wherein the central hollow portion is used to place a target to be detected, and the N output ends of the one-to-N optical fiber bundle are evenly distributed on the annular portion and face the central hollow portion, and the laser beams emitted from the N output ends form an annular beam, wherein N≥3;

[0008] The annular ultrasonic transducer and at least a portion of the target to be detected are immersed in the sound-conducting liquid; the control unit outputs water level control information, and the water level control unit controls the imaging surface of the annular ultrasonic transducer to be flush with the horizontal surface of the sound-conducting liquid according to the water level control information;

[0009] The annular light beam passes through the target to be detected to the imaging surface of the annular ultrasonic transducer and generates a plurality of photoacoustic signals. The annular ultrasonic transducer receives the photoacoustic signals and generates electrical signals. The control unit receives the electrical signals and performs signal processing and image reconstruction to form a three-dimensional lipid image of the target to be detected.

[0010] Optionally, the water level control unit comprises at least a first motor, a second motor and a liquid level regulating water tank; the liquid level regulating water tank is at least partially immersed in the sound-conducting liquid;

[0011] The control unit is connected to the first motor and the second motor respectively, the first motor is connected to the annular ultrasonic transducer, and the first motor is used to control the lifting and lowering state of the annular transducer; the second motor is connected to the liquid level regulating water tank, and the second motor is used to control the lifting and lowering state of the liquid level regulating water tank; wherein the moving direction of the annular ultrasonic transducer is opposite to the moving direction of the liquid level regulating water tank.

[0012] Optionally, the first motor and the second motor are started synchronously.

[0013] Optionally, the cross-sectional area of ​​the liquid container along the first direction is S1, the operating speed of the first motor is V1, the cross-sectional area of ​​the liquid level regulating water tank along the first direction is S2, and the operating speed of the second motor is V2, wherein S1*V1=S2*V2;

[0014] Wherein, the first direction is a direction parallel to the horizontal plane where the sound-conducting liquid is located.

[0015] Optionally, the angle between the light emitting directions of the N output ends of the one-to-N optical fiber bundle and the plane where the sound-conducting liquid is located is θ, wherein 30°≤θ≤60°.

[0016] Optionally, the laser emitting unit includes a laser source, a half-wave plate, a Glan prism and a fiber coupler arranged in sequence along the optical path, the laser source emits a first laser beam, the first laser beam is energy-adjusted in sequence by the half-wave plate and the Glan prism to generate a second laser beam that is emitted to the fiber coupler, and the fiber coupler couples the second laser beam to the one-to-N fiber beam.

[0017] Optionally, the wavelength of the first laser beam is λ, where 1180≤λ≤2500nm.

[0018] Optionally, the laser source emits the first laser beam of the same wavelength within a preset time; or, the laser source cyclically emits the first laser beams of different wavelengths within a preset time.

[0019] Optionally, a plurality of ultrasonic transducer array elements are disposed on the annular portion, and the ultrasonic transducer array elements are arranged in a circular array.

[0020] According to another aspect of the present invention, a full-view three-dimensional lipid optical imaging device is provided, comprising the full-view three-dimensional lipid optical imaging system described in any one of the above aspects.

[0021] The technical solution of the embodiment of the present invention provides a full-view three-dimensional lipid optical imaging system including: a laser emitting unit, a one-part-N optical fiber bundle, a ring-shaped ultrasonic transducer, a control unit, a liquid container and a water level control unit; the emitting end of the laser emitting unit is connected to the input end of the one-part-N optical fiber bundle; the control unit is respectively connected to the ring-shaped ultrasonic transducer and the water level control unit; the water level control unit is respectively connected to the ultrasonic transducer and the water level control unit, and the liquid container contains a sound-conducting liquid; the ring-shaped ultrasonic transducer includes a ring-shaped portion and a central hollow portion, the central hollow portion is used to place a target to be detected, and the N output ends of the one-part-N optical fiber bundle are evenly distributed on the ring-shaped portion and face In the central hollow part, the laser beams emitted from N output ends form an annular beam, wherein N≥3; the annular ultrasonic transducer and at least part of the target to be detected are immersed in the sound-conducting liquid; the control unit outputs water level control information, and the water level control unit controls the imaging surface of the annular ultrasonic transducer to be flush with the horizontal plane of the sound-conducting liquid according to the water level control information; the annular beam passes through the target to be detected to the imaging surface of the annular ultrasonic transducer, and generates multiple photoacoustic signals, the annular ultrasonic transducer receives the photoacoustic signal and generates an electrical signal, the control unit receives the electrical signal and performs signal processing and image reconstruction to form a three-dimensional lipid image of the target to be detected, and realizes full-view imaging of the target to be detected. At the same time, the excitation efficiency of the photoacoustic signal is guaranteed, the absorption of the sound-conducting liquid is reduced, and the imaging effect is guaranteed.

