Application of hemoglobin oxygen carrier in preparation of antiviral drugs

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ScRNA-seq technology reveals the antiviral mechanism of hemoglobin oxygen carriers (HBOCs) in mouse bone marrow. It is found that HBOCs can upregulate the expression of Isg15 gene, enhance the body's antiviral ability, and solve the problem that it is difficult to effectively enhance the body's antiviral ability in the prior art.

CN119746044AInactive Publication Date: 2025-04-04REDPHARM BEIJING BIOPHARMACEUTICAL INST CO LTD +1

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Patent Information

Application Number: CN202510259113.1
Authority / Receiving Office: CN · China
Patent Type: Applications(China)
Current Assignee / Owner
Filing Date: 2025-03-06
Publication Date: 2025-04-04
Estimated Expiration: Not applicable · inactive patent

Application Information

Patent Timeline

06 Mar 2025

Application

CN202510259113.1

04 Apr 2025

Publication

CN119746044A

IPC: A61K38/42; A61P31/12; A61P31/14; A61P31/20

CPC: A61K38/42; A61P31/14; A61P31/20; A61P37/04; C12Q1/6883; C12Q2600/106; C12Q2600/136; C12Q2600/158

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Application Domain

Peptide/protein ingredients Microbiological testing/measurement

Technology Topics

ISG15Antiviral drug

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AI Technical Summary

Technical Problem

The prior art is difficult to effectively enhance the body's resistance to viruses, especially when the levels of red blood cells and hemoglobin in the blood are reduced.

Method used

Through scRNA-seq technology, the mechanism of action of hemoglobin oxygen carriers (HBOCs) in mouse bone marrow was explored, and it was found that HBOCs can significantly upregulate the expression level of the antiviral gene Isg15, thereby enhancing the body's antiviral ability.

Benefits of technology

HBOCs significantly enhance the antiviral ability of immune cells in the bone marrow of mice, providing a new idea for the development and preparation of new antiviral drugs.

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Abstract

The invention relates to the technical field of biological medicine, in particular to application of hemoglobin oxygen carriers (HBOCs) in preparation of antiviral drugs. The invention provides a brand new action mechanism of the HBOCs, and reveals that the HBOCs changes immune cell subset distribution in mouse bone marrow and up-regulates the expression level of an antiviral gene Isg15, so that the resistance of a body to viruses is enhanced, and a new thought is provided for development and preparation of antiviral drugs.

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