A kind of anti-aging functional composition
Through an anti-aging functional composition containing NMN, food PQQ, coenzyme Q10, ginseng saponin, aminobutyric acid and celery seed extract, the problem of aging caused by the inability of the human body to effectively eliminate reactive oxygen species is solved, and the effect of delaying aging is achieved.
Patent Information
- Application Number
- CN202510068909.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-01-16
- Publication Date
- 2025-04-08
AI Technical Summary
As we age, the human body's functions decline and it is impossible to effectively eliminate harmful substances such as reactive oxygen species, resulting in skin aging and other aging problems.
It provides an anti-aging functional composition, including NMN, food PQQ, coenzyme Q10, ginseng saponin, aminobutyric acid and celery seed extract. Through the synergistic action of these ingredients, it helps the body to remove stress substances and achieve the effect of delaying aging.
By increasing the synthesis rate of antioxidant substances in the body and the activity of antioxidant enzymes, it effectively eliminates oxidative active substances in the body, reduces their damage to cells, and delays the aging process.
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Abstract
Description
Technical Field
[0001] The invention relates to an anti-aging functional composition, and in particular to the field of health food anti-aging. Background Art
[0002] As the basic age continues to increase, the body's ability to independently eliminate daily body metabolism declines. When the body's ability to process itself declines, a kind of body balance will appear. The human body will produce certain oxidative active substances in the normal metabolic process, such as reactive oxygen. When there is too much reactive oxygen and it cannot be eliminated naturally by the body's functions, it will cause a certain burden on macromolecules such as human lipids and proteins, thereby causing skin aging, loss of luster and elasticity, etc.
[0003] As time goes by, it is inevitable that organisms will gradually age. At the same time, each person's living environment and age will also cause the body's ability to eliminate stress substances to be different. The present invention has well solved the problem of the body's own function declining and being unable to eliminate harmful substances such as active oxygen through its own function. Summary of the invention
[0004] In order to achieve the above purpose, the present invention provides an anti-aging functional composition, which is composed of the following composition: NMN (0.48-0.53), food PQQ (0.012-0.018), coenzyme Q10 (0.03-0.036), ginsenoside (0.113-0.118), aminobutyric acid (0.162-0.167), and celery seed extract (0.16-0.166). The multiple ingredients work synergistically with each other to effectively assist the body's functions in clearing stress substances produced by the body during the stress response process, allowing the body to reach a beneficial state of balance, thereby delaying aging.
[0005] Unless otherwise specified, the raw materials used in the embodiments and comparative examples of the present invention can be obtained through conventional purchasing channels: NMN was purchased from Bontai Bioengineering (Shenzhen) Co., Ltd., corresponding to the brand name BONTAC; food PQQ was purchased from Shandong Yuanlitai Pharmaceutical Technology Co., Ltd., corresponding to the brand name FORCE PQQ; coenzyme Q10 was purchased from Xi'an Lavia Biotechnology Co., Ltd., corresponding to the brand name Qin Weiya; ginsenosides were purchased from Ji'an Shengliyuan Ginseng Products Co., Ltd., corresponding to the brand name Shengliyuan; aminobutyric acid was purchased from Shenzhen Jinfuyuan Biotechnology Co., Ltd., corresponding to the brand Jinfuyuan; celery seed extract was purchased from Xi'an Shangcheng Biotechnology Co., Ltd., corresponding to the brand name Chongde Shangcheng.
[0006] To achieve the above-mentioned purpose, the present invention provides an anti-aging functional composition, comprising the following ingredients: NMN, food PQQ, coenzyme Q10, ginsenoside, aminobutyric acid, celery seed extract in corresponding proportions (0.48-0.53): (0.012-0.018): (0.03-0.036): (0.113-0.118): (0.162-0.167): (0.16-0.166).
[0007] At the same time, the following weight ratio groups were adopted: NMN (0.3-0.53), food PQQ (0.01-0.018), coenzyme Q10 (0.02-0.036), ginsenoside (0.01-0.118), aminobutyric acid (0.12-0.167), and celery seed extract (0.13-0.166), among which the molecular weight of coenzyme Q10 and edible PQQ is <10,000 Daltons.
