Blood glucose monitoring device and method

Abstract

The application discloses a blood glucose monitoring device and method, wherein a tissue fluid gathering module in the device is connected between a control module and a first sensor, and is used for gathering subcutaneous tissue fluid under the control of the control module; the first sensor is used for electrochemically reacting with a skin surface of the gathered subcutaneous tissue fluid to output a first current; a second sensor is connected with a reference electrode, and is used for electrochemically reacting with a skin surface adhered to the reference electrode to output a second current; a first voltage detection module is connected between the first sensor and the control module, and is used for monitoring a first voltage value of the first current and sending the first voltage value to the control module; a second voltage detection module is connected between the second sensor and the control module, and is used for monitoring a second voltage value of the second current and sending the second voltage value to the control module; and the control module is used for acquiring a blood glucose concentration value according to the first voltage value and the second voltage value.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical health monitoring, and more particularly, to a blood glucose monitoring device and method. BACKGROUND

[0002] Blood glucose monitoring is of vital importance to the treatment and management of diabetes. Current blood glucose monitoring methods mainly include two types, one is a traditional blood glucose monitoring method, and the other is a continuous glucose monitoring (CGM) method. The traditional blood glucose monitoring method, such as fingertip capillary blood glucose monitoring, can provide accurate blood glucose readings, but it needs to repeatedly prick the skin to collect blood, which brings inconvenience and pain to patients and seriously affects the compliance of patients. The continuous glucose monitoring (CGM) method, such as blood glucose monitoring on the skin surface by collecting skin interstitial fluid, does not need to prick the skin and can provide continuous and comprehensive all-day blood glucose information, but this detection method is often contaminated by secretions such as sweat and uric acid on the skin surface, which produces interference current and seriously affects the accuracy of blood glucose monitoring. SUMMARY

[0003] An object of embodiments of the present application is to provide a new technical solution for blood glucose monitoring.

[0004] According to a first aspect of the present application, a blood glucose monitoring device is provided, comprising: an interstitial fluid collection module, a first sensor, a second sensor, a first voltage detection module, a second voltage detection module, a reference electrode, a control module, wherein:

[0005] The interstitial fluid collection module is connected between the control module and the first sensor, and is used to collect subcutaneous interstitial fluid under the control of the control module.

[0006] The first sensor is used to generate an electrochemical reaction with the skin surface of the subcutaneous interstitial fluid collected by the interstitial fluid collection module to output a first current.

[0007] The second sensor is connected with the reference electrode, and the second sensor is used to generate an electrochemical reaction with the skin surface fitted with the reference electrode to output a second current.

[0008] The first voltage detection module is connected between the first sensor and the control module, and is used to monitor a first voltage value of the first current and send the first voltage value to the control module.

[0009] The second voltage detection module is connected between the second sensor and the control module, and is used to monitor a second voltage value of the second current and send the second voltage value to the control module.

[0010] The control module is configured to obtain a blood glucose concentration value according to the first voltage value and the second voltage value.

[0011] Optionally, the first voltage detection module and the second voltage detection module are the same, and the device further comprises a gating module, the first voltage detection module is connected between the control module and the gating module, and the control module is connected to a control end of the gating module to control the gating module to gate the first sensor and the second sensor at different times.

[0012] Optionally, the interstitial fluid gathering module comprises a boosting circuit and a gathering electrode, the boosting circuit is connected between the control module and a first end of the gathering electrode, a second end of the gathering electrode is connected to the first sensor, and the gathering electrode gathers subcutaneous interstitial fluid under the boosting of the boosting circuit.

[0013] Optionally, the device further comprises a communication module, the communication module is connected to the control module, and the communication module is configured to send the first voltage value and the second voltage value to a target device under the control of the control module.

[0014] The control module is configured to receive a blood glucose concentration value returned by the target device for the first voltage value and the second voltage value through the communication module.

[0015] According to a second aspect of the present application, a blood glucose monitoring method is provided, which is applied to the device of the first aspect, and the method comprises the following steps.

[0016] In the case that the control module controls the interstitial fluid gathering module to gather subcutaneous interstitial fluid, a first voltage value detected by the first voltage detection module and a second voltage value detected by the second voltage detection module are obtained.

[0017] According to the first voltage value and the second voltage value, a blood glucose concentration value is determined.

[0018] Optionally, the method further comprises the following steps.

[0019] In the case that the control module does not control the interstitial fluid gathering module to gather subcutaneous interstitial fluid, a third voltage value detected by the first voltage detection module and a fourth voltage value detected by the second voltage detection module are obtained.

[0020] The step of determining the blood glucose concentration value according to the first voltage value and the second voltage value comprises the following steps.

[0021] The step of determining the blood glucose concentration value according to the first voltage value, the second voltage value, the third voltage value and the fourth voltage value.

[0022] Optionally, the determining the blood glucose concentration value according to the first voltage value, the second voltage value, the third voltage value and the fourth voltage value comprises:

[0023] determining a first current value according to the first voltage value and the third voltage value;

[0024] determining a second current value according to the second voltage value and the fourth voltage value;

[0025] determining a target current value according to the first current value and the second current value; wherein the target current value is a current difference value between the first current value and the second current value;

[0026] determining a blood glucose concentration value corresponding to the target current value according to a preset mapping relationship and the target current value; wherein the preset mapping relationship is a corresponding relationship between current and blood glucose concentration.

