Novel blood glucose test paper with high compatibility and wide detection range and preparation method of novel blood glucose test paper

Abstract

The invention belongs to the technical field of blood glucose test paper, and particularly relates to novel blood glucose test paper with high compatibility and wide detection range and a preparation method of the novel blood glucose test paper. The blood glucose test strip prepared by the invention can be adapted to various types of blood glucose meters, reduces the trouble and extra cost when a patient replaces equipment, has better stability and accuracy, and can provide consistent test results under different environmental conditions, thereby improving the reliability of blood glucose monitoring, and being suitable for popularization and application. The prepared blood glucose test paper can detect the wide blood glucose concentration from hypoglycemia to hyperglycemia, and can cover a wider blood glucose range, so that the prepared blood glucose test paper provides more data points for patients, helps the patients to comprehensively understand their own blood glucose change trends, and has good application prospects. Patients can better control diet, exercise and medicine, the risk of hypoglycemia and hyperglycemia is reduced, and the management effect of diabetes is improved.

Description

Technical Field

[0001] The invention belongs to the technical field of blood sugar test strips, and in particular relates to a novel blood sugar test strip with high compatibility and a wide detection range and a preparation method thereof. Background Art

[0002] Diabetes is a common chronic metabolic disease, and patients need to monitor their blood sugar levels regularly in order to control the disease and reduce the risk of complications. As a convenient self-blood sugar monitoring tool, blood sugar test strips provide diabetic patients with a simple, economical and efficient way to test their blood sugar. Before the popularization of blood sugar test strips, diabetic patients mainly relied on urine tests for blood sugar testing, which indirectly reflected blood sugar levels through urine sugar. The accuracy of urine sugar tests is poor, because sugar is only excreted through urine when blood sugar reaches a certain threshold (usually about 180mg / dL or 10mmol / L), and early changes in blood sugar cannot be captured. Therefore, urine sugar tests cannot effectively monitor the blood sugar levels of diabetic patients, nor are they suitable for meticulous blood sugar management.

[0003] Chinese patent publication number CN113588935A discloses an electrochemical barcode-free blood glucose test strip and a preparation method thereof, which covers an enzyme membrane on a PET substrate and performs test compensation through HCT to obtain more accurate test results. Its use process is complicated and is not suitable for different types of home blood glucose meters on the market. Chinese patent publication number CN111366623A discloses an electrochemical blood glucose test strip with a temperature label, a preparation process and a method of use. During use, it still has problems such as insufficient accuracy, low sensitivity and limited detection range. When blood glucose is too low or too high, the blood glucose result cannot be measured quickly and accurately.

[0004] In view of the above technical defects, a solution is now proposed. Summary of the invention

[0005] The purpose of the present invention is to provide a new type of blood glucose test strip with high compatibility and wide detection range and a preparation method thereof. The test strip has high compatibility and can be applied to different blood glucose testers on the market while having a wide detection range.

[0006] To achieve the above-mentioned purpose, the present invention adopts the following technical scheme: a novel blood glucose test strip with high compatibility and wide detection range is prepared by coating a blood glucose test strip reaction solution on a water-absorbing material and then bonding it to a plastic base plate, wherein the blood glucose test strip reaction solution is composed of the following percentage components: 45-50% phosphate buffer, 1.5-2% glucose oxidase, 43-45% physiological saline, 0.5-1% nano-platinum, 1-1.5% catalase, 0.5-1% nicotinamide adenine dinucleotide, 1-1.5% coenzyme Q and 1-2% ascorbic acid; the plastic base plate is composed of the following percentage components: 15-20% polyimide film, 30-35% polybutylene terephthalate, 30-35% polytrimethylene terephthalate and 15-20% polypropylene;

[0007] The method for preparing the blood sugar test strip reaction solution comprises the following steps:

[0008] A1: Glucose oxidase, catalase, nicotinamide adenine dinucleotide, coenzyme Q and phosphate buffer were added into a reaction kettle, and the reaction kettle was placed on a magnetic stirrer, heated in a water bath, the temperature was set to 35-45°C, the speed was set to 600-800 rpm, and stirred for 25-30 min to obtain material 1;

