Transcatheter intracardiac injection system

Abstract

The invention provides a transcatheter intramyocardial injection system, and relates to the technical field of myocardial injection. The transcatheter intracardiac injection system comprises a precise positioning module and an intelligent injection control module. Wherein the precise positioning module is used for carrying out high-precision three-dimensional imaging on myocardial tissues and precisely determining an injection position based on three-dimensional imaging; the intelligent injection control module is used for automatically adjusting an injection strategy based on the patient lesion degree information and patient injection process parameters collected in real time and controlling the injection process based on the injection strategy. The precise positioning module is arranged to be matched with the intelligent injection control module, the injection precision and safety of the transcatheter intracardiac injection system are improved, and then the safety and success rate of an operation are improved.

Description

Technical Field

[0001] The present invention relates to the technical field of myocardial injection, and in particular to a transcatheter myocardial injection system. Background Art

[0002] In the field of cardiovascular disease treatment, catheter intramyocardial injection technology, as an innovative interventional treatment method, has received widespread attention in recent years.

[0003] Traditional intramyocardial injection methods are mainly performed through surgical methods, which require open-chest surgery, which not only causes great trauma and pain to patients, but also requires a long recovery time after surgery; or less invasive interventional systems (such as catheter systems) are used to inject drugs into the heart. However, existing catheter systems have problems such as low injection accuracy, complex operation, and easy damage to myocardial tissue.

[0004] Therefore, based on this, the present application intends to propose a transcatheter intramyocardial injection system to at least solve one or more problems in the prior art. Summary of the invention

[0005] 1. Technical issues to be resolved

[0006] In view of the shortcomings of the prior art, the present invention provides a transcatheter intramyocardial injection system, which at least solves the problem of complex operation of the prior intramyocardial injection technology.

[0007] (II) Technical solution

[0008] To achieve the above objectives, the present invention is implemented through the following technical solutions:

[0009] A transcatheter intramyocardial injection system, the system comprising:

[0010] Precision positioning module, used for three-dimensional imaging of myocardial tissue and accurate determination of injection location;

[0011] Intelligent injection control module, which automatically adjusts the injection strategy based on the patient's lesion severity information and the patient's injection process parameters collected in real time, and performs injection based on the injection strategy;

[0012] The intelligent injection control module includes a drug release control unit, at least one sensor, and a controller; the sensor is electrically connected to the controller, and the controller is electrically connected to the drug release control unit.

[0013] Preferably, the sensor includes at least a drug concentration sensor and a physiological parameter monitoring sensor.

[0014] Preferably, the controller includes a single chip microcomputer.

[0015] In one embodiment, the precise positioning module includes an imaging unit and a navigation positioning unit, wherein the imaging unit is used to perform three-dimensional imaging of myocardial tissue, and the navigation positioning unit is used to guide the catheter to reach the target myocardial area by combining the three-dimensional imaging and navigation system.

[0016] Preferably, the imaging unit includes at least one or more of ultrasound, MRI, and CT.

[0017] In one embodiment, the drug release control unit includes a syringe and an adjustable catheter.

[0018] Preferably, the adjustable catheter comprises: a first microcatheter, a second microcatheter, and a limiting structure; wherein the first microcatheter and the second microcatheter are slidably connected, and an anti-drop limit is formed between the first microcatheter and the second microcatheter through the limiting structure.

[0019] More preferably, the limiting structure is a blocking ring.

[0020] Furthermore, the adjustable catheter also includes a sealing sleeve, which is arranged on the outer surface of the connection between the first micro-catheter, the second micro-catheter, and the limiting structure.

[0021] In another preferred embodiment, the adjustable catheter further comprises:

[0022] An angle adjustment component, the angle adjustment component includes: a traction wire, a fixing sleeve, a fixing frame, a winding reel, a baffle, and a control rod;

[0023] The fixing frame is arranged on the outer side wall of the first microcatheter through a fixing sleeve, the winding disk is rotatably arranged on the fixing frame, the side wall of the winding disk is rotatably matched with a baffle, and a control rod is arranged on the side wall of the winding disk; one end of the traction wire is connected to the side wall of the winding disk, and the other end passes through the through hole opened in the side walls of the first microcatheter and the second microcatheter and then extends to the vicinity of the front end needle of the second microcatheter.

[0024] Preferably, the traction wire is a steel wire.