[0027] Optionally, the method further comprises:

[0028] receiving a sampling parameter; wherein the sampling parameter comprises a sampling start time and a sampling time interval;

[0029] determining a plurality of sampling times in response to the sampling parameter;

[0030] controlling the interstitial fluid gathering module not to gather subcutaneous interstitial fluid in a case where the sampling start time is reached;

[0031] controlling the interstitial fluid gathering module to gather subcutaneous interstitial fluid in a case where a sampling time other than the sampling start time is reached.

[0032] Optionally, after the controlling the interstitial fluid gathering module to gather subcutaneous interstitial fluid, the method further comprises:

[0033] in a case where the control duration is greater than or equal to a preset duration, performing the steps of acquiring the first voltage value monitored by the first voltage detection module and the second voltage value monitored by the second voltage detection module.

[0034] Optionally, the first voltage detection module and the second voltage detection module are the same, and the device further comprises a gating module, the first voltage detection module is connected between the control module and the gating module, and the control module is connected to the control end of the gating module, for controlling the gating module to select the first sensor and the second sensor at different times, respectively. The method further comprises:

[0035] controlling the gating module to sequentially select the first sensor and the second sensor in a case where any sampling time of the plurality of sampling times is reached.

[0036] An advantage of the present application is that by providing the reference electrode and the second sensor, a channel for the secretion of sweat, uric acid and the like on the skin surface to electrochemically react with the glucose reaction enzyme on the second sensor is provided, and by providing the second voltage detection module, the second voltage value corresponding to the noise current generated by the electrochemical reaction can be detected, so that the first voltage value can be corrected and calculated based on the second voltage value corresponding to the noise current in blood glucose monitoring, so as to avoid the influence of the secretion of sweat, uric acid and the like on the skin surface on the accuracy of blood glucose monitoring, improve the accuracy of blood glucose monitoring, and in addition, the blood glucose monitoring method does not need to penetrate the skin and will not affect the compliance of the patient. BRIEF DESCRIPTION OF DRAWINGS

[0037] The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments of the application and, together with the description, serve to explain the principles of the application.

[0038] Figure 1 is a structural schematic diagram of a blood glucose monitoring device according to an embodiment of the present application;

[0039] Figure 2 is a structural schematic diagram of a blood glucose monitoring device according to another embodiment of the present application;

[0040] Figure 3 is a flowchart of a blood glucose monitoring method according to an embodiment of the present application;

[0041] Figure 4 is a flowchart of a blood glucose monitoring method according to an embodiment of the present application. DETAILED DESCRIPTION

[0042] Various exemplary embodiments of the present application will now be described in detail with reference to the accompanying drawings. Note that the relative arrangement, numerical expressions, and numerical values of components and steps set forth in these embodiments are not limiting to the scope of the present application unless otherwise specifically stated.

[0043] The following description of at least one exemplary embodiment is merely illustrative in nature and is in no way limiting to the scope of the application or its applications or uses.

[0044] Techniques, methods, and apparatus known to those of ordinary skill in the relevant art can not be discussed in detail herein, but should be considered as part of the specification, where appropriate.

[0045] In all examples shown and discussed herein, any specific values should be interpreted as merely illustrative and not as a limitation. Thus, other examples of the exemplary embodiments can have different values.

[0046] It should be noted that like numerals and letters refer to like items throughout the several views, as such, once an item is defined in one view, it need not be discussed further in subsequent views.

[0047] The treatment of diabetes requires long-term monitoring of blood glucose levels in order to adjust the treatment regimen to achieve blood glucose control targets and reduce the risk of complications. At present, blood glucose monitoring methods mainly include traditional blood glucose monitoring methods and non-invasive continuous glucose monitoring (CGM) methods. Among them, the traditional blood glucose monitoring method, such as finger capillary blood glucose monitoring, can provide accurate blood glucose readings, but it needs to repeatedly prick the skin to collect blood, which brings inconvenience and pain to the patient and seriously affects the patient's compliance. The non-invasive continuous glucose monitoring (CGM) method, such as the skin surface blood glucose monitoring after collecting the skin tissue fluid, does not need to prick the skin and can provide continuous and comprehensive all-day blood glucose information. However, this monitoring method is often disturbed by the secretions such as sweat and uric acid on the skin surface, because these secretions will react with the glucose sensor to produce interference current, thereby seriously affecting the accuracy of blood glucose monitoring.

[0048] Therefore, how to accurately measure the glucose level in the tissue fluid without penetrating the skin while avoiding the influence of the secretions on the skin surface on the blood glucose measurement results has become a technical problem to be solved urgently.

[0049] In view of the above technical problems, the embodiments of the present disclosure relate to a new blood glucose monitoring device technical scheme. Figure 1 The structure schematic diagram of the blood glucose monitoring device 100 according to some embodiments is shown. As shown in the figure, the blood glucose monitoring device 100 includes a tissue fluid collection module 11, a first sensor 12, a second sensor 13, a first voltage detection module 15, a second voltage detection module 16, a reference electrode 14, and a control module 10. Figure 1

[0050] The control module 10 can be a microprocessor (Microprocessor), a digital signal processor (DSP), a programmable logic controller (PLC), etc., and those skilled in the art should understand that the specific type of the control module is not limited herein.

[0051] The first sensor 12 and the second sensor 13 can both be glucose sensors. The glucose sensor carries a glucose enzyme, which can react with glucose to produce a reaction current.

[0052] The first voltage detection module 15 and the second voltage detection module 16 can both be high-precision voltage acquisition modules such as AFE (Analog Front End). ​

[0053] The tissue fluid gathering module 11 is connected between the control module 10 and the first sensor 12, and is used to gather subcutaneous tissue fluid under the control of the control module 10.

