Preparation method of Kaixin pills
By improving the dosage form of Kaixinsan, it is prepared into Kaixinsan with good taste, and adopting ultra-high temperature sterilization and multiple crushing and mixing steps, the problems of traditional Kaixinsan's poor taste and poor compliance are solved, achieving the convenience of taking pills and the retention of active ingredients.
Patent Information
- Application Number
- CN202510000634.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-01-02
- Publication Date
- 2025-04-01
AI Technical Summary
The poor taste and poor clinical compliance of traditional Kaixinsan lead to certain usage disorders in actual applications.
By improving the dosage form, Kaixin Pills are prepared into pills, and the powder is processed using an ultra-high temperature instantaneous sterilizer, and pills with good taste are formed through multiple steps such as pulverization, mixing, water addition, molding, drying and polishing.
The taste of Kaixin Pills has improved, which increases the convenience of taking patients. At the same time, the effective ingredients of the medicinal materials are retained through high-temperature sterilization, improving the efficacy of the pills.
Smart Images
Figure CN119732920A_ABST
Abstract
Description
Technical Field
[0001] The invention relates to a method for preparing a traditional Chinese medicine preparation, in particular to a method for preparing Kaixin pills. Background Art
[0002] In the Tang Dynasty, Sun Simiao's "Prescriptions for Emergencies" recorded the Chinese medicine prescription of Kaixin Powder, which has the effects of calming the mind, replenishing qi, removing dampness and clearing turbidity. It is mainly used to treat the syndrome of insufficient heart qi, with symptoms such as restlessness, forgetfulness, insomnia, palpitations, etc. It is mainly composed of Chinese medicinal materials such as ginseng, Poria, Polygala, and Acorus calamus. At present, modern equipment and methods have been used to prepare Kaixin Powder, but the powder has disadvantages such as poor taste and poor clinical compliance. Summary of the invention
[0003] In order to solve the shortcomings of traditional Kaixin powder such as poor taste and poor clinical compliance, the present invention improves the dosage form based on the powder, aiming to provide a method for preparing Kaixin pills with good taste and easy to take.
[0004] The preparation method of Kaixin pills in the present scheme comprises the following steps: a, taking 1-2 parts of ginseng, 1-2 parts of Polygala, 2-4 parts of Poria and 1-2 parts of Acorus calamus by weight, selecting and crushing them into coarse powder respectively; b, putting the coarse powder into an ultra-high temperature instantaneous sterilizer respectively, with a sterilization temperature of 140-200 degrees and a sterilization time of 5-30 seconds, collecting the sterilized powders respectively and setting them aside; c, mixing the sterilized powders, crushing them again, passing through a sieve and mixing them again; d, adding 60-95% purified water of the weight of the powder to the qualified powders after the above mixing, mixing them thoroughly, refining them 1-3 times to obtain a soft material for setting aside; (70-90% purified water) e, passing the soft material through a pill making machine to make primary pills for setting aside; f, putting the primary pills into a dryer for drying, shaping the pills and selecting qualified pills; g, adding the qualified pills into a coating pot, adding polishing liquid for polishing, selecting the pills and obtaining finished pills.
[0005] Furthermore, in step a, the powder is crushed into coarse powder with a particle size of 1-8 mm.
[0006] Furthermore, in step b, the sterilization temperature is 150-180 degrees and the sterilization time is 5-20 seconds.
[0007] Furthermore, in step c, the mesh size of the sieve is 80-120 meshes, and the mixing time is 10-30 minutes.
[0008] Furthermore, in the step d, the mass of purified water added is 70-90% of the mass of the medicinal powder, and the mass of molding auxiliary materials is 1-5% of the mass of the medicinal powder.
[0009] Furthermore, in the step e, a double-roller pill-making machine or an automatic pill-making machine is used to make pills by a plastic method to prepare the primary pills.
[0010] Furthermore, in the step f, the primary pellets are put into a dryer and dried to a moisture content of 4-8%.
[0011] Furthermore, in step g, the polishing liquid is purified water or sucrose water at 1-3% of the mass of the pills, and the polishing time is 25-80 minutes.
[0012] Furthermore, the molding auxiliary material is honey or maltose or starch.
[0013] Furthermore, in the step f, a tunnel dryer or a microwave dryer is used for drying.
[0014] The invention has the advantages that the Kaixin pills are made into pills through a series of dosage form reforms on the basis of powders, have good taste and are easy to take. The raw material medicine powder adopts an ultra-high temperature instantaneous sterilizer, and the effective ingredients can also be retained. BRIEF DESCRIPTION OF THE DRAWINGS
[0015] Figure 1 The present invention is a process flow chart of the preparation method of Kaixin pills. DETAILED DESCRIPTION
[0016] The present invention is further described in detail below with reference to the accompanying drawings and specific embodiments:
[0017] according to Figure 1 As shown, this scheme provides a method for preparing happy pills, comprising the following steps:
[0018] a. Clean and crush: Take 1-2 parts of ginseng, 1-2 parts of Polygala, 2-4 parts of Poria, and 1-2 parts of Acorus calamus by weight, clean and crush them into coarse powder respectively; in this embodiment, take 1 part of ginseng, 1 part of Polygala, 2 parts of Poria, and 1 part of Acorus calamus by weight, and crush them into coarse powder with a particle size of 1-8 mm.
