Gastrointestinal ultrasound contrast agent and use method thereof

Abstract

The invention relates to a gastrointestinal ultrasound contrast agent and a use method thereof. The gastrointestinal ultrasonic contrast agent comprises rice or millet, soybeans, pericarpium citri reticulatae, Chinese yams, coix seeds and cooked endothelium corneum gigeriae galli. Wherein the gastrointestinal ultrasound contrast agent is powdery. According to the contrast agent disclosed by the embodiment of the invention, the influence of individual difference of stomach capacity and gas interference on gastrointestinal ultrasound contrast diagnosis can be reduced, so that the diagnosis effect on gastrointestinal diseases, especially gastrointestinal ulcer diseases, is improved.

Description

Technical Field

[0001] The present invention relates to the field of medical technology, and in particular to a gastrointestinal ultrasound contrast agent and a use method thereof. Background Art

[0002] Gastrointestinal ultrasound angiography is a method that uses contrast agents to fill the gastrointestinal cavity, eliminating the interference of gas and contents in the gastrointestinal cavity with ultrasound, so that the gastrointestinal wall structure and its lesions can be clearly displayed.

[0003] Contrast media (also known as contrast media) are chemicals injected (or taken) into human tissues or organs to enhance the effect of image observation. The density of these products is higher or lower than that of the surrounding tissues, and the contrast formed is used to display images with certain instruments. For example, iodine preparations and barium sulfate are commonly used in X-ray observation.

[0004] At present, there are various types of gastrointestinal ultrasound contrast agents used in China, including cereal-based paste foods, contrast agents prepared from Chinese herbal medicine extracts, and composite microcrystalline cellulose dispersed with room temperature water. Foreign research on gastrointestinal ultrasound contrast agents is also developing continuously, and there are many types of contrast agents to choose from. For example, there are contrast agents based on gas microbubbles, which improve the contrast effect and stability through special shell materials and gas composition design.

[0005] In recent years, gastrointestinal ultrasound contrast imaging has gradually become a widely used examination technology, with technical advantages including safety, non-invasiveness, comprehensive observation, dynamic scanning, and high repeatability. However, there are the following problems with gastrointestinal ultrasound contrast agents: (1) Since the examination properties depend on the contrast agent, the performance of the contrast agent directly affects the observation effect; (2) Due to individual differences, gastric capacity and gas interference vary, and the oral dose of contrast agent affects whether a sufficiently clear and complete image can be obtained to a certain extent; at the same time, the diagnostic accuracy of superficial erosions and ulcers is also affected; (3) The gas interference problem has not been completely solved.

[0006] Therefore, seeking a high-performance gastrointestinal ultrasound contrast agent has become an important issue that needs to be solved urgently. Summary of the invention

[0007] In order to solve at least one of the above technical problems, the present invention provides a gastrointestinal ultrasound contrast agent and a method for using the same.

[0008] As one aspect, the present invention provides a gastrointestinal ultrasound contrast agent, which includes: rice or millet, soybean, tangerine peel, yam, coix seed and cooked chicken gizzard lining; wherein the gastrointestinal ultrasound contrast agent is in powder form.

[0009] In some embodiments of the present invention, the gastrointestinal ultrasound contrast agent comprises the following components in parts by weight:

[0010]

[0011] For example, rice or millet can be 23.8 parts, 25.6 parts, 27.9 parts, 29.1 parts, 31.4 parts, 33.8 parts, etc.; soybeans can be 13.2 parts, 16.6 parts, 19.9 parts, 23.1 parts, 26.4 parts, 27.8 parts, etc.; tangerine peel can be 4.2 parts, 7.6 parts, 9.8 parts, 12.1 parts, 13.4 parts, 15.8 parts, etc.; yam can be 6.2 portions, 8.6 portions, 9.9 portions, 11.1 portions, 14.4 portions, 16.8 portions, 17.1 portions, 18.8 portions, etc.; coix seeds can be 2.2 portions, 5.6 portions, 8.9 portions, 10.1 portions, 13.4 portions, 15.8 portions, 16.1 portions, 17.8 portions, etc.; cooked chicken gizzard lining can be 1.2 portions, 2.6 portions, 4.9 portions, 5.1 portions, 7.4 portions, 8.6 portions, etc.

[0012] In some embodiments of the present invention, the gastrointestinal ultrasound contrast agent comprises the following components in parts by weight:

[0013]

[0014]

[0015] For example, rice or millet can be 28.2 parts, 28.6 parts, 28.9 parts, 29.1 parts, 29.4 parts, 29.8 parts, etc.; soybeans can be 18.2 parts, 18.6 parts, 18.9 parts, 19.1 parts, 19.4 parts, 19.8 parts, etc.; tangerine peel can be 7.2 parts, 7.6 parts, 7.9 parts, 8.1 parts, 8.4 parts, 8.8 parts, etc.; yam can be 8 .2 parts, 8.6 parts, 8.9 parts, 9.1 parts, 9.4 parts, 9.8 parts, 9.1 parts, 9.8 parts, etc.; coix seeds can be 7.2 parts, 8.6 parts, 8.9 parts, 9.1 parts, 9.4 parts, 9.8 parts, 10.1 parts, 10.4 parts, 10.8 parts, etc.; cooked chicken gizzard lining can be 3.2 parts, 3.6 parts, 3.9 parts, 4.1 parts, 4.4 parts, 4.8 parts, etc.

