A nutrient tube with lubricating and anti-fouling coatings on its inner and outer surfaces and its continuous preparation method.

Abstract

The present invention relates to the technical field of medical devices, and discloses a nutrient tube with lubricating and anti-fouling coatings on the inner and outer surfaces and a continuous preparation method thereof. The steps include: injecting a solution containing silicon-based MPC into the nutrient tube, and continuously immersing the nutrient tube in the solution containing silicon-based MPC, then continuously extruding the solution in the tube through gear extrusion, and entering a drying oven for drying and curing to obtain a nutrient tube with lubricating and anti-fouling coatings on the inner and outer surfaces. In the present invention, a lubricating and anti-fouling coating is constructed on the inner and outer surfaces of the nutrient tube by a continuous method, thereby reducing the friction between the nutrient tube and tissues such as the nasal cavity wall, and improving the comfort of the patient's use; at the same time, the inner surface of the nutrient tube is endowed with excellent anti-adhesion properties. The method and process are simple, and no special equipment or technical requirements are required, and the coating performance is stable.

Description

Technical Field

[0001] The invention relates to the technical field of medical devices, and in particular to a nutrition tube with lubricating anti-fouling coatings on the inner and outer surfaces and a continuous preparation method thereof. Background Art

[0002] Nutrition tube is a specially designed medical tube in clinical treatment, suitable for patients with unclear consciousness, and the purpose of giving nutrition to patients is achieved by injecting liquid food into the nutrition tube. Its structure mainly includes: the output end is connected to the catheter, the pipe joint, and the input end of the pipe joint can be injected with the injection port of the nutrient solution, and there is a cap for blocking on the injection port, which is usually more than 1 meter long. When the patient uses it, the catheter is inserted through the nostril and directly extends to the small intestine or stomach, and then the liquid food is injected into the injection port, and the liquid food flows along the catheter to the small intestine or stomach to complete the treatment. When the patient uses the nasogastric tube, because the catheter is inserted into the small intestine or stomach, it will rub against the nasal wall, small intestine wall, stomach wall and other tissues, causing the patient to feel strong pain and difficult to tolerate, affecting the patient's compliance with nutrition; in addition, because the liquid food is easy to adhere to the inner wall of the catheter, it often blocks its inner cavity, and warm water pressure flushing or negative pressure suction or special guide wire is required for dredging, thereby increasing the difficulty and cost of nasogastric or enteral feeding for patients, which directly affects the life and health of patients.

[0003] In order to improve the performance of the feeding tube and reduce the side effects during its use, it is necessary to improve the interface of the catheter with greater friction on the outer wall and greater adhesion on the inner wall. At present, interface modification through coating technology has been widely used in medical devices to improve the lubrication performance, blood compatibility, etc. of the device.

[0004] Patent CN215740575U discloses a nutrition tube with a coating on the surface, including a nutrition tube body and a connecting joint. The nutrition tube body is composed of a plastic layer and a lubricating coating. The outer wall of the plastic layer is fixedly provided with a lubricating coating. One end of the nutrition tube body is sleeved and connected with a connecting joint. One side of the connecting joint is fixedly provided with a limit tube. The inner sleeve of the limit tube is provided with a limit spring. One end of the limit tube is inserted and connected with a push column. The push column is sleeved and connected with the limit spring. The bottom end of the connecting joint is threadedly connected with a threaded tube. The nutrition tube body of the utility model is composed of a plastic layer and a lubricating coating. The lubricating coating has a good lubricating effect. When the nutrition tube is used, the nutrition tube body is effectively prevented from damaging the patient. The nutrition tube body is connected to a liquid guide bucket through the connecting joint, which effectively facilitates the input of the nutrient solution and improves the input efficiency of the nutrient solution. The lubrication performance of the outer surface of the nutrition tube is improved by the coating, but there is no specific information on the effect of improving the lubrication performance.

