A composite selenium disulfide composition and its preparation method and application

Abstract

The present invention provides a composite selenium disulfide composition and its preparation method and application. The composite selenium disulfide composition, according to weight parts, includes the following raw materials: 2-4 parts of selenium disulfide, 1-2 parts of polyvinyl alcohol, 1-3 parts of sodium alginate, 4-6 parts of polyols, and 0.5-0.7 parts of accelerators. The preparation method of the composite selenium disulfide composition includes: (1) adding polyvinyl alcohol and a surfactant to water, ultrasonic stirring, and obtaining a dispersion a; (2) adding selenium disulfide and an accelerator to dispersion a, stirring evenly, and obtaining dispersion b; (3) mixing sodium alginate and polyols to obtain treated sodium alginate; (4) mixing the treated sodium alginate and dispersion b evenly, drying, and obtaining a composite selenium disulfide composition. The selenium disulfide of the present invention has good dispersibility, high stability, and low irritation. The prepared lotion can be used to treat dandruff, seborrheic dermatitis of the scalp and tinea versicolor caused by Malassezia, has good efficacy, and has good application prospects.

Description

Technical Field

[0001] The invention relates to the technical field of lotions, and in particular to a compound selenium disulfide composition and a preparation method and application thereof. Background Art

[0002] Dandruff is generally formed by the shedding of dead cells on the scalp. Under normal circumstances, dandruff is invisible to the naked eye, but when the scalp is affected by some internal and external factors, it will produce obvious visible dandruff. Dandruff is generally divided into physiological and pathological. Among them, pathological dandruff is caused by the infection of the scalp by bacteria, fungi and other colonies, and is specifically manifested as excessive dandruff, itchy scalp and other symptoms. For example, when the oil secretion on the scalp is excessive, Malassezia decomposes triglycerides in the oil to produce fatty acids, which stimulate the hair, making dandruff on the hair clearly visible and affecting people's lives.

[0003] Tinea versicolor refers to a skin disease caused by Malassezia fungus infection. It mainly occurs in hot summer and in young and middle-aged people, especially those who sweat easily. In clinical treatment, the main characteristics of the rash are the appearance of light brown patches, which are not protruding from the skin surface and have fine scales. There may also be pale white patches with unclear boundaries and fine scales, and there may be a certain itching sensation.

[0004] It can be seen that dandruff, seborrheic dermatitis and tinea versicolor caused by Malassezia trouble the lives of many people. Existing lotion products that inhibit the proliferation of Malassezia include zinc pyrithione (ZPT), piroctone olamine (OCT), selenium disulfide, etc.; but zinc pyrithione (ZPT) has been banned by the European Union due to its toxicity, and although piroctone olamine (OCT) is non-toxic and non-irritating, it is expensive and difficult to be widely used.

[0005] Selenium disulfide is cheap, but it is difficult to dissolve in water or disperse in the system, and has poor dispersibility. It is difficult to be used in lotion products. It manifests as stratification in the preparation and drug aggregation during topical medication, increasing the risk of toxic and side effects of selenium disulfide lotion on the skin. In addition, during actual use, when selenium disulfide lotion products are used to treat dandruff, seborrheic dermatitis of the scalp, and tinea versicolor, the selenium disulfide in the lotion is difficult to deposit on the skin surface during rinsing with running water, and selenium disulfide cannot play its due role. At the same time, selenium disulfide may be unstable in some cases and easily lose its activity due to the influence of external environments such as light and oxygen.

[0006] Therefore, it is necessary to solve the problems of dispersibility and stability of selenium disulfide, and maximize its efficacy in treating dandruff, seborrheic dermatitis and tinea versicolor caused by Malassezia under the premise of low irritation. Summary of the invention

[0007] In view of this, the present invention proposes a composite selenium disulfide composition and a preparation method and application thereof.

[0008] The technical solution of the present invention is achieved in this way:

[0009] A composite selenium disulfide composition comprises the following raw materials in parts by weight: 2-4 parts of selenium disulfide, 1-2 parts of polyvinyl alcohol, 1-3 parts of sodium alginate, 4-6 parts of polyol, and 0.5-0.7 parts of accelerator;

[0010] The accelerator is betaine and chlorogenic acid in a mass ratio of 2-4:1;

[0011] The polyols are propylene glycol, erythritol and sorbitol in a mass ratio of 3-5:1-3:1.

