Single magnetic piezoelectric acupuncture embedded wire and preparation method thereof

Abstract

The invention discloses a single magnetic piezoelectric acupuncture embedded wire and a preparation method thereof, and relates to the technical field of biological composite materials, the single magnetic piezoelectric acupuncture embedded wire is a wire body obtained by sequentially carrying out high-voltage electric field polarization, liquid soaking, wire drawing and drying on a dispersion liquid of a piezoelectric material and a magnetic material, wherein the liquid in the liquid soaking is water or a hydrogel material. The precursor solution is soaked in the specific liquid after the high-voltage electric field polarization treatment, the wire body material meeting the acupuncture embedded wire requirement can be pulled out, the preparation target of the single acupuncture embedded wire with the magnetic property and the piezoelectric property is achieved, the prepared acupuncture embedded wire has excellent electric signal stimulation and magnetic stimulation potential, and the application prospect is wide. And an application basis is provided for improving the curative effect of acupuncture point treatment.

Description

Technical Field

[0001] The invention relates to the technical field of biological composite materials, and in particular to a single magnetic piezoelectric acupuncture embedding thread and a preparation method thereof. Background Art

[0002] Acupuncture is an important treatment method in traditional Chinese medicine. It achieves the purpose of acupuncture therapy by implanting threads in specific acupuncture points. However, the acupuncture thread embedding currently used in clinical practice only relies on the acupuncture thread embedding to stimulate the physiological parts after being inserted into the corresponding acupuncture points (see Zhou Tianshu et al. Visual analysis of research literature on acupuncture treatment of irritable bowel syndrome from 2013 to 2023, Chinese Journal of Traditional Chinese Medicine and Information, Vol. 48, No. 6, November 2024), lacking physical signal stimulation such as electrical signal stimulation and magnetic stimulation.

[0003] Existing studies have shown that physical signal stimulation can promote cell and tissue functions. For example, Nadia et al. prepared a PVDF piezoelectric scaffold and demonstrated its promoting effect on nerve cell attachment, diffusion and proliferation (see Abzan N. et al. Development of three-dimensional piezoelectric polyvinylidene fluoride-graphene oxide scaffold by non-solvent induced phase separation method for nerve tissue engineering [J]. Materials & Design, 2019, 167.); for example, Adadi et al. developed a PVDF film, the electrical signals generated by which regulate the activity of cardiomyocyte tissue construction and induce the differentiation of human pluripotent stem cells into cardiomyocytes (see Adadi et al. Electrospun Fibrous PVDF-TrFe Scaffolds for Cardiac Tissue Engineering, Differentiation, and Maturation [J]. Advanced Materials Technologies, 2020, 5 (3).). On the other hand, magnetic stimulation of magnetic materials also has the effect of promoting cell function. For example, Wei found that magnetic Fe 3 O 4 Can induce stem cells to differentiate into osteoblasts (see Wei XL et al. Facet-dependence of Fe 3 O 4for enhancing osteogenic differentiation of BMSCs[J].Chemical Communications,2023,59(44):6742-6744.). In the actual acupuncture process, the introduction of physical signal stimulation has been proven to enhance the therapeutic effect of acupuncture. However, the current traditional acupuncture method of introducing physical signal stimulation is to apply an exogenous electric field to generate electrical signals during acupuncture, which makes the acupuncture equipment more complicated.

[0004] In order to solve the complex problems of existing acupuncture equipment with magnetic and electrical stimulation functions, it is a good research direction to use materials with piezoelectric properties and / or magnetic properties to prepare acupuncture embedded threads. Materials with piezoelectric properties can undergo charge polarization after sensing mechanical strain / stress. If materials with both magnetic properties are used to prepare acupuncture embedded threads, after the acupuncture embedded threads are inserted into the corresponding acupuncture points, the pressure exerted by human tissue on the acupuncture embedded threads can generate electrical signals, and electrical signal stimulation can be achieved without applying an external electric field. Similarly, materials with magnetic properties are used to prepare acupuncture embedded threads, which can generate magnetic stimulation when an external magnetic field is applied. By using materials with both magnetic properties and piezoelectric properties to prepare acupuncture embedded threads, acupuncture embedded threads with both electrical signal stimulation and magnetic stimulation can be obtained, greatly enhancing the acupuncture effect.