[0025] In a further preferred embodiment, the adjustable catheter 1 further comprises:

[0026] A pipe diameter adjustment component, the pipe diameter adjustment component comprising: a telescopic sleeve, a corrugated rubber tube, an adjustable clamp, a fixing plate, and an adjusting bolt;

[0027] Among them, the outer side wall of the first microcatheter head end is sequentially covered with a telescopic sleeve, a corrugated rubber tube, an adjustable clamp, and a fixing plate from the inside to the outside; there are two fixing plates, which are correspondingly arranged on the side walls of the two ends of the corrugated rubber tube, and the middle parts of the two fixing plates are connected with adjusting bolts through threads.

[0028] In one embodiment, the drug release control unit further includes drugs and cell carriers.

[0029] In another embodiment, the system further includes: a remote operation and monitoring module, which is electrically connected to the precise positioning module and the intelligent injection control module, and is used for remote monitoring and remote operation of the injection process.

[0030] Preferably, the remote operation and monitoring module comprises an interaction unit for operating and controlling the entire injection process.

[0031] (III) Beneficial effects

[0032] The present invention provides a transcatheter intramyocardial injection system. Compared with the prior art, it has the following beneficial effects:

[0033] The present invention provides a transcatheter intramyocardial injection system, which realizes high-precision three-dimensional imaging of myocardial tissue and accurate determination of injection position by setting up a precise positioning module and combining three-dimensional imaging technology with a navigation system. At the same time, in conjunction with the sensors and controllers in the intelligent injection control module, and the drug release control unit, the drug release rate is adjusted according to the patient's physiological parameters such as the degree of lesions, heart beats, and drug concentration feedback, thereby improving the accuracy and safety of the injection, and thus improving the safety and success rate of the operation. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0035] Figure 1 This is a principle block diagram of a transcatheter myocardial injection system according to an embodiment of the present invention;

[0036] Figure 2 is a schematic diagram of the overall structure of an adjustable catheter in an embodiment of the present invention;

[0037] Figure 3 It is a connection schematic diagram of the limiting structure in an embodiment of the present invention;

[0038] Figure 4 This is a schematic diagram of the structure of an angle adjustment assembly in an embodiment of the present invention;

[0039] Figure 5 It is a structural schematic diagram of a pipe diameter adjustment assembly in an embodiment of the present invention;

[0040] In the figure: 1-adjustable catheter; 2-injection needle;

[0041] 11-first micro-catheter; 12-second micro-catheter; 13-limiting structure; 14-angle adjustment component; 15-tube diameter adjustment component; 16-sealing sleeve;

[0042] 141- traction wire drawing; 142- fixed sleeve; 143- fixed frame; 144- reel; 145- baffle; 146- control rod;

[0043] 151- telescopic sleeve; 152- corrugated rubber tube; 153- adjustable clamp; 154- fixing plate; 155- adjusting bolt. DETAILED DESCRIPTION

[0044] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention are clearly and completely described. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0045] The embodiment of the present application provides a transcatheter intramyocardial injection system, which at least solves the problem of complex operation of existing intramyocardial injection technology and achieves the purpose of intelligent and high-precision injection.

[0046] The technical solution in the embodiment of the present application is to solve the above technical problems, and the overall idea is as follows:

[0047] In order to solve the above problems existing in the existing myocardial injection technology, a transcatheter myocardial injection system is proposed in this application. First, the ultrasound, MRI and CT imaging technologies in the precise positioning module of the system are used for multimodal imaging guidance, and high-precision three-dimensional imaging of the myocardial tissue is performed to accurately determine the injection position. When the catheter is inserted into the patient's body, the catheter automatically adjusts the catheter position through the controller according to the real-time feedback of the heart beat detected by the sensor; then, during the injection, the drug release control unit in the intelligent injection control module adjusts the drug release rate according to the patient's lesion degree, heart beat and other physiological parameters and drug concentration feedback. When the length, angle and diameter of the catheter need to be adjusted according to different injection requirements, the corresponding functions are realized by the correspondingly set catheter sliding connection relationship and limit structure, angle adjustment component, diameter adjustment component, etc. In addition, the doctor can also remotely operate and monitor the injection process through the remote operation and monitoring module, which is convenient for timely adjustment of the treatment plan and response to emergencies.

[0048] In order to better understand the above technical solution, the above technical solution will be described in detail below in conjunction with the accompanying drawings and specific implementation methods.

