A method for degrading paracetamol in fresh urine using periodate

Abstract

The present invention discloses a method for degrading paracetamol in fresh urine using periodate, namely, a method for degrading paracetamol ACE in fresh urine FU using periodate PI. The method comprises the following steps: adding periodate PI to fresh urine FU contaminated with paracetamol ACE to be treated, and uniformly mixing the mixture to achieve rapid and efficient degradation of ACE. The PI / FU system established by the present invention can synergistically promote the generation of singlet oxygen and hydroxyl free radicals, thereby achieving the purpose of rapid and efficient degradation of ACE. The present invention does not require additional energy supply or the addition of any exogenous activator, thereby greatly reducing costs, and has the advantages of highly efficient ACE degradation, environmental friendliness, and the like. The method has broad application prospects in ensuring water ecological safety and safe resource utilization of urine.

Description

Technical Field

[0001] The invention relates to the technical field of paracetamol degradation, and in particular to a method for degrading paracetamol in fresh urine using periodate. Background Art

[0002] Human urine is part of urban wastewater. Although its volume is less than 1% of the total volume, it is one of the main sources of pharmaceutical pollutants in wastewater. Paracetamol (ACE), as one of the most commonly used analgesics, has an annual global consumption of more than 140,000 tons. After patients take ACE, only 5-15% can be absorbed by the body, and 58% to 68% is excreted in the urine. However, the technology of most sewage treatment plants mainly targets substances such as nitrogen and phosphorus, and it is difficult to remove ACE efficiently. As a result, ACE is widely detected in the environment and may cause great harm to aquatic organisms, such as damaging the liver of freshwater fish and affecting the biological nervous system. Therefore, there is an urgent need to develop a treatment method for ACE-contaminated urine.

[0003] Advanced oxidation processes (AOPs) based on strong oxidative free radicals (such as hydroxyl radicals (·OH)) are often used to remove refractory organic pollutants in water. However, many AOPs are significantly limited in complex media such as urine. This is because urine contains high concentrations of HCO3 - NH4 + 、Cl - Plasma, these substances will quench OH or convert it into less active species, inhibiting the degradation of pollutants. At the same time, the urea in fresh urine FU will be hydrolyzed into NH3 and NH4 under the action of microorganisms. + and HCO3 - , forming alkaline hydrolyzed urine (HU), but this process will lose some nitrogen. Given that the organic components in FU are more complex, previous studies have mostly focused on treating pollutants in HU. For example, Zhang et al. used ultraviolet light to activate peroxydisulfate (PDS) to degrade sulfonamide antibiotics in HU, and Kung et al. used sunlight to drive PDS to remove caffeine and cefotaxime from HU. For ACE in HU, Nie Minghua et al. invented a treatment method using peroxymonosulfate (PMS) (authorization announcement number: CN113087122B) and achieved good results. However, most of the above methods require the addition of multiple reagents or energy (such as oxidants, activators and light) and are only applicable to HU, limiting their large-scale application.

[0004] In recent years, research on the degradation of pollutants based on PI has gradually increased. PI is a strong oxidant with a reduction potential of +1.6V. Compared with other common oxidants (such as H2O2, O3, etc.), PI has stronger chemical stability and its solid state enables long-distance transportation and long-term storage. Most previous studies have used various activation methods to activate PI to form active species (RS) to remove pollutants. The activation methods are divided into three types: (1) homogeneous activation (Mn 2+ 、Fe 2+ , H2O2, etc.); (2) heterogeneous activation (iron-based materials, TiO2-based materials, carbon materials, zinc-based materials and other metal oxides); (3) direct activation (freezing, light, heating, alkali). For example, Li et al. used Cu2O to activate PI to remove antibiotics in water, Zhang Yue et al. used water hyacinth biochar combined with PI to remove sulfadiazine (SD) in water, and Ye et al. used sunlight combined with PI to treat Gram-positive bacteria. For HU, Cai Tianming et al. constructed a biochar combined with PI system and found that electrons can be transferred from biochar to PI and form a high-potential metastable complex (biochar-PI*), thereby effectively removing SD. However, the above methods usually require external energy or chemical consumption, are costly, have high energy consumption, and may also produce heavy metal pollution and increase the risk of secondary pollution. In order to avoid the above shortcomings, it is particularly important to develop PI treatment technology without external activation means. However, the use of PI alone to degrade pollutants such as ACE has not been reported. Summary of the Invention