[0005] We have disclosed a biomaterial with magnetoelectric effect in the patent application document with publication number CN114566589A. The biomaterial combines an electroactive material with electric signal stimulation and piezoelectric properties with a magnetostrictive material whose scale can be extended or shortened under the stimulation of an external magnetic field, so that the composite material has both electric signal stimulation function and, under the action of an external magnetic field, the magnetostrictive material can respond to changes in the magnetic field, and its scale is extended or shortened along the magnetization direction, resulting in a magnetostrictive effect. The electroactive material undergoes potential polarization due to the magnetostrictive effect, and its piezoelectric effect is enhanced, thereby generating an electric signal. Therefore, the magnetoelectric effect biomaterial does not need to connect electrodes, wires, and an external power supply to generate electric signal stimulation in an external magnetic field. It can be seen that, in principle, if the biomaterial is used to prepare acupuncture thread embedding, it can enhance the acupuncture effect when an external magnetic field is applied or not. However, the document discloses a thin film preparation method for the biomaterial, and how to make a thread body that meets the requirements is still a major problem. Currently, 3D printing technology can use ordinary materials to load needles with a diameter of less than 1 mm at the printing end, but Feng et al. used 3D printing technology to construct Fe 3 O 4and L-polylactic acid (PLLA) magnetic and piezoelectric stents. Since the material will collapse at the beginning of construction, the actual diameter of the wire will expand, and the final shape of the material is a thin sheet with a thickness of 2 mm and a length of 15 mm (see Feng P. et al. Co-continuous structure enhanced magnetic responsive shape memory PLLA / TPU blend fabricated by 4D printing [J]. Virtual And Physical Prototyping, 2024, 19 (1): e2290186). However, according to the requirements of the "National Standard of the People's Republic of China GB2024-2016" (the maximum diameter of acupuncture thread is 0.80 mm), 3D printing technology is difficult to use to prepare acupuncture threads that meet the requirements. In addition, the method of drawing the wire after high-voltage electric field polarization is also difficult to obtain the wire material for the biomaterial mentioned in CN114566589A. Therefore, further research is needed to use the biomaterial mentioned in CN114566589A for the preparation of acupuncture threads. Summary of the invention

[0006] In view of the above problems in the prior art, the present invention provides a single magnetic piezoelectric acupuncture embedding wire and a preparation method thereof, so as to solve the technical problem that a single magnetic piezoelectric acupuncture embedding wire is difficult to prepare.

[0007] The technical solution adopted by the present invention is as follows:

[0008] A single magnetic piezoelectric acupuncture embedding thread, which is a thread body obtained by sequentially polarizing a dispersion of piezoelectric material and magnetic material with a high-voltage electric field, soaking in liquid, drawing and drying, wherein the liquid in the liquid soaking is water or a hydrogel material.

[0009] Preferably, the piezoelectric material is polyvinylidene fluoride.

[0010] Furthermore, the magnetic material is CoFe 2 O 4 .

[0011] Furthermore, the CoFe 2 O 4 The mass fraction is 2 to 4%.

[0012] Preferably, the hydrogel material is one or more of gellan gum, gelatin, chitosan, sodium alginate, collagen, hyaluronic acid, chondroitin sulfate, polyacrylamide, polyethylene glycol, polyacrylic acid, polyvinyl alcohol, polyhydroxyethyl methacrylate and derivatives thereof.