[0022] It should be understood that the contents described in this section are not intended to identify the key or important features of the embodiments of the present invention, nor are they intended to limit the scope of the present invention. Other features of the present invention will become easily understood through the following description. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the accompanying drawings required for use in the description of the embodiments will be briefly introduced below. Obviously, the accompanying drawings in the following description are only some embodiments of the present invention. For ordinary technicians in this field, other accompanying drawings can be obtained based on these accompanying drawings without paying creative work.

[0024] Figure 1 A schematic diagram of the structure of a full-view three-dimensional lipid optical imaging system provided by an embodiment of the present invention;

[0025] Figure 2 A full-view three-dimensional lipid photoacoustic image of different cross sections when the target to be measured is a plastic tube phantom filled with peanut oil and the wavelength of the laser beam is 1210nm provided in an embodiment of the present invention;

[0026] Figure 3 A full-view three-dimensional lipid photoacoustic image of different cross sections when the target to be measured is a mouse and the wavelength of the laser beam is 1210nm provided in an embodiment of the present invention;

[0027] Figure 4 An embodiment of the present invention provides a full-view three-dimensional lipid photoacoustic image of different cross sections when the target to be measured is a mouse and the wavelength of the laser beam is multi-wavelength. DETAILED DESCRIPTION

[0028] In order to enable those skilled in the art to better understand the scheme of the present invention, the technical scheme in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work should fall within the scope of protection of the present invention.

[0029] It should be noted that the terms "first", "second", etc. in the specification and claims of the present invention and the above-mentioned drawings are used to distinguish similar objects, and are not necessarily used to describe a specific order or sequence. It should be understood that the data used in this way can be interchanged where appropriate, so that the embodiments of the present invention described herein can be implemented in an order other than those illustrated or described herein. In addition, the terms "including" and "having" and any variations thereof are intended to cover non-exclusive inclusions, for example, a process, method, system, product or device that includes a series of steps or units is not necessarily limited to those steps or units that are clearly listed, but may include other steps or units that are not clearly listed or inherent to these processes, methods, products or devices.

[0030] Figure 1 Schematic diagram of the structure of a full-view three-dimensional lipid optical imaging system provided by an embodiment of the present invention. This embodiment can be applied to full-view three-dimensional lipid photoacoustic imaging. The full-view three-dimensional lipid optical imaging system 100 can be implemented in the form of hardware and / or software, such as Figure 1As shown, the full-view three-dimensional lipid optical imaging system 100 includes: a laser emitting unit 101, a one-part N optical fiber bundle 102, a ring-shaped ultrasonic transducer 103, a control unit 104, a liquid container 105 and a water level control unit 106; the emitting end of the laser emitting unit 101 is connected to the input end of the one-part N optical fiber bundle 102; the control unit 104 is respectively connected to the ring-shaped ultrasonic transducer 103 and the water level control unit 106; the water level control unit 106 is respectively connected to the ring-shaped ultrasonic transducer 103 and the water level control unit 106, and the liquid container 105 contains a sound-conducting liquid 107; the ring-shaped ultrasonic transducer 103 includes a ring-shaped portion 1031 and a central hollow portion 1032, the central hollow portion 1032 is used to place the target 10 to be detected, the N of the one-part N optical fiber bundle 102 The output ends are evenly distributed on the annular portion 1031 and face the central hollow portion 1032, and the laser light beams emitted from the N output ends form an annular light beam, wherein N≥3; the annular ultrasonic transducer 103 and at least part of the target 10 to be detected are immersed in the sound-conducting liquid 107; the control unit 104 outputs water level control information, and the water level control unit 106 controls the imaging surface of the annular ultrasonic transducer 103 to be flush with the horizontal plane of the sound-conducting liquid 107 according to the water level control information; the annular light beam passes through the target 10 to be detected to the imaging surface of the annular ultrasonic transducer 103, and generates multiple photoacoustic signals, the annular ultrasonic transducer 103 receives the photoacoustic signal and generates an electrical signal, the control unit 104 receives the electrical signal and performs signal processing and image reconstruction to form a three-dimensional lipid image of the target 10 to be detected.