[0016] As another aspect, the present invention provides a method for using the above-mentioned gastrointestinal ultrasound contrast agent, which comprises: brewing rice or millet, soybeans, tangerine peel, yam, coix seed and cooked chicken gizzard lining in boiling water to obtain a gastrointestinal ultrasound contrast agent paste.

[0017] In some embodiments of the present invention, the ratio of the mass of the gastrointestinal ultrasound contrast agent to the volume of boiling water is 1g:(10-14)mL, for example, it can be 1g:10.2mL, 1g:10.6mL, 1g:11mL, 1g:11.8mL, 1g:12.6mL, 1g:13.2mL, 1g:13.9mL, etc.; preferably, 1g:10mL.

[0018] The technical solution provided by the embodiment of the present invention has the following advantages:

[0019] The components of the gastrointestinal ultrasound contrast agent of the embodiment of the present invention are all pure food raw materials and have no toxic side effects.

[0020] The gastrointestinal ultrasound contrast agent of the embodiment of the present invention improves the quality of the overall gastrointestinal ultrasound contrast image by selecting the components of the contrast agent and regulating the proportion of the components.

[0021] The gastrointestinal ultrasound contrast agent of the embodiment of the present invention can effectively reduce gas in the gastrointestinal tract through the cooked chicken gizzard lining component in the gastrointestinal ultrasound contrast agent, reduce the impact of gas interference on gastrointestinal ultrasound contrast diagnosis, and improve the quality of gastrointestinal ultrasound contrast images, especially for gastrointestinal ulcer diseases.

[0022] The components of the gastrointestinal ultrasound contrast agent of the embodiment of the present invention are safe, all of which are beneficial to the human body and are inexpensive, thereby reducing the economic burden on patients and minimizing or even avoiding physical discomfort in patients.

[0023] The gastrointestinal ultrasound contrast agent of the embodiment of the present invention can also reduce the influence of individual differences in stomach capacity on gastrointestinal ultrasound contrast diagnosis by increasing different boiling water ratios, thereby improving the diagnostic effect of gastrointestinal diseases, especially gastrointestinal ulcer diseases. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments consistent with the invention and, together with the description, serve to explain the principles of the invention.

[0025] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, for ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative labor.

[0026] Figure 1 Ultrasound image of gastric ulcer in patients taking the gastrointestinal ultrasound contrast agent prepared in Example 1 of the present invention;

[0027] Figure 2Ultrasound image of gastric ulcer in patients taking the gastrointestinal ultrasound contrast agent prepared in Example 1 of the present invention;

[0028] Figure 3 Ultrasound image of a gastric ulcer after taking the gastrointestinal ultrasound contrast agent solution prepared in Example 1 of the present invention for 10 minutes and then taking warm water;

[0029] Figure 4 The ultrasound image of a patient taking the gastrointestinal ultrasound contrast agent prepared in Example 2 of the present invention;

[0030] Figure 5 This is an ultrasound image of a patient taking the gastrointestinal ultrasound contrast agent prepared in Comparative Example 1 of the present invention. DETAILED DESCRIPTION

[0031] In order to more clearly understand the above-mentioned objectives, features and advantages of the present invention, the scheme of the present invention will be further described below. It should be noted that the embodiments of the present invention and the features in the embodiments can be combined with each other without conflict.

[0032] In the following description, many specific details are set forth to facilitate a full understanding of the present invention, but the present invention may also be implemented in other ways different from those described herein; it is obvious that the embodiments in the specification are only part of the embodiments of the present invention, rather than all of the embodiments.

[0033] Example 1

[0034] (1) Preparation of gastrointestinal ultrasound contrast agent

[0035] Weigh the following components of gastrointestinal ultrasound contrast agent:

[0036]

[0037] Weighed rice, soybean, tangerine peel, yam, coix seed and cooked chicken gizzard lining are ground into powder, mixed evenly, and a dry preparation of gastrointestinal ultrasound contrast agent is obtained.

[0038] (2) Application of gastrointestinal ultrasound contrast agents in assisting the visualization of gastric ulcers

[0039] 50 g of the dry contrast agent prepared in Example 1 was prepared with 500 mL of boiled water to prepare 500 mL of echogenic gastrointestinal ultrasound contrast agent solution, which was taken orally after being stirred evenly and then subjected to ultrasound testing. The test results were as follows: Figure 1 and Figure 2 As shown. Among them, Figure 1 The "a" in the figure indicates the possibility of a shallow ulcer on the posterior wall of the stomach; Figure 2 The "b" in the figure indicates the possibility of anterior gastric wall ulcer; the "c" in the figure indicates the possibility of anterior gastric wall ulcer.