[0013] The method for preparing a single magnetic piezoelectric acupuncture embedding thread comprises the following steps:

[0014] (1) preparing a magnetic material suspension;

[0015] (2) dispersing the piezoelectric material in a solvent to form a dispersion;

[0016] (3) mixing the magnetic material suspension and the piezoelectric material dispersion, and stirring non-magnetically for 2 to 8 hours to obtain a precursor solution;

[0017] (4) placing the precursor solution in a high voltage electric field polarization device with a voltage range of 8 to 22 kV;

[0018] (5) Under a high voltage electric field, immersing the precursor solution polarized by the high voltage electric field in water or a hydrogel material for 10 minutes;

[0019] (6) using a circumferential collecting device selected from a cylindrical roller support, a cylindrical drum, a circular skeleton drum and a circular skeleton roller support, firstly pulling out a wire body and hanging it on the circumferential collecting device, and then using the circumferential collecting device to curl and collect a single magnetic piezoelectric acupuncture thread precursor;

[0020] (7) The collected single magnetic piezoelectric acupuncture embedding thread precursor is kept still for 10 to 16 hours, and then dried in a forced air drying oven at a temperature of 50 to 100° C. for 10 to 16 hours to obtain a single magnetic piezoelectric acupuncture embedding thread precursor.

[0021] Preferably, in step (6), the distance between the circular collecting device and the liquid immersion device is 15 cm.

[0022] In summary, compared with the prior art, the present invention has the following advantages and beneficial effects:

[0023] The present invention can extract a wire material that meets the requirements of acupuncture thread embedding by immersing the precursor liquid in a specific liquid after high-voltage electric field polarization treatment, thereby achieving the goal of preparing a single acupuncture thread embedding with both magnetic and piezoelectric properties. The prepared acupuncture thread embedding has excellent electrical signal stimulation and magnetic stimulation potential, providing an application basis for improving the efficacy of acupuncture point treatment. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] The present invention will now be described by way of example with reference to the accompanying drawings, in which:

[0025] Figure 1 Physical picture and optical microscope image of a single magnetic piezoelectric acupuncture thread prepared by wet process (gellan gum).

[0026] Figure 2 This is a graph showing the magnetic properties characterization results of a single magnetic piezoelectric acupuncture thread prepared by a wet process (gellan gum).

[0027] Figure 3 This is a graph showing the piezoelectric properties characterization results of a single magnetic piezoelectric acupuncture thread prepared by a wet process (gellan gum).

[0028] Figure 4 This is the EdU result of promoting cell proliferation activity by a single magnetic piezoelectric acupuncture thread prepared by wet process (gellan gum).

[0029] Figure 5 Actual photo and optical microscope image of a single magnetic piezoelectric acupuncture thread prepared by wet process (water).

[0030] Figure 6 This is a diagram showing the magnetic properties characterization results of a single magnetic piezoelectric acupuncture thread prepared by a wet process (water).

[0031] Figure 7 This is a graph showing the piezoelectric properties characterization results of a single magnetic piezoelectric acupuncture thread prepared by a wet process (water).

[0032] Figure 8 0, 1, 2, 3 and 4 wt.% CoFe were prepared for the wet process (water) 2 O 4 The voltage output curve test results of a single magnetic piezoelectric acupuncture thread.

[0033] Fig. 9 Preparation of 1, 2, 3 and 4 wt.% CoFe for wet process (water) 2 O 4 Magnetic hysteresis loop curve test results of a single magnetic piezoelectric acupuncture thread.

[0034] Fig.10 The design drawings of the wire bodies prepared by extrusion 3D printing technology combined with the wet process (gellan gum) and the actual collection of the physical pictures of the "wire bodies". DETAILED DESCRIPTION

[0035] The single magnetic piezoelectric acupuncture embedding thread provided by the present invention comprises the following steps:

[0036] (1) preparing a magnetic material suspension;

[0037] (2) dispersing the piezoelectric material in a solvent to form a dispersion;

[0038] (3) mixing the magnetic material suspension and the piezoelectric material dispersion, and stirring non-magnetically for 2 to 8 hours to obtain a precursor solution;

[0039] (4) placing the precursor solution in a high voltage electric field polarization device with a voltage range of 8 to 22 kV;

[0040] (5) Under a high voltage electric field, immersing the precursor solution polarized by the high voltage electric field in one or more liquids selected from the group consisting of water, gellan gum, gelatin, chitosan, sodium alginate, collagen, hyaluronic acid, chondroitin sulfate, polyacrylamide, polyethylene glycol, polyacrylic acid, polyvinyl alcohol, polyhydroxyethyl methacrylate and derivatives thereof for 10 minutes;