[0009] A2: Add nano-platinum, ascorbic acid and physiological saline to a reactor, place the reactor on a magnetic stirrer, heat in a water bath, set the temperature to 55-65°C, set the speed to 1000-1200 rpm, and stir for 45-60 min to obtain material 2;

[0010] A3: Cool material 1 and material 2 to room temperature, mix material 1 and material 2 after cooling to room temperature, place in a magnetic stirrer, set the speed to 600-800rpm and stir for 30min, after material 1 and material 2 are mixed, use ammonia water and 9% glacial acetic acid to adjust the pH to 5.5-5.8 to obtain a blood glucose test strip reaction solution;

[0011] The method for preparing the plastic base plate comprises the following steps:

[0012] B1: Put polyimide film, polybutylene terephthalate, polypropylene terephthalate and polypropylene into a high-pressure reactor, set the reactor temperature to 110-125°C, the reactor pressure to 2.2-2.4atm, set the reactor magnetic stirrer speed to 1000-1200rpm, and stir and hot melt for 30-45min;

[0013] B2: After hot melting, transfer to a homogenizer and homogenize for 5-10 minutes. After homogenization, transfer to a mold and cold press to obtain a plastic base plate for a blood glucose test strip.

[0014] Furthermore, the nano-platinum is white nano-platinum powder with a particle size of 20 nm; the nicotinamide adenine dinucleotide is white nicotinamide adenine dinucleotide powder with a specification of 200 mesh; the polyimide film is a non-sticky brown polyimide film with a thickness of 0.075-0.09 mm; the specifications of the plastic base plate of the blood glucose test strip in step B2 are 42 mm in length, 7 mm in width, and 0.4 mm in thickness.

[0015] Furthermore, a method for preparing a novel blood glucose test strip with high compatibility and wide detection range comprises the following steps:

[0016] C1: The absorbent material is bonded to the plastic base plate using a medical water-based adhesive, and then the blood glucose test strip reaction solution is coated on the absorbent material using a coating machine, and then transferred to a dryer for drying at 55°C and a wind speed of 1.5m / s for 30min;

[0017] C2: After drying, the electrode material is attached, and then a 0.05 mm polypropylene film is bonded to the dried absorbent material using a medical water-based adhesive. After bonding, it is transferred to a screen printer, and tin oxide is used as the screen printing material. 0.1 mm tin oxide is screen-printed on the polypropylene film to produce a new type of blood glucose test strip with high compatibility and a wide detection range.

[0018] Furthermore, the water-absorbing material in step C1 is a round mesh polypropylene non-woven fabric with a gram weight of 60 g / m 2 ; The electrode materials in step C2 are silver sheets and carbon sheets with a length of 2.5 mm, a width of 1.2 mm, and a thickness of 0.02 mm; the coating thickness of the blood glucose test strip reaction solution in step C1 is 0.05-0.08 mm;

[0019] Further, the medical water-based adhesive in step S7 is composed of the following percentage components: 20-25% polyacrylic acid, 10-15% polyvinyl alcohol, 20-25% polyurethane, 8-10% glycerol, 15-20% isocyanate, 1-2% vitamin E and the balance water;

[0020] The preparation method of the medical water-based adhesive comprises the following steps:

[0021] D1: Add polypropylene, polyvinyl alcohol, and polyurethane into pure water, adjust the temperature of the reactor to 80-85°C, adjust the speed of the stirrer to 800-1000 rpm, stir and dissolve for 30 minutes, then adjust the pH to 5.8-6.4 with acetic acid and ammonia water, and continue stirring for 30 minutes to obtain a resin copolymer;

[0022] D2: adding isocyanate and glycerol into pure water, adjusting the temperature of the reactor to 55-60°C, adjusting the speed of the stirrer to 800-1000 rpm, stirring and dissolving for 30 minutes to obtain a cyanate glycerol mixture;

[0023] D3: Mix the resin copolymer and the cyanate glycerol mixture, set the reactor temperature to 85-90°C, then add vitamin E, adjust the stirrer speed to 1200-1500 rpm, mix and stir for 1.5-2h, and obtain a medical water-based adhesive after stirring.

