Laboratory for feeding radioactive animals

Abstract

The invention relates to a laboratory for radioactive animal feeding, the wall thickness is determined through a scientific calculation shielding thickness formula so as to meet the shielding protection requirement of the laboratory wall, the shielding capacity for high-intensity radioactive rays is remarkably improved, meanwhile, the optimal configuration of materials is achieved, and the construction cost is reduced. The laboratory adopts a ventilation system comprising a shutter air port, an air return column and an exhaust channel, and is combined with an iodine adsorption device or an air filtering device, so that the diffusion of radioactive contamination is effectively controlled, and the air circulation efficiency is improved. In addition, by means of the design that manual glass magnesium rock wool purification materials are laid on the inner side and the outer side of the reinforced concrete wallboard and the PVC floor is in seamless connection, the strength, durability and easy-to-clean performance of the structure are enhanced, and the safety and maintenance convenience of the laboratory are further improved. According to the technical scheme, efficient protection and pollution control of the radioactive animal feeding laboratory are achieved, and the method is suitable for various application scenes in the radioactive research field.

Description

Technical Field

[0001] The invention relates to the field of biological laboratory buildings, in particular to a laboratory for raising radioactive animals. Background Art

[0002] In recent years, with the rapid development of the radiopharmaceutical research and development industry chain, the application scope of radiopharmaceuticals has continued to expand, especially in the field of tumor treatment and diagnosis, and its importance has become increasingly prominent. To support the development of this industry, my country issued the "Medium- and Long-Term Development Plan for Medical Isotopes (2021-2035)" in 2021, which further promoted the research and development of radiopharmaceuticals and their widespread application in clinical and scientific research. As innovative drugs enter the preclinical safety evaluation stage, the demand for radioactive animal experimental environments has increased significantly.

[0003] As a key infrastructure in the safety evaluation of radioactive drugs, radioactive animal breeding rooms must not only meet the strict requirements of radiation shielding and contamination protection, but also ensure the health of experimental animals and the reliability of the experimental environment. However, there are currently a limited number of facilities dedicated to radioactive animal breeding in China, and most of them have not formed standardized design and construction plans, resulting in high construction costs, uneven protection effects, and may even affect the accuracy of experimental results.

[0004] Therefore, in view of the problems existing in the design and construction of existing radioactive animal breeding rooms, a scientific, reasonable and cost-effective design of radioactive animal breeding rooms is proposed, which is of great significance for improving laboratory safety, saving construction costs and ensuring the smooth progress of experiments.

[0005] In view of the above problems, the present invention is proposed. Summary of the invention

[0006] The invention discloses a laboratory for raising radioactive animals, aiming to solve the technical problems existing in the prior art.

[0007] The present invention provides a method for constructing a laboratory for radioactive animal breeding, comprising:

[0008] The experimental area is used for the breeding and experimental operation of radioactive animals;

[0009] The wall body is provided with a first wall panel, a second wall panel and a third wall panel, the second wall panel is in a square shape, the first wall panel and the third wall panel are respectively arranged on the inner side and the outer side of the second wall panel; the thickness of the second wall panel is calculated according to the following formula:

[0010]

[0011] Where:

[0012] x is the shield thickness in millimeters (mm);

[0013] TVL is the thickness of the layer with one tenth value of the gamma ray, in millimeters (mm);

[0014] A is the maximum activity of the radioactive source used for a single animal, expressed in megabecquerel (MBq);

[0015] Γ is the ambient dose equivalent rate constant at 1 m from the source, in μSv·m 2 / MBq·h;

[0016] is the dose rate control value of the point of interest outside the shielding body, in microsievert per hour (μSv / h);

[0017] r is the distance between the reference point and the radiation source, in meters (m);

[0018] The ground is paved with a PVC floor, the PVC floor is raised at the connection between the first wall panel and the third wall panel, and is connected to the first wall panel and the third wall panel;

[0019] The return air column system includes multiple return air columns and a main exhaust passage. The multiple return air columns are arranged in the experimental area, and the main exhaust passage is arranged outside the experimental area. The multiple return air columns are connected to the main exhaust passage; louver air outlet installation areas are respectively provided on the side walls of the multiple return air columns, and louver air outlets are installed in the louver air outlet installation areas.

[0020] As a preferred technical solution, the main exhaust channel is provided with a plurality of exhaust sub-channels, and a plurality of return air columns are connected to the plurality of exhaust sub-channels.

[0021] As a preferred technical solution, the number of the multiple return air columns is the same as the number of the exhaust air sub-channels, and the number of the return air columns is 4.