[0031] Among them, the full-view three-dimensional lipid optical imaging system 100 includes a laser output unit 101, a one-part-N optical fiber bundle 102, a ring ultrasonic transducer 103, a control unit 104, a liquid container 105, and a water level control unit 106; the liquid container 105 contains an acoustic liquid 107, and the acoustic liquid 107 can be water or an ultrasonic coupling agent. The material selection of the specific acoustic liquid 107 can be selected according to actual design requirements, and the embodiment of the present invention does not make specific restrictions. The ring ultrasonic transducer 103 includes an annular portion 1031 and a central hollow portion 1032. The inner and outer peripheries of the exemplary annular portion 1031 are both circular, or the inner periphery of the annular portion 1031 is circular and the outer periphery is rectangular. Through the setting of the annular portion 1031, the output end of the one-part-N optical fiber bundle 102 can be evenly distributed on the annular portion 1031. The exemplary N is equal to 10, and the one-part-N optical fiber bundle 1021 is a one-part optical fiber bundle, thereby realizing the formation of an annular beam to ensure full-view three-dimensional lipid imaging of the target 10 to be detected. The central hollow portion 1032 of the annular ultrasonic transducer 103 is used to place the target 10 to be detected. The target 10 to be detected is partially immersed in the sound-conducting liquid 107 and partially exposed to the air, thereby ensuring the subsequent scanning and imaging of the target 10 to be detected. The output end of the laser output unit 101 is connected to the input end of the one-split N optical fiber bundle 102. The laser output unit 101 emits a laser beam, and the one-split N optical fiber bundle 102 receives the laser beam and splits it so that it is output along different output ends. Since the output ends of the one-split N optical fiber bundle 102 are evenly distributed along the annular portion of the annular ultrasonic transducer 103, the laser beams output from the N output ends form an annular beam. The control unit 104 is connected to the water level control unit 106. Part of the annular ultrasonic transducer 103 is immersed in the sound-conducting liquid 107 and part of it is exposed to the air. The control unit 104 outputs water level control information, and the water level control unit 106 controls the imaging surface of the annular ultrasonic transducer 103 to be flush with the horizontal plane of the sound-conducting liquid 107 according to the water level control information, so that when scanning and imaging the target 10 to be detected, the liquid level of the sound-conducting liquid 107 in the liquid container 105 is stably maintained on the imaging surface of the annular ultrasonic transducer 103, reducing the absorption of the annular light beam by the sound-conducting liquid 107 and ensuring the excitation effect of the acoustic and optical signals. At the same time, the control unit 104 is connected to the water level control unit 106. The control unit 104 receives the electrical signal fed back by the annular ultrasonic transducer 103, and performs signal processing and image reconstruction algorithm to generate lipid photoacoustic images of the target 10 to be detected under multiple excitations of different wavelengths. By performing spectral unmixing on the multiple photoacoustic images, the lipid photoacoustic images of the target 10 to be detected in different sections are solved, and finally a full-view three-dimensional lipid photoacoustic image of the target 10 to be detected is obtained. For example, Figure 2 The present invention provides a full-view three-dimensional lipid photoacoustic image of different cross sections when the target to be measured is a plastic tube phantom filled with peanut oil and the wavelength of the laser beam is 1210nm, such as Figure 2 As shown, it can be clearly seen that the central white area in the figure is the lipid distribution area, that is, the setting position of peanut oil; Figure 3 The present invention provides a full-view three-dimensional lipid photoacoustic image of different cross sections when the target to be measured is a mouse and the laser beam wavelength is 1210nm, such as Figure 3 As shown, the scanning range is from the mouse chest to the tail, from Figure 3 It can be clearly seen that the white area is the lipid distribution area.