[0024] To sum up, due to the adoption of the above-mentioned technical scheme, the beneficial effects of the present invention are that the blood glucose test strips prepared by the present invention can be adapted to various models of blood glucose meters, reducing the trouble and additional costs of patients when replacing equipment, and at the same time having better stability and accuracy, and can provide consistent test results under different environmental conditions, thereby improving the reliability of blood glucose monitoring, and the blood glucose test strips prepared by the present invention can detect a wide range of blood glucose concentrations from hypoglycemia to hyperglycemia. By being able to cover a wider blood glucose range, the blood glucose test strips prepared by the present invention provide patients with more data points, helping them to fully understand their blood glucose change trends, and patients can better control diet, exercise and medication, reduce the risks of hypoglycemia and hyperglycemia, and improve the management effect of diabetes. DETAILED DESCRIPTION

[0025] In order to make the technical means, creative features, objectives and effects achieved by the present invention easy to understand, the present invention is further described below in conjunction with specific embodiments.

[0026] The experimental methods in the following examples, unless otherwise specified, are conventional methods, and are performed according to the techniques or conditions described in the literature in the field or according to the product instructions. The materials and reagents used in the following examples, unless otherwise specified, can be obtained from commercial channels.

[0027] Example 1

[0028] 1: Weigh the following raw materials according to mass percentage: 100 g phosphate buffer, 3 g glucose oxidase, 86 g normal saline, 1 g nanoplatinum, 2 g catalase, 1 g nicotinamide adenine dinucleotide, 2 g coenzyme Q and 2 g ascorbic acid;

[0029] 2: Glucose oxidase, catalase, nicotinamide adenine dinucleotide, coenzyme Q and phosphate buffer were added into the reactor, the reactor was placed on a magnetic stirrer, heated in a water bath, the temperature was set to 35°C, the speed was set to 800 rpm, and stirred for 30 min to obtain material 1;

[0030] 3: Add nano-platinum, ascorbic acid and physiological saline to a reactor, place the reactor on a magnetic stirrer for water bath heating, set the temperature to 65°C, set the speed to 1200 rpm, and stir for 60 min to obtain material 2;

[0031] 4: Cool material 1 and material 2 to room temperature, mix material 1 and material 2 after cooling to room temperature, place in a magnetic stirrer, set the speed to 800 rpm and stir for 30 min, after material 1 and material 2 are mixed, use ammonia water and 9% glacial acetic acid to adjust the pH to 5.8 to obtain the blood glucose test strip reaction solution prepared in Example 1;

[0032] Table 1,

[0033]

[0034]

[0035] The reagents and parameters used in Example 1 are shown in Table 1.

[0036] Example 2

[0037] 1: Weigh the following raw materials according to mass percentage: 90g phosphate buffer, 4g glucose oxidase, 90g normal saline, 2g nanoplatinum, 3g catalase, 2g nicotinamide adenine dinucleotide, 3g coenzyme Q and 4g ascorbic acid;

[0038] 2: Glucose oxidase, catalase, nicotinamide adenine dinucleotide, coenzyme Q and phosphate buffer were added into the reactor, the reactor was placed on a magnetic stirrer, heated in a water bath, the temperature was set to 45°C, the speed was set to 600 rpm, and stirred for 25 min to obtain material 1;

[0039] 3: Add nano-platinum, ascorbic acid and physiological saline to a reactor, place the reactor on a magnetic stirrer for water bath heating, set the temperature to 55°C, set the speed to 1000 rpm, and stir for 45 minutes to obtain material 2;

[0040] 4: Cool material 1 and material 2 to room temperature, mix material 1 and material 2 after cooling to room temperature, place in a magnetic stirrer, set the speed to 600 rpm and stir for 30 min, after material 1 and material 2 are mixed, use ammonia water and 9% glacial acetic acid to adjust the pH to 5.5 to obtain the blood glucose test strip reaction solution prepared in Example 2;

[0041] Table 2

[0042]

[0043]

[0044] The reagents and parameters used in Example 2 are shown in Table 2.

