Traditional Chinese medicine dropping pill coating material containing angelica volatile oil and coating method

Abstract

The invention discloses a traditional Chinese medicine dropping pill coating material containing angelica volatile oil and a coating method, belongs to the technical field of application of angelica volatile oil, and aims to solve the problem that effective components are easy to lose due to a simple coating process of the angelica volatile oil. The coating material is composed of simple syrup, gum syrup, an intestinal solution, colored mucilage, color paste and the like. The method comprises the steps of pill core dewaxing, isolation layer wrapping, casing layer wrapping, pill selection and sugar coating layer wrapping. The coating material combination method can realize isolation and protection of active ingredients of the angelica volatile oil, prevent volatilization loss of the active ingredients, effectively protect the angelica volatile oil and improve the stability of the angelica volatile oil.

Description

Technical Field

[0001] The invention belongs to the technical field of application of angelica volatile oil, and particularly relates to a coating material and a coating method for a Chinese medicine drop pill containing angelica volatile oil. Background Art

[0002] Angelica volatile oil is the main active ingredient of Angelica sinensis. Its chemical composition is complex, mainly containing compounds such as phthalides, terpenes and alkanes. The specific content varies depending on the raw materials of the medicinal pieces, extraction process, etc. Angelica volatile oil has a high clinical application value and a wide range. Related drugs all use coating technology to prevent the volatilization of the active ingredients in the volatile oil.

[0003] The coating technologies in the prior art can be roughly divided into the following categories: Spray coating: The principle is to spray the coating liquid into mist droplets to cover the surface of the material (such as powder, granules, tablets), and quickly dry to form a coating layer. Spray coating has efficient and uniform coating capabilities.

[0004] Dip coating: involves dipping the material into the coating liquid, then removing it and allowing the excess liquid to drip off, followed by drying to form a coating. Suitable for some specific application scenarios.

[0005] Dry compression coating: Compression coating is implemented through a tablet press, which is suitable for all kinds of coatings, especially drug coatings (multi-layer tablets).

[0006] Electrostatic coating: Use electrostatic effect to adsorb charged coating materials on the surface of the material to form a uniform coating layer.

[0007] Laminate coating: Multiple layers of materials are sequentially applied to the material, and then bonded together by heating or pressing to form a multi-layer coating.

[0008] Compared with other volatiles, angelica volatile oil is more volatile and more unstable under light and heat, and is easily lost, which seriously affects the stability of angelica preparations. The above coating methods and their simple combinations cannot effectively retain the active ingredients in angelica volatile oil. Based on this, the production staff proposed a coating material and coating method for Chinese medicine drop pills containing angelica volatile oil. Summary of the invention

[0009] The purpose of the present invention is to provide a coating material and a coating method for Chinese medicine drop pills containing angelica volatile oil, so as to solve the problem that the simple coating process of angelica volatile oil easily causes the loss of effective ingredients.

[0010] In order to solve the above problems, the technical solution of the present invention is: A coating material for Chinese medicine drop pills containing angelica volatile oil, the material is composed of simple sugar syrup, gum syrup, enteric solution, color glue syrup, and color paste; Wherein: the monosaccharide syrup is composed of 5.9-6.1 kg of sucrose and 2.5-2.7 kg of purified water; The gum syrup is composed of 8.2-8.4 kg of sucrose, 0.21-0.23 kg of gelatin, and 3.5-3.7 kg of purified water; The enteric solution is composed of 3.3-3.5 kg of polyacrylic acid resin II, 37-39 kg of ethanol, 1.02-1.22 kg of diethyl phthalate, 740-760 ml of Tween-80, and 740-760 ml of castor oil; The color paste is composed of 4.12-4.32 kg of sucrose, 0.07-0.09 kg of gelatin, 0.01 kg of food coloring, and 1.7-1.9 kg of purified water; The color paste is composed of 11.0-11.8 kg of sucrose, 0.04 kg of food coloring, and 4.8-5.0 kg of purified water.