[0032] The embodiment of the present invention arranges a laser emission unit, a one-to-N optical fiber bundle, an annular ultrasonic transducer, a control unit, a liquid container and a water level control unit in a full-view three-dimensional lipid optical imaging system, and reasonably controls the distribution state of the output end of the one-to-N optical fiber bundle in the annular portion of the annular ultrasonic transducer, so that the emitted laser beam is an annular beam, and irradiates the target to be detected located in the central hollow portion of the annular ultrasonic transducer, and generates multiple photoacoustic signals on the imaging surface of the annular ultrasonic transducer, the annular ultrasonic transducer receives the photoacoustic signal and generates an electrical signal, the control unit receives the electrical signal and performs signal processing and image reconstruction to form a three-dimensional lipid image of the target to be detected, and the full-view imaging of the target to be detected is realized. At the same time, the excitation efficiency of the photoacoustic signal is guaranteed, the absorption of the sound-conducting liquid is reduced, and the imaging effect is guaranteed.

[0033] Optionally, the water level control unit 106 includes at least a first motor 1061, a second motor 1062 and a liquid level regulating water tank 1063; the liquid level regulating water tank 1063 is at least partially immersed in the sound-conducting liquid 107; the control unit 104 is respectively connected to the first motor 1061 and the second motor 1062, the first motor 1061 is connected to the annular ultrasonic transducer 103, and the first motor 1061 is used to control the lifting and lowering state of the annular transducer; the second motor 1062 is connected to the liquid level regulating water tank 1063, and the second motor 1062 is used to control the lifting and lowering state of the liquid level regulating water tank 1063; wherein, the moving direction of the annular ultrasonic transducer 103 is opposite to the moving direction of the liquid level regulating water tank 1063.

[0034] The water level control unit 106 is specifically provided with a first motor 1061, a second motor 1062 and a liquid level regulating water tank 1063. For example, the liquid level regulating water tank 1063 may be in the shape of a rectangular parallelepiped. The specific shape may be selected according to actual design requirements, and the embodiment of the present invention does not specifically limit it. The first motor 1061 is connected to the annular ultrasonic transducer 103, and the depth of the annular ultrasonic transducer 103 immersed in the sound-conducting liquid 107 is adjusted by controlling the operating state of the first motor 1061, and the second motor 1062 is connected to the liquid level regulating water tank 1063, and the depth of the liquid level regulating water tank 1063 immersed in the sound-conducting liquid 107 is adjusted by controlling the operating state of the second motor 1062. The first motor 1061 and the second motor 1062 move in opposite directions, so that the movement of the annular ultrasonic transducer 103 The direction is opposite to the moving direction of the liquid level regulating water tank 1063. When the annular ultrasonic transducer 103 is in an ascending state, the liquid level regulating water tank 1063 is in a descending state; when the annular ultrasonic transducer 103 is in a descending state, the liquid level regulating water tank 1063 is in an ascending state, thereby ensuring that the horizontal plane of the sound-conducting liquid 107 in the liquid container 105 is always maintained on the imaging plane of the ultrasonic transducer, thereby ensuring the collection effect of the photoacoustic signal by the annular ultrasonic transducer 103, so as to achieve a full-view three-dimensional lipid photoacoustic imaging effect.

[0035] Optionally, the first motor 1061 and the second motor 1062 are started synchronously.