[0045] Example 3

[0046] 1: Add 40g of polypropylene, 20g of polyvinyl alcohol and 40g of polyurethane into pure water, adjust the temperature of the reactor to 85°C, adjust the speed of the stirrer to 1000rpm, stir and dissolve for 30min, then adjust the pH to 5.8 with acetic acid and ammonia water, and continue stirring for 30min to obtain a resin copolymer;

[0047] 2: Add 40g of isocyanate and 20g of glycerol into pure water, adjust the temperature of the reactor to 60°C, adjust the speed of the stirrer to 1000rpm, stir and dissolve for 30min to obtain a cyanate glycerol mixture;

[0048] 3: Mix the resin copolymer and the cyanate glycerol mixture, set the reactor temperature to 90°C, then add 4g of vitamin E, adjust the stirrer speed to 1500rpm, mix and stir for 2h, and after stirring, obtain the medical water-based adhesive prepared in Example 3.

[0049] Table 3

[0050] Drug Name source model parameter Polyacrylic acid Changzhou Runyang Chemical Co., Ltd. GY-303 1kg Polyvinyl alcohol Langfang Feitai New Material Technology Co., Ltd. 2488-5 1kg Polyurethane Anhui Yuanchen New Material Technology Co., Ltd. YC-305 1kg glycerin Nanjing Rongji Chemical Co., Ltd. RJ-BSC-01 1kg Isocyanate Shanghai Kaizhi New Material Technology Co., Ltd. 44V20L 1kg Vitamin E Xi'an Miaoguo Biotechnology Co., Ltd. MG-20230222 1kg

[0051] The reagents and parameters used in Example 3 are shown in Table 3.

[0052] Example 4

[0053] 1: Add 50g of polypropylene, 30g of polyvinyl alcohol and 50g of polyurethane into pure water, adjust the temperature of the reactor to 85°C, adjust the speed of the stirrer to 1000rpm, stir and dissolve for 30min, then adjust the pH to 6.4 with acetic acid and ammonia water, and continue stirring for 30min to obtain a resin copolymer;

[0054] 2: Add 30g of isocyanate and 16g of glycerol into pure water, adjust the temperature of the reactor to 60°C, adjust the speed of the stirrer to 1000rpm, stir and dissolve for 30min to obtain a cyanate glycerol mixture;

[0055] 3: Mix the resin copolymer and the cyanate glycerol mixture, set the reactor temperature to 85°C, then add 2g of vitamin E, adjust the stirrer speed to 1200rpm, mix and stir for 2h, and after stirring, obtain the medical water-based adhesive prepared in Example 4.

[0056] Table 4

[0057] Drug Name source model parameter Polyacrylic acid Changzhou Runyang Chemical Co., Ltd. GY-303 1kg Polyvinyl alcohol Langfang Feitai New Material Technology Co., Ltd. 2488-5 1kg Polyurethane Anhui Yuanchen New Material Technology Co., Ltd. YC-305 1kg glycerin Nanjing Rongji Chemical Co., Ltd. RJ-BSC-01 1kg Isocyanate Shanghai Kaizhi New Material Technology Co., Ltd. 44V20L 1kg Vitamin E Xi'an Miaoguo Biotechnology Co., Ltd. MG-20230222 1kg

[0058] The reagents and parameters used in Example 4 are shown in Table 4.

[0059] Example 5

[0060] 1: Weigh the following raw materials according to mass percentage: 40g polyimide film, 70g polybutylene terephthalate, 70g polypropylene terephthalate and 40g polypropylene;

[0061] 2: Put polyimide film, polybutylene terephthalate, polypropylene terephthalate and polypropylene into a high-pressure reactor, set the reactor temperature to 125°C, the reactor pressure to 2.4 atm, set the reactor magnetic stirrer speed to 1200 rpm, stir and hot melt for 45 minutes, transfer to a homogenizer after hot melting, homogenize for 10 minutes, transfer to a mold after homogenization, and cold press to obtain a plastic base plate for a blood glucose test strip;

[0062] 3: The round mesh polypropylene non-woven fabric is bonded to the plastic base plate using the medical water-based adhesive prepared in Example 3, and then the blood glucose test strip reaction solution prepared in Example 1 is coated on the water-absorbing material using a coating machine, with a coating thickness of 0.05 mm, and then transferred to a dryer for drying at 55°C and a wind speed of 1.5 m / s for 30 min. After drying, a silver sheet and a carbon sheet are attached, and then a 0.05 mm polypropylene film is bonded to the dried water-absorbing material using the medical water-based adhesive prepared in Example 3. After bonding, it is transferred to a screen printer, and tin oxide is used as the screen printing material. 0.1 mm tin oxide is screen-printed on the polypropylene film to obtain a new type of blood glucose test strip with high compatibility and a wide detection range as prepared in Example 5.