[0022] As a preferred technical solution, four return air columns are respectively set at the four corners of the experimental area.

[0023] As a preferred technical solution, an iodine adsorption device or an air filtering device is provided at the end of the main exhaust passage.

[0024] As a preferred technical solution, lifting groove aluminum and aluminum ground trough are set on the inner and outer bottom of the second wall panel, the lifting groove aluminum is set above the aluminum ground trough, and the first wall panel and the third wall panel are respectively set above the lifting groove aluminum.

[0025] As a preferred technical solution, the first wall panel and the third wall panel are both made of handmade glass magnesium rock wool purification material.

[0026] As a preferred technical solution, an electric constant / variable air volume valve is installed at the confluence of multiple exhaust sub-channels, and a sealed sampling port is installed at the front end of the electric constant air volume Venturi valve.

[0027] As a preferred technical solution, the thickness of the second wall panel is 180-210 mm; the thickness of the first wall panel and the third wall panel is 50-100 mm.

[0028] As a preferred technical solution, a concave area of ​​1.5-3 mm×7-9 cm is provided at the bottom of the third wall panel, and the size of the rising area of ​​the PVC board matches the concave area.

[0029] The technical solution adopted by the present invention can achieve at least one of the following beneficial effects:

[0030] 1. This invention uses a scientific calculation of the shielding thickness formula to accurately determine the shielding protection requirements of the laboratory wall, takes the one-tenth value layer thickness (TVL) of the gamma ray as the core parameter, and combines key indicators such as the activity of the radiation source, the ambient dose equivalent rate constant, and the controlled dose rate to optimize the wall thickness design. This design effectively reduces the risk of leakage of high-intensity radiation in the laboratory, ensures the safety of the experimental environment, achieves the optimal configuration of materials, and reduces construction costs.

[0031] 2. The present invention realizes efficient circulation and external exhaust of internal air by setting up a ventilation system in which the return air column is connected to the exhaust air branch channel. In particular, the reasonable arrangement of the louvered air outlets on the side walls of the return air column and the use of an iodine adsorption device / air filter device at the end of the exhaust air main channel not only improve the ability of air filtration and adsorption of radioactive iodine, but also effectively control the spread of radioactive contamination in the experimental area, providing a safer and cleaner environment for long-term experimental operations.

[0032] 3. The present invention significantly improves the strength and installation convenience of the wall by laying handmade glass magnesium rock wool purification materials (first wall panel and third wall panel) on the inside and outside of the second wall panel, combined with the installation design of the lifting trough aluminum and the aluminum ground trough. At the same time, the design of seamless connection between the PVC floor and the wall avoids the potential risks of dust accumulation and radioactive contamination, making the floor and wall structure more durable and easy to clean. Through these integrated construction measures, the service life and maintenance convenience of the laboratory have been significantly improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following briefly introduces the drawings required for describing the embodiments, which constitute a part of the present invention. The exemplary embodiments of the present invention and their descriptions explain the present invention and do not constitute improper limitations on the present invention. In the drawings:

[0034] Figure 1It is a front view schematic diagram of a laboratory for raising radioactive animals according to the present invention;

[0035] Figure 2 For the present invention Figure 1 A is a schematic diagram of the enlarged structure of the middle part;

[0036] Figure 3 The figure is a schematic diagram of the top view of the structure of a laboratory for raising radioactive animals according to the present invention.

[0037] Description of reference numerals:

[0038] 1. Experimental area; 2. Top plate; 3. Wall; 31. First wall panel; 32. Second wall panel; 33. Third wall panel; 4. Ground; 5. Lifting trough aluminum; 6. Aluminum ground trough; 7. Return air column system; 71. First return air column; 72. Second return air column; 73. Third return air column; 74. Fourth return air column; 8. Louvered air vents. DETAILED DESCRIPTION

[0039] In order to make the purpose, technical solution and advantages of the present invention clearer, the technical solution of the present invention will be clearly and completely described below in conjunction with the specific embodiments of the present invention and the corresponding drawings. In the description of the present invention, it should be noted that the term "or" is usually used in the sense of including "and / or", unless the content clearly indicates otherwise.

[0040] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected" and "connected" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or a magnetic connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be internal communication between two elements. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances. In addition, in the description of this application, the terms "first", "second", etc. are only used to distinguish the description and cannot be understood as indicating or implying relative importance.