[0054] Specifically, the skin-adhering end of the tissue fluid gathering module 11 is used to adhere to the skin, the first connecting end of the tissue fluid gathering module 11 is connected to the first end of the control module 10, and the tissue fluid gathering module 11 is used to gather subcutaneous tissue fluid at the skin adhered by the skin-adhering end of the tissue fluid gathering module 11 under the control of the control module 10. The second connecting end of the tissue fluid gathering module 11 is connected to the first connecting end of the first sensor 12. The first sensor 12 is used to electrochemically react with the skin surface of the subcutaneous tissue fluid gathered by the tissue fluid gathering module 11 (i.e., the skin surface adhered by the skin-adhering end of the tissue fluid gathering module 11) to output a first current.

[0055] The second sensor 13 is connected to the reference electrode 14, and the second sensor 13 is used to electrochemically react with the skin surface adhered by the reference electrode 14 to output a second current.

[0056] Specifically, the reference electrode 14 can also adhere to the skin, the first end of the second sensor 13 is connected to the reference electrode 14, and the second sensor 13 can electrochemically react with the sweat, uric acid, and other excretion substances of the skin surface adhered by the reference electrode 14 to output the second current. The second current here can also be referred to as a noise current.

[0057] The first voltage detection module 15 is connected between the first sensor 12 and the control module 10, and is used to monitor a first voltage value of the first current and send the first voltage value to the control module 10. The second voltage detection module 16 is connected between the second sensor 13 and the control module 10, and is used to monitor a second voltage value of the second current and send the second voltage value to the control module 10.

[0058] Specifically, one end of the first voltage detection module 15 is connected to the second end of the control module 10, and the other end is connected to the second end of the first sensor 12. One end of the second voltage detection module 16 is connected to the third end of the control module 10, and the other end is connected to the second end of the second sensor 13. When the first current flows through the first voltage detection module 15, the first current will generate a voltage drop when passing through the first voltage detection module 15 due to the large internal resistance of the first voltage detection module 15. Therefore, the first voltage value can be obtained by detecting the voltage drop through the first voltage detection module 15. Similarly, the second voltage detection module 16 can also detect the voltage drop generated when the second current flows through the second voltage detection module 16 to obtain the second voltage value.

[0059] In some embodiments, in order to avoid the influence of the type difference (i.e., the internal resistance difference) of the first voltage detection module and the second voltage detection module on the accuracy of blood glucose monitoring, the first voltage detection module and the second voltage detection module can be set as the same type and the same specification of voltage detection modules (i.e., voltage detection modules with the same internal resistance).

[0060] The control module 10 is configured to obtain a blood glucose concentration value according to the first voltage value and the second voltage value.

[0061] For example, the internal resistance of the first voltage detection module and the second voltage detection module is the same, and after the control module receives the first voltage value and the second voltage value, since the second voltage value is the voltage value corresponding to the noise current (i.e., the second current), the first voltage value and the second voltage value can be subtracted to obtain an actual voltage value, and then according to the internal resistance value of the first voltage detection module or the second voltage detection module, the actual voltage value is converted into an actual current value, and according to the actual current value and the preset corresponding relationship between the current and the blood glucose concentration, the blood glucose concentration value corresponding to the actual current value is determined.

[0062] According to the embodiments of the present application, by setting the reference electrode and the second sensor, a channel for the secretion such as sweat and uric acid on the skin surface to react with the glucose reaction enzyme on the second sensor to generate an electrochemical reaction is provided, and by setting the second voltage detection module, the second voltage value corresponding to the noise current generated by the electrochemical reaction can be detected, so that the first voltage value can be corrected and calculated based on the second voltage value corresponding to the noise current in the blood glucose monitoring, to avoid the influence of the secretion such as sweat and uric acid on the skin surface on the accuracy of blood glucose monitoring, thereby improving the accuracy of blood glucose monitoring. In addition, the blood glucose monitoring method does not need to penetrate the skin, and will not affect the compliance of the patient.

[0063] In some embodiments, as shown in FIG. 1, the first voltage detection module 15 and the second voltage detection module 16 are the same, that is, there is only one voltage detection module in the blood glucose monitoring device, which can be the first voltage detection module or the second voltage detection module, and herein only the first voltage detection module 15 is taken as an example. Figure 2

[0064] The blood glucose monitoring device 100 further includes a gating module 17, the first voltage detection module 15 is connected between the control module 10 and the gating module 17, and the control end of the control module 10 is connected to the gating module 17, for controlling the gating module 17 to gate the first sensor 12 and the second sensor 13 at different times, respectively.

[0065] ​Specifically, one end of the first voltage detection module 15 is connected with the second end of the control module 10, and the other end is connected with the first connection end of the gating module 17, and the second connection end of the gating module 17 can be switched between the first sensor 12 and the second sensor 13. The third end of the control module 10 is connected with the control end of the gating module 17, and the control module 10 can control the second connection end of the gating module 17 to select the first sensor 12 and the second sensor 13 at different time. When the second connection end of the gating module 17 selects the first sensor 12, the voltage value detected by the first voltage detection module 15 is the first voltage value corresponding to the first current, and when the second connection end of the gating module 17 selects the second sensor 13, the voltage value detected by the first voltage detection module 15 is the second voltage value corresponding to the second current.

[0066] According to the embodiment of the present application, by setting one voltage detection module and selecting the first sensor and the second sensor through the gating module to obtain the first voltage value and the second voltage value, the hardware quantity of the blood glucose monitoring device can be reduced without affecting the voltage collection of the first voltage value and the second voltage value, and the cost can be saved.

