Female hair loss prevention and hair growth composition and preparation method thereof

Abstract

The invention relates to the field of functional food, in particular to a female hair loss prevention and hair growth composition and a preparation method thereof.The composition is prepared from, by weight, 20-100 parts of pea seedling extract, 10-50 parts of mulberry powder, 10-50 parts of lycium ruthenicum powder, 20-150 parts of collagen tripeptide, 20-150 parts of tea leaf theanine, 2.1-20 parts of nicotinic acid, 0.7-8.5 parts of vitamin B, 10-100 parts of maltodextrin and 200-1000 parts of sugar alcohol. And 5-15 parts of magnesium stearate. The composition is natural and healthy in component and free of side effects, has excellent hair loss preventing and hair growth promoting effects, on one hand, hair loss is prevented and hair growth is promoted from the physiological perspective of hair loss preventing, hair fixing and hair growth promoting, on the other hand, hair loss caused by emotion pressure is improved from the perspective of emotion relieving, sleep improving and endocrine balance adjusting, and the hair loss preventing and hair growth promoting effects are achieved. The problem of female alopecia can be radically solved.

Description

Technical Field

[0001] The invention relates to the field of anti-hair loss and hair growth composition, in particular to an anti-hair loss and hair growth composition for women and a preparation method thereof. Background Art

[0002] As women face increasing social and family pressures, more and more women are experiencing hair loss. Female hair loss is currently believed to be caused by the combined effects of polygenic genetic susceptibility and hormone metabolism, coupled with external factors inducing stimulation. Genetic susceptibility genes cause normal levels of androgens to bind to androgen receptors with enhanced sensitivity in hair follicle cells, leading to androgenic alopecia in women. At the same time, chronic sleep deprivation can cause an imbalance in the homeostasis of the neuro-endocrine-immune network, resulting in miniaturization of hair follicles, inflammatory damage to hair follicles, and local immune destruction, leading to hair loss. In addition, external factors such as ultraviolet rays, environmental pollutants, skin and hair follicle microorganisms (Propionibacterium, Staphylococcus, Malassezia) may cause micro-inflammation of hair follicles, which in turn causes hair follicle atrophy.

[0003] At present, there are several main ways to treat female hair loss: 1) Drug treatment, including traditional male pattern baldness treatment 5α-reductase inhibitors, spironolactone, cyproterone acetate, α-estradiol and other hormone drugs, minoxidil, etc.; 2) External means, including laser treatment, autologous platelet-rich plasma therapy, microneedle therapy, adipose-derived stem cell transplantation therapy, hair transplantation therapy, etc. Oral drug treatment is mainly hormones, which will destroy the hormone balance of the human body and have corresponding side effects; external drug treatment is generally effective, and it is easy to cause allergies and have side effects; although external means are effective, they only treat the symptoms and not the root cause. Therefore, it is urgent to develop a natural female anti-hair loss product with no side effects and good hair loss treatment effect. Summary of the invention

[0004] In order to solve the technical problems that the above-mentioned products have side effects and only treat the symptoms but not the root cause, the present invention provides a female anti-hair loss and hair growth composition and a preparation method thereof. On the one hand, it prevents hair loss and promotes hair growth from the physiological perspective of anti-hair loss, hair solidification and hair growth. On the other hand, it improves hair loss caused by emotional stress from the perspective of soothing emotions, improving sleep and regulating endocrine balance. The ingredients of the composition are natural, healthy and have no side effects, and it solves the problem of female hair loss from the root.

[0005] The specific technical scheme of the present invention is: In a first aspect, the present invention provides a female anti-hair loss and hair growth composition, the composition comprising the following raw materials in parts by weight: 20 to 100 parts of pea seedling extract, 10 to 50 parts of mulberry powder, 10 to 50 parts of black wolfberry powder, 20 to 200 parts of collagen tripeptide, 20 to 150 parts of tea theanine, 2.1 to 20 parts of niacin, 0.7 to 8.5 parts of B vitamins, 10 to 100 parts of maltodextrin, 200 to 1000 parts of sugar alcohol, and 5 to 15 parts of magnesium stearate.

[0006] The effective ingredients of the female anti-hair loss and hair growth composite formula of the present invention are composed of pea seedling extract, mulberry powder, black wolfberry powder, collagen tripeptide, tea theanine, and B vitamins. Hair can be divided into four parts from bottom to top: hair papilla, hair follicle, hair root and hair shaft. The physiological characteristics and functions of hair mainly depend on the hair papilla, hair follicle and sebaceous glands below the scalp epidermis. The growth cycle of human hair is sequentially divided into growth phase (3 to 7 years), regression phase (several weeks) and resting phase (3 months). When most of the hair stays in the resting phase, the hair growth cycle is unbalanced, and hair loss will occur. The pea seedling extract has not been lignified, contains the highest content of secondary metabolites such as adenosine, daidzin, genistein, etc., can stimulate the expression of FGF-7 gene in hair papilla cells, shorten the hair resting phase, and promote the growth of new hair.