[0041] Obviously, the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0042] In order to solve the problems existing in the prior art, the present invention provides a laboratory for radioactive animal breeding, such as Figure 1-3As shown, it includes an experimental area 1, a ceiling 2, a wall 3 and a return air column system 7. The experimental area 1 is used for the breeding and experimental operation of radioactive animals to meet the space and functional requirements of the experiment; the ceiling 2 and the wall 3, as supporting and shielding structures, are used to isolate radioactive substances and ensure the safety of the external environment of the laboratory; the return air column system 7 is used to exhaust the air inside the laboratory through the shortest path, reduce the radiation hazards during the operation of the laboratory personnel, and maintain the air quality in the laboratory up to standard.

[0043] like Figure 1 and Figure 3 As shown, the wall 3 includes a first wall panel 31, a second wall panel 32 and a third wall panel 33. The second wall panel 32 is made of reinforced concrete and is formed by pouring. Except for the reserved door opening, the second wall panel 32 is an integrated square structure formed along the four sides of the experimental area 1. Preferably, in order to ensure structural support and shielding effect, the thickness of the second wall panel 32 is calculated by the following formula:

[0044]

[0045] Where:

[0046] x is the shield thickness in millimeters (mm);

[0047] TVL is the thickness of the layer with one tenth value of the gamma ray, in millimeters (mm);

[0048] A is the maximum activity of the radioactive source used for a single animal, expressed in megabecquerel (MBq);

[0049] Γ is the ambient dose equivalent rate constant at 1 m from the source, in μSv·m 2 / MBq·h;

[0050] is the dose rate control value of the point of interest outside the shielding body, in microsievert per hour (μSv / h);

[0051] r is the distance between the reference point and the radiation source, in meters (m).

[0052] Further preferably, the thickness of the second wall panel 32 is 180-210 mm. The first wall panel 31 and the third wall panel 33 are respectively arranged on the inner side and the outer side of the second wall panel 32. Preferably, the first wall panel 31 and the third wall panel 33 are both made of handmade glass magnesium rock wool purification material to enhance the fire resistance, corrosion resistance, moisture resistance and other protective functions of the wall 3, while improving the radiation protection effect and improving the temperature and humidity regulation ability of the indoor environment. The first wall panel 31 and the third wall panel 33 are set to a thickness of 50-100 mm according to the needs of the building. Preferably, in order to meet the ground connection requirements, the near-ground ends of the first wall panel 31 and the third wall panel 33 are set to 48-98 mm, that is, the near-ground thickness of the first wall panel 31 and the third wall panel 33 is 1.5-3 mm less than the thickness of the wall panel.

[0053] like Figure 1 and Figure 3 As shown, the return air column system 7 includes a first return air column 71, a second return air column 72, a third return air column 73, a fourth return air column 74 and a total exhaust passage (not marked in the figure). The first return air column 71, the second return air column 72, the third return air column 73, and the fourth return air column 74 are arranged inside the first wall panel 31, respectively arranged at the four corners of the experimental area 1, providing an exhaust passage for the experimental area 1; the total exhaust passage is arranged outside the experimental area 1, and is respectively connected to the above four return air columns. The two side walls of the first return air column 71, the second return air column 72, the third return air column 73 and the fourth return air column 74 are connected to the first wall panel 31, and the other two side walls are respectively provided with handmade glass magnesium rock wool purification panels to provide support and protection for the above return air columns. The first return air column 71, the second return air column 72, the third return air column 73 and the fourth return air column 74 are respectively provided with louvered air vents 8 to achieve air flow between the above return air columns and the experimental area 1. The main exhaust channel arranged outside is divided into four exhaust sub-channels outside, and the four exhaust sub-channels are respectively connected to the first return air column 71, the second return air column 72, the third return air column 73 and the fourth return air column 74. An electric fixed / variable air volume valve (not marked in the figure) is installed at the junction of the above four exhaust sub-channels for accurately adjusting the exhaust volume. A sealed sampling port is installed at the front end of the electric fixed / variable air volume valve for sampling when the electric fixed / variable air volume valve fails and needs to be disassembled and repaired.