[0067] In some embodiments, the tissue fluid gathering module 11 includes a boosting circuit 111 and a gathering electrode 112, the boosting circuit 111 is connected between the control module 10 and the first end of the gathering electrode 112, the second end of the gathering electrode 112 is connected with the first sensor 12, and the gathering electrode 112 gathers subcutaneous tissue fluid under the boosting of the boosting circuit 111.

[0068] In the embodiment, the skin fitting end of the tissue fluid gathering module 11 is the skin fitting end of the gathering electrode 112, which is used to fit with the skin. The first connection end of the tissue fluid gathering module 11 is connected with the first end of the control module 10, that is, the first connection end of the boosting circuit 111 is connected with the first end of the control module 10. The second connection end of the boosting circuit 111 is connected with the first end of the gathering electrode. The second connection end of the tissue fluid gathering module 11 is connected with the first connection end of the first sensor 12, that is, the second end of the gathering electrode 12 is connected with the first connection end of the first sensor 12. The boosting circuit 111 is used to boost the gathering electrode 112 to form an electric field to gather the subcutaneous tissue fluid of the skin fitted with the gathering electrode 112.

[0069] According to the embodiment of the present application, the boosting circuit forms an electric field at the gathering electrode to gather tissue fluid, which can facilitate the gathering of subcutaneous tissue fluid, and the boosting circuit is relatively easy to control, which can facilitate user operation.

[0070] In some embodiments, the blood glucose monitoring device 100 further comprises a communication module 18 connected with the control module 10, the communication module 18 is configured to send the first voltage value and the second voltage value to a target device under the control of the control module 10, and the control module 10 is configured to receive the blood glucose concentration value returned by the target device for the first voltage value and the second voltage value through the communication module 18.

[0071] In this embodiment, the communication module 18 can be a wireless communication module, such as a wifi communication module, a Bluetooth module, etc., or a wired communication module, such as a USB communication module, etc., or other communication modules.

[0072] In the example of the blood glucose monitoring device as shown in Figure 2 The communication module 18 can be connected with the fourth end of the control module 10.

[0073] The control module 10 can control the communication module 18 to send the first voltage value and the second voltage value to the target device. The target device can be an electronic device, such as a mobile phone, a computer, etc., or a server, which is not limited here.

[0074] In the case of an electronic device as the target device, the electronic device can also communicate with the server to upload the first voltage value and the second voltage value to the server through the electronic device.

[0075] After receiving the first voltage value and the second voltage value, the target device can obtain the blood glucose concentration value according to the first voltage value and the second voltage value. The target device can send the blood glucose concentration value returned for the first voltage value and the second voltage value to the control module 10 through the communication module 18.

[0076] In some examples, the blood glucose monitoring device further comprises a display module.

[0077] In this example, after the control module receives the blood glucose concentration value returned by the target device for the first voltage value and the second voltage value, the control module can also control the display module to display the blood glucose concentration value.

[0078] In some examples, the target device can also be connected to a medical platform such as a hospital consultation platform, and when the target device returns the blood glucose concentration value to the control module, it can also send the blood glucose concentration value to the medical platform, so that the medical platform can make medical recommendations to the user according to the blood glucose concentration value.

[0079] According to the embodiments of the present application, by setting the communication module to upload the first voltage value and the second voltage value to the target device, the target device can calculate the blood glucose concentration value, which can reduce the power consumption of the blood glucose monitoring device and prolong the battery life.

[0080] Figure 3A blood glucose monitoring method is shown, applied to a blood glucose monitoring device as shown in Figure 1 or Figure 2 The control module of the blood glucose monitoring device as shown in Figure 1 or Figure 2 The method comprises steps S3100 and S3200.

[0081] Step S3100, in the case of controlling the tissue fluid aggregation module 11 to aggregate subcutaneous tissue fluid, acquiring the first voltage value detected by the first voltage detection module 15 and the second voltage value detected by the second voltage detection module 16.

[0082] In this embodiment, the first voltage detection module and the second voltage detection module can be the same as shown in Ritek 2, that is, Figure 2 The first voltage detection module in the first voltage detection module and the second voltage detection module can be the first voltage detection module, or the second voltage detection module. The first voltage detection module and the second voltage detection module can also be different as shown in Figure 1 not the same, which is not limited here.

[0083] When the user completes the blood glucose monitoring device with the skin, the tissue fluid aggregation module 11 can be controlled to aggregate subcutaneous tissue fluid to obtain the first voltage value and the second voltage value.

[0084] Those skilled in the art should understand that the specific method of controlling the tissue fluid aggregation module 11 to aggregate subcutaneous tissue fluid in step S3100 is not limited, that is, it can be controlled to aggregate subcutaneous tissue fluid at a specific time, or it can be controlled to aggregate subcutaneous tissue fluid after receiving an aggregation instruction, or it can be other control methods, which is not limited here.

[0085] Step S3200, determining the blood glucose concentration value according to the first voltage value and the second voltage value.

[0086] For example, the internal resistance of the first voltage detection module and the second voltage detection module is the same, after the control module acquires the first voltage value and the second voltage value, since the second voltage value is the voltage value corresponding to the noise current (i.e. the second current), the first voltage value and the second voltage value can be subtracted to obtain the actual voltage value, and then according to the internal resistance value of the first voltage detection module or the second voltage detection module, the actual voltage value is converted into the actual current value, and according to the corresponding relationship between the preset current and the blood glucose concentration, the blood glucose concentration value corresponding to the actual current value is determined.

