Nutritional composition for osteoporotic fracture recovery and preparation method thereof

Abstract

The invention discloses a nutritional composition for osteoporotic fracture recovery and a preparation method thereof, and relates to the field of food / health care products. The composition for osteoporotic fracture recovery is prepared from the following components in parts by weight: 600 to 900 parts of oligomeric collagen peptide, 300 to 600 parts of small molecular oyster peptide, 100 to 300 parts of fish oil extract, 100 to 300 parts of calcium beta-hydroxy-beta-methyl butyrate, 100 to 150 parts of fructo-oligosaccharide, 60 to 90 parts of L-carnitine, 20 to 50 parts of gamma-aminobutyric acid, 10 to 30 parts of calcium aspartate and 3 to 4 parts of taurine. According to the composition for recovering the osteoporotic fracture, provided by the invention, a nutritional and healthy food suitable for recovering the osteoporotic fracture of the old people is formulated aiming at the conditions of constipation, chewing and swallowing conditions, mouth feel, compliance and the like of the osteoporotic fracture of the old people, especially bedridden patients, and various nutrients are combined according to a specific ratio; the traditional Chinese medicine composition is beneficial to accelerating body recovery of patients, preventing muscle attenuation, subsequently improving sclerotin and muscle strength for a long time, and reducing the risk of cardiovascular diseases at the same time.

Description

Technical Field

[0001] The present invention belongs to the field of food / health food, and specifically relates to a nutritional composition and a preparation method thereof, which is used for the recovery of osteoporotic fracture patients by combining multiple nutrients to exert synergistic regulatory effects. Background Art

[0002] The most serious consequence of osteoporosis is fragility fracture, which can cause severe pain and severe disability.

[0003] Elderly patients with osteoporotic fractures face a serious problem of postoperative refractures, which are affected by multiple factors such as bone quality, dysfunction of the affected limb, decreased neuromuscular function of the lower limbs due to advanced age, abnormal gait, decreased reaction and balance ability, and underlying diseases. Long-term use of osteoporosis drugs has side effects. For example, the patent with publication number CN113712953B invented a pharmaceutical composition for rapid healing of osteoporotic fractures, which adds bisphosphonates, trimebutine maleate and other drugs. Long-term use may cause side effects such as muscle pain, indigestion, and difficulty swallowing pain. Therefore, the market prospects for developing nutritious and healthy foods that help patients recover after surgery and improve bone quality and muscle strength in the long term are broad. Summary of the invention

[0004] The purpose of the present invention is to provide a nutritional composition for the recovery of osteoporotic fractures, and another purpose is to provide a method for preparing the nutritional composition for the recovery of osteoporotic fractures. Aiming at the nutritional needs of elderly patients with osteoporotic fractures for postoperative body recovery and improvement of osteoporosis, while taking into account the constipation, chewing and swallowing conditions, taste and compliance of elderly osteoporotic patients, especially bedridden patients, a nutritious and healthy food suitable for the recovery of osteoporotic fracture patients is formulated in a targeted manner, which plays a synergistic regulatory role through a combination of multiple nutrients, helps to accelerate the recovery of the patient's body and prevent muscle attenuation.

[0005] To achieve the above object, the present invention provides the following technical solutions: A nutritional composition for osteoporotic fracture recovery comprises the following components: 600-900 parts of oligocollagen peptide, 300-600 parts of small molecule oyster peptide and 100-300 parts of fish oil extract.

[0006] The nutritional composition for osteoporotic fracture recovery also includes 100-300 parts of calcium β-hydroxy-β-methylbutyrate, 100-150 parts of oligofructose, 60-90 parts of L-carnitine, 20-50 parts of γ-aminobutyric acid, 10-30 parts of calcium aspartate, and 3-4 parts of taurine.

[0007] Preferably, a nutritional composition for recovery of osteoporotic fractures comprises the following components: 900 parts of oligocollagen peptides, 600 parts of small molecule oyster peptides, 300 parts of fish oil extract, 300 parts of calcium β-hydroxy-β-methylbutyrate, 150 parts of oligofructose, 90 parts of L-carnitine, 50 parts of γ-aminobutyric acid, 30 parts of calcium aspartate, and 4 parts of taurine.

[0008] The ratio of the oligocollagen peptide to the fish oil extract is 2:1-9:1.