[0007] The main component of hair is keratin. The intake of collagen peptides by the human body can supplement protein, which is beneficial to the growth of hair. However, ordinary collagen peptides have the problems of large molecular weight and low absorption rate. The collagen tripeptide used in the present invention is a small molecule peptide containing 3 amino acids prepared by advanced bioengineering technology, containing glycine, proline or hydroxyproline, plus one other amino acid, and its molecular weight is between 280 and 600 Da. Due to the presence of the peptide transporter PepT 1 in the human intestine, which can specifically transport dipeptides and tripeptides, the collagen tripeptide can be quickly absorbed by the intestine. Collagen tripeptide can effectively penetrate into the stratum corneum, dermis and hair root cells, effectively promote the proliferation of hair follicle cells, and improve hair growth.

[0008] From the perspective of traditional Chinese medicine, deficiency of essence and blood will lead to hair loss. Lycium barbarum belongs to the liver, kidney and lung meridians, and can nourish the liver and kidney, replenish deficiency and benefit essence. Black wolfberry has higher nutritional value due to its rich black fruit pigment; mulberry can replenish the yin of liver and kidney, and is used to treat liver and kidney deficiency and yin and blood deficiency. From a pharmacological perspective, mulberry and black wolfberry "use black to nourish black", contain rich anthocyanins, are natural and effective free radical scavengers, can inhibit hair follicle inflammation, and improve scalp blood microcirculation.

[0009] Tea theanine is a non-protein amino acid unique to tea. It can calm, relax, relieve stress, and improve sleep by affecting neurotransmitters. It is naturally derived and non-addictive.

[0010] B vitamins can promote the metabolism of amino acids to maintain skin health, reduce capillary wall permeability and hyaluronidase activity, reduce allergic and inflammatory reactions, and promote epithelial cell growth. They can prevent and treat seborrheic skin inflammation and thus slow down hair loss.

[0011] Preferably, the composition further comprises the following raw materials in parts by weight: 20 to 150 parts of freeze-dried powder of Lactococcus lactis WHH2078, wherein the number of viable bacteria is 1×10 8 CFU / g~1×10 10 CFU / g.

[0012] The lactococcus lactis is named WHH2078 and has been deposited in the General Microbiological Center of the China Microbiological Culture Collection Administration on February 25, 2021, at No. 3, Yard 1, Beichen West Road, Chaoyang District, Beijing, China, with a deposit number of CGMCC NO.21831. The strain can increase the content of gamma-aminobutyric acid (GABA) in the nerve center, serum and colon, and improve sleep.

[0013] The present invention finds that under the joint action of Lactococcus lactis WHH2078 and tea theanine, the two can cooperate with each other to produce a synergistic effect of "1+1>2", better improve sleep, and further improve hair loss caused by emotional stress. When the two work together, theanine can promote the production of neurotransmitter GABA in the brain, and Lactococcus lactis WHH2078 further increases the supply of GABA. Through the complex factors of the metabolic activity of Lactococcus lactis WHH2078 itself and the regulation of the proportion of intestinal flora, the biological activity and stability of theanine can be improved, and its sedative and tranquilizing effect can be enhanced, thereby better improving sleep.

[0014] Preferably, the B vitamins are at least one of vitamin B1, vitamin B2, vitamin B6, vitamin B7 and vitamin B12.

[0015] Preferably, the composition comprises the following components in parts by weight: the composition comprises the following raw materials in parts by weight: 40-60 parts of pea seedling extract, 30-40 parts of mulberry powder, 30-40 parts of black wolfberry powder, 50-100 parts of collagen tripeptide, 50-60 parts of tea theanine, 5-10 parts of niacin, 0.2-4 parts of vitamin B1, 0.2-2 parts of vitamin B2, 0.2-2 parts of vitamin B6, 0.0004-0.004 parts of vitamin B12, 0.0045-0.05 parts of vitamin B7, 10-30 parts of maltodextrin, 500-700 parts of sugar alcohol, 50-60 parts of freeze-dried powder of Lactococcus lactis WHH2078 strain, and 5-15 parts of magnesium stearate.

[0016] Preferably, the composition comprises the following components in parts by weight: 0.5 to 1.5 parts by weight of vitamin B1, 0.5 to 1.5 parts by weight of vitamin B2, 0.5 to 1.5 parts by weight of vitamin B6, 0.01 to 0.03 parts by weight of vitamin B7, and 0.001 to 0.003 parts by weight of vitamin B12. Preferably, the sugar alcohol is at least one of maltitol, sorbitol, xylitol and erythritol.

[0017] In a second aspect, the present invention provides a method for preparing the female anti-hair loss and hair growth composition, comprising the following steps: 1) sieving all raw materials except magnesium stearate; 2) mixing the sieved raw material with magnesium stearate to obtain a mixed material; 3) Compress the mixture into tablets.

