A preparation process of orange peel soup soft capsule

Abstract

A preparation process of tangerine peel soup soft capsules specifically includes the steps of preparing soup, preparing raw materials and forming soft capsules, wherein in the step of preparing raw materials, volatile components (volatile oils) in the soup can be extracted by steam distillation, and the contents of the soft capsules can be obtained by adding vegetable oil for dissolution treatment, and water-soluble components (solid powders) of the soup can be extracted by decoction, and the core of the inner capsule can be obtained by adding vegetable oil for dispersion treatment, thereby reducing the possibility of effective volatile components being lost during the decoction process, realizing the recovery and reuse of volatile components, and different from the method of directly taking tangerine peel soup soup orally, the capsule-in-capsule technology is used to encapsulate drug components of different properties of tangerine peel soup in the soft capsule, which can maintain the water-soluble components and fat-soluble volatile oils to release in the same position, synchronously and in the same direction, further ensuring the efficacy of tangerine peel soup.

Description

Technical Field

[0001] The invention relates to the technical field of soft capsule processing, in particular to a preparation process of orange peel soup soft capsule. Background Art

[0002] As a prescription medicine, tangerine peel soup is mainly used for the treatment of lung and related diseases. When using the current tangerine peel soup medicine, it is usually necessary to first decoct specific medicinal materials, and then take the decoction directly to drink after the decoction is completed. This way of use, on the one hand, due to the effective volatile components in the tangerine peel soup preparation, if it is decocted for a long time, it is easy to cause the effective components to evaporate and lose, reducing the efficacy of the tangerine peel soup. If the boiling time is too short, it is difficult to extract the effective components in the medicinal materials through decoction, and the tangerine peel soup still cannot achieve the expected efficacy. On the other hand, this direct drinking method causes the different properties of the ingredients in the tangerine peel soup to enter the digestive system in a mixed state, and because the concentration of the effective ingredients in the decoction is low, the various properties of the ingredients in the tangerine peel soup cannot be guaranteed to release the drug in the same direction at the same time, thereby reducing the effect of taking the tangerine peel soup Chinese medicine compound preparation. Summary of the invention

[0003] In order to solve the technical problems existing in the above-mentioned background technology, the present invention provides a preparation process of orange peel soup soft capsules.

[0004] The technical solution of the present invention is as follows:

[0005] The present invention provides a preparation process of tangerine peel soup soft capsules, which specifically comprises the following steps:

[0006] S1. Preparation of soup;

[0007] Mix tangerine peel, ginger and water and boil for a preset time to make a soup;

[0008] S2. Preparation of raw materials;

[0009] Continue to decoct, and use the double extraction method to prepare the contents and capsule core during the decoction process, which specifically includes the following two operations:

[0010] A. Preparation of contents;

[0011] AS2.1, extract the volatile oil from the soup by steam distillation;

[0012] AS2.2, adding vegetable oil to volatile oil, dissolving the volatile oil in the vegetable oil, and using it as the content of the soft capsule;

[0013] B. Preparation of capsule core;

[0014] BS2.1. Use the decoction method to extract the water extract of the decoction during or after the decoction;

[0015] BS2.2, refining the water extract to obtain a refined liquid;

[0016] BS2.3, concentrate the refined liquid under reduced pressure to obtain an extract;

[0017] BS2.4, spray drying the extract to obtain a solid powder;

[0018] BS2.5, add vegetable oil into the solid powder and disperse it to obtain a suspension, which is used as the core material of the inner capsule;

[0019] S3, soft capsule molding;

[0020] The soft capsule is finally pressed and molded by a soft capsule machine through one-time molding or two-time molding;

[0021] Among them, the steps of secondary molding are:

[0022] aS3.1, preparing a small inner capsule containing a suspension by a first soft capsule machine;

[0023] aS3.2, using a second soft capsule machine to prepare a capsule-in-capsule type soft capsule containing contents and an inner capsule;

[0024] The steps of one-step molding are:

[0025] The capsule-in-capsule type soft capsule containing contents and inner capsule is directly prepared by the third soft capsule machine.

[0026] The above-mentioned tangerine peel soup soft capsule preparation process can complete the extraction and collection of volatile oil in the soup during the decoction process, and dissolve the volatile oil components in vegetable oil as the outer capsule content, and at the same time encapsulate the water-soluble components in the inner capsule of the soft capsule as the capsule core, thereby reducing the possibility of effective volatile components being lost during the decoction process, and realizing the reuse of volatile components. Moreover, different from the method of directly orally taking the soup, the soft capsule of the present invention utilizes the capsule-in-capsule technology to encapsulate the medicinal components of different properties of the tangerine peel soup in the soft capsule, which can maintain the water-soluble components and the fat-soluble volatile oil in the same position, synchronization, and same direction of drug release, and further ensure the efficacy of the tangerine peel soup.