[0063] Table 5

[0064]

[0065] The reagents and parameters used in Example 5 are shown in Table 5.

[0066] Example 6

[0067] 1: Weigh the following raw materials according to mass percentage: 30g polyimide film, 60g polybutylene terephthalate, 60g polypropylene terephthalate and 30g polypropylene;

[0068] 2: Put polyimide film, polybutylene terephthalate, polypropylene terephthalate and polypropylene into a high-pressure reactor, set the reactor temperature to 110°C, the reactor pressure to 2.2 atm, set the reactor magnetic stirrer speed to 1000 rpm, stir and hot melt for 30 minutes, transfer to a homogenizer after hot melting, homogenize for 5 minutes, transfer to a mold after homogenization, and cold press to obtain a plastic base plate for a blood glucose test strip;

[0069] 3: The round mesh polypropylene non-woven fabric is bonded to the plastic base plate using the medical water-based adhesive prepared in Example 4, and then the blood glucose test strip reaction solution prepared in Example 2 is coated on the water-absorbing material using a coating machine, with a coating thickness of 0.08 mm, and then transferred to a dryer for drying at 55°C and a wind speed of 1.5 m / s for 30 min. After drying, a carbon sheet and a silver sheet are attached, and then a 0.05 mm polypropylene film is bonded to the dried water-absorbing material using the medical water-based adhesive prepared in Example 4. After bonding, it is transferred to a screen printer, and tin oxide is used as the screen printing material. 0.1 mm tin oxide is screen-printed on the polypropylene film to obtain a new type of blood glucose test strip with high compatibility and a wide detection range as prepared in Example 5.

[0070] Table 6, reagent parameters used in Example 6

[0071]

[0072] The reagents and parameters used in Example 6 are shown in Table 6.

[0073] Comparative Example 1

[0074] Example 1 of Chinese patent publication number CN113588935A was selected as comparative example 1.

[0075] Comparative Example 2

[0076] Example 1 of the Chinese patent with publication number CN111366623A was selected as comparative example 2.

[0077] Physical performance test:

[0078] The resistivity of the blood glucose test strips prepared in Example 5, Example 6, Comparative Example 1 and Comparative Example 2 was tested by a four-probe method, and the resistivity was retested by the same method after being placed at room temperature for 6 months; the enzyme film layer of the blood glucose test strips prepared in Example 5, Example 6, Comparative Example 1 and Comparative Example 2 was rubbed 10 times to observe whether the dried enzyme film was detached from the substrate, so as to evaluate the adhesion of the enzyme film; the sensitivity of the blood glucose test strips was calculated using an electrochemical base station test.

[0079] Table 7, Physical properties test results

[0080] Example 5 Example 6 Comparative Example 1 Comparative Example 2 Resistivity (Ω·cm) 0.0099 0.0105 0.0178 0.0217 Resistivity after half a year (Ω·cm) 0.0108 0.0109 0.0195 0.0218 Adhesion No shedding No shedding 10% shedding 20% shedding Sensitivity (μA / mmol / L) 0.237 0.222 0.317 0.323

[0081] From the analysis of Table 7, it can be seen that the enzyme membrane layer of the blood glucose test strips prepared in Example 3 and Example 4 is not easy to fall off under the action of external force and has a low resistivity, and has good sensitivity and stability during normal use.

[0082] Response time and accuracy test:

[0083] Glucose and 0.9% NaCl solution were used to prepare blood glucose quality control solutions of different concentrations, and baking soda and normal saline were used to adjust the pH to 7.35±0.05. The commercially available Yuyueyuezhun type 1 710 household code-free blood glucose meter was used to test the blood glucose content using Example 5, Example 6, Comparative Example 1, Comparative Example 2 and self-contained blood glucose test strips, and the response time was recorded.