[0012] A method for preparing a composite selenium disulfide composition, the specific preparation steps comprising:

[0013] (1) adding polyvinyl alcohol and a surfactant into water and stirring with ultrasound to obtain a dispersion a;

[0014] (2) adding selenium disulfide and an accelerator to dispersion a and stirring uniformly to obtain dispersion b;

[0015] (3) mixing sodium alginate and polyol to obtain treated sodium alginate;

[0016] (4) The treated sodium alginate and dispersion b are mixed evenly, and dried to obtain a composite selenium disulfide composition.

[0017] Furthermore, in step (1), the surfactant is any one of sodium dodecyl sulfate, sodium lauryl polyoxyethylene ether sulfate or sodium stearate;

[0018] The mass ratio of the polyvinyl alcohol to the surfactant is 1:0.1-0.2; the solid-liquid ratio of the polyvinyl alcohol to water is 1:50-70 g / mL; and the ultrasonic stirring is performed at 20-30 KHz and 30-40° C. for 1-3 hours.

[0019] The invention discloses an application of a compound selenium disulfide composition in preparing a lotion product.

[0020] Furthermore, the lotion product comprises 5-10 wt% of the compounded selenium disulfide composition and 90-95 wt% of auxiliary materials.

[0021] Furthermore, the auxiliary materials include the following raw materials in parts by weight: 1.1-1.3 parts of suspending agent, 0.9-1 parts of sunscreen, 0.7-0.8 parts of pH regulator, 1.1-1.2 parts of emulsifier, 41-43 parts of foaming agent, 0.4-0.5 parts of flavor, and 1.5-1.6 parts of thickener.

[0022] Furthermore, the pH regulator is citric acid and sodium dihydrogen phosphate dihydrate in a mass ratio of 1-3:1; the foaming agent is lauryl sulfate monoethanolamine salt and dodecyl dimethyl betaine in a mass ratio of 35-40:1.

[0023] Furthermore, the preparation method of the lotion product comprises:

[0024] (1) adding a suspending agent, a sunscreen, a thickener and a pH adjuster into deionized water and performing ultrasonic treatment to obtain an aqueous phase I;

[0025] (2) adding a foaming agent into deionized water, ultrasonically treating the water, adding the composite selenium disulfide composition, and continuing to stir to obtain an aqueous phase II;

[0026] (3) heating and mixing the emulsifier and the flavor to obtain an oil phase;

[0027] (4) Adding water phase II to the oil phase and stirring, then adding water phase I and continuing to stir to form a mixture, homogenizing, and filling to obtain a lotion product.

[0028] Furthermore, in step (1), the solid-liquid ratio of the total mass of the suspending agent, the opacifying agent, the thickener and the pH regulator to the deionized water is 1:80-100 g / mL; the temperature of the ultrasonic treatment is 45-55°C, the time is 15-25 min, and the speed is 200-300 rpm;

[0029] In step (2), the solid-liquid ratio of the foaming agent to deionized water is 1:30-50 g / mL; the temperature of the ultrasonic treatment is 45-55° C., the time is 10-20 min, and the speed is 200-300 rpm; and the stirring time is 15-25 min.

[0030] Furthermore, in step (3), the heating, mixing and stirring is carried out at 45-55° C. for 8-12 min;

[0031] In step (4), the stirring time is 15-25 min; the continued stirring time is 10-20 min; the homogenization speed is 4500-5500 rpm, and the time is 10-20 min.

[0032] Compared with the prior art, the present invention has the following beneficial effects:

[0033] 1. The composite selenium disulfide composition of the present invention uses polyvinyl alcohol as a carrier of selenium disulfide, has good adhesion, can form a thin film on the skin surface, prolongs the time that selenium disulfide stays in contact with the skin, helps to improve the deposition effect of selenium disulfide, and better plays the role of treating dandruff, seborrheic dermatitis and tinea versicolor caused by Malassezia.

[0034] 2. The present invention mixes polyvinyl alcohol and a surfactant, and the surfactant reduces the surface tension between selenium disulfide particles, making it better dispersed in the solution, thereby improving the uniformity of selenium disulfide, preventing agglomeration, and reducing irritation.