[0027] In the preparation process of the orange peel soup soft capsule as described above, in order to ensure the efficacy of the extracted soup and the utilization rate of the medicinal materials (tangerine peel and ginger), in step S1, the ratio of tangerine peel, ginger and water is 5:2:25.

[0028] As a preferred implementation, in step S1, the preset time is at least 30 minutes, so as to ensure that the effective ingredients in the medicinal materials can be fully decocted into the soup.

[0029] As further preferred, in step S1, the preset time is 50-70 minutes, which can effectively prevent excessive loss of effective volatile oil components in the soup while ensuring sufficient decoction of the medicinal materials.

[0030] More preferably, in step S1, the decoction temperature is 80-90°C, which ensures that the medicinal materials have sufficient decoction temperature to facilitate the precipitation of effective ingredients in the medicinal materials, while preventing overheating from accelerating excessive volatilization of effective volatile oil components in the soup, thereby ensuring the efficacy of the soup.

[0031] In the above-mentioned preparation process of the orange peel soup soft capsule, in step S2, the ratio of volatile oil to vegetable oil is 1:5-1:3, which ensures that the volatile oil can be fully dissolved in the vegetable oil while ensuring the efficacy of the content.

[0032] As a preferred embodiment, in step S2, the ratio of volatile oil to vegetable oil is 1:4.

[0033] In the above-mentioned preparation process of the orange peel soup soft capsule, in step BS2.2, the specific refining treatment steps are:

[0034] BS2.2.1. Heat and concentrate the water extract to 1:1.3-1:1.7 (ml:g) to ensure the concentration of the final refined solution;

[0035] BS2.2.2. Cool the concentrated water extract to room temperature;

[0036] BS2.2.3. Slowly add ethanol to the water extract while stirring;

[0037] BS2.2.4. Store the aqueous extract with ethanol in a sealed container for 24-48 hours;

[0038] BS2.2.5. Filter and recover the ethanol in the filtrate to obtain a refined liquid.

[0039] In the preparation process of the orange peel soup soft capsule as described above, in step BS2.5, the ratio of solid powder to vegetable oil is 1:7-1:4, which ensures that the solid powder can be fully dispersed in the vegetable oil while ensuring the efficacy of the capsule core.

[0040] As a preferred embodiment, in step BS2.5, the ratio of solid powder to vegetable oil is 1:5.

[0041] The beneficial effects of the present invention are as follows: the present invention is a preparation process of a tangerine peel soup soft capsule, which can complete the extraction and collection of volatile oil in the soup during the decoction process, and dissolve the volatile oil component in vegetable oil as the outer capsule content, and at the same time encapsulate the water-soluble component in the inner capsule of the soft capsule as the capsule core, thereby reducing the possibility of effective volatile components being lost during the decoction process, realizing the reuse of volatile components, and different from the method of directly taking the soup orally, the soft capsule of the present invention utilizes the capsule-in-capsule technology to encapsulate the medicinal components of different properties of the tangerine peel soup in the soft capsule, which can maintain the water-soluble component and the fat-soluble volatile oil to release in the same position, synchronously and in the same direction, and further ensure the efficacy of the tangerine peel soup. BRIEF DESCRIPTION OF THE DRAWINGS

[0042] By reading the detailed description of the preferred embodiment below, the scheme and advantages of the present application will become clear to those skilled in the art. The accompanying drawings are only for the purpose of illustrating the preferred embodiment and are not to be considered as limiting the present invention.

[0043] In the attached picture:

[0044] Figure 1 It is a flow chart of the preparation process of the orange peel soup soft capsule in the embodiment;

[0045] Figure 2 Schematic diagram of the preparation steps of the raw materials in the embodiment;

[0046] Figure 3 Schematic diagram of the molding steps of the soft capsule in the embodiment. DETAILED DESCRIPTION

[0047] Exemplary embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings.