[0018] Preferably, in step 1), the mesh size is 30 to 40.

[0019] Preferably, in step 2), the mixing conditions are: mixing speed 20-40 rpm, mixing time 20-40 min.

[0020] Preferably, in step 3), the tablet pressing device is a tablet press, and the main pressure during tablet pressing is 10-40 KN and the rotation speed is 15-30 rpm.

[0021] Preferably, in step (3), the relative humidity of the environment during tableting is RH≤30%.

[0022] Compared with the prior art, the present invention has the following advantages: The composition of the present invention has natural and healthy ingredients without side effects, and has excellent anti-hair loss and hair growth effects. The composition uses pea seedling extract, mulberry powder, black wolfberry powder, collagen tripeptide, tea theanine, and B vitamins as medicinal ingredients. On the one hand, it prevents hair loss and promotes hair growth from the physiological perspectives of anti-hair loss, hair fixation, and hair growth. On the other hand, it improves hair loss caused by emotional stress from the perspectives of soothing emotions, improving sleep, and regulating endocrine balance, and can solve the problem of female hair loss from the root.

[0023] The composition of the present invention also includes freeze-dried powder of Lactococcus lactis WHH2078 strain, which can cooperate with theanine in tea to produce a synergistic effect, better improve sleep, and improve hair loss caused by emotional stress. DETAILED DESCRIPTION

[0024] The present invention will be further described below in conjunction with the embodiments.

[0025] The pea sprout extract described in each embodiment of the present invention is taken from AnaGainTMNu Swiss pea sprout extract, the Lactococcus lactis WHH2078 freeze-dried powder is provided by Hangzhou Wahaha Technology Co., Ltd., and the others are all commercially available common products.

[0026] Overall embodiment The invention provides a female anti-hair loss and hair growth composition, which is prepared from the following raw materials in parts by weight: 20-100 parts of pea seedling extract, 10-50 parts of mulberry powder, 10-50 parts of black wolfberry powder, 20-200 parts of collagen tripeptide, 20-150 parts of tea theanine, 2.1-20 parts of niacin, 0.7-8.5 parts of B vitamins, 10-100 parts of maltodextrin, 200-1000 parts of sugar alcohol, and 5-15 parts of magnesium stearate.

[0027] As a specific embodiment, the composition further comprises the following raw materials in parts by weight: 20 to 150 parts of Lactococcus lactis WHH2078 freeze-dried powder, wherein the number of viable bacteria is 1×10 8 CFU / g~1×10 10 CFU / g. The B vitamins are at least one of vitamin B1, vitamin B2, vitamin B6, vitamin B7 and vitamin B12. The composition is made of the following raw materials in parts by weight: 40-60 parts of pea seedling extract, 30-40 parts of mulberry powder, 30-40 parts of black wolfberry powder, 50-100 parts of collagen tripeptide, 50-60 parts of tea theanine, 5-10 parts of niacin, 0.2-4 parts of vitamin B1, 0.2-2 parts of vitamin B2, 0.2-2 parts of vitamin B6, 0.0004-0.004 parts of vitamin B12, 0.0045-0.05 parts of vitamin B7, 10-30 parts of maltodextrin, 500-700 parts of sugar alcohol, 50-60 parts of Lactococcus lactis WHH2078 strain freeze-dried powder, and 5-15 parts of magnesium stearate. The weight portion of the vitamin B1 is 0.5 to 1.5 parts, the weight portion of the vitamin B2 is 0.5 to 1.5 parts, the weight portion of the vitamin B6 is 0.5 to 1.5 parts, the weight portion of the vitamin B7 is 0.01 to 0.03 parts, and the weight portion of the vitamin B12 is 0.001 to 0.003 parts. The sugar alcohol is at least one of maltitol, sorbitol, xylitol and erythritol.

[0028] The present invention provides a method for preparing the female anti-hair loss and hair growth composition, comprising the following steps: 1) sieving all raw materials except magnesium stearate; 2) mixing the sieved raw material with magnesium stearate to obtain a mixed material; 3) Compress the mixture into tablets.

[0029] As a specific implementation, in step 1), the mesh size is 30-40 meshes. In step 2), the mixing conditions are: mixing speed 20-40 rpm, mixing time 20-40 min. In step 3), the tableting equipment is a tablet press, and the main pressure during tableting is 10-40 KN, and the speed is 15-30 rpm. In step (3), the relative humidity of the environment during tableting is RH≤30%.

[0030] The Lactococcus lactis WHH2078 freeze-dried powder used in the present invention is prepared by a conventional freeze-dried powder preparation process. Specific embodiments The present invention is described below by specific examples. It should be understood that these examples are only used to illustrate the present invention and are not used to limit the scope of the present invention. Without departing from the spirit and scope of the inventive concept, changes and advantages that can be thought of by those skilled in the art are included in the present invention, and the attached claims and any equivalents thereof are the protection scope of the present invention.