[0087] According to the embodiments of the present application, the first voltage value detected by the first voltage detection module 15 and the second voltage value detected by the second voltage detection module 16 are obtained when the subcutaneous tissue fluid is aggregated by the control tissue fluid aggregation module 11, and the blood glucose concentration value is determined according to the first voltage value and the second voltage value. The second voltage value generated by the electrochemical reaction of the sweat, uric acid and other secretions on the surface of the skin can be introduced into the calculation process of the blood glucose concentration value to correct the first voltage value, so that the influence of the sweat, uric acid and other secretions on the surface of the skin on the accuracy of blood glucose monitoring can be avoided, the accuracy of blood glucose monitoring is improved, and in addition, the blood glucose monitoring method does not need to penetrate the skin and will not affect the compliance of the patient.

[0088] In theory, the third voltage value detected by the first voltage detection module and the fourth voltage value detected by the second voltage detection module should be the same when the subcutaneous tissue fluid is not aggregated by the control tissue fluid aggregation module. However, since the blood glucose monitoring device 100 includes the first sensor and the second sensor, although both sensors are glucose sensors, it is almost impossible for the two sensors to be completely the same, that is, the degree of reaction with glucose of the first sensor and the second sensor may be different, and the third voltage value and the fourth voltage value measured correspondingly will also be different, and if the blood glucose concentration value is calculated directly by the first voltage value and the second voltage value, the problem of inaccurate blood glucose monitoring caused by the hardware difference of the first sensor and the second sensor itself will exist. In order to solve this problem, in some embodiments, the method further includes step S4100.

[0089] Step S4100, the third voltage value detected by the first voltage detection module 15 and the fourth voltage value detected by the second voltage detection module 16 are obtained when the subcutaneous tissue fluid is not aggregated by the control tissue fluid aggregation module 11.

[0090] In this embodiment, the third voltage value is the voltage error value of the first sensor, and the fourth voltage value is the voltage error value of the second sensor.

[0091] In these embodiments, the blood glucose concentration value is determined according to the first voltage value and the second voltage value in step S3200, including step S4200.

[0092] Step S4200, the blood glucose concentration value is determined according to the first voltage value, the second voltage value, the third voltage value and the fourth voltage value.

[0093] For example, the first voltage value can be subtracted by the third voltage value to obtain a first actual voltage value, the second voltage value can be subtracted by the fourth voltage value to obtain a second actual voltage value, and then the first actual voltage value can be subtracted by the second actual voltage value to obtain a voltage value after noise reduction. The voltage value after noise reduction is divided by the internal resistance value of the voltage detection module to obtain a current value after noise reduction. According to the current value after noise reduction, a corresponding blood glucose concentration value is determined.

[0094] In some embodiments, the step S4200 of determining the blood glucose concentration value according to the first voltage value, the second voltage value, the third voltage value and the fourth voltage value comprises steps S4200.1-S4200.4.

[0095] In step S4200.1, the first current value is determined according to the first voltage value and the third voltage value.

[0096] In this embodiment, the first actual voltage value is determined according to the voltage difference between the first voltage value and the third voltage value. Then, the first actual voltage value is divided by the internal resistance value of the first voltage detection module to obtain the first current value.

[0097] In step S4200.2, the second current value is determined according to the second voltage value and the fourth voltage value.

[0098] In this embodiment, the second actual voltage value is determined according to the voltage difference between the second voltage value and the fourth voltage value. Then, the second actual voltage value is divided by the internal resistance value of the second voltage detection module to obtain the second current value.

[0099] In step S4200.3, the target current value is determined according to the first current value and the second current value.

[0100] In this embodiment, the target current value is the current difference between the first current value and the second current value.

[0101] In step S4200.4, the blood glucose concentration value corresponding to the target current value is determined according to a preset mapping relationship and the target current value.

[0102] In this embodiment, the preset mapping relationship is the corresponding relationship between the current and the blood glucose concentration. That is, for a current value, there is a blood glucose concentration value corresponding to it.

[0103] In some embodiments, the method further comprises steps S5100-S5400.

[0104] In step S5100, a sampling parameter is received.

[0105] In this embodiment, the sampling parameter comprises a sampling start time and a sampling time interval.

[0106] In some examples, the sampling parameter is transmitted by the target device, such as an electronic device, to a control module of the blood glucose monitoring apparatus.

[0107] In some other examples, the blood glucose monitoring apparatus comprises an input module for a user to input the sampling parameter.

[0108] At step S5200, a plurality of sampling time instants are determined in response to the sampling parameter.

[0109] For example, if the sampling start time instant is 0:00 and the sampling time interval is 1h, then the plurality of sampling time instants are 0:00, 1:00, 2:00, 3:00...23:00, 0:00.

[0110] At step S5300, the interstitial fluid collection module 11 is controlled not to collect subcutaneous interstitial fluid if the current time instant reaches the sampling start time instant.

[0111] Continuing the above example, if the sampling start time instant is 0:00, then the interstitial fluid collection module is controlled not to collect subcutaneous interstitial fluid when the current time instant reaches 0:00.

[0112] In the above embodiment where the interstitial fluid collection module comprises a boost circuit and a collection electrode, the control of the interstitial fluid collection module not to collect subcutaneous interstitial fluid comprises:

[0113] The boost circuit is controlled not to boost the collection electrode.

[0114] At step S5400, the interstitial fluid collection module 11 is controlled to collect subcutaneous interstitial fluid if the current time instant reaches a non-sampling start time instant among the plurality of sampling time instants.