[0036] Among them, by presetting the operating parameters of the first motor 1061 and the second motor 1062 in the control unit 104, the operating parameters may include operating acceleration, speed, initial speed, speed unit, and at the same time ensure that the first motor 1061 and the second motor 1062 start at the same time, thereby ensuring that the first motor 1061 and the second motor 1062 start synchronously, thereby ensuring the control effect of the liquid level of the sound-conducting liquid, thereby making the liquid level always maintain on the imaging surface of the annular ultrasonic transducer 103, reducing the absorption of the laser beam by the sound-conducting liquid 107, ensuring the laser efficiency of the photoacoustic signal, so as to ensure the subsequent three-dimensional lipid photoacoustic imaging effect of the target 10 to be detected.

[0037] Optionally, the cross-sectional area of ​​the liquid container 105 along the first direction X is S1, the operating speed of the first motor 1061 is V1, the cross-sectional area of ​​the liquid level regulating water tank 1063 along the first direction X is S2, and the operating speed of the second motor 1062 is V2, wherein S1*V1=S2*V2; wherein the first direction X is a direction parallel to the horizontal plane direction along which the sound-conducting liquid 107 is located.

[0038] In which, during the synchronous movement of the first motor 1061 and the second motor 1062, the annular ultrasonic transducer 103 is driven by the first motor 1061 to scan up and down to obtain the photoacoustic data of the target 10 to be detected at different depth sections, and the liquid level regulating water tank 1063 is driven by the second motor 1062 to move up and down, and the liquid level of the sound-conducting liquid 107 is controlled by immersing the liquid level regulating water tank 1063 in the sound-conducting liquid 107 and floating out of the sound-conducting liquid. During the movement of the first motor 1061 and the second motor 1062, the two run in opposite directions to always keep the liquid volume The cross-sectional area of ​​the device 105 along the first direction X multiplied by the running speed of the first motor 1061 is equal to the cross-sectional area of ​​the liquid level regulating water tank 1063 along the first direction X multiplied by the running speed of the second motor 1062. The first direction X can be understood as the horizontal plane direction where the sound-conducting liquid 107 is always parallel to the placement plane of the liquid container 105, so that the liquid level of the sound-conducting liquid 107 in the liquid container 105 is always guaranteed to be at the imaging plane of the annular ultrasonic transducer 103, thereby ensuring the accuracy of the annular ultrasonic transducer 103 in acquiring the sound and light signals, and thus ensuring the subsequent three-dimensional imaging effect.

[0039] Optionally, the angle between the light emitting directions of the N output ends of the N-fiber bundle 102 and the plane where the sound-conducting liquid 107 is located is θ, wherein 30°≤θ≤60°.

[0040] Among them, the N output ends of the one-part-N optical fiber are evenly distributed in a ring shape along the annular portion 1031. For example, N is equal to 10 to form 10 output ends. The angle θ between the light emitting direction of each output end and the plane where the sound-conducting liquid 107 is located is reasonably set. The preferred angle θ is 45°, so that the light emitting direction of the N output ends of the one-part-N optical fiber bundle 102 is inclined downward at 45° to perform annular excitation on the target 10 to be detected placed in the annular portion 1031, so that the laser light beam reaches the target 10 to be detected without passing through the sound-conducting liquid 107 to avoid photoacoustic signal excitation, thereby ensuring the maximum acoustic signal laser efficiency, ensuring the reception of the acoustic signal by the annular ultrasonic transducer 103, and then ensuring the three-dimensional lipid scanning imaging effect.

[0041] Optionally, the laser emitting unit 101 includes a laser source, a half-wave plate, a Glan prism and a fiber coupler (not shown in the figure) arranged in sequence along the optical path. The laser source emits a first laser beam, and the first laser beam is energy-adjusted in sequence by the half-wave plate and the Glan prism to generate a second laser beam that is emitted to the fiber coupler. The fiber coupler couples the second laser beam to an N-fiber bundle 102.