[0005] Patent CN204972314U discloses a super-slip nasogastric tube, but also lacks specific friction parameters. More importantly, these patents currently lack specific preparation processes for coatings, and there are no measures to improve the adhesion performance of the inner cavity.

[0006] Phosphorylcholine coating is a type of zwitterionic compound that mimics biological cell membranes and has excellent biocompatibility. Phosphorylcholine has been used for joint lubrication (Japan's artificial hip joint Aquala), suggesting that phosphorylcholine coating can be used to give nutrition tubes lubrication properties, reduce friction between the tube and tissue during insertion, and reduce the pain of patients. In addition, the high hydrophilicity of phosphorylcholine can form a hydration layer on its surface. These water molecule layers cover the surface of the applied substrate, providing a biological "non-stick" surface, making it possible for it to resist the adhesion of liquid food.

[0007] In addition, this type of coating is mostly accumulated on the surface of the substrate through free radical polymerization reaction, resulting in a thicker coating. Due to the limitations of technology and heating equipment, the steps required for coating preparation are complicated, including the base layer, functional layer, etc. involving multiple stages, the process time is long, and it is not suitable for longer and larger devices. The coating preparation efficiency is low and it is not suitable for engineering transformation. Summary of the invention

[0008] Aiming at the demand for lubricating and anti-fouling coatings for longer nutrient tubes, the present invention provides a method for continuously preparing lubricating and anti-fouling coatings on the inner and outer surfaces of nutrient tubes. High-efficiency lubricating and anti-fouling coatings can be constructed on the inner and outer surfaces of nutrient tubes with longer lengths. The production efficiency is high and the tubes are suitable for engineering transformation.

[0009] To achieve the above object, the technical solution adopted by the present invention is:

[0010] A method for continuously preparing a nutrient tube with a lubricating antifouling coating on the inner and outer surfaces comprises the steps of: injecting a solution containing a silicon-based MPC into the nutrient tube, and continuously immersing the nutrient tube in the solution containing the silicon-based MPC, then continuously extruding the solution in the tube through gear extrusion, and drying and curing the tube in a drying oven to obtain a nutrient tube with a lubricating antifouling coating on the inner and outer surfaces.

[0011] In the present invention, the nutrient tube is pulled into a reaction container by a roller and incubated, so that the surface of the nutrient tube adsorbs MPC containing silicon groups, and the MPC is covalently grafted to the inner and outer surfaces of the fluorescent tube through silicon-oxygen bonds through co-incubation; the coating solution is then discharged before the nutrient tube enters a drying box through gear extrusion, and a stable lubricating and anti-fouling coating is prepared on the surface of the nutrient tube through drying and curing. This method can realize continuous production and is suitable for longer instruments.

[0012] The preparation of the silicon-based MPC comprises the steps of:

[0013] Under the protection of inert gas, 2-methacryloyloxyethyl phosphorylcholine and 3-(trimethoxymethylsilyl)propyl methacrylate are polymerized under the action of an initiator to obtain the siloxy MPC. The polymer not only has the excellent anti-fouling and hydrophilic lubricity of phosphorylcholine, but also has reactive siloxy groups, which makes it possible for it to be covalently grafted to the surface of the device to provide stable hydrophilic lubricity and anti-fouling properties.

[0014] The ratio of phosphorylcholine groups to silane groups in the siloxy MPC is 10:1-3:1, and the ratio of the two affects the anti-fouling / lubricating properties and reactivity of the polymer. A too low concentration of the silane group may result in the inability to covalently graft phosphorylcholine to the surface of the material. This ratio is selected to retain the maximum amount of phosphorylcholine groups while providing a sufficient amount of siloxy groups.

[0015] The initiator comprises one or more of azobisisobutyronitrile, azobisisoheptanenitrile and dimethyl azobisisobutyrate; the mass of the initiator is 0.5-2wt% of the mass of the reaction raw materials.

[0016] The polymerization reaction temperature is 50-80° C., and the reaction time is 15-30 hours.