[0040] according to Figure 1 and Figure 2 The data analysis in can draw the following conclusions: when the patient can obtain a clear image, the presence of echo contrast agent can show gastric ulcer, but due to the difficulty in distinguishing it from gas echo, it can only indicate the possibility of ulcer.

[0041] 10 minutes after taking the gastrointestinal ultrasound contrast agent solution, take about 200mL to 300mL of warm water (it can be slightly adjusted according to the individual's stomach capacity) as an oral or enema contrast agent, and then perform an ultrasound test; the ultrasound test results are as follows: Figure 3 shown.

[0042] according to Figure 3 The data analysis can draw the following conclusions: First, strong echoes are observed using echogenic contrast agents, and when it is uncertain whether there is gas attached to the wall, non-echoic contrast agents (warm water) are used. On the one hand, the gas can be distinguished (the gas will shift), and on the other hand, the contrast and clarity of the strong echoes at the ulcer and the gastric wall layers can be enhanced, thereby making the diagnosis of gastric ulcer clearer.

[0043] Example 2

[0044] (1) Preparation of gastrointestinal ultrasound contrast agent

[0045] Weigh the following components of gastrointestinal ultrasound contrast agent:

[0046]

[0047] Weighed rice, soybean, tangerine peel, yam, coix seed and cooked chicken gizzard lining are ground into powder, mixed evenly, and a dry preparation of gastrointestinal ultrasound contrast agent is obtained.

[0048] (2) Ultrasonic testing

[0049] 50 g of the dry contrast agent prepared in step (1) was mixed with 500 mL of boiled water to prepare 500 mL of gastrointestinal ultrasound contrast agent solution, which was taken orally after being stirred evenly. Ultrasound testing was performed, and the test results were as follows: Figure 4 shown.

[0050] according to Figure 4 The data analysis in can draw the following conclusion: when using gastrointestinal ultrasound contrast agent added with cooked chicken gizzard lining, the gas echo in the anterior wall of the stomach disappears.

[0051] Comparative Example 1

[0052] (1) Preparation of gastrointestinal ultrasound contrast agent

[0053] Weigh the following components of gastrointestinal ultrasound contrast agent:

[0054]

[0055] The weighed rice, soybean, tangerine peel, yam and coix seed are ground into powder, and mixed evenly to obtain a dry preparation of gastrointestinal ultrasound contrast agent.

[0056] (2) Ultrasonic testing

[0057] 50 g of the dry contrast agent prepared in step (1) was mixed with 500 mL of boiled water to prepare 500 mL of gastrointestinal ultrasound contrast agent solution, which was taken orally after being stirred evenly. Ultrasound testing was performed, and the test results were as follows: Figure 5 shown.

[0058] according to Figure 5 The data analysis in the paper can draw the following conclusions: When using gastrointestinal ultrasound contrast agent without adding cooked chicken gizzard lining, the anterior wall of the stomach can be seen as follows: Figure 5 The gas echo is shown by the arrow.

[0059] In summary, the gastrointestinal ultrasound contrast agent provided by the embodiment of the present invention effectively eliminates gas in the gastrointestinal tract through the cooked chicken gizzard lining, thereby improving the imaging effect (according to Figure 4 and Figure 5 The conclusion obtained by the data analysis) is to achieve the ultrasound imaging effect of echogenic and echoless double contrast agents synergistically enhancing and differential diagnosis (according to Figure 1 to Figure 3 The conclusion obtained from the data analysis of the clinical practice is of high clinical application value.

[0060] It should be noted that, in this article, relational terms such as "first" and "second" are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, the elements defined by the sentence "comprise a ..." do not exclude the existence of other identical elements in the process, method, article or device including the elements.

[0061] The above description is only a specific embodiment of the present invention, so that those skilled in the art can understand or implement the present invention. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments described herein, but should conform to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A gastrointestinal ultrasound contrast agent, characterized in that: The gastrointestinal ultrasound contrast agent includes: rice or millet, soybean, tangerine peel, yam, coix seed and cooked chicken gizzard lining; Wherein, the gastrointestinal ultrasound contrast agent is in powder form.

2. The gastrointestinal ultrasound contrast agent according to claim 1, characterized in that: The gastrointestinal ultrasound contrast agent comprises the following components in parts by mass:

3. The gastrointestinal ultrasound contrast agent according to claim 2, characterized in that: The gastrointestinal ultrasound contrast agent comprises the following components in parts by mass:

4. A method for using the gastrointestinal ultrasound contrast agent according to any one of claims 1 to 3, characterized in that: The method of use includes: The gastrointestinal ultrasound contrast agent paste is prepared by brewing rice or millet, soybean, tangerine peel, yam, coix seed and cooked chicken gizzard lining in boiling water.

5. The method of use according to claim 4, characterized in that: The mass ratio of the gastrointestinal ultrasound contrast agent to the volume ratio of the boiling water is 1 g:(10-14) mL, preferably, 1 g:10 mL.

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