[0011] The coating method of the above-mentioned Chinese medicine dripping pill coating material containing angelica volatile oil is divided into the following steps: S1, dewaxing of pellet core; Weigh the qualified pill cores and pour them into the coating machine. Use a small piece of filter paper to absorb the liquid paraffin on the surface of the pill cores. The pill cores should be loose and non-sticky. S2, package isolation layer; First coat with simple syrup 1 layer, then coat with gum syrup 4 layers, and finally coat with simple syrup 2 layers; S2.1, coat with monosaccharide syrup once; Put the monosaccharide syrup into the coating machine and stir, disperse the balls, and evenly adhere the monosaccharide syrup to the surface of the balls. Add talcum powder and stir evenly, and blow dry with hot air for no less than 50 minutes. S2.2, encapsulation syrup layer 4 times; Repeat the following steps 4 times: put the gum syrup into the coating machine and stir to disperse the balls and make the gum syrup evenly adhere to the surface of the balls, add talcum powder and stir evenly, and blow dry with hot air for no less than 50 minutes; S2.3, coat with monosaccharide syrup twice; Repeat the following steps twice: put monosaccharide into the coating machine and stir to disperse the balls and make the monosaccharide syrup evenly adhere to the surface of the balls, add talcum powder and stir evenly, and blow dry with hot air for no less than 50 minutes; S3, enteric coating layer; Put the balls coated with the isolation layer into the coating machine, add part of the enteric solution, stir to disperse the balls, and evenly adhere the enteric solution to the surface of the balls. Blow dry with hot air for no less than 20 minutes; then spray the remaining enteric solution into the water chestnut-type coating pot at a speed that the balls in the coating machine do not stick. After the enteric solution is sprayed, blow cool air to bring the balls to room temperature and stop the machine; S4, pill selection; Use a sample sieve to screen out unqualified pills with a pore size greater than 5.0 mm and less than 3.0 mm, then use a pill selection machine to select the sticky pills, and add the selected qualified pills to the coating machine; S5, sugar coating layer; S5.1, sugar coating inner layer; Repeat the following steps twice: put the color slurry into the coating machine and stir to disperse the balls and make the color slurry evenly adhere to the surface of the balls, add talcum powder and stir evenly, open hot air to dry, the drying time is not less than 50 minutes, and coat the color slurry twice; S5.2, sugar coating outer layer; S5.2.1, pack the color paste twice; Repeat the following steps twice: put the color paste into the coating machine and stir to disperse the balls and make the color paste evenly adhere to the surface of the balls, add talcum powder and stir evenly, and blow dry with hot air for no less than 40 minutes; do not add talcum powder for the second time, blow dry with cool air for no less than 30 minutes; S5.2.2, pack the color paste 5 times; Repeat the following steps 5 times: Put the color paste into the coating machine and stir to disperse the balls and make the color paste evenly adhere to the surface of the balls. Blow dry with cool air for no less than 15 minutes.

[0012] The beneficial effects of the present invention are as follows: (1) In the drop pill coating material of the present invention, the principles of the various components and their content ratios are as follows: The ratio of sucrose and purified water used in simple syrup is based on the solubility of sucrose and its effect on the quality of the syrup.

[0013] In the preparation of gum syrup, the ratio principle of sucrose, gelatin and purified water mainly involves the stability and acceptability of gum syrup. Among them, sucrose is used as a sweetener, and its content directly affects the sweetness of gum syrup. The amount of addition is determined according to the sweetness requirements of the product, and the effect of sucrose on the stability of gum syrup is also considered; gelatin is used as a gelling agent, and its content determines the consistency and stability of gum syrup. The amount of addition is adjusted according to the required consistency and stability to ensure that the gum syrup maintains a stable form during storage and transportation; purified water is used as a solvent, and its role is to help dissolve sucrose and gelatin to form a uniform gum syrup. The amount of addition is determined according to the solubility of sucrose and gelatin and the required final volume to ensure that all ingredients can be fully dissolved, while avoiding the quality of gum syrup affected by too much or too little water.