[0017] The solvent of the solution containing silicon-based MPC includes one or more of ethanol, water, methanol, dichloromethane, n-hexane, and isopropanol; preferably, the solvent is a mixed solution of ethanol and water.

[0018] The material of the nutrition tube is polyurethane.

[0019] The mass volume concentration of the siloxy-MPC in the siloxy-MPC-containing solution is 0.5-10%. Preferably, the mass volume concentration of the siloxy-MPC is 2-10%.

[0020] The nutrient tube stays in the silicon-containing MPC solution for 5-120 minutes at a solution temperature of 40-80° C. The longer the nutrient tube is incubated in the silicon-containing MPC solution, the thicker the coating on its surface becomes. Too thick a coating may reduce its stability, preferably 10-120 minutes.

[0021] The drying and curing time is 10-120 minutes, and the drying temperature is 50-70°C.

[0022] The present invention also provides a nutrition tube having a lubricating antifouling coating on the inner and outer surfaces obtained by the method, wherein the coating has a thickness of 50-200 nm, preferably a thickness of 50-150 nm.

[0023] Compared with the prior art, the present invention has the following beneficial effects:

[0024] (1) In the present invention, a lubricating and anti-fouling coating is constructed on the inner and outer surfaces of the feeding tube through a continuous method, thereby reducing the friction between the feeding tube and tissues such as the nasal wall, thereby improving the comfort of the patient; at the same time, the inner surface of the feeding tube is endowed with excellent anti-adhesion properties to prevent the feeding tube from being blocked, reduce the frequency of device replacement, and alleviate the economic burden on the patient.

[0025] (2) The method of the present invention is simple and does not require special equipment or technical requirements. The coating has stable performance, so that an engineering, economical and stable process can be used to obtain a coating that can improve the lubrication and anti-fouling properties of the surface of the nutrition tube. The coating technology is convenient for directly empowering conventional nutrition tubes, reducing their major clinical adverse reactions and enhancing their market competitiveness. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 The NMR spectrum of the silicon-containing MPC prepared in a specific embodiment.

[0027] Figure 2 The figure is a process schematic diagram of the continuous preparation process of the nutrition tube with lubricating antifouling coating on the inner and outer surfaces in the present invention.

[0028] Figure 3 The stained images of the coated and uncoated nutrient tubes in Example 1 are shown.

[0029] Figure 4 The non-specific protein adsorption diagram of the uncoated and coated nutrition tubes in Example 1. DETAILED DESCRIPTION

[0030] In order to make the purpose, technical scheme and advantages of the present invention clearer, the present invention is further described in detail below in conjunction with embodiment. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention. Those skilled in the art can make modifications or equivalent substitutions based on the understanding of the technical scheme of the present invention without departing from the spirit and scope of the technical scheme of the present invention, and all should be included in the protection scope of the present invention.

[0031] The raw materials used in the following specific embodiments are all purchased from the market. The preparation process of the silane-based MPC includes the following steps:

[0032] Under argon atmosphere, add azobisisobutyronitrile (1wt% of the raw materials), 2-methacryloyloxyethyl phosphorylcholine (MPC) and 33-(trimethoxymethylsilyl) methyl methacrylate (TMSPMA) (wherein the molar ratio of MPC to TMSPMA is 5:1) to the polymerization reaction tube in sequence, add 10ml of ethanol to the reaction tube, and stir to dissolve. Place the reaction tube at 60℃ for 20h. After the reaction is complete, remove the ethanol solvent by rotary evaporation to obtain polymer siloxy MPC. The product was tested by GPC. W(weight average molecular weight) is 113509; nuclear magnetic resonance ( 1 Its structure was detected by H NMR spectroscopy, and its spectrum is as follows Figure 1 As shown, the ratio of phosphorylcholine group to silyl group was calculated using the integrated area ratio on the NMR spectrum, and the molar ratio was 7.8:2.2.

