Selector valve

Abstract

The invention relates to a selector valve, comprising: a stator and a rotor relatively rotatable about a rotation axis, the stator and the rotor respectively having a first surface and a second surface opposite to each other and in motive seal; the first surface is provided with a first access hole, a second access hole, a first stator radial groove, a second stator radial groove and a plurality of pairs of component connecting holes, and the component connecting holes comprise a first component connecting hole and a second component connecting hole; the second surface is provided with a rotor internal flow channel inlet, a rotor internal flow channel outlet, a rotor annular groove and a first rotor radial groove; when the rotor rotates relative to the stator, the first stator radial groove and the second stator radial groove can be communicated with the rotor internal flow channel outlet and the first rotor radial groove respectively. According to the scheme, the problems that an existing chromatography system is complex in structure and operation can be solved, all runners in the selector valve can be flushed, and the situation that the accuracy of follow-up analysis is affected due to internal residues of the selector valve is avoided.

Description

Technical Field

[0001] The present invention relates to the fields of protein purification, nucleic acid synthesis, liquid chromatography, and the like, and in particular to a selection valve for components such as a synthesis column or a chromatography column. Background Art

[0002] In the fields of protein purification, nucleic acid synthesis, liquid chromatography, etc., columns (such as synthesis columns or chromatography columns) are the main devices used to purify, synthesize or differentiate analytes. During the experiment, the switching of the selector valve (column position valve) is used to achieve the process combination of the liquid path passing through the column in the forward direction, passing through the column in the reverse direction or not passing through the column, so as to achieve the purpose of purifying, synthesizing or differentiating the analyte.

[0003] In order to meet more complex process requirements, the chromatography system can include multiple columns. At the same time, the coordinated action of multiple selector valves can be used to switch the flow path to achieve the combined operation of multiple columns, so that the liquid flow can pass through each column in a set order, or each column can work separately to purify, synthesize or differentiate different substances. It can be seen that in a complex chromatography system, the large number of selector valves not only makes the chromatography system structure more complicated, but also increases the complexity of operation. Summary of the invention

[0004] The embodiments of the present application at least provide a selection valve, which can improve the problems of complex structure and operation of existing chromatography systems, and can flush all flow channels inside the selection valve to avoid the selection valve affecting the accuracy of subsequent analysis due to internal residues.

[0005] The embodiment of the present application provides a selection valve, comprising: a stator and a rotor capable of relatively rotating around a rotation axis, wherein the stator and the rotor respectively have a first surface and a second surface facing each other and in dynamic sealing;

[0006] The first surface is provided with a first inlet and outlet hole, a second inlet and outlet hole, a first stator radial slot, a second stator radial slot and a plurality of pairs of component connection holes, the first stator radial slot is connected with the second inlet and outlet hole, the first inlet and outlet hole is located at the rotation axis, the second stator radial slot and the first stator radial slot are symmetrically arranged with respect to the first inlet and outlet hole, each pair of the component connection holes comprises a first component connection hole and a second component connection hole, respectively, and the first component connection hole and the second component connection hole are symmetrically arranged with respect to the first inlet and outlet hole;

[0007] The second surface is provided with a rotor internal flow channel inlet, a rotor internal flow channel outlet, a rotor annular groove and a first rotor radial groove, the rotor internal flow channel inlet is located at the rotation axis to communicate with the first inlet and outlet hole, the rotor internal flow channel outlet is communicated with the rotor internal flow channel inlet through the rotor internal flow channel provided in the rotor, the rotor annular groove is provided around the rotor internal flow channel inlet, the rotor annular groove is communicated with the first stator radial groove and the second stator radial groove, the first rotor radial groove is communicated with the rotor annular groove, and a line connecting the rotor internal flow channel inlet and the rotor internal flow channel outlet and the first stator radial groove are on the same straight line;

[0008] When the rotor rotates relative to the stator, one of the first component connecting hole and the second component connecting hole of a pair of component connecting holes is connected to the first rotor radial groove, and the other is connected to the outlet of the rotor internal flow channel, or one of the first stator radial groove and the second stator radial groove is connected to the first rotor radial groove, and the other is connected to the outlet of the rotor internal flow channel.

[0009] In an optional embodiment, the first stator radial slot and the second stator radial slot both extend from a second radius from the rotation axis to a first radius from the rotation axis, and

[0010] The first component connection hole and the second component connection hole are both located at a first radius from the rotation axis.