[0041] (6) using a circumferential collecting device selected from a cylindrical roller support, a cylindrical drum, a circular skeleton drum and a circular skeleton roller support, firstly pulling out a wire body and hanging it on the circumferential collecting device, and then using the circumferential collecting device to curl and collect a single magnetic piezoelectric acupuncture thread precursor;

[0042] (7) The collected single magnetic piezoelectric acupuncture embedding thread precursor is kept still for 10 to 16 hours, and then dried in a forced air drying oven at a temperature of 50 to 100° C. for 10 to 16 hours to obtain a single magnetic piezoelectric acupuncture embedding thread precursor.

[0043] In order to make the purpose, technical solutions and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the accompanying drawings and examples, wherein Example 1, Example 2 and Example 3 are specific implementation methods of the present invention, and Comparative Example 1, Comparative Example 2 and Comparative Example 3 are control groups.

[0044] Example 1

[0045] This embodiment provides a single magnetic piezoelectric acupuncture embedding thread, and the preparation process is as follows:

[0046] S1. Configure CoFe 2 O 4 suspension and 16wt.% polyvinylidene fluoride N,N-dimethylformamide solution (magnetic stirring for 12h);

[0047] S2. CoFe in S1 2 O 4 The suspension and the N,N-dimethylformamide solution of polyvinylidene fluoride were stirred non-magnetically for 4 h to prepare a mixed precursor solution;

[0048] S3. Setting a high voltage polarization electric field with an electric field strength of 15 kV to polarize the mixed precursor solution;

[0049] S4. A culture dish with a polytetrafluoroethylene stirring rod fixed on the top is set in a high-voltage polarization electric field, the culture dish is filled with gellan gum, and the mixed precursor solution after high-voltage electric field polarization is immersed in the gellan gum for 10 minutes;

[0050] S5. Add a cylindrical roller stand, the distance between the cylindrical roller stand and the culture dish filled with gellan gum is 15 cm, and the gellan gum needs to be heated to maintain 70°C. Start curling and collecting a single magnetic piezoelectric acupuncture thread precursor, and the relative air humidity during collection is 75%;

[0051] S6. The single magnetic piezoelectric acupuncture thread precursor collected by the cylindrical roller bracket is kept still for 12 hours, and then placed in a forced air drying oven at a temperature of 60° C. for drying for 12 hours to obtain a single magnetic piezoelectric acupuncture thread precursor.

[0052] like Figure 1 As shown in the figure, a single magnetic piezoelectric acupuncture thread prepared in this embodiment is physically photographed and imaged under an optical microscope. The thread is a single thread with a diameter of 0.17 mm ± 0.014 mm. Figure 2 As shown in the figure, it can be seen that the saturation magnetization intensity B of a single magnetic piezoelectric acupuncture thread prepared in this embodiment is S 4.26A·m 2 kg -1 , proving that it has magnetic properties.

[0053] like Figure 3 As shown, it is a piezoelectric performance diagram of a single magnetic piezoelectric acupuncture thread prepared in this embodiment, and the voltage output is 0.16mV, proving that it has obvious piezoelectric performance.

[0054] Figure 4 The results of the EdU test on the cell proliferation activity of a single magnetic piezoelectric acupuncture thread prepared in this example show that CoFe 2 O 4 The magnetic piezoelectric acupuncture thread embedded in composite with polyvinylidene fluoride can significantly enhance the proliferation activity of cells and has the biological function of acupuncture thread embedded.

[0055] Therefore, this embodiment successfully prepared a single magnetic piezoelectric acupuncture thread embedding having both piezoelectric properties and magnetic properties, and the magnetic piezoelectric acupuncture thread embedding has a relatively thin diameter, which meets the national standard requirements for acupuncture thread embedding.