[0033] Example 1

[0034] Continuous preparation equipment such as Figure 2 As shown, step 1, adding MPC containing siloxy groups into a mixed solvent (V 乙醇 :V 水 =95:5) to a mass volume concentration of 3% and poured into a reaction container.

[0035] Step 2, first inject the silicon-containing MPC solution into the nutrition tube (made of polyurethane), start the roller device driven by the motor, make the nutrition tube continuously pass through the silicon-containing MPC solution, set the heating temperature to 50°C, and the elapsed time to 30 minutes.

[0036] Step 3, the nutrient tube is squeezed by the gear to discharge the coating solution before entering the drying oven, and finally enters the drying oven, the temperature is set to 50 ° C, and the curing temperature is 30 minutes, that is, a stable lubricating anti-fouling coating is obtained on the inner and outer surfaces of the nutrient tube. The schematic diagram of the continuous preparation process is shown in Figure 2 shown.

[0037] Example 2

[0038] The only difference between this embodiment and embodiment 1 is that the mass volume concentration of the silicon-containing MPC in step 1 is 6%, and the volume ratio of the mixed solvent is ethanol to water at 99.5:0.5.

[0039] Example 3

[0040] The only difference between this embodiment and embodiment 1 is that the temperature of the reaction container in step 2 is set to 60°C.

[0041] Example 4

[0042] The only difference between this embodiment and embodiment 1 is that the incubation residence time of the nutrient tube in step 2 is 10 minutes.

[0043] Example 5

[0044] The only difference between this embodiment and embodiment 1 is that the incubation residence time of the nutrient tube in step 2 is 120 minutes.

[0045] Example 6

[0046] The only difference between this embodiment and embodiment 1 is that the drying temperature in the drying oven in step 3 is 60°C.

[0047] Example 7

[0048] The only difference between this embodiment and embodiment 1 is that the curing temperature in the drying oven in step 3 is 60 minutes.

[0049] Comparative Example 1 Low concentration

[0050] The only difference between this embodiment and embodiment 1 is that the mass volume concentration of the silicon-containing MPC in step 1 is 0.1%.

[0051] Comparative Example 2 High concentration

[0052] The only difference between this embodiment and embodiment 1 is that the mass volume concentration of the silicon-containing MPC in step 1 is 20%.

[0053] Comparative Example 3 Low Temperature

[0054] The only difference between this embodiment and embodiment 1 is that in step 2, after the nutrition tube enters the reaction container, the reaction temperature is 20° C. and the reaction time is 10 min.

[0055] Comparative Example 4: Short time

[0056] The difference between this embodiment and embodiment 1 is that in step 2, after the nutrition tube enters the reaction container, the reaction temperature is 50° C. and the reaction time is 2 minutes.

[0057] Comparative Example 5: Long time

[0058] The only difference between this embodiment and embodiment 1 is that in step 2, after the nutrition tube enters the reaction container, the reaction temperature is 50° C. and the reaction time is 200 min.

[0059] Comparative Example 6: Curing temperature is too high

[0060] The only difference between this embodiment and embodiment 1 is that in step 3, the nutrition tube enters the drying oven, the temperature is set to 90° C., and the curing temperature is 10 minutes.

[0061] Comparative Example 7: Low curing temperature

[0062] The difference between this embodiment and embodiment 1 is that, in step 3, the nutrition tube enters the drying oven, the temperature is set to 20° C., and the curing temperature is 10 min.

[0063] Sample performance analysis

[0064] (1) Lubrication performance testing of lubricating and anti-fouling coatings for nutrition tubes

[0065] A lubricating coating was prepared on the inner and outer surfaces of the nutrition tube according to the methods in Examples 1-7 and Comparative Examples 1-6. The friction of the outer surface was detected by a friction force detection device. One end of the nutrition tube was hooked on a tensile test sensor. The nutrition tube was clamped between two silicone sheets. The clamping force was set to 3N. The pulling force (N) when the nutrition tube was pulled was recorded. Each sample was tested 8 times (the friction of the surface of the uncoated nutrition tube was tested as a control). The average value was taken to calculate the friction coefficient before and after the coating. The friction coefficient is shown in Table 1.