[0009] The oligocollagen peptides are derived from fish skin and fish bones, and collagen peptides with a molecular weight of less than 1000 Da account for more than 70%.

[0010] Preferably, collagen peptides with a molecular weight of less than 1000 Da account for 77.48% of the oligocollagen peptides.

[0011] The molecular weight of the small molecule oyster peptide is less than 1000Da.

[0012] The fish oil extract is one of 18 / 12 type, 36 / 24 type and 70 / 10 type, and the content of EPA+DHA is ≥30%.

[0013] The nutritional composition for recovery of osteoporotic fractures is applied to foods and health products for preventing and improving osteoporosis.

[0014] Oligomeric collagen peptides are derived from fish skin, fish bones, etc., and are rich in glutamic acid, glycine, alanine, proline, etc. They have good osteogenic activity and can significantly promote osteoblast proliferation, differentiation and mineralization. In the range of 20-200 μg / mL, they can significantly promote the proliferation activity of MC3T3-E1 osteoblasts, which is helpful for bone formation in the body; they can also promote the absorption and transport of calcium ions by intestinal epithelial cells and improve the bioavailability of calcium in the body; they have good antioxidant activity and free radical scavenging ability, and the antioxidant ability increases with the increase of concentration. It is beneficial to protect the intestinal barrier of the body and improve immunity.

[0015] Oyster peptides have significant antioxidant, immunomodulatory and anti-fatigue activities, and are effective in preventing sarcopenia and delaying kidney aging. Small molecule oyster peptides are easily absorbed to exert their biological activity.

[0016] Calcium β-hydroxy-β-methylbutyrate can effectively promote the body's skeletal muscle protein synthesis, slow down muscle protein decomposition, increase muscle strength and endurance, and help improve the muscle mass of fracture patients, especially bedridden patients; at the same time, it has a high calcium content, which synergistically exerts a calcium supplement effect.

[0017] Oligofructose can effectively promote the proliferation of beneficial intestinal bacteria, regulate the body's intestinal flora, and improve problems such as weakened intestinal function and constipation in the elderly, especially bedridden patients.

[0018] Fish oil extract, EPA+DHA content ≥30%, can be 18 / 12 type, 36 / 24 type, 70 / 10 type. Fish oil extract can significantly improve muscle attenuation and blood lipid levels in the elderly, increase skeletal muscle mass in the elderly, improve the ability of muscle protein synthesis in the elderly, and improve muscle function; help reduce the risk of cardiovascular disease, reduce the occurrence of chronic inflammation, help relieve pain and swelling, and have a positive effect on coronary heart disease, hyperlipidemia, hypertension and inflammation.

[0019] L-carnitine improves the fat metabolism environment in the elderly, reduces the body's inflammatory response level, and helps control infection.

[0020] Taurine plays an important role in resisting oxidative stress, enhancing the body's immunity, improving nerve conduction, and improving memory and cognitive function in the elderly.

[0021] γ-aminobutyric acid has the effects of calming nerves, relieving anxiety, lowering blood pressure, and improving brain activity. It helps relieve anxiety in elderly patients with fractures, especially bedridden patients.

[0022] Calcium aspartate has high calcium bioavailability and can help replenish calcium in the body.

[0023] The combination of oligocollagen peptides, small molecule oyster peptides and fish oil extracts can significantly improve skeletal muscle atrophy in the elderly, inhibit protein decomposition, promote protein synthesis and muscle regeneration, and effectively inhibit the production of osteoclasts, thereby helping to maintain the mineralization balance and structural integrity of bones and improve skeletal muscle oxidative stress and inflammatory status. Fish oil extracts, L-carnitine and taurine can better stabilize the body's glucose and lipid metabolism and control the occurrence and development of metabolic complications.

[0024] The present invention also provides another technical solution: A method for preparing a nutritional composition for osteoporotic fracture recovery comprises the following steps: S1: Weigh oligofructose, L-carnitine, γ-aminobutyric acid, calcium aspartate, and taurine according to the formula ratio, and premix them using a three-dimensional mixer with the loading amount being 60-80% of the maximum volume to obtain a premix; S2: Weigh oligocollagen peptides, small molecule oyster peptides, calcium β-hydroxy-β-methylbutyrate, fish oil extract and premix according to the formula ratio, add them into a lifting hopper mixer for mixing and stirring, and take out the materials after sufficient mixing to obtain a nutritional composition.