[0056] Example 2

[0057] This embodiment provides a single magnetic piezoelectric acupuncture embedding thread, and the preparation process is as follows:

[0058] S1. Configure CoFe 2 O 4 suspension and 16wt.% polyvinylidene fluoride N,N-dimethylformamide solution (magnetic stirring for 12h);

[0059] S2. CoFe in S1 2 O 4The suspension and the N,N-dimethylformamide solution of polyvinylidene fluoride were stirred non-magnetically for 4 h to prepare a mixed precursor solution;

[0060] S3. Setting a high voltage polarization electric field with an electric field strength of 15 kV to polarize the mixed precursor solution;

[0061] S4. A culture dish with a polytetrafluoroethylene stirring rod fixed on the top is set in a high-voltage polarization electric field, the culture dish is filled with water, and the mixed precursor solution after high-voltage electric field polarization is immersed in water for 10 minutes;

[0062] S5. Add a cylindrical roller stand, the distance between the cylindrical roller stand and the culture dish filled with water is 15 cm, and start curling and collecting a single magnetic piezoelectric acupuncture thread precursor, and the relative air humidity during collection is 65% to 99%;

[0063] S6. The single magnetic piezoelectric acupuncture thread precursor collected by the cylindrical roller bracket is kept still for 12 hours, and then placed in a forced air drying oven at a temperature of 60° C. for drying for 12 hours to obtain a single magnetic piezoelectric acupuncture thread precursor.

[0064] like Figure 5 As shown, the actual picture and optical microscope image of a single magnetic piezoelectric acupuncture thread prepared in this embodiment are shown. The thread is a single thread with a diameter of 0.09 mm ± 0.006 mm.

[0065] like Figure 6 As shown in the figure, it can be seen that the saturation magnetization intensity B of a single magnetic piezoelectric acupuncture thread prepared in this embodiment is S 3.77A·m 2 kg -1 , proving that it has magnetic properties.

[0066] like Figure 7 As shown, the piezoelectric voltage output of the single magnetic piezoelectric acupuncture embedding thread prepared in this embodiment is 0.19mV, which proves that it has piezoelectric properties. Therefore, this embodiment successfully prepared a single magnetic piezoelectric acupuncture embedding thread, and compared with the acupuncture embedding thread soaked in gellan gum, the acupuncture embedding thread soaked in water has a thinner diameter and higher piezoelectric properties, but the magnetic properties are reduced.

[0067] Example 3

[0068] This example explores the CoFe 2 O 4 Effect of the composition ratio of CoFe and PVDF on the performance of acupuncture thread embedding, among which CoFe 2 O 4 CoFe 2 O 4, and the percentage of the total mass of polyvinylidene fluoride were selected as 0, 1, 2, 3, 4 and 5wt.% respectively.

[0069] Among them, it may be due to 5wt.% CoFe 2 O 4 The dosage was too high, and the high voltage polarization electric field failed to smoothly polarize the mixed precursor solution, and ultimately CoFe was not prepared. 2 O 4 A single magnetic piezoelectric acupuncture thread with a content of 5wt.% was used to prepare only CoFe 2 O 4 A single magnetic piezoelectric acupuncture embedding thread having a content of 0, 1, 2, 3 and 4 wt.%.

[0070] like Figure 8 As shown, this example is the preparation of CoFe 2 O 4 The voltage output curve test results of a single magnetic piezoelectric acupuncture thread with 0, 1, 2, 3 and 4 wt.% are shown in the figure. 2 O 4 When CoFe is 0 and 1wt.%, the voltage output of a single magnetic piezoelectric acupuncture thread is about 0.20mV, with no significant change. 2 O 4 When the CoFe content is 2wt.%, the voltage output is about 0.55mV, reaching the maximum. 2 O 4 When the CoFe2+ content is 3wt.% and 4wt.%, the voltage output is slightly reduced, but still larger than the values ​​of 0 and 1wt.%. Therefore, for the piezoelectric performance of a single magnetic piezoelectric acupuncture thread, CoFe2+ 2 O 4 The appropriate proportion is 2 to 4 wt.%. In addition, Figure 8 The data also show that the specific content of CoFe 2 O 4 The addition of can also significantly improve the piezoelectric properties of the material.