[0115] Continuing the above example, if the sampling start time instant is 0:00 and the sampling time interval is 1h, then the plurality of sampling time instants are 0:00, 1:00, 2:00, 3:00...23:00, 0:00. The interstitial fluid collection module is controlled to collect subcutaneous interstitial fluid when the current time instant reaches 1:00, 2:00, etc.

[0116] In the above embodiment where the interstitial fluid collection module comprises a boost circuit and a collection electrode, the control of the interstitial fluid collection module to collect subcutaneous interstitial fluid comprises:

[0117] The boost circuit is controlled to boost the collection electrode.

[0118] The collected subcutaneous tissue fluid has a direct impact on blood glucose monitoring. In order to avoid the problem that the amount of collected subcutaneous tissue fluid is small due to the short duration of the subcutaneous tissue fluid collection module collecting subcutaneous tissue fluid, thereby reducing the accuracy of blood glucose monitoring, the embodiment of the application sets a theoretical duration of tissue fluid collection, that is, a preset duration, so that when the control duration of the subcutaneous tissue fluid collection module collecting subcutaneous tissue fluid reaches the preset duration, the first voltage value and the second voltage value are detected.

[0119] Based on this, in some embodiments, after controlling the subcutaneous tissue fluid collection module to collect subcutaneous tissue fluid in step S3100 or step S5400, the method further comprises:

[0120] In the case where the control duration is greater than or equal to the preset duration, the step of obtaining the first voltage value monitored by the first voltage detection module and the second voltage value monitored by the second voltage detection module is performed.

[0121] In the embodiment, the preset duration can be the duration required for the corresponding subcutaneous tissue fluid collection module to collect subcutaneous tissue fluid when the first voltage value tends to be stable during the historical subcutaneous tissue fluid collection process.

[0122] In the above-mentioned embodiment in which the control of the subcutaneous tissue fluid collection module to collect subcutaneous tissue fluid includes controlling the voltage boosting circuit to perform voltage boosting on the collection electrode, the control duration can be the duration of the voltage boosting circuit performing voltage boosting on the collection electrode.

[0123] In the above-mentioned embodiment in which the first voltage detection module and the second voltage detection module correspond to the same one, and the blood glucose monitoring device further comprises a gating module, the method further comprises:

[0124] In the case where any sampling time point is reached among the plurality of sampling time points, the gating module is controlled to sequentially gate the first sensor 12 and the second sensor 13.

[0125] Continuing the above example, the plurality of sampling time points are 0:00, 1:00, 2:00, 3:00...23:00, 0:00. When the starting sampling time point 0:00 is reached at the current time, the first sensor and the second sensor are sequentially gated by the gating module, and the third voltage value and the fourth voltage value can be obtained. When 1:00 is reached at the current time, the first sensor and the second sensor are sequentially gated by the gating module, and the first voltage value and the second voltage value can be obtained.

[0126] In some embodiments, in order to reduce the power consumption of the blood glucose monitoring device, in the case where any sampling time point is reached among the plurality of sampling time points, the first sensor and the second sensor are respectively controlled to electrochemically react with the skin.

[0127] In this embodiment, the glucose reaction enzyme on the first sensor and the second sensor can be triggered to electrochemically react with the skin by issuing a trigger instruction to the first sensor and the second sensor.

[0128] As shown in Figure 4 a blood glucose monitoring method is shown. The method is performed by a control module of a blood glucose monitoring device, and includes steps S1-S13.

[0129] Step S1, receiving a sampling parameter sent by an electronic device.

[0130] In this example, the sampling parameter includes a sampling start time and a sampling time interval.

[0131] In other examples, a user input sampling parameter can also be received.

[0132] Step S2, in response to the sampling parameter, determining a plurality of sampling times.

[0133] For example, the sampling start time is 0:00 and the sampling time interval is 1h, then the plurality of sampling times are 0:00, 1:00, 2:00, 3:00...23:00, 0:00.

[0134] Step S3, whether the current time reaches the sampling start time; if yes, execute step S4, if no, return to step S3.

[0135] Step S4, sending a trigger instruction to the first sensor and the second sensor respectively to trigger the electrochemical reaction.

[0136] In this example, the first sensor and the skin are triggered to electrochemically react, generating a reverse current, and the second sensor and the skin are triggered to electrochemically react, generating a reverse current.

[0137] Step S5, gating the first sensor to obtain a third voltage value detected by the first voltage detection module.

[0138] In this example, the third voltage value is the voltage value corresponding to the reverse current generated by the electrochemical reaction between the first sensor and the skin.

[0139] Step S6, gating the second sensor to obtain a fourth voltage value detected by the first voltage detection module.

[0140] In this example, the fourth voltage value is the voltage value corresponding to the reverse current generated by the electrochemical reaction between the second sensor and the skin.

[0141] Step S7, whether the current time reaches a non-sampling start time in the plurality of sampling times; if yes, execute step S8, if no, return to step S7.

[0142] Step S8, control the boost circuit to boost the aggregation electrode, and send trigger instructions to the first sensor and the second sensor respectively to trigger the electrochemical reaction.

[0143] The electrochemical reaction triggered in this step is basically the same as in step S4, which will not be repeated here.

[0144] Step S9, control whether the time length is greater than or equal to the preset time length; if yes, execute step S10, if not, return to step S8.

[0145] Step S10, gate the first sensor, and obtain the first voltage value detected by the first voltage detection module.

[0146] Step S11, gate the second sensor, and obtain the second voltage value detected by the first voltage detection module.