[0005] The present invention aims to overcome the shortcomings of the prior art and provides a method for degrading paracetamol in fresh urine using periodate, namely, a method for degrading paracetamol ACE in fresh urine FU using periodate PI. The method comprises the following steps: adding periodate PI to fresh urine FU contaminated with paracetamol ACE to be treated, and uniformly mixing to achieve rapid and efficient degradation of ACE. The PI / FU system established in the present invention can synergistically promote the generation of singlet oxygen and hydroxyl radicals, thereby achieving the purpose of rapid and efficient degradation of ACE. The present invention does not require additional energy supply or the addition of any exogenous activator, thereby greatly reducing costs, and has the advantages of highly efficient ACE degradation and environmental friendliness. The method has broad application prospects in ensuring water ecological safety and safe resource utilization of urine.

[0006] In order to achieve the above technical effects, the following technical solutions are adopted:

[0007] A method for degrading paracetamol in fresh urine using periodate is provided, which comprises: using periodate (PI) as an oxidant to directly degrade the drug paracetamol (ACE) in fresh urine (FU) at room temperature; the method specifically comprises the following steps:

[0008] Step S1: collecting fresh urine FU, wherein the fresh urine FU contains the drug paracetamol ACE;

[0009] Step S2: adding periodate PI to the fresh urine FU containing paracetamol ACE in step S1, stirring and mixing evenly, and obtaining urine in which paracetamol ACE is degraded after the reaction is completed.

[0010] Furthermore, the main components of the fresh urine FU include: urea, NaCl, Na2SO4, KCl, MgCl2·6H2O, NaH2PO4·2H2O, CaCl2, trisodium citrate dihydrate and water.

[0011] Furthermore, the concentration of the drug paracetamol ACE in fresh urine FU is 3-9 mmol / L.

[0012] Furthermore, the storage conditions of the fresh urine FU are: storing the urine FU at a temperature below 4° C. in the dark; and the time from the collection of the fresh urine FU to its use does not exceed 24 hours.

[0013] Furthermore, the pH value of the fresh urine FU is 6-9.

[0014] Furthermore, the periodate PI includes sodium periodate.

[0015] Furthermore, the concentration of the periodate PI in fresh urine FU is 0.5-4 mmol / L.

[0016] Furthermore, the stirring speed is 100-300 rpm.

[0017] Furthermore, the reaction time is 30-90 min.

[0018] Furthermore, the reaction temperature is 15-40°C.

[0019] The beneficial effects of the present invention are:

[0020] 1. The purpose of the present invention is to introduce periodate PI into fresh urine FU to form a PI / FU system to achieve the degradation of organic pollutants in fresh urine FU; the operation is simple, the reaction conditions are mild, the energy consumption is low, no additional energy supply is required, no exogenous activator is required, and the entry of toxic metal ions into the ecosystem to cause secondary pollution can be avoided. It has the characteristics of economy and environmental protection, strong adaptability and broad application prospects.

[0021] 2. The degradation efficiency of paracetamol ACE in fresh urine FU of the present invention is high. After treating fresh urine FU contaminated with paracetamol ACE for 50 minutes, the degradation rate of ACE can reach 100.00%.

[0022] 3. The periodate PI used is inexpensive, safe, stable, and easy to store and transport. Its use can also avoid the problem of secondary pollution of the treated water. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. The drawings described below are merely embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the provided drawings without paying any creative work.