[0011] In an optional embodiment, the outlet of the rotor internal flow channel is located at the first radius away from the rotation axis, the rotor annular groove has the rotation axis as the center and the second radius as the radius, and the first rotor radial groove extends from the second radius away from the rotation axis to the first radius away from the rotation axis.

[0012] In an optional embodiment, each first component connection hole of the multiple pairs of component connection holes is located on one side of a line connecting the first stator radial slot, the second stator radial slot and the first inlet and outlet hole, and each second component connection hole of the multiple pairs of component connection holes is located on the other side of a line connecting the first stator radial slot, the second stator radial slot and the first inlet and outlet hole.

[0013] In an optional implementation, the first radius is greater than the second radius.

[0014] In an optional embodiment, the rotor is a double-layer structure including a first rotor part and a second rotor part, the first rotor part and the second rotor part respectively have a third surface and a fourth surface, the third surface and the fourth surface are opposite to each other and sealedly connected, one of the third surface and the fourth surface is provided with a second rotor radial groove, and the second rotor radial groove forms the rotor internal flow channel when the third surface and the fourth surface are sealedly connected.

[0015] In an optional embodiment, the rotor is a single-layer structure, and the rotor internal flow channel is formed by driving two intersecting flow channels into the interior of the rotor from the rotor internal flow channel inlet and the rotor internal flow channel outlet on the second surface.

[0016] In an optional embodiment, the second inlet and outlet hole is arranged at any position within the length extension range of the first stator radial slot.

[0017] In an optional embodiment, the second inlet and outlet hole is arranged at the first radius away from the rotation axis.

[0018] In an optional embodiment, when the rotor rotates relative to the stator to a position where the first stator radial groove is connected to the first rotor radial groove and the second stator radial groove is connected to the rotor internal flow channel outlet, the liquid introduced into the rotary valve from the first inlet and outlet holes flows sequentially through the rotor internal flow channel inlet, the rotor internal flow channel, the rotor internal flow channel outlet, the second stator radial groove, the rotor annular groove, the first rotor radial groove, the first stator radial groove, and the second inlet and outlet holes, thereby flushing all flow channels inside the selection valve.

[0019] The above technical solution of the present application has the following beneficial technical effects:

[0020] The selection valve of the embodiment of the present application can be connected to multiple columns through multiple component connection holes, that is, the first component connection hole and the second component connection hole of a component connection hole are respectively connected to the forward interface and the reverse interface of a column, and then by rotating the rotor relative to the stator to different positions, the liquid can pass through a column in the forward direction, pass through a column in the reverse direction, or not pass through the column. It can be seen that the selection valve can replace multiple column position valves to realize the function of a combination of multiple column position valves. Therefore, using the selection valve in the chromatography system is conducive to reducing the number of valves and simplifying the structure of the chromatography system. In addition, when the liquid does not pass through the column, the liquid can flow through all the flow channels inside the selection valve to achieve flushing of all the flow channels inside the selection valve, thereby avoiding the selection valve from affecting the accuracy of subsequent analysis due to internal residues. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] The drawings described herein are used to provide a further understanding of the present disclosure and constitute a part of the present disclosure. The illustrative embodiments of the present disclosure and their descriptions are used to explain the present disclosure and do not constitute an improper limitation on the present disclosure. In the drawings:

[0022] Figure 1 A schematic diagram of the structure of a selector valve provided in an embodiment of the present application;

[0023] Figure 2 is a schematic diagram of a first surface structure of a stator in some embodiments;

[0024] Figure 3 is a schematic diagram of the back structure of a stator in some embodiments;

[0025] Figure 4 Schematic diagram of various dimensions of the stator in some embodiments;

[0026] Figure 5 is a schematic diagram of the second surface structure of the first rotor part in some embodiments;

[0027] Figure 6 is a schematic diagram of the third surface structure of the first rotor part in some embodiments;

[0028] Figure 7 Schematic diagram of various dimensions of the first rotor part in some embodiments;

[0029] Figure 8 is a schematic diagram of the fourth surface structure of the second rotor part in some embodiments;

[0030] Fig. 9 is a schematic diagram of the structure of a rotor in some embodiments;

[0031] Fig.10 A schematic diagram of a selector valve provided in an embodiment of the present application in a first rotation position;

[0032] Fig.11 This is a schematic diagram of a chromatography system using a selection valve provided in an embodiment of the present application when the selection valve is in a first rotation position and liquid passes through column A in a forward direction;

[0033] Fig.12 A schematic diagram of a selector valve provided in an embodiment of the present application in a second rotation position;