[0049] Embodiment 1:

[0050] The following is combined with Figure 1-5 , and an explanation of the specific structure are provided to describe in detail the implementation process of the embodiment of the present invention.

[0051] See also Figure 1 , a transcatheter intramyocardial injection system, which includes a precise positioning module and an intelligent injection control module.

[0052] The precise positioning module is used to perform high-precision three-dimensional imaging of myocardial tissue and accurately determine the injection position based on the three-dimensional imaging; the intelligent injection control module automatically adjusts the injection strategy based on the patient's lesion severity information and the patient's injection process parameters collected in real time, and controls the injection process based on the injection strategy. Among them:

[0053] The precise positioning module uses a combination of three-dimensional imaging technology and a navigation system to perform high-precision three-dimensional imaging of myocardial tissue and accurately determine the injection position based on the three-dimensional imaging and the navigation system. Specifically, the precise positioning module includes an imaging unit and a navigation positioning unit. Specifically:

[0054] The imaging unit integrates at least one or more of ultrasound, MRI, and CT imaging technologies to conduct multimodal imaging guidance and high-precision three-dimensional imaging of myocardial tissue. During preoperative preparation, the patient undergoes a comprehensive imaging examination, using ultrasound, MRI, CT and other technologies to obtain detailed information about myocardial tissue, and constructs a high-precision three-dimensional image of myocardial tissue based on imaging data.

[0055] The navigation and positioning unit combines the three-dimensional image of myocardial tissue generated by the imaging unit using three-dimensional imaging technology with the navigation system, and uses the navigation system to guide the operator to operate the catheter to accurately reach the target myocardial area based on the position information provided by the three-dimensional image. During the entire process of catheter entry, the three-dimensional image and position information of the myocardial tissue are updated in real time to ensure the accuracy of navigation and positioning. The operating doctor can intuitively see the three-dimensional image of the myocardial tissue and the position of the catheter through the display screen, and operate according to the prompts of the navigation system to accurately reach the target injection position.

[0056] The intelligent injection control module automatically adjusts the injection speed, injection pressure and injection dose according to the characteristics of the myocardial tissue and the degree of the patient's lesions, and monitors the injection process parameters in real time through sensors. Specifically, the intelligent injection control module includes a drug release control unit, at least one sensor, and a controller. The sensor is electrically connected to the controller, and the controller is electrically connected to the drug release control unit.

[0057] Among them, the drug release unit includes a syringe and an adjustable catheter 1. The drug is directly delivered to the heart tissue through the syringe and the adjustable catheter 1 for drug injection and release. The sensor includes at least a drug concentration sensor, which is used to monitor the drug concentration at the injection site in real time. In addition, the sensor also includes a physiological parameter monitoring sensor for detecting patient physiological parameters such as heart beats. The physiological parameter monitoring sensor is generally arranged on the adjustable catheter 1 or arranged near the injection needle 2, and these sensors are connected to the controller. According to the feedback of physiological data such as heart beats detected by the sensor, on the one hand, the adjustable catheter 1 can have an adaptive positioning mechanism, accurately locate the injection position according to the heart beat signal, and at the same time, the patient's physiological data can be fed back to the controller, and instructions are generated to act on the drug release control unit. The drug release control unit then controls the syringe to cooperate with the adjustable catheter 1, and can flexibly adjust the drug release rate according to the physiological parameters of the patient's heart and the drug concentration feedback. The controller is used to control the drug release unit to adjust the drug release rate according to the data collected by the drug concentration sensor and other sensors.

[0058] When implementing intelligent injection, first set a basic injection strategy based on the patient's disease severity, that is, set a basic drug injection speed, injection pressure and injection dose. Then use sensors to monitor parameters such as injection pressure and flow rate during the injection process, as well as physiological parameters such as the patient's heart rate, in real time. The controller automatically adjusts the injection speed, pressure and dose based on the data fed back by the sensors and the preset algorithm. Next, use the controller to control the motor to rotate at a predetermined speed, and the output end of the motor is connected to the syringe to push the syringe for injection.

[0059] In this embodiment, the controller can use a single-chip microcomputer, such as an STM32 series single-chip microcomputer. During the intelligent injection process, for example, when the sensor detects that the pressure at the injection site is too high, the controller will automatically reduce the injection speed and control the motor to rotate at a slower speed. For another example, when a change in the patient's physiological parameters is detected, the dosage of the drug is adjusted according to the actual situation. The drug concentration sensor in the drug release control unit monitors the drug concentration at the injection site in real time. The controller controls the motor rotation to adjust the drug release rate at any time according to the data of the drug concentration sensor and the physiological parameters of the heart (such as heart rate, blood pressure), etc. When the drug concentration is too high, the controller will reduce the drug release rate.