[0008] Furthermore, the experimental preparation method of NMN and other combined substances is as follows:
[0009] NMN and aminobutyric acid were mixed in a mass ratio of 0.35:0.14, and supplemented with food PQQ (0.01), coenzyme Q10 (0.03), ginsenoside (0.11), and celery seed extract (0.13) and stirred evenly in a stirring pot to make equal amounts of particles. The particles were tested by biological administration, and the corresponding P value obtained by fluorescence intensity reaction was <0.05 using relevant instruments such as stereo fluorescence microscope (SZX7, Olympus, Japan), ROS detection kit, and glutathione detection.
[0010] Furthermore, the NMN and aminobutyric acid were mixed in a mass ratio of 0.42:0.14, and supplemented with food PQQ (0.012), coenzyme Q10 (0.031), ginsenoside (0.12), and celery seed extract (0.15). The experiment was repeated in the first experiment, and the P value obtained by the fluorescence intensity reaction was <0.04.
[0011] Furthermore, the NMN and aminobutyric acid were mixed in a mass ratio of 0.45:0.12, and supplemented with food PQQ (0.013), coenzyme Q10 (0.03), ginsenoside (0.3), and celery seed extract (0.14). The experiment was repeated, and the P value obtained by fluorescence intensity reaction was <0.04.
[0012] Furthermore, the NMN and aminobutyric acid were mixed in a mass ratio of 0.3:0.15, and supplemented with food PQQ (0.017), coenzyme Q10 (0.02), ginsenoside (0.01), and celery seed extract (0.16). The experiment was repeated in the first experiment, and the P value obtained by the fluorescence intensity reaction was <0.05.
[0013] Furthermore, the NMN and aminobutyric acid were mixed in a mass ratio of 0.48:0.162, and supplemented with food PQQ (0.012), coenzyme Q10 (0.03), ginsenoside (0.113), and celery seed extract (0.16). The experiment was repeated in the first experiment, and the P value obtained by the fluorescence intensity reaction was <0.02.
[0014] Furthermore, the NMN and aminobutyric acid were mixed in a mass ratio of 0.53:0.166, and supplemented with food PQQ (0.018), coenzyme Q10 (0.036), ginsenoside (0.118), and celery seed extract (0.166). The experiment was repeated by using the fluorescence intensity reaction, and the P value obtained was <0.02.
[0015] Furthermore, the NMN and aminobutyric acid were mixed in a mass ratio of 0.51:0.165, and food PQQ (0.015), coenzyme Q10 (0.032), ginsenoside (0.115), and celery seed extract (0.164) were added at the same time. The experiment was repeated through the above experiment 1, and the P value obtained by the fluorescence intensity reaction was <0.01.
[0016] The experimental data table corresponding to the anti-aging functional granule formula is as follows Figure 1 :
[0017] The anti-aging functional composition formula has a ratio of NMN, food PQQ, coenzyme Q10, ginsenoside, aminobutyric acid, and celery seed extract in the following ranges to achieve the best assistance in eliminating oxidative active substances produced in the daily metabolism of the human body, thereby achieving an anti-aging effect, (0.48-0.53): (0.012-0.018): (0.03-0.036): (0.113-0.118): (0.162-0.167): (0.16-0.166). BRIEF DESCRIPTION OF THE DRAWINGS Figure 1 : The anti-aging functional granule formula corresponds to the experimental data. The P value of experimental number 5-7 is better than that of experimental number 1-4, and the P value is <0.01~0.05. Figure 2: The effect of the sample group with the maximum safety value of 500 μg / mL concentration was different from that of the blank control group. The results showed that the anti-aging effect of 5-7 was significantly better than that of 1-4. Specific implementation plan
[0019] The specific implementation plan selected zebrafish as the experimental subject. The zebrafish were selected from adult fish that were specially raised and bred according to the experimental standards by the company, and were raised in an environment that simulated the wild. In order to make the experiment more significant, the zebrafish were specially selected to be fertilized for three days for the experiment.