[0034] Fig.13 A schematic diagram of a chromatography system using a selection valve provided in an embodiment of the present application when the selection valve is in a second rotation position and liquid passes through column A in the reverse direction;

[0035] Fig.14A schematic diagram of a selector valve provided in an embodiment of the present application in a third rotation position;

[0036] Fig.15 A schematic diagram of a chromatography system using a selection valve provided in an embodiment of the present application when the selection valve is in a third rotation position and liquid does not pass through a column;

[0037] Reference numerals:

[0038] 100, selection valve; 110, stator; 111, first surface; 112, first inlet and outlet hole; 113, second inlet and outlet hole; 114, first stator radial groove; 115, second stator radial groove; 116, first component connecting hole; 117, second component connecting hole; 120, rotor; 121, first rotor part; 1211, second surface; 1212, rotor internal flow channel inlet; 1213, rotor internal flow channel outlet; 1214, rotor annular groove; 1215, first rotor radial groove; 1216, third surface; 1217, second rotor radial groove; 122, second rotor part; 1221, fourth surface. DETAILED DESCRIPTION

[0039] In order to enable those skilled in the art to better understand the technical solution of the present application, the present application is further described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0040] refer to Figures 1 to 15 The embodiment of the present application provides a selection valve 100, including: a stator 110 and a rotor 120 that can rotate relative to each other around a rotation axis L, and the stator 110 and the rotor 120 respectively have a first surface 111 and a second surface 1211 that are opposite to each other and dynamically sealed.

[0041] A surface of the rotor 120 opposite to the first surface 111 of the stator 110 is a second surface 1211 of the rotor 120 .

[0042] The dynamic sealing connection between the second surface 1211 of the rotor 120 and the first surface 111 of the stator may be that the second surface 1211 of the rotor 120 and the first surface 111 of the stator abut against each other and there is a certain extrusion force between the two.

[0043] For example, the stator 110 and the rotor 120 may be in the shape of a disk, and the sizes of the two may be similar. The rotation axis L when the rotor 120 can rotate relative to the stator 110 may pass through the center (center of the circle) of the stator 110 and the rotor 120. Of course, the shapes of the stator 110 and the rotor 120 may also be other shapes, such as square, prism, etc.

[0044] refer to Figure 2 and Figure 4The first surface 111 of the stator 110 is provided with a first inlet and outlet hole 112 and a second inlet and outlet hole 113. The first inlet and outlet hole 112 is located at the rotation axis L. The second inlet and outlet hole 113 is located at a first radius R1 from the rotation axis L, such as Figure 4 shown.

[0045] The first inlet and outlet hole 112 may be an inlet, and the second inlet and outlet hole 113 may be an outlet; or the first inlet and outlet hole 112 may be an outlet, and the second inlet and outlet hole 113 may be an inlet. In the following description, the first inlet and outlet hole 112 is an inlet (indicated by the letter IN in the figure) and the second inlet and outlet hole 113 is an outlet (indicated by the letter OUT in the figure) is used as an example for description.

[0046] refer to Figure 2 and Figure 4 , the first surface 111 of the stator 110 is provided with a first stator radial slot 114 and a second stator radial slot 115. The first stator radial slot 114 is connected to the second inlet and outlet hole 113, and the second stator radial slot 115 is symmetrically arranged with the first stator radial slot 114 about the first inlet and outlet hole 112, and the first stator radial slot 114 and the second stator radial slot 115 both extend from a second radius R2 from the rotation axis L to a first radius R1 from the rotation axis L, and R1>R2, as Figure 4 As shown. Since the first inlet and outlet hole 112 is located at the rotation axis L, the second stator radial slot 115 and the first stator radial slot 114 are symmetrically arranged about the rotation axis L. In this article, symmetrical arrangement means that the connecting line of the second stator radial slot 115 and the first inlet and outlet hole 112 and the connecting line of the first stator radial slot 114 and the first inlet and outlet hole 112 are on a straight line, and the distance between the second stator radial slot 115 and the first inlet and outlet hole 112 and the distance between the first stator radial slot 114 and the first inlet and outlet hole 112 are equal.

[0047] refer to Figure 2 and Figure 4 , a first surface 111 of the stator 110 is provided with a plurality of pairs of component connection holes, each pair of component connection holes includes a first component connection hole 116 and a second component connection hole 117, the first component connection hole 116 and the second component connection hole 117 are symmetrically arranged about the first inlet and outlet hole 112, and the first component connection hole 116 and the second component connection hole 117 are both located at a first radius R1 from the rotation axis L. That is, the distance from the first component connection hole 116 / the second component connection hole 117 to the rotation axis L (the first inlet and outlet hole 112) is equal to the distance from the second inlet and outlet hole 113 to the rotation axis L (the first inlet and outlet hole 112).