[0032] Unless otherwise defined, all technical terms and scientific terms used in the present invention have the same meanings as those commonly understood by ordinary technicians in the field to which the present disclosure belongs. Unless otherwise specified, the raw materials and equipment used in the present invention are conventional raw materials and equipment in the field and can be obtained from conventional commercial channels; unless otherwise specified, the methods used in the present invention are conventional methods in the field.

[0033] Example 1 The present embodiment provides a female anti-hair loss and hair growth composition, which comprises the following raw materials, by weight: 50 parts of pea seedling extract, 40 parts of mulberry powder, 40 parts of black wolfberry powder, 100 parts of collagen tripeptide, 100 parts of tea theanine, 1 part of vitamin B1, 1 part of vitamin B2, 10 parts of niacin, 1 part of vitamin B6, 0.002 parts of vitamin B12, 0.02 parts of biotin (i.e., vitamin B7), 20 parts of maltodextrin, 600 parts of maltitol, and 10 parts of magnesium stearate.

[0034] The preparation method of the above-mentioned female anti-hair loss composite formula comprises the following steps: (1) Passing pea sprout extract, mulberry powder, black wolfberry powder, collagen tripeptide, tea theanine, vitamin B1, vitamin B2, vitamin B6, vitamin B7, vitamin B12, maltodextrin, and sorbitol through a 30-mesh sieve to ensure the fineness and uniformity of the raw materials; (2) Weigh the sieved pea sprout extract, mulberry powder, black wolfberry powder, collagen tripeptide, tea theanine, vitamin B1, vitamin B2, vitamin B6, vitamin B7, vitamin B12, maltodextrin, and sorbitol according to the proportion, pour them into the mixing tank of a three-dimensional mixer, add magnesium stearate, start the three-dimensional mixer for mixing, set the speed of the three-dimensional mixer to 30 rpm, and the mixing time to 30 min to obtain a mixture; (3) The uniformly mixed raw materials are sent to a tablet press for tableting. The main pressure of the tablet press is set to 20 KN and the rotation speed is set to 20 rpm to ensure the stability and efficiency of the tableting process. The relative humidity of the production environment is controlled at RH = 25% to ensure the hardness and stability of the tablets. After being pressed by the tablet press, female anti-hair loss and hair growth tablets are obtained.

[0035] Example 2 The present embodiment provides a female anti-hair loss and hair growth composition, which comprises the following raw materials, by weight: 30 parts of pea seedling extract, 15 parts of mulberry powder, 15 parts of black wolfberry powder, 50 parts of collagen tripeptide, 30 parts of tea theanine, 0.5 parts of vitamin B1, 0.5 parts of vitamin B2, 5 parts of niacin, 0.5 parts of vitamin B6, 0.001 parts of vitamin B12, 0.01 parts of biotin (i.e., vitamin B7), 50 parts of maltodextrin, 500 parts of sorbitol, and 5 parts of magnesium stearate.

[0036] The preparation method of the above-mentioned female anti-hair loss composite formula comprises the following steps: (1) Passing pea sprout extract, mulberry powder, black wolfberry powder, collagen tripeptide, tea theanine, vitamin B1, vitamin B2, vitamin B6, vitamin B7, vitamin B12, maltodextrin, and sorbitol through a 30-mesh sieve to ensure the fineness and uniformity of the raw materials; (2) Weigh the sieved pea sprout extract, mulberry powder, black wolfberry powder, collagen tripeptide, tea theanine, vitamin B1, vitamin B2, vitamin B6, vitamin B7, vitamin B12, maltodextrin, and sorbitol according to the proportion, pour them into the mixing tank of a three-dimensional mixer, add magnesium stearate, start the three-dimensional mixer for mixing, set the speed of the three-dimensional mixer to 20 rpm, and the mixing time to 40 min to obtain a mixture; (3) The uniformly mixed raw materials are sent to a tablet press for tableting. The main pressure of the tablet press is set to 15 KN and the rotation speed is set to 15 rpm to ensure the stability and efficiency of the tableting process. The relative humidity of the production environment is controlled at RH = 30% to ensure the hardness and stability of the tablets. After being pressed by the tablet press, female anti-hair loss and hair growth tablets are obtained.

[0037] Example 3 The present embodiment provides a female anti-hair loss and hair growth composition, which comprises the following raw materials, by weight: 100 parts of pea seedling extract, 50 parts of mulberry powder, 50 parts of black wolfberry powder, 200 parts of collagen tripeptide, 150 parts of tea theanine, 4 parts of vitamin B1, 2 parts of vitamin B2, 20 parts of niacin, 2 parts of vitamin B6, 0.004 parts of vitamin B12, 0.05 parts of biotin (i.e., vitamin B7), 40 parts of maltodextrin, 1000 parts of erythritol, and 15 parts of magnesium stearate.