[0035] 3. The polyol of the present invention is connected to the sodium alginate through hydrogen bonding to form a stable and uniform gel network structure, which reduces irritation and provides a good washing feeling. At the same time, the sodium alginate can form a stable ion interaction with the skin surface to form a stable adsorption layer, which reduces the loss of selenium disulfide, further improves the efficacy of dandruff, seborrheic dermatitis and tinea versicolor caused by Malassezia, and can also improve the stability of selenium disulfide.

[0036] 4. The accelerator of the present invention can promote the absorption of selenium disulfide by the skin. By controlling the composition and dosage of the accelerator, the binding ability of the skin and selenium disulfide can be increased without irritating the skin, thereby significantly improving the therapeutic effect of dandruff, seborrheic dermatitis and tinea versicolor caused by Malassezia. DETAILED DESCRIPTION

[0037] In order to better understand the technical content of the present invention, specific embodiments are provided below to further illustrate the present invention.

[0038] Unless otherwise specified, the experimental methods used in the embodiments of the present invention are all conventional methods.

[0039] Unless otherwise specified, the materials, reagents, etc. used in the embodiments of the present invention can be obtained from commercial sources.

[0040] The suspending agent of the invention is bentonite, the sunscreen is titanium dioxide, the emulsifier is ricin monooleate, and the thickener is sodium chloride.

[0041] The surfactant of the present invention is any one of sodium lauryl sulfate, sodium lauryl polyoxyethylene ether sulfate or sodium stearate.

[0042] The pH regulator of the present invention is citric acid and sodium dihydrogen phosphate dihydrate in a mass ratio of 1-3:1.

[0043] The foaming agent of the invention is lauryl sulfate monoethanolamine salt and dodecyl-tetradecyl dimethyl betaine in a mass ratio of 35-40:1.

[0044] Example 1

[0045] A composite selenium disulfide composition, comprising the following raw materials in parts by weight: 3 parts of selenium disulfide, 1.5 parts of polyvinyl alcohol, 2 parts of sodium alginate, 5 parts of polyol, and 0.6 parts of accelerator;

[0046] The promoters are betaine and chlorogenic acid in a mass ratio of 3:1; and the polyols are propylene glycol, erythritol and sorbitol in a mass ratio of 4:2:1.

[0047] The preparation method of the composite selenium disulfide composition comprises the following specific preparation steps:

[0048] (1) adding polyvinyl alcohol and a surfactant in a mass ratio of 1:0.15 to water, with a solid-liquid ratio of polyvinyl alcohol to water of 1:60 g / mL, and ultrasonically treating at 25 kHz and 35° C. for 2 h to obtain a dispersion a;

[0049] (2) adding selenium disulfide and an accelerator to dispersion a and stirring uniformly to obtain dispersion b;

[0050] (3) mixing sodium alginate and polyol to obtain treated sodium alginate;

[0051] (4) The treated sodium alginate and dispersion b are mixed evenly, and dried to obtain a composite selenium disulfide composition.

[0052] Example 2

[0053] A composite selenium disulfide composition, comprising the following raw materials in parts by weight: 2 parts of selenium disulfide, 1 part of polyvinyl alcohol, 1 part of sodium alginate, 4 parts of polyol, and 0.5 parts of accelerator;

[0054] The promoters are betaine and chlorogenic acid in a mass ratio of 2:1; and the polyols are propylene glycol, erythritol and sorbitol in a mass ratio of 3:1:1.

[0055] The preparation method of the composite selenium disulfide composition comprises the following specific preparation steps:

[0056] (1) adding polyvinyl alcohol and a surfactant in a mass ratio of 1:0.1 to water, wherein the solid-liquid ratio of polyvinyl alcohol to water is 1:50 g / mL, and ultrasonically treating the mixture at 20 kHz and 30° C. for 1 h to obtain a dispersion a;

[0057] (2) adding selenium disulfide and an accelerator to dispersion a and stirring uniformly to obtain dispersion b;

[0058] (3) mixing sodium alginate and polyol to obtain treated sodium alginate;

[0059] (4) The treated sodium alginate and dispersion b are mixed evenly, and dried to obtain a composite selenium disulfide composition.

[0060] Example 3

[0061] A composite selenium disulfide composition, comprising the following raw materials in parts by weight: 4 parts of selenium disulfide, 2 parts of polyvinyl alcohol, 3 parts of sodium alginate, 6 parts of polyol, and 0.7 parts of accelerator;

[0062] The promoters are betaine and chlorogenic acid in a mass ratio of 4:1; and the polyols are propylene glycol, erythritol and sorbitol in a mass ratio of 5:3:1.

