Sanitary insecticide composition containing cyprodinil and method for controlling sanitary pests

Abstract

The present invention belongs to the technical field of sanitary insecticides, and in particular to a sanitary insecticide composition containing cyproflumizone and a method for controlling sanitary pests. The present invention finds that compounding the lethal agent cyproflumizone with the knockdown agent tetraflumethrin / Es-bioallethrin has an excellent knockdown and lethal effect for sanitary pests (especially mosquitoes and flies), and is particularly beneficial for controlling pyrethroid-resistant mosquitoes and flies. Moreover, the above-mentioned compounding has a significant synergistic effect, can reduce the amount of insecticides used and delay resistance, and is beneficial to pest resistance management.

Description

Technical Field

[0001] The invention belongs to the technical field of sanitary insecticides, and in particular relates to a sanitary insecticide composition containing cyprodinil and a method for preventing and controlling sanitary pests. Background Art

[0002] Dengue fever is an acute infectious disease caused by dengue virus, which is mainly transmitted by mosquitoes. It is mostly prevalent in tropical and subtropical regions. Typical symptoms include persistent fever, headache, muscle pain, joint pain, etc., and in severe cases it can be fatal.

[0003] Mosquitoes can not only spread dengue fever, but also malaria, epidemic encephalitis B, lymphatic filariasis, etc. In addition to mosquitoes, other common health pests, such as flies, fleas, ticks, midges, gnats, etc., are mostly vectors and can spread diseases.

[0004] When a vector-borne disease breaks out in the early stages, especially mosquito-borne diseases such as dengue fever, the most important means of control is to quickly kill the adults, while treating the breeding grounds to kill the larvae, quickly cutting off the transmission chain, and controlling further outbreaks of the disease. In order to quickly knock down and kill the adults, sanitary insecticides that are compounded with knockdown agents and lethal agents are currently mainly used, and control methods such as spraying, ultra-low volume spraying, and / or thermal fog spraying are used. Among them, knockdown agents generally use pyrethroid insecticides with good knockdown effects, such as tetrafluthrin, Es-bioallethrin, etc., while lethal agents generally use pyrethroids with good lethal effects. However, with the long-term and large-scale use of pyrethroid lethal agents, vectors have developed varying degrees of resistance to them, and the control effect has become increasingly poor. There is an urgent need to screen lethal agents that are different from the existing mechanism of action for resistance management and to rotate agents.

[0005] Cyproflanilide is a diamide insecticide developed by Nantong Taihe Chemical Co., Ltd. It is an allosteric modulator of γ-aminobutyric acid (GABA)-gated chloride ion channels and a member of IRAC Group 30. Cyproflanilide has a broad insecticide spectrum, is highly effective, low in toxicity, is environmentally friendly, and has no cross-resistance with existing insecticides.

[0006] Prior art CN201910704042.6 and CN202280080877.9 disclose the application of compound compositions of cyflumizone and cypermethrin and cypermethrin, etc., which are lethal agents of the pyrethroid class, on agricultural pests or German cockroaches. However, compound compositions of cyflumizone and cypermethrin and cypermethrin, etc., which are lethal agents of the pyrethroid class, have poor knockdown properties and are not suitable for space spraying to quickly kill vectors. Summary of the invention

[0007] The first object of the present invention is to provide a sanitary insecticide composition, which comprises an active ingredient A and an active ingredient B; wherein the active ingredient A is cyprodinil; and the active ingredient B is selected from at least one of tetrafluthrin and Es-bioallethrin.

[0008] The second object of the present invention is to provide a method for controlling sanitary pests, which comprises: applying the insecticide composition to the sanitary pests or their living environment.

[0009] The present invention has found in a large number of experiments that the compounding of the lethal agent cyfluthrin and the knockdown agent tetrafluthrin / Es-bioallethrin has an excellent knockdown and lethal effect on sanitary pests (especially mosquitoes and flies), and is particularly beneficial for preventing and controlling pyrethroid-resistant mosquitoes and flies. Moreover, the compounding has a significant synergistic effect, can reduce the amount of insecticides used and delay resistance.