[0019] b. Sterilization: The coarse powder is placed in an ultra-high temperature instantaneous sterilizer at a sterilization temperature of 140-200 degrees for 5-30 seconds, and the sterilized powder is collected for standby use; in this embodiment, the sterilization temperature is preferably 150-180 degrees and the sterilization time is preferably 5-20 seconds. This sterilization method can preserve the effective ingredients of the medicinal materials.
[0020] c. Crushing and mixing: the sterilized powders are mixed, crushed again, passed through a sieve, and mixed again; in this embodiment, the mesh size of the sieve is 80-120 meshes, and the mixing time is 10-30 minutes.
[0021] d. Mixing and refining: Add 60-95% purified water of the mass of the powder to the qualified mixed powder, mix thoroughly, and refining 1-3 times to obtain a soft material for standby use; (70-90% purified water) In this embodiment, the mass of purified water added is 70-90% of the mass of the powder, and 1-5% of the mass of the powder is added to form auxiliary materials.
[0022] e. Preparing primary pills: passing the soft material through a pill making machine to prepare primary pills for standby use; in this embodiment, a double-roller pill making machine or an automatic pill making machine is used to prepare the primary pills by a plastic method. Preferably, a double-roller pill making machine is used, and the integrity and roundness of the primary pills are better.
[0023] f. Drying and screening: The primary pills are put into a dryer for drying, granulation, and screening of qualified pills; in this embodiment, a tunnel dryer or a microwave dryer is used for drying. The primary pills are put into the dryer for drying to a moisture content of 4-8%, preferably 4-6%, and more preferably 5%. Such a drying and drying treatment method increases the dissolution time limit of the pills.
[0024] g, finished pills: add the qualified pills into the coating pan, add polishing liquid and polishing agent for polishing, the polishing liquid is 1-3% of the pills mass of purified water or sucrose water, the polishing time is 25-80 minutes, the polishing time is preferably 30-60 minutes, more preferably 50 minutes, the polishing agent is insect wax, and the sucrose water with a density of 1.0-1.1g / ml is selected as the polishing liquid, and polishing increases the brightness of the pills. Select the pills to get the finished pills.
[0025] As a further improvement of this embodiment, the molding auxiliary material can be selected from honey, maltose or starch.
[0026] The above is only an embodiment of the present invention, and the common knowledge such as the known specific structure and characteristics in the scheme is not described in detail here. It should be pointed out that for those skilled in the art, several modifications and improvements can be made without departing from the structure of the present invention, which should also be regarded as the protection scope of the present invention, and these will not affect the effect of the implementation of the present invention and the practicality of the patent.
Claims
1. A method for preparing Kaixin pills, characterized in that: The following steps are involved: a. Take 1-2 parts of ginseng, 1-2 parts of polygala, 2-4 parts of poria and 1-2 parts of calamus by weight, select them, and grind them into coarse powder respectively; b. Place the coarse powder into an ultra-high temperature instantaneous sterilizer at a sterilization temperature of 140-200 degrees for 5-30 seconds, and collect the sterilized powders for later use; c. mixing the sterilized drug powders, crushing them again, sieving them, and mixing them again; d. Add 60-95% purified water to the above mixed qualified powder, mix thoroughly, and refine 1-3 times to obtain a soft material for later use; (70-90% purified water) e. passing the soft material through a pelletizing machine to form primary pellets for later use; f. Put the primary pills into a dryer for drying, refining, and selecting qualified pills; g. Add the qualified pills into the coating pan, add polishing liquid to polish, select the pills, and obtain the finished pills.
2. The method for preparing the happy pills according to claim 1, characterized in that: In the step a, the powder is crushed into coarse powder with a particle size of 1-8 mm.
3. The method for preparing the happy pills according to claim 1, characterized in that: In the step b, the sterilization temperature is 150-180 degrees and the sterilization time is 5-20 seconds.
4. The method for preparing the happy pills according to claim 1, characterized in that: In the step c, the mesh size of the sieve is 80-120 meshes, and the mixing time is 10-30 minutes.
5. The method for preparing the happy pills according to claim 1, characterized in that: In the step d, the mass of purified water added is 70-90% of the mass of the medicinal powder, and the mass of molding auxiliary materials is 1-5% of the mass of the medicinal powder.
6. The method for preparing the happy pills according to claim 1, characterized in that: In the step e, a double-roller pill-making machine or an automatic pill-making machine is used to make pills by a plastic method to prepare the primary pills.
7. The method for preparing the happy pills according to claim 1, characterized in that: In the step f, the primary pellets are put into a dryer and dried to a moisture content of 4-8%.
8. The method for preparing the happy pills according to claim 1, characterized in that: In the step g, the polishing liquid is purified water or sucrose water at 1-3% of the mass of the pills, and the polishing time is 25-80 minutes.
9. The method for preparing the happy pills according to claim 5, characterized in that: The molding auxiliary material is honey or maltose or starch.
10. The method for preparing the happy pills according to claim 1, characterized in that: In the step f, the drying process is carried out in a tunnel dryer or a microwave dryer.