[0048] Example

[0049] This embodiment provides a preparation process of orange peel soup soft capsules, see Figure 1 , including the preparation of soup, preparation of raw materials and molding steps of soft capsules. The specific preparation process (steps) of soft capsules are discussed in detail below with reference to the accompanying drawings:

[0050] S1. Preparation of soup;

[0051] Mix tangerine peel, ginger and water and boil for a preset time to make a soup. Specifically:

[0052] S1.1. Take a preset ratio of tangerine peel, ginger and cold water, wherein the tangerine peel is washed in advance and the ginger is peeled in advance;

[0053] In order to ensure the utilization rate of medicinal materials (tangerine peel and ginger), the ratio of tangerine peel, ginger and cold water is preferably 5:2:25;

[0054] S1.2. Place tangerine peel, ginger and cold water in a decoction container, and boil for a preset time when the preset temperature is reached;

[0055] As a preferred embodiment, the preset time is at least 30 minutes, so as to ensure that the effective ingredients in the medicinal materials can be fully decocted into the soup;

[0056] As a preferred embodiment, the preset temperature (decoction temperature) is 80-90°C, which ensures that the medicinal materials have sufficient decoction temperature to facilitate the precipitation of effective ingredients in the medicinal materials, and prevents overheating from accelerating the excessive volatilization of effective volatile oil components in the soup, thereby ensuring the efficacy of the soup;

[0057] S2. Preparation of raw materials;

[0058] Combination Figure 2 , continue to decoct, and use the double extraction method to prepare the contents and capsule core during the decoction process, which specifically includes the following two operations:

[0059] A. Preparation of contents;

[0060] AS2.1, extract the volatile oil from the soup by steam distillation;

[0061] AS2.2, adding vegetable oil to the extracted and collected volatile oil, stirring to dissolve the volatile oil in the vegetable oil, and using the volatile oil as the content of the soft capsule;

[0062] As a preferred embodiment, the ratio of volatile oil to vegetable oil is 1:5-1:3, which ensures that the volatile oil can be fully dissolved in the vegetable oil while ensuring the efficacy of the content;

[0063] B. Preparation of capsule core;

[0064] BS2.1. Use the decoction method (continuous decoction) to extract the water extract of the decoction during or after the decoction is completed;

[0065] BS2.2, refining the water extract to obtain a refined liquid;

[0066] The specific refining steps are:

[0067] BS2.2.1. Heat and concentrate the water extract to 1:1.3-1:1.7 (ml:g) to ensure the concentration of the final refined solution;

[0068] BS2.2.2. Cool the concentrated water extract to room temperature;

[0069] BS2.2.3. Slowly add ethanol to the water extract while stirring;

[0070] BS2.2.4. Store the aqueous extract with ethanol in a sealed container for 24-48 hours;

[0071] BS2.2.5. Filter and recover the ethanol in the filtrate to obtain a refined liquid.

[0072] BS2.3, concentrate the refined liquid under reduced pressure to obtain an extract;

[0073] BS2.4, spray drying the extract to obtain a solid powder;

[0074] BS2.5, add vegetable oil into the solid powder, stir to disperse the solid powder into the vegetable oil, and prepare a suspension as the core material of the inner capsule;

[0075] As a preferred embodiment, the ratio of solid powder to vegetable oil is 1:7-1:4, which ensures that the solid powder can be fully dispersed in the vegetable oil while ensuring the efficacy of the capsule core;

[0076] S3, soft capsule molding;

[0077] Combination Figure 3 , through the soft capsule machine, and complete the final compression molding of the soft capsule through one-time molding or two-time molding;

[0078] Among them, the steps of secondary molding are:

[0079] aS3.1. A small inner capsule containing a suspension is prepared by a first soft capsule machine. The first soft capsule machine may be a fully automatic soft capsule machine disclosed in the application document with application number CN202320590857.8 in the patent library. The structure thereof will not be described in detail here.

[0080] aS3.2, through the second soft capsule machine, a capsule-in-capsule type soft capsule containing content and inner capsule is prepared, the second soft capsule machine includes a mold for manufacturing a mother-and-child capsule of a soft capsule-in-hard capsule disclosed in the application document with application number CN201820235746.9 in the patent library, the inner capsule can be transferred from the hard capsule roller to the middle extrusion roller, and the final molding of the capsule-in-capsule type soft capsule is achieved by the cooperation of the middle extrusion roller and the soft capsule extrusion roller, and its structure is not specifically described here;

[0081] The steps of one-step molding are:

[0082] Through the third soft capsule machine, capsule-in-capsule type soft capsules containing contents and inner capsules are directly produced. The third soft capsule machine can be a double-blended soft capsule production device disclosed in the application document with application number CN202311071464.7 in the patent library. Its structure is not described in detail here.