[0048] refer to Figure 5 and Figure 7, the second surface 1211 of the rotor 120 is provided with a rotor internal flow channel inlet 1212 and a rotor internal flow channel outlet 1213. The rotor internal flow channel inlet 1212 is located at the rotation axis L. That is, when the rotor 120 rotates relative to the stator 110, the rotor internal flow channel inlet 1212 can always be connected to the first inlet and outlet hole 112. The rotor internal flow channel outlet 1213 is located at a first radius R1 away from the rotation axis L. That is, when the rotor 120 rotates relative to the stator 110, the rotor internal flow channel outlet 1213 can be connected to the first stator radial groove 114 or the second stator radial groove 115 or a first component connection hole 116 or a second component connection hole 117. Of course, when the rotor internal flow channel outlet 1213 is connected to the first stator radial groove 114, the rotor internal flow channel outlet 1213 can also be connected to the second inlet and outlet hole 113 through the first stator radial groove 114. In this article, the rotor internal flow channel outlet 1213 and the rotor internal flow channel inlet 1212 are openings of the rotor internal flow channel disposed in the rotor 120 on the second surface 1211 of the rotor 120, and the connecting line of the rotor internal flow channel outlet 1213 and the rotor internal flow channel inlet 1212 is on the same straight line as the first stator radial slot 114. In this article, the term rotor internal flow channel refers to a rotor flow channel structure located inside the rotor and thus cannot be directly observed from the outside of the rotor.

[0049] refer to Figure 5 and Figure 7 The second surface 1211 of the rotor 120 is provided with a rotor annular groove 1214, and the rotor annular groove 1214 takes the rotation axis L as the center and has a radius of the second radius R2. In other words, the rotor annular groove 1214 is provided around the rotor internal flow channel inlet 1212, and when the rotor 120 rotates relative to the stator 110, the rotor annular groove 1214 can always be connected with the first stator radial groove 114 and the second stator radial groove 115.

[0050] refer to Figure 5 and Figure 7 , the second surface 1211 of the rotor 120 is provided with a first rotor radial groove 1215, and the first rotor radial groove 1215 extends from the second radius R2 away from the rotation axis L to the first radius R1 away from the rotation axis L. That is to say, the first rotor radial groove 1215 is connected with the rotor annular groove 1214, and when the rotor 120 rotates relative to the stator 110, the first rotor radial groove 1215 can be connected with the first stator radial groove 114 or the second stator radial groove 115 or a first component connection hole 116 or a second component connection hole 117. Of course, when the first rotor radial groove 1215 is connected with the first stator radial groove 114, the first rotor radial groove 1215 can also be connected with the second inlet and outlet hole 113 through the first stator radial groove 114.

[0051] The selection valve 100 of the embodiment of the present application can be connected to multiple columns through multiple pairs of component connection holes, that is, the first component connection hole 116 and the second component connection hole 117 of a pair of component connection holes are respectively connected to the forward interface and the reverse interface of a column. When the rotor 120 rotates relative to the stator 110, one of the first component connection hole 116 and the second component connection hole 117 of the pair of component connection holes can be connected to the first rotor radial groove 1215, and the other can be connected to the rotor internal flow channel outlet 1213. Alternatively, when the rotor 120 rotates relative to the stator 110, one of the first stator radial groove 114 and the second stator radial groove 115 can be connected to the first rotor radial groove 1215, and the other can be connected to the rotor internal flow channel outlet 1213. The selection valve 100 can realize that the liquid passes through a column in the forward direction, passes through a column in the reverse direction, or does not pass through the column by rotating the rotor 120 relative to the stator 110 to different positions.

[0052] Exemplary, reference Figure 2 and Figure 3 The first surface 111 is provided with five pairs of component connection holes, the first component connection holes 116 of the five pairs of component connection holes are respectively defined as interface 1, interface 2, interface 3, interface 4 and interface 5, and the second component connection holes 117 of the five pairs of component connection holes are respectively defined as interface A, interface B, interface C, interface D and interface E. Among them, interface 1 and interface A are respectively used to connect the forward interface and reverse interface of column A, interface 2 and interface B are respectively used to connect the forward interface and reverse interface of column B, interface 3 and interface C are respectively used to connect the forward interface and reverse interface of column C, interface 4 and interface D are respectively used to connect the forward interface and reverse interface of column D, and interface 5 and interface E are respectively used to connect the forward interface and reverse interface of column E.