[0024] Figure 1 The degradation curves of ACE by different systems of the present invention are shown;

[0025] Figure 2 This is a graph showing the degradation of ACE under different PI dosage conditions of the present invention;

[0026] Figure 3 This is a graph showing the degradation of ACE under different ACE concentration conditions of the present invention;

[0027] Figure 4 This is a graph showing the degradation of ACE under different liquid temperature conditions of the present invention;

[0028] Figure 5 This is a degradation curve diagram of ACE under different pH conditions of the present invention;

[0029] Figure 6 The degradation curves of ACE under different PI addition modes of the present invention are shown;

[0030] Figure 7 This is a graph showing the degradation of ACE under the conditions of different anions present in the present invention;

[0031] Figure 8 The degradation curve of ACE in the presence of different cations of the present invention;

[0032] Figure 9 For RS in the present invention (ascorbic acid AA for all RS, histidine L-His for 1 O2) Contribution of ACE in the degradation of urinary FU;

[0033] Figure 10 RS in the present invention (phenol PhOH for IO3 and IO4, nitro blue tetrazolium NBT for O2 ·- ) Contribution of ACE in the degradation of urinary FU;

[0034] Figure 11This is the contribution diagram of RS (tert-butyl alcohol TBA to ·OH) in the degradation of ACE in urine FU in the present invention;

[0035] Figure 12 This is the electron paramagnetic resonance spectrum of the PI / FU system of the present invention. DETAILED DESCRIPTION

[0036] In order to make the purpose, technical solutions and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.

[0037] It should be noted that the following detailed descriptions are exemplary and intended to provide further explanation of the present invention. Unless otherwise specified, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the art to which the present invention belongs.

[0038] It should be noted that the terms used herein are only for describing specific embodiments and are not intended to limit the exemplary embodiments according to the present invention. As used herein, unless the context clearly indicates otherwise, the singular form is intended to include the plural form. In addition, it should be understood that when the terms "comprise" and / or "include" are used in this specification, they indicate the presence of features, steps, operations and / or combinations thereof.

[0039] In the following embodiments:

[0040] 1. Collection and acquisition of real fresh urine FU:

[0041] The main components of fresh urine FU include: urea, NaCl, Na2SO4, KCl, MgCl2·6H2O, NaH2PO4·2H2O, CaCl2, trisodium citrate dihydrate and water.

[0042] The storage conditions of fresh urine FU are as follows: storing urine FU at a temperature below 4°C in the dark; the time from collection to use of the fresh urine FU does not exceed 24 hours; and the pH value of the fresh urine FU is about 6.

[0043] 2. Obtaining the real hydrolyzed urine HU:

[0044] Fresh urine typically begins to undergo significant urea hydrolysis within 4-6 hours at room temperature (approximately 20-25°C), and after 24 hours, true fully hydrolyzed urine (HU) with a pH of approximately 9 is obtained. Alternatively, simulated hydrolyzed urine (HU) can be obtained through laboratory preparation.

[0045] 3. Prepare simulated fresh urine FU and simulated hydrolyzed urine HU

[0046] The composition and pH values ​​of the simulated fresh urine (FU) and simulated hydrolyzed urine (HU) used in the present invention are shown in Table 1. The corresponding amounts of the substances listed in the table were dissolved in water. After the solids were completely dissolved, the volume was adjusted to a 1000 mL volumetric flask. The urine was filtered using a microporous filter with a pore size of 0.45 μm to remove suspended impurities and stored in a refrigerator at 4°C.

[0047] Table 1 Composition of urine

[0048]

[0049] 4. Prepare phosphate buffer (PB) solution (pH 6), called PB6

[0050] Adjust 250 mL of 0.2 mol / L NaH2PO4 solution with 0.2 mol / L NaOH solution to obtain a phosphate buffer solution with a pH of 6, and adjust the volume to 1 L.