[0010] At the same time, the sanitary insecticide composition of the present invention has the characteristics of low toxicity, high efficiency and environmental protection. It is suitable for use in the health field to prevent and control harmful organisms. It can be used as a rotating agent to quickly control vector-borne diseases (such as dengue fever, etc.). It adds a new type of compound composition that can delay the drug resistance of pests and is beneficial to the management of pest resistance. DETAILED DESCRIPTION

[0011] The specific embodiments of the present invention are described in detail below. It should be understood that the specific embodiments described herein are only used to illustrate and explain the present invention, and are not used to limit the present invention. Those skilled in the art may make various modifications and changes to the present invention without departing from the scope or spirit of the present invention. For example, a feature described or illustrated as part of one embodiment may be used in another embodiment to produce a further embodiment.

[0012] Unless otherwise indicated, the meaning of all terms (including technical and scientific terms) used to disclose the present invention is the same as that commonly understood by those of ordinary skill in the art to which the present invention belongs. By way of further guidance, the following definitions are used to better understand the teachings of the present invention. The terms used herein in the specification of the present invention are only for the purpose of describing specific embodiments and are not intended to limit the present invention.

[0013] The terms "and / or", "or / and", and "and / or" used in this article include any one of two or more related listed items, and also include any and all combinations of related listed items, and the arbitrary and all combinations include any two related listed items, any more related listed items, or a combination of all related listed items. It should be noted that when at least three items are connected by at least two conjunctions selected from "and / or", "or / and", and "and / or", it should be understood that in this application, the technical solution undoubtedly includes technical solutions that are all connected by "logical and", and undoubtedly includes technical solutions that are all connected by "logical or". For example, "A and / or B" includes three parallel solutions of A, B and A+B. For example, the technical solution of "A, and / or, B, and / or, C, and / or, D" includes any one of A, B, C, and D (that is, the technical solution that is all connected by "logical OR"), and also includes any and all combinations of A, B, C, and D, that is, the combination of any two or any three of A, B, C, and D, and also includes the combination of four of A, B, C, and D (that is, the technical solution that is all connected by "logical AND").

[0014] As used herein, the terms "comprising", "including" and "comprising" are synonymous and are inclusive or open-ended and do not exclude additional, unrecited members, elements or method steps.

[0015] Numerical ranges expressed as endpoints herein include all numbers and fractions subsumed within the range, as well as the recited endpoints.

[0016] The present invention relates to concentration values, and its meaning includes fluctuations within a certain range. For example, it can fluctuate within the corresponding accuracy range. For example, 2% can allow fluctuations within the range of ±0.1%. For values ​​that are large or do not require too fine control, its meaning is also allowed to include greater fluctuations. For example, 100mM can allow fluctuations within the range of ±1%, ±2%, ±5%, etc. Involving molecular weight, its meaning is allowed to include fluctuations of ±10%.

[0017] In the present invention, descriptions such as "plurality" and "multiple" refer to quantities greater than or equal to 2 unless otherwise specified.

[0018] In the present invention, the technical features described in an open manner include closed technical solutions composed of the listed features, and also include open technical solutions containing the listed features.

[0019] In the present invention, “preferred”, “better”, “more preferred” and “suitable” are only used to describe implementation methods or examples with better effects. It should be understood that they do not constitute limitations on the scope of protection of the present invention.

[0020] In the present invention, "optionally", "optional", "optionally", "optionally", "optional", "optional", "optional" means optional, that is, it means to be selected from any one of the two parallel schemes of "yes" or "no". If multiple "optional" or "optional" appear in a technical solution, unless otherwise specified and there is no contradiction or mutual restriction, each "optional" or "optional" is independent.

[0021] The present invention first provides a sanitary insecticide composition, which comprises an active ingredient A and an active ingredient B; wherein the active ingredient A is cyprodinil; and the active ingredient B is selected from at least one of cyfluthrin and Es-bioallethrin.