[0053] refer to Figure 10 to Figure 11 When the rotor 120 rotates to the first position, the rotor internal flow channel outlet 1213 is connected to the interface 1, and the first rotor radial groove 1215 is connected to the interface A, so that the liquid can pass through the column A in the forward direction. The flow path direction is specifically: the first inlet and outlet hole 112→the rotor internal flow channel inlet 1212→the rotor internal flow channel→the rotor internal flow channel outlet 1213→the interface 1→the forward interface of the column A→the column 1→the reverse interface of the column A→the interface A→the first rotor radial groove 1215→the rotor annular groove 1214→the first stator radial groove 114→the second inlet and outlet hole 113.

[0054] refer to Figure 12 to Figure 13When the rotor 120 rotates to the second position, the rotor internal flow channel outlet 1213 is connected to the interface A, and the first rotor radial groove 1215 is connected to the interface 1, so that the liquid can pass through the column A in the reverse direction. The flow path direction is specifically: the first inlet and outlet hole 112→the rotor internal flow channel inlet 1212→the rotor internal flow channel→the rotor internal flow channel outlet 1213→the interface A→the reverse interface of the column A→the column A→the forward interface of the column A→the interface 1→the first rotor radial groove 1215→the rotor annular groove 1214→the first stator radial groove 114→the second inlet and outlet hole 113.

[0055] refer to Figure 14 to Figure 15 When the rotor 120 rotates to the third position, the rotor internal flow channel outlet 1213 is connected to the second stator radial groove 115, the first rotor radial groove 1215 is connected to the first stator radial groove 114 and the second inlet and outlet hole 113, and the liquid does not pass through the column. The flow path direction is specifically: first inlet and outlet hole 112→rotor internal flow channel inlet 1212→rotor internal flow channel→rotor internal flow channel outlet 1213→second stator radial groove 115→rotor annular groove 1214→first rotor radial groove 1215→first stator radial groove 114→second inlet and outlet hole 113.

[0056] By analogy, by rotating the rotor 120 relative to the stator 110 , the fluid can pass through one of the columns B, C, D and E in the forward or reverse direction.

[0057] It can be seen that the selector valve 100 can replace multiple column valves and realize the function of multiple column valve combinations. Therefore, using the selector valve 100 in a chromatography system is beneficial to reducing the number of valves and simplifying the structure of the system.

[0058] In addition, when the rotor 120 rotates to the third position, the liquid can flow through all the flow channels inside the selection valve 100. Therefore, when the rotor 120 is in the third position, the liquid is replaced with a cleaning liquid, and the cleaning liquid flows through all the flow channels inside the selection valve 100, so that all the flow channels inside the selection valve 100 can be flushed, thereby avoiding contamination caused by residue inside the selection valve 100 and affecting the accuracy of subsequent analysis.

[0059] In some embodiments, reference Figure 2 and Figure 3 The first inlet and outlet hole 112, the second inlet and outlet hole 113, the first component connecting hole 116 and the second component connecting hole 117 are all holes that penetrate the stator 110, that is, from Figure 2 The first surface 111 of the stator 110 shown extends through Figure 3 The stator 110 is shown with its back side facing opposite to the first surface 111 .

[0060] In some embodiments, reference Figure 2 and Figure 5 The first surface 111 and the second surface 1211 are both circular, and when the first surface 111 and the second surface 1211 are sealed and connected, the centers of the two coincide. In a specific configuration, the first inlet and outlet hole 112 is located at the center of the first surface 111, and the rotor internal flow channel inlet 1212 is located at the center of the second surface 1211. When the second surface 1211 rotates circumferentially relative to the first surface 111, the first inlet and outlet hole 112 and the rotor internal flow channel inlet 1212 can always remain connected.

[0061] In some embodiments, reference Figure 2 and Figure 5 The first stator radial slot 114 and the second stator radial slot 115 are both arranged along the radial direction of the first surface 111. The first rotor radial slot 1215 is arranged along the radial direction of the second surface 1211.