[0014] In the formula of enteric solution, polyacrylic resin II is an anionic methacrylic acid copolymer, which is insoluble in gastric juice but soluble in intestinal juice. It is an ideal enteric coating material. By selecting polyacrylic resin II, the drug can be coated so that it is insoluble in gastric juice but soluble in intestinal juice, thereby ensuring the release of the drug in the intestine and improving the bioavailability and therapeutic effect of the drug; ethanol solution is used as a solvent; diethyl phthalate is used to improve the water resistance, elasticity, light resistance and hardness of the product; the role of Tween is to promote the dispersion and stability of the drug, and it also helps to form a stable complex of the drug, thereby improving the solubility of the drug in the aqueous phase, enhancing its bioavailability, and possibly enhancing the efficacy. It also has certain antioxidant and light shielding effects, which helps to protect the drug molecules from being affected by external environmental factors, thereby improving the chemical stability of the drug and extending its storage life; castor oil has a certain lubricating effect.

[0015] In the formula of color paste, sucrose, as a common sweetener and humectant, can increase the sweetness and viscosity of the product, while playing a role in moisturizing and stabilizing the product; it can also prevent water evaporation and maintain the wetness and uniformity of the product; gelatin, as a natural high molecular compound, has good film-forming and adhesive properties, and can be used as a binder to help pigments and other ingredients better adhere to the surface of objects to form a uniform coating; food coloring is used to color the color paste to give it a variety of bright colors. It is safe and non-toxic, meets food grade standards, can meet different color requirements, and increase the attractiveness and practicality of the product; purified water, as a solvent, plays a role in diluting and blending various ingredients to ensure the uniformity and stability of the color paste, and can reduce the impact of impurities on the performance of the color paste to ensure the quality and stability of the product.

[0016] Color paste achieves coloring effect through chemical reaction and physical mixing. Caramel color can be prepared by heating sucrose in the presence of acid or acidic ammonium salt. This process includes several stages: first, sucrose melts and begins to bubble, and then removes a water molecule to form isosucrose anhydride, which is the beginning reaction of caramelization. Next, isosucrose anhydride is further dehydrated to form caramel anhydride. Finally, caramel anhydride continues to be heated and dehydrated to form high molecular weight caramel. This process produces dark brown caramel color; food coloring is directly used for coloring. They can be natural pigments such as red yeast rice pigment, shellac pigment, carminic acid, etc., or synthetic pigments. These pigments play a direct coloring role in the color paste, and the desired color effect can be achieved by adjusting their proportion and type; purified water is mainly used to dilute and blend various ingredients in the color paste production process to ensure the uniformity and stability of the color paste. It can also help dissolve solid components and prevent the color paste from precipitating or stratifying during storage and use; through the above process, the color paste can effectively convert sucrose into caramel color, and use food coloring for coloring, and finally obtain a stable and uniform color paste product.

[0017] (2) In the method of the present invention, the light liquid paraffin is fully removed during the dewaxing of the pill core, so that the monosaccharide syrup and talcum powder can be evenly coated on the pill core to prevent it from falling off. If there is residual paraffin on the surface of the pill core, it will be difficult for the coating material to adhere evenly, which will lead to unstable quality of the coating layer and affect the release and absorption of the drug.

[0018] When coating the isolation layer, the coating is divided into three layers, and the multiple layers of gum syrup are sandwiched between the monosaccharide syrups. The coating of this isolation layer distribution is based on the following considerations: the gum syrup has high viscosity. If it is used as the innermost layer in direct contact with the pill core, it is easy to cause adhesion between the pill cores. Therefore, the innermost layer is first coated with a layer of monosaccharide syrup to lubricate and disperse the pill cores, making it easier to disperse the pill cores during the coating process to avoid adhesion; and the 4 layers of gum syrup in the middle play a very important role as an isolation barrier. The arrangement of the 4 layers of gum syrup can form a tight and tough combined film layer, which effectively prevents moisture, air and other Other impurities penetrate into the interior of the medicine, which can further protect the volatile oil of Angelica sinensis from being damaged by the external environment, and the viscosity of the gum syrup can also help it adhere to the pill core better to form a solid coating layer; but due to the high viscosity of the gum syrup, the surface of the pills coated with the gum syrup may become rough, which will bring difficulties to the subsequent coating process, so the outermost layer of the isolation layer is coated with a monosaccharide syrup layer twice. At this time, the monosaccharide syrup can make the surface of the pills round and smooth, which lays a good foundation for easier wrapping of the enteric coating layer in the subsequent process. At the same time, these two layers of monosaccharide syrup can also enhance the firmness and stability of the entire coating layer.