[0038] The preparation method of the above-mentioned female anti-hair loss composite formula comprises the following steps: (1) Passing pea sprout extract, mulberry powder, black wolfberry powder, collagen tripeptide, tea theanine, vitamin B1, vitamin B2, vitamin B6, vitamin B7, vitamin B12, maltodextrin, and sorbitol through a 30-mesh sieve to ensure the fineness and uniformity of the raw materials; (2) Weigh the sieved pea sprout extract, mulberry powder, black wolfberry powder, collagen tripeptide, tea theanine, vitamin B1, vitamin B2, vitamin B6, vitamin B7, vitamin B12, maltodextrin, and sorbitol according to the proportion, pour them into the mixing tank of a three-dimensional mixer, add magnesium stearate, start the three-dimensional mixer for mixing, set the speed of the three-dimensional mixer to 30 rpm, and the mixing time to 40 min to obtain a mixture; (3) The uniformly mixed raw materials are sent to a tablet press for tableting. The main pressure of the tablet press is set to 30 KN and the rotation speed is set to 30 rpm to ensure the stability and efficiency of the tableting process. The relative humidity of the production environment is controlled at RH = 25% to ensure the hardness and stability of the tablets. After being pressed by the tablet press, female anti-hair loss and hair growth tablets are obtained.

[0039] Example 4 The present embodiment provides a female anti-hair loss and hair growth composition, which comprises the following raw materials, by weight: 40 parts of pea seedling extract, 40 parts of mulberry powder, 30 parts of black wolfberry powder, 50 parts of collagen tripeptide, 60 parts of tea theanine, 2 parts of vitamin B1, 0.5 parts of vitamin B2, 5 parts of niacin, 0.5 parts of vitamin B6, 0.001 parts of vitamin B12, 0.01 parts of biotin (i.e., vitamin B7), 20 parts of maltodextrin, 600 parts of maltitol, and 5 parts of magnesium stearate.

[0040] The preparation method of the above-mentioned female anti-hair loss composite formula comprises the following steps: (1) Passing pea sprout extract, mulberry powder, black wolfberry powder, collagen tripeptide, tea theanine, vitamin B1, vitamin B2, vitamin B6, vitamin B7, vitamin B12, maltodextrin, and sorbitol through a 30-mesh sieve to ensure the fineness and uniformity of the raw materials; (2) Weigh the sieved pea sprout extract, mulberry powder, black wolfberry powder, collagen tripeptide, tea theanine, vitamin B1, vitamin B2, vitamin B6, vitamin B7, vitamin B12, maltodextrin, and sorbitol according to the proportion, pour them into the mixing tank of a three-dimensional mixer, add magnesium stearate, start the three-dimensional mixer for mixing, set the speed of the three-dimensional mixer to 30 rpm, and the mixing time to 30 min to obtain a mixture; (3) The uniformly mixed raw materials are sent to a tablet press for tableting. The main pressure of the tablet press is set to 40 KN and the rotation speed is set to 20 rpm to ensure the stability and efficiency of the tableting process. The relative humidity of the production environment is controlled at RH = 25% to ensure the hardness and stability of the tablets. After being pressed by the tablet press, female anti-hair loss and hair growth tablets are obtained.

[0041] Example 5 The present embodiment provides a female anti-hair loss and hair growth composition, which comprises the following raw materials, by weight: 50 parts of freeze-dried powder of Lactococcus lactis WHH2078 strain, 100 parts of pea seedling extract, 40 parts of mulberry powder, 40 parts of black wolfberry powder, 100 parts of collagen tripeptide, 50 parts of tea theanine, 1 part of vitamin B1, 1 part of vitamin B2, 10 parts of niacin, 1 part of vitamin B6, 0.002 parts of vitamin B12, 0.02 parts of biotin (i.e., vitamin B7), 20 parts of maltodextrin, 600 parts of maltitol, and 10 parts of magnesium stearate.

[0042] The preparation method of the above-mentioned female anti-hair loss composite formula comprises the following steps: (1) Passing pea sprout extract, mulberry powder, black wolfberry powder, collagen tripeptide, tea theanine, vitamin B1, vitamin B2, vitamin B6, vitamin B7, vitamin B12, maltodextrin, and sorbitol through a 30-mesh sieve to ensure the fineness and uniformity of the raw materials; (2) weighing the sieved pea sprout extract, mulberry powder, black wolfberry powder, collagen tripeptide, tea theanine, vitamin B1, vitamin B2, vitamin B6, vitamin B7, vitamin B12, maltodextrin, sorbitol, and Lactococcus lactis WHH2078 strain freeze-dried powder according to the proportion, pouring them into a mixing tank of a three-dimensional mixer, adding magnesium stearate, starting the three-dimensional mixer for mixing, setting the three-dimensional mixer speed to 30 rpm, and the mixing time to 30 min to obtain a mixture; (3) The uniformly mixed raw materials are sent to a tablet press for tableting. The main pressure of the tablet press is set to 20 KN and the rotation speed is set to 20 rpm to ensure the stability and efficiency of the tableting process. The relative humidity of the production environment is controlled at RH = 25% to ensure the hardness and stability of the tablets. After being pressed by the tablet press, female anti-hair loss and hair growth tablets are obtained.