[0071] like Fig. 9 As shown, this example is the preparation of CoFe 2 O 4 The hysteresis loop curve test results of a single magnetic piezoelectric acupuncture thread with 1, 2, 3 and 4 wt.% are shown in the figure. 2 O 4 The magnetic curve of each single magnetic piezoelectric acupuncture thread was tested, and the magnetic properties of 4wt.% were the highest, reaching 0.04emu / g. 2 O 4There is no magnetic material in a single magnetic piezoelectric acupuncture thread, so there is no hysteresis loop curve test result. Therefore, for the magnetic properties of a single magnetic piezoelectric acupuncture thread, CoFe 2 O 4 Suitable proportions are 1, 2, 3 and 4 wt.%.

[0072] Combination Figure 8 and Fig. 9 As a result, it was concluded that the optimal mass fraction range of the ratio of magnetic material to piezoelectric material "x" suitable for preparing a single magnetic piezoelectric acupuncture thread is 2wt.%≤x≤4wt.%.

[0073] Comparative Example 1

[0074] On the basis of Example 2, the liquid immersion operation was cancelled, that is, the mixed precursor liquid after high-voltage electric field polarization was directly used to draw the wire (draw the wire) using a cylindrical roller bracket, but as a result, a complete wire body could not be drawn out.

[0075] Comparative Example 2

[0076] This comparative example uses common 3D printing technology to prepare the wire body, which specifically includes the following steps:

[0077] S1. Configure CoFe 2 O 4 suspension and 16wt.% polyvinylidene fluoride N,N-dimethylformamide solution (magnetic stirring for 12h);

[0078] S2. CoFe in S1 2 O 4 The suspension and the N,N-dimethylformamide solution of polyvinylidene fluoride were stirred non-magnetically for 4 h to prepare a mixed precursor solution;

[0079] S3. Prepare a single magnetic piezoelectric acupuncture thread using the mixed precursor solution by extrusion 3D printing. The extrusion 3D printing needle has a diameter of 0.51 mm, a printing speed of 4 mm / s, and an extrusion speed of 3.5 mm 3 / s, the printing model is set to concentric "circular" type.

[0080] As a result, the 3D printed "wire" in this comparative example collapsed, and ultimately failed to successfully prepare a single magnetic piezoelectric acupuncture thread.

[0081] Comparative Example 3

[0082] Based on Comparative Example 2, this comparative example performs a liquid immersion treatment on the mixed precursor liquid, and then uses 3D printing technology to prepare a wire body, which specifically includes the following steps:

[0083] S1. Configure CoFe 2 O4 suspension and 16wt.% polyvinylidene fluoride N,N-dimethylformamide solution (magnetic stirring for 12h);

[0084] S2. CoFe in S1 2 O 4 The suspension and the N,N-dimethylformamide solution of polyvinylidene fluoride were stirred non-magnetically for 4 h to prepare a mixed precursor solution;

[0085] S3. Prepare a single magnetic piezoelectric acupuncture thread using the mixed precursor solution by extrusion 3D printing. The extrusion 3D printing needle has a diameter of 0.51 mm, a printing speed of 4 mm / s, and an extrusion speed of 3.5 mm 3 / s, the printing model is set to a concentric "circle" shape, and a collection device filled with gellan gum is set under the needle of the extrusion 3D printing to collect the printed acupuncture thread in the gellan gum. The extrusion 3D printing base plate needs to heat the gellan gum and maintain the temperature at 70℃.

[0086] Fig.10 This is the extrusion-type 3D-printed acupuncture thread embedding collected in this comparative example. This comparative example preliminarily prepared a material with a "thread body" prototype, but the minimum diameter of the "thread body" can only achieve the specification of 1.06 mm ± 0.16 mm. Compared with the single magnetic piezoelectric acupuncture thread embedding with a diameter of 0.17 mm ± 0.014 mm prepared by the technical method of Example 1 and the single magnetic piezoelectric acupuncture thread embedding with a diameter of 0.09 mm ± 0.006 mm prepared by the technical method of Example 2, the diameter of the "thread body" in this comparative example is too large and does not meet the basic size requirement of the maximum diameter of 0.80 mm for acupuncture thread embedding.