[0063] The preparation method of the composite selenium disulfide composition comprises the following specific preparation steps:

[0064] (1) adding polyvinyl alcohol and a surfactant in a mass ratio of 1:0.2 to water, wherein the solid-liquid ratio of polyvinyl alcohol to water is 1:70 g / mL, and ultrasonically treating the mixture at 30 kHz and 40° C. for 3 h to obtain a dispersion a;

[0065] (2) adding selenium disulfide and an accelerator to dispersion a and stirring uniformly to obtain dispersion b;

[0066] (3) mixing sodium alginate and polyol to obtain treated sodium alginate;

[0067] (4) The treated sodium alginate and dispersion b are mixed evenly, and dried to obtain a composite selenium disulfide composition.

[0068] Comparative Example 1

[0069] The difference from Example 1 is that polyvinyl alcohol is missing; the rest is the same as Example 1.

[0070] Comparative Example 2

[0071] The difference from Example 1 is that sodium alginate and polyol are missing; the rest is the same as Example 1.

[0072] Comparative Example 3

[0073] The difference from Example 1 is that there is no accelerant; the rest is the same as Example 1.

[0074] A composite selenium disulfide composition, comprising the following raw materials in parts by weight: 3 parts of selenium disulfide, 1.5 parts of polyvinyl alcohol, 2 parts of sodium alginate, 5 parts of polyol, and 0.6 parts of accelerator;

[0075] Application Example 1

[0076] A selenium disulfide lotion product comprises 8 wt% of the compounded selenium disulfide composition of Example 1 and 92 wt% of auxiliary materials. The auxiliary materials include the following raw materials in parts by weight: 1.2 parts of suspending agent, 0.95 parts of sunscreen, 0.75 parts of pH regulator, 1.15 parts of emulsifier, 42 parts of foaming agent, 0.45 parts of flavor, and 1.55 parts of thickener.

[0077] The preparation method of the above lotion product comprises:

[0078] (1) adding a suspending agent, a sunscreen, a thickener and a pH regulator to deionized water, wherein the total mass of the suspending agent, the sunscreen, the thickener and the pH regulator and the solid-liquid ratio of the deionized water is 1:90 g / mL, and ultrasonically treating the mixture at 50° C. and 250 rpm for 20 min to obtain an aqueous phase I;

[0079] (2) adding a foaming agent to deionized water at a solid-liquid ratio of 1:40 g / mL, ultrasonically treating the mixture at 50° C. and 250 rpm for 15 min, adding the composite selenium disulfide composition, and continuing stirring for 20 min to obtain an aqueous phase II;

[0080] (3) heating the emulsifier and the flavor at 50° C. and mixing for 10 min to obtain an oil phase;

[0081] (4) Add water phase II to the oil phase and stir for 20 minutes, then add water phase I and continue stirring for 15 minutes to form a mixture, homogenize at 5000 rpm for 15 minutes, and fill to obtain a lotion product.

[0082] Application Example 2

[0083] A selenium disulfide lotion product comprises 5wt% of the compounded selenium disulfide composition of Example 2 and 95wt% of auxiliary materials. The auxiliary materials include the following raw materials in parts by weight: 1.1 parts of suspending agent, 0.9 parts of sunscreen, 0.7 parts of pH regulator, 1.1 parts of emulsifier, 41 parts of foaming agent, 0.4 parts of flavor, and 1.5 parts of thickener.

[0084] The preparation method of the above lotion product comprises:

[0085] (1) adding a suspending agent, a sunscreen, a thickener and a pH regulator to deionized water, wherein the total mass of the suspending agent, the sunscreen, the thickener and the pH regulator and the solid-liquid ratio of the deionized water is 1:80 g / mL, and ultrasonically treating the mixture at 45° C. and 200 rpm for 15 min to obtain an aqueous phase I;

[0086] (2) adding a foaming agent to deionized water at a solid-liquid ratio of 1:30 g / mL, ultrasonically treating the mixture at 45° C. and 200 rpm for 10 min, adding the composite selenium disulfide composition, and continuing stirring for 15 min to obtain an aqueous phase II;

[0087] (3) heating the emulsifier and the flavor at 45° C., mixing and stirring for 8 minutes to obtain an oil phase;

[0088] (4) Add water phase II to the oil phase and stir for 15 minutes, then add water phase I and continue stirring for 10 minutes to form a mixture, homogenize at 4500 rpm for 10 minutes, and fill to obtain a lotion product.