[0025] The rotation speed of the three-dimensional mixer in S1 is 2-4 r / min, and the stirring time is 8-12 min.

[0026] The speed of the lifting hopper mixer in S2 is 5-10 r / min, and the stirring time is 12-15 min.

[0027] Therefore, the present invention has the following beneficial effects: (1) The combination of multiple nutrients plays a synergistic regulatory role, which helps to accelerate the recovery of osteoporosis patients, improve skeletal muscle oxidative stress and inflammation, and prevent muscle attenuation.

[0028] (2) Adding a specific ratio of oligosaccharide fish collagen peptides has good osteogenic activity, which can significantly promote the proliferation, differentiation and mineralization of osteoblasts, and contribute to the body's bone formation; secondly, it promotes the absorption and transport of calcium ions by small intestinal epithelial cells, which is beneficial to protecting the body's intestinal barrier and improving immunity.

[0029] (3) Small molecule oyster peptides have a small molecular weight and are easily absorbed, which can prevent sarcopenia and delay kidney aging.

[0030] (4) Fish oil extract can significantly improve muscle attenuation and blood lipid levels in the elderly, increase skeletal muscle mass, improve the ability of muscle protein synthesis in the elderly, improve muscle function, and reduce the risk of cardiovascular disease. DETAILED DESCRIPTION

[0031] Example 1 A nutritional composition for recovery of osteoporotic fractures, comprising the following components: 600 parts of oligocollagen peptides, 300 parts of small molecule oyster peptides, 100 parts of calcium β-hydroxy-β-methylbutyrate, 100 parts of fish oil extract, 100 parts of oligofructose, 60 parts of L-carnitine, 20 parts of γ-aminobutyric acid, 10 parts of calcium aspartate, and 3 parts of taurine.

[0032] A method for preparing a nutritional composition for osteoporotic fracture recovery comprises the following steps: S1: Weigh 100 parts of oligofructose, 60 parts of L-carnitine, 20 parts of γ-aminobutyric acid, 10 parts of calcium aspartate, and 3 parts of taurine, and premix them in a three-dimensional mixer with a loading amount of 60% of the maximum volume, a rotation speed of 2 r / min, and mix for 10 minutes to obtain a premix; S2: Weigh 600 parts of oligocollagen peptide, 300 parts of small molecule oyster peptide, 100 parts of calcium β-hydroxy-β-methylbutyrate, 100 parts of fish oil extract and premix, add them into the lifting hopper mixer, the loading amount is 60% of the maximum volume, the speed is 5r / min, mix and stir for 12 minutes, take out the materials after sufficient mixing, and obtain a nutritional composition.

[0033] Example 2 A nutritional composition for recovery of osteoporotic fractures, comprising the following components: 600 parts of oligocollagen peptides, 300 parts of small molecule oyster peptides, 100 parts of calcium β-hydroxy-β-methylbutyrate, 300 parts of fish oil extract, 150 parts of oligofructose, 90 parts of L-carnitine, 50 parts of γ-aminobutyric acid, 30 parts of calcium aspartate, and 4 parts of taurine.

[0034] A method for preparing a nutritional composition for osteoporotic fracture recovery comprises the following steps: S1: Weigh 150 parts of oligofructose, 90 parts of L-carnitine, 50 parts of γ-aminobutyric acid, 30 parts of calcium aspartate, and 4 parts of taurine, and premix them in a three-dimensional mixer with a loading amount of 60% of the maximum volume, a rotation speed of 2 r / min, and mix for 10 minutes to obtain a premix; S2: Weigh 600 parts of oligocollagen peptide, 300 parts of small molecule oyster peptide, 100 parts of calcium β-hydroxy-β-methylbutyrate, 300 parts of fish oil extract and premix, add them into the lifting hopper mixer, the loading amount is 60% of the maximum volume, the speed is 5r / min, mix and stir for 12 minutes, take out the materials after sufficient mixing, and obtain a nutritional composition.

[0035] Example 3 A nutritional composition for recovery of osteoporotic fractures, comprising the following components: 750 parts of oligocollagen peptide, 450 parts of small molecule oyster peptide, 200 parts of calcium β-hydroxy-β-methylbutyrate, 200 parts of fish oil extract, 150 parts of oligofructose, 75 parts of L-carnitine, 35 parts of γ-aminobutyric acid, 20 parts of calcium aspartate, and 4 parts of taurine.