[0062] In some embodiments, reference Figure 3 The first component connection holes 116 and the second component connection holes 117 are arranged at intervals along the circumference of the first inlet and outlet hole 112, and the first component connection holes 116 and the second component connection holes 117 included in each pair of component connection holes are respectively located on opposite sides of the first inlet and outlet hole 112, and the angles between adjacent component connection holes can be equal or unequal. Figure 2 As shown, this embodiment shows that each first component connection hole 116 of the plurality of pairs of component connection holes is located on one side of the line connecting the first stator radial slot 114, the second stator radial slot 115 and the first inlet and outlet hole 112, and each second component connection hole 117 of the plurality of pairs of component connection holes is located on the other side of the line connecting the first stator radial slot 114, the second stator radial slot 115 and the first inlet and outlet hole 112. This arrangement makes the positions of the component connection holes more concentrated, and the rotor 120 rotates a small angle relative to the stator 110, that is, the fluid can pass through different columns, which is convenient for operating the selection valve 100.

[0063] In some embodiments, reference Figure 4 , the distance between the first component connection hole 116 / the second component connection hole 117 and the first inlet and outlet hole 112 is equal to the distance between the second inlet and outlet hole 113 and the first inlet and outlet hole 112, and the second inlet and outlet hole 113 is located at a first radius R1 from the rotation axis L. In this way, when the rotor 120 rotates to the third position, the distance between the end of the first rotor radial slot 1215 and the first inlet and outlet hole 112 is equal to the distance between the second inlet and outlet hole 113 and the first inlet and outlet hole 112, that is, the second inlet and outlet hole 113 is located at the end of the first rotor radial slot 1215, so that the first rotor radial slot 1215 can be thoroughly cleaned.

[0064] It is conceivable that the second inlet and outlet hole 113 does not have to be arranged at the first radius R1 from the rotation axis L, and the second inlet and outlet hole 113 can be arranged at any position within the length extension range of the first stator radial slot 114, and the first rotor radial slot 1215 can be well cleaned. That is, the distance between the second inlet and outlet hole 113 and the rotation axis L is less than the first radius R1 and greater than the second radius R2.

[0065] In some embodiments, reference Figure 4 The first stator radial slot 114 and the second stator radial slot 115 are located between the first component connection hole 116 (interfaces 1 to 5) and the second component connection hole 117 (interfaces A to E). Figure 4 As shown, this embodiment shows that the first component connection hole 116 and the second component connection hole 117 of each pair of component connection holes are symmetrically arranged along the center line of the first surface 111 , and the first stator radial slot 114 and the second stator radial slot 115 are arranged along the center line of the first surface 111 .

[0066] In some embodiments, reference Figure 5 , the rotor internal flow channel outlet 1213 and the first rotor radial groove 1215 are located in the area outside the rotor annular groove 1214. In other embodiments, the rotor internal flow channel outlet 1213 and the first rotor radial groove 1215 may be located in the area inside the rotor annular groove 1214.

[0067] In some embodiments, reference Figure 1 , Figure 6 and Figure 8 The rotor 120 is a double-layer structure including a first rotor part 121 and a second rotor part 122. The first rotor part 121 and the second rotor part 122 respectively have a third surface 1216 and a fourth surface 1221 facing each other. The third surface 1216 and the fourth surface 1221 are sealed and connected, and the third surface 1216 and the fourth surface 1221 form a part of the rotor internal flow channel when the third surface 1216 and the fourth surface 1221 are sealed and connected. Such a configuration can facilitate the provision of the rotor internal flow channel in the rotor 120, and can reduce the requirements for production equipment. It should be understood that in a specific implementation, the rotor internal flow channel inlet 1212 and the rotor internal flow channel outlet 1213 can be holes that penetrate the thickness of the first rotor part 121 and constitute a part of the rotor internal flow channel.

[0068] In some embodiments, reference Figure 6 and Figure 8 One of the third surface 1216 and the fourth surface 1221 is provided with a second rotor radial groove 1217, and the second rotor radial groove 1217 forms a part of the rotor internal flow channel when the third surface 1216 and the fourth surface 1221 are sealed and connected. Figure 6 , Figure 7 and Figure 8 As shown, this embodiment shows that a second rotor radial groove 1217 is provided on the third surface 1216, and the second rotor radial groove 1217 extends from the rotation axis L to a first radius R1 away from the rotation axis L, and the fourth surface 1221 is a plane. When the third surface 1216 and the fourth surface 1221 are sealed and connected, the fourth surface 1221 can close the second rotor radial groove 1217 on the third surface 1216 to form a part of the rotor internal flow channel. It should be understood that in a specific implementation, the third surface 1216 and the fourth surface 1221 are parallel to the second surface 1211, and the third surface 1216 and the second surface 1211 can be two side surfaces in the thickness direction of the first rotor part 121, that is, the third surface 1216 is the back side of the first rotor part 121 that is opposite to the second surface 1211.