[0051] 5. Prepare phosphate buffer (PB) solution (pH 9), called PB9

[0052] Adjust 250 mL of 0.2 mol / L NaH2PO4 solution with 0.2 mol / L NaOH solution to obtain a phosphate buffer solution with a pH of 9, and adjust the volume to 1 L.

[0053] Example 1:

[0054] The present embodiment utilizes periodate PI to degrade and prepare the method for simulating the drug paracetamol ACE in fresh urine FU, which is achieved by the following steps:

[0055] (PI / Simulated FU): At room temperature (25±1°C), prepare a simulated fresh urine FU solution with an initial acetaminophen ACE concentration (C0) of 5 μmol / L and a pH of 6. A total volume of 100 mL was maintained, and a PI dosage of 2 mmol / L was used. After thorough stirring, the reaction was terminated with sodium thiosulfate. The acetaminophen ACE concentration (C) was measured at different reaction times. The degradation of the acetaminophen ACE over 70 minutes was determined, and the degradation rate was calculated.

[0056] Example 2:

[0057] The method of using periodate PI to degrade the drug paracetamol ACE in real fresh urine FU in this embodiment is achieved by the following steps:

[0058] (PI / real FU): At room temperature (25±1°C), the initial acetaminophen ACE concentration (C0) in real fresh urine FU was 5 μmol / L, the pH of real fresh urine FU was 6.0, and the total volume of the system was 100 mL. A PI dosage of 2 mmol / L was used. After thorough stirring, the reaction was terminated with sodium thiosulfate. The acetaminophen ACE concentration (C) in the system was measured at different reaction times to determine the degradation of the acetaminophen ACE over 70 minutes.

[0059] Example 3:

[0060] The method of using periodate PI to degrade the drug paracetamol ACE in PB6 in this embodiment is achieved by the following steps:

[0061] (PI / PB6): At room temperature (25±1°C), the initial acetaminophen ACE concentration (C0) in PB6 was 5 μmol / L. In a total volume of 100 mL, a PI dosage of 2 mmol / L was used. After thorough stirring, the reaction was terminated with sodium thiosulfate. The acetaminophen ACE concentration (C) in the system was measured at different reaction times to determine the degradation profile of the acetaminophen ACE over 70 minutes.

[0062] Example 4:

[0063] The method of using periodate PI to degrade the drug paracetamol ACE in PB9 in this embodiment is achieved by the following steps:

[0064] (PI / PB9): At room temperature (25±1°C), the initial paracetamol ACE concentration (C0) in PB9 was 5 μmol / L. A total volume of 100 mL was maintained, and a PI dosage of 2 mmol / L was used. After thorough stirring, the reaction was terminated with sodium thiosulfate. The paracetamol ACE concentration (C) in the system was measured at different reaction times to determine the degradation profile of the paracetamol ACE over 70 minutes.

[0065] Example 5:

[0066] This embodiment utilizes periodate PI to degrade and prepare a method for simulating the hydrolysis of paracetamol ACE in urine HU, which is achieved by the following steps:

[0067] (PI / simulated HU): At room temperature (25±1°C), prepare a simulated hydrolyzed urine solution (HU) with an initial acetaminophen ACE concentration (C0) of 5 μmol / L and a pH of 9. A total volume of 100 mL was maintained, and a periodate PI dosage of 2 mmol / L was used. After thorough stirring, the reaction was terminated with sodium thiosulfate. The acetaminophen ACE concentration (C) in the system was measured at different reaction times. The degradation of the acetaminophen ACE over 70 minutes was determined, and the degradation rate was calculated.