[0054] Through the above structural design, the laboratory is reasonably arranged in space and configured in function. The experimental area 1 is the core area for radioactive feeding and experimental operation. The top plate 2 and the wall 3 serve as structural support and shielding structure. The wall 3 includes three layers. The second wall panel 32 is located in the middle and is cast in one piece with reinforced concrete to form a square shielding structure around the experimental area 1 to provide excellent radiation shielding and structural stability. The first wall panel 31 and the third wall panel 33 are respectively arranged on the inner and outer sides of the second wall panel 32. The handmade glass magnesium rock wool purification material is used, which not only improves the wall's resistance to radiation, but also improves the radiation shielding performance. Fire, corrosion and moisture-proof performance, and further optimizes the radiation protection effect and the temperature and humidity adjustment capacity of the indoor environment; the first return air column 71, the second return air column 72, the third return air column 73 and the fourth return air column 74 are arranged inside the experimental area 1, and the main exhaust channel is arranged outside, and is divided into four exhaust sub-channels, which are respectively connected to the four return air columns. Electric fixed / variable air volume valves are installed on the exhaust sub-channels to accurately adjust the exhaust volume, so as to control the air flow balance and pollutant emission in the experimental area 1; each return air column is provided with a louver vent 8 to realize the circulation between the air inside the experimental area 1 and the return air column. The embodiment of the present invention can effectively isolate radioactive substances, provide a safe and stable experimental environment, and reduce radiation hazards and maintain air quality standards through an efficient air circulation and purification system, thereby meeting the multiple needs of radioactive animal breeding and experimental operations.

[0055] In some preferred embodiments, Figure 2 As shown, the floor 4 is also included, and the floor 4 is entirely paved with a transparent PVC floor. Preferably, the floor 4 is leveled by self-leveling before the floor is laid. Further preferably, the thickness of the transparent PVC floor is 1.5-3 mm. The connection between the PVC floor and the first wall panel 31 and the third wall panel 33 is respectively set to an upward structure, which is in an arc shape, and the upward structure is connected to the bottom of the third wall panel 33. In order to increase the sealing effect, the upward structure and the third wall panel 33 are sealed with a silicone sealant.

[0056] In some preferred embodiments, the height of the rising structure of the above-mentioned PVC floor is 7-9 cm, the length of the near-ground ends of the first wall panel 31 and the third wall panel 33 is also set to 7-9 cm, and the thickness of the near-ground ends of the first wall panel 31 and the third wall panel 33 is 1.5-3 mm smaller than the thickness of the wall panel, that is, a 1.5-3 mm × 7-9 cm concave area is provided at the connection between the first wall panel 31 and the third wall panel 33 and the PVC floor, which matches the size of the rising structure of the PVC floor so as to provide for the distribution of the rising structure of the PVC floor.

[0057] In some preferred embodiments, an iodine adsorption device or an air filtering device is provided at the end of the external exhaust main passage for air purification.

[0058] In some preferred embodiments, Figure 2 As shown, the bottom of the first wall panel 31 and the third wall panel 33 close to the ground 4 is also provided with connected lifting grooves 5 and aluminum ground troughs 6 to increase the supporting strength of the wall.

[0059] In some preferred embodiments, the first return air column 71, the second return air column 72, the third return air column 73 and the fourth return air column 74 are also provided with lifting grooves 5 and aluminum ground troughs 6 at the bottom close to the ground 4 to increase the supporting strength of the side walls of the four return air columns.

[0060] The embodiment of the present invention also provides a method for constructing a laboratory for feeding radioactive animals, comprising:

[0061] Step S1: Determine the construction requirements of the radioactive animal breeding laboratory according to the special needs of the radioactive animal breeding laboratory, such as ventilation frequency, pressure requirements, lighting, temperature, humidity and shielding protection, etc.;

[0062] Step S2: According to the shielding protection requirements, the wall thickness of the laboratory is calculated using the following formula:

[0063]

[0064] Where:

[0065] x is the shield thickness in millimeters (mm);

[0066] TVL is the thickness of the layer with one tenth value of the gamma ray, in millimeters (mm);

[0067] A is the maximum activity of the radioactive source used for a single animal, expressed in megabecquerel (MBq);

[0068] Γ is the ambient dose equivalent rate constant at 1 m from the source, in μSv·m 2 / MBq·h;

[0069] is the dose rate control value of the point of interest outside the shielding body, in microsievert per hour (μSv / h);

[0070] r is the distance between the reference point and the radiation source, in meters (m);

[0071] Step S3: after reserving the door opening position according to the calculation results of the above steps, the integral square structure of the second wall panel 32 and the experimental area 1 are formed by a casting process;

[0072] Step S4: The first return air column 71, the second return air column 72, the third return air column 73 and the fourth return air column 74 are respectively arranged at the four corners of the above-mentioned square structure / experimental area 1, and the first return air column 71, the second return air column 72, the third return air column 73 and the fourth return air column 74 are connected to the four exhaust sub-channels of the external exhaust main channel to form indoor and outdoor exhaust;

[0073] Step S5: The ground 4 is leveled by self-leveling, and the lifting groove aluminum 5 and the aluminum ground trough 6 are installed on the inner and outer bottom of the second wall panel 32;