[0087] It should be understood that the specific embodiments described in the above embodiments are only used to explain the present invention, and are not used to limit the present invention. That is, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. For example, the piezoelectric polymer substrate material of a single magnetic piezoelectric acupuncture thread is not limited to polyvinylidene fluoride, as long as the material itself can be configured into a polymer precursor liquid at room temperature, such as polylactic acid (PVA), polycaprolactone (PCL), polyvinyl alcohol (PVA), polyvinylidene fluoride (PVDF), polyethylene glycol (PEG); the magnetic material is not limited to CoFe 2 O 4 , including dysprosium iron (Dy-Fe), terbium iron (Tb-Fe), samarium iron (Sm-Fe), Fe 100-x Ga x (0<x<100), Fe 85 Ga 15-y Al y (0<y<15), Fe 80 Ga 20-z Alz (0<z<20), Fe 100-m Al m (0<m<100), Co n Fe 3-n O 4 (0<n<3) and other materials; the liquid used for soaking is not limited to water and gellan gum, as long as it is a hydrogel material, such as gelatin, collagen, chitosan, polyvinyl alcohol, polyacrylamide, methacrylated gelatin, methacrylated hyaluronic acid, hydroxyethyl methacrylate and other materials.

[0088] The above-mentioned embodiments only express the specific implementation methods of the present application, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the protection scope of the present application. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the technical solution concept of the present application, and these all belong to the protection scope of the present application.

Claims

1. A single magnetic piezoelectric acupuncture thread embedding device, characterized in that: The single magnetic piezoelectric acupuncture embedding thread is a thread body obtained by sequentially polarizing a dispersion of piezoelectric material and magnetic material with a high voltage electric field, soaking in liquid, drawing and drying the thread, wherein the liquid in the liquid soaking is water or a hydrogel material.

2. The single magnetic piezoelectric acupuncture embedding thread as claimed in claim 1, characterized in that: The piezoelectric material is polyvinylidene fluoride.

3. The single magnetic piezoelectric acupuncture embedding thread as claimed in claim 2, characterized in that: The magnetic material is CoFe2O4.

4. The single magnetic piezoelectric acupuncture embedding thread as claimed in claim 3, characterized in that: The mass fraction of the CoFe2O4 is 2-4%.

5. The single magnetic piezoelectric acupuncture embedding thread as claimed in claim 1, characterized in that: The hydrogel material is one or more of gellan gum, gelatin, chitosan, sodium alginate, collagen, hyaluronic acid, chondroitin sulfate, polyacrylamide, polyethylene glycol, polyacrylic acid, polyvinyl alcohol, polyhydroxyethyl methacrylate and derivatives thereof.

6. The method for preparing a single magnetic piezoelectric acupuncture embedding thread according to any one of claims 1 to 5, characterized in that: The steps include: (1) preparing a magnetic material suspension; (2) dispersing the piezoelectric material in a solvent to form a dispersion; (3) mixing the magnetic material suspension and the piezoelectric material dispersion, and stirring non-magnetically for 2 to 8 hours to obtain a precursor solution; (4) placing the precursor solution in a high voltage electric field polarization device with a voltage range of 8 to 22 kV; (5) Under a high voltage electric field, immersing the precursor solution polarized by the high voltage electric field in water or a hydrogel material for 10 minutes; (6) using a circumferential collecting device selected from a cylindrical roller support, a cylindrical drum, a circular skeleton drum and a circular skeleton roller support, firstly pulling out a wire body and hanging it on the circumferential collecting device, and then using the circumferential collecting device to curl and collect a single magnetic piezoelectric acupuncture thread precursor; (7) The collected single magnetic piezoelectric acupuncture embedding thread precursor is kept still for 10 to 16 hours, and then dried in a forced air drying oven at a temperature of 50 to 100° C. for 10 to 16 hours to obtain a single magnetic piezoelectric acupuncture embedding thread precursor.

7. The method for preparing a single magnetic piezoelectric acupuncture embedding thread according to claim 6, characterized in that: In step (6), the distance between the circular collecting device and the liquid immersion device is 15 cm.

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