[0060] In addition, in a preferred embodiment, the drug release unit also includes drugs and cell carriers, which can be loaded with a variety of therapeutic drugs and stem cells, and are surface-modified with targeting molecules. Both the drugs and cell carriers are biocompatible and can be safely degraded in vivo, solving the problems of low drug delivery efficiency and low cell survival rate in the prior art, and improving the therapeutic effect and the success rate of cell transplantation.

[0061] Furthermore, the syringe and the adjustable catheter 1 are both made of biocompatible materials to improve compatibility with human tissues, thereby solving the problem in the prior art that catheters and syringes are prone to induce immune and rejection reactions, and reducing the patient's pain and the risk of complications.

[0062] The intelligent injection control module realizes the regulation of drug release rate according to the physiological parameters of the heart and the feedback of drug concentration, which solves the problem of fixed drug release rate and inability to adapt to the needs of different patients in the prior art and improves the treatment effect.

[0063] See also Figure 2-5 In a preferred embodiment, the adjustable catheter 1 includes a first micro-catheter 11, a second micro-catheter 12, and a limiting structure 13. The first micro-catheter 11 and the second micro-catheter 12 are slidably connected, and the first micro-catheter 11 and the second micro-catheter 12 are provided with an anti-drop limit by the limiting structure 13. Figure 2-3 shown.

[0064] In a preferred embodiment, Figure 3 As shown, the above-mentioned limiting structure 13 is a blocking ring, the inner side wall of the above-mentioned first microcatheter 11 is slidably matched with the second microcatheter 12, and the outer side wall of one end of the second microcatheter 12 embedded in the first microcatheter 11 is fixedly connected with the blocking ring, and the first microcatheter 11 has a stop block or a contraction opening (the diameter of the contraction opening is smaller than the normal diameter of the first microcatheter 11) at the tube mouth of the end in cooperation with it, and the blocking ring and the stop block or the contraction opening cooperate with each other so that the second microcatheter 12 will not fall off when it slides, expands, contracts or shortens in the first microcatheter 11. Of course, in actual application, the limiting structure 13 is not limited to the matching form of the stop block or the contraction opening and the blocking ring, and other structures that can form a limit between the first microcatheter 11 and the second microcatheter 12 are also within the protection scope of this application.

[0065] Furthermore, in order to ensure the sealing and sanitary conditions when the pipelines are connected, it is more preferred that a sealing sleeve 16 is provided on the outer surface of the connection between the first micro-catheter 11, the second micro-catheter 12, and the limiting structure 13, as shown in FIG. Figure 2-3 Preferably, the outer walls of the first microcatheter 11, the second microcatheter 12 and the sealing sleeve 16 are all coated with a special coating, and the special coating is made of polyphenol-reinforced glycocalyx-like hydrogel.

[0066] During operation, the length of the catheter can be adjusted according to actual needs through the sliding cooperation between the first microcatheter 11 and the second microcatheter 12, and the second microcatheter 12 can be limited by the limiting structure 13 to prevent the second microcatheter 12 from falling off the first microcatheter 11. The joint between the second microcatheter 12 and the limiting structure 13 can be sealed by the sealing sleeve 16 to reduce liquid leakage. In addition, the outer walls of the first microcatheter 11, the second microcatheter 12 and the sealing sleeve 16 are coated with a polyphenol-reinforced glycocalyx-like hydrogel coating, which has good hydrophilicity and free radical scavenging ability, and can release specific complexes, which can effectively inhibit the adhesion of platelets and whole blood, have good anti-thrombotic ability, and promote endothelial cell adhesion and migration, protect myocardial cells and promote their adhesion.

[0067] In a preferred embodiment, in order to facilitate the adjustment of the injection angle of the adjustable catheter 1 during intramyocardial injection, a sliding angle adjustment component 14 is provided in the middle of the first microcatheter 11 and the second microcatheter 12. The angle adjustment component 14 includes a traction wire 141, a fixing sleeve 142, a fixing frame 143, a winding disk 144, a baffle 145, and a control rod 146. Figure 4 shown.