[0036] A method for preparing a nutritional composition for osteoporotic fracture recovery comprises the following steps: S1: Weigh 150 parts of oligofructose, 75 parts of L-carnitine, 35 parts of γ-aminobutyric acid, 20 parts of calcium aspartate, and 4 parts of taurine, and premix them in a three-dimensional mixer with a loading amount of 60% of the maximum volume, a rotation speed of 2 r / min, and mix for 10 minutes to obtain a premix; S2: Weigh 750 parts of oligocollagen peptide, 450 parts of small molecule oyster peptide, 200 parts of calcium β-hydroxy-β-methylbutyrate, 200 parts of fish oil extract and premix and add them into a lifting hopper mixer with a loading amount of 60% of the maximum volume, a rotation speed of 5r / min, mixing and stirring for 12 minutes, and taking out the materials after sufficient mixing to obtain a nutritional composition.

[0037] Example 4 A nutritional composition for recovery of osteoporotic fractures, comprising the following components: 900 parts of oligocollagen peptides, 600 parts of small molecule oyster peptides, 300 parts of calcium β-hydroxy-β-methylbutyrate, 100 parts of fish oil extract, 100 parts of oligofructose, 60 parts of L-carnitine, 20 parts of γ-aminobutyric acid, 10 parts of calcium aspartate, and 3 parts of taurine.

[0038] A method for preparing a nutritional composition for osteoporotic fracture recovery comprises the following steps: S1: Weigh 100 parts of oligofructose, 60 parts of L-carnitine, 20 parts of γ-aminobutyric acid, 10 parts of calcium aspartate, and 3 parts of taurine, and premix them in a three-dimensional mixer with a loading amount of 60% of the maximum volume, a rotation speed of 2 r / min, and mix for 10 minutes to obtain a premix; S2: Weigh 600 parts of oligocollagen peptide, 300 parts of small molecule oyster peptide, 100 parts of calcium β-hydroxy-β-methylbutyrate, 100 parts of fish oil extract and premix, add them into the lifting hopper mixer, the loading amount is 60% of the maximum volume, the speed is 5r / min, mix and stir for 12 minutes, take out the materials after sufficient mixing, and obtain a nutritional composition.

[0039] Example 5 A nutritional composition for recovery of osteoporotic fractures, comprising the following components: 600 parts of oligocollagen peptides, 300 parts of small molecule oyster peptides, 100 parts of calcium β-hydroxy-β-methylbutyrate, 300 parts of fish oil extract, 150 parts of oligofructose, 90 parts of L-carnitine, 50 parts of γ-aminobutyric acid, 30 parts of calcium aspartate, and 4 parts of taurine.

[0040] A method for preparing a nutritional composition for osteoporotic fracture recovery comprises the following steps: S1: Weigh 150 parts of oligofructose, 90 parts of L-carnitine, 50 parts of γ-aminobutyric acid, 30 parts of calcium aspartate, and 4 parts of taurine, and premix them in a three-dimensional mixer with a loading amount of 60% of the maximum volume, a rotation speed of 2 r / min, and mix for 10 minutes to obtain a premix; S2: Weigh 600 parts of oligocollagen peptide, 300 parts of small molecule oyster peptide, 100 parts of calcium β-hydroxy-β-methylbutyrate, 300 parts of fish oil extract and premix, add them into the lifting hopper mixer, the loading amount is 60% of the maximum volume, the speed is 5r / min, mix and stir for 12 minutes, take out the materials after sufficient mixing, and obtain a nutritional composition.

[0041] Comparative Example 1 A nutritional composition for recovery of osteoporotic fractures comprises the following components: 100 parts of calcium β-hydroxy-β-methylbutyrate, 100 parts of oligofructose, 60 parts of L-carnitine, 20 parts of γ-aminobutyric acid, 10 parts of calcium aspartate and 3 parts of taurine.

[0042] The specific implementation of this comparative example is the same as that of Example 1, except that, in this comparative example, no oligocollagen peptide, small molecule oyster peptide and fish oil extract are added, and the other conditions are the same as those of Example 1.