[0068] Example 6:

[0069] The method of utilizing periodate PI to degrade and hydrolyze the drug paracetamol ACE in urine HU is achieved by the following steps:

[0070] (PI / True HU): At room temperature (25±1°C), the initial acetaminophen ACE concentration (C0) in the true hydrolyzed urine HU was 5 μmol / L, the system pH was 9.0, and the total volume of the system was 100 mL. The PI dosage was 2 mmol / L. After thorough stirring, the reaction was terminated with sodium thiosulfate. The acetaminophen ACE concentration (C) in the system was measured at different reaction times to determine the degradation of the acetaminophen ACE over 70 minutes.

[0071] Comparative Example 1:

[0072] (PI / Water): At room temperature (25±1°C), the initial acetaminophen ACE concentration (C0) in pure water was 5 μmol / L. The system pH was adjusted to 6, and the total volume of the system was maintained at 100 mL. A PI dosage of 2 μmol / L was used. After thorough stirring, the reaction was terminated with sodium thiosulfate. The acetaminophen ACE concentration (C) in the system was measured at different reaction times to determine the degradation of acetaminophen ACE over 70 minutes.

[0073] Comparative Example 2:

[0074] (H2O2 / Real FU): At room temperature (25±1°C), the initial acetaminophen ACE concentration (C0) in real fresh urine FU was 5 μmol / L, the system pH was 6, and the total volume of the system was 100 mL. A 2 μmol / L amount of H2O2 was used. After thorough stirring, the reaction was terminated with sodium thiosulfate. The acetaminophen ACE concentration (C) in the system was measured at different reaction times to determine the degradation of acetaminophen ACE over 70 minutes.

[0075] Comparative Example 3:

[0076] (PMS / real FU): At room temperature (25±1°C), the initial acetaminophen ACE concentration (C0) in real fresh urine FU was 5 μmol / L, the system pH was 6, and a total volume of 100 mL was maintained. A PMS dosage of 2 μmol / L was used. After thorough stirring, the reaction was terminated with sodium thiosulfate. The acetaminophen ACE concentration (C) in the system was measured at different reaction times to determine the degradation of acetaminophen ACE over 70 minutes.

[0077] Comparative Example 4:

[0078] (PB6): At room temperature (25±1°C), the initial acetaminophen ACE concentration (C0) in PB6 was 5 μmol / L. The reaction was stirred thoroughly, maintaining a total volume of 100 mL, and terminated with sodium thiosulfate. The acetaminophen ACE concentration (C) in the system was measured at different reaction times to determine the degradation of acetaminophen ACE over 70 minutes.

[0079] Comparative Example 5:

[0080] (PB9): At room temperature (25±1°C), the initial acetaminophen ACE concentration (C0) in PB9 was 5 μmol / L. The reaction was stirred thoroughly, maintaining a total volume of 100 mL, and terminated with sodium thiosulfate. The acetaminophen ACE concentration (C) in the system was measured at different reaction times to determine the degradation of acetaminophen ACE over 70 minutes.

[0081] In addition, at room temperature (25±1°C), the initial paracetamol ACE concentration C0 in real fresh urine FU was 5 μmol / L, the system pH was 6, and after thorough stirring and stabilization, the reaction was terminated by the addition of an equivalent amount of sodium thiosulfate as described in Example 2. The paracetamol ACE concentration C in the system was measured at different times to determine the degradation of paracetamol ACE over 70 minutes. The results showed that the degradation rate was 0.08% within 70 minutes.

[0082] Separately, at room temperature (25±1°C), the initial paracetamol ACE concentration (C0) in simulated fresh urine (FU) was 5 μmol / L, the system pH was 6, and after thorough stirring and allowing to stand, the reaction was terminated by the addition of an equivalent amount of sodium thiosulfate as described in Example 2. The paracetamol ACE concentration (C) in the system was measured at different times to determine the degradation of paracetamol ACE over 70 minutes. The results showed that the degradation rate was 0.06% within 70 minutes.