[0089] Application Example 3

[0090] A selenium disulfide lotion product comprises 10 wt% of the compounded selenium disulfide composition of Example 3 and 90 wt% of auxiliary materials. The auxiliary materials include the following raw materials in parts by weight: 1.3 parts of suspending agent, 1 part of sunscreen agent, 0.8 parts of pH regulator, 1.2 parts of emulsifier, 43 parts of foaming agent, 0.5 parts of flavor, and 1.6 parts of thickener.

[0091] The preparation method of the above lotion product comprises:

[0092] (1) adding a suspending agent, a sunscreen, a thickener and a pH regulator into deionized water, wherein the total weight of the suspending agent, the sunscreen, the thickener and the pH regulator and the solid-liquid ratio of the deionized water is 1:100 g / mL, and ultrasonically treating the mixture at 55° C. and 300 rpm for 25 min to obtain an aqueous phase I;

[0093] (2) adding a foaming agent to deionized water at a solid-liquid ratio of 1:30-50 g / mL, ultrasonically treating the mixture at 55° C. and 300 rpm for 20 min, adding the composite selenium disulfide composition, and continuing stirring for 25 min to obtain an aqueous phase II;

[0094] (3) heating the emulsifier and the flavor at 55° C. and mixing for 12 min to obtain an oil phase;

[0095] (4) Add water phase II to the oil phase and stir for 25 minutes, then add water phase I and continue stirring for 20 minutes to form a mixture, homogenize at 5500 rpm for 20 minutes, and fill to obtain a lotion product.

[0096] Comparative Application Example 4

[0097] On the basis of Application Example 1, 8 wt % of the compound selenium disulfide composition of Example 1 was replaced by the compound selenium disulfide composition of Comparative Example 1.

[0098] Comparative Application Example 5

[0099] On the basis of Application Example 1, 8 wt % of the compound selenium disulfide composition of Example 1 was replaced by the compound selenium disulfide composition of Comparative Example 2.

[0100] Comparative Application Example 6

[0101] On the basis of Application Example 1, 8 wt % of the compound selenium disulfide composition of Example 1 was replaced by the compound selenium disulfide composition of Comparative Example 3.

[0102] Test Example 1

[0103] The selenium disulfide lotion products prepared in Examples 1-3 and Comparative Application Examples 4-6 were tested for performance (properties, content, viscosity and pH value);

[0104] Determination of content: Refer to the determination method of selenium disulfide lotion products in the "Chinese Pharmacopoeia" (2020 edition).

[0105] Determination of viscosity: Selenium disulfide lotion product was placed in an IQ rheometer, with rotor model C35, gap of 0.1 mm, CR mode, and shear rate γ = 100.0 s -1 The viscosity was measured using a rotational viscometer under the conditions of scanning time t = 2 min and temperature T = 25°C.

[0106] Determination of pH value: refer to the pH determination method in the "Chinese Pharmacopoeia" (2020 edition).

[0107] The results are shown in Table 1.

[0108] Table 1

[0109]

[0110] It can be seen from Table 1 that all indicators of application examples 1-3 and comparative application examples 4-6 meet the required standards.

[0111] Test Example 2

[0112] 1. The high temperature stability and low temperature stability of the selenium disulfide lotion products prepared in Examples 1-3 and Comparative Application Examples 4-6 were observed. The specific method is as follows:

[0113] 1. High temperature stability: Place the selenium disulfide lotion product at 40°C for 48 hours, then return it to 25°C and observe whether the product is stratified;

[0114] 2. Low temperature stability: Place the selenium disulfide lotion product at -8°C for 48 hours, then return to 25°C and observe whether the product is stratified;

[0115] The results are shown in Table 2.

[0116] Table 2

[0117]

[0118]

[0119] 2. Based on the experimental results of Example 1, the selenium disulfide lotion products corresponding to Examples 1-3 were placed in a stability test chamber for stability testing;

[0120] Specific methods: 1. Accelerated stability test: carried out at a temperature of 40°C and a relative humidity of 25%;

[0121] 2. Long-term stability study: carried out at a temperature of 25°C and a relative humidity of 40%;

[0122] 3. Intermediate condition stability test: carried out at a temperature of 30°C and a relative humidity of 35%;

[0123] The content was determined by referring to the determination method of selenium disulfide lotion in the "Chinese Pharmacopoeia" (2020 edition) as an indicator for stability investigation.