[0042] Among them, the laser source can be an OPO pulse laser, the laser element outputs a first laser beam at a repetition frequency of 20HZ, and then uses a half-wave plate and a Glan prism combination to adjust the laser energy of the first laser beam to form a second laser beam, and the second laser beam is coupled into the one-N optical fiber bundle 102 through a fiber coupler, and arranged according to the output ends of the one-N optical fiber bundle 102, so as to ensure that the laser beam emitted by the laser source can be emitted to the target 10 to be detected in a ring-shaped beam, so as to ensure the ring-shaped excitation of the target 10 to be detected, and then realize the three-dimensional lipid photoacoustic imaging of the target 10 to be detected in full viewing angle, so as to intuitively view the lipid distribution information of the target to be detected.

[0043] Optionally, the wavelength of the first laser beam is λ, where 1180≤λ≤2500nm.

[0044] Among them, the laser output unit 101 needs to emit a first laser light beam of near-infrared wavelength to the target 10 to be detected, which can convert light energy into heat energy, causing instantaneous expansion of the tissue around the target 10 to be detected and the generation of photoacoustic signals, thereby facilitating the ultrasonic transducer to receive the photoacoustic signals. Therefore, the wavelength of the first laser beam is reasonably controlled within the range of 1180-2500nm to meet the needs of three-dimensional lipid photoacoustic imaging.

[0045] Optionally, the laser source emits a first laser beam with the same wavelength within a preset time; or, the laser source cyclically emits first laser beams with different wavelengths within a preset time.

[0046] In the process of scanning and imaging the target 10 to be detected, the preset time can be set according to the actual use time of the full-view three-dimensional lipid optical imaging system 100, such as Figure 2 and Figure 3 As shown, the laser source can continuously output a first laser beam of the same wavelength within a preset time to illuminate the target 10 to be detected, and then perform scanning imaging to obtain real-time three-dimensional lipid photoacoustic imaging images of different cross sections of the target 10 to be detected at the same wavelength; or Figure 4 The present invention provides a full-view three-dimensional lipid photoacoustic image of different cross sections when the target to be measured is a mouse and the wavelength of the laser beam is multi-wavelength, such as Figure 4 As shown, the laser source can cyclically emit first laser beams of different wavelengths within a preset time to illuminate the target 10 to be detected, and then perform scanning imaging to obtain real-time three-dimensional lipid photoacoustic imaging images of different cross sections of the target 10 to be detected at multiple wavelengths, such as Figure 4 As shown, it can be clearly seen that the white area is the lipid distribution area of ​​the mouse. The wavelength of the first laser beam emitted by the laser source can be set according to actual design requirements to ensure the acquisition of three-dimensional lipid photoacoustic imaging, and then obtain three-dimensional lipid distribution information to improve the accuracy of disease diagnosis, personalized treatment and health management.

[0047] Optionally, a plurality of ultrasonic transducer array elements are disposed on the annular portion 1031 , and the ultrasonic transducer array elements are arranged in a circular array.

[0048] Among them, a plurality of ultrasonic transducer array elements are arranged on the side of the annular portion 1031 of the ultrasonic transducer toward the central hollow portion 1032, and the ultrasonic transducer array elements are arranged in a uniform circular array according to the distribution of the annular portion 1031, which is conducive to the reception of all-round photoacoustic signals, thereby ensuring the subsequent three-dimensional imaging effect.

[0049] An embodiment of the present invention further provides a full-view three-dimensional lipid optical imaging device, comprising the full-view three-dimensional lipid optical imaging system described in any one of the above embodiments.

[0050] It should be noted that since the full-view three-dimensional lipid optical imaging device provided in this embodiment includes any of the full-view three-dimensional lipid optical imaging systems provided in the embodiments of the present invention, it has the same or corresponding beneficial effects as the full-view three-dimensional lipid optical imaging system, which will not be elaborated here.