[0019] The enteric coating layer acts as a protective film covering the surface of the pills to prevent the drug from being released prematurely in the gastrointestinal tract or being affected by gastric acid, allowing the drug to safely pass through the stomach and reach the small intestine to dissolve, thereby promoting the absorption of the medicinal effects of angelica volatile oil. At the same time, the enteric coating layer can also control the release rate of the drug, allowing the drug to be released slowly within a specific time, thereby improving the efficacy and safety of the drug.

[0020] The pill selection process removes unqualified pills and sticky pills to ensure the consistency of the thickness and composition of the coating layer. Pills with uniform size and smaller coating thickness error can better control the drug release rate to maintain a uniform level; if the pills are inconsistent in size or there is adhesion, the thickness and composition of the coating layer will be affected, which will lead to uneven release rate of the angelica volatile oil encapsulated in the coating layer, and the efficacy will not be able to be maintained at a stable level.

[0021] In the final sugar coating process, the inner layer is coated with a highly viscous color paste, which can better wrap the enteric coating, prevent adhesion between sugar coating layers, and enhance the firmness of subsequent sugar coating layers; however, the color paste is highly viscous, and the surface of the balls after two layers of color paste is not smooth, so further sugar coating outer layer process is required to supplement it. Two layers of color paste are used to make the surface of the balls round and smooth, and the following five layers of color paste can make the color of the balls uniform, increasing the aesthetics of the medicine. The coating of the entire sugar coating layer can also further increase the moisture-proof and light-proof properties of the balls and improve the stability of the medicine.

[0022] (3) The above coating material combination method can achieve the isolation and protection of the effective components of Angelica sinensis volatile oil, prevent the volatilization and loss of the effective components, effectively protect the Angelica sinensis volatile oil and improve its stability. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 The present invention is a process flow chart of a coating method of a Chinese medicine drop pill containing angelica volatile oil; Figure 2 The structural diagram of a coating product of Chinese medicine drop pills containing angelica volatile oil; Figure 3 These are external pictures of randomly selected samples of Product 1 and Product 2 after being stored for 6 months. DETAILED DESCRIPTION

[0024] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0025] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the invention as claimed but is merely representative of selected embodiments of the present invention.

[0026] Example 1 A coating material for Chinese medicine drop pills containing angelica volatile oil, the material is composed of the following components: monosaccharide syrup, gum syrup, enteric solution, color glue syrup, color paste. Calculated based on 2.16 million pills (total pill core weight 43.2kg), of which: The simple syrup is composed of 5 kg of sucrose and 2.6 kg of purified water; after compounding, it is about 6600 ml.

[0027] The gum syrup is composed of 8.3 kg of sucrose, 0.22 kg of gelatin, and 3.6 kg of purified water; after compounding, it is about 8800 ml; The enteric solution is composed of 3.4 kg of polyacrylic acid resin II, 38 kg of ethanol, 1.02-1.22 kg of diethyl phthalate, 750 ml of Tween-80, and 750 ml of castor oil; after compounding, it is about 51000 ml; The color paste is composed of 4.22kg of sucrose, 0.08kg of gelatin, 0.01kg of food coloring, and 1.8kg of purified water; after compounding, it is about 4400ml; The color paste consists of 11.4kg of sucrose, 0.04kg of food coloring, and 4.9kg of purified water; after compounding, it is about 11500ml; like Figure 1 As shown, a coating method for Chinese medicine drop pills containing angelica volatile oil is divided into the following steps: S1, dewaxing of pellet core; Weigh the qualified pill cores and pour them evenly into two water chestnut-type coating machines. Start the coating machines and put in a small piece of filter paper to allow the liquid paraffin on the surface of the pill core to be adsorbed on the filter paper. After the filter paper is full, take it out and put in new filter paper. Repeatedly replace the filter paper several times until the liquid paraffin on the surface of the pill core is cleanly adsorbed and the pill core is loose and non-sticky.

[0028] S2, package isolation layer; First, one layer of monosaccharide syrup is applied, then four layers of gum syrup are applied, and finally two layers of monosaccharide syrup are applied. The monosaccharide syrup sandwiches the multiple layers of gum syrup to form the innermost layer as an isolation layer coating, which is in direct contact with the angelica volatile oil. On the one hand, it ensures the stability of the properties of the angelica volatile oil, and on the other hand, it is isolated from the outside to prevent volatilization. The ratio of sucrose and purified water is based on the solubility of sucrose and its effect on the quality of the syrup.