[0074] Step S6: laying handmade glass magnesium rock wool purification panels on the inner and outer sides of the second wall panel 32 and the side walls of the first return air column 71, the second return air column 72, the third return air column 73 and the fourth return air column 74; reserving louver air outlet installation areas on the side walls of the first return air column 71, the second return air column 72, the third return air column 73 and the fourth return air column 74; forming the first wall panel 31 and the third wall panel 33 on the inner and outer sides of the second wall panel 32, respectively, and laying the first wall panel 31 and the third wall panel 33 on the inner and outer sides of the second wall panel 32 above the lifting slot aluminum 5;

[0075] Step S7: laying a transparent PVC floor on the ground 4, and sealing the raised structure of the PVC floor with the first wall panel 31 and the third wall panel 33 using a silicone sealant;

[0076] Step S8: Install louver vents in the louver vent installation areas reserved on the side walls of the first return air column 71, the second return air column 72, the third return air column 73 and the fourth return air column 74; install electric fixed / variable air volume valves on the four exhaust sub-channels of the external exhaust main channel; and provide iodine adsorption devices on the top of the first return air column 71, the second return air column 72, the third return air column 73 and the fourth return air column 74, respectively.

[0077] The embodiments of the present invention are described above in conjunction with the accompanying drawings, but the present invention is not limited to the above-mentioned specific implementation modes, which are merely illustrative rather than restrictive. Under the guidance of the present invention, ordinary technicians in this field can also make many forms without departing from the scope of protection of the present invention and the claims, all of which are within the protection of the present invention.

Claims

1. A laboratory for raising radioactive animals, characterized in that: include: An experimental area, which is used for feeding and conducting experimental operations on radioactive animals; A wall body, wherein the wall body is provided with a first wall panel, a second wall panel and a third wall panel, the second wall panel is in a square shape, the first wall panel and the third wall panel are respectively arranged on the inner side and the outer side of the second wall panel; the thickness of the second wall panel is calculated according to the following formula: Where: x is the shield thickness in millimeters (mm); TVL is the thickness of the layer with one tenth value of the gamma ray, in millimeters (mm); A is the maximum activity of the radioactive source used for a single animal, expressed in megabecquerel (MBq); Γ is the ambient dose equivalent rate constant at 1 m from the source, in μSv·m 2 / MBq·h; is the dose rate control value of the point of interest outside the shielding body, in microsievert per hour (μSv / h); r is the distance between the reference point and the radiation source, in meters (m); A ground, wherein a PVC floor is laid on the ground, and the PVC floor is raised at a connection point between the first wall panel and the third wall panel, and is connected to the first wall panel and the third wall panel; The return air column system comprises a plurality of return air columns and a main exhaust passage, the plurality of return air columns are arranged in the experimental area, the main exhaust passage is arranged outside the experimental area, and the plurality of return air columns are connected to the main exhaust passage; louver air outlet installation areas are respectively provided on the side walls of the plurality of return air columns, and louver air outlets are installed in the louver air outlet installation areas.

2. The laboratory according to claim 1, characterized in that The main exhaust channel is provided with a plurality of exhaust sub-channels, and the plurality of return air columns are connected to the plurality of exhaust sub-channels.

3. The laboratory according to claim 2, characterized in that The number of the multiple return air columns is the same as the number of the exhaust air sub-channels, and the number of the return air columns is 4.

4. The laboratory according to claim 3, characterized in that The four return air columns are respectively arranged at the four corners of the experimental area.

5. The laboratory according to claim 2, characterized in that An iodine adsorption device or an air filtering device is arranged at the end of the main exhaust passage.

6. The laboratory according to claim 1, characterized in that The inner and outer bottoms of the second wall panel are provided with lifting grooves aluminum and aluminum ground troughs, the lifting grooves aluminum are provided above the aluminum ground troughs, and the first wall panel and the third wall panel are provided above the lifting grooves aluminum respectively.

7. The laboratory according to claim 6, characterized in that The first wall panel and the third wall panel are both made of handmade glass magnesium rock wool purification material.

8. The laboratory according to claim 1, characterized in that An electric fixed / variable air volume valve is installed at the confluence of the multiple exhaust sub-channels, and a sealed sampling port is installed at the front end of the electric fixed / variable air volume valve.

9. The laboratory according to any one of claims 1 to 8, characterized in that: The thickness of the second wall panel is 180-210 mm; the thickness of the first wall panel and the third wall panel is 50-100 mm.

10. The laboratory according to claim 9, characterized in that The bottom of the third wall panel is provided with a concave area of ​​1.5-3 mm×7-9 cm, and the size of the rising area of ​​the PVC board matches the concave area.

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