[0124] The content test results are shown in Table 3.

[0125] Table 3

[0126]

[0127] As can be seen from Table 3, the selenium disulfide lotion products prepared in Application Examples 1-3 of the present invention were subjected to accelerated, long-term and intermediate stability tests. When placed for 6 months, the selenium disulfide content remained relatively stable, indicating that the selenium disulfide lotion products prepared in Application Examples 1-3 of the present invention have good stability.

[0128] Test Example 3

[0129] The inhibitory effect of the selenium disulfide lotion products prepared by corresponding application examples 1-3 and comparative application examples 4-6 on Malassezia was tested. In addition, the compound selenium disulfide composition was replaced with a selenium disulfide lotion product prepared by adding only selenium disulfide as a control group, and the selenium disulfide lotion purchased from the market (purchased from Dayou Pharmaceutical Yangzhou Co., Ltd.) was used as a commercially available group.

[0130] The results are shown in Table 4.

[0131] Table 4

[0132] sample Malassezia inhibition rate Application Example 1 99.54％ Application Example 2 99.35％ Application Example 3 99.46％ Comparative Application Example 4 89.14％ Comparative Application Example 5 92.57％ Comparative Application Example 6 86.54％ Control group 82.97％ Commercially available group 83.11％

[0133] As can be seen from Table 4, the inhibition rates of the selenium disulfide lotion products prepared in Application Examples 1-3 of the present invention on Malassezia are all greater than 99%, which are better than the selenium disulfide lotion products of Comparative Application Examples 4-6, and are also better than the lotion products containing only selenium disulfide and the selenium disulfide lotion in the commercial group.

[0134] Test Example 4

[0135] The selenium disulfide lotion product prepared according to Example 1 and the selenium disulfide lotion of the commercial group (purchased from Dayou Pharmaceutical Yangzhou Co., Ltd.) were evaluated for their efficacy in treating dandruff, seborrheic dermatitis of the scalp and tinea versicolor;

[0136] Experimental method 1: 100 volunteers with dandruff and seborrheic dermatitis were divided into 2 groups, 50 people in each group, and the selenium disulfide lotion product prepared in Application Example 1 and the selenium disulfide lotion of the commercial group (purchased from Dayou Pharmaceutical Yangzhou Co., Ltd.) were used twice a week. After one month of use, the safety and efficacy of treating dandruff and seborrheic dermatitis were evaluated based on the volunteers' feelings;

[0137] Efficacy standards: (1) Effective: There is a significant anti-dandruff effect, scalp itching disappears, and erythema and scales disappear; (2) Poor: The anti-dandruff effect is average, scalp itching is relieved, and erythema and scales remain; (3) Ineffective: There is no change before and after use, and even severe redness, swelling, and itching may occur.

[0138] The results are shown in Table 5.

[0139] Table 5

[0140]

[0141]

[0142] As can be seen from Table 5, the selenium disulfide lotion product prepared in Application Example 1 of the present invention has a good anti-dandruff effect and is better than the commercially available group.

[0143] Experimental method 2: 100 volunteers with tinea versicolor were divided into 2 groups, 50 people in each group, and the selenium disulfide lotion product prepared in Application Example 1 and the selenium disulfide lotion of the commercial group (purchased from Dayou Pharmaceutical Yangzhou Co., Ltd.) were used twice a week. After one month of use, the effect of treating tinea versicolor lesions was observed;

[0144] Efficacy criteria: (1) cured: all clinical symptoms and signs disappear; (2) markedly effective: clinical symptoms and signs disappear ≥ 60%; (3) improved: clinical symptoms and signs disappear 20-59%; (4) ineffective: clinical symptoms and signs disappear ≤ 20% or continue to worsen. Calculate the effective rate, effective rate = (number of cured cases + number of markedly effective cases) / total number of cases × 100%, the results are shown in Table 6.

[0145] Table 6

[0146] sample Number of cases / case Recovered / case Significantly effective / case Progress / Example Invalid / Example Effectiveness / % Application Example 1 50 20 20 9 1 80 Commercially available group 50 8 20 17 5 56

[0147] As can be seen from Table 6, the selenium disulfide lotion product prepared in Application Example 1 of the present invention has a good effect in treating tinea versicolor and is better than the commercially available group.