[0051] The above specific implementations do not constitute a limitation on the protection scope of the present invention. It should be understood by those skilled in the art that various modifications, combinations, sub-combinations and substitutions can be made according to design requirements and other factors. Any modification, equivalent substitution and improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A full-view three-dimensional lipid optical imaging system, characterized in that: include: Laser emission unit, one-to-N optical fiber bundle, annular ultrasonic transducer, control unit, liquid container and water level control unit; The output end of the laser output unit is connected to the input end of the one-branch N optical fiber bundle; the control unit is connected to the annular ultrasonic transducer and the water level control unit respectively; the water level control unit is connected to the annular ultrasonic transducer and the water level control unit respectively, and the liquid container contains the sound-conducting liquid; The annular ultrasonic transducer comprises an annular portion and a central hollow portion, wherein the central hollow portion is used to place a target to be detected, and the N output ends of the one-to-N optical fiber bundle are evenly distributed on the annular portion and face the central hollow portion, and the laser beams emitted from the N output ends form an annular beam, wherein N≥3; The annular ultrasonic transducer and at least a portion of the target to be detected are immersed in the sound-conducting liquid; the control unit outputs water level control information, and the water level control unit controls the imaging surface of the annular ultrasonic transducer to be flush with the horizontal surface of the sound-conducting liquid according to the water level control information; The annular light beam passes through the target to be detected to the imaging surface of the annular ultrasonic transducer and generates a plurality of photoacoustic signals. The annular ultrasonic transducer receives the photoacoustic signals and generates electrical signals. The control unit receives the electrical signals and performs signal processing and image reconstruction to form a three-dimensional lipid image of the target to be detected.

2. The full-view three-dimensional lipid optical imaging system according to claim 1, characterized in that: The water level control unit comprises at least a first motor, a second motor and a liquid level regulating water tank; the liquid level regulating water tank is at least partially immersed in the sound-conducting liquid; The control unit is connected to the first motor and the second motor respectively, the first motor is connected to the annular ultrasonic transducer, and the first motor is used to control the lifting and lowering state of the annular transducer; the second motor is connected to the liquid level regulating water tank, and the second motor is used to control the lifting and lowering state of the liquid level regulating water tank; wherein the moving direction of the annular ultrasonic transducer is opposite to the moving direction of the liquid level regulating water tank.

3. The full-view three-dimensional lipid optical imaging system according to claim 2, characterized in that: The first motor and the second motor are started synchronously.

4. The full-view three-dimensional lipid optical imaging system according to claim 2, characterized in that: The cross-sectional area of ​​the liquid container along the first direction is S1, the operating speed of the first motor is V1, the cross-sectional area of ​​the liquid level regulating water tank along the first direction is S2, and the operating speed of the second motor is V2, wherein S1*V1=S2*V2; Wherein, the first direction is a direction parallel to the horizontal plane where the sound-conducting liquid is located.

5. The full-view three-dimensional lipid optical imaging system according to claim 1, characterized in that: The angle between the light emitting directions of the N output ends of the one-to-N optical fiber bundle and the plane where the sound-conducting liquid is located is θ, wherein 30°≤θ≤60°.

6. The full-view three-dimensional lipid optical imaging system according to claim 1, characterized in that: The laser emitting unit comprises a laser source, a half-wave plate, a Glan prism and a fiber coupler which are sequentially arranged along the optical path. The laser source emits a first laser beam, which is sequentially energy-adjusted by the half-wave plate and the Glan prism to generate a second laser beam which is emitted to the fiber coupler. The fiber coupler couples the second laser beam to the one-to-N fiber bundle.

7. The full-view three-dimensional lipid optical imaging system according to claim 6, characterized in that: The wavelength of the first laser beam is λ, wherein 1180≤λ≤2500nm.

8. The full-view three-dimensional lipid optical imaging system according to claim 6, characterized in that: The laser source emits the first laser beam of the same wavelength within a preset time; or, the laser source cyclically emits the first laser beams of different wavelengths within a preset time.

9. The full-view three-dimensional lipid optical imaging system according to claim 1, characterized in that: A plurality of ultrasonic transducer array elements are arranged on the annular portion, and the ultrasonic transducer array elements are arranged in a circular array.

10. A full-view three-dimensional lipid optical imaging device, characterized in that: A full-view three-dimensional lipid optical imaging system comprising any one of claims 1-9.

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