[0022] The present invention unexpectedly discovered in a large number of tests that the active ingredient A and the active ingredient B have a synergistic effect after being compounded, which can greatly improve the knockdown and lethal effects on sanitary pests, and is particularly beneficial for controlling pyrethroid-resistant mosquitoes and flies, and can reduce the amount of insecticides used and delay resistance.

[0023] In some embodiments, the active ingredient B is transfluthrin or Es-bioallethrin. In some embodiments, the active ingredient B is a mixture of transfluthrin and Es-bioallethrin.

[0024] The present invention also finds that after optimizing the weight ratio of active ingredient A to active ingredient B, the synergistic effect can be further enhanced. In this regard, the present invention further proposes the following implementation scheme regarding the weight ratio.

[0025] In some embodiments, the weight ratio of the active ingredient A to the active ingredient B is 20:1 to 1:1, more preferably 10:1 to 2:1.

[0026] In some specific embodiments, the weight ratio of the active ingredient A to the active ingredient B can be 20:1, 15:1, 12:1, 10:1, 8:1, 5:1, 3:1, 2:1, 1:1, or any value within the range of 20:1 to 1:1.

[0027] In some embodiments, the weight ratio of cyfluthrin to tetrafluthrin is 20:1 to 1:1, more preferably 10:1 to 5:1.

[0028] In some specific embodiments, the weight ratio of cyfluthrin to tetrafluthrin can be 20:1, 15:1, 12:1, 10:1, 8:1, 6:1, 5:1, 3:1, 1:1, or any value within the range of 20:1 to 1:1.

[0029] In some embodiments, the weight ratio of ciprofloxacin to Es-bioallethrin is 20:1 to 1:1, more preferably 5:1 to 2:1.

[0030] In some specific embodiments, the weight ratio of ciprofloxacin to Es-bioallethrin is 20:1, 15:1, 10:1, 7:1, 5:1, 4:1, 3:1, 2:1, 1:1, or any value within the range of 20:1 to 1:1.

[0031] In some embodiments, the sum of the contents of active ingredient A and active ingredient B is 1% to 40% of the total weight of the sanitary insecticide composition, preferably 2% to 30%, more preferably 2% to 25%, more preferably 3% to 20%, more preferably 3% to 15%, more preferably 4% to 10%, and more preferably 5% to 10%.

[0032] In some specific embodiments, the sum of the contents of active ingredient A and active ingredient B can be 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 12%, 15%, 17%, 20%, 25%, 30%, 35%, 40%, or any value in the range of 1% to 40% of the total weight of the sanitary insecticide composition.

[0033] The sanitary insecticide composition of the present invention can be prepared into a dosage form permitted by sanitary insecticides, such as being prepared into a dosage form permitted by sanitary insecticides by combining it with auxiliary components of pesticide preparations.

[0034] In some embodiments, the dosage form of the sanitary insecticide composition is emulsifiable concentrate, microemulsion, soluble solution, aqueous emulsion, suspoemulsion, suspension, microcapsule suspension, wettable powder, or water dispersible granules.

[0035] In some embodiments, the dosage form is an emulsifiable concentrate, a microemulsion, an aqueous emulsion, a suspension, or a wettable powder.

[0036] In some embodiments, the sanitary insecticide composition further comprises a carrier and / or an adjuvant.

[0037] In some embodiments, the carrier is selected from one or more of water, solvent, and filler.

[0038] In some embodiments, the auxiliary agent is selected from one or more of a wetting agent, a dispersant, an emulsifier, a disintegrant, an antifreeze agent, a preservative, a defoaming agent, a thickener, an acid-base regulator, and a binder.

[0039] In some embodiments, the solvent is selected from one or more of C6-C30 isoparaffin or dearomatized solvent oil, methyl laurate, diethyl maleate, tributyl phosphate and other low-toxic and odorless monoester, diester or triester solvents, diisooctyl phthalate, trans-2-hexenol, diesel, 150# solvent oil, diisopropyl diacid, dimethylformamide, N,N-dimethylacetamide, N,N-dimethylpropionamide, N,N-dimethylcaprylamide, dimethyl phthalate, vegetable oil, engine oil and dimethyl sulfoxide.