[0084] Table 8, Response time test results

[0085] Response time(S) Example 5I 6.8 Example 5II 6.7 Example 6I 6.5 Example 6II 6.6 Comparative Example 1Ⅰ 7.9 Comparative Example 1Ⅱ 8.1 Comparative Example 2Ⅰ 9.2 Comparative Example 2Ⅱ 9.5 Self-containedⅠ 9.4 Self-contained Ⅱ 9.7

[0086] Table 9, accuracy test results

[0087]

[0088]

[0089] By analyzing Table 8 and Table 9, it can be seen that the blood glucose test strips prepared in Example 5 and Example 6 have faster response time and response accuracy than those prepared in Comparative Example 1 and Comparative Example 2.

[0090] Detection range and compatibility test

[0091] 20 home-use code-free blood glucose meters were purchased from the market, and blood glucose quality control solutions with concentrations of 1.5 mmol / L and 200.5 mmol / L were prepared using glucose and 0.9% NaCl solution, respectively marked as low blood glucose content and high blood glucose content, and the pH was adjusted to 7.35 using baking soda and normal saline, and the blood glucose content was detected using Example 5, Example 6, Comparative Example 1, and Comparative Example 2, respectively;

[0092] Table 10, Low Blood Glucose Content Test

[0093] Example 5 Example 6 Comparative Example 1 Comparative Example 2 Blood glucose meter1 1.5mmol / L 1.5mmol / L 1.5mmol / L 1.6mmol / L Blood glucose meter 2 1.5mmol / L 1.6mmol / L No data 1.6mmol / L Blood glucose meter 3 1.5mmol / L 1.5mmol / L 1.5mmol / L No data Blood glucose meter 4 1.6mmol / L 1.6mmol / L 1.6mmol / L No data Blood glucose meter 5 1.5mmol / L 1.6mmol / L No data No data

[0094] Table 11, High Blood Glucose Content Test

[0095]

[0096]

[0097] By analyzing Table 10 and Table 11, it can be seen that the blood glucose test strips prepared in Example 5 and Example 6 can accurately measure blood glucose values ​​under hypoglycemia and hyperglycemia conditions and are suitable for different blood glucose meters.

[0098] The above shows and describes the basic principles and main features of the present invention and the advantages of the present invention. It should be understood by those skilled in the art that the present invention is not limited to the above embodiments. The above embodiments and descriptions are only for explaining the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, which fall within the scope of the present invention to be protected. The scope of protection of the present invention is defined by the attached claims and their equivalents.

Claims

1. A new type of blood glucose test strip with high compatibility and wide detection range, characterized in that: A novel blood glucose test strip with high compatibility and wide detection range is prepared by coating a blood glucose test strip reaction solution on a water-absorbing material and then bonding it to a plastic base plate, wherein the blood glucose test strip reaction solution is composed of the following percentage components: 45-50% phosphate buffer, 1.5-2% glucose oxidase, 43-45% physiological saline, 0.5-1% nanoplatinum, 1-1.5% catalase, 0.5-1% nicotinamide adenine dinucleotide, 1-1.5% coenzyme Q and 1-2% ascorbic acid; the plastic base plate is composed of the following percentage components: 15-20% polyimide film, 30-35% polybutylene terephthalate, 30-35% polytrimethylene terephthalate and 15-20% polypropylene; The method for preparing the blood sugar test strip reaction solution comprises the following steps: A1: Glucose oxidase, catalase, nicotinamide adenine dinucleotide, coenzyme Q and phosphate buffer were added into a reaction kettle, and the reaction kettle was placed on a magnetic stirrer, heated in a water bath, the temperature was set to 35-45°C, the speed was set to 600-800 rpm, and stirred for 25-30 min to obtain material 1; A2: Add nano-platinum, ascorbic acid and physiological saline to a reactor, place the reactor on a magnetic stirrer, heat in a water bath, set the temperature to 55-65°C, set the speed to 1000-1200 rpm, and stir for 45-60 min to obtain material 2; A3: Cool material 1 and material 2 to room temperature, mix material 1 and material 2 after cooling to room temperature, place in a magnetic stirrer, set the speed to 600-800rpm and stir for 30min, after material 1 and material 2 are mixed, use ammonia water and 9% glacial acetic acid to adjust the pH to 5.5-5.8 to obtain a blood glucose test strip reaction solution; The method for preparing the plastic base plate comprises the following steps: B1: Put polyimide film, polybutylene terephthalate, polypropylene terephthalate and polypropylene into a high-pressure reactor, set the reactor temperature to 110-125°C, the reactor pressure to 2.2-2.4atm, set the reactor magnetic stirrer speed to 1000-1200rpm, and stir and hot melt for 30-45min; B2: After hot melting, transfer to a homogenizer and homogenize for 5-10 minutes. After homogenization, transfer to a mold and cold press to obtain a plastic base plate for a blood glucose test strip.