[0029] S2.1, coat with monosaccharide syrup once; Measure 2200 ml of monosaccharide syrup, add it into a water chestnut-type coating machine and stir to disperse the balls and allow the monosaccharide syrup to adhere evenly to the surface of the balls. Add about 10.6 kg of talcum powder and stir evenly. Turn on the hot air to dry, and the drying time should be no less than 50 minutes.

[0030] S2.2, encapsulation syrup layer 4 times; Measure 2200 ml of gum syrup each time, add it into the water chestnut-type coating machine and stir to disperse the balls. The gum syrup is evenly adhered to the surface of the balls. Add talcum powder and stir evenly. Turn on the hot air to dry. The drying time should not be less than 50 minutes.

[0031] The above operation was repeated 4 times, and the amount of talcum powder added for the 4 coatings was 9.0 kg, 8.6 kg, 7.0 kg and 6.0 kg respectively.

[0032] S2.3, coat with monosaccharide syrup twice; Take 2200ml of monosaccharide syrup each time, add it to the water chestnut coating machine and stir it to disperse the balls. The monosaccharide syrup is evenly adhered to the surface of the balls. Add talcum powder and stir evenly. Blow dry with hot air for no less than 50 minutes. Repeat the above operation twice, and the amount of talcum powder added in the two coatings is 5.0kg and 5.0kg respectively.

[0033] S3, enteric coating layer; Put the balls with the isolation layer into the water chestnut coating machine, add 1200ml of enteric solution, stir to disperse the balls, and evenly adhere the enteric solution to the surface of the balls. Blow dry with hot air for no less than 20 minutes. Then spray the remaining 49800ml of enteric solution into the water chestnut coating pot. The spraying speed is appropriate to prevent the balls from sticking in the coating machine. After the enteric solution is sprayed, blow cool air to bring the balls to room temperature and stop the machine.

[0034] S4, pill selection; Use a sample sieve with a pore size of 3.0 mm to screen out unqualified small pills, and then use a sample sieve with a pore size of 5.0 mm to screen out unqualified large pills. Then use a pill selecting machine to select the sticky pills, and then add the selected qualified pills into the water chestnut coating machine.

[0035] S5, sugar coating layer; S5.1, sugar coating inner layer; Coating the color paste twice: Take 2200ml of the color paste each time, add it into the water chestnut-type coating machine and stir it to disperse the balls. The color paste is evenly adhered to the surface of the balls. Add talcum powder and stir evenly. Blow dry with hot air for no less than 50 minutes. Repeat the above operation twice, and the amount of talcum powder added for the two coatings is 4.00kg and 4.00kg respectively.

[0036] S5.2, sugar coating outer layer; S5.2.1, pack the color paste twice; Measure 2200ml of color paste each time, add it into the water chestnut coating machine and stir to disperse the balls and make the color paste evenly adhere to the surface of the balls. Repeat the operation twice. For the first time, add about 3.3kg of talcum powder and stir evenly. Blow dry with hot air for no less than 40 minutes. Do not add talcum powder for the second time, blow dry with cool air for no less than 30 minutes.

[0037] S5.2.2, pack the color paste 5 times; Add 1800ml, 1600ml, 1400ml, 1200ml and 1100ml of color paste into the water chestnut coating machine respectively. After adding the color paste each time, turn on the cool air to dry it. The drying time should not be less than 15 minutes.

[0038] The product produced above is numbered as product 1.

[0039] Example 2 The difference from Example 1 is that: A coating material for Chinese medicinal drop pills containing angelica volatile oil, the material is composed of the following components: monosaccharide syrup, gum syrup, enteric solution, color glue syrup, and color paste.

[0040] The simple syrup is composed of 5.9 kg of sucrose and 2.7 kg of purified water; after compounding, it is about 6600 ml.