[0043] Example 6 The present embodiment provides a female anti-hair loss and hair growth composition, which comprises the following raw materials, by weight: 100 parts of freeze-dried powder of Lactococcus lactis WHH2078 strain, 80 parts of pea seedling extract, 30 parts of mulberry powder, 30 parts of black wolfberry powder, 150 parts of collagen tripeptide, 100 parts of tea theanine, 1 part of vitamin B1, 1 part of vitamin B2, 10 parts of niacin, 1 part of vitamin B6, 0.002 parts of vitamin B12, 0.01 parts of biotin (i.e., vitamin B7), 50 parts of maltodextrin, 500 parts of maltitol, and 10 parts of magnesium stearate.

[0044] The preparation method of the above-mentioned composite formula for preventing hair loss in women comprises the following steps: (1) Passing pea sprout extract, mulberry powder, black wolfberry powder, collagen tripeptide, tea theanine, vitamin B1, vitamin B2, vitamin B6, vitamin B7, vitamin B12, maltodextrin, and sorbitol through a 30-mesh sieve to ensure the fineness and uniformity of the raw materials; (2) weighing the sieved pea sprout extract, mulberry powder, black wolfberry powder, collagen tripeptide, tea theanine, vitamin B1, vitamin B2, vitamin B6, vitamin B7, vitamin B12, maltodextrin, sorbitol, and Lactococcus lactis WHH2078 strain freeze-dried powder according to the proportion, pouring them into a mixing tank of a three-dimensional mixer, adding magnesium stearate, starting the three-dimensional mixer for mixing, setting the speed of the three-dimensional mixer to 30 rpm, and the mixing time to 20 min to obtain a mixture; (3) The uniformly mixed raw materials are sent to a tablet press for tableting. The main pressure of the tablet press is set to 20 KN and the rotation speed is set to 20 rpm to ensure the stability and efficiency of the tableting process. The relative humidity of the production environment is controlled at RH = 25% to ensure the hardness and stability of the tablets. After being pressed by the tablet press, female anti-hair loss and hair growth tablets are obtained.

[0045] Example 7 The present embodiment provides a female anti-hair loss and hair growth composition, which comprises the following raw materials, by weight: 100 parts of freeze-dried powder of Lactococcus lactis WHH2078 strain, 50 parts of pea seedling extract, 15 parts of mulberry powder, 15 parts of black wolfberry powder, 50 parts of collagen tripeptide, 100 parts of tea theanine, 1 part of vitamin B1, 1 part of vitamin B2, 5 parts of niacin, 1 part of vitamin B6, 0.004 parts of vitamin B12, 0.02 parts of biotin (i.e., vitamin B7), 20 parts of maltodextrin, 500 parts of maltitol, and 5 parts of magnesium stearate.

[0046] The preparation method of the above-mentioned composite formula for preventing hair loss in women comprises the following steps: (1) Passing pea sprout extract, mulberry powder, black wolfberry powder, collagen tripeptide, tea theanine, vitamin B1, vitamin B2, vitamin B6, vitamin B7, vitamin B12, maltodextrin, and sorbitol through a 30-mesh sieve to ensure the fineness and uniformity of the raw materials; (2) weighing the sieved pea sprout extract, mulberry powder, black wolfberry powder, collagen tripeptide, tea theanine, vitamin B1, vitamin B2, vitamin B6, vitamin B7, vitamin B12, maltodextrin, sorbitol, and Lactococcus lactis WHH2078 strain freeze-dried powder according to the proportion, pouring them into a mixing tank of a three-dimensional mixer, adding magnesium stearate, starting the three-dimensional mixer for mixing, setting the speed of the three-dimensional mixer to 40 rpm, and the mixing time to 20 min to obtain a mixture; (3) The uniformly mixed raw materials are sent to a tablet press for tableting. The main pressure of the tablet press is set to 40 KN and the rotation speed is set to 20 rpm to ensure the stability and efficiency of the tableting process. The relative humidity of the production environment is controlled at RH = 25% to ensure the hardness and stability of the tablets. After being pressed by the tablet press, female anti-hair loss and hair growth tablets are obtained.

[0047] Comparative Example 1 The comparative example provides a female anti-hair loss and hair growth composition, which comprises the following raw materials, by weight: 50 parts of freeze-dried powder of Lactococcus lactis WHH2078 strain, 50 parts of pea seedling extract, 40 parts of mulberry powder, 40 parts of black wolfberry powder, 100 parts of collagen tripeptide, 1 part of vitamin B1, 1 part of vitamin B2, 10 parts of niacin, 1 part of vitamin B6, 0.002 parts of vitamin B12, 0.02 parts of biotin (i.e., vitamin B7), 20 parts of maltodextrin, 600 parts of maltitol, and 10 parts of magnesium stearate.