[0043] Comparative Example 2 A nutritional composition for recovery of osteoporotic fractures comprises the following components: 600 parts of oligocollagen peptides, 300 parts of small molecule oyster peptides, 100 parts of calcium β-hydroxy-β-methylbutyrate, 100 parts of oligofructose, 20 parts of γ-aminobutyric acid and 10 parts of calcium aspartate.

[0044] The specific implementation of this comparative example is the same as that of Example 1, except that, in this comparative example, no fish oil extract, L-carnitine and taurine are added, and the other conditions are the same as those of Example 1.

[0045] Comparative Example 3 A nutritional composition for recovery of osteoporotic fractures comprises the following components: 300 parts of fish oil extract, 100 parts of oligofructose, 90 parts of L-carnitine, 20 parts of gamma-aminobutyric acid and 3 parts of taurine.

[0046] A method for preparing a nutritional composition for osteoporotic fracture recovery comprises the following steps: S1: Weigh 100 parts of oligofructose, 90 parts of L-carnitine, 20 parts of γ-aminobutyric acid, and 3 parts of taurine, and pre-mix them in a three-dimensional mixer with a loading amount of 60% of the maximum volume, a rotation speed of 2 r / min, and mix for 10 minutes to obtain a premix; S2: Weigh 300 portions of fish oil extract and premix and add them into a lifting hopper mixer, with the loading amount being 60% of the maximum volume, the rotation speed being 5 r / min, mixing and stirring for 12 minutes, and taking out the materials after being fully mixed to obtain a nutritional composition.

[0047] Table 1 Raw material components in Examples 1-5 and Comparative Examples 1-3.

[0048] Effect test 1. Experimental Content (1) Experimental subjects

[0049] SAMP6 mice are a fast-aging model mouse that can well reproduce the pathological changes of senile osteoporosis, such as low bone density, low peak bone mass, and bone microstructural degradation. SAMP6 mice reach a peak bone mass at 4 months of age, and then gradually lose bone mass. This change is the same between males and females, which is similar to the pathological changes in patients with senile osteoporosis. SAMP6 mice are genetically stable, and their bone aging characteristics are similar to those of human senile osteoporosis. They can replicate the occurrence and development of senile osteoporosis from the macro to the micro level.

[0050] (2) Experimental methods The rapidly aging SAMP6 mice were used as an osteoporosis model in the elderly to evaluate the effect of the embodiments in improving osteoporosis in the elderly.

[0051] After one week of adaptive feeding, the mice were randomly divided into 9 groups, including the model group, embodiment groups 1-5 and comparative groups 1-3; the same-age anti-rapid aging SAMP1 mice were used as the normal group. The normal group and the model group were gavaged with sterile water, and the embodiment group and the comparative group were gavaged with the corresponding samples, with a gavage dose of 2.5 g / kg, and were fed continuously for 9 weeks. During the experiment, the mice had free access to water and food.

[0052] The mice were fasted for 12 hours after the last administration. Blood was collected from the heart of the mice after anesthesia. The soleus and gastrocnemius muscles on both sides of the mice were separated and weighed. The femurs and tibias on both sides of the mice were separated, wrapped with medical gauze soaked in saline, and stored at -80°C.

[0053] 2. Serum bone metabolism biochemical index test The levels of calcium, bone specific alkaline phosphatase (BALP), osteocalcin (OCN), tartrate-resistant acid phosphatase (TRACP) and C-terminal telopeptide of type I collagen (CTX-I) in mouse serum were detected. The results are shown in Table 2.

[0054] Serum calcium content, bone alkaline phosphatase (BALP) and osteocalcin (OCN) are markers of bone formation, which can reflect the state of calcium metabolism, the proliferation activity of osteocytes, and the status of bone formation and bone turnover.

[0055] Tartrate-resistant acid phosphatase 5b (TRACP5b) is a biochemical marker of bone turnover secreted by osteoclasts. It can reflect the state of bone resorption and can be used for osteoclast quantity detection, anti-bone resorption therapy detection, osteoporosis diagnosis, fracture risk prediction and bone metastasis disease detection.

[0056] CTX-I is a collagen degradation product, and its level can reflect the state of bone metabolism. When bone tissue is damaged, collagen is degraded and CTX-I is released, and the level of CTX-I in the blood increases. The increase in CTX-I level can be used as an early diagnostic indicator for osteoporosis and bone diseases and a reference marker for evaluating the effect of treatment.