[0068] Through holes are provided in the side walls of the first microcatheter 11 and the second microcatheter 12, and a traction wire 141 is slidably fitted. In order to facilitate the winding of the traction wire 141 and thus facilitate the adjustment of the angle of the pipeline, a fixing sleeve 142 is fixedly connected to the outer wall of the first microcatheter 11, a fixing frame 143 is fixedly connected to the outer wall of the fixing sleeve 142, a winding disk 144 is rotatably fitted in the middle of the fixing frame 143, one end of the traction wire 141 is fixedly connected to the side wall of the winding disk 144, and the other end extends through the through hole to the front injection needle 2 of the second microcatheter 12. A baffle 145 is rotatably fitted to the side wall of the winding disk 144, and a control rod 146 is fixedly connected to the side wall of the winding disk 144.

[0069] During operation, the reel 144 can be rotated by the control rod 146 to reel in the traction wire 141, thereby pulling the end of the first microcatheter 11 to achieve angle adjustment. The baffle 145 can prevent the reel 144 from deviating and falling off when reeling in the traction wire 141, further enhancing the angle adjustment effect of the adjustable catheter 1. Preferably, the traction wire 141 is preferably a steel wire.

[0070] In this embodiment, the angle of the end of the first microcatheter 11 can be adjusted by the angle adjustment component 14, so as to facilitate intramyocardial injection at the optimal angle.

[0071] In a more preferred embodiment, in order to control the amount of the injection during the intramyocardial injection, the amount of the injection is controlled by controlling the size of the injection tube. In order to achieve the purpose of controlling the size of the tube, a tube diameter adjustment component 15 is provided on the outer side wall of the tip of the first microcatheter 11. Specifically, Figure 5 As shown, the pipe diameter adjustment assembly 15 includes a telescopic sleeve 151 , a corrugated rubber tube 152 , an adjustable clamp 153 , a fixing plate 154 , and an adjusting bolt 155 .

[0072] A telescopic sleeve 151 is fixedly connected to the outer wall of the head end of the first micro-catheter 11, a corrugated rubber tube 152 is installed on the outer wall of the telescopic sleeve 151, an adjustable clamp 153 is fixedly connected to the outer wall of the corrugated rubber tube 152, and a fixing plate 154 is fixedly connected to the outer wall of the adjustable clamp 153. There are two fixing plates 154, which are correspondingly arranged on the side walls of the two ends of the corrugated rubber tube 152, and the middle parts of the two fixing plates 154 are connected by threads with adjusting bolts 155.

[0073] During operation, the docking diameter of the end of the first microcatheter 11 can be expanded or reduced by flipping the corrugated rubber tube 152, and the diameter of the end of the corrugated rubber tube 152 can be adjusted by the adjustable clamp 153. The adjusted adjustable clamp 153 is fixed by the fixing plate 154 and the adjusting bolt 155, thereby further enhancing the diameter adjustment effect of the adjustable catheter 1.

[0074] In addition, the injection needle 2 has functions such as retractable, rotatable, and bendable, and a micro sensor is provided on the surface of the needle to monitor the myocardial tissue reaction in real time, which solves the problem that the injection needle 2 in the prior art has a single function and cannot adapt to complex injection environments, thereby reducing surgical risks.

[0075] The adjustable catheter 1 in this embodiment can automatically adjust the position of the catheter itself according to the real-time feedback of the heart's beating. Among them, the adjustable catheter 1 can select the appropriate angle, tube length, and tube diameter according to actual needs through the limiting structure 13 between the pipes, the angle adjustment component 14, and the tube diameter adjustment component 15 to achieve a better and more accurate filling effect. In addition, the special coating on the surface of the catheter can reduce friction with the myocardial tissue and avoid damage to the myocardial tissue.

[0076] In addition, in a further embodiment, the transcatheter intramyocardial injection system in any of the above embodiments further includes a remote operation and monitoring module. Figure 1The remote operation and monitoring module is electrically connected to the above-mentioned precise positioning module and the intelligent injection control module to obtain the three-dimensional image of the patient's myocardial tissue and the data collected by the sensor and visualize it. At the same time, the treatment suggestions and operation instructions of the remote medical staff can be transmitted. The remote operation and monitoring module can realize the transmission of real-time images and parameters through high-speed data transmission, so that the doctor can operate and monitor the injection process remotely. Among them, the remote operation and monitoring module includes a user-friendly interactive unit to facilitate the doctor to operate and control the entire injection process.