[0147] Step S12, send the first voltage value, the second voltage value, the third voltage value and the fourth voltage value to the server through the electronic device.

[0148] In this example, the server will calculate the blood glucose concentration value according to the first voltage value, the second voltage value, the third voltage value and the fourth voltage value, and obtain the corresponding blood glucose concentration value. The server calculates the blood glucose concentration value in the same way as the control module, which will not be repeated here.

[0149] Step S13, receive the blood glucose concentration value returned by the server based on the first voltage value, the second voltage value, the third voltage value and the fourth voltage value.

[0150] The present application can be a system, a method and / or a computer program product. The computer program product can include a computer readable storage medium having computer readable program instructions loaded thereon for causing a processor to implement various aspects of the present application.

[0151] Computer readable storage media can be tangible storage media which can retain and store instructions for use by an instruction execution device. Computer readable storage media can be, for example, but is not limited to, an electronic storage device, a magnetic storage device, an optical storage device, an electromagnetic storage device, a semiconductor storage device, or any suitable combination of the foregoing. More specific examples (a non-exhaustive list) of computer readable storage media include the following: a portable computer diskette, a hard disk, a random access memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or Flash memory), a static random access memory (SRAM), a portable compact disc read-only memory (CD-ROM), a digital versatile disk (DVD), a memory stick, a floppy disk, a mechanically encoded device such as punch-cards or raised structures in a groove having instructions recorded thereon, and any suitable combination of the foregoing. A computer readable storage medium, as used herein, is not to be construed as being transitory signals per se, such as radio waves or other freely propagating electromagnetic waves, electromagnetic waves propagating through a waveguide or other transmission media (e.g., light pulses passing through a fiber-optic cable), or electrical signals transmitted through a wire.

[0152] Computer readable program instructions described herein can be downloaded to respective computing / processing devices from a computer readable storage medium or to an external computer or external storage device via a network, for example, the Internet, a local area network, a wide area network and / or a wireless network. The network can comprise copper transmission cables, optical transmission fibers, wireless transmission, routers, firewalls, switches, gateway computers and / or edge servers. A network adapter card or network interface in each computing / processing device receives computer readable program instructions from the network and forwards the computer readable program instructions for storage in a computer readable storage medium within the respective computing / processing device.

[0153] Computer readable program instructions for carrying out operations of the present application can be assembler instructions, instruction-set-architecture (ISA) instructions, machine instructions, machine dependent instructions, microcode, firmware instructions, state-setting data, or either source code or object code written in any combination of one or more programming languages, including an object oriented programming language such as Smalltalk, C++ or the like and conventional procedural programming languages, such as the "C" programming language or similar programming languages. The computer readable program instructions can execute entirely on the user's computer, partly on the user's computer, as a stand-alone software package, partly on the user's computer and partly on a remote computer or entirely on the remote computer or server. In the latter scenario, the remote computer can be connected to the user's computer through any type of network, including a local area network (LAN) or a wide area network (WAN), or the connection can be made to an external computer (for example, through the Internet using an Internet Service Provider). In some embodiments, electronic circuitry including, for example, programmable logic circuitry, field-programmable gate array (FPGA), or programmable logic array (PLA) can execute the computer readable program instructions by utilizing state information of the computer readable program instructions to personalize the electronic circuitry, in order to perform aspects of the present application.

[0154] The computer readable program instructions can also be loaded onto a computer, other programmable data processing apparatus, or other device to cause a series of operational steps to be performed on the computer, other programmable apparatus or other device to produce a computer implemented process such that the instructions which execute on the computer or other programmable apparatus provide processes for implementing the functions / acts specified in the flowchart and / or block diagram block or blocks.

[0155] These computer readable program instructions can be provided to a processor of a general purpose computer, special purpose computer, or other programmable data processing apparatus to produce a machine, such that the instructions, which execute via the processor of the computer or other programmable data processing apparatus, create means for implementing the functions / acts specified in the flowchart and / or block diagram block or blocks. These computer readable program instructions can also be stored in a computer readable storage medium that can include random access memory (RAM), read only memory (ROM), electrically erasable programmable read only memory (EEPROM), flash memory or nonvolatile memory, or a suitable combination of the different types of computer readable storage media. The computer readable program instructions can also be downloaded to a computer, other programmable data processing apparatus, or other device from a computer readable storage medium or to an external computer or external storage device via a data signal that can be transmitted for example via a wired medium or a wireless medium such as the Internet or Wireless Application Protocol (WAP) signaling.

[0156] The computer readable program instructions can also be loaded onto a computer, other programmable data processing apparatus, or other device to cause a series of operational steps to be performed on the computer, other programmable data processing apparatus or other device to produce a computer implemented process such that the instructions which execute on the computer, other programmable data processing apparatus, or other device implement the functions / acts specified in the flowchart and / or block diagram block or blocks.

[0157] The computer readable program instructions can also be loaded onto a computer, other programmable data processing apparatus, or other device to cause a series of operational steps to be performed on the computer, other programmable data processing apparatus or other device to produce a computer implemented process such that the instructions which execute on the computer, other programmable data processing apparatus, or other device implement the functions / acts specified in the flowchart and / or block diagram block or blocks.

[0158] Embodiments of the present application have been described above, and the description is intended to be illustrative, and not restrictive, of the disclosed embodiments. Many modifications and variations of the described embodiments are possible, and all such modifications and variations are intended to be within the scope of the described embodiments. The description used herein is intended to best explain the principles of the embodiments, the practical application, and the best mode of the present application, to make this disclosure understood in the art. The scope of the present application is defined by the appended claims.