[0040] In some embodiments, the filler is selected from one or more of kaolin, white carbon black, clay, bentonite, attapulgite, diatomaceous earth and light calcium.

[0041] In some embodiments, the wetting agent is selected from one or more of fatty alcohol polyoxyethylene ether, alkylphenol polyoxyethylene ether, alkyl sulfate, naphthalene sulfonate, alkyl succinate sulfonate and alkylphenol polyoxyethylene ether formaldehyde condensate sulfonate.

[0042] In some embodiments, the dispersant is selected from one or more of polyether phosphates and salts thereof, alkylphenol polyoxyethylene ether formaldehyde condensate sulfonates, alkylphenol polyoxyethylene ether phosphates, sodium lignin sulfonate, polycarboxylates, block polyethers, phenethylphenol polyoxyethylene ether phosphate triethanolamine salts, naphthalene sulfonate formaldehyde condensates, pull-opening powder, NNO, MF and IS dispersing.

[0043] In some embodiments, the emulsifier is selected from one or more of polyether phosphate or salt, T-60, Ningru 33# (styrene phenol formaldehyde resin polyoxyethylene-polyoxypropylene block polyether), calcium dodecylbenzene sulfonate, ethylene oxide propylene oxide block copolymer, fatty alcohol polyoxyethylene ether, castor oil polyoxyethylene ether, alkylphenol polyoxyethylene ether, alkylphenol polyoxyethylene ether phosphate, alkylbenzene calcium sulfonate and block polyether.

[0044] In some embodiments, the disintegrant is selected from one or more of ammonium sulfate, sodium sulfate, glucose, corn starch, ammonium chloride, bentonite, urea and sodium bicarbonate.

[0045] In some embodiments, the antifreeze agent is selected from one or more of ethylene glycol, propylene glycol, glycerol, sodium chloride, urea, cellosolve, sorbitol, polyvinyl pyrrolidone and calcium chloride.

[0046] In some embodiments, the preservative is selected from one or more of sodium benzoate, potassium sorbate, sodium dehydroacetate, sodium diacetate, casper, paraben or its sodium salt, bronopol, pentylene glycol and sodium salicylate.

[0047] In some embodiments, the defoaming agent is selected from one or more of organosilicon compounds, lower alcohols, silicone oils, phosphate esters and fatty acid esters.

[0048] In some embodiments, the thickener is selected from xanthan gum, fumed SiO 2 , bentonite, aluminum stearate, dragon gum powder, polyvinyl alcohol, modified cellulose, magnesium aluminum silicate, gum arabic, gum, gelatin, guar gum, alginic acid, agar and tall oil.

[0049] In some embodiments, the acid-base regulator is selected from one or more of citric acid, oxalic acid, ammonium chloride, tartaric acid and succinic acid.

[0050] In some embodiments, the binder is selected from one or more of polyvinyl pyrrolidone, sodium carboxymethyl cellulose, methyl cellulose, polyvinyl alcohol, dextrin, sodium alginate, sodium alginate, and calcium lignosulfonate.

[0051] In specific implementation, the carriers and adjuvants that can be used in the sanitary insecticide composition of the present invention include but are not limited to the components mentioned above. Those skilled in the art can combine the above embodiments with common sense to obtain more specific embodiments of the sanitary insecticide composition of the present invention.

[0052] The present invention does not particularly limit the preparation method of the sanitary insecticide composition. The insect repellent composition can be obtained by mixing the components involved based on common knowledge in the art.

[0053] The present invention also provides a method for controlling sanitary pests, which comprises: applying the sanitary pest killing composition to the sanitary pests or their living environment.

[0054] In some embodiments, the sanitary pests include one or more of mosquitoes, flies, cockroaches, bedbugs, fleas, lice, ticks, mites, midges, gnats, and horseflies; preferably, the sanitary pests are one or two of mosquitoes and flies. The sanitary insecticide composition of the present invention has a better control effect on the above-mentioned sanitary pests, especially mosquitoes and flies.