[0069] In some embodiments, reference Fig. 9 The rotor 120 is a single-layer structure, and its rotor internal flow channel is formed by drilling or milling two intersecting flow channels from the center of the second surface 1211 (rotation axis L, rotor internal flow channel inlet 1212) and the first radius R1 from the rotation axis L (rotor internal flow channel outlet 1213) into the rotor interior. The two intersecting flow channels may be one extending longitudinally along the direction of the rotation axis, and the other extending obliquely in a direction forming an angle with the rotation axis, or both extending obliquely.

[0070] The above reference Figure 6 and Figure 8 The double-layer rotor described above may have a leakage problem due to poor sealing between the third surface 1216 and the fourth surface 1221. Although the single-layer rotor of this embodiment has higher requirements for the manufacturing precision of the two intersecting flow channels, it does not have the sealing problem of the double-layer structure.

[0071] The rotor of the single-layer structure can also be made by 3D printing technology. This arrangement can facilitate the formation of a rotor internal flow channel in the rotor 120, which is conducive to reducing the difficulty of producing the rotor 120.

[0072] It should be understood that the rotor internal flow channel can be Fig. 9 The V-shaped flow channel shown in the embodiment. Of course, the shape of the flow channel inside the rotor can also be other shapes, such as Figure 1 The U-shaped flow channel or arc-shaped flow channel shown in the embodiment.

[0073] In addition to the above-mentioned embodiments, those skilled in the art can also conceive of other forms of rotor internal flow channels, or other methods of processing the rotor internal flow channels, as long as a rotor internal flow channel can be formed that bypasses the rotor annular groove 1214 on the second surface 1211 from the inside of the rotor and connects the rotor internal flow channel inlet 1212 and the rotor internal flow channel outlet 1213.

[0074] The selection valve 100 of the embodiment of the present application can be connected to multiple columns through multiple component connection holes, that is, the first component connection hole 116 and the second component connection hole 117 of a component connection hole are respectively connected to the forward interface and the reverse interface of a column, and then by rotating the rotor 120 to different positions relative to the stator 110, it can be realized that the liquid passes through a column in the forward direction, passes through a column in the reverse direction, or does not pass through the column. It can be seen that the selection valve 100 can replace multiple column position valves to realize the function of a combination of multiple column position valves. Therefore, using the selection valve 100 in the chromatography system is conducive to reducing the number of valves and simplifying the structure of the chromatography system. In addition, when the liquid does not pass through the column, the liquid can flow through all the flow channels inside the selection valve 100 to achieve flushing of all the flow channels inside the selection valve 100, so as to avoid the selection valve 100 affecting the accuracy of subsequent analysis due to internal residues.

[0075] The embodiment of the present application also provides a chromatography system, including: multiple columns and a selection valve 100. The forward interface and the reverse interface of a column are respectively connected to the first component connection hole 116 and the second component connection hole 117 of a pair of component connection holes of the selection valve 100. The selection valve 100 can be connected to multiple columns through multiple component connection holes, that is, the first component connection hole 116 and the second component connection hole 117 of a component connection hole are respectively connected to the forward interface and the reverse interface of a column, and then by rotating the rotor 120 relative to the stator 110 to different positions, the liquid can pass through a column in the forward direction, pass through a column in the reverse direction, or not pass through the column. It can be seen that the selection valve 100 can replace multiple column position valves to realize the function of a combination of multiple column position valves. Therefore, using the selection valve 100 in the chromatography system is conducive to reducing the number of valves and simplifying the structure of the chromatography system. In addition, when the liquid does not pass through the column, the liquid can flow through all the flow channels inside the selection valve 100 to flush all the flow channels inside the selection valve 100, thereby preventing the selection valve 100 from affecting the accuracy of subsequent analysis due to internal residues.

[0076] The term "first" or "second" in the specification and claims of this application may include one or more of the features explicitly or implicitly. In the description of this application, unless otherwise specified, "plurality" means two or more. In addition, "and / or" in the specification and claims means at least one of the connected objects, and the character " / " generally means that the objects connected before and after are in an "or" relationship.

[0077] In the description of the present application, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "radial", "circumferential" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present application.

[0078] In the description of this application, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in this application can be understood according to specific circumstances.

[0079] One or more embodiments of this specification are intended to cover all such substitutions, modifications and variations that fall within the broad scope of the appended claims. Therefore, any omissions, modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of one or more embodiments of this specification should be included in the scope of protection of this application.