[0057] CTX-Ⅰ and TRACP are bone resorption markers, and their increased levels can reflect increased bone resorption and increased fracture risk.

[0058] Table 2 Effects of different groups on bone metabolism-related indices in mice.

[0059] As shown in Table 2, compared with the normal group, the serum calcium content of the model group was lower than that of the normal group, and the serum calcium content of the Example 1-5 groups was higher than that of the model group, and the Example groups were better than the Comparative Example group. The serum calcium content of the Example 5 group was the highest, and the effect was the best, which was close to that of the normal group. This shows that the nutritional composition for osteoporotic fracture recovery containing ingredients such as oligocollagen peptides and small molecule oyster peptides can effectively promote the body's calcium absorption.

[0060] Compared with the normal group, the bone formation markers BALP and OCN in the model group were significantly reduced, and those in Example 1-5 groups were all improved compared with the model group. The example groups were all better than the control group, and the BALP and OCN in Example 5 group were the highest and the effect was the best, close to that in the normal group, indicating that the addition of the nutritional composition can effectively promote the proliferation activity of osteoblasts and contribute to bone formation in the body.

[0061] Compared with the normal group, the bone resorption markers TRACP and CTX-1 were significantly increased; after drug intervention, the TRACP and CTX-1 of the embodiment group and the control group were lower than those of the model group, and the effect of the embodiment group was better than that of the control group as a whole; and the effect of the embodiment 5 group was the best, indicating that the addition of the nutritional composition can improve the low bone turnover caused by aging and regulate the bone metabolism balance of SAMP6 mice by promoting bone formation and inhibiting bone resorption.

[0062] 3. Blood lipid content affects the test The serum total cholesterol (TC), triacylglycerol (TG), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C) in mice were detected to evaluate the effect of the embodiment on the blood lipids of mice. The test results are shown in Table 3.

[0063] LDL-C is often considered "bad cholesterol" because it plays an important role in atherosclerosis. HDL-C ("good cholesterol") helps remove cholesterol from the blood and reduces the risk of cardiovascular disease. Lowering LDL-C levels and raising HDL-C levels are two important strategies for preventing cardiovascular disease.

[0064] Table 3 Effects of different groups on blood lipid levels in mice.

[0065] As shown in Table 3, compared with the normal group, the TC, TG and LDL-C levels of the model group were significantly increased, and the HDL-C level was significantly decreased; compared with the model group, the embodiment group and the comparative example group could reduce the TC, TG and LDL-C levels, and increase the HDL-C level. The effect of the embodiment group was better than that of the comparative example group as a whole, and the effect of the embodiment 5 group was the best, indicating that the fish oil extract in the nutritional composition cooperates with other components in the composition to effectively improve the blood lipid level of the elderly.

[0066] 4. Skeletal muscle mass impact test There is a biomechanical interaction between muscle and bone, and a certain amount of muscle is required to maintain bone mass. Skeletal muscle mass index (SMI) is an indicator to measure the quality of skeletal muscle tissue. It can evaluate the basic skeletal muscle mass and reflect the nutritional status of patients. This experiment used the unilateral gastrocnemius muscle of mice, and the unilateral gastrocnemius wet weight / body weight was used to obtain the skeletal muscle mass index of mice. The test results are shown in Table 4.

[0067] Table 4 Skeletal muscle mass index (unilateral gastrocnemius wet weight / body weight) of mice in different groups.

[0068] As shown in Table 4, compared with the normal group, the skeletal muscle mass of the mice in the model group was reduced; compared with the model group, the drug administration group improved the skeletal muscle mass index to a certain extent, among which the embodiment group was better than the comparative example group as a whole, and the skeletal muscle mass index of the embodiment 5 group was the highest, with the best effect. This shows that the addition of calcium β-hydroxy-β-methylbutyrate to the nutritional composition, in conjunction with other components in the composition, effectively promotes the body's skeletal muscle protein synthesis, slows down muscle protein decomposition, increases muscle strength and endurance, is beneficial to improving the muscle mass of fracture patients, especially bedridden patients, enhances the biomechanical effect of muscle on bones, and effectively improves skeletal muscle mass.

[0069] 5. Bone density impact test The tibia bone density of mice in each group is shown in Table 5.