[0041] The gum syrup is composed of 8.2 kg of sucrose, 0.21 kg of gelatin, and 3.7 kg of purified water; after compounding, it is about 8800 ml; The enteric solution is composed of 3.5 kg of polyacrylic acid resin II, 37 kg of ethanol, 1.22 kg of diethyl phthalate, 760 ml of Tween-80, and 760 ml of castor oil; after compounding, it is about 51000 ml; The color paste is composed of 4.12kg of sucrose, 0.09kg of gelatin, 0.01kg of food coloring, and 1.9kg of purified water; after compounding, it is about 4400ml; The color paste consists of 11.0kg of sucrose, 0.04kg of food coloring, and 5.0kg of purified water; after compounding, it is about 11500ml.

[0042] Example 3 The difference from Example 1 is that: A coating material for Chinese medicinal drop pills containing angelica volatile oil, the material is composed of the following components: monosaccharide syrup, gum syrup, enteric solution, color glue syrup, and color paste.

[0043] The simple syrup is composed of 6.1 kg of sucrose and 2.5 kg of purified water; after compounding, it is about 6600 ml; The gum syrup is composed of 8.4 kg of sucrose, 0.23 kg of gelatin, and 3.5 kg of purified water; after compounding, it is about 8800 ml; The enteric solution is composed of 3.3 kg of polyacrylic acid resin II, 39 kg of ethanol, 1.02 kg of diethyl phthalate, 740 ml of Tween-80, and 740 ml of castor oil; after compounding, it is about 51000 ml; The color paste is composed of 4.32kg of sucrose, 0.07kg of gelatin, 0.01kg of food coloring, and 1.7kg of purified water; after compounding, it is about 4400ml; The color paste consists of 11.8kg of sucrose, 0.04kg of food coloring, and 5.0kg of purified water; after compounding, it is about 11500ml.

[0044] It should be noted that in the above-mentioned embodiments, the coating materials are weighed when they are taken, and are mostly weighed by mass. However, after being compounded into coating agent components and entering the coating production workshop, the materials added in each process link are measured by volume, and the measurement in the production link has a measurement error allowed by the workshop.

[0045] Comparative Example 1 The difference from Example 1 is that: This comparative example adopts a traditional coating material formula, which mainly includes: shellac, castor oil, acrylic resin No. 2, diethyl phthalate, castor oil, Tween-80, talcum powder, pigment, etc., which are dissolved in an appropriate amount of ethanol and combined for coating; The above coating materials are coated by spray coating method, and the original process adopts the process method of coating the isolation layer first, the powder coating layer, and then the sugar coating layer. The product number produced above is product 2.

[0046] This traditional method can also meet the coating requirements, but compared with the coating method of the present invention, the main problem is that it is impossible to effectively control the volatilization and migration of the angelica oil in the pill core after coating, which will lead to serious changes in the product appearance and the loss of the active ingredients contained in the pill core.

[0047] Efficacy comparison: 1. Appearance comparison.

[0048] Randomly sample product 1 and product 2 and continuously observe the changes in their appearance during the validity period. After 6 months, the appearance of product 1 is Figure 3 As shown in (a), the appearance of product 2 is as follows Figure 3 As shown in (b), it can be found that the surface of product 2 is obviously blackened, while product 1 has no obvious change, and the blackening of the surface of product 2 becomes more obvious as time goes by. The reason is that the angelica oil in the pill core migrates.

[0049] 2. Comparison of the contents of main ingredients.

[0050] Product 1 and Product 2 were randomly sampled and parallel experiments were conducted on the samples just out of the factory in the same laboratory and by the same experimenter to detect the active ingredient (ligustilide). The test results are shown in Table 1.

[0051] The above samples were stored at a constant temperature in a cool place for 36 months. After the storage period, parallel experiments were carried out on the samples in the same laboratory and by the same experimenter to continue detecting the effective ingredients (ligustilide, labeled according to the amount contained in the pill core in this embodiment). The test results are shown in Table 1.

[0052] Product 1 Product 2 Factory active ingredient content 42.3mg / g 42.6 Active ingredient content after 6 months of storage 42.2mg / g 42.0 Active ingredient content after 12 months of storage 42.2mg / g 41.2 Active ingredient content after 24 months of storage 42.1mg / g 40.6 Active ingredient content after 36 months of storage 42.0mg / g 40.1 Table 1 shows: Although the main component content of product 1 decreased during the 36-month storage period, it only decreased by nearly 0.7%; while the main component content of product 2 produced by the original coating material and coating method continued to decrease during the 36-month storage period, and the main component content decreased by as much as 5.9%. It can be seen that the products produced by the coating material and coating method of the present invention have higher stability, can achieve isolation and protection of the effective components of angelica volatile oil, and prevent the volatilization and loss of the effective components.