[0048] The preparation method of the above-mentioned composite formula for preventing hair loss in women comprises the following steps: (1) Passing pea sprout extract, mulberry powder, black wolfberry powder, collagen tripeptide, vitamin B1, vitamin B2, vitamin B6, vitamin B7, vitamin B12, maltodextrin, and sorbitol through a 30-mesh sieve to ensure the fineness and uniformity of the raw materials; (2) weighing the sieved pea sprout extract, mulberry powder, black wolfberry powder, collagen tripeptide, vitamin B1, vitamin B2, vitamin B6, vitamin B7, vitamin B12, maltodextrin, sorbitol, and Lactococcus lactis WHH2078 strain freeze-dried powder according to the proportion, pouring them into a mixing tank of a three-dimensional mixer, adding magnesium stearate, starting the three-dimensional mixer for mixing, setting the speed of the three-dimensional mixer to 30 rpm, and the mixing time to 30 min to obtain a mixture; (3) The uniformly mixed raw materials are sent to a tablet press for tableting. The main pressure of the tablet press is set to 20 KN and the rotation speed is set to 20 rpm to ensure the stability and efficiency of the tableting process. The relative humidity of the production environment is controlled at RH = 25% to ensure the hardness and stability of the tablets. After being pressed by the tablet press, female anti-hair loss and hair growth tablets are obtained.

[0049] Test Example 1 The purpose of this test example is to verify the anti-hair loss and hair growth effect of a female anti-hair loss and hair growth composition. The female anti-hair loss and hair growth sheet prepared in Example 1 was used for the test. The specific process is as follows: 1. Case selection (1) Subjects: This trial selected 49 women aged between 20 and 60 as subjects, including 2 women aged 21-30, accounting for about 4%; 20 women aged 31-40, accounting for about 41%; 17 women aged 41-50, accounting for about 35%; and women aged 50 and above, accounting for about 20%. This trial aims to comprehensively evaluate the effect of specific hair care products on improving hair loss problems in women of different ages. This age range covers a wide range of women from young to middle-aged women, ensuring the universality and representativeness of the trial results.

[0050] (2) Inclusion criteria: No other treatment was received within 1 month before the trial.

[0051] 2. Test process (1) Record of conditions before the test: Each subject was assessed for scalp health. The results are shown in the following table: Table 1 Hair loss status of subjects before the test Number of people Hair loss 36 Severe hair loss 8 More hair loss 4 Mild hair loss 1 Rarely hair loss As shown in Table 1, about 73% of the subjects had severe hair loss before the trial, about 17% of the subjects had more hair loss, about 8% of the subjects had slight hair loss, and about 2% of the subjects had little hair loss.

[0052] (2) Trial duration: 2 months.

[0053] (3) Treatment method: Take female anti-hair loss and hair growth tablets orally, 1 tablet each time, 3 times a day.

[0054] 3. Test results After 2 months, the subjects were revisited, and the results were as follows: 41 of the 49 subjects felt that their hair loss was significantly improved after taking the female anti-hair loss and hair growth tablets of the present invention; 3 had improved hair loss, but the effect was still not very good; 3 consumers felt that their hair loss had not changed; and 2 consumers could not describe it clearly. In the case of improved hair loss, 20 consumers had hair growing on the forehead or both sides, or felt that the amount of hair had increased.

[0055] In summary, the hair loss conditions of 89.8% of the subjects were improved, and 41% of the subjects showed hair growth effects, which proved that the composition of the present invention has a therapeutic effect on female hair loss and can promote hair growth.

[0056] Test Example 2 The purpose of this test example is to verify that Lactococcus lactis WHH2078 and tea theanine have a synergistic effect on improving sleep. The female anti-hair loss and hair growth tablets prepared in Example 1, Example 5 and Comparative Example 1 were used for the test. The specific process is as follows: 1. Case selection (1) Subjects: Thirty women aged between 20 and 40 who suffered from hair loss due to sleep disorders were selected as subjects. They were divided into three groups according to their hair loss conditions, with 10 people in each group.

[0057] (2) Inclusion criteria: No medication or psychological treatment within 1 month before the trial.

[0058] 2. Test process (1) Record of conditions before the test: Each subject was assessed for scalp health. The results are shown in the following table: Table 2 Hair loss status of subjects before the test Hair loss Group 1 Group 2 Group 3 Severe hair loss 2 people 2 people 1 person More hair loss 5 people 6 people 5 people Mild hair loss 3 people 2 people 4 people Group 1 took the female anti-hair loss and hair growth tablet prepared in Example 1, Group 2 took the female anti-hair loss and hair growth tablet prepared in Example 5, and Group 3 took the female anti-hair loss and hair growth tablet prepared in Comparative Example 1.