[0066] Table 1 Surface coating thickness and friction coefficient of the nutrition tube of the embodiment and the comparative example

[0067]

[0068]

[0069] The lubricating coating prepared on the surface of the nutrition tube of the present invention can significantly reduce the friction of its surface (Examples 1-6), making its friction coefficient less than 0.5, thereby reducing the friction between it and tissues such as the nasal wall, and improving the comfort of patients; however, if the reaction time of the nutrition tube in the coating solution is too short, resulting in the prepared coating being too thin (such as the coating thickness of 10.7nm in Comparative Example 4), the improvement of the surface lubrication performance will also be limited (the friction coefficient is greater than 0.7).

[0070] The friction coefficient (0.32) of the coated surface of the nutrient tube in Example 1 (phosphorylcholine concentration of 3%) is greater than the friction coefficient (0.22) of Example 2 (phosphorylcholine concentration of 4%), and both have obvious lubricating properties; while in Comparative Example 1 (phosphorylcholine concentration of 0.1%), the concentration of the phosphorylcholine solution is too low, resulting in too little amount of grafted phosphorylcholine, so that the friction coefficient of the coated surface of the nutrient tube is not significantly reduced; and in Comparative Example 2 (phosphorylcholine concentration of 20%), the concentration of the coating solution is too high, so the coating constructed on the surface of the nutrient tube also has obvious lubricating properties (friction coefficient of 0.25); therefore, the lubricating properties of the coated surface of the nutrient tube are enhanced with the increase of the concentration of the phosphorylcholine solution, and only in the appropriate concentration range (2%-10%) can the prepared coating have obvious lubricating properties while taking into account the thin thickness.

[0071] The friction coefficient (0.38) of the coated nutrient tube surface of Example 4 (incubated for 10 minutes) is greater than the friction coefficient (0.32) of Example 1 (incubated for 30 minutes), and the latter is greater than the friction coefficient (0.21) of Example 5 (incubated for 120 minutes), both of which have obvious lubrication properties; however, since the incubation time of Comparative Example 4 is too short, there is too little grafted phosphorylcholine, so that the reduction of its friction coefficient is not obvious; since the incubation time of Comparative Example 5 is too long, there is excessive irregular accumulation of phosphorylcholine on the surface of the nutrient tube, making the coating uneven, so that the reduction of the friction coefficient of the surface of the prepared coated nutrient tube is not obvious; therefore, the surface lubrication performance of the coated nutrient tube is enhanced as the incubation time in the coating solution increases, and only when it is incubated for an appropriate time (5-120 minutes) can the coating have obvious lubrication properties.

[0072] In Examples 6 (temperature in a drying oven at 60°C for 30 min) and 7 (temperature in a drying oven at 50°C for 60 min), the prepared coated nutrient tubes were dried in a drying oven, and the friction coefficients of the obtained coatings were all less than 0.4, indicating that the coatings had significant lubrication properties. However, in Comparative Example 6 (temperature in a drying oven at 90°C), the nutrient tubes were deformed due to excessively high temperature, and the measured friction coefficient was also relatively large (0.87). In Comparative Example 7 (temperature in a drying oven at 20°C for 30 min), the nutrient tubes were not dried due to excessively low temperature and short time, and thus production requirements could not be met. Therefore, when the coated nutrient tubes are dried in a dryer, they must be dried at a specific temperature (less than 70°C) and time (greater than 10 min) to ensure that the surface of the nutrient tubes is dried without damaging the performance of the nutrient tubes themselves.