[0055] Furthermore, the sanitary mosquitoes include but are not limited to Culex pipiens pallens, Culex pipiens quinquefasciatus, Aedes albopictus, Aedes aegypti, Culex pipiens harassing, Culex pipiens minutus, Culex tritaeniorhynchus, Anopheles gambiae, Anopheles minimus, Anopheles dire, Anopheles stephensi, Anopheles sinensis, and Anopheles anthropophagus.

[0056] Furthermore, the sanitary flies include but are not limited to house flies, stable flies, silky green flies, bright green flies, big-headed ropes, brown-tailed hemp ropes, copper green flies, summer toilet flies, and toilet flies.

[0057] In some embodiments, the sanitary pests are resistant to pyrethroids. The sanitary insecticide composition of the present invention still has a good control effect on sanitary pests that are already resistant to pyrethroids. In some preferred embodiments, the pyrethroid is permethrin.

[0058] The living environment of sanitary pests mentioned in the present invention includes any environment where sanitary pests may appear, including corners in buildings, kitchens, bathrooms, basements, wooden structures of buildings, wooden furniture, grass, bushes, outdoor garbage dumps, etc.

[0059] In some specific embodiments, space spraying is used to control sanitary pests.

[0060] In some specific embodiments, the sanitary insecticide composition is diluted with water / kerosene by an appropriate multiple, and during the peak activity period of vectors (mosquitoes and flies), spray, ultra-low volume spray or thermal fog machine spray is used to quickly knock down and kill the vector insects, thereby cutting off the spread and diffusion of the disease as soon as possible.

[0061] Embodiments of the present invention will be described in detail below in conjunction with examples. It should be understood that these examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention. The experimental methods in the following examples that do not specify specific conditions are preferably referred to the guidance provided in the present invention, and can also be based on the experimental manual or normal conditions in this area, and can also be based on other experimental methods known in the art, or according to the conditions recommended by the manufacturer.

[0062] In the following specific embodiments, the measured parameters of raw material components may have slight deviations within the range of weighing accuracy unless otherwise specified. For temperature and time parameters, acceptable deviations caused by instrument test accuracy or operation accuracy are allowed.

[0063] Application Example 1: Determination of the co-toxicity coefficient of cyfluthrin and tetrafluthrin / Es-bioallethrin

[0064] Refer to NY / T 1154.1-2006 "Guidelines for Indoor Bioassay Tests of Pesticides Insecticides Part 1: Contact Activity Test Spot Method" and NY / T1154.7-2006 "Guidelines for Indoor Bioassay Tests of Pesticides Insecticides Part 7: Determination of Combined Action of Mixtures".

[0065] Test subjects: Culex pipiens pallens, indoor sensitive strain, female mosquitoes that did not suck blood 3-5 days after emergence.

[0066] Test agents: Weigh cyprodinil, tetrafluthrin and Es-bioallethrin technical drugs respectively, add appropriate amount of acetone to dissolve, prepare single-dose stock solution, and design 5 groups of proportions. Each single dose and each group of mixed proportions are set with 5 series of mass concentrations in equal proportions.

[0067] Experimental treatment: The test adopted the drip method. After the drip treatment, standard feeding was resumed. There were 20 female mosquitoes in each group. The test was repeated 3 times. The number of deaths was counted after 24 hours.

[0068] The co-toxicity coefficient (CTC value) of the mixture was calculated using the Sun Yunpei method.

[0069] The percentage of agent A in the mixture = agent A content / (agent A content+agent B content)×100%.

[0070] Actual toxicity index (ATI) of mixture = LC of agent A 50 / LC of mixture 50 ×100.

[0071] Theoretical toxicity index (TTI) of a mixture = TI(A) × the percentage of agent A in the mixture + TI(B) × the percentage of agent B in the mixture.

[0072] Co-toxicity coefficient (CTC) = actual toxicity index (ATI) of the mixture / theoretical toxicity index (TTI) of the mixture × 100.

[0073] A co-toxicity coefficient ≥120 indicates a synergistic effect; a co-toxicity coefficient ≤80 indicates an antagonistic effect; and a co-toxicity coefficient between 80 and 120 indicates an additive effect.