[0077] By setting up a remote operation and monitoring module, doctors can remotely operate and monitor the injection process, making it easier to adjust treatment plans and respond to emergencies. This solves the problem in the prior art that doctors cannot grasp the injection situation in real time and cannot adjust treatment plans in a timely manner, thus improving treatment efficiency and safety.

[0078] The use method and implementation process of the transcatheter intramyocardial injection system proposed in the above embodiment of the present application are as follows:

[0079] First, preoperative preparation is carried out and the patient undergoes a comprehensive imaging examination, including ultrasound, MRI and CT. These imaging technologies are used to obtain detailed information about the myocardial tissue. The imaging data is input into the relevant system to construct a high-precision three-dimensional image of the myocardial tissue.

[0080] Then, precise positioning is performed and the precise positioning module is started. This module combines three-dimensional imaging technology with the navigation system. The navigation system guides the catheter to accurately reach the target myocardial area based on the position information provided by the three-dimensional image. During the entire process, the image and position information are updated in real time to ensure the accuracy of positioning. The doctor can intuitively see the three-dimensional image of the myocardial tissue and the position of the catheter through the display screen and operate according to the prompts of the navigation system.

[0081] Next, an adjustable catheter with an adaptive positioning mechanism is inserted into the body. The sensor on the catheter detects the heartbeat and transmits the detected heartbeat signal to the controller. The controller adjusts the position of the catheter in real time according to the signal to keep it in the correct injection position. At the same time, the length, angle and diameter of the catheter can be adjusted according to different injection requirements;

[0082] Next, prepare for drug injection and select appropriate drugs and cell carriers. The carriers can be loaded with a variety of therapeutic drugs and stem cells, and the surface is modified with targeting molecules. They are biocompatible and can be safely degraded in the body. The drugs and cell carriers are loaded into the syringe, which is made of biocompatible materials to improve compatibility with human tissues.

[0083] Finally, intelligent injection control is performed and the intelligent injection control module is started. The module includes a drug release control unit, physiological parameter monitoring, and a controller. The physiological parameter monitoring sensor monitors the pressure, flow and other parameters of the injection process and the heart beat in real time. The controller automatically adjusts the injection speed, pressure and dosage according to the data fed back by the sensor and the preset algorithm. When the sensor detects that the pressure at the injection site is too high, the controller will automatically reduce the injection speed; according to the degree of the lesion, the drug dosage is adjusted. The drug concentration sensor in the drug release control unit monitors the drug concentration at the injection site in real time. The controller adjusts the drug release rate at any time according to the data of the drug concentration sensor and the physiological parameters of the heart (such as heart rate, blood pressure), etc. When the drug concentration is too high, the feedback control system will reduce the drug release rate.

[0084] During the entire process described above, medical staff use remote operation and monitoring to remotely operate and monitor the injection process through a user-friendly interactive interface. The on-site equipment transmits real-time images and parameters to the remote terminal through high-speed data. Doctors can adjust the position of the catheter and control the injection speed of the drug on the remote terminal.

[0085] In summary, compared with the prior art, the present invention has the following beneficial effects:

[0086] 1. The present invention provides a transcatheter intramyocardial injection system, which realizes high-precision three-dimensional imaging of myocardial tissue and accurate determination of injection position by adopting a precise positioning module and combining three-dimensional imaging technology with a navigation system. At the same time, the sensor, controller and drug release control unit in the intelligent injection control module adjust the drug release rate according to the patient's lesion degree, heart beat and other physiological parameters and drug concentration feedback, and realizes automatic adjustment of injection speed, pressure and dosage according to myocardial tissue characteristics and lesion degree, and monitors the injection process parameters in real time through sensors, thereby improving the flexibility and controllability of injection, improving the accuracy and safety of injection, and thus improving the safety and success rate of surgery.

[0087] 2. The present invention proposes a transcatheter intramyocardial injection system, in which the adjustable catheter in the drug release control unit can adjust the length, angle and diameter of the catheter according to different injection requirements, and can further accurately find the injection position, thereby further improving the accuracy and safety of the injection, and improving the safety and success rate of the operation.

[0088] 3. The present invention proposes a transcatheter intramyocardial injection system, which realizes the transmission of real-time images and parameters by means of high-speed data transmission through a remote operation and monitoring module, so that doctors can remotely operate and monitor the injection process, thereby solving the problem in the prior art that doctors cannot grasp the injection situation in real time and cannot adjust the treatment plan in time, thereby improving the efficiency and safety of treatment.