[0020] The experimental zebrafish were divided into seven groups during the experiment, with 9 zebrafish in each group. The zebrafish experiment was mainly based on the fact that organisms will produce oxidatively activated substances in normal metabolism, such as reactive oxygen species (SOR). When SOR exceeds the balance of normal biological functions, it will cause damage to lipids, proteins, and biological macromolecules in cells.
[0021] If the test organism zebrafish can accelerate the synthesis rate of antioxidant substances in the body and enhance the activity of antioxidant enzymes, it can quickly eliminate ROS produced in the body, thereby reducing the level of lipid and protein peroxidation induced by ROS, and maintaining a balance between the generation and elimination of ROS in the body that is beneficial to physical health, thereby achieving an anti-aging effect.
[0022] The experimental zebrafish were divided into seven groups, each of which was further divided into three experimental groups. Each experimental group was named blank control group, positive control group, and sample treatment group. Among the three experimental groups, the blank control group was not treated in any way, glutathione was added to the positive control group, and the test solution was added to the sample treatment group. The invention contents 1-7 consist of a total of seven groups of test particles, which are easily soluble in water and can be evenly distributed during preparation. When the samples were not in contact with other anti-aging solutions, blank samples and samples in contact with the test particle solution were made. After a period of culture, the zebrafish were subjected to SOR detection and observed using the stereo fluorescence microscope mentioned above.
[0023] Data analysis and processing:
[0024] The data analysis was mainly performed using SPSS26 software, and GraphPad Prism8 was used for drawing. The data statistics were expressed as mean ± standard deviation. The experimental results were tested for normal distribution using SPSS software. If the data conformed to the normal distribution, the T parameter test or analysis of variance (ANOVA) was used for significance. If it did not conform to the normal distribution, a non-parametric test was used.
[0025] The corresponding numerical comparison results produced by the experiment show that the fluorescence reaction intensity of the sample treatment group is significantly reduced compared with the blank control group, indicating that the test samples in the sample treatment group have obvious anti-aging effects.
[0026] Specific implementation content comparison:
[0027] In the experiment, the sample group with the maximum safety value of 500 μg / mL concentration was used as the blank control group. The experimental controls for each group are as follows: Figure 2 :
[0028] The test results indicate that the anti-aging functional composition formula disclosed in the present invention has good effects in experimental numbers 5-7 and test results 5-8. It can be seen from the experimental cases implemented above that the technical solution disclosed in the present invention is not a limitation on the protection scope of the present invention. Although the present invention is described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solution of the present invention can be modified in proportion or replaced by equivalents without departing from the essence and scope of the technical solution of the present invention.
Claims
1. An anti-aging composition is mainly characterized in that the main components of the anti-aging composition are NMN, food PQQ, coenzyme Q10, ginsenoside, aminobutyric acid, and celery seed extract, which are mixed and stirred evenly in a stirring pot to form particles in relative proportions.
2. The NMN is purified by the whole enzyme method.
3. The corresponding ratios of NMN: food PQQ: coenzyme Q10: ginsenoside: aminobutyric acid: celery seed extract in the particles are (0.48-0.53): (0.012-0.018): (0.03-0.036): (0.113-0.118): (0.162-0.167): (0.16-0.168).
4. The anti-aging formula according to claim 1, wherein Food PQQ, the molecular weight of this ingredient is <8000Da.
5. The anti-aging formula according to claim 1, characterized in that The synergistic combination of any one or more anti-aging compositions of 1-6 can effectively remove active oxygen and thus delay aging.
6. The anti-aging functional composition according to claim 1, characterized in that: The anti-aging composition accounts for 85%-90% of the total ingredients.
7. The anti-aging composition according to claim 1, characterized in that: The anti-aging functional particle composition is easily soluble in water and easily absorbed by the human body.
8. According to the anti-aging composition of claim 1, a certain dose of the composition is mixed and formulated into a granule composition containing a corresponding amount, and the optimal dosage can be determined according to each person's age and physical condition. The composition can also be made into corresponding tablets, capsules, granules, pills or oral liquids.