[0059] (2) Trial duration: 2 months.

[0060] (3) Treatment method: Take female anti-hair loss and hair growth tablets orally, 1 tablet each time, 3 times a day.

[0061] 3. Test results After 2 months, the three groups of subjects were revisited and the results were as follows: All 10 subjects in Group 1 believed that their hair loss condition had improved, and 6 of them reported that they were able to fall asleep faster or sleep longer than before; all 10 subjects in Group 2 believed that their hair loss condition had improved, and 9 of them reported that they were able to fall asleep faster or sleep longer than before; all 9 subjects in Group 3 believed that their hair loss condition had improved, and 4 of them reported that they were able to fall asleep faster or sleep longer than before.

[0062] In summary, hair loss was improved in all subjects, sleep was improved in 60% of subjects in Group 1, 90% of subjects in Group 2, and 40% of subjects in Group 3, proving that Lactococcus lactis WHH2078 and tea theanine have a synergistic effect in improving sleep.

[0063] The raw materials and equipment used in the present invention, unless otherwise specified, are all commonly used raw materials and equipment in the art; the methods used in the present invention, unless otherwise specified, are all conventional methods in the art.

[0064] The above description is only a preferred embodiment of the present invention and does not limit the present invention in any way. Any simple modification, change and equivalent transformation made to the above embodiment based on the technical essence of the present invention still falls within the protection scope of the technical solution of the present invention.

Claims

1. A female anti-hair loss and hair growth composition, characterized in that: The composition comprises the following raw materials in parts by weight: 20-100 parts of pea seedling extract, 10-50 parts of mulberry powder, 10-50 parts of black wolfberry powder, 20-200 parts of collagen tripeptide, 20-150 parts of tea theanine, 2.1-20 parts of niacin, 0.7-8.5 parts of B vitamins, 10-100 parts of maltodextrin, 200-1000 parts of sugar alcohol, and 5-15 parts of magnesium stearate.

2. A female anti-hair loss and hair growth composition according to claim 1, characterized in that: The composition further comprises the following raw materials in parts by weight: 20 to 150 parts of Lactococcus lactis WHH2078 freeze-dried powder, wherein the number of viable bacteria is 1×10 8 CFU / g~1×10 10 CFU / g.

3. A female anti-hair loss and hair growth composition according to claim 1 or 2, characterized in that: The B vitamins are at least one of vitamin B1, vitamin B2, vitamin B6, vitamin B7 and vitamin B12.

4. A female anti-hair loss and hair growth composition according to claim 3, characterized in that: The composition comprises the following raw materials in parts by weight: 40-60 parts of pea seedling extract, 30-40 parts of mulberry powder, 30-40 parts of black wolfberry powder, 50-100 parts of collagen tripeptide, 50-60 parts of tea theanine, 5-10 parts of niacin, 0.2-4 parts of vitamin B1, 0.2-2 parts of vitamin B2, 0.2-2 parts of vitamin B6, 0.0004-0.004 parts of vitamin B12, 0.0045-0.05 parts of vitamin B7, 10-30 parts of maltodextrin, 500-700 parts of sugar alcohol, 50-60 parts of Lactococcus lactis WHH2078 strain freeze-dried powder, and 5-15 parts of magnesium stearate.

5. A female anti-hair loss and hair growth composition according to claim 4, characterized in that: The weight portion of the vitamin B1 is 0.5-1.5 parts, the weight portion of the vitamin B2 is 0.5-1.5 parts, the weight portion of the vitamin B6 is 0.5-1.5 parts, the weight portion of the vitamin B7 is 0.01-0.03 parts, and the weight portion of the vitamin B12 is 0.001-0.003 parts.

6. A female anti-hair loss and hair growth composition according to claim 1, characterized in that: The sugar alcohol is at least one of maltitol, sorbitol, xylitol and erythritol.

7. A method for preparing the female anti-hair loss and hair growth composition according to any one of claims 1 to 6, characterized in that: The following steps are involved: 1) sieving all raw materials except magnesium stearate; 2) mixing the sieved raw material with magnesium stearate to obtain a mixed material; 3) Compress the mixture into tablets.

8. The method for preparing the female anti-hair loss and hair growth composition according to claim 6, characterized in that: In step 2), the mixing conditions are: mixing speed 20-40 rpm, mixing time 20-40 min.

9. The method for preparing the female anti-hair loss and hair growth composition according to claim 6, characterized in that: In step 3), the tablet pressing device is a tablet press, and the main pressure during tablet pressing is 10 to 40 kN and the rotation speed is 15 to 30 rpm.

10. The method for preparing the female anti-hair loss and hair growth composition according to claim 6, characterized in that: In step 3), the relative humidity RH of the environment during tableting is ≤30%.