[0083] from Figure 1The results show that the ACE degradation rates for the mixed solutions treated with PI / PB9, PB9, PB6, H2O2 / real FU, PI / real HU, PI / simulated HU, PMS / real FU, and PI / water were 61.63%, 2.34%, 4.52%, 26.34%, 45.85%, 56.56%, 60.45%, and 64.76%, respectively. The degradation rate reached 100.00% when using the PI / PB6 system. Notably, periodate PI exhibited a significant degradation effect on paracetamol ACE in real fresh urine FU (at a pH of 6), reaching 100.00% within 70 minutes. Similarly, periodate PI also exhibited a good degradation effect on paracetamol ACE in simulated fresh urine FU (at a pH of 6), achieving 100.00% degradation within 50 minutes. This indicates that the PI / FU system can effectively treat paracetamol ACE in a real urine system and has good application prospects.

[0084] Example 7:

[0085] In this example, the effect of the dosage of periodate PI on the degradation rate of paracetamol ACE was investigated.

[0086] like Figure 2 As shown, with Example 2 as a reference, the only difference is that the concentration of periodate PI in the mixed solution is changed to 0.5, 1, 2, 3, and 4 mmol / L, respectively. After 50 minutes, the degradation rates of paracetamol ACE are 52.94%, 69.63%, 100.00%, 100.00% and 100.00%, respectively.

[0087] Example 8:

[0088] like Figure 3 As shown, with Example 2 as a reference, the only difference is that the concentration of paracetamol ACE in the mixed solution is changed to 3, 5, 7, and 9 mmol / L, respectively. After 50 minutes, the paracetamol ACE degradation rates are 100.00%, 100.00%, 90.98% and 89.53%, respectively.

[0089] Example 9:

[0090] like Figure 4 As shown, with Example 2 as a reference, the only difference is that the temperature of the mixed solution is changed to 15, 25, 35 and 40°C, respectively. After 50 minutes, the degradation rates of paracetamol ACE are 79.51%, 100.00%, 100.00% and 100.00%, respectively.

[0091] Example 10:

[0092] like Figure 5As shown, with Example 2 as a reference, the only difference is that the pH value of the mixed solution is changed to 6, 7, 8 and 9, respectively. After 50 minutes, the degradation rate of paracetamol ACE decreases from 100.00% to 89.96%, 88.59%, 73.77% and 61.63%, respectively.

[0093] Example 11:

[0094] like Figure 6 As shown, with Example 2 as a reference, the only difference is that the addition method of periodate PI is changed, so that equal amounts of periodate PI are added to the mixed solution in 1, 2, 3 and 4 times, respectively. After 50 minutes, the degradation rates of ACE are 100.00%, 82.95%, 80.85% and 82.33%, respectively.

[0095] Example 12:

[0096] like Figure 7-Figure 8 As shown in the figure, paracetamol ACE and sodium periodate PI were added to fresh urine FU at room temperature (25±1℃) to ensure that their initial concentrations C0 were 5mmol / L and 2mmol / L respectively. Under the premise of ensuring that the total volume of the system was 100mL, different types of ions were added to verify their effects on ACE degradation. 44mmol / L Cl – 、15mmol / LSO4 2 – , and simultaneously add 44mmol / LCl – and 15mmol / L SO4 2– , adding 4mmol / L Ca 2+ 、4mmol / L Mg 2+ , 250mmol / L urea and 2.7mmol / L sodium citrate ions had little effect on the degradation rate of ACE after 50 minutes.

[0097] Example 13:

[0098] At room temperature (25 ± 1 ° C), paracetamol ACE and sodium periodate PI were added to real fresh urine FU to ensure that their initial concentrations C0 were 5 mmol / L and 2 mmol / L, respectively. Under the premise of ensuring that the total volume of the system was 100 mL, quenchers of different active substances were added, ascorbic acid 1, 5 and 10 mmol / L (quencher of all ROS), histidine 0.05, 0.5 and 5 mmol / L (corresponding to ROS 1 O2), phenol 0.05, 0.5 and 5 mmol / L (corresponding to ROS of IO3 and IO4), nitro blue tetrazolium 0.02, 0.05 and 0.1 mmol / L (corresponding to ROS of O2 ·-), tert-butanol 5, 10 and 15 mmol / L (corresponding to ROS is ·OH). Figures 9-11 As shown, the ROS of PI / FU system is 1 O2 and OH play the most important role 1 O2.