[0148] In addition, the selenium disulfide lotion products of Examples 1-3 were tested for skin irritation, and all were found to be negative (0 points), indicating that they are non-irritating and highly safe.

[0149] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A composite selenium disulfide composition, characterized in that: According to weight parts, the raw materials include: 2-4 parts of selenium disulfide, 1-2 parts of polyvinyl alcohol, 1-3 parts of sodium alginate, 4-6 parts of polyol, and 0.5-0.7 parts of accelerator; The accelerator is betaine and chlorogenic acid in a mass ratio of 2-4:1; The polyols are propylene glycol, erythritol and sorbitol in a mass ratio of 3-5:1-3:

1.

2. The method for preparing a composite selenium disulfide composition according to claim 1, characterized in that: The specific preparation steps include: (1) adding polyvinyl alcohol and a surfactant into water and stirring with ultrasound to obtain a dispersion a; (2) adding selenium disulfide and an accelerator to dispersion a and stirring uniformly to obtain dispersion b; (3) mixing sodium alginate and polyol to obtain treated sodium alginate; (4) The treated sodium alginate and dispersion b are mixed evenly, and dried to obtain a composite selenium disulfide composition.

3. The method for preparing a composite selenium disulfide composition according to claim 2, characterized in that: In step (1), the surfactant is any one of sodium dodecyl sulfate, sodium lauryl polyoxyethylene ether sulfate or sodium stearate; The mass ratio of the polyvinyl alcohol to the surfactant is 1:0.1-0.2; the solid-liquid ratio of the polyvinyl alcohol to water is 1:50-70 g / mL; and the ultrasonic stirring is performed at 20-30 KHz and 30-40° C. for 1-3 hours.

4. Use of the composite selenium disulfide composition according to claim 1 in the preparation of a lotion product.

5. The use according to claim 4, characterized in that The lotion product comprises 5-10 wt% of the compounded selenium disulfide composition and 90-95 wt% of auxiliary materials.

6. The use according to claim 5, characterized in that The auxiliary materials include the following raw materials in parts by weight: 1.1-1.3 parts of suspending agent, 0.9-1 parts of sunscreen, 0.7-0.8 parts of pH regulator, 1.1-1.2 parts of emulsifier, 41-43 parts of foaming agent, 0.4-0.5 parts of flavor, and 1.5-1.6 parts of thickener.

7. The use according to claim 6, characterized in that The pH regulator is citric acid and sodium dihydrogen phosphate dihydrate in a mass ratio of 1-3:1; the foaming agent is lauryl sulfate monoethanolamine salt and dodecyl-tetradecyl dimethyl betaine in a mass ratio of 35-40:

1.

8. The use according to claim 5, characterized in that The preparation method of the lotion product comprises: (1) adding a suspending agent, a sunscreen, a thickener and a pH adjuster into deionized water and performing ultrasonic treatment to obtain an aqueous phase I; (2) adding a foaming agent into deionized water, ultrasonically treating the water, adding the composite selenium disulfide composition, and continuing to stir to obtain an aqueous phase II; (3) heating and mixing the emulsifier and the flavor to obtain an oil phase; (4) Adding water phase II to the oil phase and stirring, then adding water phase I and continuing to stir to form a mixture, homogenizing, and filling to obtain a lotion product.

9. The use according to claim 8, characterized in that In step (1), the solid-liquid ratio of the total mass of the suspending agent, the opacifying agent, the thickener and the pH adjusting agent to deionized water is 1:80-100 g / mL; the temperature of the ultrasonic treatment is 45-55° C., the time is 15-25 min, and the speed is 200-300 rpm; In step (2), the solid-liquid ratio of the foaming agent to deionized water is 1:30-50 g / mL; the temperature of the ultrasonic treatment is 45-55° C., the time is 10-20 min, and the speed is 200-300 rpm; and the stirring time is 15-25 min.

10. The use according to claim 8, characterized in that In step (3), the heating, mixing and stirring is carried out at 45-55° C. for 8-12 minutes; In step (4), the stirring time is 15-25 min; the continued stirring time is 10-20 min; the homogenization speed is 4500-5500 rpm, and the time is 10-20 min.

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