[0074] Table 1 Determination of the co-toxicity coefficient of cyfluthrin and tetrafluthrin

[0075]

[0076] Note: ng / ♀ means the amount of drug instilled per female mosquito.

[0077] According to the results in Table 1, the weight ratio of cyflumizone to cyfluthrin is 20:1 to 1:1, and the co-toxicity coefficient is greater than 100, which has a significant synergistic effect. In particular, when the ratio of cyflumizone to cyfluthrin is 10:1 to 5:1, the synergistic effect is more obvious, all above 220.

[0078] Table 2 Determination results of the co-toxicity coefficient of cyprofenamide and Es-bioallethrin

[0079]

[0080]

[0081] Note: ng / ♀ means the amount of drug instilled per female mosquito.

[0082] According to the results in Table 2, the weight ratio of ciprofloxacin to Es-bioallethrin is 20:1 to 1:1, and the co-toxicity coefficient is greater than 145, which has a significant synergistic effect. In particular, when the ratio of ciprofloxacin to Es-bioallethrin is 5:1 to 2:1, the synergistic effect is more obvious, all above 180.

[0083] Formulation Example 1: 6% cyprodinil / tetrafluthrin emulsifiable concentrate (5:1)

[0084] 5 g of cyprodinil original drug, 1 g of tetrafluthrin original drug, 2 g of calcium dodecylbenzenesulfonate, 6 g of Ningru 33#, 2 g of castor oil polyoxyethylene ether (EL-40), and N,N-dimethylacetamide were added to make up to 100 g to prepare emulsifiable concentrate preparation Example 1.

[0085] Formulation Example 2: 6% cyprodinil / tetrafluthrin emulsion in water (10:1)

[0086] 5.455 g of cyprodinil technical drug, 0.545 g of tetrafluthrin technical drug, 6 g of N,N-dimethylcaprylamide, 5 g of alkylphenol polyoxyethylene ether phosphate, 2 g of castor oil polyoxyethylene ether (EL-40), 2 g of calcium dodecylbenzene sulfonate, 5 g of ethylene glycol, and water were added to make up to 100 g to prepare aqueous emulsion preparation Example 2.

[0087] Formulation Example 3: 6% cyprodinil.Es-bioallethrin microemulsion (5:1)

[0088] Microemulsion Preparation Example 3 was prepared by adding 5 g of cyprodinil technical drug, 1 g of Es-bioallethrin technical drug, 2 g of fatty alcohol polyoxyethylene ether (AEO-9), 17 g of castor oil polyoxyethylene ether (EL-40), and dimethylformamide to make up to 100 g.

[0089] Formulation Example 4: 6% cyprodinil.Es-bioallethrin wettable powder (2:1)

[0090] 4 g of cyprosulfuron technical drug, 2 g of Es-bioallethrin technical drug, 3 g of white carbon black, 3 g of sodium dodecyl sulfate, 7 g of sodium lignin sulfonate, 0.3 g of citric acid, and kaolin were added to make up to 100.0 g to prepare wettable powder formulation Example 4.

[0091] Comparative Example 1: 6% cyprodinil emulsifiable concentrate

[0092] Comparative Example 1 was prepared by adding 6 g of cyprodinil original drug, 2 g of calcium dodecylbenzenesulfonate, 6 g of Ningru 33#, 2 g of castor oil polyoxyethylene ether (EL-40), and N,N-dimethylacetamide to make up to 100 g.

[0093] Comparative Example 2: 6% cyprodinil / cypermethrin emulsifiable concentrate (5:1)

[0094] Comparative Example 2 was prepared by adding 5 g of cyprodinil original drug, 1 g of cypermethrin original drug, 2 g of calcium dodecylbenzenesulfonate, 6 g of Ningru 33#, 2 g of castor oil polyoxyethylene ether (EL-40), and N,N-dimethylacetamide to 100 g.

