CuTA-por epsilon-pl nano platform, preparation method and application thereof
By preparing the CuTA-Por@ε-PL nanoplatform, the problems of ROS oxidative stress and biofilm penetration and diffusion difficulties in the treatment of peri-implantitis by antibacterial photodynamic therapy were solved, achieving efficient removal of biofilm and regulation of inflammation, thus improving the therapeutic effect of PI.
Patent Information
- Application Number
- CN202411952996.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-27
- Publication Date
- 2026-06-23
- Estimated Expiration
- 2044-12-27
AI Technical Summary
Current antibacterial photodynamic therapy for the treatment of peri-implantitis suffers from limitations in efficacy due to issues such as ROS-induced tissue oxidative stress, lack of biomembrane-specific targeting capability, and difficulty in biomembrane penetration and diffusion.
Using the CuTA-Por@ε-PL nanoplatform, protoporphyrin was grafted and ε-polylysine was encapsulated via amidation to form CuTA-Por@ε-PL nanoparticles. The positive charge on their surface enhanced the biomembrane penetration ability, and ROS was generated through aPDT to clear biomembranes and regulate inflammation.
It enhances the penetration and distribution of nanoparticles within biomembranes, clears ROS within PI tissues, inhibits inflammatory responses, promotes tissue regeneration, and provides a more effective PI treatment method.