[0073] (2) Determination of the thickness of lubricating and antifouling coatings for nutrient tubes

[0074] According to the methods of Examples 1-7 and Comparative Examples 1-7, a coating was prepared on the surface of the nutrition tube, and the coating was measured by an ellipsometer, and three positions of each sample were randomly selected for measurement. The coating thickness is shown in Table 1. From the results, it can be seen that the thickness of the lubricating and anti-fouling coating for the nutrition tube prepared by the present invention is 50-200 nm, and its thickness is thin and uniform.

[0075] The thickness of the surface of the nutrition tube in Example 1 (phosphorylcholine concentration of 3%) (148.2±8.8nm) is less than that in Example 2 (phosphorylcholine concentration of 4%) (191.0±17.0nm), and the thickness is 100-200nm; while in Comparative Example 1 (phosphorylcholine concentration of 0.1%), the concentration of the phosphorylcholine solution is too low, resulting in too little phosphorylcholine grafted, making the coating thickness too low (the coating thickness is not measured), which may be the reason why the friction coefficient is not significantly reduced; while in Comparative Example 2 (phosphorylcholine concentration of 20 %) Due to the high concentration of the coating solution, the coating constructed on the surface of the nutrition tube is too thick (463.0±56.9nm). Although it has obvious lubricating properties (friction coefficient is 0.25), it causes waste of phosphorylcholine and may lead to reduced stability of the coating; therefore, the coating thickness on the surface of the nutrition tube increases with the increase of the concentration of phosphorylcholine solution. Only when the phosphorylcholine concentration is within an appropriate range (2%-10%) can a coating with a thin thickness (50-200nm) and obvious lubricating properties be obtained efficiently and economically.

[0076] The thickness of the coating on the surface of the nutrient tube in Example 4 (incubated for 10 min) (81.4 ± 13.5 nm) is less than that in Example 1 (incubated for 30 min) (148.2 ± 8.8), and the latter is less than that in Example 5 (incubated for 120 min) (196.5 ± 21.9 nm), and the thickness is 50-200 nm; while in Comparative Example 4, due to the short incubation time, the amount of grafted phosphorylcholine is too small, so that its thickness is too thin (10.7 ± 1.3 nm), which is also the friction coefficient. The reason why the number does not decrease significantly; in Comparative Example 5, due to the long incubation time, excessive irregular accumulation of phosphorylcholine on the surface of the nutrient tube resulted in the coating being too thick and uneven (502.3±102.1nm), which also resulted in the friction coefficient of the nutrient tube surface after coating not decreasing significantly; therefore, the coating thickness on the surface of the nutrient tube increases with the extension of the incubation time in the coating solution, and only when the incubation time is appropriate (5-120min) can a uniform and thinner coating be obtained, thereby satisfying the required lubrication performance.

[0077] The coating thickness obtained in Example 6 (temperature 60°C in the drying oven, 30 min) and Example 7 (temperature 50°C in the drying oven, 60 min) is 100-200 nm; while in Comparative Example 6 (temperature 90°C in the drying oven), the nutrient tube is deformed due to the excessively high temperature, but the coating thickness is also relatively thin, but the friction coefficient is relatively large due to the deformation of the nutrient tube; while the coating thickness of Comparative Example 7 (temperature 20°C in the drying oven, 30 min) is 140.1±12.2 nm, which is uniform and thin, but the nutrient tube is not dried due to the low temperature and short time; therefore, when the coated nutrient tube is dried in the dryer, although the temperature and time will not have a significant effect on the coating thickness, it will affect the performance of the substrate itself and the integrity of the process, and it is necessary to dry at a specific temperature (less than 70°C) and time (greater than 10 min) to ensure that a dry, uniform and thin coating is obtained without damaging the performance of the nutrient tube itself.

[0078] (3) Observation of staining of lubricating and antifouling coatings for nutrition tubes

[0079] The coating on the inner and outer surfaces of the nutrient tubes prepared according to Example 1 were dyed with Congo red solution, and photographed and observed. The results are shown in FIG. Figure 3 As can be seen from the dyeing photos, the coatings prepared inside and outside the nutrition tube are uniform and have good integrity, which lays a foundation for achieving external lubrication of the nutrition tube and preventing food residues from adhering to the inner cavity.