[0095] Comparative Example 3: 6% cyprodinil-isothiazolin emulsifiable concentrate (5:1)

[0096] Comparative Example 3 was prepared by adding 5 g of cyprodinil technical drug, 1 g of ethoprolin technical drug, 2 g of calcium dodecylbenzenesulfonate, 6 g of Ningru 33#, 2 g of castor oil polyoxyethylene ether (EL-40), and N,N-dimethylacetamide to make up to 100 g.

[0097] Comparative Example 4: 6% Permethrin EC

[0098] Emulsifiable concentrate preparation Comparative Example 4 was prepared by adding 6 g of permethrin original drug, 4 g of calcium dodecylbenzene sulfonate, 6 g of fatty alcohol polyoxyethylene ether (AEO-9), and 150# solvent oil to make up to 100 g.

[0099] Comparative Example 5: 6% Permethrin. Transfluthrin Emulsion in Water (5:1)

[0100] 5 g of permethrin technical, 1 g of transfluthrin technical, 6 g of N,N-dimethyl decanoic acid amide, 5 g of alkylphenol polyoxyethylene ether phosphate (FS-3000), 2 g of castor oil polyoxyethylene ether (EL-40), 2 g of calcium dodecylbenzene sulfonate, 5 g of ethylene glycol, and water were added to make up to 100 g to prepare an aqueous emulsion preparation comparative example 5.

[0101] Comparative Example 6: 6% Permethrin-Permethrin EC (5:1)

[0102] Emulsifiable concentrate preparation comparison example 6 was prepared by adding 5 g of permethrin technical, 1 g of tetrafluoromethoxythrin technical, 2 g of calcium dodecylbenzenesulfonate, 6 g of Ningru 33#, 2 g of castor oil polyoxyethylene ether (EL-40), and N,N-dimethylacetamide to make up to 100 g.

[0103] Application Example 2: Indoor efficacy test on mosquitoes and flies

[0104] Test method: Refer to GB / T13919.1-2009 Indoor efficacy test and evaluation of public health insecticides for pesticide registration, spray.

[0105] Test subjects: Culex pipiens pallens, indoor sensitive strain; Housefly, indoor sensitive strain.

[0106] Test treatment: mosquito test preparation dosage 40mg / m3 , diluted 50 times with water, the dosage of fly test preparation is 80mg / m 3 Cylinder spray, 50 times diluted with water, 30 heads per group, repeated 3 times, counted the number of knockdowns within 20 minutes, the test insects were restored to standard feeding, and the number of deaths was counted after 24 hours.

[0107] Table 3 Example preparation mosquito and fly indoor efficacy test results

[0108]

[0109] According to the results in Table 3, the knockdown activity of the lethal agents ciprofloxacin and permethrin against mosquitoes and flies is very poor. After being combined with the knockdown agent, the knockdown activity of the combined preparations against mosquitoes and flies is significantly improved compared with the lethal single agent, and the mortality rate is also improved compared with the lethal single agent, with obvious synergy. However, when ciprofloxacin is combined with the lethal agents cypermethrin and ethomethrin, the knockdown activity is very poor, and the mortality rate is not significantly improved.

[0110] Application Example 3: Aedes albopictus efficacy test

[0111] Test method: Refer to GB / T13919.1-2009 Indoor efficacy test and evaluation of public health insecticides for pesticide registration, spray method.

[0112] Test subjects: Eggs and larvae of Aedes albopictus were collected outdoors and reared in the laboratory to establish a population. The test insects were female mosquitoes that had not sucked blood on the 3rd to 5th day after emergence.

[0113] Test treatment: Test preparation dosage 80mg / m 3 , diluted 50 times with water, sprayed in a cylinder, 30 heads per group, repeated 3 times, counted the number of knockdowns within 20 minutes, the test insects were restored to standard feeding, and the number of deaths was counted after 24 hours.