[0080] The above are only specific implementations of the present application, but the protection scope of the present application is not limited thereto. Any technician familiar with the technical field can easily think of changes or substitutions within the technical scope disclosed in the present application, which should be included in the protection scope of the present application. Therefore, the protection scope of the present application should be based on the protection scope of the claims.

Claims

1. A selector valve, characterized in that: include: A stator and a rotor capable of relatively rotating about a rotation axis, wherein the stator and the rotor respectively have a first surface and a second surface facing each other and dynamically sealed; The first surface is provided with a first inlet and outlet hole, a second inlet and outlet hole, a first stator radial slot, a second stator radial slot and a plurality of pairs of component connection holes, the first stator radial slot is connected with the second inlet and outlet hole, the first inlet and outlet hole is located at the rotation axis, the second stator radial slot and the first stator radial slot are symmetrically arranged with respect to the first inlet and outlet hole, each pair of the component connection holes comprises a first component connection hole and a second component connection hole, respectively, and the first component connection hole and the second component connection hole are symmetrically arranged with respect to the first inlet and outlet hole; The second surface is provided with a rotor internal flow channel inlet, a rotor internal flow channel outlet, a rotor annular groove and a first rotor radial groove, the rotor internal flow channel inlet is located at the rotation axis to communicate with the first inlet and outlet hole, the rotor internal flow channel outlet is communicated with the rotor internal flow channel inlet through the rotor internal flow channel provided in the rotor, the rotor annular groove is provided around the rotor internal flow channel inlet, the rotor annular groove is communicated with the first stator radial groove and the second stator radial groove, the first rotor radial groove is communicated with the rotor annular groove, and a line connecting the rotor internal flow channel inlet and the rotor internal flow channel outlet and the first stator radial groove are on the same straight line; When the rotor rotates relative to the stator, one of the first component connecting hole and the second component connecting hole of a pair of component connecting holes is connected to the first rotor radial groove, and the other is connected to the outlet of the rotor internal flow channel, or one of the first stator radial groove and the second stator radial groove is connected to the first rotor radial groove, and the other is connected to the outlet of the rotor internal flow channel.

2. The selector valve according to claim 1, characterized in that: The first stator radial slot and the second stator radial slot each extend from a second radius from the rotation axis to a first radius from the rotation axis, and The first component connection hole and the second component connection hole are both located at a first radius from the rotation axis.

3. The selector valve according to claim 2, characterized in that: The outlet of the rotor internal flow channel is located at the first radius away from the rotation axis, the rotor annular groove has the rotation axis as the center and the radius as the second radius, and the first rotor radial groove extends from the second radius away from the rotation axis to the first radius away from the rotation axis.

4. The selector valve according to claim 1, characterized in that: Each first component connection hole of the multiple pairs of component connection holes is located on one side of a line connecting the first stator radial slot, the second stator radial slot and the first inlet and outlet hole, and each second component connection hole of the multiple pairs of component connection holes is located on the other side of a line connecting the first stator radial slot, the second stator radial slot and the first inlet and outlet hole.

5. The selector valve according to claim 3, characterized in that: The first radius is greater than the second radius.

6. The selector valve according to claim 1, characterized in that: The rotor is a double-layer structure including a first rotor part and a second rotor part, the first rotor part and the second rotor part respectively have a third surface and a fourth surface, the third surface and the fourth surface are opposite to each other and sealed, one of the third surface and the fourth surface is provided with a second rotor radial groove, and the second rotor radial groove forms the rotor internal flow channel when the third surface and the fourth surface are sealed.

7. The selector valve according to claim 1, characterized in that: The rotor is a single-layer structure, and the rotor internal flow channel is formed by punching two mutually intersecting flow channels into the rotor from the rotor internal flow channel inlet and the rotor internal flow channel outlet on the second surface.

8. The selector valve according to claim 2, characterized in that: The second access hole is arranged at any position within the length extension range of the first stator radial slot.

9. The selector valve according to claim 8, characterized in that: The second inlet and outlet hole is disposed at the first radius from the rotation axis.

10. The selector valve according to claim 1, characterized in that: When the rotor rotates relative to the stator to a position where the first stator radial groove is connected to the first rotor radial groove and the second stator radial groove is connected to the outlet of the rotor internal flow channel, the liquid introduced into the rotary valve from the first inlet and outlet holes flows sequentially through the rotor internal flow channel inlet, the rotor internal flow channel, the rotor internal flow channel outlet, the second stator radial groove, the rotor annular groove, the first rotor radial groove, the first stator radial groove, and the second inlet and outlet holes, thereby flushing all the flow channels inside the selection valve.

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