Claims

1. A blood glucose monitoring device, characterized by, The device comprises a tissue fluid gathering module, a first sensor, a second sensor, a first voltage detection module, a second voltage detection module, a reference electrode, a control module, wherein: The tissue fluid gathering module is connected between the control module and the first sensor, and is configured to gather subcutaneous tissue fluid under the control of the control module; The first sensor is configured to generate a first current by electrochemical reaction with the skin surface of the subcutaneous tissue fluid gathered by the tissue fluid gathering module; The second sensor is connected with the reference electrode, and is configured to generate a second current by electrochemical reaction with the skin surface to which the reference electrode is attached; The first voltage detection module is connected between the first sensor and the control module, and is configured to monitor a first voltage value of the first current and send the first voltage value to the control module; The second voltage detection module is connected between the second sensor and the control module, and is configured to monitor a second voltage value of the second current and send the second voltage value to the control module; The control module is configured to obtain a blood glucose concentration value according to the first voltage value and the second voltage value. The first voltage detection module and the second voltage detection module are the same, and the device further comprises a gating module, the first voltage detection module is connected between the control module and the gating module, and the control terminal of the control module is connected with the gating module, so as to control the gating module to select the first sensor and the second sensor at different time points. The tissue fluid gathering module comprises a booster circuit and a gathering electrode, the booster circuit is connected between the control module and the first end of the gathering electrode, the second end of the gathering electrode is connected with the first sensor, and the gathering electrode gathers subcutaneous tissue fluid under the boosting action of the booster circuit.

2. The apparatus of claim 1, wherein, The device further comprises a communication module connected with the control module, and the communication module is configured to send the first voltage value and the second voltage value to a target device under the control of the control module.

3. The apparatus of claim 1, wherein, The control module is configured to receive a blood glucose concentration value returned by the target device with respect to the first voltage value and the second voltage value through the communication module. The method is applied to the device of any one of claims 1 to 3, and the method comprises:

4. A blood glucose monitoring method characterized by, In the case of controlling the tissue fluid gathering module to gather subcutaneous tissue fluid, obtaining a first voltage value detected by the first voltage detection module and a second voltage value detected by the second voltage detection module; According to the first voltage value and the second voltage value, determining a blood glucose concentration value. The method further comprises:

5. The method of claim 4, wherein, In the case of not controlling the tissue fluid gathering module to gather subcutaneous tissue fluid, obtaining a third voltage value detected by the first voltage detection module and a fourth voltage value detected by the second voltage detection module; According to the first voltage value and the second voltage value, determining a blood glucose concentration value, comprising: According to the first voltage value, the second voltage value, the third voltage value and the fourth voltage value, determining a blood glucose concentration value. ​ 6. The method of claim 5, wherein, The method further comprises: receiving a sampling parameter; wherein the sampling parameter comprises a sampling start time and a sampling time interval; in response to the sampling parameter, determining a plurality of sampling times; in a case where the sampling start time is reached, controlling the tissue fluid aggregation module to not aggregate subcutaneous tissue fluid; in a case where a sampling time other than the sampling start time is reached, controlling the tissue fluid aggregation module to aggregate subcutaneous tissue fluid.

7. The method of claim 5, wherein, After the step of controlling the tissue fluid aggregation module to aggregate subcutaneous tissue fluid, the method further comprises: in a case where a control duration is greater than or equal to a preset duration, performing the steps of acquiring the first voltage value monitored by the first voltage detection module and the second voltage value monitored by the second voltage detection module. The first voltage detection module and the second voltage detection module are the same, and the device further comprises a gating module, the first voltage detection module is connected between the control module and the gating module, the control module is connected with the control end of the gating module, and the gating module is used to control the gating module to select the first sensor and the second sensor at different times, and the method further comprises: in a case where any sampling time of the plurality of sampling times is reached, controlling the gating module to sequentially select the first sensor and the second sensor. The method further comprises:

8. The method of claim 4, wherein, determining a first current value according to the first voltage value and the third voltage value; determining a second current value according to the second voltage value and the fourth voltage value; 9. The method of claim 7, wherein, determining a target current value according to the first current value and the second current value; wherein the target current value is a current difference value between the first current value and the second current value; determining a blood glucose concentration value corresponding to the target current value according to a preset mapping relationship and the target current value; wherein the preset mapping relationship is a corresponding relationship between current and blood glucose concentration. The method further comprises: receiving a sampling parameter; wherein the sampling parameter comprises a sampling start time and a sampling time interval; in response to the sampling parameter, determining a plurality of sampling times; in a case where the sampling start time is reached, controlling the tissue fluid aggregation module to not aggregate subcutaneous tissue fluid; in a case where a sampling time other than the sampling start time is reached, controlling the tissue fluid aggregation module to aggregate subcutaneous tissue fluid. After the step of controlling the tissue fluid aggregation module to aggregate subcutaneous tissue fluid, the method further comprises: in a case where a control duration is greater than or equal to a preset duration, performing the steps of acquiring the first voltage value monitored by the first voltage detection module and the second voltage value monitored by the second voltage detection module. The first voltage detection module and the second voltage detection module are the same, and the device further comprises a gating module, the first voltage detection module is connected between the control module and the gating module, the control module is connected with the control end of the gating module, and the gating module is used to control the gating module to select the first sensor and the second sensor at different times, and the method further comprises: in a case where any sampling time of the plurality of sampling times is reached, controlling the gating module to sequentially select the first sensor and the second sensor.

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