[0083] The above-mentioned tangerine peel soup soft capsule preparation process can complete the extraction and collection of volatile oil in the soup during the decoction process, and dissolve the volatile oil components in vegetable oil as the outer capsule content, and at the same time encapsulate the water-soluble components in the inner capsule of the soft capsule as the capsule core, thereby reducing the possibility of effective volatile components being lost during the decoction process, and realizing the reuse of volatile components. Moreover, different from the method of directly orally taking the soup, the soft capsule of the present invention utilizes the capsule-in-capsule technology to encapsulate the medicinal components of different properties of the tangerine peel soup in the soft capsule, which can maintain the water-soluble components and the fat-soluble volatile oil in the same position, synchronization, and same direction of drug release, and further ensure the efficacy of the tangerine peel soup.

[0084] In this embodiment, as a further preferred implementation, in step BS2.5, the ratio of solid powder to vegetable oil is 1:5, and in step S2, the ratio of volatile oil to vegetable oil is 1:4.

[0085] More preferably, in step S1.2, the preset time is preferably 50-70 minutes, which can effectively prevent excessive loss of effective volatile oil components in the soup while ensuring sufficient decoction of the medicinal materials.

Claims

1. A preparation process of orange peel soup soft capsules, characterized in that: The specific steps include: S1. Preparation of soup; Mix tangerine peel, ginger and water and boil for a preset time to make a soup; S2, preparation of raw materials; The double extraction method is used to prepare the contents and the capsule core, which specifically includes the following two operations: A. Preparation of contents; AS2.1, extract the volatile oil from the soup by steam distillation; AS2.2, adding vegetable oil to volatile oil as the content of filling soft capsules; B. Preparation of capsule core; BS2.1, extract the water extract of the decoction by decoction method; BS2.2, refining the water extract to obtain a refined liquid; BS2.3, concentrate the refined liquid under reduced pressure to obtain an extract; BS2.4, spray drying the extract to obtain a solid powder; BS2.5, add vegetable oil into the solid powder and disperse it to obtain a suspension, which is used as the core material of the inner capsule; S3, soft capsule molding; The soft capsule is finally pressed and molded by a soft capsule machine through one-time molding or two-time molding; Among them, the secondary molding steps are: aS3.1, preparing a small inner capsule containing a suspension by a first soft capsule machine; aS3.2, using a second soft capsule machine to prepare a capsule-in-capsule type soft capsule containing contents and an inner capsule; The primary molding steps are: The capsule-in-capsule type soft capsule containing contents and inner capsule is directly prepared by the third soft capsule machine.

2. The preparation process of a tangerine peel soup soft capsule according to claim 1, characterized in that: In step S1, the ratio of tangerine peel, ginger and water is 5:2:

25.

3. The preparation process of a tangerine peel soup soft capsule according to claim 1, characterized in that: In step S1, the preset time is at least 30 minutes.

4. The preparation process of a tangerine peel soup soft capsule according to claim 3, characterized in that: In step S1, the preset time is 50-70 minutes.

5. The preparation process of a tangerine peel soup soft capsule according to claim 1, characterized in that: In step S1, the boiling temperature is 80-90°C.

6. The preparation process of the orange peel soup soft capsule according to claim 1, characterized in that: In step S2, the ratio of volatile oil to vegetable oil is 1:5-1:

3.

7. The preparation process of the orange peel soup soft capsule according to claim 6, characterized in that: In step S2, the ratio of volatile oil to vegetable oil is 1:

4.

8. The preparation process of the orange peel soup soft capsule according to claim 1, characterized in that: In step BS2.2, the specific refining steps are: BS2.2.

1. Heat and concentrate the aqueous extract to 1:1.3-1:1.7 (ml:g); BS2.2.

2. Cool the concentrated water extract to room temperature; BS2.2.

3. Slowly add ethanol to the water extract while stirring; BS2.2.

4. Store the aqueous extract with ethanol in a sealed container for 24-48 hours; BS2.2.

5. Filter and recover the ethanol in the filtrate to obtain a refined liquid.

9. The preparation process of the orange peel soup soft capsule according to claim 1, characterized in that: In step BS2.5, the ratio of solid powder to vegetable oil is 1:7-1:

4.

10. The preparation process of the orange peel soup soft capsule according to claim 9, characterized in that: In step BS2.5, the ratio of solid powder to vegetable oil is 1:5.

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