2. A novel blood glucose test strip with high compatibility and wide detection range according to claim 1, characterized in that: The nano platinum is white nano platinum powder with a particle size of 20 nm.

3. A novel blood glucose test strip with high compatibility and wide detection range according to claim 1, characterized in that: The nicotinamide adenine dinucleotide is white nicotinamide adenine dinucleotide powder.

4. A novel blood glucose test strip with high compatibility and wide detection range according to claim 1, characterized in that: The polyimide film is a non-sticky brown polyimide film with a thickness of 0.075-0.09 mm.

5. A novel blood glucose test strip with high compatibility and wide detection range according to claim 1, characterized in that: The specifications of the plastic base plate of the blood glucose test strip described in step B2 are 42 mm in length, 7 mm in width and 0.4 mm in thickness.

6. The method for preparing a novel blood glucose test strip with high compatibility and wide detection range according to claim 1, characterized in that: The following steps are involved: C1: The absorbent material is bonded to the plastic base plate using a medical water-based adhesive, and then the blood glucose test strip reaction solution is coated on the absorbent material using a coating machine, and then transferred to a dryer for drying at 55°C and a wind speed of 1.5m / s for 30min; C2: After drying, the electrode material is attached, and then a 0.05 mm polypropylene film is bonded to the dried absorbent material using a medical water-based adhesive. After bonding, it is transferred to a screen printer, and tin oxide is used as the screen printing material. 0.1 mm tin oxide is screen-printed on the polypropylene film to produce a new type of blood glucose test strip with high compatibility and a wide detection range.

7. The method for preparing a novel blood glucose test strip with high compatibility and wide detection range according to claim 7, characterized in that: The water-absorbing material in step C1 is a round mesh polypropylene non-woven fabric with a gram weight of 60 g / m 2 .

8. The method for preparing a novel blood glucose test strip with high compatibility and wide detection range according to claim 7, characterized in that: The electrode materials in step C2 are silver sheets and carbon sheets with a length of 2.5 mm, a width of 1.2 mm, and a thickness of 0.02 mm.

9. The method for preparing a novel blood glucose test strip with high compatibility and wide detection range according to claim 7, characterized in that: The coating thickness of the blood glucose test strip reaction solution in step C1 is 0.05-0.08 mm.

10. A method for preparing a novel blood glucose test strip with high compatibility and wide detection range according to claim 7, characterized in that: The medical water-based adhesive described in step C1 is composed of the following percentage components: 20-25% polyacrylic acid, 10-15% polyvinyl alcohol, 20-25% polyurethane, 8-10% glycerol, 15-20% isocyanate, 1-2% vitamin E and the balance water; The preparation method of the medical water-based adhesive comprises the following steps: D1: Add polypropylene, polyvinyl alcohol, and polyurethane into pure water, adjust the temperature of the reactor to 80-85°C, adjust the speed of the stirrer to 800-1000 rpm, stir and dissolve for 30 minutes, then add acetic acid, and continue stirring for 30 minutes to obtain a resin copolymer; D2: adding isocyanate and glycerol into pure water, adjusting the temperature of the reactor to 55-60°C, adjusting the speed of the stirrer to 800-1000 rpm, stirring and dissolving for 30 minutes to obtain a cyanate glycerol mixture; D3: Mix the resin copolymer and the cyanate glycerol mixture, set the reactor temperature to 85-90°C, then add vitamin E, adjust the stirrer speed to 1200-1500 rpm, mix and stir for 1.5-2h, and obtain a medical water-based adhesive after stirring.

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