[0089] 4. The present invention proposes a transcatheter intramyocardial injection system, which realizes functions such as retractability, rotatability, and bendability through the provision of a multifunctional injection needle, and monitors the myocardial tissue reaction in real time, thereby solving the problem in the prior art that the injection needle has a single function and cannot adapt to complex injection environments, and reducing surgical risks.

[0090] 5. The present invention proposes a transcatheter intramyocardial injection system, which improves compatibility with human tissue by arranging the catheter and the syringe to be made of biocompatible materials, solves the problem that the catheter and the syringe in the prior art are prone to induce immune response and rejection reaction, and reduces the patient's pain and the risk of complications.

[0091] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, the elements defined by the sentence "comprise a ..." do not exclude the presence of other identical elements in the process, method, article or device including the elements.

[0092] The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit the same. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that the technical solutions described in the aforementioned embodiments may still be modified, or some of the technical features may be replaced by equivalents. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A transcatheter intramyocardial injection system, characterized in that: The system comprises: Precision positioning module, used for three-dimensional imaging of myocardial tissue and accurate determination of injection location; Intelligent injection control module, which automatically adjusts the injection strategy based on the patient's lesion severity information and the patient's injection process parameters collected in real time, and performs injection based on the injection strategy; The intelligent injection control module includes a drug release control unit, at least one sensor, and a controller; the sensor is electrically connected to the controller, and the controller is electrically connected to the drug release control unit.

2. The system according to claim 1, characterized in that The precise positioning module includes an imaging unit and a navigation positioning unit. The imaging unit is used to perform three-dimensional imaging of myocardial tissue, and the navigation positioning unit is used to guide the catheter to reach the target myocardial area by combining the three-dimensional imaging and navigation system.

3. The system according to claim 2, characterized in that The imaging unit includes at least one or more of ultrasound, MRI, and CT.

4. The system according to claim 1, characterized in that The drug release control unit comprises a syringe and an adjustable catheter (1).

5. The system according to claim 4, characterized in that The adjustable catheter (1) comprises: a first micro-catheter (11), a second micro-catheter (12), and a limiting structure (13); wherein the first micro-catheter (11) and the second micro-catheter (12) are slidably connected, and an anti-drop limit is formed between the first micro-catheter (11) and the second micro-catheter (12) via the limiting structure (13).

6. The system according to claim 5, characterized in that The adjustable catheter (1) further comprises: An angle adjustment component (14), the angle adjustment component (14) comprising: a traction wire (141), a fixing sleeve (142), a fixing frame (143), a winding disk (144), a baffle (145), and a control rod (146); The fixing frame (143) is arranged on the outer wall of the first microcatheter (11) through a fixing sleeve (142); the winding disk (144) is rotatably arranged on the fixing frame (143); the side wall of the winding disk (144) is rotatably matched with a baffle (145), and a control rod (146) is arranged on the side wall of the winding disk (144); one end of the traction wire (141) is connected to the side wall of the winding disk (144), and the other end passes through the through holes opened in the side walls of the first microcatheter (11) and the second microcatheter (12) and then extends to the vicinity of the front end needle of the second microcatheter (12).

7. The system according to claim 6, characterized in that The adjustable catheter (1) further comprises: A pipe diameter adjustment component (15), the pipe diameter adjustment component (15) comprising: a telescopic sleeve (151), a corrugated rubber tube (152), an adjustable clamp (153), a fixing plate (154), and an adjustment bolt (155); The outer side wall of the head end of the first micro-catheter (11) is provided with a telescopic sleeve (151), a corrugated rubber tube (152), an adjustable clamp (153), and a fixing plate (154) in sequence from the inside to the outside; there are two fixing plates (154), which are correspondingly arranged on the side walls of the two ends of the corrugated rubber tube (152), and the middle parts of the two fixing plates (154) are connected with adjusting bolts (155) through threads.

8. The system according to claim 4, characterized in that The drug release control unit also includes drugs and cell carriers.

9. The system according to claim 1, characterized in that The system further comprises: a remote operation and monitoring module, which is electrically connected to the precise positioning module and the intelligent injection control module and is used for remote monitoring and remote operation of the injection process.

10. The system according to claim 9, characterized in that The remote operation and monitoring module includes an interaction unit for operating and controlling the entire injection process.

Images