[0114] Table 4 Example preparations Aedes albopictus outdoor strain efficacy test results

[0115] serial number Example Formulations <![CDATA[KT 50 / min]]> 24-hour mortality rate Preparation Example 1 6% cyprodinil.tetrafluthrin EC (5:1) 5.91 97.8％ Preparation Example 3 6% cyprodinil.Es-bioallethrin microemulsion (5:1) 7.73 90％ Comparative Example 1 6% cyprodinil suspending agent / 64.4％ Comparative Example 2 6% cypermethrin-cypermethrin EC (5:1) / 62.2％ Comparative Example 3 6% cyprodinil-isothiazolin EC (5:1) / 67.8％ Comparative Example 4 6% Permethrin EC / 33.3％ Comparative Example 5 6% Permethrin-Transfluthrin Emulsion in Water (2:1) 11.21 43.3％ Comparative Example 6 6% Permethrin-Permethrin Emulsion in Water (2:1) 9.15 51.1％

[0116] According to the results in Table 4, the compound preparation of cyfluthrin and transfluthrin / Es-bioallethrin can control permethrin-resistant mosquitoes, and the knockdown rate and 24h mortality rate are significantly better than those of the compound preparation of permethrin and transfluthrin / transfluthrin.

[0117] The sanitary composition of the present invention can be used as a rotating agent for the permethrin compound preparation to control pyrethroid-resistant vectors, providing a new type of agent for rapid control of vector-borne diseases (such as dengue fever, etc.), and has a synergistic effect, reduces the dosage of insecticides, delays the resistance of sanitary pests, and reduces the environmental load.

[0118] The above-mentioned embodiments only express several implementation methods of the present invention, and the description is relatively specific and detailed, but it cannot be understood as limiting the scope of the invention patent. It should be pointed out that for ordinary technicians in this field, several modifications and improvements can be made without departing from the concept of the present invention, which all belong to the protection scope of the present invention.

Claims

1. A sanitary insecticide composition comprising active ingredient A and active ingredient B; in, The active ingredient A is cyprodinil; The active ingredient B is selected from at least one of cyfluthrin and Es-bioallethrin.

2. The sanitary insecticidal composition according to claim 1, wherein The weight ratio of the active ingredient A to the active ingredient B is 20:1 to 1:1, more preferably 10:1 to 2:

1.

3. The sanitary insecticidal composition according to claim 1, wherein The weight ratio of cyfluthrin to tetrafluthrin is 20:1 to 1:1, more preferably 10:1 to 5:

1.

4. The sanitary insecticidal composition according to claim 1, wherein The weight ratio of ciprofloxacin to Es-bioallethrin is 20:1 to 1:1, more preferably 5:1 to 2:

1.

5. The sanitary insecticidal composition according to any one of claims 1 to 4, wherein The sum of the contents of active ingredient A and active ingredient B is 1% to 40% of the total weight of the sanitary insecticide composition, preferably 3% to 15%.

6. The sanitary insecticidal composition according to any one of claims 1 to 5, wherein The dosage form of the sanitary insecticide composition is emulsifiable concentrate, microemulsion, soluble agent, emulsion in water, suspoemulsion, suspension, microcapsule suspension, wettable powder, or water dispersible granules; preferably, the dosage form is emulsifiable concentrate, microemulsion, emulsion in water, suspension, or wettable powder.

7. The sanitary insecticidal composition according to claim 6, wherein The sanitary insecticide composition also includes a carrier and / or an adjuvant; Wherein, the carrier is selected from one or more of water, solvent, and filler; The auxiliary agent is selected from one or more of a wetting agent, a dispersant, an emulsifier, a disintegrant, an antifreeze agent, a preservative, a defoaming agent, a thickener, an acid-base regulator, and a binder.

8. A method for controlling sanitary pests, comprising: The sanitary insecticide composition according to any one of claims 1 to 7 is applied to the sanitary pests or their living environment.

9. The method for controlling sanitary pests according to claim 8, wherein: The sanitary pests include one or more of mosquitoes, flies, cockroaches, bedbugs, fleas, lice, ticks, mites, midges, gnats and horseflies; preferably, the sanitary pests are one or two of mosquitoes and flies.

10. The method for controlling sanitary pests according to claim 8 or 9, wherein: The sanitary pests are resistant to pyrethroids; preferably, the pyrethroids are permethrin.

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