[0080] (4) Anti-fouling performance test of lubricating and anti-fouling coatings for nutrition tubes

[0081] According to the method of Example 1, a lubricating and antifouling coating was prepared on a nutrient tube. The antifouling performance of the inner wall was investigated by an anti-nonspecific protein adsorption experiment. The inner wall of the uncoated and coated nutrient tubes was incubated with FITC-labeled albumin solution, respectively, and then washed with PBS for 3 times, dried, and photographed using a fluorescence microscope. The results are shown in FIG. Figure 4 The nutrition tube covalently grafted with phosphorylcholine polymer has excellent anti-fouling properties, which makes it possible to reduce the adhesion of food residues to the inner wall of the nutrition tube, thereby improving the convenience of patients using the nutrition tube (reducing the risk of food clogging the nutrition tube) and even extending its use time, reducing the nutrition cost of patients.

Claims

1. A method for continuously preparing a nutrient tube having a lubricating and anti-fouling coating on the inner and outer surfaces, characterized in that: The method comprises the following steps: injecting a solution containing silicon-based MPC into a nutrient tube, and continuously immersing the nutrient tube in the solution containing silicon-based MPC; then continuously extruding the solution in the tube through gears, and drying and curing the solution in a drying oven to obtain a nutrient tube with lubricating and anti-fouling coatings on the inner and outer surfaces.

2. The method for continuously preparing a nutrient tube having a lubricating and anti-fouling coating on the inner and outer surfaces according to claim 1, characterized in that: The ratio of phosphorylcholine group to silane group in the siloxy MPC is 10:1-3:

1.

3. The method for continuously preparing a nutrient tube having a lubricating and anti-fouling coating on the inner and outer surfaces according to claim 1, characterized in that: The preparation of the silicon-based MPC comprises the steps of: Under the protection of inert gas, 2-methacryloyloxyethyl phosphorylcholine and 3-(trimethoxysilyl)propyl methacrylate are polymerized under the action of an initiator to obtain the siloxy MPC.

4. The method for continuously preparing a nutrient tube having a lubricating and anti-fouling coating on the inner and outer surfaces according to claim 3, characterized in that: The initiator comprises one or more of azobisisobutyronitrile, azobisisoheptanenitrile and dimethyl azobisisobutyrate; the mass of the initiator is 0.5-2wt% of the mass of the reaction raw materials.

5. The method for continuously preparing a nutrient tube having a lubricating and anti-fouling coating on the inner and outer surfaces according to claim 3, characterized in that: The polymerization reaction temperature is 50-80° C., and the reaction time is 15-30 hours.

6. The method for continuously preparing a nutrient tube having a lubricating and antifouling coating on the inner and outer surfaces according to claim 3, characterized in that: The solvent of the solution containing silicon-based MPC includes one or more of ethanol, water, methanol, dichloromethane, n-hexane, and isopropanol; the material of the nutrition tube is polyurethane.

7. The method for continuously preparing a nutrient tube having a lubricating and anti-fouling coating on the inner and outer surfaces according to claim 1, characterized in that: The mass volume concentration of siloxy-MPC in the siloxy-MPC-containing solution is 0.5-10%.

8. The method for continuously preparing a nutrient tube having a lubricating and anti-fouling coating on the inner and outer surfaces according to claim 1, characterized in that: The residence time of the nutrition tube in the solution containing silicon-based MPC is 5-120 minutes, and the solution temperature is 40-80°C.

9. The method for continuously preparing a nutrient tube having a lubricating and anti-fouling coating on the inner and outer surfaces according to claim 1, characterized in that: The drying and curing time is 10-120 minutes, and the drying temperature is 50-70°C.

10. A nutrient tube having a lubricating and antifouling coating on the inner and outer surfaces, obtained by the method according to any one of claims 1 to 9.

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