[0070] Table 5 Bone density of mice in different groups. Group Bone density Normal group 0.23 Model Group 0.13 Example 1 Group 0.17 Example 2 Group 0.17 Example 3 Group 0.18 Example 4 Group 0.20 Example 5 Group 0.21 Comparative Example 1 0.14 Comparative Example 2 0.15 Comparative Example 3 0.13

[0071] As shown in Table 5, compared with the normal group, the bone density of the model group was significantly reduced; the bone density of mice in the drug-treated group was higher than that of the model group; the effect of the example group was better than that of the control group, and the bone density of Example 4 and Example 5 groups was close to that of the normal group, especially Example 5 group, indicating that the nutritional composition for osteoporotic fracture recovery of the present invention has a significant effect in preventing and improving osteoporosis.

[0072] Therefore, the present invention targets the nutritional needs of elderly patients with osteoporotic fractures for postoperative body recovery and improvement of osteoporosis, while taking into account the constipation, chewing and swallowing conditions, taste and compliance of elderly patients with osteoporosis, especially bedridden patients, and specifically formulates nutritious and healthy foods suitable for the recovery of patients with osteoporotic fractures. By combining multiple nutrients in specific proportions, a synergistic regulatory effect is exerted, which helps to accelerate the patient's body recovery, prevent muscle attenuation, and subsequently improve bone quality and muscle strength in the long term, while reducing the risk of cardiovascular disease.

Claims

1. A nutritional composition for osteoporotic fracture recovery, characterized in that: Includes the following components: 600-900 parts of oligocollagen peptide, 300-600 parts of small molecule oyster peptide, 100-300 parts of fish oil extract.

2. The nutritional composition for osteoporotic fracture recovery according to claim 1, characterized in that: The invention also comprises 100-300 parts of calcium beta-hydroxy-beta-methylbutyrate, 100-150 parts of oligofructose, 60-90 parts of L-carnitine, 20-50 parts of gamma-aminobutyric acid, 10-30 parts of calcium aspartate and 3-4 parts of taurine.

3. The nutritional composition for osteoporotic fracture recovery according to claim 1 or 2, characterized in that: It includes the following components: 900 parts of oligocollagen peptide, 600 parts of small molecule oyster peptide, 300 parts of fish oil extract, 300 parts of calcium β-hydroxy-β-methylbutyrate, 150 parts of oligofructose, 90 parts of L-carnitine, 50 parts of γ-aminobutyric acid, 30 parts of calcium aspartate, and 4 parts of taurine.

4. The nutritional composition for osteoporotic fracture recovery according to claim 1, characterized in that: The ratio of the oligocollagen peptide to the fish oil extract is 2:1-9:

1.

5. The nutritional composition for osteoporotic fracture recovery according to claim 1, characterized in that: The oligocollagen peptides with a molecular weight of less than 1000Da account for more than 70% of the total mass.

6. The nutritional composition for osteoporotic fracture recovery according to claim 1, characterized in that: The molecular weight of the small molecule oyster peptide is less than 1000Da.

7. The nutritional composition for osteoporotic fracture recovery according to claim 1 or 4, characterized in that: The fish oil extract is one of 18 / 12 type, 36 / 24 type and 70 / 10 type, and the content of EPA+DHA is ≥30%.

8. A method for preparing a nutritional composition for osteoporotic fracture recovery, characterized in that: The following steps are involved: S1: oligofructose, L-carnitine, γ-aminobutyric acid, calcium aspartate, and taurine are weighed according to the formula ratio and pre-mixed in a three-dimensional mixer, with the loading amount being 60-80% of the maximum volume to obtain a premix; S2: according to the formula ratio, a certain amount of oligocollagen peptide, small molecule oyster peptide, calcium β-hydroxy-β-methylbutyrate, fish oil extract and premix are added into the lifting hopper mixer, and the loading amount is 60-80% of the maximum volume. After sufficient mixing, a nutritional composition is obtained.

9. The method for preparing the nutritional composition for osteoporotic fracture recovery according to claim 8, characterized in that: The rotation speed of the three-dimensional mixer in S1 is 2-4 r / min, and the stirring time is 8-12 min.

10. The method for preparing the nutritional composition for osteoporotic fracture recovery according to claim 8, characterized in that: The speed of the lifting hopper mixer in S2 is 5-10 r / min, and the stirring time is 12-15 min.

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