Claims

1. A coating material for Chinese medicine drop pills containing angelica volatile oil, characterized in that: The material is composed of simple sugar syrup, gum syrup, enteric solution, color glue syrup, and color paste; Wherein: the monosaccharide syrup is composed of 5.9-6.1 kg of sucrose and 2.5-2.7 kg of purified water; The gum syrup is composed of 8.2-8.4 kg of sucrose, 0.21-0.23 kg of gelatin, and 3.5-3.7 kg of purified water; The enteric solution is composed of 3.3-3.5 kg of polyacrylic acid resin II, 37-39 kg of ethanol, 1.02-1.22 kg of diethyl phthalate, 740-760 ml of Tween-80, and 740-760 ml of castor oil; The color paste is composed of 4.12-4.32 kg of sucrose, 0.07-0.09 kg of gelatin, 0.01 kg of food coloring, and 1.7-1.9 kg of purified water; The color paste is composed of 11.0-11.8 kg of sucrose, 0.04 kg of food coloring, and 4.8-5.0 kg of purified water.

2. A coating method for Chinese medicine pills containing angelica volatile oil, characterized in that: The method consists of the following steps: S1, dewaxing of pellet core; Weigh the qualified pill cores and pour them into the coating machine. Use a small piece of filter paper to absorb the liquid paraffin on the surface of the pill cores. The pill cores should be loose and non-sticky. S2, package isolation layer; First coat with simple syrup 1 layer, then coat with gum syrup 4 layers, and finally coat with simple syrup 2 layers; S2.1, coat with monosaccharide syrup once; Put the monosaccharide syrup into the coating machine and stir, disperse the balls, and evenly adhere the monosaccharide syrup to the surface of the balls. Add talcum powder and stir evenly, and blow dry with hot air for no less than 50 minutes. S2.2, encapsulation syrup layer 4 times; Repeat the following steps 4 times: put the gum syrup into the coating machine and stir to disperse the balls and make the gum syrup evenly adhere to the surface of the balls, add talcum powder and stir evenly, and blow dry with hot air for no less than 50 minutes; S2.3, coat with monosaccharide syrup twice; Repeat the following steps twice: put monosaccharide into the coating machine and stir to disperse the balls and make the monosaccharide syrup evenly adhere to the surface of the balls, add talcum powder and stir evenly, and blow dry with hot air for no less than 50 minutes; S3, enteric coating layer; Put the balls coated with the isolation layer into the coating machine, add part of the enteric solution, stir to disperse the balls, and make the enteric solution adhere evenly to the surface of the balls, and blow dry with hot air for no less than 20 minutes; Then spray the remaining enteric solution into the water chestnut-type coating pot at a speed that the balls in the coating machine do not stick together. After the enteric solution is sprayed, blow cool air to bring the balls to room temperature and stop the machine. S4, pill selection; Use a sample sieve to screen out unqualified pills with a pore size greater than 5.0 mm and less than 3.0 mm, then use a pill selection machine to select the sticky pills, and add the selected qualified pills to the coating machine; S5, sugar coating layer; S5.1, sugar coating inner layer; Repeat the following steps twice: put the color slurry into the coating machine and stir to disperse the balls and make the color slurry evenly adhere to the surface of the balls, add talcum powder and stir evenly, open hot air to dry, the drying time is not less than 50 minutes, and coat the color slurry twice; S5.2, sugar coating outer layer; S5.2.1, pack the color paste twice; Repeat the following steps twice: put the color paste into the coating machine and stir to disperse the balls and make the color paste evenly adhere to the surface of the balls, add talcum powder and stir evenly, and blow dry with hot air for no less than 40 minutes; do not add talcum powder for the second time, blow dry with cool air for no less than 30 minutes; S5.2.2, pack color paste 5 times; Repeat the following steps 5 times: Put the color paste into the coating machine and stir to disperse the balls and make the color paste evenly adhere to the surface of the balls. Blow dry with cool air for no less than 15 minutes.

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