[0099] Example 14:

[0100] At room temperature (25±1°C), paracetamol (ACE) and sodium periodate (PI) were added to real fresh urine FU to ensure that their initial concentrations (C0) were 5 mmol / L and 2 mmol / L, respectively. Under the premise of ensuring that the total volume of the system was 100 mL, the free radical scavenger 2,2,6,6-tetramethyl-4-piperidone (TEMP) was added, and the generation of free radicals was analyzed using an electron paramagnetic resonance spectrometer. Figure 12 As shown, the electron paramagnetic resonance spectrum shows 1 The signal of O2 further proves that the main ROS in the PI / FU system is 1 O2.

[0101] In summary, the present invention discloses a method for degrading paracetamol in fresh urine using periodate, namely, a method for degrading paracetamol ACE in fresh urine FU using periodate PI. The method comprises the following steps: adding periodate PI to fresh urine FU contaminated with paracetamol ACE to be treated, and uniformly mixing to achieve rapid and efficient degradation of ACE. The PI / FU system established in the present invention can synergistically promote the generation of singlet oxygen and hydroxyl radicals, thereby achieving the purpose of rapid and efficient degradation of ACE. The present invention does not require additional energy supply or the addition of any exogenous activator, thereby greatly reducing costs, and has the advantages of efficient ACE degradation and environmental friendliness. It has broad application prospects in ensuring water ecological safety and safe resource utilization of urine.

[0102] At this point, those skilled in the art will recognize that, although the embodiments of the present invention have been shown and described in detail herein, many other variations or modifications consistent with the principles of the present invention may be directly determined or derived from the disclosure of the present invention without departing from the spirit and scope of the present invention. Therefore, the scope of the present invention should be understood and deemed to cover all such other variations or modifications.

Claims

1. A method for degrading paracetamol in fresh urine using periodate, characterized in that: The method specifically comprises the following steps: Step S1: collecting fresh urine FU, wherein the fresh urine FU contains the drug paracetamol ACE; Step S2: adding an oxidizing agent, periodate (PI), to the fresh urine FU containing the paracetamol ACE drug in step S1 at room temperature, stirring and mixing until the mixture is uniformly mixed, and then obtaining urine in which the paracetamol ACE drug has been degraded after the reaction is completed; The main components of the fresh urine FU include: urea, NaCl, Na2SO4, KCl, MgCl2•6H2O, NaH2PO4•2H2O, CaCl2, trisodium citrate dihydrate and water; The storage conditions of the fresh urine FU are: storing the urine FU at a temperature below 4°C and away from light; the time from the collection of the fresh urine FU to its use shall not exceed 24 hours; The pH value of the fresh urine FU is 6-9; The method does not require additional energy supply and does not require any external addition of any activating agent.

2. A method for degrading paracetamol in fresh urine using periodate as claimed in claim 1, characterized in that: The concentration of the drug paracetamol ACE in fresh urine FU is 3-9 mmol / L.

3. A method for degrading paracetamol in fresh urine using periodate as claimed in claim 1, characterized in that: The periodate PI includes sodium periodate.

4. A method for degrading paracetamol in fresh urine using periodate as claimed in claim 1, characterized in that: The concentration of the periodate PI in fresh urine FU is 0.5-4 mmol / L.

5. A method for degrading paracetamol in fresh urine using periodate as claimed in claim 1, characterized in that: The stirring speed is 100-300 rpm.

6. A method for degrading paracetamol in fresh urine using periodate as claimed in claim 1, characterized in that: The reaction time is 30-90 min.

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